Cell survival tissue survival. Medical search. Frequent questions

We have conducted extensive in vitro studies to confirm its efficacy in supporting stem cell viability, proliferation and new tissue deposition. (ca.gov)
These scaffolds combine the injectability and cell encapsulation of conventional hydrogels with macroporosity, which facilitates nutrient transfer, cell survival, proliferation, and tissue formation. (ca.gov)
Forty-four hours after treatment, a colorimetric proliferation assay was used to measure viable cells in each treated well according to the protocol of Promega (Madison, WI). (cdc.gov)
We discovered that myocilin increased cell proliferation and survival. (nih.gov)
Dr Fan's research interest centres on understanding how cell death, cell proliferation and cell differentiation are coordinated to maintain tissue homeostasis. (birmingham.ac.uk)
He subsequently worked at the University of Texas MD Anderson Cancer Center and the University of Massachusetts Medical School in the United States during which time his research focused on regulation of program cell death (apoptosis) and its related compensatory cell proliferation. (birmingham.ac.uk)
In multicellular organisms, tissue homeostasis requires coordinated cell death, cell proliferation and cell differentiation. (birmingham.ac.uk)
Work by us and others has revealed that, surprisingly, stress-induced apoptotic cells can actively induce proliferation of their neighbouring cells to compensate for the cell loss. (birmingham.ac.uk)
This evolutionarily conserved phenomenon has been termed apoptosis-induced compensatory cell proliferation (apoptosis-induced proliferation or AiP). (birmingham.ac.uk)
We have discovered that apoptosis can induce cell proliferation through distinct mechanisms in a context-dependent manner, e.g. in proliferating versus differentiating tissues ( Fan and Bergmann, Dev Cell 14: 339 ). (birmingham.ac.uk)
miRNA-149 was underexpressed in gastric cancer tissues and cells, while overexpression of miRNA-149 promoted cell apoptosis, retarded cell cycle, and inhibited proliferation and migration in AGS and MKN28 cells. (hindawi.com)
It possesses a unique forkhead domain combined with a fragment of the target gene to initiate transcription [ 10 ] and regulates various biological processes such as tumor cell differentiation, cell proliferation, and migration [ 11 ]. (hindawi.com)
Cell Counting Kit‑8 assay and flow cytometry were undertaken to measure proliferation and apoptosis. (spandidos-publications.com)
shlncRNA XIST attenuated cell proliferation, invasion and migration, while increasing the apoptosis of hepatic carcinoma cells. (spandidos-publications.com)
The miR‑320a mimic and PIK3CA inhibitor could recover the effect of oe‑lncRNA in terms of the proliferation, invasion, migration and apoptosis of hepatic carcinoma cells. (spandidos-publications.com)
Long non-coding (lnc)RNAs play important roles in the development, differentiation, proliferation and apoptosis of cells ( 6 , 7 ). (spandidos-publications.com)
C: Proliferation of AGS and HGC-27 cells assessed by EdU assays. (wjgnet.com)
Lymphangioleiomyomatosis (LAM) is a rare lung disease, resulting from proliferation in the lung, kidney, and axial lymphatics of abnormal smooth muscle-like cells (LAM cells) that exhibit features of neoplasia and neural crest origin. (medscape.com)

SCC of the prostate is a rare malignant epithelial neoplasm arising in the prostate, with squamous differentiation of the neoplastic cells. (medscape.com)
We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)
The pattern of cellular growth has long been known, but it is the Italian developmental biologist Rita Levi-Montalcini and the American biochemist Stanley Cohen with their discovery of nerve growth factor (NGF) and epidermal growth factor (EGF), respectively, who could show how the growth and differentiation of a cell is regulated. (nobelprize.org)
This unique specialization of cells is termed differentiation. (nobelprize.org)
The overall goals of our laboratory are to understand the signaling cues that regulate cell growth, differentiation, and development. (cornell.edu)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repression and transcriptional activation. (lu.se)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)

Importantly, TGM2-v1 silencing caused a marked and significant reduction of MPM cell viability in hypoxic conditions when compared with normoxia. (units.it)
Notably, a TG2-selective irreversible inhibitor that reacts with the intracellular active form of TG2, but not a non-cell-permeable inhibitor, significantly compromised cell viability in MPM spheroids. (units.it)
In the intestine, which is normally more resistant to radiation, the addition of the drug reduced cell viability and survival. (sciencedaily.com)
Methods: This article focuses on recent research development that addresses the viability issues of stem cells. (benthamscience.com)
Results: To increase the viability of stem cells, techniques like scaffolds of stem cells with hydrogel or alginate, pre-conditioning, different routes of administration and encapsulation, are implemented. (benthamscience.com)
E ) Cell viability was analyzed by Trypan blue exclusion assay and is represented as the mean percentage cell survival of 3 independent experiments ( n = 3, mean ± SD). (jci.org)

Exposure to radiation can wreak indiscriminate havoc on cells, tissues, and organs. (sciencedaily.com)
Cells Tissues Organs (2001) 169 (4): 347-354. (karger.com)
Classical definitions of memory T cells derive from the belief that T cells localize and recirculate predominantly throughout the blood and secondary lymphoid organs ( 7 , 8 ). (frontiersin.org)
The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)

