• Results of a randomized phase III study of patients with advanced non-small cell lung cancer (NSCLC) showed that the immune checkpoint inhibitor pembrolizumab (Keytruda®) extended the length of time patients lived before their disease worsened (progression-free survival) compared with chemotherapy. (cancer.gov)
  • Patients who received pembrolizumab had longer median progression-free survival than patients who received chemotherapy, 10.3 months versus 6.0 months. (cancer.gov)
  • an improvement in progression-free survival. (cancer.gov)
  • An earlier phase II trial in KRAS-mutant NSCLC had shown significant improvements in progression-free survival and objective response rate in patients treated with selumetinib plus docetaxel compared to docetaxel alone. (medicalnewstoday.com)
  • An independent Data Monitoring Committee (DMC) recommended halting the trial after concluding that Sutent demonstrated greater progression-free survival compared to placebo plus best supportive care in patients with pancreatic islet cell tumors. (medicalnewstoday.com)
  • 25 % CD44+/CD24− were significantly more likely to recur (83 vs. 14 %, p = 0.003) and had shorter median progression-free survival (6 vs. 18 months, p = 0.01). (springer.com)
  • This CD44+/CD24− phenotype correlates to clinical endpoints with increased risk of recurrence and shorter progression-free survival in patients with ovarian cancer. (springer.com)
  • The combination arm also demonstrated median progression-free survival of 15.1 months compared with 11.1 months in the Sutent group, for a 31% reduced risk for progression. (curetoday.com)
  • Patients with primary plasma cell leukemia experienced high rates of response and improved progression-free survival when treated with bortezomib, dexamethasone plus doxorubicin or cyclophosphamide followed by transplantation. (cancernetwork.com)
  • The 12-month progression-free survival was 58%, and 12 patients were still alive at 1 year. (cancernetwork.com)
  • P =.01) were predictors for progression-free survival (PFS). (onclive.com)
  • Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. (elsevier.com)
  • An 8-gene Tfh signature, signifying organized antitumor immunity, robustly predicted survival or preoperative response to chemotherapy. (jci.org)
  • Martin Reck, M.D., Ph.D., of the German Center for Lung Research, Grosshansdorf, and his colleagues randomly assigned 305 patients who had previously untreated advanced NSCLC and expression of PD-L1 on at least half of their tumor cells to receive either 200 mg of pembrolizumab every 3 weeks or platinum-based chemotherapy. (cancer.gov)
  • She noted, however, that the results of another phase III trial , called CheckMate 026, that compared the efficacy of nivolumab (Opdivo®) with platinum-based doublet chemotherapy as a first-line treatment for patients with advanced NSCLC and PD-L1 positive tumors (defined as present in 1% or more of tumor cells), were "surprisingly disappointing. (cancer.gov)
  • In an accompanying editorial in NEJM , Bruce E. Johnson, M.D., of Dana-Farber Cancer Institute, noted that earlier studies showed that previously treated patients who received the checkpoint inhibitors pembrolizumab or nivolumab had a survival advantage over those who were treated with chemotherapy. (cancer.gov)
  • CHICAGO-First-line therapy with nelarabine plus chemotherapy improves disease-free survival (DFS) for children and young adults with newly diagnosed T-cell cancers. (lww.com)
  • Among the next questions to answer, say the researchers, are whether post-hypoxic tumor cells at metastatic sites are more resistant to chemotherapy than other cells and whether targeting these post-hypoxic cells will be beneficial for treating patients with metastatic cancers. (hopkinsmedicine.org)
  • In this study published in the journal Cell Stem Cell , a team led by researchers at Baylor College of Medicine and MD Anderson Cancer Center combined clinical and laboratory studies to show that a gene called PPM1D, whose function in blood production was unknown, can confer blood cells exposed to the chemotherapy agent cisplatin a survival advantage that might favor the development of leukemia years later. (news-medical.net)
  • However, following exposure to cisplatin and some other chemotherapy drugs, the researchers observed that PPM1D mutants dramatically outcompeted normal cells. (news-medical.net)
  • Taking the results all together, our findings suggest that chemotherapy acts as an evolutionary selection pressure that favors the survival of PPM1D mutant cells because they have better fitness than normal cells and 'win' under this specific type of stress,' said Joanne Hsu, a student in the Medical Scientist Training Program (MD/PhD) at Baylor and a member of the Goodell lab. (news-medical.net)
  • So, when a patient receives cisplatin-based chemotherapy, stem cells carrying PPM1D mutations survive better. (news-medical.net)
  • CD44+/CD24− demonstrated significant resistance to all chemotherapy agents used in all cell lines, with a 71-93 % increase in resistance compared with baseline. (springer.com)
  • In conclusion, the CD44+/CD24− phenotype in ovarian cancer cells demonstrate cancer stem cell-like properties of enhanced differentiation, invasion, and resistance to chemotherapy. (springer.com)
  • Rocconi RP, Matthews KS, Kemper MK, Hoskins KE, Barnes MN (2008) Chemotherapy-related myelosuppression as a marker of survival in epithelial ovarian cancer patients. (springer.com)
  • Luo L, Zeng J, Liang B, Zhao Z, Sun L, Cao D, Yang J, Shen K (2011) Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome. (springer.com)
  • Renal cell carcinoma is characterized by susceptibility to both immunotherapeutic and antiangiogenic treatment approaches and resistance to cytotoxic chemotherapy," they wrote. (curetoday.com)
