Cell tumor cells or tumor cells cells acquire antigens from tumors antigen of tumor. Medical search. Frequent questions

However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)
Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
Regardless of the therapeutic approach, the heterogeneity of pancreatic cancer cells and the complexity of its tumor microenvironment contribute to the emergence of drug resistance. (frontiersin.org)
Liquid biopsy is a useful tool for accurately monitoring dynamic changes in tumor immune heterogeneity and the tumor microenvironment. (spandidos-publications.com)
Tumor cells are influenced by both genetic factors and environmental elements in the microenvironment, resulting in a complex regulation process ( 1 ). (spandidos-publications.com)
Various subclonal tumor cells have the ability to modify the tumor microenvironment in order to obtain adaptations. (spandidos-publications.com)
Furthermore, tumor heterogeneity has a significant impact on both the immune microenvironment and the infiltration of various immune cells within tumors, such as cytotoxic T lymphocytes (CTLs) ( 5 ), myeloid antigen-presenting cells ( 6 ) and cancer-associated fibroblasts (CAFs) ( 7 ). (spandidos-publications.com)
It has been discovered that the genetic structure of tumor cells and the components of the immune microenvironment interact with each other. (spandidos-publications.com)
This interaction results in a more complex alteration of both the heterogeneity of tumor cells and the heterogeneity of the tumor microenvironment. (spandidos-publications.com)
On the biological side, I am interested in tumor heterogeneity and characteristics, such as tumor microenvironment, gene expression, mutational landscape, immune infiltration. (unil.ch)
The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)

Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
In certain cases, tumor-infiltrating lymphocytes could also be assessed for such responses. (bmj.com)
As shown by multiplex tissue immunofluorescence and intravital microscopy, combined immunotherapy treatments enhance T cell infiltration and the intratumoral performance of T lymphocytes. (unav.edu)
Indeed, an increase in the recruitment of cytotoxic CD8 + T-lymphocytes into the tumor is mediated by chemokines such as C-C motif chemokine ligand 5, C-X-C motif chemokine ligand 9 (CXCL9) and CXCL10 and is correlated to lower metastasis risk and better outcome for patients [ 1 - 3 ] [Figure 1] . (oaepublish.com)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)

Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
It is postulated that these cells may acquire neuroendocrine features during malignant transformation. (medscape.com)
Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)
Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
Efficacy was dependent on the number of CD8+ T cells able to recognize tumor antigens that infiltrated the malignant tissue. (unav.edu)
Immunodeficiencies are genetic diseases known to predispose an individual to cancer owing to defective immunity towards malignant cells. (biomedcentral.com)
These therapeutic methods, including but not limited to oncolytic virus therapies, T-cell therapies and cancer vaccines, are based on the body's ability to recognize mutated antigen peptides presented on the cell surface by MCH-receptors (also known as HLA-receptors in humans) and the disposal of the malignant cells by cytotoxic T-cells. (helsinki.fi)

Immunotherapy for cancer focuses on boosting the power of the body's own immune system to fight tumors. (issels.com)
Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience. (nwbio.com)
Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: a phase I study. (nwbio.com)
Good described a method for deep single-cell phenotyping, measuring 30-plus features for every cell, across division states during critical differentiation periods in the context of cell expansion for immunotherapy. (stanford.edu)
Nevertheless, ex vivo activation with cytokines can restore cytolytic activity of NK cells against GB, indicating that NK cells have potential for adoptive immunotherapy of GB if potent cytotoxicity can be maintained in vivo . (frontiersin.org)
Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)
However, the study of tumor immune heterogeneity holds great potential for clinical immunotherapy. (spandidos-publications.com)
Immunotherapy protocols are designed to annihilate immune escape in cancer cells and restore elimination of cancer cells. (oaepublish.com)
The more I learned about cancer, the better I understood that its therapy should rely on a personalized and exhaustive molecular and cellular characterization of tumors and that immunotherapy represents the most promising clinical approach. (unil.ch)
I focus my work on the identification of clinically relevant cancer specific Human Leukocyte Antigen (HLA) ligands that will guide the development of personalized cancer immunotherapy. (unil.ch)
Immunotherapy can fail in patients with cancer when certain cancer cells can hide from the immune system. (lu.se)
However, cDC1 can be compromised in cancer patients and some cancer cells lack these antigen-presenting proteins on their surface, impacting immunotherapy response. (lu.se)

