AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Stem CellsPeripheral Blood Stem Cell TransplantationHematopoietic Stem Cell TransplantationHematopoietic Stem CellsStem Cell TransplantationTransplantation, AutologousHematopoietic Stem Cell MobilizationTransplantation, HomologousBone MarrowBone Marrow TransplantationEmbryonic Stem CellsBone Marrow CellsAdult Stem CellsCord Blood Stem Cell TransplantationGranulocyte Colony-Stimulating FactorPluripotent Stem CellsGraft vs Host DiseaseTransplantation ConditioningAntigens, CD34LeukapheresisHematologic NeoplasmsStem Cell NicheCell DifferentiationGraft SurvivalNeural Stem CellsInduced Pluripotent Stem CellsMesenchymal Stem Cell TransplantationBlood Component RemovalStem Cell FactorMultipotent Stem CellsTissue DonorsHematopoiesisMelphalanTreatment OutcomeMesenchymal Stromal CellsCombined Modality TherapyCell LineageBusulfanMultiple MyelomaCyclophosphamideCells, CulturedWhole-Body IrradiationImmunosuppressive AgentsFetal BloodHistocompatibility TestingTransplantation ChimeraColony-Forming Units AssayTime FactorsAntineoplastic Combined Chemotherapy ProtocolsHistocompatibilityBlood CellsCell SeparationRecurrenceStem Cell ResearchLeukemiaFlow CytometryPlant StemsCytomegalovirus InfectionsFetal Stem CellsTransplantationBone Marrow PurgingKidney TransplantationRetrospective StudiesBlood Cell CountBone Marrow DiseasesCell ProliferationLymphoma, Non-HodgkinMyeloablative AgonistsRemission InductionMice, Inbred C57BLTransplantsAnemia, AplasticNeoplastic Stem CellsCell Culture TechniquesImmunocompromised HostHematologic DiseasesEtoposideSurvival RateLeukemia, Myeloid, AcuteOpportunistic InfectionsAntineoplastic Agents, AlkylatingRegenerationSurvival AnalysisThiotepaGraft RejectionInfectionDisease-Free SurvivalLeukemia, Myelogenous, Chronic, BCR-ABL PositiveSalvage TherapyAntigens, CDImmunophenotypingMice, SCIDVidarabineNeoplasmsOctamer Transcription Factor-3CyclosporineHodgkin DiseaseBlood DonorsCytarabineFollow-Up Studies
TransplantationGraft-versus-DonorFound in the bone maBiol Blood Marrow TransplantChemotherapyDonorsGrow in the bone maGVHDCord blood transplantsCancersDonor's stem cellsProcedureUmbilical cordImmune systemPatientsMultiple myelomaBloodstreamAutologous stemSpongyType of transplantTransplantationsPlateletsBiopsyTypes of stemAbnormalPediatric BloodPatient's own cellsPerson'sMyeloidLymphocytesRecipientsLeukemiaDoctorsGeneral anesthesiaProgenitorCentersEmbryonicSevereNeed a bone2020OutcomesStromal2021TumorsCancerOrgans
Transplantation51
Graft-versus-6
  • They also report for the first time that having a lower diversity of microbiota before transplant resulted in a higher incidence of graft-versus-host disease. (mskcc.org)
  • One of the most serious complications of blood stem cell or bone marrow transplants (BMTs) , which are used to treat many types of blood cancer, is graft-versus-host disease (GVHD). (mskcc.org)
  • Technicians process stem cells from the donor to elimi-nate alpha-beta T cells, immune cells that instigate graft-versus-host disease. (stanford.edu)
  • My principle research interests are in the prevention and therapy of graft-versus-host disease (GVHD) and in the use of graft-versus-leukemia to eradicate blood disorders. (harvard.edu)
  • Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
Donor34
  • Stem cells are removed from another person, called a donor. (medlineplus.gov)
  • Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
  • Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
  • During leukapheresis, blood is removed from the donor through an IV line. (medlineplus.gov)
  • The red blood cells are returned to the donor. (medlineplus.gov)
  • Stem cells from a donor (also called an allogeneic transplant). (cdc.gov)
  • A transplant using stem cells from a donor increases your risk for fungal infection more than a transplant that uses stem cells from your own body. (cdc.gov)
  • If you receive stem cells from a donor, the transplanted stem cells may attack your body. (cdc.gov)
  • When a person needs a bone marrow transplant, doctors must retrieve and harvest stem cells from that individual or a donor. (popsci.com)
  • In contrast to the expected mixed chimerism that usually occurs in the absence of conditioning, we found in our patients 100% donor cell engraftment based on fluorescence in situ hybridization (FISH) and microsatellite techniques. (nih.gov)
  • Subset analysis of the engrafted cells using a multiparametric system enabling a combined analysis of morphology, immunophenotyping and FISH showed that both T and B lymphocytes and myeloid cells were of donor origin in two patients, while T lymphocytes and myeloid cells were of donor origin in the third. (nih.gov)