  • In this study, Royer and colleagues tested whether combined standard chemotherapy with autologous stem cell transplantation followed by allogeneic transplantation or maintenance therapy could lengthen survival among these patients. (cancernetwork.com)
  • The regimen, known as myeloablative autologous hematopoietic stem cell transplant (HSCT), includes chemotherapy and total body radiation to destroy the bone marrow followed by transplantation of the person's own blood-forming stem cells to reconstitute the marrow and immune system. (enewspf.com)
  • The procedure began with doctors collecting a participant's blood-forming stem cells, after which the participant received chemotherapy and radiation to eliminate the bone marrow. (enewspf.com)
  • TP53 mutations identify younger mantle cell lymphoma patients who do not benefit from intensive chemotherapy [published online August 17, (onclive.com)
  • Patients undergoing bone marrow transplant or stem cell gene therapy are first prepared, or conditioned, with non-specific, genotoxic chemotherapy alone or in combination with total body irradiation. (businesswire.com)
  • At ASCO, OncoMed reported Phase 1b clinical trial data in NSCLC for 23 advanced-stage patients who received continuous dosing of demcizumab plus standard-of-care chemotherapy, which showed 43 percent (10 of 23) of patients were alive past two years, demonstrating prolonged survival in this subset of patients. (cnbc.com)
  • At that time, survival data for 23 patients who received truncated doses of demcizumab plus chemotherapy were showing a similar trend toward improved survival, but the data were less mature. (cnbc.com)
  • The updated survival data from our Phase 1b clinical trial in first-line advanced stage non-small cell lung cancer reveals impressive long term survival outcomes for the patients treated with truncated dosing demcizumab and chemotherapy," said Jakob Dupont, M.D., Chief Medical Officer. (cnbc.com)
  • In this image of a human breast tumor, a cluster of malignant cells that have become resistant to chemotherapy are shown in red. (ucsd.edu)
  • MIAMI - An analysis of patients with metastatic renal cell carcinoma treated during the targeted therapy era showed those with private insurance survived significantly longer than those with no insurance or government insurance, according to study results presented at International Kidney Cancer Symposium. (healio.com)
  • This survival disparity was more significant [among] patients aged younger than 65 years, suggesting insurance status determined access to metastatic renal cell carcinoma treatment," Yu-Wei Chen, MD, MS, of Cleveland Clinic Taussig Cancer Institute, and colleagues wrote. (healio.com)
  • Treatment costs for metastatic renal cell carcinoma have increased with the development of targeted therapy, and this may affect access to care, according to study background. (healio.com)
  • Chen and colleagues assessed the effect of insurance status on receipt of treatment and survival among patients with metastatic renal cell carcinoma. (healio.com)
  • Researchers used the National Cancer Data Base to identify patients diagnosed with metastatic renal cell carcinoma from 2006 to 2013. (healio.com)
  • The association between insurance status and survival in metastatic renal cell carcinoma in the United States. (healio.com)
  • HealthDay)-Avelumab (BAVENCIO) was approved this week for first-line treatment of advanced renal cell carcinoma (RCC) in combination with axitinib, the U.S. Food and Drug Administration announced. (medicalxpress.com)
  • Renal cell carcinoma is one of the cancers for which the range of promising treatment options has become considerably wider in recent years. (medicalxpress.com)
  • Sutent is currently approved for both advanced renal cell carcinoma (RCC) and second-line gastrointestinal stromal tumor (GIST), based on efficacy and safety data from large, randomized Phase 3 clinical trials. (medicalnewstoday.com)
  • The combination use of Keytruda plus Inlyta significantly improved survival outcomes among patients with previously untreated advanced renal cell carcinoma - the most common type of kidney cancer. (curetoday.com)
  • The combination use of Keytruda (pembrolizumab) plus Inlyta (axitinib) significantly improved survival outcomes among patients with previously untreated advanced renal cell carcinoma (RCC), according to results from the KEYNOTE-426 trial published in The New England Journal of Medicine . (curetoday.com)
  • Despite the approval of several targeted therapies by entities such as the Food and Drug Administration, the European Medicines Agency and the Pharmaceuticals and Medical Devices Agency, the survival rate among patients with metastatic renal cell carcinoma has plateaued. (curetoday.com)
  • HealthDay)-Diabetes mellitus is associated with worse prognosis in terms of progression-free, overall, and cancer-specific survival in patients with renal cell carcinoma treated surgically, according to a study published in the December issue of The Journal of Urology . (medicalxpress.com)
  • Hakmin Lee, from Seoul National University Bundang Hospital in the South Korea, and colleagues examined the correlation between diabetes mellitus and prognosis in patients with renal cell carcinoma who underwent surgical treatment. (medicalxpress.com)
  • Data were reviewed for 3,075 patients with nonmetastatic renal cell carcinoma treated with radical or partial nephrectomy . (medicalxpress.com)
  • The homeodomain transcription factor and human diabetes gene pancreas/duodenum homeobox protein 1 ( Pdx1 ) regulates β-cell survival and endoplasmic reticulum stress susceptibility, in part through direct regulation of activating transcription factor 4 ( Atf4 ). (pnas.org)
  • Cell functionality was demonstrated by retention of an osteogenic response to bone morphogenetic protein-2 in C2C12 cells. (pnas.org)