Antigen presentation by the professional antigen-presenting cells (APCs) are normally recognized by immune cells via a surface T-cell receptor (TCR), leading to the induction of naive CD8 + T-cell clonal expansion and differentiation and finally resulting in the cell death of APCs. (oaepublish.com)

Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
The new incoming challenge is now therefore to overcome these resistance and new recent data presented epigenetic modifications as promising targets to restore anti-tumor immunity. (oaepublish.com)
Alexandra Gabriela Barros Ferreira defends her Ph.D. thesis "Restoring antitumor immunity with dendritic cell reprogramming strategies" on Friday, 17 November, 2023. (lu.se)
My Ph.D. studies have focused on restoring anti-tumor immunity with dendritic cell reprogramming strategies. (lu.se)

However, systematic analysis of T cell immune responses to MAGE-A3 antigen and corresponding antigen-specific TCR is still lacking. (thno.org)

Scientists at the Swiss Institute for Experimental Cancer Research have developed a modification that allows dendritic cells to acquire antigens from a patient's tumor. (issels.com)
Engineered TCR-modified T cells (TCR-T cells) are reprogrammed to express a TCR that can recognize specific antigens only present on tumor cells, thereby enabling a precise and potent immune response to attack a patient's tumor. (pressetext.com)

Although immune checkpoint blockade (ICB) reinvigorates anti-tumor immune responses by disrupting co-inhibitory T-cell signaling, relapse frequently occurs after ICB treatment and acquired resistance often emergence after initial response [ 4 ]. (thno.org)
My thesis focused on studying the anti-tumor immune responses induced by concomitant chemoradiation in non-small cell lung cancer, head and neck cancer patients and in mouse tumor models. (unil.ch)

Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. (cusabio.cn)

We identified the HLA-A2 restricted T cell epitopes from MAGE-A3 that could effectively induce the activation and cytotoxicity of CD8+ T cells using artificial APC in vitro . (thno.org)
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)
By using direct reprogramming strategies, I could induce the expression of tumor antigens on the surface of cancer cells, making them visible to the immune system again. (lu.se)
We focused particularly on harnessing reprogramming, or direct cellular reprogramming, to induce antigen presentation in cancer cells. (lu.se)
Direct reprogramming strategies with cDC1-specific factors can induce antigen-presentation in cancer cells, making cancer cells visible to the immune system and easier to fight. (lu.se)

In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
The innate immune system is mainly composed of myeloid lineage cells, such as macrophages, neutrophils, and mast cells [ 2 ]. (hindawi.com)
Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
The induction of CD11b + Gr-1 + myeloid-derived suppressor cells (MDSCs) is an important immune-evading mechanism used by tumors. (ashpublications.org)
In a second project, I studied the impact of Tie-2/angiopoietin-2 axis on myeloid-derived suppressor cells' immunosuppressive properties and on patient outcome. (unil.ch)

Scientists in Switzerland have now developed a method of modifying dendritic cell vaccines that makes them easier to personalize. (issels.com)
Dendritic cell vaccines are normally created by force-feeding dendritic cells with tumor antigens. (issels.com)
The process simplifies the immune response by eliminating the need for more complex interactions within the dendritic cell itself. (issels.com)
The dendritic cell vaccine is one of the most potent weapons in our cancer-fighting arsenal, succeeding in many late-stage patients for whom other treatments had failed. (issels.com)
Dendritic cell vaccines are an effective method of increasing their numbers. (issels.com)
Dendritic cell vaccines are only one of the innovative treatments we use for patients with all forms of cancer. (issels.com)
Maturation and trafficking of monocyte-derived dendritic cells in monkeys: implications for dendritic cell-based vaccines. (nwbio.com)

