• It was also demonstrated that USF1 directly binds to the promoter region of 2,492 genes, which may be involved in the viral progression and cell proliferation pathways. (spandidos-publications.com)
  • Quercetin exposure significantly increased γδ T cell proliferation and also raised the expressions of granzyme B (Gra B), perforin (PFP), and interferon- γ (IFN-γ) in γδ T cells. (banglajol.info)
  • To assess the therapeutic potential of naringin and the mechanisms involved, we cultured rat glomerular mesangial cells and grouped them according to different glucose concentrations, different action times, different concentrations of MCC950, and different concentrations of naringin.The cell proliferation was measured by MTT assay. (biomedcentral.com)
  • Naringin also inhibited the proliferation of cells. (biomedcentral.com)
  • Naringin inhibited the proliferation of cells that were induced by high glucose. (biomedcentral.com)
  • Cancer cells mechanosense CAF compression, resulting in an altered localization of the transcriptional regulator YAP and a decrease in proliferation. (bvsalud.org)
  • It interferes with DNA synthesis by blocking methylation of deoxyuridylic acid and inhibiting thymidylate synthetase and, subsequently, cell proliferation. (medscape.com)
  • Influence of quercetin, a flavonoid on the effect of γδ T cells and Wnt/β-catenin signalling pathway in human colon cancer cells (HT55 and HCT116) was investigated. (banglajol.info)
  • The results suggest that quercetin was able to efficiently potentiate the effect of γδ T cells and modulate Wnt/β-catenin signalling pathway. (banglajol.info)
  • However, little is known about the HU NO-related effects on red blood cell (RBC) physiology and NO signalling pathway. (uni-koeln.de)
  • Our study suggests that HU, through its effects on foetal hemoglobin and possibly on NO delivery, would modulate RBC NO signalling pathway, RBC rheology and oxidative stress. (uni-koeln.de)
  • Recent studies suggest that brain cell type specific intracellular environments may play important roles in the generation of structurally different protein aggregates that define neurodegenerative diseases. (biomedcentral.com)
  • Importantly, we discovered that aSYN protein aggregation is modulated by patient brain cells' intracellular milieus at the primary nucleation phase. (biomedcentral.com)
  • However, there is no data that indicates if and how patient-specific brain cells' intracellular milieus modulate protein aggregation. (biomedcentral.com)
  • Here, we studied changes in intracellular environment of PD patients' brain cells and how they modulate aSYN protein aggregation, using human induced pluripotent stem cells (hiPSC) and biochemical methods combined with infrared spectroscopy technique. (biomedcentral.com)
  • Notably, we performed a Thioflavin T (ThT)-based fluorescence assay to examine the effect of patient genome-induced changes in brain cells intracellular milieu on aggregation of recombinant p.A53T aSYN monomers. (biomedcentral.com)
  • We show that the intracellular domain of stem cell marker CD44 (CD44ICD) is released at hypoxia, binds HIF-2α (but not HIF-1α), enhances HIF target gene activation, and is required for hypoxia-induced stemness in glioma. (lu.se)
  • The expression of anti-inflammatory cell signaling molecules, including c-Jun N-terminal kinase (JNK), p38, extracellular signal regulated kinase (ERK), Akt, nuclear factor-κB (NF-κB), inhibitory-κBα (IκBα), iNOS and COX-2, was evaluated by western blot analysis. (spandidos-publications.com)
  • However, there have been no studies on the anti-inflammatory effects of GSP in human hepatic stellate cells (HSCs). (spandidos-publications.com)
  • After liver injury, recruited inflammatory cells accumulate in the damaged site. (spandidos-publications.com)
  • A decline in renal function is related to the accumulation of inflammatory cells in the kidneys, which suggests a causative link. (biomedcentral.com)
  • Different cell types (neutrophils, macrophages, lymphocytes, mast cells and fibroblasts) are responsible for the reconstruction of the extracellular matrix involving growth factors and inflammatory mediators 6 . (scialert.net)
