• Our approach is to first understand how hESC interact with extracellular matrix materials by analyzing candidate adhesive substrate proteins and integrin receptors that mediate attachment, survival, proliferation and differentiation. (ca.gov)
  • Rap 1 is a member of a group of proteins involved in the regulation of cell proliferation and differentiation. (medscape.com)
  • FGF-2 protein is used to support the maintenance of human embryonic stem cells and proliferation and differentiation of induced pluripotent and mesenchymal stem cells. (xlbiotec.com)
  • These breakthroughs have spotlighted FGF-2's prowess in facilitating both the proliferation and differentiation of these vital stem cells. (xlbiotec.com)
  • It plays a pivotal role in supporting cell maintenance, proliferation, and differentiation, making it a must-have in your research arsenal. (xlbiotec.com)
  • Anderson, L. and Caldwell, M.A. (2007) Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease. (scirp.org)
  • CCN1 also induced Jag1 expression in hepatic stellate cells, whereupon they interacted with hepatic progenitor cells to promote their differentiation into cholangiocytes. (jci.org)
  • The diversification of neural-crest-derived sympathoadrenal (SA) progenitor cells into sympathetic neurons and neuroendocrine adrenal chromaffin cells was thought to be largely understood. (silverchair.com)
  • In-vitro studies with isolated SA progenitor cells had suggested that chromaffin cell differentiation depends crucially on glucocorticoids provided by adrenal cortical cells. (silverchair.com)
  • Intradermal adipocyte progenitor cells are activated toward the end of the telogen phase to proliferate and differentiate into mature adipocytes. (jcadonline.com)
  • Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)
  • The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)
  • Mir-206 is well established for the regulation of cellular processes involving skeletal muscle development, as well as mitochondrial functioning. (wikipedia.org)
  • While miR-206 has a well defined role in breast tumor etiology, miR-206 was recently shown to control mesothelioma progression via the regulation of the Ras signaling pathway These studies add to an increasing body of literature showing how small noncoding regulatory RNAs maintain the normal cellular processes that prevent the tumorigenic process. (wikipedia.org)
  • This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)
  • We find that the normal molecular processes that regulate cellular differentiation, homeostasis, growth, and migration of adult and embryonic melanocytes are corrupted during melanoma tumorigenesis, progression, and metastasis. (bu.edu)
  • LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA 1-6 , to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. (hindawi.com)
  • The outcome of LPA signaling is dependent on cellular context and impacts on biological processes such as wound healing, differentiation, neurogenesis, and survival, to name a few [ 4 ]. (hindawi.com)
  • Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
  • Furthermore, several reviews claim that Blimp1 might regulate varied cellular processes including cell survival or growth. (immune-source.com)
  • Pax6 serves as a regulator in the coordination and pattern formation required for differentiation and proliferation to successfully take place, ensuring that the processes of neurogenesis and oculogenesis are carried out successfully. (biolegend.com)
  • All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. (mdpi.com)
  • Thus, RA signalling deregulation has a major impact, both in development and disease, related in many cases to oncogenic processes. (mdpi.com)
  • Subsequent investigation, elucidated NSP 5a3a's potential involvement in cellular processes such as ribosome biogenesis and rRNA processing by validating NSP 5a3a's novel interaction with B23 and ribonuclear protein hnRNP-L possibly implicating NSP 5a3a's involvement in cellular activities such as RNA metabolism and processing [4]. (oncotarget.com)
  • Cells are potent to go under abnormal growth processes and finally lead to tumor/cancer. (pharmiweb.com)
  • They are involved in various cellular processes, including tissue development, immune responses, and maintenance of tissue integrity. (pharmiweb.com)
  • Ig-superfamily CADMs are involved in a wide range of biological processes and are critical for the development and functioning of various tissues and organs in the body. (pharmiweb.com)
  • In addition, AEG-1 as a key modulator regulates aberrant cellular processes within the central nervous system (CNS), where it is involved in neurological diseases such as Huntington's chorea, migraine and HIV-induced neurological disorders ( 7-9 ). (spandidos-publications.com)
  • Prenatal development encompasses the intricate physiological processes that occur during pregnancy, shaping the growth and maturation of the developing fetus. (fnps-society.org)
  • This feature occurs because a shortage of the ALX4 transcription factor caused by deletion of the gene disrupts several cellular processes and impairs proper bone formation (ossification). (medlineplus.gov)
  • Stem cells are emerging as an important source of material for diseases in regenerative medicine. (benthamscience.com)
  • The study of biology of stem cells is the hallmark of the recent emerging field of regenerative medicine and medical biotechnology. (benthamscience.com)
  • I then moved my laboratory to Stanford University as a Siebel Investigator and Instructor at the Stanford Institute for Stem Cell Biology & Regenerative Medicine. (stanford.edu)
  • Cardiovascular regenerative medicine aims to counter muscle loss post ischaemic disease with the identification of new cellular sources for cardiomyocyte replacement. (ox.ac.uk)
  • TP53 is a tumor suppressor gene that functions in modifying DNA errors and/or inducing apoptosis of damaged cells, and both APC and BECN1 genes are involved in CRC and are of importance in cellular growth and metastasis. (scielo.br)
  • Blimp1 mutant embryos screen apoptosis in multiple cell types also, most the mesenchyme cells notably, which communicate high degrees of Blimp1 (8). (immune-source.com)
  • The tumor suppressor p53 responds to a number of extrinsic and intrinsic tension indicators to result in many mobile applications, including cell-cycle arrest, apoptosis, inhibition of angiogenesis/metastasis, and DNA restoration (13C16). (immune-source.com)
  • STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
  • Subsequent investigation of this isoform revealed its novel interaction with B23 [2], a multifunctional nucleolar protein involved in ribosome biogenesis, rRNA transcription, mitosis, cell growth control, and apoptosis [3]. (oncotarget.com)