Single-cell sequencing is a high-throughput technique that enables detection of genomic, transcriptomic, and epigenomic information at the individual cell level, offering significant advantages in detecting cellular heterogeneity, precise cell classification, and identifying rare subpopulations. (frontiersin.org)
The heterogeneity of glioblastoma can suppress immune cell function and lead to immune evasion, which presents a challenge in developing effective molecular therapies for tumor cells. (spandidos-publications.com)
Glioblastoma (GBM) is characterized by significant genetic heterogeneity among tumor cells. (spandidos-publications.com)
This heterogeneity is referred to as 'polymorphism', as tumor cells rapidly undergo mitosis, resulting in the formation of numerous subclones and uncertainty regarding the state of the genome. (spandidos-publications.com)
This heterogeneity can vary greatly between different types of immune cells, leading to further complexity in understanding the immune response to tumors. (spandidos-publications.com)
Consequently, the heterogeneity of tumor cells is constantly evolving. (spandidos-publications.com)
Thus, tumor heterogeneity has an important role in tumor development. (spandidos-publications.com)
These studies reveal a wide range of genetic tumor heterogeneity in both spatial and temporal dimensions, encompassing diverse single-nucleotide mutations, insertions, deletions and copy number variations ( 9 , 10 ). (spandidos-publications.com)
Aiming to interrogate cell heterogeneity, I also performed some studies in a platform for single cell genomics and epigenomics. (unil.ch)

In doing this, scientists also have the opportunity to intervene while cells are developing in order to change the progression of their development and ultimately the disease. (stanford.edu)
Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)
Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. (cusabio.cn)

This collaboration with Medigene expands our cell therapy portfolio and TCR discovery capabilities, and further strengthens our ability to be a leader in the rapidly emerging field of engineered cell therapies," said Ugur Sahin, M.D., Chief Executive Officer and Co-Founder of BioNTech . (pressetext.com)
Overall, our data refine tumor-induced MDSC functions by uncovering mechanistically distinct MDSC subpopulations, potentially relevant for MDSC-targeted therapies. (ashpublications.org)
It unlocks novel dimensions by uncovering elusive cell populations and tumor heterogeneities for early detection, unraveling mechanisms of treatment resistance, tailoring therapies to individuals, and illuminating metastasis and cachexia pathways, thereby opening fresh avenues for preventive strategies. (frontiersin.org)
For this purpose, I use different omics layers to identify antigens which can be translated into potential cancer vaccines or cell therapies. (unil.ch)
Even though the idea of an immune system actively searching for and disposing of potential mutated tumor cells is over a century old, only recent developments in various fields such as mass spectrometry, immuno-checkpoint blockade strategies and in silico modelling have enabled the realization of the full potential of recruiting immune system to fight cancer and the possibilities of personalized therapies. (helsinki.fi)

Adoptive cell therapy using engineered T-cell receptors (TCRs) targeting cancer-testis antigens, such as Melanoma-associated antigen 3 (MAGE-A3), is a potential approach for the treatment of NSCLC. (thno.org)
Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)
Background Anti-programmed cell death protein 1 (PD-1) antibodies are now routinely administered for metastatic melanoma and for increasing numbers of other cancers, but still only a fraction of patients respond. (bmj.com)
We previously showed that the presence of NY-ESO-1-reactive and/or Melan-A-reactive T cells in the blood correlated with prolonged overall survival (OS) of patients with melanoma with a heterogeneous treatment background. (bmj.com)
Here, we investigated whether such reactive T cells can also be informative for clinical outcomes in metastatic melanoma under PD-1 immune-checkpoint blockade (ICB). (bmj.com)
Methods Peripheral blood T cell stimulation by NY-ESO-1 and Melan-A overlapping peptide libraries was assessed before and during ICB in two independent cohorts of a total of 111 patients with stage IV melanoma. (bmj.com)
An evaluation of melanoma tissue from selected cases suggested a correlation between tumor-resident NY-ESO-1- and Melan-A-reactive T cells and disease control, supporting the notion of a therapy-associated sequestration of cells from the periphery to the tumor predominantly in those patients benefitting from ICB. (bmj.com)
The era of immune checkpoint blockers (ICB), which started in 2011 with the approval of an antibody targeting cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells (namely, ipilimumab) for the treatment of metastatic melanoma ( 1 ), has brought a new paradigm to cancer therapy whereby the immune system is being harnessed to cure the cancer. (aacrjournals.org)

