Cell transplantation clinical bone marrow transplantation. Medical search. Frequent questions

high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
The first recording of a successful bone marrow transplant, dates back to 1956 by dr. (wikipedia.org)
Are you scheduled for a stem cell transplant with cord blood? (nih.gov)
Gassas A , Grant R , Richardson S , Dupuis LL , Doyle J , Allen U , Predictors of viridans streptococcal shock syndrome in bacteremic children with cancer and stem-cell transplant recipients. (cdc.gov)
Bone marrow/stem cell transplantation , including traditional and reduced-intensity transplant, using related, unrelated or umbilical cord blood cells for transplant. (dana-farber.org)
A bone marrow transplant is a procedure that replaces a person's faulty bone marrow stem cells. (medlineplus.gov)
It also suppresses your body's immune system so that it won't attack the new stem cells after the transplant. (medlineplus.gov)
What Is a Bone Marrow Transplant? (medlineplus.gov)
Tandem Autologous Hematopoietic Cell Transplantation for Patients with Primary Progressive or Recurrent Hodgkin Lymphoma: A SWOG and Blood and Marrow Transplant Clinical Trials Network Phase II Trial (SWOG S0410/BMT CTN 0703). (cityofhope.org)
Biol Blood Marrow Transplant. (cityofhope.org)
Craig A. Mullen, M.D., Ph.D. , Jeffrey R. Andolina, M.D. and Lauren B. Bruckner, M.D., Ph.D. are developing state-of-the-art clinical research programs for bone marrow transplantation, including the use of haploidentical blood stem cell donors for patients who need a bone marrow transplant but lack a suitable donor. (rochester.edu)
p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
Novice nurses with limited pediatric clinical experience and no stem cell transplant experience. (aphon.org)
Experienced nurses who don't have hematology, oncology, bone marrow transplant (BMT), or pediatric experience. (aphon.org)
These nurses may know adult stem cell transplant, but have not cared for pediatric patients. (aphon.org)
Then, in 2013, I joined the adult bone marrow transplant team as a newly graduated physician assistant. (mskcc.org)
As a member of the transplant team, I work closely with doctors, other physician assistants, nurse practitioners, nurses, and support staff to care for patients undergoing stem cell transplantation. (mskcc.org)
She has advanced training in immunology and is interested in how the immune system recovers after bone marrow transplant. (ohsu.edu)
The purpose of this study is to assess the effect your disease and the treatment of allogeneic stem cell transplant has upon you before and after your treatment process through questionnaires at certain time points. (mayo.edu)
The primary purpose of this study is to demonstrate the feasibility of sublingual (SL) administration of tacrolimus in blood and marrow transplant (BMT) patients. (mayo.edu)
The aim of this study is to measure the differences in quality of life and mood of hematopoietic stem cell transplant (HCT) patients and their caregivers staying at a hospital hospitality house (HHH), such as the Gift of Life Transplant House, the Help in Healing Home, and the Gabriel House of Care versus staying at a hotel/rental apartment or house. (mayo.edu)
Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
Regret was measured using a FACT-BMT item not included in scoring: "I regret having the bone marrow transplant. (cdc.gov)

Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)
To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
A respected specialist in the field, Dr. Smith is a professor and chair of City of Hope's Department of Hematology & Hematopoietic Cell Transplantation . (cityofhope.org)
This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)