  • CONCLUSION: Repeat organic dust exposure modulated inflammatory mediator production in monocytes independent of endotoxin. (cdc.gov)
  • Hypoxia-inducible factors enhance glioma stemness, and glioma stem cells have an amplified hypoxic response despite residing within a perivascular niche. (lu.se)
  • Published 20 April 2016 Hypoxia modulates global membrane proteome turnover in cancer cells, providing opportunities for tumor specific drug delivery. (lu.se)
  • Using human induced pluripotent stem cells (hiPSC) and biochemical and vibrational spectroscopy techniques, we studied whether Parkinson's disease (PD) patient genomes could modulate alpha-synuclein (aSYN) protein aggregates formation. (biomedcentral.com)
  • However, the role of C1QBP in metabolism, oxidative stress, and apoptosis of renal cell carcinoma (RCC) cells have not yet been explored. (medsci.org)
  • C1QBP knockdown and overexpression cells were established via lentiviral infection and subjected to apoptosis and ROS assay in vitro . (medsci.org)
  • C1QBP promotes the catabolism of hypoxanthine and elevates the apoptosis of RCC cells by modulating XDH-mediated ROS generation. (medsci.org)
  • We presently evaluated the mechanisms by which PTPN2 , a candidate gene for T1D, modulates β-cell apoptosis after exposure to type I and II interferons (IFNs), cytokines that contribute to β-cell loss in early T1D. (diabetesjournals.org)
  • PTPN2 knockdown exacerbated type I IFN-induced apoptosis in INS-1E, primary rat, and human β-cells. (diabetesjournals.org)
  • Of note, both Bim and JNK1 knockdown protected β-cells against IFN-induced apoptosis in PTPN2-silenced cells. (diabetesjournals.org)
  • The present findings suggest that local IFN production may interact with a genetic factor ( PTPN2 ) to induce aberrant proapoptotic activity of the BH3-only protein Bim, resulting in increased β-cell apoptosis via JNK activation and the intrinsic apoptotic pathway. (diabetesjournals.org)
  • Cytotoxic assays have been shown that iHg (5 mu M) caused oxidative stress and intrinsic apoptosis via ROS generation, oxidizing glutathione, damaging DNA, degrading cell membrane integrity, down-regulating mTOR, p-mTOR, akt and ERK1, and up-regulating cleaved caspase 3 and cytochrome c release in PC12 cells 48 h after incubation. (hokudai.ac.jp)
  • Co-treatment of Se (5 mu M) inhibited intrinsic apoptosis and oxidative stress induced by iHg (5 mu M) via inhibiting ROS formation, boosting GPx contents, increasing reduced glutathione, limiting DNA degradation, improving cell membrane integrity, up-regulating mTOR, p-mTOR, akt, ERK1 and caspase 3, and down-regulating cleaved caspase 3 and cytochrome c leakage in PC12 cells. (hokudai.ac.jp)
  • We evaluated whether insulin signaling modulates plasma cell glycoprotein (PC-1) plasma membrane recruitment, posttranslational processing, and gene expression in human cultured cell lines. (unito.it)
  • Chemical compounds that modulate atrial and ventricular cell fate could be used to improve subtype-specific differentiation of endogenous or exogenously delivered progenitor cells in order to promote cardiac regeneration. (biomedcentral.com)
  • Thus, small molecules capable of influencing the fate decisions and differentiation programs of multipotent progenitor cells could facilitate therapeutic regeneration of lost myocardium. (biomedcentral.com)
  • It modulates keratinocyte differentiation. (medscape.com)
  • Background Cytokine-induced killer (CIK) cells can potentially enhance the tumor-killing activity of chemotherapy. (jcancer.org)
  • MicrocircuitDB: Basket cell extrasynaptic inhibition modulates network oscillations (Proddutur et al. (yale.edu)
  • This response was significantly blunted in mice challenged with an irrelevant hapten, or by inhibition of effector cell recruitment, indicating a role for T cell-dependent inflammation in induction of Treg migration. (listlabs.com)
  • The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection. (hindawi.com)
  • Thus, our results indicate that PFOS worsens inflammation-induced intestinal damage with disruption of T-cell homeostasis beyond the gut and provides a novel in vivo toolbox to screen for pollutants affecting intestinal homeostasis. (lu.se)