  • Over-expressed NSP 5a3a in HN30 cells induced a significant degree of apoptosis, an average of a 10.85 fold increase compared to controls 3 days post-transfection. (oncotarget.com)
  • This effect was more significant then the apoptosis observed between Fadu cells over-expressing NSP 5a3a and its controls. (oncotarget.com)
  • Though, the apoptosis induced in the WI38 control cell line showed an average of a 13.2 fold increase between treated and controls comparable to the HN30 cell line 3 days post-transfection. (oncotarget.com)
  • Generally, the process of apoptosis is a critical and essential cellular function allowing regulated turn-over of cells during embryonic development, differentiation, and in response to disease [ 5 - 6 ]. (oncotarget.com)
  • They can trigger apoptosis, a process of programmed cell death, when a cell becomes irreparably damaged or poses a risk of becoming cancerous. (pharmiweb.com)
  • This new collaboration between Helmholtz Zentrum München and Lilly will focus on the identification, validation and targeting of novel pathways and molecules for triggering endogenous beta cell regeneration. (helmholtz-munich.de)
  • Morphological changes, gene and protein expression analysis, including antibody array, LC/MS, mRNA/miRNA sequencing, reveal that Aplnr signaling promotes mesoderm commitment possibly via EGFR and TGF-beta signaling pathways and enhances migration of cells during mesoderm differentiation. (bvsalud.org)
  • Moreover, Aplnr signaling positively regulates MSCs differentiation from hPSCs and increases MSC characteristics and differentiation capacity by regulating pathways, such as EGFR, TGFß, Wnt, PDGF, and FGF. (bvsalud.org)
  • Our research goals are to discover innovative and effective treatments for melanoma by targeting innate pathways that occur during normal melanocyte development and stem cell maintenance. (bu.edu)
  • Building on the newer pathways for pathogenesis includes the E3 ubiquitin ligase Peli1 as an important regulator of T-cell metabolism and antitumor immunity. (medscape.com)
  • In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Differential dosage-dependent roles of OTX2 in specifying regional identities and neuronal cell types during brain development. (cnr.it)
  • The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. (umbc.edu)
  • A stable AEG‑1‑deficient HT22 neuronal cell line was constructed using CRISPR/Cas9 gene‑editing technology. (spandidos-publications.com)
  • Results from RNA sequencing revealed that AEG‑1 modulated neuronal morphology and development by regulating the expression of numerous genes, such as ubiquitin C, C‑X‑C motif chemokine ligand 1, MMP9, Notch1, neuropilin 1 and ephrin type‑A receptor 4. (spandidos-publications.com)
  • In AST, AEG-1 causes glutamatergic excitotoxicity by downregulating the activity of the excitatory amino acid transporter 2 (EAAT2) promoter, leading to neuronal cell death in glioma-induced neurodegenerative disease ( 10 ). (spandidos-publications.com)
  • Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
  • Direct neuronal conversion of resident glial cells is advantageous since they are ubiquitously distributed brain cells able to self-renew and replenish their number, making them ideal candidates for endogenous repair. (lu.se)
  • Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)
  • Role of Otx2 in Epiblast Stem Cells (EpiSCs): Otx2 stabilizes the primed EpiSC state by suppressing mesendoderm into neural fate switch in cooperation with BMP4 and Fgf2. (cnr.it)
  • Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. (scirp.org)
  • The idea that cellular survival and growth could be maintained outside the body was recognized as possible almost hundred years ago when the German zoologist Wilhelm Roux described a successful experiment where he cultured chick neural crest in warm saline for a few days [ 1 ]. (intechopen.com)
  • ATX is essential for development since Enpp2 −/− is lethal at embryonic day 9.5-10.5, with marked vascular and neural tube defects [ 20 , 21 ]. (hindawi.com)
  • Notch signaling is a cell-cell communication system well known as a master regulator of neural development, but also with important roles in the adult central nervous system. (mdpi.com)
  • In zebrafish, Blimp1 promotes differentiation from the embryonic sluggish muscle tissue lineage (9) and specifies neural crest and sensory neuron progenitors (10). (immune-source.com)
  • Pax-6 acts as a critical gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues. (biolegend.com)
  • Among the superfamily of cell adhesion molecules, in this article, we mainly focus on Ig-Superfamily CADMs: the members of the Immunoglobulin superfamily of cell adhesion molecules, which play diverse roles in immune responses, neural development, and cell signaling. (pharmiweb.com)
  • NCAM is crucial for neural development and plays a role in axon guidance, synapse formation, and neural plasticity. (pharmiweb.com)
  • L1CAM plays a role in neural development, axon guidance, and cell migration. (pharmiweb.com)
  • Adipose tissue is a loose connective tissue composed of cells supported by an intracellular matrix as well as by vascular, lymphatic, and neural networks. (jcadonline.com)
  • Mammalian LH-2, a transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types. (embl.de)
  • We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)
  • These findings we translate in vitro into the culture dish using induced pluripotent human stem cells (hiPSC). (helmholtz-munich.de)
  • A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
  • Surfactant is produced by alveolar type II cells which can be differentiated in vitro from patient specific induced pluripotent stem cell (iPSC)-derived lung organoids. (nature.com)
  • Gene therapy has been utilized successfully to repair or inactivate mutations in animal models of monogenic human diseases 19 as well as human in vitro cells 12 . (nature.com)
  • The NSP 5a3a isoform had been found to be highly expressed in-vitro in particular cancer cell lines while very low to un-detectable levels in normal body tissues [1]. (oncotarget.com)
  • Mouse nuclear transfer embryonic stem cells (NT-ESCs) were first established in 2000, and then proved to be able to differentiate either in vivo or in vitro, and give rise to individual tissues through germ line transmission or tetraploid complementation. (benthamscience.com)
  • To investigate the mechanisms of scrib KD -mediated cell competition, we first asked whether it is mediated by soluble factors, as in other cases of in vitro cell competition 6 , 24 . (nature.com)
  • Notably, as in vitro experiments indicated, TAM-derived HBEGF promoted proliferation and invasion of the pancreatic cancer cell line. (biomedcentral.com)
  • Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
  • In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
  • Influence of organochlorine pesticides on development of mouse embryos in vitro . (cdc.gov)
  • 1998. Influence of organochlorine pesticides on maturation and post-fertilization development of bovine oocytes in vitro . (cdc.gov)
  • Role of Orthopedia (Otp) in proliferation, migration and differentiation of the murine neuroendocrine hypothalamus. (cnr.it)
  • Promotes proliferation, survival, migration and differentiation of endothelial cells. (drugbank.com)
  • Rb homeostasis is also essential for self-renewal and survival of human embryonic stem cells 10 . (biolegend.com)
  • Typically, this complex process which regulates cellular homeostasis is characterized by distinct morphological and biochemical signatures including nuclear condensation, cell shrinkage, formation of apoptotic bodies, cellular blebbing and the externalization of phosphatidylserine [ 5 - 6 ]. (oncotarget.com)
  • The basic purpose of hormesis is maintaining a health condition of homeostasis or better in a cell, organ or entire organism. (anti-agingfirewalls.com)
  • Downregulation in cellular ion homeostasis, including ion channel function and neurotransmitter release, were observed after knocking out AEG‑1 expression. (spandidos-publications.com)
  • Adult stem cells play key roles in homeostasis and tissue repair. (biomed.news)
  • Role of Otx2 in Embryonic Stem Cells (ESCs): Otx2 is an intrinsic determinant required to maintain the ESC metastable state by antagonizing ground state pluripotency and promoting commitment to differentiation. (cnr.it)
  • Embryonic stem cells (ESCs) can grow infinitely and give rise to all types of cells in human body, thus of tremendous therapeutic potentials for a variety of diseases, such as Parkinson's disease, spinal cord injury, and diabetes. (benthamscience.com)
  • Moreover, the combination of gene modification and directed differentiation of ESCs provides perfect tool for disease modelling and drug discovery. (benthamscience.com)
  • What is more, by deriving NT-ESCs from patient cells, the problem of immune rejection may be avoided. (benthamscience.com)
  • In agreement with CCN2 playing a role in brain tumor angiogenesis, immunocytochemistry studies indicated that both glioblastoma tumor cells and proliferating endothelial cells stained positive for CCN2. (neuromics.com)
  • Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. (drugbank.com)
  • MEKK3 plays an essential role in embryonic angiogenesis and early heart development. (umbc.edu)
  • Gene profiling analysis allowed to identify a set of about 50 genes whose expression might account for the proliferative activity of CCN2 in these cells. (neuromics.com)
  • Our strength is the generation genetic mouse and human stem cell models including gene knock out models but also fluorescent reporter lines. (helmholtz-munich.de)
  • Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1). (cnr.it)
  • Role of Otx1 and Otx2 in brain evolution: functional equivalence between the invertebrate Orthodenticle and the murine OTX1 and OTX2 gene products supports a conserved genetic program of brain development between insects and mammals. (cnr.it)
  • The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
  • RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)
  • It is a key regulatory gene of eye and brain development. (biolegend.com)
  • We show that MDCK cells silenced for the polarity gene scribble ( scrib KD ) are hypersensitive to compaction, that interaction with wild-type cells causes their compaction and that crowding is sufficient for scrib KD cell elimination. (nature.com)
  • It has recently been reported that Madin-Darby canine kidney (MDCK) epithelial cells silenced for the polarity gene scribble ( scrib KD cells) are eliminated in the presence of wild-type MDCK cells 23 , while they are viable on their own 23 . (nature.com)
  • However, analysis of mice lacking the glucocorticoid receptor gene had revealed that adrenal chromaffin cells develop mostly normally in these mice. (silverchair.com)
  • Astrocyte elevated gene‑1 (AEG‑1) is a key regulatory factor of progression in multiple types of tumor and neurodegenerative disease development. (spandidos-publications.com)
  • Astrocyte elevated gene-1 (AEG-1), which is also known as metadherin and lysine-rich carcinoembryonic antigen-related cell adhesion molecule 1 co-isolated, was first observed to be upregulated in brain astrocytes from patients with HIV-induced Alzheimer's disease ( 1 ). (spandidos-publications.com)
  • Epigenetics is an emerging field within prenatal development research that explores how gene expression can be influenced by environmental factors without altering the underlying DNA sequence. (fnps-society.org)
  • a beta-cell-specific transcriptional enhancer found in the insulin gene. (embl.de)
  • As a result, the protein cannot bind to DNA and regulate gene function, which leads to poorly controlled cell proliferation and migration during development. (medlineplus.gov)
  • An elevated expression of CCN2 has also been detected by Northern blotting in human invasive mammary ductal carcinomas, dermatofibromas, pyogenic granuloma, endothelial cells of angiolipomas and angioleiomyomas, and in pancreatic tumors. (neuromics.com)
  • Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. (drugbank.com)
  • They facilitate adhesion between leukocytes and endothelial cells, enabling leukocyte extravasation into tissues during inflammation. (pharmiweb.com)
  • VCAMs are involved in mediating the adhesion of leukocytes to vascular endothelial cells, facilitating the recruitment of immune cells during inflammation. (pharmiweb.com)
  • PECAM-1 is expressed on the surface of platelets and endothelial cells and is involved in cell adhesion and signaling during immune responses. (pharmiweb.com)
  • First using mouse embryonic stem cells (mESCs) then using human induced pluripotent stem (iPSCs) cells Dr. Burtscher and his team generated numerous fluorescent reporter lines. (helmholtz-munich.de)
  • Expression analysis of the human Hox Complex in teratocarcinoma cells (N-tera2/D1) upon treatment with retinoic acid and the definition of temporal colinearity concept. (cnr.it)
  • Transcription factors (nurr1, pitx3 and lmx1a) that promote embryonic mouse or chicken dopaminergic development were employed to determine if they would modulate lineage restriction of these adult human progenitors. (scirp.org)
  • Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)
  • if human embryonic, only NIH approved human embryonic stem cell lines may be used) as a source for making pancreatic islets, and to determine the basic mechanisms underlying beta cell regeneration in the adult as a basis for producing new cellular therapies for diabetes. (nih.gov)