Among malignant neoplasms of the penis, squamous cell carcinoma (SCC) is the most common. (medscape.com)
The cause of penile squamous cell carcinoma (SCC) is unclear, although human papillomavirus (HPV) appears to play a major role in many cases. (medscape.com)
Esophageal squamous cell carcinoma affects the squamous cells and usually develops within the middle third of the esophagus. (medicinenet.com)
Squamous cell carcinoma ac- rate for 31 266 patients (74% men, 26% women) with counts for about 4% of cases of bladder cancer, adenocar- urinary bladder cancer diagnosed from 1997 to 2011 was cinoma for about 2% and all other types for about 4% of 72% (10) . (who.int)

2021) Experience with cultured thymus tissue in 105 children. (news-medical.net)

Such tumor-specific T RM cells are recognized as both necessary and sufficient for long-lived protection against tumors in peripheral tissue locations. (frontiersin.org)
Cancer can be considered a disease of immune dysfunction, with a failure of immune recognition leading to the outgrowth of malignant cells as tumors ( 1 ). (frontiersin.org)
Following effective priming in lymph nodes, T cells traffic to tumors and other peripheral tissues. (frontiersin.org)
In a growing number of cases, CD8 T cells have been shown to mediate the regression of large bulky tumors, resulting in durable long-term disease remissions ( 5 ). (frontiersin.org)
HO-1 expression was higher in human primary and metastatic tumors compared with noncancerous tissue. (jci.org)
Patient tumors were molecularly characterized via sequencing of tumor tissue DNA and/or circulating tumor DNA samples. (eurekalert.org)
Incubation of tumor cells with T cell-derived IFNγ and TNFα recapitulated the chemokine profile observed in vivo , confirming the capacity of antitumor CD8 T cells to mediate macrophage infiltration of tumors. (aacrjournals.org)
In this case, CARs include a part specific for the GD2 molecule, which is present at high levels in NB tumors and has already led to promising results in clinical trials of GD2-targeted T cells in NB patients. (texaschildrens.org)
Moreover, tumors which exhibited greater nuclear localization of STAT3 corresponded with patients that presented with lower rates of recurrence-free survival and overall survival. (bvsalud.org)
As with all tumors, whether benign or malignant, the paradigm of comprehension depends on identifying the cell or cell layer of origin. (medscape.com)
Skin malignancies, Merkel cell carcinoma and rare appendageal tumors. (medscape.com)

Meanwhile, we will also start assessing the efficacy of µRB-based scaffolds for supporting stem cell engraftment and bone regeneration in a murine cranial defect model. (ca.gov)
It can be used alone to induce regeneration by stem cells from the body, or in combination with transplanted stem cells. (ca.gov)
Stem cell-based therapies hold great promise for treating tissue loss and enhancing tissue regeneration, often via direct injection of cells at the target site. (ca.gov)
Bach, E.A. JAK/STAT signaling in stem cells and regeneration: From drosophila to vertebrates. (benthamscience.com)
We study genes, proteins and signaling pathways that might be essential for RGC and optic nerve development, function, survival, and regeneration. (nih.gov)
This has important implications for cancer development and tissue regeneration. (birmingham.ac.uk)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)

In a discussion of the paper, David H. Wang, MD, PhD, an associate professor in the Department of Internal Medicine at University of Texas Southwestern Medical Center, Dallas, pointed out that "zolbetuximab is the first molecularly targeted therapy, exclusive of immune checkpoint inhibitors, to demonstrate a statistically significant survival benefit in first-line treatment of advance gastric cancer since trastuzumab. (medscape.com)
qRT-PCR was used to detect the expression of miRNA-149 and FOXC1 in gastric cancer tissues and cells. (hindawi.com)
Human gastric cancer cell lines AGS and MKN28 were cultured and transfected with miR-149 overexpression plasmid and its control or FOXC1 siRNA and its control. (hindawi.com)
In this study, we investigated the inhibitory effects of miR-149 on the biological functions of gastric cancer cells by targeting FOXC1. (hindawi.com)
Twenty pairs of gastric cancer and adjacent nontumor tissues, which were not subjected to radiotherapy or chemotherapy, were obtained from the First Affiliated Hospital of Xi'an Jiaotong University. (hindawi.com)
The human gastric epithelial permanent cell line (GES-1), human gastric cancer cell lines (AGS, BGC-823, MKN45, and SGC-7901), and HEK293 cells were provided by the Biomedical Experiment Center of Xi'an Jiaotong University. (hindawi.com)