  • In summary, we uncovered a signalling pathway operating specifically in T-ALL cells in which ORP4L mediates G protein-coupled ligand-induced PLCβ3 activation, resulting in an increase of mitochondrial respiration for cell survival. (nature.com)
  • Like with CAR-T cell therapy, this form of immunotherapy works by blocking the signal between PD-1 (a protein found in both normal and cancer cells) and the PD-L1 protein on mesothelioma cancer cells. (mesothelioma.com)
  • The human T-lymphotropic virus type-1 (HTLV-1), which causes adult T-cell leukemia and lymphoma, produces a protein called p30 that is essential for the retrovirus to establish an infection. (scienceblog.com)
  • Our findings suggest that the p30 viral protein prolongs the survival of host cells through this interaction with ATM and REG-gamma, and the longer a virus-infected cell survives, the better chance the virus has to spread, " says principal investigator Michael Lairmore, DVM, PhD, professor of veterinary biosciences and associate director for shared resources at the OSUCCC - James. (scienceblog.com)
  • The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. (innovations-report.com)
  • This study adds to our previously published work because it implicates the TNF family member protein called BAFF in the 'revved up' B-cell signaling we found in our patients. (eurekalert.org)
  • Protein Kinase CK2 as Regulator of Cell Survival: Implications fo. (ingentaconnect.com)
  • CK2 is a ubiquitous and highly conserved protein serine / threonine kinase that has long been considered to play a role in cell growth and proliferation. (ingentaconnect.com)
  • Based on these trial results, the U.S. Food and Drug Administration (FDA) approved pembrolizumab to treat metastatic NSCLC with PD-L1 protein present on at least half of tumor cells, as determined by an FDA-approved test called the PD-L1 IHC 22C3 pharmDx assay. (cancer.gov)
  • PD-L1 on tumor cells binds to PD-1 protein on immune cells called T cells , suppressing the immune response to the cancer. (cancer.gov)
  • Earlier trials have shown that expression of the protein on at least 50% of tumor cells seems to be a reasonable cutoff, because those patients who had lower proportions of PD-L1-expressing tumor cells in earlier trials showed response rates substantially lower than those who expressed PD-L1 in 50% or more of cells. (cancer.gov)
  • Protein conformation studies by a collaboration of researchers in Japan identify changes in protein shape that contribute to autophagy, a major system for degrading cellular material and maintaining cells. (nanowerk.com)
  • Cells have further adapted autophagy for other purposes as well, including recycling dysfunctional components, immune response to pathogen invasion, surveillance against cancer and maintenance of protein and organelle control in the central nervous system. (ucsd.edu)
  • MTORC1 is a critical protein complex that regulates energy consumption and growth in cells. (ucsd.edu)
  • By degrading cytoplasmic components autophagy releases amino acids for protein synthesis and fatty acids for oxidation in mitochondria to produce energy for survival. (sigmaaldrich.com)
  • or you can do the vitality assay on cells with different numbers than normalize your assay with total protein or nucleic acid contents. (protocol-online.org)
  • Because I used MTT for cell viability, I can not use the exact same well for protein assay. (protocol-online.org)
  • To learn whether GABA is a factor in the newborn neurons' survival and behavior, the research team tagged newborn neurons from mouse brains with a fluorescent protein and then watched their response to GABA. (hopkinsmedicine.org)
  • The researchers noted the benefit found with Keytruda in combination with Inlyta was also observed across risk groups (favorable, intermediate and poor risk) and regardless of PD-L1 expression - a type of protein found on cancer cells that helps to determine treatment options. (curetoday.com)
  • Dr Doug Fairlie (right) and Dr Erinna Lee, from the institute's Structural Biology division, have shown that a pro-survival protein called Bcl-w can adopt a surprising structure. (healthcanal.com)
  • Dr Doug Fairlie , Dr Erinna Lee, and Professor Peter Colman from the institute's Structural Biology division have shown that a pro-survival protein called Bcl-w can adopt a surprising structure unlike that seen in any other Bcl-2 family protein to date. (healthcanal.com)
  • We determined the structure of an unusual form of Bcl-w, a pro-survival protein discovered here at the institute," Dr Fairlie said. (healthcanal.com)
  • I also investigated the repression of the transcription factor c-Jun, by itself and by Krox-20, in immature Schwann cells and found that this occurs mainly at the protein, rather than the transcriptional level. (bl.uk)
  • Tom Burdon and colleagues identify a new variant form of the adaptor protein Gab1 that contributes to LIF-dependent survival of ESCs when nutrient availability is limited. (biologists.org)
  • This paper reports the identification of a new variant form of the adaptor protein Gab1 that is constitutively associated with ESC membranes and supports LIF-dependent survival under conditions of limited nutrient availability. (biologists.org)
  • Radiation mainly works by producing free radicals that reacts with biomolecules (DNA, protein and lipid) in mammalian and other types of cells. (rockland-inc.com)
  • Mcl-1 is an anti-apoptotic protein of the Bcl-2 family that is essential for the survival of multiple cell lineages and that is highly amplified in human cancer. (mdpi.com)
  • Ubiquitination of Mcl-1, that targets it for proteasomal degradation, allows for rapid elimination of the protein and triggering of cell death, in response to various cellular events. (mdpi.com)
  • In unstimulated cells, most of the NF-κB is localized in the cytoplasm in complex with an inhibitory protein, IκB( Baldwin, 1996 ). (rupress.org)
