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  • allogeneic hema
  • 1 In the past 25 years, nearly a thousand patients with these types of storage disorders, including mucopolysaccharidosis (MPS) type I (Hurler syndrome), other MPS, adrenoleukodystrophy (ALD), metachromatic leukodystrophy (MLD), Krabbe disease, and others have received allogeneic hematopoietic stem cell transplantation (HSCT) with bone marrow from matched or mismatched related donors who were either carriers or noncarriers of the disease, resulting in clinical benefit in many of them. (bloodjournal.org)
  • tissue
  • Transplantation consists of a simple injection of few milliliter-purified tissue in the portal vein through a percutaneous trans- hepatic approach performed in local anesthesia. (ingentaconnect.com)
  • Billingham RE and Brent L (1954) Quantitative studies of tissue transplantation immunity. (springer.com)
  • As a result, many researchers have focused on adult stem cells , or stem cells isolated from adult humans that can be transplanted into damaged tissue. (wikipedia.org)
  • Once these MSCs are ready for re-implanation, they are usually transferred with growth factors to allow for continued cell growth and engraftment to the damaged tissue. (wikipedia.org)
  • The National Organ, Tissue and Cell Transplantation Policy is a policy that was formulated by the Surgical and Emergency Services Unit of the Medical Services Development Section, Medical Development Division of the Malaysian Ministry of Health in June 2007. (wikipedia.org)
  • It is also responsible for getting more people to pledge and at the same time act as the registrar for organ, tissue and cells donation in Malaysia. (wikipedia.org)
  • Research into new treatments for spinal cord injuries includes stem cell implantation, engineered materials for tissue support, epidural spinal stimulation, and wearable robotic exoskeletons. (wikipedia.org)
  • The damage can also be divided into primary and secondary injury: the cell death that occurs immediately in the original injury, and biochemical cascades that are initiated by the original insult and cause further tissue damage. (wikipedia.org)
  • An advantage of using teleost fish over other animals, such as pigs, in the studies of diabetes mellitus is that its endocrine cells are separated from the pancreatic exocrine tissue and can be easily isolated and harvested. (wikipedia.org)
  • chronic
  • 1991) Kidney allograft tolerance in primates without chronic immunosuppression-the role of veto cells. (springer.com)
  • Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole. (springer.com)
  • Since there is an enhanced and more durable CD4 cell count recovery when ART is initiated earlier, early HIV treatment may mitigate the downstream effects of chronic inflammation [26, (natap.org)
  • Chronic myelomonocytic leukaemia (CMML) is a type of leukaemia, which are cancers of the blood-forming cells of the bone marrow. (wikipedia.org)
  • Therapy
  • A current definition of gene therapy is the infusion of a therapeutic gene, or cells transduced with the gene, in order to cure or prevent illnesses. (go.jp)
  • The main risk factor for HAdV infection is prolonged immunosuppression, attributable either to in vivo or ex vivo T-cell depletion, prolonged lymphopenia, or to GvHD-associated immunosuppressive posttransplant therapy. (springer.com)
  • mesenchymal stem
  • Recent research demonstrates that articular cartilage may be able to be repaired via percutaneous introduction of mesenchymal stem cells (MSC's). (wikipedia.org)
  • As an example, a PubMed search for the year 1999 reveals about 90 papers published under the MESH heading of "Mesenchymal Stem Cells", the same search ran for the year 2007 reveals more than 4,000 entries. (wikipedia.org)
  • Until recently, the use of cultured mesenchymal stem cells to regenerate cartilage has been primarily in research with animal models. (wikipedia.org)
  • While the use of cultured mesenchymal stem cells has shown promising results, a more recent study using uncultured MSC's has resulted in full thickness, histologically confirmed hyaline cartilage regrowth. (wikipedia.org)
  • organ
  • Many approaches which have proven successful in rodent models of solid organ or cellular transplantation have not translated well to large animals or humans. (springer.com)
  • Its main objective is to spread correct information and increase awareness on organ donation and transplantation in Malaysia. (wikipedia.org)
  • The NTRC also collaborate with various NGOs, religious bodies, students' association, corporate bodies as well as the media to spread information on organ donation and transplantation to the public. (wikipedia.org)
  • Survival
  • The researchers performed in-depth analysis of the effects of labeling on the stem cells, including its effects on cell proliferation, differentiation, survival and electrophysiology. (photonics.com)
  • embryonic stem
  • The majority of research involving genetically modified mammals involves mice with attempts to produce knockout animals in other mammalian species limited by the inability to derive and stably culture embryonic stem cells. (wikipedia.org)
  • Infection
  • Adenoviruses use lactoferrin as a bridge for CAR-independent binding to and infection of epithelial cells. (springer.com)
  • Common applications of BLI include in vivo studies of infection (with bioluminescent pathogens), cancer progression (using a bioluminescent cancer cell line), and reconstitution kinetics (using bioluminescent stem cells). (wikipedia.org)
  • severe
  • There are also occasional settings in which transplantation can be performed without any preparation, primarily in children with severe combined immunodeficiency who lack T cell function [ 1 ]. (uptodate.com)
  • Since more than one type of immune cell is affected, this disease is classified as a severe combined immunodeficiency disease (SCID). (wikipedia.org)
  • consists
  • The immune system consists of specialized cells that work together to fight off bacteria, fungi and viruses. (wikipedia.org)
  • proliferation
  • Granulocyte colony stimulating factor (GCSF) are naturally occurring glycoproteins that stimulate white blood cell proliferation. (wikipedia.org)
  • lesion
  • The knee microfracture surgery technique popularized by Steadman relies on the release of these cells into a cartilage lesion to initiate fibrocartilage repair in osteochondral defects. (wikipedia.org)
  • vivo
  • Because it is noninvasive and offers high spatial resolution, MRI provides an excellent means to track stem cells in vivo - in contrast to invasive modalities, which require the sacrifice of animals at multiple time points. (photonics.com)
  • In the June 12 issue of PNAS , researchers at Stanford University School of Medicine in California reported a study in which they explored the effects of superparamagnetic iron oxide labeling on human central nervous system stem cells grown as neurospheres both in vitro and in vivo. (photonics.com)
  • The use of in vivo T-cell depletion may improve its outcome. (go.jp)
  • Another team used a similar technique for cell extraction and ex vivo expansion but cells were embedded within a collagen gel before being surgically re-implanted. (wikipedia.org)