Myeloma is a cancer of the plasma cells, the white blood cells that make antibodies that protect against infection. (cdc.gov)
Leukemia is a cancer of the blood cells and bone marrow (the soft, sponge-like tissue in the center of most bones that makes blood cells). (cdc.gov)
Previously, Lahav and colleagues revealed the dynamic behavior of p53 over time and how it affects cancer drug efficacy, cell fate, and more. (sciencedaily.com)
So, the team explored whether manipulating p53 dynamics could increase tumor vulnerability, focusing on human colon cancer cell lines with unmutated, functional p53. (sciencedaily.com)
Shende, P. Role of liposome-based stem cells for multimodal cancer therapy. (benthamscience.com)
It's called triple-negative breast cancer because the cancer cells in TNBC don't have receptors for the hormones estrogen (ER) or progesterone (PR). (cancer.org)
Anti-HER2 drugs are another effective treatment for some types of breast cancer, but they also won't work because the TNBC cells don't have enough HER2 for the drugs to bind to and block the tumor's growth. (cancer.org)
Compared to the microenvironment of other subtypes of breast cancer, the microenvironment around a triple-negative tumor has a large number of immune cells. (cancer.org)
While a great deal of effort has focused on defining their role in immunity to infections, studies now reveal T RM cells as a vital component of the host immune response to cancer. (frontiersin.org)
Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
This review will recount the path to discovering the importance of resident memory CD8 T cells as they pertain to cancer immunity. (frontiersin.org)
The recent success of T cell immune checkpoint inhibitor (ICI) therapies for cancer has revealed CD8 T cells as potent mediators of immunity against advanced cancers ( 4 , 5 ). (frontiersin.org)
As the field of cancer immunotherapy advances rapidly, it is now crucial to understand how the dissemination and maintenance of tumor-specific T cells can be optimally achieved. (frontiersin.org)
These early classifications of T cell memory were quickly brought to bear on the question of what T cell subset provides the best immunity against cancer. (frontiersin.org)
The integrated stress response (ISR) is a critical mediator of cancer cell survival, and targeting the ISR inhibits tumor progression. (jci.org)
When cancer cells develop in the tissues of this muscular tube, it is defined as esophageal cancer . (medicinenet.com)
Esophageal cancer describes the disease where cells that line the esophagus change or mutate and become malignant . (medicinenet.com)
Squamous cells describe thin, flat cells that line the inner surface of the entire esophagus and this type of cancer may occur anywhere in the esophagus, though most are found in the upper half. (medicinenet.com)
This type of cancer arises from the glandular cells found in that area of the esophagus. (medicinenet.com)
There are more rare forms of cancer that affect the esophagus, including lymphoma , malignant melanoma , sarcoma, choriocarcinoma, and small cell cancer. (medicinenet.com)
Esophageal cancer occurs because changes occur in the DNA of cells that line the esophagus. (medicinenet.com)
Squamous cell cancer of the esophagus is related to the use of alcohol and tobacco products, both smoke and smokeless. (medicinenet.com)
In the past, squamous cell cancer was the most common worldwide, but that has changed. (medicinenet.com)
Adenocarcinoma is more common than squamous cell cancer in western countries, including the U.S. The reason for this change has yet to be determined. (medicinenet.com)
This also means there is time and opportunity for the cancer to grow beyond the esophagus and spread ( metastasize ) either to surrounding tissues or to distant parts of the body before it is discovered. (medicinenet.com)
Because of new treatment options, long-term survival and quality of life continue to improve for people diagnosed with this type of cancer. (cancercare.org)
Targeted therapies focus on binding to specific molecules that are important for cancer cell survival and growth. (cancercare.org)
Chemotherapy drugs, given intravenously (through a needle into a vein) or in pill form, can kill cancer cells. (cancercare.org)
Purine analogs are "antimetabolites" that interfere with DNA production and halt the growth of cancer cells. (cancercare.org)
It recognizes and fights against danger, such as infections, viruses and growing cancer cells. (cancercare.org)
A cancer that develops in gland-forming tissue. (ucsfhealth.org)
Anti-cancer drugs used in combination with surgery and/or radiation to destroy residual cancer cells to prevent or delay recurrence. (ucsfhealth.org)
Abnormal amount of DNA in a cell, can correlate with a worse cancer. (ucsfhealth.org)
Cancer invades this membrane and grows into adjacent tissue. (ucsfhealth.org)
The removal of a sample of abnormal tissue that is microscopically examined for cancer cells. (ucsfhealth.org)
In addition to its roles in the regulation of inflammatory diseases and the maintenance of local immune cells, CCL5 expressed by cancer cells plays diverse roles in shaping cancer microenvironments toward their own survival. (nature.com)
Other studies reported that some cancer cells could repress their own CCL5 expression to hinder migration of anticancer immune cells toward cancer sites 15 , 16 . (nature.com)
Therefore, host CCL5 can obviously work as an anticancer molecule to mount relevant immune responses against some cancer cells. (nature.com)
Therefore, it might be safe to say that host CCL5 plays important roles in controlling cancer development but might create either pro- or anticancer environments according to the given situation, such as the type of cells that produce CCL5 and the type of cancers. (nature.com)
CEST) - Patients with metastatic non-small cell lung cancer who received a combined therapy of tremelimumab, durvalumab and chemotherapy experienced longer overall survival compared with those who received chemotherapy alone, regardless of STK11, KEAP1 or KRAS mutational status, according to research from the POSEIDON trial presented at the IASLC World Conference on Lung Cancer 2022 in Vienna. (eurekalert.org)
They did not know, however, the identity of the active substances, just as cancer researchers understood little of the unregulated growth of tumour cells. (nobelprize.org)
This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. (cancerindex.org)
Treatment for extensive stage small cell lung cancer (SCLC) usually involves combination treatment. (healthline.com)
These powerful drugs can stop cancer cells from growing and reproducing. (healthline.com)
That means it seeks out cancer cells wherever they are. (healthline.com)
Cancer cells are masters of disguise. (healthline.com)
It helps it recognize and attack cancer cells. (healthline.com)
Cancer involves rapidly dividing cells. (healthline.com)
The cancer typically begins in a mole, but can also lodge in other pigmented tissues, such as in the eye or in the intestines. (scienceblog.com)
The vaccine includes an oncolytic virus, a reprogrammed virus that has been converted into a cancer-fighting agent that attacks tumor cells while leaving healthy cells undamaged. (scienceblog.com)
Recently, two important areas of emphasis have been to identify and characterize protein-protein interactions that underlie the metabolic changes required for oncogenic transformation and the determination of the roles of non-traditional secretory vesicles (microvesicles, exosomes) in cancer progression and stem cell biology. (cornell.edu)
Hepatoma cell lines (SUN449), hepatoblastoma cell line (HepG2, Huh‑6), liver cancer cell line (HepG2) and transformed human liver epithelial‑2 cells (THLE‑2) were used in the present study. (spandidos-publications.com)
For instance, Deng et al ( 8 ) compared 66 pairs of hepatic carcinoma tissues and normal tissues and found that CCAT1 expression was increased in liver cancer tissues, and that the degree of upregulation was associated with tumor size, vascular invasion and serum alpha-fetoprotein level. (spandidos-publications.com)
This unique therapy involves 'mapping' the prostate cancer cells with a PET scan and then treating them with the Lutetium-177 radioactive substance. (movember.com)
Unlike conventional chemotherapy, PSMA - also known as 'theranostics' - destroys cancer cells, while minimising damage to healthy surrounding tissue. (movember.com)
Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)
In addition, chronic diagnostic test for follow-up of patients cy and for biochemical determination inflammation associated with the infec- with H. pylori gastritis and were able of tissue COX-2 activity using COX tion leads to damage in proteins, the to predict the risk of development of Activity Assay Kit (Cayman Chemical production of reactive oxygen species stomach cancer. (who.int)
No research on survival from bladder cancer at the national level has been conducted before. (who.int)
This study aimed to estimate the probability of survival in patients with bladder cancer in Jordan and identify fac- tors associated with survival. (who.int)
The overall 1-, 3-, 5- and 10-year survival probabilities for urinary bladder cancer were 85%, 73%, 69% and 59%, respectively (standard error = 0.01 for each). (who.int)
The survival of patients with bladder cancer in Jordan is comparable to that reported from developed coun- tries. (who.int)
4.7% of new cases of cancer and 2.8% of all cancer deaths ing in the tissues of the urinary bladder. (who.int)
Survival three main types of bladder cancer: transitional cell car- rates varies significantly among age groups. (who.int)
Urothelial (transitional cell) carcinoma is the most patients younger than 50 years to 81.3% in patients older common histological type of bladder cancer, accounting than 50 years (9) . (who.int)
cancer is the 10th most common cancer in the world, Significant differences in survival rates among age with an estimated 549 393 new cases and 7.2/100 100 groups and treatment types were also found. (who.int)