  • The objective of the study is to investigate the role of Wnt signaling in a human chordoma cell line in terms of proliferation, survival, and invasiveness. (bvsalud.org)
  • Therefore, the present study suggests that the Wnt pathway plays a key role in suppressing the proliferation and invasive characteristics of human chordoma cells and has a great potential as a therapeutic target in further clinical studies. (bvsalud.org)
  • Glycogen Synthase Kinase promotes cell survival, growth, and PAX3 levels in human melanoma cells. (bu.edu)
  • We proposed to develop novel, well-defined, synthetic extracellular matrices that support survival and proliferation of human embryonic stem cells. (ca.gov)
  • Finally, we identified a cyclic RGD peptide that supports growth of human embryonic stem cells. (ca.gov)
  • There is a critical need for new technologies to facilitate growth and differentiation of human embryonic stem cells (hESC) using clinically acceptable, animal-free reagents. (ca.gov)
  • Experiments in human cell lines, mice, Drosophila, and Caenorhabditis elegans have shown that endonuclease G (ENDOG) plays a protective role against the development of TSC. (medscape.com)
  • In the present work, we have isolated and characterized the extracellular vesicles from human AD-MSC to investigate their role in the chondroprotective actions of these cells. (karger.com)
  • Here we show the differentiation of patient specific iPSCs derived from a patient with SFTPB deficiency into lung organoids with mesenchymal and epithelial cell populations from both the proximal and distal portions of the human lung. (nature.com)
  • The human body is made up of about 220 different kinds of specialized cells such as nerve cells, muscle cells, fat cells and skin cells. (benthamscience.com)
  • These cells modeled viral infection of human vasculature by Nipah and Hendra viruses, which are extraordinarily deadly (∼57%-59% fatality rate) and require biosafety-level-4 containment. (stanford.edu)
  • Stem cell research is, in part, a quest to understand cellular differentiation, the process by which a human being develops from one fertilized cell into a multicellular organism composed of over 200 different cell types - for example muscle, nerve, blood cell, or kidney. (jcpa.org)
  • Similarly, when the fertilized egg divides from two cells into four cells, each of these four cells has the potential to individually form a human fetus. (jcpa.org)
  • Contrary to popular belief, stem cells are present in the human body throughout life and are found in many adult organs. (jcpa.org)
  • At the heart of cutting-edge stem cell research lies a key player: the fibroblast growth factor, specifically, the human FGF2 protein. (xlbiotec.com)
  • Historically, FGF-2's influence in supporting the maintenance of human embryonic stem cells has made it a sought-after resource in labs across the globe. (xlbiotec.com)
  • Whether you're diving deep into the mysteries of human embryonic stem cells or exploring the vast potential of iPSCs and MSCs, our FGF-2 protein is tailored to bolster your research outcomes. (xlbiotec.com)
  • In the rapidly evolving landscape of stem cell research, Qkine's recombinant human FGF2 protein (154 aa) stands out as a beacon of quality and efficacy. (xlbiotec.com)
  • With its absence, the human body will be functioning without its "brake" of cell proliferation. (pharmiweb.com)
  • Background: Stromal cells are a functionally important component of human carcinomas. (immune-source.com)
  • Although possible, these strategies are often complicated to transfer to human cells due to technical issues (9 ), and only a few successful cases have been described ( 10, 11 ). (lu.se)
  • Here we describe how this system can be used for human embry- onic stem cells. (lu.se)
  • The development of the human blood-CSF-brain barrier. (cdc.gov)
  • The use of olfactory progenitors as a cell-based therapy for Parkinson's disease (PD) would allow harvest without invasive surgery, provide an autologous cell population, eliminate need for immunosuppression and avoid the ethical concerns associated with embryonic tissues. (scirp.org)
  • Depending on the source, stem cells can be classified into two broad categories i.e. embryonic stem cells that are derived from embryos and non-embryonic stem cells that are derived from adult and fetal tissues. (benthamscience.com)
  • This presentation will focus on efforts through the Fred Hutch Genomics and Bioinformatics Shared Resource towards development of a sample-to-answer analysis service for WGS and mRNA profiling from FFPE tissues. (sttrcancer.org)
  • Ig-superfamily CADMs are involved in mediating cell-to-cell adhesion, helping cells stick together and form tissues and organs. (pharmiweb.com)
  • It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)
  • Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
  • Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
  • The evolution of this vascular tissue allowed for an early dominance of these plants on land (first appearing 430 million years ago, during the Silurian period), giving them the ability to transport water and dissolved minerals through specialized strands of elongated cells that run from the plant root to the tips of the leaves . (newworldencyclopedia.org)
  • ATX is also important in adipogenesis since it is upregulated during preadipocyte differentiation to adipocytes and secreted into circulation by the adipose tissue [ 24 ]. (hindawi.com)
  • They can be used to study cellular and metabolic biology without the use of an animal model or fetal tissue. (nature.com)
  • By maintaining the cells in an undifferentiated state, it ensures their potential for a variety of applications, from tissue engineering to disease modeling. (xlbiotec.com)
  • The molecules are found on the cell surface, where they facilitate adhesion to neighboring cells or the extracellular matrix, creating stable cell structures and supporting tissue organization. (pharmiweb.com)
  • They play a vital role in tissue development, maintaining tissue integrity, and organizing complex cellular structures. (pharmiweb.com)
  • The compromised tissue repair program is attributable to the gradual depletion of stem cells and to altered regulatory signals. (biomed.news)
  • However, emerging evidence suggests resident tissue macrophages (RTMs) of embryonic origin as the sources of TAMs. (biomedcentral.com)
  • Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)
  • Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
  • However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