Dendritic cells are part of the immune system, serving as advance sentries that recognize the presence of foreign antigens. (issels.com)

Antigen-laden exosomes and other extracellular vesicles are released by tumors in sizable quantities. (issels.com)
These adaptations include inducing angiogenesis to acquire nutrient supply, interfering with immune stimulation/inhibition checkpoint pathways to promote immune evasion and remodeling the extracellular matrix to promote metastasis ( 3 ). (spandidos-publications.com)
In order to overcome these limitations, this study explored the possibility to use cancer cell derived extracellular vesicles (EVs) as drug delivery system for oncolytic adenovirus. (helsinki.fi)

Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. (nwbio.com)
Mainz/Martinsried/Munich, Germany, 21 February 2022 - BioNTech SE (Nasdaq: BNTX, "BioNTech") and Medigene AG (FSE: MDG1, Prime Standard, "Medigene"), a clinical-stage immuno-oncology company focusing on the development of T cell immunotherapies, today announced that they have entered a multi-target research collaboration to develop T cell receptor (TCR) based immunotherapies against cancer. (pressetext.com)
Emerging single-cell sequencing technologies will undoubtedly enhance our understanding of the complex biology of pancreatic cancer and pave the way for new directions in its clinical diagnosis and treatment. (frontiersin.org)
Further growth of cancer cells selected during the Equilibrium phase may then lead to the acquisition of aggressive phenotypes and resistance to immune system elimination inducing clinical lesions. (oaepublish.com)
The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
The distinction between acquired and inherited disease may present a clinical challenge, but more than 80% of cases are acquired. (medscape.com)
Clinical and laboratory observations suggest that acquired aplastic anemia is an autoimmune disease. (medscape.com)

Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells. (cusabio.cn)

These observations stimulated an intensive search for the mechanisms regulating tumor angiogenesis. (hindawi.com)
It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)
So, immune escape has now been included as one of the new hallmarks of cancer development described in the revised version of Hanahan and Weinberg [ 5 ] in 2011, together with resistance to cell death, replicative immortality or induced angiogenesis, for example. (oaepublish.com)

The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)

More recently, his group invented tools for cleavage-free large gene insertion via mining microbial recombination protein, and developed single-cell tracking approach for studying cancer biology and cancer immunology. (stanford.edu)
He is looking at gene signatures, different immune cell types and how they change. (stanford.edu)

13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)

BioNTech will acquire Medigene's next generation preclinical TCR program, which combines TCR-4 of Medigene's MDG10XX program targeting PRAME with Medigene's proprietary PD1-41BB switch receptor technology. (pressetext.com)
Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
Since then, several antibodies targeting another coinhibitory receptor, the programmed cell death 1 (PDCD1, best known as PD-1) or its main ligand CD274 (best known as PD-L1), have been approved for the treatment of multiple cancers ( 2 ). (aacrjournals.org)
Another challenge is the cell entry of oncolytic adenovirus, which is mainly mediated by the Coxsackie-Adenovirus receptor and this receptor is downregulated in various cancer cells. (helsinki.fi)