In addition to conventional treatment approaches, you may have the opportunity to participate in clinical trials that offer access to new, innovative treatments for your type of cancer. (dana-farber.org)
Children's Oncology Group: Under the leadership of Jeffrey R. Andolina, M.D. , the Division participates as a full member of this national cooperative group of pediatric cancer researchers- allowing our patients to participate in ongoing clinical trials and receive cutting-edge diagnostic studies and treatments. (rochester.edu)
The Food and Drug Administration (FDA) has announced that breast implants filled with silicone gel may only be used in clinical trials. (stopgettingsick.com)
She is a trial pathologist for clinical trials in transplantation and glomerulonephritis, both industry and grant-funded. (kcl.ac.uk)
Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
However, there are still questions waiting for answers and results of large-scale randomized trials are needed for the appearance of myocardial cellular therapy as a clinical therapeutic option for patients with ischemic heart disease. (escardio.org)
Dr. Appelbaum works with WM patients in the context of stem cell transplantation, and was involved with the very first clinical trials of anti-CD20 antibodies (rituximab) and their early application to WM. (iwmf.com)
It is led by the Leeds Institute of Clinical Trials Research part of the University s School of Medicine with funding from Millennium Pharmaceuticals Inc (Takeda). (leeds.ac.uk)
Gordon Cook, Professor of Haematology and Myeloma Studies and Clinical Director (Haematology) at Leeds Institute of Clinical Trials Research, said: This is the only trial globally looking to test if a clinical score can identify vulnerable patients at risk of treatment-related toxicity and modifying how we deliver therapy up-front rather than in response to developing side effects, which is the standard of care. (leeds.ac.uk)
But research progressed and different trials explore the clinical potential of human MSCs isolated from bone marrow but also from other tissues including adipose tissue. (hindawi.com)
August 24, 2023 - Several new clinical trials in prostate cancer have opened in recent months. (nih.gov)
June 1, 2023 - ComboMATCH will comprise numerous phase 2 precision medicine cancer treatment trials that aim to identify promising drug combinations that can advance to larger clinical trials. (nih.gov)
The current US clinical trials, listed in ClinicalTrials.gov , are dependent upon the fact that parents chose to preserve their child's umbilical cord blood at the time of birth. (parentsguidecordblood.org)
Her main area of research interest is cellular therapy, in which she has clinical trials running and listed in ClinicalTrials.gov. (parentsguidecordblood.org)
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. (biomedcentral.com)
At the same time, the first three trials using cells derived from pluripotent cells have begun. (biomedcentral.com)
The rapid advance of stem cell clinical trials for a broad spectrum of conditions warrants an update of the review by Trounson (2009) [ 1 ]. (biomedcentral.com)
There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
Several of those are now considered applicable for patient treatments beyond the need for regulated clinical trials. (biomedcentral.com)
We have chosen to concentrate on the emerging therapeutics that broadly involves a wide range of cell types in clinical trials registered on the National Institutes of Health's clinical trials web site. (biomedcentral.com)
The public clinical trials database http://clinicaltrials.gov shows 123 clinical trials using MSCs for a very wide range of therapeutic applications (Figure 1 ), the majority of which are in Phase I (safety studies), Phase II (proof of concept for efficacy in human patients), or a mixture of PhaseI/II studies (Figure 2 ). (biomedcentral.com)
Within 5 years, the company expects to have two compounds in clinical trials. (the-scientist.com)
His approach is to put into clinical trials new treatments developed in the laboratory for patients with blood stem cell diseases or cancers of the bone marrow and blood. (uclahealth.org)
The evidence basis is primarily derived from clinical trials, but data can also be extracted from alternate sources such as national or regional data registries. (lu.se)
Next, we will explore the possibility of combining clinical trials and registry data, by using registry infrastructure to conduct simplified randomized trials. (lu.se)

A new clinical intervention trial aims to improve outcomes for patients with the bone marrow cancer multiple myeloma (MM). (leeds.ac.uk)
Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
Dr. Schiller is a well-published clinical investigator in acute and chronic leukemias, multiple myeloma, and other hematologic malignancies, as well as in stem cell and bone marrow transplantation. (uclahealth.org)
His research projects include clinical studies of new drugs, therapies, and bone marrow/stem cell transplantation for patients with malignancies of the blood or bone marrow such as leukemia, multiple myeloma, and lymphoma. (uclahealth.org)
He has also carried out work with purified stem cell transplantation for multiple myeloma. (uclahealth.org)

3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
Consequently, we proceeded with salvage chemotherapy followed by autologous stem cell transplantation. (karger.com)
OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)

Although such attempts produced no positive benefit, further research found in the mid twentieth century that human cells could be used to help prevent the human body rejecting transplanted organs, leading in time to successful bone marrow transplantation as has become common practice in treatment for patients that have compromised bone marrow after disease, infection, radiation or chemotherapy. (wikipedia.org)
Today, more than 50 years after the first successful bone marrow transplantation, clinical application of hematopoietic stem cells is a routine procedure, saving the lives of many every day. (hindawi.com)