  • These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages 2,3 . (biolegend.com)
  • At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)
  • The CCN genes encode secreted proteins associated with the Extracellular Matrix (ECM) and cell membrane. (neuromics.com)
  • CCN proteins are matricellular proteins which are involved in the regulation of various cellular functions including: proliferation, differentiation, survival, adhesion and migration. (neuromics.com)
  • In vivo dissection of Otx1 and Otx2 roles in brain development by using reciprocal knock-in mouse models: definition of extended functional equivalence between OTX1 and OTX2 proteins and the relevance of the Otx1 and Otx2 differential transcriptional control. (cnr.it)
  • First, we characterized the cell surface receptors for matrix proteins on stem cells and identified specific proteins that will support adhesion and growth of the cells. (ca.gov)
  • Second, using an interdisciplinary approach, we developed a novel method to screen peptides from these proteins for their ability to support adhesion and proliferation of the stem cells. (ca.gov)
  • Based on our characterization of cell surface receptors for matrix proteins on stem cells completed in the first year, we went on to test specific, purified proteins that will support adhesion and growth of the cells. (ca.gov)
  • Our scientists have developed a wide array of stem cell-focused reagents and resources for many applications including flow cytometry , western blotting , ELISAs , and recombinant proteins for cell differentiation. (biolegend.com)
  • In addition, specific proteins or biological substances can be added to these stem cell cultures to transform them in the laboratory into a large variety of specialized cell types, such as nerve, liver, muscle, bone, and blood cells. (jcpa.org)
  • Tumor suppressor genes code for proteins that inhibit cell division and growth, acting as a control mechanism to prevent excessive cell proliferation. (pharmiweb.com)
  • Some tumor suppressor proteins are involved in maintaining cell adhesion, preventing cells from breaking away and spreading to other parts of the body (metastasis). (pharmiweb.com)
  • Cell adhesion molecules are a diverse group of proteins that play a crucial role in mediating cell-to-cell interactions and cell-to-extracellular matrix interactions. (pharmiweb.com)
  • MEKK2 and MEKK3 are mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs or MAP3Ks), proteins that phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. (umbc.edu)
  • Western blot analysis showed that stromal cells of lung tumours were characterised by a statistically considerably lower phrase level of the p16 proteins as likened with that in regular lung stromal cells. (immune-source.com)
  • Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)
  • Y14 is part of the exon-junction complex (EJC), a set of proteins associated with transcript export, localization, and splicing, playing a critical in embryonic development. (medscape.com)
  • Furthermore, they explore beta cell maturation which is closely related to their function. (helmholtz-munich.de)
  • In the specific realm of stem cells, FGF-2's mechanism centers around creating an environment conducive to the cells' growth and maturation. (xlbiotec.com)
  • Unlike sequence-specific transcription factors, epigenetic regulators do not necessarily bind DNA at consensus sequences, but still achieve reproducible target binding in a manner that is cell and maturation-type specific. (frontiersin.org)
  • Specifically, the protein controls the activity of genes that regulate cell growth and division (proliferation), cell maturation and specialization (differentiation), cell movement (migration), and cell survival. (medlineplus.gov)
  • A number of additional miR-206 regulatory modules have been identified, such as the lncRNA HOTAIR mediated up-regulation of Bcl-w through sequestration of miR-206 which in turn enhances cellular proliferation in breast cancer cells. (wikipedia.org)
  • The regulation of these functions ensures that cells start and stop growing at specific times and that they are positioned correctly during development. (medlineplus.gov)
  • We report here that SMN deficiency, induced in the astroglioma cell line U87MG after lentiviral transduction with a shSMN construct, was associated with an increase in the expression of the main components of Notch signaling pathway, namely its ligands, Jagged1 and Delta1, the Notch receptor and its active intracellular form (NICD). (mdpi.com)
  • In addition, we examined whether these substrates will support differentiation of retinal pigmented epithelial cells, an important, clinically relevant cell type that is currently in clinical trials for eye disease. (ca.gov)
  • Lung development is a complicated process that involves the specialization of multiple bronchiolar and alveolar epithelial populations. (nature.com)
  • Alveolar type II (ATII) epithelial cells synthesize, secrete and recycle all components of surfactant and dysfunction in surfactant metabolism can result in a variety of pediatric lung diseases including respiratory distress syndrome and interstitial lung disease 3 . (nature.com)
  • Although many differentiation protocols in the literature have been successful in mimicking lung development from stem cells, there has not been an examination of how a specific mutation impacts the differentiation process including its effects on the early endoderm, as well as the proximal and distal lung epithelial cell populations in the lung organoids. (nature.com)
  • Stem cells are not specialized and the process of their specialization is called differentiation. (benthamscience.com)
  • Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. (drugbank.com)
  • Thus, in addition to molecules, cells use mechanical means to compete. (nature.com)
  • These molecules are essential for embryonic development, wound healing, immune cell recognition, and many other physiological functions. (pharmiweb.com)
  • These cells, surrounding the hair follicles, secrete signaling molecules that control the progression of the hair cycle. (jcadonline.com)
  • Survival is variable on genetic backgrounds. (jax.org)
  • Faculty in our genetics and cell biology group investigate the genetic basis for animal growth, disease resistance, and nutrient efficiency, and the mechanisms underlying nutrient uptake, cellular differentiation, and lipid secretion. (umd.edu)
  • Emergence of LSC is dependent on individual or combined genetic mutations that broadly determine the cellular affiliation of the leukemia, and permit or impose ectopic self-renewal and a restricted differentiation potential into what constitutes the proliferative bulk of the leukemia ( 5 , 6 ). (frontiersin.org)