  • In the two cases with ABO incompatibility, erythroid engraftment was evidenced by blood group conversion from recipient to donor type. (nih.gov)
  • Researchers also plan to study the safety of providing fecal transplants with material from a healthy donor. (mskcc.org)
  • Allogeneic" means the blood or marrow stem cells come from a donor. (mskcc.org)
  • Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
  • With a bone marrow transplant, the donor receives general anesthesia , and the bone marrow is extracted in a 1-2-hour procedure. (mdanderson.org)
  • With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
  • This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
  • For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
  • Many patients find matched unrelated donors through the National Marrow Donor Program. (mdanderson.org)
  • If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
  • Or, the cells from the donor may recognize the new body as foreign and attack. (mdanderson.org)
  • Stem cell transplants remove blood-forming stem cells from a healthy donor, and then inject them into a patient, where they take hold and grow in the bone marrow. (stanford.edu)
  • As a re-sult, patients can be safely transplanted us-ing stem cells from a donor with only 5 of 10 matching HLA antigens -- such as a parent. (stanford.edu)
  • The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. (medscape.com)
  • In syngeneic transplants, the donor is the identical twin of the recipient. (medscape.com)
  • Allogeneic transplants are further categorized by the degree of human leukocyte antigen (HLA) match between the donor and recipient. (medscape.com)
  • However, the supply of donor-derived islets will never meet the needs of the large number of patients who could potentially benefit from this cell-based therapy. (ohsu.edu)
  • MSCs can promote host tissue repair through several different mechanisms including donor cell engraftment, release of cell signaling factors, and the transfer of healthy organelles to the host. (frontiersin.org)
  • In a little over 4,800 cases, the blood came from an unrelated donor. (healthline.com)
  • Donating bone marrow is relatively low risk for the donor. (healthline.com)
  • The National Marrow Donor Program requires you be between 18 and 40 years old to donate. (healthline.com)
  • Learn more about being a stem cell donor. (medicalnewstoday.com)
  • Then, you receive stem cells from a matched donor. (webmd.com)
Found in the bone ma1
Biol Blood Marrow Transplant1
Chemotherapy27
  • Ablative (myeloablative) treatment -- High-dose chemotherapy, radiation, or both are given to kill any cancer cells. (medlineplus.gov)
  • Reduced intensity treatment, also called a mini transplant -- Lower doses of chemotherapy and radiation are given before a transplant. (medlineplus.gov)
  • Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. (medlineplus.gov)
  • After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)
  • A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)
  • A bone marrow transplant replaces bone marrow that is either not working properly or has been destroyed (ablated) by chemotherapy or radiation. (medlineplus.gov)
  • Right now, GCSFs don't work for some patients who might benefit from autologous stem cell transplants-a procedure where doctors harvest a person's own stem cells and use them to replace their unhealthy bone marrow, that's used in conditions like Hodgkin's lymphoma-because they often don't work in people who have had chemotherapy in the past. (popsci.com)
  • We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
  • Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
  • This study is looking at chemotherapy, radiotherapy and stem cell transplants for people with high risk neuroblastoma. (cancerresearchuk.org)
  • You have a stem cell transplant after you have the high dose chemotherapy. (cancerresearchuk.org)
  • The standard treatment is to give one treatment of high dose chemotherapy and a stem cell transplant. (cancerresearchuk.org)
  • Researchers think that giving an extra treatment of high dose chemotherapy with 2 stem cell transplants might be better. (cancerresearchuk.org)
  • The other half have an extra treatment of high dose chemotherapy and 2 stem cell transplants. (cancerresearchuk.org)
  • Treatments for leukemia include chemotherapy, radiation therapy, and stem cell transplants. (medicalnewstoday.com)
  • Chemotherapy, radiation therapy, targeted therapy, and stem cell or bone marrow transplant are common treatment options for leukemia. (medicalnewstoday.com)