Mild to moderately abnormal cell when viewed under the microscope, not malignant. (ucsfhealth.org)
Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)

The long-term goal of this grant is to accelerate clinical translation of stem cell-based therapy for regenerative medicine by enhancing cell delivery, survival, and integration, thus improving therapeutic outcomes, substantially reducing the number of cells needed for transplantation, and reducing the associated time and cost to produce these cells. (ca.gov)
Despite the great promise stem cells hold for regenerative medicine, the efficacy of stem cell-based therapies is greatly limited by poor cell engraftment and survival. (ca.gov)
Ramalingam, M. Surface functionalization of nanobiomaterials for application in stem cell culture, tissue engineering, and regenerative medicine. (benthamscience.com)

Background: Stem cells are of two types: embryonic and adult stem cells and they act as a repair system by replenishing body tissue. (benthamscience.com)
Melton, D.A. "Stemness": Transcriptional profiling of embryonic and adult stem cells. (benthamscience.com)
Olfactomedin 1 (Olfm1) and the closely related genes Olfactomedin 2 (Olfm2) and Olfactomedin 3 (Olfm3) show overlapping expression patterns demonstrating preferential expression in the developing and adult neuronal tissues. (nih.gov)
The mechanisms that regulate the ability of epithelia to maintain their integrity in contexts involving large numbers of eliminated cells remain poorly understood, despite the fact that this situation occurs regularly during embryogenesis or the maintenance of adult tissues. (pasteur.fr)
For example, more than ten billion cells can be eliminated every day in an adult intestine. (pasteur.fr)
Adult man consists of billions of cells. (nobelprize.org)
Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)
Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus. (lu.se)

Moreover, HO-1 expression correlated with reduced overall survival of patients with lung adenocarcinoma and glioblastoma. (jci.org)
This is one of the longest median overall survival outcomes for patients with locally advanced mG/GEJ adenocarcinoma in phase 3 trials, Shitera emphasized. (medscape.com)
Barrett's esophagus describes abnormal dysplasia and is thought to perhaps be a precursor to the development of further cell mutations and adenocarcinoma. (medicinenet.com)

However, the majority of transplanted cells die shortly after transplantation, which greatly diminishes the efficacy of stem cell-based therapies. (ca.gov)
We are interested in investigating the potential neuroprotective benefits of stem cell transplantation, which has produced encouraging results in different models of CNS degeneration. (nih.gov)
In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
Outcomes of corneal transplantation in Europe: report by the European Cornea and Cell Transplantation Registry. (who.int)
Thus, the availability of and access to human tissues for transplantation remains essential. (who.int)
Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)
Lung transplantation remains the only potential curative option at end-stage disease but is severely limited by a lack of suitable donor lungs and low long-term survival. (lu.se)
Bioengineering lung tissue or bioengineering cells with biomaterials for transplantation is an exciting new approach to (re)generate tissue to close this large unmet clinical need. (lu.se)
Cell Transplantation. (lu.se)
Treatment includes supportive measures and, if severe, thymus or stem cell transplantation. (msdmanuals.com)