Digital pathology analysis was performed to quantify NY-ESO-1 and Melan-A expression by tumors. (bmj.com)
Additionally, induced co -expression of luciferase, EGFP, and the melanosomal antigen gp100 facilitates studies on the underlying immunological mechanisms. (unav.edu)
Indeed, both DNA methylation and post-translational histone modifications have been described to regulate immune checkpoint inhibitor expression, tumor-associated antigen presentation or cancer cell editing by the immune system and therefore establishing epigenetic drugs as a potential complement to immunotherapies to improve their efficiency. (oaepublish.com)
Flow cytometric analysis provided essential information of the cell line HLA-1 expression. (helsinki.fi)
Additional information of PD-L1 expression can be used to evaluate cell line's immune-evasion abilities. (helsinki.fi)
We aimed to determine the significance of detecting expression of some antigens that might be pivotal to the process, namely CD44 and CD117, in patients with active pemphigus vulgaris. (who.int)

NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)

Moreover, single-cell sequencing provides unique insights into the mechanisms of pancreatic cancer metastasis and cachexia, paving the way for developing novel preventive strategies. (frontiersin.org)
However, rather than actively modifying the environment, multiple mechanisms guide the evolution of tumor cells through the selection of subclones with the most adaptive phenotype by environmental factors ( 1 ). (spandidos-publications.com)

In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)

Combining tumor-specific adoptive T cell therapy to the aCTLA-4/aPD1/rIL2 or aCTLA-4/aPD1/aCD137 reg-imens enhances efficacy in a synergistic manner. (unav.edu)

Statistical and machine-learning based analyses demonstrated that the MAGE-A3-Mp4 epitope-specific CD8+ T cell clones were mostly in effector and proliferating state. (thno.org)
Interestingly, both MO-MDSCs and PMN-MDSCs suppressed antigen-specific T-cell responses, albeit using distinct effector molecules and signaling pathways. (ashpublications.org)
During the Elimination phase, some newly transformed cells can be quickly eliminated by immune effector cells, such as natural killers (NKs), but this phase can also favor the development of heterogeneous tumor cancer cells resulting in the selection of new variants resistant to immune edition. (oaepublish.com)

Analyzing small-scale tissue and cell samples can help us discover unique immunogenic cancer antigens. (unil.ch)
In silico methods were successfully used to characterize previously identified HLA-restricted peptides and one previously identified immunogenic T-cell epitope. (helsinki.fi)

T cell therapy has become a disruptive medical innovation in the treatment of patients with cancer. (pressetext.com)
Single-cell sequencing technology transforms the landscape of pancreatic cancer diagnosis and therapy. (frontiersin.org)

Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
Vasculogenesis is the coalescence of new blood vessels from individual endothelial cells or progenitor cells. (hindawi.com)
Plays a role in neutrophil adhesion to cytokine-activated endothelial cells. (cusabio.cn)
positively regulates cell migration, cell adhesion to endothelial cells and cell invasion. (cusabio.cn)

2. Interferon γ cytokine secretion was determined by ELISPOT to assess PBMC response against known antigens in a preliminary experiment to approximate usable range for the following antigen specific PBMC assays. (helsinki.fi)

It's in these transition points that the proteins are undergoing many changes, and we can use algorithms, essentially reducing the cell development stages to mathematical equations, to determine recurrence. (stanford.edu)

Rapid clearance and reduced cell entry thus lead to decreased amount of oncolytic adenovirus in target cells and decreased efficacy. (helsinki.fi)