  • Ligation of ITAM-containing receptor complexes results in recruitment and activation of protein tyrosine kinases, which initiate the signaling cascade, resulting in secretion of effector cytokines, such as IFN-γ, and target cell cytotoxicity. (jimmunol.org)
  • We further identify the 3-phosphoinositide-dependent protein kinase 1 (PDK1), a well-known kinase involved in the PI3K-Akt signaling pathway, as a direct Meis3 target, which mediates its role in β-cell survival. (biomedsearch.com)
  • Survival of motor neuron or survival motor neuron (SMN) is a protein that in humans is encoded by the SMN1 and SMN2 genes. (wikipedia.org)
  • In animal models of various cancer types, so-called cancer stem cells (CSCs) have been shown to be important for disease maintenance and therapy resistance. (nature.com)
  • CHICAGO -- Cells shed by a metastatic castration-resistant prostate cancer into the blood may be a robust measure of how well treatment is working, a researcher said here. (medpagetoday.com)
  • Metabolic pathways are reprogrammed in cancer to support cell survival. (nature.com)
  • The low survival rates and the high percentage of patients diagnosed at advanced stages demonstrate that oral and oropharyngeal cancer patients should receive more attention. (hindawi.com)
  • Among several histological types of oral neoplasia, the squamous cell carcinoma (SCC) is the more frequent, representing 90% of all cases of oral cancer [ 2 ]. (hindawi.com)
  • Cancer is primarily a disease caused by genetic changes that progress as sequential series of somatic mutations in specific genes such as protooncogenes and tumor suppressor genes, resulting in uncontrolled cancerous cell proliferation [ 3 , 4 ]. (hindawi.com)
  • Oral and oropharyngeal cancer has a survival rate ≤50% after 5 years. (hindawi.com)
  • Survival statistics for small cell lung cancer are very general estimates and must be interpreted very carefully. (cancer.ca)
  • There are many different ways to measure and report cancer survival statistics. (cancer.ca)
  • Your doctor can explain the statistics for small cell lung cancer and what they mean to you. (cancer.ca)
  • Net survival represents the probability of surviving cancer in the absence of other causes of death. (cancer.ca)
  • Survival varies with each stage of lung cancer. (cancer.ca)
  • Many statistics for small cell lung cancer are reported as median survival. (cancer.ca)
  • Median survival is the length of time after diagnosis or the start of treatment when half of the people with cancer are still alive. (cancer.ca)
  • For example, if 50% of people with a cancer are still alive 12 months after their diagnosis, then the median survival for that cancer is 12 months. (cancer.ca)
  • There are no specific Canadian statistics available for the different stages of small cell lung cancer. (cancer.ca)
  • Limited stage small cell lung cancer has a median survival of 12 to 16 months, with treatment. (cancer.ca)
  • CAR-T cell therapy works by ensuring T cells can still recognize the cancer cells in the body, as many have been able to trick the immune system into thinking they are normal, healthy cells. (mesothelioma.com)
  • CD4 + T cells are critical regulators of immune responses, but their functional role in human breast cancer is relatively unknown. (jci.org)
  • Our identification of CD4 + Tfh cells in breast cancer suggests that they are an important immune element whose presence in the tumor is a prognostic factor. (jci.org)
  • Survival statistics for non-small cell lung cancer are very general estimates and must be interpreted very carefully. (cancer.ca)
  • There are no specific Canadian statistics available for the different stages of non-small cell lung cancer. (cancer.ca)
  • This study collected survival data about lung cancer on more than 81,000 patients from 19 countries, including Canada. (cancer.ca)
  • It may not accurately reflect the advances in treatment for lung cancer that have occurred since targeted therapies and immunotherapy have become a treatment option for non-small cell lung cancer. (cancer.ca)
  • The Canadian Cancer Trials Group is improving glioblastoma survival in the elderly. (cancer.ca)
  • A new research study published in the October issue of Cancer Cell identifies a molecular switch that integrates cell survival signals from multiple intracellular signaling pathways. (innovations-report.com)
  • The finding has substantial clinical significance, as mutations in these cell survival-signaling pathways are associated with many human cancers, and a better understanding of how these pathways converge to regulate the delicate balance between cell proliferation and cell death may lead to development of more effective cancer therapies. (innovations-report.com)
  • Dr. Neal Rosen and colleagues from Memorial Sloan-Kettering Cancer Center in New York examined interplay between cell proliferation signals in tumor cells with PTEN mutations. (innovations-report.com)
  • In a paper published in the journal, Blood , a team from the University of North Carolina's Lineberger Comprehensive Cancer Center, shows in the laboratory that B cells from patients with chronic GVHD are much more active than cells from patients without the disease. (eurekalert.org)
  • We have adapted the pulse-chase expression of H2BeGFP for labeling and isolating slow-cycling cancer cells (SCCCs). (jci.org)
  • 5-Hydroxymethylcytosine (5hmC), generated by TET2 enzymatic activity, labeled the SCCC genome in carcinomas and was a predictive biomarker of relapse and survival in cancer patients. (jci.org)
  • If cell death does not occur when it should, cancer and other diseases may develop. (cshlpress.com)
  • This volume includes discussion of tumor suppression, the altered metabolism of cancer cells, and the development of therapeutic drugs. (cshlpress.com)