  • Regulatory T cells (Tregs) are important in controlling skin inflammation, an effect dependent on their ability to home to this organ. (listlabs.com)
  • The NLRP3-inflammasome potentially plays a role in the process of activation and inflammation of glomerular mesangial cells as induced by high-glucose conditions. (biomedcentral.com)
  • Although this predictable pattern of CD8 T-cell responses is well established, the underlying cellular mechanisms regulating the transition to T(M) cells remain undefined. (nih.gov)
  • Altered cellular metabolism is a hallmark of cancer, and much of the published literature has focused on neoplastic cell-autonomous processes for these adaptations. (elifesciences.org)
  • To determine TRPA1 localization in cellular membranes we stained HEK293T cells transfected with the mTRPA1-mCherry construct with the Vybrant Alexa Fluor 488 Lipid Raft Labeling Kit. (elifesciences.org)
  • Telomeres are important component of cell division that protect the genome DNA against cellular senescence and promote chromosomal stability. (springer.com)
  • Similarly, bioactive peptides, which are specific protein fragments that are thought to have physiological health benefits, are good candidates for cosmeceutical components that provide enzyme-modulating activity. (dovepress.com)
  • These gut peptides modulate glucose metabolism by stimulating insulin release after eating and by inhibiting the release of glucagon by pancreatic cells. (medscape.com)
  • Promoter region motif analysis indicated that ETV5 has more binding motifs and genes than USF1 itself for USF1‑regulated DEGs, indicating that USF1 may indirectly modulate gene expression by regulating ETV5 expression in Huh7 cells. (spandidos-publications.com)
  • Type 1 diabetes (T1D) is a chronic autoimmune disease during which pancreatic β-cells are specifically damaged by an aberrant immune response. (diabetesjournals.org)
  • Rosiglitazone and Gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer. (nih.gov)
  • For diabetes induction, rats received alloxan (45 mg kg 1 ) by the intravenous route for pancreatic β cell destruction. (scialert.net)
  • We show that mice with a T-cell-specific deletion of TRAF6 mount robust CD8 T(E)-cell responses, but have a profound defect in their ability to generate T(M) cells that is characterized by the disappearance of antigen-specific cells in the weeks after primary immunization. (nih.gov)
  • This treatment also increased CD8 T(M) cells in wild-type mice, and consequently was able to considerably improve the efficacy of an experimental anti-cancer vaccine. (nih.gov)
  • In addition, diabetic mice presented a reduced influx of TCD4+ cells, TCD8+ cells, B lymphocytes, NK cells, and dendritic cells compared to control infected groups. (hindawi.com)
  • Primary culture of mice skeletal muscle cells (SkMC) was employed as a model for experimental toxoplasmosis studies. (fiocruz.br)
  • We conclude that the timing and intensity of water stress strongly regulate the berry flavonoid accumulation and that proper management of deficit irrigation can modulate the phenylpropanoid and flavonoid pathways. (frontiersin.org)
  • Here we show that tumour necrosis factor (TNF) receptor-associated factor 6 (TRAF6), an adaptor protein in the TNF-receptor and interleukin-1R/Toll-like receptor superfamily, regulates CD8 T(M)-cell development after infection by modulating fatty acid metabolism. (nih.gov)
  • Using a novel approach of co-immunoprecipitation with antibodies to E2 for capture, we identified binding of E2:ERα complexes to FOXP3 protein in CxCa-derived Treg cells. (ncbs.res.in)
  • Calcium modulating ligand (CAMLG or CAML), also known as calcium-modulating cyclophilin ligand, is a signalling protein recognized by the TNF receptor TACI. (wikipedia.org)
  • We characterized the impact of high-dose Rosiglitazone and Gemcitabine therapy on immune suppressive mediators, including MDSC and T regulatory cells, and on modulation of peripheral and intra-tumoral T cell populations. (nih.gov)
