Cell SurvivalCell ProliferationSurvival RateApoptosisSignal TransductionCells, CulturedCell Line, TumorDisease-Free SurvivalSurvivalCell DivisionCell DifferentiationSurvival AnalysisTime FactorsGraft SurvivalCell CycleCell LinePhosphorylationMice, Inbred C57BLImmunohistochemistryBlotting, WesternRNA, MessengerProto-Oncogene Proteins c-aktRNA, Small InterferingMice, KnockoutCell MovementReverse Transcriptase Polymerase Chain ReactionProto-Oncogene ProteinsGene Expression Regulation, NeoplasticTumor Cells, CulturedCell DeathPhosphatidylinositol 3-KinasesProtein-Serine-Threonine KinasesAntineoplastic AgentsMice, TransgenicTransfectionGene Expression RegulationBromodeoxyuridineEnzyme ActivationDose-Response Relationship, DrugTreatment OutcomeDown-RegulationUp-RegulationLymphocyte ActivationBreast NeoplasmsRNA InterferenceStem CellsT-LymphocytesGene ExpressionMutationKi-67 AntigenFibroblastsFlow CytometryTranscription FactorsEpithelial CellsEnzyme InhibitorsMice, Inbred BALB CKaplan-Meier EstimateModels, BiologicalDNA-Binding ProteinsProto-Oncogene Proteins c-bcl-2Mice, NudeCell CountMolecular Sequence DataNeoplasmsCell Growth ProcessesDisease Models, AnimalGene Knockdown TechniquesRetrospective StudiesTumor Suppressor Protein p53Lung NeoplasmsCaspase 3In Situ Nick-End LabelingProliferating Cell Nuclear AntigenNeoplasm StagingNF-kappa Bbcl-X ProteinMAP Kinase Signaling SystemMitogen-Activated Protein KinasesExtracellular Signal-Regulated MAP KinasesGene Expression ProfilingCell Transformation, NeoplasticPhenotypeRats, Sprague-DawleyNeoplasm ProteinsTumor Suppressor ProteinsCell AdhesionRecombinant ProteinsB-LymphocytesBase SequenceNuclear ProteinsMembrane ProteinsAdenocarcinomaCell Cycle ProteinsCaspasesPrognosisCyclin D1Neoplasm InvasivenessProportional Hazards ModelsFollow-Up Studiesbcl-Associated Death Protein