The EVIR has been optimized to enhance dendritic cells and their ability to selectively uptake cancer cell-derived EVs. (issels.com)
Traditional cancer treatments often have side effects because they attack healthy cells along with tumor cells. (issels.com)
Dendritic cells can distinguish normal dying cells from cancer cells so the immune system refrains from attacking them. (issels.com)
Advanced non-small cell lung cancer (NSCLC) is the most common type of lung cancer with poor prognosis. (thno.org)
Non-small cell lung cancer (NSCLC), the most common subtype, comprised approximately 85% of the newly diagnosed lung cancer cases [ 2 ]. (thno.org)
Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA. (nwbio.com)
Continuing the research begun under her mentors Garry Nolan, PhD, and Sean Bendall, PhD, Good demonstrated the value of understanding T cell differentiation processes in order to then "guide T cells towards desired outcomes, such as steering T cells towards differentiation states that are more potent in combatting cancer. (stanford.edu)
Merkel cell carcinoma (MCC) is an unusual and highly aggressive skin cancer and often appears in the elderly population. (medscape.com)
Cancer rejection is mostly T cell-mediated. (bmj.com)
Upon mRNA intratumoral injections in the transplantable mouse cancer models CT26, MC38, and B16OVA, potent therapeutic effects were observed following repeated injections into the tumors. (unav.edu)
Recent data demonstrate that the recruitment of dendritic cells to neoplastic lesions (and hence the priming of tumor-specific CD8 + T cells) is highly dependent on radiotherapy dose and fractionation through a mechanism that involves the accumulation of double-stranded DNA in the cytoplasm of cancer cells and consequent type I IFN release. (aacrjournals.org)
The immune system plays a key role in surveillance against cancer, but some tumour cells evolve to escape immune elimination [ 4 ]. (biomedcentral.com)
Abundant evidence indicates that immunodeficiencies are genetic or acquired disorders that predisposes an individual to cancer. (biomedcentral.com)
Overall, single-cell sequencing has immense potential in promoting early diagnosis, guiding personalized treatment, and preventing complications of pancreatic cancer. (frontiersin.org)
Applications of single-cell sequencing technology in the diagnosis and treatment of pancreatic cancer. (frontiersin.org)
However, although these new therapeutic strategies, which are designed to limit immune escape of cancer cells, have been used or tested successfully in many different cancers, a large proportion of patients have been described to resist and not respond to these new treatments. (oaepublish.com)
Specific tumor-associated antigens (TAAs) expressed by cancer cells can be identified by the immune system and results in the activation of immune system effectors and the consequent elimination of the cancer cells. (oaepublish.com)
Examples of direct implication of epigenetic modifications in immune recognition of cancer cells. (oaepublish.com)
This master thesis is a part of a project aiming to set up immunoaffinity-purification/MS based method in order to analyse the ligandome and determine T-cell recognized cancer associated antigens from tumor cells. (helsinki.fi)
Preliminary MTS assay is used to determine linear range and optimal time frame for the PBMC/cancer cell co-culture killing assay. (helsinki.fi)
Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)
Her research involves direct reprogramming approaches, which function like a Trojan horse, enabling cancer cells to be targeted by the immune system. (lu.se)
when it comes to cancer they are critical as they present tumor antigens to the killer cells of the immune system and orchestrate the anti-tumor immune response. (lu.se)

Mammalian cells require oxygen and nutrients for their survival and are therefore located within 100 to 200 m of blood vessels, the diffusion limit of oxygen. (hindawi.com)
We show that treatment of the mice with a combination of anti-CTLA-4 + anti-PD1 mAbs results in partial clearance of the tumor with an improvement in survival. (unav.edu)
In primary tumors, mutations in driver genes frequently provide a survival advantage and give rise to a dominant clonal population. (spandidos-publications.com)

It also allowed me to acquire immunological techniques, such as animal experimentation, mutiparametric flow cytometry, ELIspot, ELISA and lymphoid cells culture. (unil.ch)

Faculty member Garry Nolan, PhD, Genetics 1989, Baxter Labs/Microbiology & Immunology, uses bioinformatics and high-dimensional imaging machines to visualize single cells and measure many characteristics of each cell. (stanford.edu)

Since then, it has been referred to as cutaneous neuroendocrine carcinoma, small cell tumor of the skin, primary undifferentiated carcinoma of the skin, anaplastic carcinoma of the skin, murky cell carcinoma, neuroendocrine tumor of the skin, or cutaneous APUDoma (a tumor composed of cells with amine precursor uptake and decarboxylation [APUD] cytochemical properties). (medscape.com)