It represents a unique target in that it is restricted to differentiated stomach cells only, and LDN18.2 is absent from all other healthy tissues. (medscape.com)
Targeted therapy treatments are meant to spare healthy tissues and cause fewer side effects than chemotherapy. (cancercare.org)

Used in the frontline setting, zolbetuximab (under development by Ganymed Pharmaceuticals AG) combined with chemotherapy led to significantly longer progression-free survival and overall survival compared to what was seen with chemotherapy alone. (medscape.com)
In previously reported results of the phase 3 POSEIDON trial, patients with EGFR/ALK wild-type metastatic NSCLC who were given first-line tremelimumab, durvalumab and chemotherapy demonstrated statistically significant improvements in both progression-free survival and overall survival versus chemotherapy alone. (eurekalert.org)
Progression free survival and overall survival outcomes were analyzed in patients with (m) or without functional mutations in KRAS, STK11 or KEAP1. (eurekalert.org)

Hematologic cancers begin in the cells of the immune system or in blood-forming tissue, such as the bone marrow. (cdc.gov)
An investigational treatment pioneered by a Duke Health pediatrician resulted in a one-year survival rate of 77% among children born with a rare condition in which they lack an immune system. (news-medical.net)
These nearby immune cells seem to help the tumor grow and become resistant to drugs. (cancer.org)
The presence of immune cells in the microenvironment suggests that immunotherapy may be effective against TNBC. (cancer.org)
Tumor development has been said to occur in three distinct steps: inefficient elimination of early transformed cells, development of a state of equilibrium between tumor cells and immune cells, and tumor escape from immune pressure ( 2 ). (frontiersin.org)
While innate immune cells are important for early tumor immune surveillance, T cells are fundamentally recognized for their crucial role in the antigen-specific recognition and elimination of malignantly transformed cells ( 2 ). (frontiersin.org)
CCL5 is a unique chemokine with distinct stage and cell-type specificities for regulating inflammation, but how these specificities are achieved and how CCL5 modulates immune responses is not well understood. (nature.com)
and chemotherapy causes tumor cell death and antigen release, potentially priming the immune response. (eurekalert.org)

Despite extensive studies by many laboratories for over 15 years since the discovery of a connection between mutations in MYOC and glaucoma, the physiological functions of myocilin in ocular and non-ocular tissues are poorly understood. (nih.gov)
However, it is also found in structures of the brain that are highly vulnerable to hypoxia-induced cell death, where its association with neuronal survival is poorly understood. (jci.org)

Tissue loss and organ failure represents a substantial socioeconomic burden to the State of California, with increasing medical costs for treating patients suffering from various degenerative disease, trauma and congenital defects. (ca.gov)
Median overall survival was significantly longer for patients who received zolbetuximab in comparison with those who did not (13.2 vs 8.4 months). (medscape.com)
For patients with the highest levels of CLDN18.2, median overall survival was even longer (16.7 vs 9.0 months). (medscape.com)
Use of systemic anticoagulation may improve the chance of survival in patients hospitalized with the COVID-19 virus , a large study from the epicenter of the U.S. outbreak suggests. (the-hospitalist.org)
Among nearly 3,000 patients with COVID-19 admitted to New York City's Mount Sinai Health System beginning in mid-March, median survival increased from 14 days to 21 days with the addition of anticoagulation. (the-hospitalist.org)
The results were particularly striking among sicker patients who required mechanical ventilation, in whom in-hospital mortality fell from 62.7% to 29.1% and median survival jumped from 9 days to 21 days. (the-hospitalist.org)
Additional support for a possible survival benefit was published April 27 and included 449 patients with severe COVID-19 treated with heparin (mostly LMWH) for at least 7 days in Hunan, China. (the-hospitalist.org)
Overall survival hazard ratios favored patients in the tremelimumab, durvalumab and chemotherapy arm versus chemotherapy, irrespective of KRAS, STK11 or KEAP1 mutational status, consistent with results in the intent-to-treat population. (eurekalert.org)
With advancements in research on various surgical and drug treatments, the 5-year survival rate of hepatic carcinoma patients has increased ( 3 ). (spandidos-publications.com)
We are currently enrolling patients on a phase 1 trial , GINAKIT2, to find the highest and safe dose of GD2-CAR NKT cells (GINAKIT cells) for subsequent study of their anti-tumor activity. (texaschildrens.org)
In order to help NKT cells expressing the GD2-CAR (CAR.GD2 NKTs) last longer in patients, we included a mediator known as interleukin-15. (texaschildrens.org)
We hypothesize that CAR.GD2-IL15 NKTs will demonstrate anti-tumor activity in NB patients through a combination of directly killing NB cells and indirectly targeting supportive TAMs. (texaschildrens.org)
L'étude portait sur 20 patients atteints d'un carcinome gastrique, 20 patients souffrant d'une gastrite à H. pylori et 20 personnes en tant que groupe témoin. (who.int)
Fields et al reviewed 500 patients with Merkel cell carcinoma in a single-institution study. (medscape.com)
Better survival was observed in patients with early stage and well differentiated tumours at diagnosis. (who.int)
About 60% patients had lower survival rates. (who.int)