Or you can get cells from a donor. (medlineplus.gov)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
First and the most important requirement for stem cell transplantation in sickle cell anaemia is a HLA match sibling donor. (ndtv.com)
Three months after osteoblast engraftment (1.5-2.0% donor cells), representative specimens of trabecular bone showed histologic changes indicative of new dense bone formation. (nih.gov)
The supplement with compatible donor of islets in order to transplantation purpose is very limited. (alliedacademies.org)
Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
The 24-year-old woman, who was registered as a volunteer donor in the German Bone Marrow Donor Registry, was selected. (cdc.gov)
A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)

Bone marrow transplants are the most common and well established cell transplantation therapies. (wikipedia.org)
Craig A. Mullen, M.D., Ph.D. leads a laboratory that studies the interaction of leukemia cells with supportive elements in the bone marrow in order to develop therapies that will interfere with leukemia survival and prevent relapse. (rochester.edu)
Beside unique operative techniques adjuvant regenerative therapies may improve clinical results. (ivis.org)
We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies. (hindawi.com)
His clinical and translational research is on the immunology and immunotherapy of blood cancers and the immunology of new drug therapies in acute and chronic leukemias including HCL, myeloma and lymphoma, and the immunology of allogeneic transplantation and bone marrow failure. (lls.org)
There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)

This study is comparing long-term outcomes for patients who receive blood and bone marrow transplants and those who receive standard treatment with medicines. (nih.gov)
Suzie A. Noronha, M.D. conducts research as part of a national network of experts in sickle cell disease, to improve symptom control, disease outcomes and access to care for these patients. (rochester.edu)
Trusted clinical technology and evidence-based solutions that drive effective decision-making and outcomes across healthcare. (wolterskluwer.com)
Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
Research shows that patients who receive intensive therapy including stem cell transplantation have the best outcomes, with younger and fitter patients generally living more than six years after diagnosis. (leeds.ac.uk)
Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder. (nih.gov)
In this study we seek to investigate the implications of loss of gut microbiota diversity by correlating them with long-term clinical outcomes in alloHSCT recipients. (mayo.edu)
Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)
In the current study, the authors investigated whether patients expressed regret after undergoing HCT and the relationships between clinical outcomes and quality of life. (cdc.gov)

Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)

30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
Cisplatin-based chemotherapy for ovarian germ cell malignancies: the Australian experience. (kaiserpermanente.org)
Dr. Saultz specializes in caring for adults with myeloid malignancies and leukemia that require bone marrow transplantation. (ohsu.edu)
Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)

She was trained in Pediatrics from 1993 to 1996 and then in Clinical Hematology from 1996 to 1998 in the University Hospital "Dr. José E. González" of the same University at Monterrey. (parentsguidecordblood.org)

Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)

At post transplantation day plus 3, antibiotic drug therapy was switched from piperacillin/tazobactam to meropenem. (cdc.gov)

Dr. Appelbaum is the Executive Vice President and Clinical Research Professor at Fred Hutch Cancer Center (Seattle, WA) and author of " Living Medicine: Don Thomas, Marrow Transplantation, and the Cell Therapy Revolution " (2023). (iwmf.com)
July 27, 2023 - Trial results show that engineered T cells can effectively target mesothelin, a protein found on many solid tumors. (nih.gov)
May 15, 2023 - NIH-funded clinical trial will determine safety, tolerability of experimental drug. (nih.gov)
April 4, 2023 - Medication is the first to reduce bone-weakening process in patients with fibrous dysplasia. (nih.gov)
January 11, 2023 - The initial treatment used for some younger women with an aggressive form of breast cancer may be about to change, based on results of a new clinical trial. (nih.gov)