  • It is an essential reference for cell and developmental biologists, cancer biologists, and all who want to understand when and how cell death is required for life. (cshlpress.com)
  • The interplay between different forms of cell death have significant implications for the study of cancer and potential treatments, in particular for the toxicity and side-effects of newer anticancer agents, gearing us towards more effective therapeutics in future. (frontiersin.org)
  • The findings by researchers at the Ohio State University Comprehensive Cancer Center are published in the Jan. 15 issue of the journal Developmental Cell, with an accompanying commentary. (innovations-report.com)
  • In the phase III, double-blind, randomized SELECT-1 trial, 510 patients with KRAS-mutant non-small-cell lung cancer were randomized either to oral selumetinib (75mg, twice daily) plus intravenous docetaxel (75mg/m2 on day 1 of a 21 day-cycle), or docetaxel plus placebo . (medicalnewstoday.com)
  • Cancer cells in children tend to develop by following four main trajectories - and two of them are linked to relapse of the disease, research led by Lund University in Sweden shows. (eurekalert.org)
  • The researchers mapped out the genome of cancer cells from more than 50 tumours in order to identify the four strategies. (eurekalert.org)
  • When cancer cells multiply, mutations are formed and thus new types of tumour cells, known as clones, can occur. (eurekalert.org)
  • We wanted to learn more about how some tumours evade treatment and the strategies the cancer cells develop", explains Jenny Karlsson at Lund University, one of the researchers behind the study. (eurekalert.org)
  • Therefore, the researchers mapped out the genome of cancer cells from more than 50 tumours from patients with Wilms tumour, neuroblastoma and rhabdomyosarcoma. (eurekalert.org)
  • It seems that some cancer cells are programmed from the outset to single-handedly create a relapse. (eurekalert.org)
  • If we knew more about how the environment in the patient's tissues triggers cancer cells to develop, we could also influence how they change during treatment and perhaps prevent a relapse. (eurekalert.org)
  • BRUSSELS -- Greater numbers of circulating tumor cells predict worse metastatic breast cancer prognosis without a threshold, researchers reported here. (medpagetoday.com)
  • Explain to interested patients that this study showed that greater numbers of circulating tumor cells predicted a worse metastatic breast cancer prognosis. (medpagetoday.com)
  • Sophisticated statistical analysis showed a linear increase in mortality with incrementally higher numbers of circulating tumor cells across hormone receptor and HER2 receptor status groups, according to Antonio Giordano, MD, of the University of Texas M.D. Anderson Cancer Center in Houston, and colleagues. (medpagetoday.com)
  • The big hope is that with these new tools -- including circulating tumor cells -- we can better characterize from a biological point of view metastatic breast cancer," Di Leo said at a press conference. (medpagetoday.com)
  • However, it's possible that simply looking at the DNA or other circulating markers might be better than trying to isolate viable cells with a short half-life, commented John Bartlett, PhD, of the Edinburgh Cancer Research Centre in Edinburgh, Scotland, who was the study discussant at the IMPAKT session. (medpagetoday.com)
  • A scanning micrograph of dividing cancer cells. (ucsd.edu)
  • University of California San Diego School of Medicine researchers created a new type of brain cancer model for glioblastoma using stem cells, CRISPR and gene sequencing. (ucsd.edu)
  • A randomized phase III trial performed by the Children's Oncology Group (COG) found 90 percent of children and young adults with T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LL) were alive 4 years after starting treatment regimens on this trial, and 84 percent were cancer-free. (lww.com)
  • A deep-learning model developed using serial image scans of tumors from patients with non-small cell lung cancer (NSCLC) predicted treatment response and survival outcomes better than standard clinical parameters. (medicalxpress.com)
  • Stereotactic Body Radiotherapy (SBRT), a high-dose, precisely delivered radiotherapy, is considered the standard treatment for patients with medically inoperable, node-negative, non-small cell lung cancer (NSCLC). (medicalxpress.com)
  • Using cells from human breast cancers and mouse breast cancer models, researchers at the Johns Hopkins Kimmel Cancer Center say they have significant new evidence that tumor cells exposed to low-oxygen conditions have an advantage when it comes to invading and surviving in the bloodstream. (hopkinsmedicine.org)
  • The experiments mapping the "fate" of the cells in two- and three-dimensional lab-created tissue systems and in live animals specifically showed that cells from a primary cancer exposed to low oxygen levels, or hypoxia, have a four times greater probability of becoming viable circulating tumor cells-and likely spreading to distant tissues-than those under normal oxygen conditions. (hopkinsmedicine.org)
  • Our findings also show that these post-hypoxic cells have six times the probability of forming lung metastases, suggesting that oxygen starvation enhances their metastatic capabilities," says study leader Daniele Gilkes, Ph.D. , assistant professor of oncology and researcher in the breast and ovarian cancer program of the Johns Hopkins Kimmel Cancer Center. (hopkinsmedicine.org)
  • Cancer cells tend to become more aggressive as they adapt to low oxygen levels," says Gilkes, "but we were surprised to find that cells that were exposed to hypoxia in the primary tumor maintained their aggressive features even when they were reoxygenated in the blood. (hopkinsmedicine.org)