Characterized by cell-surface molecules including CD103, CD69, and CD49a, T RM -like tumor-infiltrating lymphocytes (TILs) can be found in a wide range of human cancers, where they portend improved prognosis. (frontiersin.org)

In the hope of revealing new directions for therapies, the group studies molecular biomarkers identified from tissue and brain imaging that are associated with memory problems related to HIV infection, aging , dementia, mental illness and traumatic brain injury. (hopkinsmedicine.org)
However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)

Fig. 4: Specific combinations of cytokines and corticosterone act together to induce PD-1 expression on NK cells. (nature.com)
H19 was also found to induce p-glycoprotein expression and MDR1-associated drug resistance in hepatic carcinoma cells by regulating the demethylation of the MDR1 promoter ( 11 ). (spandidos-publications.com)

Deletion of the proximal enhancer decreases CCL5 expression and augments the cytotoxic activity of tissue-resident T and NK cells, which coincides with reduced melanoma metastasis in mouse models. (nature.com)
[ 7 ] Animal models suggest that estrogen may promote the metastasis of TSC2-deficient cells to the lungs. (medscape.com)

Barde, Y.A. (1989) Trophic factors and neuronal survival. (karger.com)
Effect of tPA on neuronal survival. (jci.org)

Aifantis, I. Regulation of stem cell function by protein ubiquitylation. (benthamscience.com)
Here we found that the regulation of natural killer (NK) cell function by the glucocorticoid receptor (GR) was required for host survival after infection with mouse cytomegalovirus (MCMV). (nature.com)
Thus, the fine tuning of NK cell functions by the HPA axis preserved tissue integrity without impairing pathogen elimination, which reveals a novel aspect of neuroimmune regulation. (nature.com)
Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells. (nature.com)
Using protein-sensitive fluorescent markers, the research team revealed that when a cell dies, the EGFR-ERK pathway - a cell activation signaling pathway known for its involvement in the regulation of cell survival - is temporarily activated in the neighboring cells. (pasteur.fr)

However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)

The requirements for the successful culture of organoids in vitro differ significantly from those of traditional monolayer cell cultures. (mdpi.com)
The survival rate was significantly lower in the highly expressed lncRNA XIST group. (spandidos-publications.com)
5-year survival decreased significantly from 90.8% in (1) . (who.int)

have reported inhibition of WNV by a relatively high concentration of ribavirin (200 _M) given after infection of human oligodendroglial cells in vitro ( 5 ) . (cdc.gov)
The Company will also have a poster presentation comparing the performance characteristics of liver cells in an in vitro setting between non-diseased and non-alcoholic fatty liver disease ("NAFLD") donors. (globenewswire.com)
In order to support its plan to initiate multiple IND-track programs, the Company is providing access to its ExVive™ in vitro tissue disease modeling platform to facilitate high value drug discovery and development collaborations. (globenewswire.com)

The best-known function of the serine protease tissue-type plasminogen activator (tPA) is as a thrombolytic enzyme. (jci.org)
Tissue plasminogen activator was also used in some ICU cases. (the-hospitalist.org)

which means both copies of the gene in each cell have mutations. (medlineplus.gov)
We use recent advances in CRISPR genome engineering and epigenetic control of gene expression to precisely control cell activity in engineered tissues. (utah.edu)
We are specifically interested in applying these techniques for use in tissue engineering, gene therapy, and immunoengineering to modulate tissue development and intervertebral disc degeneration for the treatment of back pain. (utah.edu)
Bowles, RD. (2017) CRISPR Systems and Their Potential for Cell and Gene Therapy Applications for Musculoskeletal Pathology. (utah.edu)
In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), providing a new powerful means for the classification, prediction of survival, and response to treatment of lymphomas. (lu.se)

G: Levels of epithelial-mesenchymal transition-related proteins (E-cadherin and N-cadherin) in AGS and HGC-27 cells determined using western blotting. (wjgnet.com)

Over a period of time, abnormal cells begin to form (metaplasia) and if the GERD is not treated and inflammation continues, the lining of the esophagus begins to change the way it looks and functions (dysplasia). (medicinenet.com)
Lenalidomide (Revlimid) helps the bone marrow produce healthy blood cells while killing abnormal cells. (cancercare.org)
Cells that are both abnormal (atypical) and increased in number. (ucsfhealth.org)
Therefore a potential benefit pathologically to confirm the presence cells, which leads to abnormal differen- could be expected if we had a feasible or absence of gastritis and/or malignan- tiation of cells [3]. (who.int)

Markert further honed the procedure over the years and the treatment now uses engineered human tissue, which is under FDA review. (news-medical.net)
Moreover, leukocytes appear to be a more reliable source of human tissue for assessing DNA damage and possibly other biochemical changes. (cdc.gov)

Zhang, Y. Integrin β1 increases stem cell survival and cardiac function after myocardial infarction. (benthamscience.com)