  • Rosiglitazone altered tumor-associated immune suppressive mediators by limiting early MDSC accumulation and intra-tumoral T regulatory cells. (nih.gov)
  • At the early stage occurs persistent oxidative damage caused by reactive oxygen species (ROS), mainly produced by mitochondrial of immune cells 7 . (scialert.net)
  • Hematopoietic stem cell transplantation (HSCT) results in the alteration of several components of the immune system. (medscape.com)
  • Immune checkpoints transient third-degree atrioventricular block, and are costimulatory and coinhibitory molecules usually a right hemicorporeal clonic seizure, after which expressed on the surface of immune cells and modu- mental status was persistently altered. (cdc.gov)
  • They occasionally exhibit toxic, mutagenic or carcinogenic effects, or they modulate immune responses. (cdc.gov)
  • however, direct antiproliferative effects against malignant cells and modulation of host immune response may be important. (medscape.com)
  • Insulin treatment restored the leukocyte number in PeLF and restored the presence of B lymphocytes, dendritic cells, and NK cells in lungs of diabetic animals. (hindawi.com)
  • Insulin modulates PC-1 processing and recruitment in cultured human cells. (unito.it)
  • Our study was designed to clarify the involvement of integrins in WNV infection of cells. (nih.gov)
  • We conclude that integrins are involved in WNV infection but not at the level of binding to target cells. (nih.gov)
  • CD8 T cells, which have a crucial role in immunity to infection and cancer, are maintained in constant numbers, but on antigen stimulation undergo a developmental program characterized by distinct phases encompassing the expansion and then contraction of antigen-specific effector (T(E)) populations, followed by the persistence of long-lived memory (T(M)) cells. (nih.gov)
  • In the present study, we aimed to investigate the molecular mechanisms and prophylactic effects of grape seed proanthocyanidin (GSP) on lipopolysaccharide (LPS)-stimulated human hepatic stellate cells (HSCs). (spandidos-publications.com)
  • Mechanisms underlying this modulated response are not clear. (cdc.gov)
  • Once inhaled by the host, the fungus interacts with alveolar macrophages and dendritic cells present in the lungs, where it can form a pulmonary focus or spread through the blood and lymphatic vessels [ 6 ]. (hindawi.com)
  • The CD44ICD was sufficient to induce hypoxic signaling at perivascular oxygen tensions, and blocking CD44 cleavage decreased HIF-2α stabilization in CD44-expressing cells. (lu.se)
  • Our data indicate that the stem cell marker CD44 modulates the hypoxic response of glioma cells and that the pseudo-hypoxic phenotype of stem-like glioma cells is achieved by stabilization of HIF-2α through interaction with CD44, independently of oxygen. (lu.se)
  • Published 14 June 2019 See here how lipid loading may be involved in the paracrine crosstalk between cancer cells and stromal compartment of the hypoxic tumor microenvironment. (lu.se)
  • Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer. (ncbs.res.in)
  • The GH molecule binds to its specific cell surface receptor (GHR), which dimerizes with another GHR molecule so that the single GH molecule is enveloped by 2 GHR molecules. (medscape.com)
  • While alkaloids often exert unique pharmacological effects on animal cells, exposure of sea urchin eggs to nicotine causes polyspermy at fertilization in a dose-dependent manner. (mdpi.com)
  • Reduced β-catenin expression with increased expressions of phosphorylated- β-catenin, axin1 and 2 were observed in HT55 and HCT116 cells on exposure to quercetin. (banglajol.info)
  • RESULTS: Single exposure to organic dust stimulated monocyte secretion of TNF-alpha, IL-6, CXCL8, and IL-10 compared with unstimulated cells. (cdc.gov)
  • We find that CAF-derived exosomes (CDEs) inhibit mitochondrial oxidative phosphorylation, thereby increasing glycolysis and glutamine-dependent reductive carboxylation in cancer cells. (elifesciences.org)