  • The study's first author and member of Gilkes' lab, Inês Godet, used this marker to follow the fate of these cells as they multiplied and moved around within 2D and 3D tissue "spheres " and "mini-organs" created in the laboratory, as well as in live mouse models of breast cancer. (hopkinsmedicine.org)
  • Using fluorescence activated cell sorting to capture red or green (oxygen deprived) breast cancer cells, followed by RNA sequencing, the team found that the expression of many gene products, including integrin alpha 10 (ITGA10) and ceruloplasmin (CP) are induced in cells that experienced hypoxia within tumors, but not in cells exposed to hypoxia in the lab. (hopkinsmedicine.org)
  • The tumor-based hypoxia pattern was also better at predicting the survival of patients free of distant metastases, they concluded after studying similar genetic expression data from primary tumors from more than 1000 patients with breast cancer. (hopkinsmedicine.org)
  • Perturbations that enhance or suppress cell death may lead to cancer, neurodegeneration, and inflammatory diseases. (cshlpress.com)
  • This volume is therefore an essential reference for cell and developmental biologists, cancer biologists, and all who wish to explore recent progress in our understanding of cell death programs. (cshlpress.com)
  • We are delighted by these findings which demonstrate that Sutent provides a benefit for patients with advanced, well-differentiated pancreatic islet cell tumors - a rare cancer with limited treatment options," said Dr. Mace Rothenberg, senior vice president of medical development and clinical affairs for Pfizer's Oncology Business Unit. (medicalnewstoday.com)
  • Pfizer is pursuing a broad development program for sunitinib malate and is studying its role in the potential treatment of various solid tumors including advanced breast cancer , advanced non-small cell lung cancer , advanced colorectal cancer , advanced hepatocellular carcinoma and advanced hormone-refractory prostate cancer in Phase 3 trials. (medicalnewstoday.com)
  • Cancer cells with the surface marker profile CD44+/CD24− have previously been described to possess cancer stem cell-like properties. (springer.com)
  • This manuscript evaluates those properties in ovarian cancer cell lines. (springer.com)
  • The proportion of CD44+/CD24− cells corresponded to the clinical aggressiveness of each ovarian cancer cell line histologic subtype. (springer.com)
  • Al-Hajj M, Becker MW, Wicha M, Weissman I, Clarke MF (2004) Therapeutic implications of cancer stem cells. (springer.com)
  • Jordan CT, Guzman ML, Noble M (2006) Cancer stem cells. (springer.com)
  • Joshua B, Kaplan MJ, Doweck I, Pai R, Weissman IL, Prince ME, Ailles LE (2012) Frequency of cells expressing CD44, a head and neck cancer stem cell marker: correlation with tumor aggressiveness. (springer.com)
  • Wu Q, Guo R, Lin M, Zhou B, Wang Y (2011) MicroRNA-200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2. (springer.com)
  • Zhao BC, Zhao B, Han JG, Ma HC, Wang ZJ (2010) Adipose-derived stem cells promote gastric cancer cell growth, migration and invasion through SDF-1/CXCR4 axis. (springer.com)
  • Both sources for collecting stem cells, which are currently used to treat blood cancer patients, were compared and found to have different advantages. (bionews.org.uk)
  • In cancers that affect the production of blood cells , treatment often destroys both the cancer cells and the healthy stem cells that produce the body's blood cells. (bionews.org.uk)
  • This led Dr Fred Appelbaum, executive director at the Seattle Cancer Care Alliance who was not involved in the study, to suggest that stem cells from bone marrow should be used in preference to those from peripheral blood. (bionews.org.uk)
  • The consequences of this survival process may be double-edged because both cancer cells and postmitotic cells use PARC/CUL9-mediated cytochrome c degradation to ensure cell survival. (sciencemag.org)
  • In this study, I determined that histone deacetylase 3 (HDAC3) or histone deacetylase 8 (HDAC8) inhibition caused cell death in ovarian cancer cell lines with a similar effectiveness as generic pan-HDAC inhibition. (harvard.edu)
  • Finally, HDAC3 and HDAC8 inhibition were tested on multiple cell lines with HDAC3 inhibition causing cell death in all ovarian cancer cells line and a lung cancer cell line while and HDAC8 inhibition only causing cell death in ovarian cancer cell lines. (harvard.edu)
  • Background:Financial hardship is a growing challenge for patients with blood cancer who undergo hematopoietic cell transplantation (HCT), and it is associated with poor patient-reported outcomes. (aacrjournals.org)
  • Imfinzi could join Roche's Tecentriq in the previously untreated small cell lung cancer arena. (fiercepharma.com)
  • Right now, Roche's Tecentriq is the only immuno-oncology therapy approved in small cell lung cancer. (fiercepharma.com)
  • While the number of small cell patients is much smaller than the non-small cell lung cancer (NSCLC) group-which Merck currently dominates with its own contender, Keytruda-analysts have predicted Roche could rack up $1.5 billion in the indication. (fiercepharma.com)
  • A small cell lung cancer nod would be the second for AstraZeneca in the broader lung cancer sphere. (fiercepharma.com)
  • The researchers found that patients with diabetes showed worse prognosis in terms of progression-free, overall, and cancer-specific survival before matching (all P (medicalxpress.com)
  • REDWOOD CITY, Calif., Aug. 10, 2015 (GLOBE NEWSWIRE) -- OncoMed Pharmaceuticals, Inc. (Nasdaq:OMED) today reported financial results for the quarter ended June 30, 2015 and provided an update on progress toward 2015 corporate objectives and clinical development milestones, including new data from the Phase 1b clinical trial of demcizumab in non-small cell lung cancer (NSCLC). (cnbc.com)
  • Today, we are updating the survival data for the truncated dose demcizumab cohorts of our Phase 1b clinical trial in non-small cell lung cancer. (cnbc.com)