Two months after keratoplasty there was no statistically significant difference in central endothelial cell loss between the organ-cultured grafts and those preserved in McCarey-Kaufman medium (9% vs 7% cell loss, respectively). (nih.gov)
By using the Drosophila eye as a model, we have revealed striking dynamics in the apoptotic susceptibilities of different cell types in a developing organ ( Fan and Bergmann, Dev Cell 30: 48 ). (birmingham.ac.uk)
The reintroduction of cells, tissue or organ previously removed from an individual, back into the same individual with continued function after reintroduction. (ucsfhealth.org)
The Nobel Prize in Physiology or Medicine is awarded for discoveries which are of fundamental importance for our understanding of the mechanisms which regulate cell and organ growth. (nobelprize.org)
The scientists in the 1940's and 1950's already knew that the addition of blood or organ extracts to cells in culture resulted in their successful growth. (nobelprize.org)

As previously reported by Medscape Medical News, zolbetuximab improved survival in the phase 2 FAST trial, which was conducted in a similar patient cohort. (medscape.com)

Stem cells differentiate into different types of cells, such as neural, hematopoietic, adipose, etc. and are used for the treatment of various conditions like myocardial infarction, spinal cord injury, Parkinson's disease and diabetes. (benthamscience.com)
Cell death in the axial structures, i.e. spinal cord, notochord and surrounding mesenchyme and somites, was analyzed using light and electron microscopy. (karger.com)
Chu-Wang, I.W., R.W. Oppenheim (1978) Cell death of motoneurons in the chick embryo spinal cord. (karger.com)
( 6 ) reported protection of fetal mouse spinal cord tissues with mouse alpha and beta interferon before inoculation with WNV. (cdc.gov)

Thus, here we propose to validate the efficacy of µRB-like hydrogels with tunable stiffness and macroporosity as cell-delivery matrices that enhance the engraftment and survival of stem cells for both soft and hard tissue reconstruction using relevant animal models in vivo. (ca.gov)
Serum and histopathologic evaluation of the implanted therapeutic tissue showed engraftment, retention and functionality through at least 35 days post-implantation, while also demonstrating the sustained presence of key human liver proteins such as albumin in the animal bloodstream. (globenewswire.com)

When compared to chemotherapy alone, there was significant improvement in overall survival and progression-free survival. (healthline.com)

Discussion: Activation of the PI3K/AKT pathway decreases the concentration of apoptotic factors, while the HIF pathway protects stem cells against the micro-environment of tissue (hypoxia). (benthamscience.com)
Two morphological types of cell death were found: apoptosis which was characterized by round or semilunar nuclear chromatin condensations, condensation and shrinkage of the cytoplasm and formation of apoptotic bodies, and cell death without the morphological features of apoptosis which was characterized by pyknotic nuclear chromatin condensations, vacuolated cytoplasm and the formation of numerous intercellular spaces. (karger.com)
Later, apoptotic death appeared in all the axial structures, with the exception of the notochord, where some dying cells displayed features of secondary necrosis. (karger.com)
Taken at face value, senile cataract is intimately associated with the increased risk of oxidative stress, which levies irrevocable changes in the lenticular proteins that impel the lens epithelial cells to the apoptotic phase. (molvis.org)

We're encouraged that our 3D bioprinted liver tissues continue to show retention and functionality in a range of animal disease models, including Alpha-1-antitrypsin deficiency and HT-1, where there is critical unmet need and a potentially significant impact on patient outcomes because of the dire shortage of liver transplants," said Taylor J. Crouch, CEO, Organovo. (globenewswire.com)
Dr. Solange Peters, Centre Hospitalier Universitaire Vaudois, Lausanne University, Switzerland and colleagues conducted an exploratory analyses of survival outcomes in POSEIDON according to KRAS, STK11 and KEAP1 mutational status. (eurekalert.org)

Oppositely, expression of mutated myocilin sensitizes cells to apoptosis induced by oxidative stress. (nih.gov)

Referring to the poster presentation, Dr. Sharon Presnell, chief scientific officer, Organovo, commented, "As we continue to build our library of healthy and diseased liver tissues and isolated primary cells, we are uncovering key functional and genetic features of cells that correlate with specific donor and disease-state attributes. (globenewswire.com)
In contrast, the phosphorylated forms of STAT3 did not correlate with patient survival. (bvsalud.org)

Excessive proteolytic activity, which relates to an imbalance of the elastase/alpha1-antitrypsin system or metalloprotease (MMPs) and their inhibitors (tissue inhibitors of metalloproteases [TIMPs]), may be important in lung destruction and formation of cysts. (medscape.com)

Cell invasion and migration were detected by Transwell assays. (spandidos-publications.com)

Bowles, RD. (2016) Epigenome Editing Protects Human Adipose Derived Mesenchymal Stem Cells from Inflammatory Cytokines While Maintaining their Therapeutic Properties. (utah.edu)

Zolbetuximab is a monoclonal antibody that targets the cell surface molecule CLDN18.2, which is expressed in normal gastric mucosa cells and is retained in mG/GEJ tumor cells. (medscape.com)
This important molecule promotes NKT cell survival and function within tumor tissues. (texaschildrens.org)

B and E ) Mean reduction in cell survival in hippocampal ( B ) and cortical neurons ( E ) 24 hours after incubation with 0-1 μM tPA under normoxic conditions. (jci.org)

2017) Towards Combining Cell Printing and CRISPR Epigenome Editing for Engineered IVD and Musculoskeletal Tissues, Biomedical Engineering Society Annual Meeting, Podium Presentation, Phoenix, AZ. (utah.edu)
Stem Cells Int, 2017, 5718608. (lu.se)