  • We report that ERα ligand oestradiol (E2) is significantly increased in human cervical cancer (CxCa) tissues and tumour-infiltrating Treg cells (CD4+CD25hiCD127low), whereas blocking ERα with the antagonist ICI 182,780 abolishes FOXP3 expression and impairs the function of CxCa infiltrating Treg cells. (ncbs.res.in)
  • Hedgehog ligand-expressing cancerous epithelial cells that are activated by the hedgehog signaling pathway may cause growth-promotion. (medscape.com)
  • Using intra-exosomal metabolomics, we provide compelling evidence that CDEs contain intact metabolites, including amino acids, lipids, and TCA-cycle intermediates that are avidly utilized by cancer cells for central carbon metabolism and promoting tumor growth under nutrient deprivation or nutrient stressed conditions. (elifesciences.org)
  • During tumor progression, cancer-associated fibroblasts (CAFs) accumulate in tumors and produce an excessive extracellular matrix (ECM), forming a capsule that enwraps cancer cells . (bvsalud.org)
  • Our study unveils that the contractile capsule actively compresses cancer cells , modulates their mechanical signaling, and reorganizes tumor morphology. (bvsalud.org)
  • Published 15 August 2016 In this study, we provide new insight into how cancer cells adapt to stress factors present within the tumor microenvironment through increased uptake of lipoproteins. (lu.se)
  • It may increase tumor infiltration by lymphocytes, dendritic cells, and macrophages. (medscape.com)
  • Among the rhythmic firing patterns observed in brain, gamma oscillations, which are involved in memory formation and retrieval, are generated by networks of fast-spiking basket cells (FS-BCs) with robust interconnectivity through fast GABA synapses. (yale.edu)
  • 1 . Proddutur A, Yu J, Elgammal FS, Santhakumar V (2013) Seizure-induced alterations in fast-spiking basket cell GABA currents modulate frequency and coherence of gamma oscillation in network simulations. (yale.edu)
  • Using Arabidopsis thaliana , we show guard cell GABA production is necessary and sufficient to reduce stomatal opening and transpirational water loss, which improves water use efficiency and drought tolerance, via negative regulation of a stomatal guard cell tonoplast-localised anion transporter. (nature.com)
  • Therefore, stomatal guard cells represent an ideal system to test whether GABA signalling occurs in plants. (nature.com)
  • Clear cell RCC (ccRCC) is the most common subtype among the malignant RCCs, accounting for 70-80%, followed by papillary (15%), chromophobe (4-5%), and other fewer subtypes[ 2 ]. (medsci.org)
  • Whereas endothelial cells plated on fibronectin or fibrinogen activate NF-κB in response to flow, cells on collagen or laminin do not. (rupress.org)
  • Combination therapy with Rosiglitazone and Gemcitabine modulated T cell populations by enhancing circulating CD8(+) T cells and intra-tumoral CD4(+) and CD8(+) T cells while limiting T regulatory cells. (nih.gov)
  • Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are generated from oligodendrocyte precursor cells (OPCs) that express neurotransmitter receptors. (nature.com)
  • Conclusion CIK cells can reverse the drug resistance of A549/DDP in a time-dependent manner by reducing GST-π expression to increase the accumulation of DDP. (jcancer.org)
  • In conclusion, TWK10 could be viewed as a potential therapeutic agent that attenuates aging-related disorders and provides health benefits by modulating the imbalance of gut microbiota. (frontiersin.org)
  • Microarray analyses revealed that TRAF6-deficient CD8 T cells exhibit altered expression of genes that regulate fatty acid metabolism. (nih.gov)
  • Oestrogen controls Foxp3 expression in regulatory T cells (Treg cells) via a mechanism thought to involve oestrogen receptor alpha (ERα), but the molecular basis and functional impact of ERα signalling in Treg cells remain unclear. (ncbs.res.in)
  • Together, these data suggest that E2-mediated ERα signalling is critical for the sustenance of FOXP3 expression and Treg cell function in human CxCa via direct interaction of ERα with FOXP3 promoter. (ncbs.res.in)
  • The expression of Interleukin-1β(IL-1β) and Interleukin18 (IL-18) in the cell supernatant were detected by ELISA. (biomedcentral.com)