However, there are two main principles by which cells facilitate therapeutic action: Stem, progenitor, or mature cell engraftment, differentiation, and long-term replacement of damaged tissue. (wikipedia.org)
CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)
Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
In principle, transplantation of mesenchymal progenitor cells would attenuate or possibly correct genetic disorders of bone, cartilage and muscle, but clinical support for this concept is lacking. (nih.gov)
Thus, allogeneic bone marrow transplantation can lead to engraftment of functional mesenchymal progenitor cells, indicating the feasibility of this strategy in the treatment of osteogenesis imperfecta and perhaps other mesenchymal stem cell disorders as well. (nih.gov)
However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
At the same time, by asymmetric cell division or after specific activation, stem cells must be able to generate more mature progenitor cells or differentiated effector cells (Figure 1 ). (hindawi.com)
They display differentiation capacities and therefore qualify as multipotent progenitor cells (Figure 1 ). (hindawi.com)

2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)

Annually an estimated 18,000 patients require potentially life-saving bone marrow transplants in the US. (wikipedia.org)

E Donnall Thomas, who treated a leukemia patient with their twin-siblings bone marrow. (wikipedia.org)
In general, for patients presenting damaged or destroyed bone marrow, for example after chemotherapy and/or radiation for acute myeloid leukemia (AML), bone marrow derived cells can be infused into the patients blood stream. (wikipedia.org)
The killing of leukemia cells is proportional to the radiation absorbed dose. (nature.com)
Jessica Shand, M.D., M.H.S. leads a laboratory that studies how leukemia cells promote their own survival by sending signals to tumor environment that are misinterpreted by the immune system. (rochester.edu)
To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)
In particular, she studies the interplay between leukemia cells and natural killer (NK) cells in times of remission and viral challenge. (ohsu.edu)
This current project seeks to understand the prognostic inter-relationship between the immunologic and genomic signatures in Hairy Cell Leukemia. (lls.org)
This was the first example of a successful SC therapy, and is still commonly used today for blood and bone-marrow-related cancers such as leukemia and myeloma. (parentsguidecordblood.org)
He has carried out studies of stem cell transplantation following high-dose chemotherapy and radiation for acute myelogenous leukemia, one of the most common types of leukemia in adults. (uclahealth.org)
Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia. (bvsalud.org)
Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. (cdc.gov)
TET2 Mutation in Adult T-Cell Leukemia/Lymphoma. (cdc.gov)
Adult T cell leukemia aggressivenness correlates with loss of both 5-hydroxymethylcytosine and TET2 expression. (cdc.gov)
Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma. (cdc.gov)
Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma. (cdc.gov)
Absence of FLT3 mutations in Iranian adult T-cell leukemia/lymphoma patients. (cdc.gov)

We report a case of primary large B cell-type pituitary lymphoma in a 47-year-old immunocompetent female who presented with headache and cranial nerve palsy. (karger.com)
To our knowledge, this is the first reported case of primary pituitary lymphoma that relapsed exclusively in the bone marrow and presented with clinical findings of idiopathic anasarca. (karger.com)
Primary lymphoma of the pituitary: an emerging clinical entity. (karger.com)
Liu JK, Sayama C, Chin SS, Couldwell WT: Extranodal NK/T-cell lymphoma presenting as a pituitary mass. (karger.com)
Aho R, Ecfor T: Pathogenesis of primary central nervous lymphoma: invasion of malignant lymphoid cells into and within the brain parenchyma. (karger.com)
Fleming WH, Murphy PR, Murphy LJ, Hatton TW, Matusik RJ, Friesen NG: Human growth hormone induces and maintains cmyc gene expression in Nb2 lymphoma cells. (karger.com)
Management of acute and chronic leukaemia, myeloma, lymphoma and autologous/allogeneic haematopoietic stem cell transplantation. (materonline.org.au)
Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
he also has studies going on in certain kinds of non-Hodgkin's lymphoma and Sickle Cell Anemia. (uclahealth.org)
2. Clinical epidemiology - using data from the Swedish Lymphoma Registry to provide clinically useful real world data on treatment and prognosis, in many cases in collaboration with Nordic colleagues. (lu.se)
Missense mutation with/without nonsense mutation of the p53 gene is associated with large cell morphology in human malignant lymphoma. (cdc.gov)