Preclinical data demonstrate that multiple immunomodulators synergize with radiotherapy to cause the regression of irradiated tumors and, less often, nonirradiated metastases. (aacrjournals.org)

High-throughput sequencing methods are utilized to analyze the mutational spectrum and evolutionary trajectories of tumor cells. (spandidos-publications.com)

Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
My PhD and previous internships allowed me to acquire immunological knowledge about the monitoring of T cell responses in a tumor context. (unil.ch)

No cell acts independently," he said, "and differentiation is a continuous trajectory -- not a chain of discrete stages, as we once thought. (stanford.edu)
We have an opportunity to intervene at the relevant time points, and perhaps guide T cell differentiation towards a desirable phenotype," Good said. (stanford.edu)
However, distinct tumors differentially regulated this inherent MO-MDSC differentiation program, indicating that this phenomenon was tumor driven. (ashpublications.org)

CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)

Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
Low power, H and E showing a hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)

These fractions consisted of either mononuclear cells (MO-MDSCs), resembling inflammatory monocytes, or low-density polymorphonuclear cells (PMN-MDSCs), akin to immature neutrophils. (ashpublications.org)

In this study, we comprehensively screened HLA-A2 restricted MAGE-A3 tumor epitopes and characterized the corresponding TCRs using in vitro artificial antigen presentation cells (APC) system, single-cell transcriptome and TCR V(D)J sequencing, and machine-learning. (thno.org)

Medigene will contribute its proprietary TCR discovery platform for the development of TCRs against multiple solid tumor targets nominated by BioNTech. (pressetext.com)

Individually, dendritic cells are extremely potent, but the problem is that they're not usually present in large enough quantities. (issels.com)
CD137 (4-1BB) is a member of the TNFR family that mediates potent T cell costimulatory signals upon ligation by CD137L or agonist monoclonal antibodies (mAbs). (unav.edu)

Importantly, T cells artificially expressing the MAGE-A3-Mp4 specific TCRs exhibited strong MAGE-A3+ tumor cell recognition and killing effect. (thno.org)

This work identified candidate TCRs potentially suitable for TCR-T design targeting HLA-A2 restricted MAGE-A3 tumor antigen. (thno.org)
The sale and licensing deal with BioNTech is an important validation from a global leading biotech company of our proprietary technologies to discover and characterize highly specific TCRs and empower resulting TCR-T cells to fight solid tumors. (pressetext.com)

Merkel cells are nondendritic, nonkeratinocytic epithelial cells located primarily in or near the basal layer of the epidermis. (medscape.com)

These cells are then forced to compete for growth and nutrients ( 2 ). (spandidos-publications.com)

Anatomy21

Organisms11

Diseases82

Chemicals and Drugs67

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes38

Disciplines and Occupations1

Information Science4

Health Care6

Microenvironment15

Lymphocytes7

Malignant7

Immunotherapy13

Professional antigen-prese1

Immunity4

Corresponding antigen-specific1

Patient's tumor2

Anti-tumor immune responses2

Carcinoembryonic antigen2

Induce5

Myeloid6

Dendritic cell7

Heterogeneity9

Progression3

Therapies5

Melanoma8

Recognize1

Extracellular3

Clinical7

Metastatic1

Angiogenesis4

Immunosuppressive1

Gene2

Peripheral blood1

Receptor4

Expression6

Receptors1

Mechanisms2

Occurs1

Adoptive1

Effector3

Immunogenic2

Therapy2

Endothelial cells4

Assays1

Recurrence1

Efficacy1

Cancer23

Survival3

ELISA1

Bioinformatics1

Uptake1

Radiotherapy1

Mutational1

Responses2

Differentiation3

Methods1

Tissue2

Monocytes1

Presentation1

Targets1

Potent2

Recognition1

TCRs2

Epithelial1

Nutrients1