  • We demonstrate that exosomes secreted by patient-derived CAFs can strikingly reprogram the metabolic machinery following their uptake by cancer cells. (elifesciences.org)
  • The expressions of NLRP3, ASC, caspase-1, IL-1β, and IL-18 in rat glomerular mesangial cells were significantly higher in the high glucose (HG) group than in the control normal glucose (NG) group and exhibited time-dependence activity. (biomedcentral.com)
  • Still, little is known about differential HIF regulation in stem versus bulk glioma cells. (lu.se)
  • Consistent with this, activated CD8 T cells lacking TRAF6 display defective AMP-activated kinase activation and mitochondrial fatty acid oxidation (FAO) in response to growth factor withdrawal. (nih.gov)
  • Our results demonstrate that OPCs are directly modulated by norepinephrine in vivo to enhance Ca 2+ dynamics and promote population homeostasis. (nature.com)
  • Les numérations plaquettaire et leucocytaire ainsi que la concentration en cytokines (IL-2R, IL-8 et TNF-) ont été me- surées. (who.int)
  • Combining genetic and physical manipulations in vivo with microfabrication and force measurements in vitro , we found that the CAFs capsule is not a passive barrier but instead actively compresses cancer cells using actomyosin contractility. (bvsalud.org)
  • Transplantation can result in granulocytopenia as well as impairment of barrier defenses, cell-mediated immunity, and humoral immunity. (medscape.com)
  • Vitamin D may modulate various metabolic processes and may influence cardiometabolic disease risk in Canadians. (cdc.gov)
  • Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
  • 2001. Subchronic dermal application of N,N-diethyl m-toluamide (DEET) and permethrin to adult rats, alone or in combination, causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and purkinje neuron loss in the cerebellum. (cdc.gov)
  • Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
  • The stem cell source may be bone marrow, peripheral blood, or umbilical cord blood. (medscape.com)
  • Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction. (bvsalud.org)
  • Overall, our work gives a molecular insight into ERα signalling and highlights a fundamental role of E2 in controlling human Treg cell physiology. (ncbs.res.in)
  • Through 13C-labeled isotope labeling experiments we elucidate that exosomes supply amino acids to nutrient-deprived cancer cells in a mechanism similar to macropinocytosis, albeit without the previously described dependence on oncogenic-Kras signaling. (elifesciences.org)
  • The reciprocal relationship between HSCs and precancerous hepatocytes or hepatoma cells promotes tumorigenesis, migration and invasion of cancer cells, and formation of metastasis ( 11 ). (spandidos-publications.com)
  • The effect of CIK cells on re-sensitizing lung cancer cells to the chemotherapy drug was partially dependent on the secretion of IFN-γ. (jcancer.org)
  • By mapping CAF force patterns in 3D, we show that compression is a CAF-intrinsic property independent of cancer cell growth . (bvsalud.org)
  • Potential roles of folate and other B vitamins in modulating the risk for diseases (e.g., heart disease, cancer, and cognitive impairment) are under investigation. (cdc.gov)
  • breast cancer cells by competitively binding to and blocking and the NIH Medical Scientist Training Program (L.H. Saal). (lu.se)
  • Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. (biomedcentral.com)
  • Treg, regulatory T cell. (cdc.gov)
  • Simultaneous examination of the migration of CD4 effector cells and Tregs in the same region of uninflamed skin demonstrated that effector cells behaved differently, being uniformly highly migratory. (listlabs.com)
  • Berry flavonoids are differently modulated by timing and intensities of water deficit in Vitis vinifera L. cv. (frontiersin.org)
  • 2001. -Tocopherol modulates liver toxicity of the pyrethroid cypermethrin. (cdc.gov)
  • Hydroxyurea (HU) has been suggested to act as a nitric oxide (NO) donor in sickle cell anemia (SCA). (uni-koeln.de)
  • The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. (medscape.com)
  • The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. (wikipedia.org)