As a patient in the Center for Hematologic Oncology, you will be treated by a dedicated care team that includes oncologists, surgeons, hematologists, physician assistants, nurses and clinical social workers who are committed to delivering high-quality, safe, patient care. (dana-farber.org)
Eileen P. Smith, M.D., has spent nearly three decades at City of Hope, beginning in 1988 as a fellow in medical oncology and bone marrow transplantation. (cityofhope.org)
Clinical haematology and haemato-oncology only. (materonline.org.au)
Adjuvant therapy of ovarian germ cell tumors with cisplatin, etoposide, and bleomycin: a trial of the Gynecologic Oncology Group. (kaiserpermanente.org)
In: Journal of Cancer Research and Clinical Oncology Jg. (uni-due.de)

Bone Marrow Transplantation (2000) 25, 807-813. (nature.com)

Breast cancer, a common cancer in women, is a disease in which cancer (malignant) cells are found in the tissues of the breast. (stopgettingsick.com)
malignant haematological disorders, lymphomas, acute and chronic leukaemias, myeloma and stem cell transplantation as well as non-malignant haematology - thrombosis and haemostasis, obstetric haematology and red cell disorders. (materonline.org.au)
Treatment malignant haematological disorders including bone marrow / stem cell transplantation. (materonline.org.au)
Some studies have found that size and histology were the major factors determining prognosis for patients with malignant mixed germ cell tumors of the ovary. (kaiserpermanente.org)
Gershenson DM: Update on malignant ovarian germ cell tumors. (kaiserpermanente.org)
Norris HJ, Zirkin HJ, Benson WL: Immature (malignant) teratoma of the ovary: a clinical and pathologic study of 58 cases. (kaiserpermanente.org)
Kurman RJ, Norris HJ: Malignant germ cell tumors of the ovary. (kaiserpermanente.org)
Malignant ovarian germ cell tumors: identification of novel prognostic markers and long-term outcome after multimodality treatment. (kaiserpermanente.org)
An increased risk for the development of malignant neoplasias in individuals with Fanconi Anemia has been reported, and this is progressive after bone marrow transplantation. (bvsalud.org)

Cell therapy (also called cellular therapy, cell transplantation, or cytotherapy) is a therapy in which viable cells are injected, grafted or implanted into a patient in order to effectuate a medicinal effect, for example, by transplanting T-cells capable of fighting cancer cells via cell-mediated immunity in the course of immunotherapy, or grafting stem cells to regenerate diseased tissues. (wikipedia.org)

Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
The purpose of this study is to measure the effect of Hematopoietic Stem Cell Transplantation (HSCT) on symptoms of CSF1R-related Leukoencephalopathy. (mayo.edu)
To characterize the clinical and epidemiological profile of children and adolescents submitted to HSCT at a referral service in the state of Rio Grande do Norte. (bvsalud.org)
This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)

p>In addition to childhood cancers and blood disorders, Nemours treats nonmalignant bone marrow disorders, immune system deficiencies and some metabolic disorders with allogeneic blood and bone marrow transplantation. (nemours.org)

In recent decades, however, stem cell and cell transplantation has gained significant interest by researchers as a potential new therapeutic strategy for a wide range of diseases, in particular for degenerative and immunogenic pathologies. (wikipedia.org)
However, in many diseases and disorders, cell are compromised by e.g. senescence, limited blood supply (ischemia), inflammation, or simply a reduction in the number of cells. (wikipedia.org)
When germ-free cell cultures became a laboratory routine, hopes were high for using this novel technology for treatment of diseases or replacement of cells in patients suffering from injury, inflammation, or cancer or even refreshing cells in the elderly. (hindawi.com)
Intellia believes the CRISPR/Cas9 technology has the potential to transform medicine by both producing therapeutics that permanently edit and/or correct disease-associated genes in the human body with a single treatment course, and creating enhanced engineered cells that can treat oncological and immunological diseases. (newswise.com)
More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)
The best and first application for [iPSCs] is really to change the paradigm of drug discovery," says John Walker, chief executive of iZumi Bio, a South San Francisco-based biotech company focused on using reprogrammed skin cells from patients to screen for new drug compounds to treat neurodegenerative diseases, such as spinal muscular atrophy, amyotrophic lateral sclerosis, and Parkinson's disease. (the-scientist.com)
Some of these diseases develop mainly after bone marrow transplantation. (bvsalud.org)