  • Competing causes of mortali- or all of the animal species tested genetic variation, health status, life ty may prevent the development of experimentally. (who.int)
  • This iPSC line upon pancreatic b-cell differentiation serves for an easy readout, allowing us to determine Alpha and Beta cell fates in live cells at earliest time points during differentiation, sort these populations and analyse their fate, plasticity and the use drugs to influence this fate decisions. (helmholtz-munich.de)
  • Current knowledge of cellular behavior is mainly acquired by studies concerning homogenous populations of cells cultured as monolayers. (intechopen.com)
  • As a stem cell biologist, I aim to understand the mechanisms through which stem cells differentiate into progressively specialized cell types and to harness this knowledge to artificially generate pure populations of desired cell types from stem cells. (stanford.edu)
  • Current differentiation strategies typically generate heterogeneous cell populations unsuitable for basic research or clinical applications. (stanford.edu)
  • Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
  • To track differentiating cell populations, reporter cell lines generated by homologous recombination (knock-in) or via BAC transgenes have been widely used in mouse cells (5-8 ). (lu.se)
  • Isolation of the murine homologs of the otd and ems homeobox containing genes and analysis of their expression during brain development. (cnr.it)
  • Temporal map during gastrulation of the retinoic acid effect on development and patterning of murine brain. (cnr.it)
  • Because of this local degeneration of a relatively small population of dopaminergic neurons in the midbrain, PD has been considered an especially interesting candidate for cell-replacement therapy. (lu.se)
  • First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
  • Infection of iPSCs with lentiviral inserts is a highly efficient process since stem cells grow quickly, remain undifferentiated in specific cell culture conditions and can establish fully infected clones within 2-3 passages. (nature.com)
  • The advent of iPSCs has opened up the possibility to graft patient-specific cells which most likely would circumvent the need for immunosuppression. (lu.se)
  • In vascular plants, the principal generation phase is the large, dominant, nutritionally-independent sporophyte , which is diploid with two sets of chromosomes per cell . (newworldencyclopedia.org)
  • In non-vascular plants, the principal generation phase is often the gametophyte , which is haploid with one set of chromosomes per cell. (newworldencyclopedia.org)
  • Early vascular plants only developed by primary growth , in which the plants grew through cell division of the plant body. (newworldencyclopedia.org)
  • Secondary growth developed early (the Devonian period, 380 million years ago) in the evolution of vascular plants, which allowed for cell division to take place in the active regions of the plant's periphery. (newworldencyclopedia.org)
  • however, a variety of other cell types are found as well, collectively labeled as stromal vascular fraction (SVF). (jcadonline.com)
  • However, the knowledge about the exact role and mechanism of Aplnr signaling during mesoderm and MSCs differentiation is still primitive. (bvsalud.org)
  • The mechanisms of cellular energy sensing and AMPK-mediated mTORC1 inhibition are not fully delineated. (medscape.com)
  • However, the mechanisms by which scrib KD cells are killed by wild-type cells are largely unknown. (nature.com)
  • We therefore took advantage of this recent observation to investigate the mechanisms of cell competition. (nature.com)
  • This study optimized conditions for the differentiation of hONPs towards dopaminergic neurons. (scirp.org)
  • Several neurotrophic factors were detected in the pre-transfected hONPs which have potential roles in the maintenance, survival and proliferation of dopaminergic neurons. (scirp.org)
  • a protein required for the differentiation of the set of six touch receptor neurons in this nematode. (embl.de)
  • This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. (lu.se)
  • We provide detailed protocols for the generation of lentiviral vectors, the transduction of hES-cells, and their differentia- tion into neurons. (lu.se)
  • Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. (drugbank.com)
  • Spinal muscular atrophy (SMA) is a neurodegenerative disease produced by low levels of Survival Motor Neuron (SMN) protein that affects alpha motoneurons in the spinal cord. (mdpi.com)
  • After differentiating the mutant and corrected cells into lung organoids, we show expression of SFTPB mRNA during endodermal and organoid differentiation but the protein product only after organoid differentiation. (nature.com)
  • Rb , or retinoblastoma protein, is a key regulator of the cell cycle, particularly during the transition from the G1 to S phases. (biolegend.com)
  • Within the brain, the protein is involved in the development of specialized cells that process smell. (biolegend.com)
  • Our FGF-2 protein is precisely the tool you need, sculpted for the highest standards of stem cell research. (xlbiotec.com)
  • The Refametinib ending changed necessary protein typically additionally absence regular efficiency but, they constitute neo-epitopes, when provided in the circumstance of MHC elements at the growth cells' surface area. (immune-source.com)
  • a protein required for the asymmetric division of vulval blast cells. (embl.de)
  • Drosophila melanogaster (Fruit fly) protein apterous, required for the normal development of the wing and halter imaginal discs. (embl.de)
  • The ALX4 protein is necessary for normal development of the skull and formation of the head and face, which begins early in fetal development. (medlineplus.gov)
  • In early development, the skull seems to be particularly sensitive to changes in ALX4 protein activity. (medlineplus.gov)
  • We define lncRNAs and highlight their general roles of in normal development and in cancer. (frontiersin.org)
  • Stem cell research endeavors to generate specific subtypes of classically defined "cell types. (stanford.edu)
  • In order to better appreciate the role of stem cell research in reproductive medicine, there is a need to understand the critical biological principles of stem cell research and its potential applications to medicine. (jcpa.org)
  • While there is a great deal published on the potential medical applications of stem cell research to treat or cure diseases such as diabetes, Alzheimer's disease, Parkinson's disease, cancer, and heart disease, much less has been published on the future impact of stem cell research in reproductive medicine. (jcpa.org)