  • Presented new data from Phase 1b clinical trials of demcizumab (anti-DLL4, OMP-21M18) in patients with first-line advanced non-small cell lung cancer (NSCLC) and pancreatic cancer and for tarextumab (anti-Notch 2/3, OMP-59R5) in small cell lung cancer at the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting. (cnbc.com)
  • Researchers at University of California San Diego School of Medicine report that cancer cells appear to communicate to other cancer cells, activating an internal mechanism that boosts resistance to common chemotherapies and promotes tumor survival. (ucsd.edu)
  • In their new paper, Zanetti and colleagues say cancer cells appear to take the process beyond just affecting bone marrow cells, using transmissible ER stress (TERS) to activate Wnt signaling in recipient cancer cells. (ucsd.edu)
  • Understanding how cellular fitness is gained within the tumor microenvironment is key to understand cooperativity among cancer cells as a way to collective resilience to nutrient starvation and therapies. (ucsd.edu)
  • When cancer cells subject to TERS were implanted in mice, they produced faster growing tumors. (ucsd.edu)
  • In other words, some cells acquire greater fitness and extended survival - another way to generate intra-tumor heterogeneity, which currently represents one of the major obstacles to cancer treatment. (ucsd.edu)
  • Indeed, homeostatic proliferation of T cells can markedly enhance their reactivity to foreign antigens and recent work has shown this may be a therapeutic benefit in cancer immunotherapy ( 23 - 25 ). (rupress.org)
  • Patients who received nelarabine had better survival and fewer CNS relapses," said lead author Kimberly Dunsmore, MD, Professor, Virginia Tech Carilion School of Medicine in Roanoke, at a press briefing before the 2018 ASCO Annual Meeting ( Abstract 10500 ). (lww.com)
  • During the study, the researchers measured circulating tumor cells, using the Veridex Cell Search system, both at baseline and during therapy. (medpagetoday.com)
  • This allowed the researchers to track the types of mutations that caused the emergence of four main survival strategies: tolerance, coexistence, competition and chaos. (eurekalert.org)
  • These results suggest that the conventional threshold of five such cells per 7.5 ml of peripheral blood "probably does not adequately represent the complexity of this prognostic variable," the researchers concluded. (medpagetoday.com)
  • The threshold for determining high versus low risk with regard to circulating tumor cells has been debated -- with some researchers thinking about an any-versus-none threshold and others suggesting a plateau above 10 or 15 cells, Giordano explained in an interview. (medpagetoday.com)
  • Researchers at the University of California, San Diego School of Medicine have identified a microRNA molecule as a surprisingly crucial player in managing cell survival and growth. (ucsd.edu)
  • With let-7 revealed to be a master regulator of metabolism, helping to modulate anabolic growth (the creation of new molecules in cells) with catabolic destruction (the breakdown of molecules in cells), researchers say the overall picture of how cells function becomes more fine-tuned but also more complicated. (ucsd.edu)
  • An analysis by National Institutes of Health researchers has shown that people with sickle cell anemia who took the drug hydroxyurea at the recommended dose had higher survival rates than those who took less than the recommended dose. (nih.gov)
  • Researchers at the National Heart, Lung and Blood Institute (NHLBI) and the National Institute of Diabetes and Digestive and Kidney Diseases reviewed data from 383 people who came to NIH for treatment or evaluation for sickle cell anemia between 2001 and 2010. (nih.gov)
  • Some tumor cells retain parts of this genetic signature as a "hypoxic memory" even after they have been reoxygenated, the researchers found. (hopkinsmedicine.org)
  • To understand what gives PPM1D mutants a competitive advantage, the researchers carried experiments in the lab mixing normal and PPM1D mutant cells together in a dish, growing them together and then exposing them to different environmental conditions. (news-medical.net)
  • The researchers observed abnormal nuclear morphology in atg39 mutants, which were less viable than wild-type cells under a lack of nitrogen. (healthcanal.com)
  • A specialized type of brain cell that tamps down stem cell activity ironically, perhaps, encourages the survival of the stem cells' progeny, Johns Hopkins researchers report. (hopkinsmedicine.org)
  • When stimulated, the cells would indeed activate nearby newborn neurons, the researchers found. (hopkinsmedicine.org)
  • The researchers collected peripheral blood stem cells from responding patients with less than 1% of circulating plasma cells before high-dose melphalan and autologous stem cell transplantation (HDM/ASCT). (cancernetwork.com)
  • However, subgroup analyses did reveal notable differences in survival in patients with acute leukemias between those who received allogeneic blood cells and those who received bone marrow, while no differences were seen in patients with chronic myeloid leukemia, the researchers wrote. (bio-medicine.org)
  • This allows researchers to study the injected cells without having to take the effect of the injection into account as well. (phys.org)
  • VV infects epithelial cells expressing receptors for epidermal growth factor ( 15 , 16 , 17 ), and thus infects many tissues in mice, including those of the ovaries, spleen, liver, and lung. (jimmunol.org)
  • Here we demonstrate that under conditions of dietary restriction or growth factor starvation, where PI3K/mTOR signalling is decreased, matrix-attached human mammary epithelial cells upregulate and internalize β4-integrin along with its matrix substrate, laminin. (harvard.edu)