3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)

In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)

Cutaneous manifestations in patients with Wiskott-Aldrich syndrome submitted to haematopoietic stem cell transplantation. (medscape.com)
All blood cells originate from a population of relatively few haematopoietic stem cells residing in the bone marrow, which give rise to specific progenitors through different lineages. (lu.se)
This computational approach to the haematopoietic system is novel and provides insight into the dynamics and the nature of possible solutions, with potential applications in both fundamental and clinical research. (lu.se)

Furthermore, we show expression of MSTN by CML mesenchymal stromal cells, and that myostatin propeptide has a direct and instant effect on CML cells, independent of myostatin, by demonstrating binding of myostatin propeptide to the cell surface and increased phosphorylation of STAT5 and SMAD2/3. (haematologica.org)
Overview of studies published regarding MSCs using the term "stem cell" or "stromal cell" in the last 20 years accessed by a web search in July 2015 (Google Scholar). (hindawi.com)
Nowadays, experts agree that MSCs may generate upon appropriate stimulation quite different mature cells including osteoblasts, chondrocytes, tenocytes, adipocytes, smooth muscle cells, and stromal cells of the bone marrow [ 9 ]. (hindawi.com)

This distribution reflects the fact that sickle-cell trait confers a survival advantage against malaria and that selection pressure due to malaria has resulted in high frequencies of the mutant gene especially in areas of high malarial transmission. (who.int)
The sickle-cell gene has become common in Africa because the sickle-cell trait confers some resistance to falciparum malaria during a critical period of early childhood, favouring survival of the host and subsequent transmission of the abnormal haemoglobin gene. (who.int)
There are, however, no firm data on the survival of patients with sickle-cell anaemia on the African continent. (who.int)
Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. (haematologica.org)
Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)

A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)

Hematopoietic stem cell transplantation is the only potentially curative therapy, but it is only an option for select patients. (cancernetwork.com)
Background: Allogeneic hematopoietic stem cell transplantation (alloHCT) is potentially curative but with known negative effects on quality of life. (cdc.gov)

She is currently running a clinical trial examining the effectiveness of administering a double or "tandem" dose of a patient's own healthy stem cells within a relatively short period of time. (cityofhope.org)
Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
The patients enrolled in our trial received a subcutaneous medication for 4 consecutive days to stimulate their bone marrow to produce SCs, their bone marrow was then harvested, SCs were concentrated at the laboratory, and then they were delivered through the patient's cerebrospinal fluid on the fifth day of the procedure. (parentsguidecordblood.org)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
The discovery of low-coverage (i.e. uncovered) regions containing clinically significant variants, especially when they are related to the patient's clinical phenotype, is critical for whole-exome sequencing (WES) based clinical diagnosis. (bvsalud.org)
Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)

Pregnancy and sickle cell anemia (SCA) were diagnosed using standard protocols. (scielo.br)
In the United States, approximately 100,000 people have been diagnosed, whereas in Nigeria, the country with the highest known incidence of SCD, there are approximately 150,000 babies born annually with sickle cell anemia. (newswise.com)

In general, the first decision made in the management of patients with myeloma who require systemic therapy is whether stem cell transplantation is part of the strategy. (medscape.com)

A report of 35 cases of germ cell tumors, half of which were advanced stage or recurrent or progressive disease, demonstrated a 97% sustained remission at 10 months to 54 months after the start of a combination of BEP. (kaiserpermanente.org)

We hypothesized that clinical risk factors could be identified within 2 weeks of onset of severe (stage 3 or 4) acute gut GVHD for identifying a patient population with a very poor outcome. (nature.com)

All patients received high-dose etoposide (60 mg/kg) and allogeneic stem cell transplantation following the TBI. (nature.com)
The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)

Dr Candice Roufosse in Clinical Reader in Renal Pathology at the Centre for Inflammatory Disease, Dept Immunology and inflammation, Faculty of Medicine, Imperial College. (kcl.ac.uk)