  • Chemotherapy uses drugs to kill cancer cells and slow or stop their growth. (medicalnewstoday.com)
  • Some supportive therapies, such as anti-nausea medications or growth factors to boost blood cell production, may help manage side effects and improve quality of life during chemotherapy. (medicalnewstoday.com)
  • Doctors transplant the donor's stem cells into the individual after chemotherapy or radiation therapy to replace their diseased or damaged stem cells. (medicalnewstoday.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
  • First, you get high doses of chemotherapy drugs to kill blood-forming stem cells in your bone marrow. (webmd.com)
  • The high chemotherapy doses used for transplants have risks. (webmd.com)
  • T-prolymphocytic leukemia (T-PLL) is an aggressive mature T-cell neoplasm that responds poorly to conventional chemotherapy and has a dismal outcome. (haematologica.org)
  • Further, cancer treatment often involves radiotherapy and chemotherapy, which not only kills cancer cells but also affects healthy cells. (aspetjournals.org)
  • Chemotherapy interferes with cancer cells' ability to grow. (bidmc.org)
  • Doctors extract stem cells from your blood or bone marrow, place them in frozen storage, and re-infuse them back into your body following high-dose chemotherapy to eliminate blood cancers. (bidmc.org)
Donors10
  • Donors who are not related to you, yet still match, may be found through national bone marrow registries. (medlineplus.gov)
  • A fast process would also improve the experience for healthy donors who volunteer to give stem cells-which might attract more people. (popsci.com)
  • A method that broadens the pool of potential donors for stem cell transplants recently saved two young brothers from a severe genetic disease. (stanford.edu)
  • Before she came to Stanford, their doctor Alice Bertaina , MD, PhD, developed a technique that greatly reduces the risk of graft vs. host disease and broadens the potential pool of stem cell donors. (stanford.edu)
  • Donors for allogeneic transplants may be related or unrelated to the recipient. (medscape.com)
  • This site provides information, referrals, and support by trained peer volunteers who are transplant survivors, caregivers, and donors. (myeloma.org)
  • People who register as donors agree to donate either bone marrow or PBSC, depending on the recipient's needs. (healthline.com)
  • It can also happen through voluntary registries that seek suitable donors for people in need of a transplant. (healthline.com)
  • Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
Grow in the bone ma2
GVHD2
  • In GVHD, the donated stem cells view the recipient cells as foreign and attack recipient cells. (medscape.com)
  • We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
Cord blood transplants1
Cancers10
  • For many cancers, the donor's white blood cells may attack any remaining cancer cells, which are seen as foreign, similar to when white cells attack bacteria or viruses when fighting an infection. (medlineplus.gov)
  • Our specialists at UCLA Mattel Children's Hospital focus exclusively on caring for children with blood cancers. (uclahealth.org)
  • HSC transplants are used in the treatment of cancers and other immune system disorders. (wikipedia.org)
  • A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
  • Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
  • The transplants were first developed for people with blood cancers, but have the potential to be used much more widely for a variety of genetic diseases. (stanford.edu)
  • Antibody-based hematopoietic stem cell transplants may transform the treatment of patients with blood and immune diseases including cancers. (stanford.edu)
  • p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
  • Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
  • There are more than 70 diseases or conditions-including leukemia, immune system and other blood disorders, cancers, and autoimmune diseases-that respond well when adult stem cell therapy is used. (all.org)
Donor's stem cells1
Procedure4
  • A bone marrow transplant is a procedure to replace damaged or diseased bone marrow with healthy bone marrow stem cells. (medlineplus.gov)
  • The procedure, which was not available at any other U.S. hospital when the brothers received it last year, is now offered to most transplant recipients at Packard Children's. (stanford.edu)
  • What is the procedure for donating bone marrow? (healthline.com)
  • The procedure is based on an autologous bone-marrow transplant (when patients receive a transplant of their own stem cells) and now constitutes a treatment option to cure an intestinal disease that sometimes does not successfully respond to drugs and requires highly complex surgery that does not provide a cure. (sciencedaily.com)