  • In 2009, in a major reversal of U.S. policy, President Obama signed an executive order pledging to "vigorously support" embryonic stem cell research. (jcpa.org)
  • Applying various stress models, they try to understand how beta cell survival and glucose dependent insulin secretion are affected and how they can be restored. (helmholtz-munich.de)
  • We also show the presence of normal lamellar bodies and the secretion of surfactant into the cell culture medium in the organoids of lentiviral infected cells. (nature.com)
  • 1989. Cellular alterations and enhanced induction of cleft palate after coadministration of retinoic acid and TCDD. (cdc.gov)
  • Hamartin and tuberin are thought to act synergistically to regulate cellular growth and differentiation. (medscape.com)
  • It is a heterogeneous disease, cellularly and molecularly, with an overarching theme of ectopic self-renewal and arrested differentiation potential at multiple levels of the hematopoietic tree ( 1 ). (frontiersin.org)
  • Akin to the normal hematopoietic system, leukemias are sustained by a small number of leukemia stem-like cells (LSC), which can be distinct from the normal hematopoietic stem cells (HSC) but also exhibit functional characteristics of self-renewal and (abnormal or hindered) differentiation, and are often quiescent ( 2 - 4 ). (frontiersin.org)
  • To this end we have generated a double fluorescent iPSC reporter line, where the earliest expressed Alpha- and Beta cell specific transcription factors ARX and PAX4 have been fluorescently labeled by Crispr/Cas9 based knock-in strategies. (helmholtz-munich.de)
  • Transcription factor expression and the rate-limiting enzyme in dopamine synthesis tyrosine hydroxylase (TH) were detected in the transfected cells after 4 month-selection with G418, indicating transfected hONPs were stably restricted towards a dopaminergic lineage. (scirp.org)
  • mRNA in unstressed transcription in HCT116 cells. (immune-source.com)
  • Transcription factors have an important role in the ability of a cell to self-renew and also differentiate into most cell types, also known as pluripotency 1 . (biolegend.com)
  • The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
  • Pax6 is a transcription factor present during embryonic development. (biolegend.com)
  • Reverse transcription‑quantitative PCR and western blotting were carried out to analyze the knockdown efficiency of AEG‑1‑deficient HT22 cell line. (spandidos-publications.com)
  • Quantifying the exact expression levels of the mRNA isoforms encoding these myogenic transcription factors is therefore key to understanding how MuSCs switch between cell states. (biomed.news)
  • We demonstrate that mdPCR can give exact molecule counts per cell for mRNA isoforms encoding the myogenic transcription factor Pax3. (biomed.news)
  • Downregulation of CCN2 expression in these cells was associated with a growth arrest at the G1/S transition while over-expression of CCN2 induced a two-fold increase of the number of cells in the G1 phase. (neuromics.com)
  • This surface proved to be efficient at supporting growth of undifferentiated hESC as well as differentiation of useful cell types. (ca.gov)
  • We propose to develop novel, well-defined, synthetic extracellular matrices for growth and differentiation of hESC. (ca.gov)
  • Growth rate (doubling time) profiles showed that scrib KD cells in pure cultures divide, albeit at a reduced rate, to reach a steadily maintained number ( Supplementary Fig. 1d ), whereas under competing conditions, their numbers collapse following initial growth ( Fig. 1a ). (nature.com)
  • Interestingly, we found that the growth rate of scrib KD cells is not affected by conditioned medium from competing cultures ( Fig. 1b and Supplementary Fig. 1c ). (nature.com)
  • The fibroblast growth factor family, with FGF-2 as one of its prime members, has long been identified as a cornerstone in cellular development and regeneration. (xlbiotec.com)
  • Its interaction with cell surface receptors triggers a cascade of intracellular events leading to cell growth, differentiation, and survival. (xlbiotec.com)
  • When evaluating with microsatellite steady tumors, there is normally some proof for Kitty least partialC immunological development control in MSI malignancies, like (I) the thick regional lymphocytic infiltration (Crohn's-like lymphocytic response), (II) the elevated apoptotic growth cell amount, and (3) the low amount of isolated metastases that (4) network marketing leads to an improved general individual success [1]C[3]. (immune-source.com)
  • In the multistep procedure of carcinogenesis, mutations impacting genetics, whose adjustments are beneficial to the growth cell, will be selected positively. (immune-source.com)
  • This remark is certainly a stunning point in favor of a significant Refametinib contribution to growth development control by FSP-specific Testosterone levels cells in vivo , producing those peptides extremely interesting applicants for the advancement of targeted vaccination strategies. (immune-source.com)
  • This abnormal cell growth and movement leads to malformations in the middle of the face, particularly affecting the nose, which leads to openings (clefts) in the nose. (medlineplus.gov)
  • These stem cell reporter lines are being used to understand how beta- or other pancreatic endocrine cell lineage form and how these lineage decisions can be influenced. (helmholtz-munich.de)
  • Deciphering the underlying mechanism of pancreatic endocrine lineage decisions between Alpha and Beta cell fate. (helmholtz-munich.de)
  • proven to recruit the histone methyltransferase G9a towards the promoter of knockout mice shows that Blimp1 can be a crucial determinant from the germ cell lineage (7, 8), which is important for constant repression of homeobox genes that normally accompany standards of primordial germ cells (PGCs) (7). (immune-source.com)
  • To address this challenge, I mapped the cascade of branching lineage choices through which PSCs differentiate into various endodermal and mesodermal cell types. (stanford.edu)
  • miR-206 is studied in C2C12 myoblast cells as this is a widely used model for the study of cellular differentiation of skeletal muscle. (wikipedia.org)
  • While miR-206 is tightly regulated during the embryonic development of skeletal muscle, miR-206 is also regulated by the nuclear steroid hormone receptor 17β-estradiol. (wikipedia.org)
  • Defective muscle regeneration can severely affect re-innervation by motor axons, and neuromuscular junctions (NMJs) development, ultimately leading to skeletal muscle atrophy. (biomed.news)
  • Some have proposed that the association of seemingly disparate skeletal and hematologic abnormalities is related to the simultaneous development of the heart, the radii, and the megakaryocytes at 6-8 weeks' gestation. (medscape.com)