Are you an adult with sickle cell disease? (nih.gov)
Are you an adult with sickle cell disease who's recently had a vaso-occlusive episode? (nih.gov)
Not so for the field of reprogrammed embryonic-like stem cells known as induced pluripotent stem cells (iPSCs), which are created by turning the developmental clock back on adult or other specialized cell types through the use of viruses, plasmids, transposons, or other reprogramming factors. (the-scientist.com)

High early mortality rates and a high rate of complications in Wiskott-Aldrich syndrome suggest frequent monitoring by a clinical immunologist is essential. (medscape.com)

At 1 and 6 months after completion of chemotherapy, she presented with anasarca and was diagnosed with relapse exclusively in the bone marrow twice. (karger.com)

ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). (scielo.br)

Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)
The MSCs have been described for the first time as colony forming fibroblasts (CFU-F), a rare population of cells residing in the bone marrow of guinea-pigs or mice [ 1 , 2 ]. (hindawi.com)
Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)
It seems that the term "stem cell" became more popular although the "stemness" was only shown in a more strict sense for MSCs involved in osteogenesis and bone repair. (hindawi.com)
When the biological properties of MSCs were explored in more detail, questions arose whether these cells met the criterion of a true stem cell [ 8 ]. (hindawi.com)
Expansion of MSCs was shown to be limited to a few passages of in vitro culture and the cells underwent replicative senescence [ 11 ]. (hindawi.com)
Therefore, available in vitro protocols for expansion of MSCs do not yield true stem cells. (hindawi.com)
MSCs were also investigated for stem cell qualities in vivo. (hindawi.com)
The current study aimed to investigate the effect of mesenchymal stem cells (MSCs) transplantation as a new strategy for treatment of diabetes in Streptozotacin (STZ) induced diabetic male albino rats. (alliedacademies.org)
After six weeks of MSCs transplantation, the treated group showed a significant amelioration in these biochemical parameters. (alliedacademies.org)

Murdoch DR , Corey GR , Hoen B , Miro JM , Fowler VG Jr , Bayer AS , Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study. (cdc.gov)
There is increasing evidence that malaria not only influences outcome but also changes the manifestations of sickle-cell anaemia in Africa. (who.int)
Low T Cell Numbers Resembling T-B+ SCID in a Patient with Wiskott-Aldrich Syndrome and the Outcome of Two Hematopoietic Stem Cell Transplantations. (medscape.com)

Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
The potential for new treatments fuels both her love for clinical translational research and patient care. (ohsu.edu)
Newswise - CAMBRIDGE, Mass., Nov. 11, 2020 - Intellia Therapeutics, Inc. (NASDAQ:NTLA), announced that it has received a grant from the Bill & Melinda Gates Foundation to research in vivo sickle cell disease (SCD) treatments using its CRISPR/Cas9 genome editing technology. (newswise.com)

p>Our combined expertise allows us to diagnose and treat common, rare and complex bone tumors in children. (nemours.org)
Germ cell tumors of the ovary are uncommon but aggressive tumors, seen most often in young women and adolescent girls. (kaiserpermanente.org)
clinical conditions of the patient, the existence of a tumors are considered rare (KLUSMANN et al. (bvsalud.org)

Anatomy25

Organisms14

Diseases63

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment80

Psychiatry and Psychology2

Phenomena and Processes35

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science4

Named Groups4

Health Care18

Transplant24

Hematopoietic cell8

Trials26

Multiple Myeloma5

Autologous stem cell trans5

Successful bone marrow transpla2

Donor8

Therapies6

Outcomes9

Graft-versus-4

Malignancies6

Hematology1

Stem cell transplantation in pat2

Post-transplantation1

20235

Progenitor12

Found in bone marrow2

Transplants1

Leukemia17

Lymphoma14

Oncology5

20001

Malignant9

Cellular therapy1

HSCT6

Allogeneic blood1

Diseases7

Peripheral blood3

Mononuclear1

Haematopoietic3

Stromal3

Survival6

Cancers1

Potentially curative2

Patient's6

Sickle cell a2

Myeloma1

Remission1

GVHD1

High-dose3

Immunology1

Adult3

Complications1

Relapse1

Abstract1

MSCs10

Outcome3

Treatments3

Tumors3