Umbilical cord4
  • Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
  • Umbilical cord blood cells are very immature so there is less of a need for perfect matching. (medlineplus.gov)
  • They are also found in umbilical cord blood and, in small numbers, in peripheral blood. (wikipedia.org)
  • The stem cell source may be bone marrow, peripheral blood, or umbilical cord blood. (medscape.com)
Immune system7
  • Your child's body will rebuild an immune system from scratch with the new, transplanted stem cells. (uclahealth.org)
  • The newly transplanted stem cells are replacing your child's immune system. (uclahealth.org)
  • Sometimes, that transplanted immune system can react against your child's body, attacking its organs. (uclahealth.org)
  • Because stem cell transplants destroy and rebuild your immune system, they increase your risk for fungal infections. (cdc.gov)
  • The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
  • Immunotherapy - This is a relatively new and innovative way of using the body's own immune system to target the cancer cells. (iuhealth.org)
  • From there, they travel to the bone marrow and multiply, rebuilding a person's immune system . (medicalnewstoday.com)
Patients27
  • Some types of fungal infections are more common than others in stem cell transplant patients. (cdc.gov)
  • Aspergillosis is the most common type of fungal infection in stem cell transplant patients, followed by Candida infection and mucormycosis, but other types of fungal infections are also possible. (cdc.gov)
  • Some patients may benefit from blood tests to detect fungal infections like aspergillosis before symptoms appear. (cdc.gov)
  • The drugs also can't be used in patients with sickle cell disease. (popsci.com)
  • We studied three SCID patients who were transplanted with unmodified mobilized peripheral blood from HLA-identical family sex-mismatched members. (nih.gov)
  • Patients who went into the BMT process with a gut flora that was already disrupted had a higher risk of death after the transplant," says the study's senior author, Marcel van den Brink. (mskcc.org)
  • The thing that we keep coming back to is that preserving the commensal flora in the microbiome is good for transplant patients. (mskcc.org)
  • But traditional stem cell transplants are so risky that they've usually been offered only to patients who would otherwise die. (stanford.edu)
  • Bone marrow aspiration and biopsy with cytogenetic studies are required in most, but not all, patients. (medscape.com)
  • Patients with CLL typically have a higher-than-normal white blood cell count, which is determined by a complete blood count (CBC). (medscape.com)
  • MSC co-culture with skin fibroblasts from mitochondrial disease patients rescued aberrant mitochondrial morphology from a fission state to a more fused appearance indicating an effect of MSC co-culture on host cell mitochondrial network formation. (frontiersin.org)
  • BMT InfoNet provides emotional support and information about bone marrow and peripheral blood stem cell transplants to patients and their loved ones. (myeloma.org)
  • This site provides information for patients and their families ranges from data about transplant outcomes to best practices in follow-up care for patients post-transplant. (myeloma.org)
  • This site provides information about bone marrow or cord blood transplant process for patients, their families, and health care providers. (myeloma.org)
  • We offer advanced treatments like CAR T-cell therapy that result in excellent survival rates for our patients, and our program is recognized as a Top 50 Children's Cancer Program by U.S. News & World Report for 2023-2024. (hopkinsmedicine.org)
  • Complete normalization of hemoglobin (complete and major hematological response), is seen in no more than one third of patients, while the remaining continue to experience some degree of anemia (good and partial hematological responses), in some cases requiring regular red blood cell transfusions (minor hematological response). (frontiersin.org)
  • Bone marrow transplants for cancer patients, which rely on blood stem cells, fulfill this potential. (truthdig.com)
  • Scientists are exploring an innovative cellular therapy that uses stem cells to treat Crohn's disease, a chronic genetic disease which has considerable impact on the quality of life of the patients. (sciencedaily.com)