T cell memory is antigen-specific, and can provide durable host-wide protection. (frontiersin.org)
In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
We therfore engineered NKT cells to express a chimeric antigen receptor (CAR) on their surface so that they directly kill NB tumor cells. (texaschildrens.org)
Clear cell acanthoma usually stains positively for epithelial membrane antigen and negatively for carcinoembryonic antigen. (medscape.com)

Such memory T cells were traditionally defined as being comprised of both central memory (T CM ) and effector memory (T EM ) subsets ( 9 ). (frontiersin.org)
Here, we have shown that activating transcription factor 4 (ATF4), a master transcriptional effector of the ISR, protects transformed cells against anoikis - a specialized form of apoptosis - following matrix detachment and also contributes to tumor metastatic properties. (jci.org)

In preliminary studies, our µRB-based scaffolds markedly enhanced the survival of human stem cells and accelerated bone repair in vivo. (ca.gov)
Early successes demonstrated the potential for the therapy, as bone marrow stem cells navigated to the implanted thymus tissue to develop into T cells. (news-medical.net)
Blood cells are produced in the bone marrow. (ucsfhealth.org)

Treatment usually occurs if symptoms develop, if there is a decrease in the red blood cell count or platelet count, or if there is enlargement of the lymph nodes or spleen. (cancercare.org)

Importantly, treated animals showed an improvement in the median survival rate versus non-treated control animals. (globenewswire.com)

In the next report period, we will focus on measuring the functional improvement by monitoring stem cell survival using BLI and fat volume retention using micro-CT imaging over time. (ca.gov)
Stem Cell Rev. Rep. , 2019 , 16 (1), 103-117. (benthamscience.com)
Stem cell niche. (bvsalud.org)

These glandular cells presumably synthesize and secrete the mature secretion. (wikipedia.org)

In-hospital mortality was 22.5% with anticoagulation and 22.8% without anticoagulation (median survival, 14 days vs. 21 days). (the-hospitalist.org)
Median survival is six months to two years. (scienceblog.com)

Ellipsoid gland cells have an extensively infolded basal plasma membrane, abundant ribosomes and whorls of smooth endoplasmic reticulum. (wikipedia.org)

We demonstrated that cells derived from biphasic MPM express the full-length TG2 variant at higher levels than cells derived from epithelioid MPM and normal mesothelium. (units.it)
Under normal conditions, cells express little to no p53. (sciencedaily.com)
This process is essential for the normal functioning and survival of cells in tissues throughout the body. (medlineplus.gov)
Tissue samples were taken from the cervicothoracic region of normal human conceptuses. (karger.com)
We have demonstrated that CTT can act similarly to normal thymus tissue to produce naïve T cells that can then fight infection. (news-medical.net)
The elimination of groups of neighboring cells is never observed in epithelial tissue in normal conditions, when the EGFR-ERK pathway is not deliberately inhibited, even if a large number of cells are eliminated. (pasteur.fr)

Our research is to investigate the molecular control of cell death and how dying cells communicate with their neighbours to maintain tissue homeostasis. (birmingham.ac.uk)
Deciphering these mechanisms will make substantial contributions to our understanding of the cellular strategies and genetic pathways used to maintain tissue homeostasis in response to apoptosis. (birmingham.ac.uk)
We already knew that this pathway plays a key role in regulating cell survival in epithelial tissue, but we were surprised to observe such protective dynamics between cells, " comments Romain Levayer, Head of the Cell Death and Epithelial Homeostasis Unit at the Institut Pasteur and last author of the study. (pasteur.fr)
explains Léo Valon, a scientist in the Cell Death and Epithelial Homeostasis Unit at the Institut Pasteur and first author of the study. (pasteur.fr)
Recent studies using neutralizing anti-CCL5 antibodies have suggested that the constitutive expression of CCL5 plays a regulatory role in maintaining tissue-resident memory (Trm) T cells in the human vaginal tract 9 and mouse skin 10 , suggesting that constitutive CCL5 expression in noninflamed conditions, hereafter referred to as homeostatic CCL5 expression, might be important for homeostasis of tissue-resident lymphocytes. (nature.com)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)

Anatomy16

Organisms8

Diseases39

Chemicals and Drugs75

Analytical, Diagnostic and Therapeutic Techniques and Equipment64

Phenomena and Processes51

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science9

Named Groups1

Health Care26

Geographicals1

Proliferation18

Differentiation7

Viability6

Organs7

Squamous cell carc4

20211

Tumors11

Regeneration7

Gastric cancer6

Cancer65

Malignant2

Regenerative medicine3

Adult8

Adenocarcinoma3

Transplantation12

Healthy tissues2

Progression-free survival and overall sur3

Immune8

Poorly understood2

Patients16

Cancers1

Therapies2

Induce2

Metastasis2

Neuronal survival2

Regulation5

Tumor cell1

Significantly3

Vitro3

Plasminogen activator2

Gene5

Epithelial-Mesenchyma1

Abnormal4

Human tissue2

Zhang1

Organ5

Cohort1

Spinal cord4

Engraftment2

Chemotherapy alone1

Apoptotic4

Outcomes2

Apoptosis induced1

Correlate2

Inhibitors1

Migration1

Mesenchymal stem1

Molecule2

Neurons1

20172

Antigen4

Effector2

Bone3

Lymph1

Versus1

Stem cell3

Glandular cells1

Median survival2

Membrane1

Normal6

Homeostasis6