  • Cells had been gathered 48 h after transfection for mRNA evaluation of mRNA amounts by real-time PCR (and intron 3 confirmed above could mediate p53 responsiveness, two tandem copies of the binding site (p53 wtor p53alengthy with plasmids expressing wild-type p53. (immune-source.com)
  • The Institute of Diabetes and Regeneration Research at Helmholtz Zentrum München and the global pharmaceutical company Eli Lilly and Company (Lilly) have entered a new strategic research collaboration in the field of pancreatic beta cell regeneration. (helmholtz-munich.de)
  • This PA is intended to stimulate the application of advances made in developmental biology, stem cell biology, and diabetes to develop new strategies for diabetes therapy, either through cell replacement or regeneration. (nih.gov)
  • A number of embryonic and adult cell models have been explored preclinically and in patient trials, but modest outcome, coupled with issues with impaired graft survival and limited/immature (trans-) differentiation alongside host rejection, has left the door open for more therapeutically efficacious sources of myocardial regeneration. (ox.ac.uk)
  • Mesenchymal stem cells (MSCs) have received great attention as therapeutic tools due to being a safe, ethical, and accessible option with immunomodulatory and controlled differentiation properties. (bvsalud.org)
  • Its role has been further solidified with the rise of induced pluripotent stem cell (iPSC) research and the exploration of mesenchymal stem cells (MSCs). (xlbiotec.com)
  • 6,7 Mesenchymal stem cells (MSCs) have also been isolated from other sources, such as bone marrow, 8 the placenta, 9 muscle, 10 or blood. (jcadonline.com)
  • In the present study, the effect of MSG on cell viability and its effect on expression of APC , BECN1 , and TP53 genes in SW620 and SW480 colon cancer cell lines were studied. (scielo.br)
  • In participating UK research institutions, investigators can publish open access in Genome Research, Genes & Development, RNA, and Learning & Memory without article publication charges and all staff can read the entire renowned Cold Spring Harbor journal collection. (cshlpress.com)
  • Tumor suppressor genes can promote cellular senescence, a state in which cells stop dividing, preventing the replication of damaged DNA. (pharmiweb.com)
  • However, Fleischman and colleagues did not detect mutations in the coding sequence of HOX genes known to affect radial development. (medscape.com)
  • Further evidence supporting the role of miR-206 in tumorigenesis originates from studies showing miR-206 is highly expressed in triple-negative breast tumors that grow independent of 17β-estradiol when compared to estrogen-receptor positive (ERα+), 17β-estradiol sensitive breast cancer cells. (wikipedia.org)
  • A number of cell lines used to elucidate the role of miR-206 in breast cancer include MCF-7, MDA-MB-231, and MDA-MB-468 cell lines. (wikipedia.org)
  • Role of Otx1 in corticogenesis, pituitary functions and sense organs development. (cnr.it)
  • Collectively, these scholarly research indicate that Blimp1 performs an integral role in the mobile differentiation approach. (immune-source.com)
  • Overall, this work demonstrates that mechanical forces can be responsible for the elimination of cells during cell competition and that p53 levels play a key role both in instructing the mechanical loser status and in the execution of mechanical cell competition. (nature.com)
  • Semaphorins are a wide family of extracellular regulatory signals with a multifaceted role in cell-cell communication. (biomed.news)
  • In summary, the Fetal and Neonatal Physiological Society (FNPS) plays a crucial role in advancing our understanding of prenatal development through rigorous scientific inquiry. (fnps-society.org)
  • Due to its fundamental role in heart development, the epicardium emerges as an obvious candidate. (ox.ac.uk)
  • In astrocytomas, CCN2 expression was particularly elevated in high grade tumors, with a marked effect of CCN2 on cell proliferation. (neuromics.com)
  • Most of the tumors represent hamartomas and, in many organs, resemble embryonic cells, suggesting that the defect occurs at an early stage in life. (medscape.com)
  • Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. (jcancer.org)
  • Tumor suppressors are involved in regulating the cell cycle, ensuring that cells only divide when necessary and that the process is tightly controlled. (pharmiweb.com)
  • CellPhoneDB algorithm was applied to infer macrophage-tumor interaction networks, whereas pseudotime trajectory for dissecting cell evolution and dynamics. (biomedcentral.com)
  • Further, we uncovered several ligand-receptor pairs lining tumor cells and macrophages. (biomedcentral.com)
  • Together, our work deciphered a comprehensive single-cell atlas of the macrophage compartment of PDAC and provided novel macrophage-tumor interaction features with potential value in developing targeted immunotherapies and molecular diagnostics for predicting patient outcome. (biomedcentral.com)
  • The long-term goal is to develop new therapies that preserve and/or restore mass and functionality of patient's remaining beta cells during diabetes progression. (helmholtz-munich.de)
  • LPA receptors and autotaxin (ATX), a secreted phosphodiesterase that produces this phospholipid, are overexpressed in many cancers and impact several features of the disease, including cancer-related inflammation, development, and progression. (hindawi.com)
  • Therefore, we hypothesized that CRC cancer stem cell markers (CRCSC) will identify a group of patients at high risk for progression. (jcancer.org)
  • At present, the majority of previous studies have focused on the function of AEG-1 in the development and progression of various malignancies such as gastric cancer, breast cancer and malignant glioma ( 3 , 4 ). (spandidos-publications.com)
  • In MSI+ malignancies, many genetics getting specifically vulnerable to MSI possess been discovered with the modifying development aspect beta receptor II (TGFRII) getting one of the initial. (immune-source.com)
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
  • Our goal is to improve beta cell differentiation and function, provide platforms for disease modeling and drug screening and, as ultimate goal, help to overcome remaining hurdles for stem cell-derived beta cell replacement therapies in diabetic patients. (helmholtz-munich.de)
  • This is an important, unmet need in the field and development of such a substrate would aid in moving stem cell therapies to the clinic. (ca.gov)
  • However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)
  • The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)