  • In this line, Hospital Clínic, Barcelona is exploring an innovative cellular therapy that uses stem cells to treat Crohn's disease, a chronic genetic disease that affects 1% of the population in Spain and which has considerable impact on the quality of life of the patients. (sciencedaily.com)
  • With this therapy, in an average follow-up period of 6 years, 80% of transplant patients are in a phase of total remission of the disease and the remaining 20% have shown considerable improvement following the transplant, and are now responding favorably to drugs. (sciencedaily.com)
  • The transplant requires several weeks of admission to hospital before patients receive their own cells. (sciencedaily.com)
  • in Italy, the treatment has been applied to 4 patients, 3 of whom are also showing excellent progress following the transplant. (sciencedaily.com)
  • 1 Patients with active T-PLL present with an exponential rise of post-thymic T cells with prolymphocytic morphology, hepatosplenomegaly, skin rash, lymphadenopathy, and effusions. (haematologica.org)
  • CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells from MDS patients against primary MDS and MDSC CD33+ targets. (stembook.org)
  • The drug of choice for prevention of CMV disease in solid-organ transplant patients is valganciclovir. (medscape.com)
  • Patients can be cured with bone marrow transplantations of haematopoietic stem cells. (lu.se)
  • The key to these cells' utility is their ability to differentiate into many different cell types depending on the stimulus received and they have been used in treatments for diseases such as cancer and neural degeneration, in rehabilitation of tetraplegic and paraplegic patients and even in dentistry 1 . (bvsalud.org)
Multiple myeloma2
Bloodstream7
  • The stem cells are delivered into your bloodstream, usually through a tube called a central venous catheter. (medlineplus.gov)
  • The team found that a combination of Viagra and a stem cell mobilizer called Plerixafor were able to pull stem cells out of the bone marrow and into the bloodstream (like GCSF's do), where they could be easily harvested. (popsci.com)
  • Smith-Berdan and Forsberg study the mechanisms that help stem cells move in and out of the bone marrow, and in previous research, found that the more permeable the blood vessels around the bone marrow were, the more easily stem cells moved into the bloodstream. (popsci.com)
  • It's probably a good thing that Viagra alone didn't move stem cells into the bloodstream, Forsberg says. (popsci.com)
  • New blood cells (called "stem cells") begin in the bone marrow - the red spongy material found inside the bones - and are released to the bloodstream when mature. (nemours.org)
  • Doctors then infuse the stem cells back into the bloodstream. (medicalnewstoday.com)
  • Injected into a joint or spine, or delivered intravenously into the bloodstream, Greene told his listeners, those cells could ease whatever ailed them. (truthdig.com)
Autologous stem2
Spongy2
Type of transplant1
  • There are different reasons for receiving either type of transplant. (cdc.gov)
Transplantations2
  • The Bone Marrow Transplant team at Apollo Gleneagles Cancer Hospital is led by Dr Suparno Chakrabarti, one of the world renowned bone marrow transplant specialists and has been involved in evolving newer modalities of bone marrow transplantations for over a decade. (apollohospitals.com)
  • When it comes to hematopoietic stem cell transplantations, these are the important cells. (lu.se)
Platelets4
Biopsy4
  • The cells can be removed as liquid (to perform a smear to look at the cell morphology) or they can be removed via a core biopsy (to maintain the architecture or relationship of the cells to each other and to the bone). (wikipedia.org)
  • Other tests that may be helpful for diagnosis include bone marrow biopsy and ultrasonography of the liver and spleen. (medscape.com)
  • biopsy - either a bone marrow biopsy to examine blood cells, or a surgical or CT-guided biopsy to obtain lymph node tissue samples. (bidmc.org)
  • Our radiologists report on your imaging studies and our hematopathologists (pathologists who specialize in blood diseases) review the results of your biopsy. (bidmc.org)
Types of stem4
Abnormal9
Pediatric Blood1
Patient's own cells1
  • One potentially fatal complication, graft vs. host disease , occurs when the new, donated cells respond to the immune markers on a patient's own cells -- known as HLA antigens -- as if they are foreign, and mount an immune attack against the patient's body. (stanford.edu)
Person's1
  • Now, for the first time, investigators have found an association between the health of the microbiota before a transplant and a person's survival afterward. (mskcc.org)
Myeloid5
Lymphocytes2
Recipients1
  • If given in tandem with solid-organ transplants, they could also remove the need for immune-suppressing therapy in organ recipients. (stanford.edu)
Leukemia14
  • Myeloproliferative diseases are a heterogeneous group of disorders characterized by cellular proliferation of one or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. (medscape.com)
  • Bone marrow fibrosis is also detected in the spent phase of chronic myelogenous leukemia and polycythemia vera. (medscape.com)
  • The killing of leukemia cells is proportional to the radiation absorbed dose. (nature.com)
  • Our blood cancer specialists see several hundred children with leukemia every year. (hopkinsmedicine.org)
  • Without enough healthy white blood cells, children with leukemia are less able to fight off infection. (hopkinsmedicine.org)
  • As leukemia cells multiply, they interfere with the production of healthy blood cells and bone marrow function. (hopkinsmedicine.org)
  • Using a thin, hollow needle, we remove bone marrow samples to check for signs of leukemia. (hopkinsmedicine.org)
  • We use a thin, hollow needle to remove a spinal fluid sample and check it for leukemia cells. (hopkinsmedicine.org)
  • Refractory ALL is a more challenging form of leukemia because the cancer cells have become resistant to standard treatments. (medicalnewstoday.com)
  • 1 T-PLL cells commonly demonstrate rearrangements involving T-cell leukemia/lymphoma 1 (TCL1) family genes TCL1A, MTCP1 (mature T-cell proliferation), or TCL1B as molecular hallmarks. (haematologica.org)
  • Acute lymphoblastic leukemia (ALL), also called acute lymphocytic leukemia, is a cancer of the white blood cells. (bidmc.org)
  • Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. (medscape.com)
  • Analyzing samples from 805 children with newly diagnosed ALL from three consecutive clinical trials, we determined the ex vivo sensitivity of primary leukemia cells to 18 therapeutic agents across 23 molecular subtypes defined by leukemia genomics. (cdc.gov)
  • Leukemia sensitivity to these two agents was highly associated with MRD although with distinct patterns and only in B cell ALL. (cdc.gov)
Doctors2
  • MSK doctors are already conducting research on fecal transplants that make use of a patient's own stool. (mskcc.org)
  • Doctors can deliver radiation externally or internally, depending on the location of the cancer cells. (medicalnewstoday.com)
General anesthesia1
  • Bone marrow harvest -- This minor surgery is done under general anesthesia . (medlineplus.gov)
Progenitor10
  • Stem and progenitor cells can be taken from the pelvis, at the iliac crest, using a needle and syringe. (wikipedia.org)
  • It was used extensively in early studies, but is now considered to measure more mature progenitor or transit-amplifying cells rather than stem cells[citation needed]. (wikipedia.org)
  • Areas of research focus are beta cell replacement therapies for the treatment of diabetes, the identification of lung progenitor cell populations involved in lung repair, and in the diagnosis of pancreatic cancer. (ohsu.edu)
  • Stem/progenitor cells offer the promise that transplantable beta cells may be generated in the laboratory. (ohsu.edu)
  • To deliver on that promise, our laboratory is collaborating with the laboratories of Markus Grompe, M.D., OHSU, and Gordon Keller, Ph.D., University Health Network, Toronto, Canada, in the development and characterization of monoclonal antibodies directed against cell surface molecules expressed by pancreatic cell subsets as well as pancreatic progenitor cells derived from pluripotent stem cells. (ohsu.edu)
  • This project focuses on the compelling need to generate cell-surface marker specific reagents useful for identification, study, and isolation of pulmonary stem/progenitor cells. (ohsu.edu)
  • 2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
  • Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
Centers1
  • The expanded analysis now includes 8,767 stool samples from 1,362 people who have had allogeneic stem cell or bone marrow transplants at four centers around the world. (mskcc.org)
Embryonic12
Severe2
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by complement-mediated intravascular hemolysis, bone marrow failure, and severe thrombophilia ( 1 ). (frontiersin.org)
  • When a person has sickle cell disease, they experience severe pain every day. (medlineplus.gov)
Need a bone1
  • About 18,000 people each year need a bone marrow or cord blood transplant to treat a life threatening illness. (healthline.com)
20201
Outcomes1
Stromal4
  • Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
  • 6 In addition, independent annexin V/Hoechst assays of primary T-PLL cells on NK-Tert stromal support demonstrated modest single-agent activity of ibrutinib ( Figure 1D , Online Supplementary Figure S2A ). (haematologica.org)
  • Bone marrow appears to contain three stem cell populations: hematopoietic stem cells, stromal stem cells and endothelial precursor cells. (bvsalud.org)
  • Stromal cells are a mixed population that can create bone, cartilage and fat and also fibrous and connective tissues. (bvsalud.org)
20213
Tumors1
  • Trial organizers announced that the first participant had been treated using immune cells with four base-edited genes, equipping the cells to better target and destroy tumors. (cdc.gov)
Cancer24
  • As cancer cells grow, they can make a person weaker, harm organs and bones, and make it hard for the body to fight off other illnesses. (kidshealth.org)
  • But most cases of childhood cancer happen because of random mutations (changes) in the genes of growing cells. (kidshealth.org)
  • Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among the largest and most respected in the world. (nemours.org)
  • One recently developed reagent recognizes a molecule associated with human pancreatic cancer cells as well as precancerous lesions of the pancreas. (ohsu.edu)
  • Eastern India's first dedicated comprehensive Bone Marrow Transplant Unit was launched by Dr. Preetha Reddy, Managing Director, Apollo Hospitals Group at Apollo Gleneagles Cancer Hospital, the only super specialty Cancer hospital in the region. (apollohospitals.com)
  • The Bone Marrow Transplant Unit at Apollo Gleneagles Cancer Hospital is the only dedicated comprehensive BMT in the region. (apollohospitals.com)
  • The bone marrow transplant is the last alternative generally recommended by the physicians in the cases of fatal bone marrow diseases and bone or skin cancer. (powershow.com)
  • At Johns Hopkins All Children's Cancer & Blood Disorders Institute in St. Petersburg, Florida, our team helps you navigate this new world as smoothly as possible. (hopkinsmedicine.org)
  • For more information on how the team in the Cancer and Blood Disorders Institute at Johns Hopkins All Children's Hospital can help your child, please give us a call. (hopkinsmedicine.org)
  • It's sent to a lab and tested for cancer cells. (uhhospitals.org)
  • Cancer cells use the sugar faster than normal cells, so it collects in cancer cells. (uhhospitals.org)
  • A PET scan can sometimes show cancer cells in different parts of the body, even when they can't be seen on other tests. (uhhospitals.org)
  • This test may be done to see if cancer cells have reached the bone marrow. (uhhospitals.org)
  • When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)
  • They aim to eliminate cancer cells from the blood. (medicalnewstoday.com)
  • Radiation therapy is a cancer treatment that uses high-energy radiation to destroy cancer cells. (medicalnewstoday.com)
  • External radiation therapy involves delivering radiation to the cancer cells from outside the body using a linear accelerator. (medicalnewstoday.com)
  • However, it does not mean a complete cure, as some cancer cells may remain in the body and can cause the disease to return. (medicalnewstoday.com)
  • Transporters on the plasma membrane of tumor cells are promising molecular "Trojan horses" to deliver drugs and imaging agents into cancer cells. (aspetjournals.org)
  • mIBG enters cancer cells through the norepinephrine transporter (NET) where the radioactive decay of 131 I causes DNA damage, cell death, and tumor necrosis. (aspetjournals.org)
  • Understanding the molecular mechanisms governing mIBG transport in cancer and normal cells is a critical step for developing strategies to optimize the efficacy of 131 I-mIBG while minimizing toxicity in normal tissues. (aspetjournals.org)
  • For instance, the use of 131 I radiotherapy to treat thyroid cancer is highly dependent on the selective expression of the sodium/iodine symporter on these cells ( Kogai and Brent, 2012 ). (aspetjournals.org)
  • At BIDMC, we review all of your information with the full blood cancer treatment team in our weekly multidisciplinary conferences. (bidmc.org)
  • Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
Organs3
  • In this condition, a donor's immune cells attack the vital organs of a transplant recipient. (mskcc.org)
  • Hodgkin lymphoma cells can also spread (metastasize) to other organs and tissues. (uhhospitals.org)
  • For more than half a century, the regenerative possibilities of stem cells - which the body stores to repair damaged tissue and organs and restore blood supply - have tantalized the medical community. (truthdig.com)