  • Our study identifies a crosstalk between stromal fibroblasts and epithelial cells under starvation that could be exploited therapeutically to target tumours resistant to PI3K/mTOR inhibition. (harvard.edu)
  • To obtain CSC expression profiles of human patients, the authors sorted 16 patient samples into four cell populations based on the expression of surface markers, and assayed the ability of each subpopulation to engraft in highly immunodeficient mice. (nature.com)
  • PAHSAs reduced T and B cell infiltration and CD4+ and CD8+ T cell activation, while increasing Treg activation in pancreata of NOD mice. (jci.org)
  • PAHSAs promoted β cell proliferation in both NOD mice and MIN6 cells and increased the number of β cells in NOD mice. (jci.org)
  • The mechanism appears to involve a reduction of ER stress and MAPK signaling, since PAHSAs lowered ER stress in NOD mice, suppressed thapsigargin-induced PARP cleavage in human islets, and attenuated ERK1/2 and JNK1/2 activation in MIN6 cells. (jci.org)
  • Those cells are fibroblast delivered from new born SOD knockout mice kidney. (protocol-online.org)
  • Normal T cells activated by superantigen in uninfected mice died as a result of their activation, whereas T cells that were activated during vaccinia infection survived longer in vivo and in culture. (jimmunol.org)
  • Superantigen treatment of mice thus allows for the activation of detectable but limited portions of the available repertoire of normal, primary T cells. (jimmunol.org)
  • We found that T cells responding to superantigen during active VV infection showed prolonged survival thereafter in mice and in culture. (jimmunol.org)
  • The mice carrying disrupted TCTP in neuronal and glial progenitor cells died at the perinatal stage. (mdpi.com)
  • The mechanism may be that the phenotype from specific deletion of TCTP in neural progenitor cells is correlated with the decreased expression of cyclins D2, E2, Mcl-1, Bcl-xL, hax-1, and Octamer-binding transcription factor 4 (Oct4) in conditional knockout mice. (mdpi.com)
  • I examined the role of STAT3 in Schwann cells both in vitro and in vivo using mice with a conditional mutation of STAT3 specifically in Schwann cells. (bl.uk)
  • Remarkably, the severe mtDNA depletion and respiratory chain abnormalities in Tfam-SCKO mice did not affect SC proliferation or survival. (jneurosci.org)
  • In this study, we used mice with conditional deletion of Dicer and DiGeorge syndrome critical region 8 (Dgcr8) to dissect the roles of miRNAs in NK cell activation, survival, and function during viral infection. (jimmunol.org)
  • Many of the inhibitory NKRs, including Ly49 receptors in mice and inhibitory killer cell Ig-like receptors in humans, recognize self-ligands, such as MHC class I molecules. (jimmunol.org)
  • Lack of NK cells renders both human and mice susceptible to certain infections, particularly the herpesviruses, including human cytomegalovirus and MCMV ( 5 ). (jimmunol.org)
  • Therefore, experimental infection of mice with MCMV provides a useful model for studying factors that are important for NK cell activation in vivo. (jimmunol.org)
  • Using BM chimera, we found that serpinB1 deficiency in BM cells was necessary and sufficient to reproduce the BM neutropenia of sB1 −/− mice. (bloodjournal.org)
  • 18 We have recently shown that mice lacking the serine protease inhibitor serpinB1 ( sB1 −/− ) have reduced PMN survival in the lungs following Pseudomonas infection and that these mice have a profound reduction in mature PMN numbers in the BM. (bloodjournal.org)
  • A single dose of either ADC showed potent in vivo anti-leukemia activity in mice bearing established human leukemia cell lines. (businesswire.com)
  • Both ADCs also significantly improved the survival of mice engrafted with human leukemia cells from AML patients, including leukemias that were resistant to multiple lines of therapy including previous allogeneic bone marrow transplant. (businesswire.com)
  • Surprisingly, NK survival is also compromised after transfer of cells into IL-15Rα −/− mice, implying that IL-15 responsiveness by bystander cells is critical for NK maintenance. (rupress.org)
  • mice showed normal survival and bone marrow cellularity and were used as controls. (pubmedcentralcanada.ca)
  • We identify a previously unknown function for activating transcription factor 5 (ATF5) in the apoptotic susceptibility of β cells. (pnas.org)
  • Thus, for many but not all apoptotic signals, the balance between these competing activities determines cell fate. (sciencemag.org)
  • Fluorescence signals below the G 0 /G 1 peak typically correspond to apoptotic cells with fragmented DNA. (cellsignal.com)
  • After manipulating levels of TCF7L2, we examined glucose-induced insulin secretion by perifusion and β-cell survival after exposure to pro-apoptotic glucose concentrations and cytokines. (diabetesjournals.org)
  • The second patient who achieved complete response is currently at 14 months survival with no signs of recurrence. (mesothelioma.com)
  • We identified TET2 epigenetic enzyme as a key factor controlling SCCC numbers, survival, and tumor recurrence. (jci.org)
  • The epidemiological profile of the patients was established (gender, age and any associated skin neoplasms), staging, topographical distribution, the initial treatment implemented, the time between the appearance of the signs/symptoms and the initiation of specialist treatment, types of postoperative complications, progression with respect to local and distant recurrence, and 1 and 2-year survival rates. (scielo.br)
  • Enhanced molecular understanding of T-ALL biology will ultimately facilitate a targeted therapy driven approach that can improve survival of refractory T-ALL patients. (nature.com)
  • We performed comprehensive molecular profiling of infiltrating CD4 + T cells isolated from untreated invasive primary tumors and found that the infiltrating T cell subpopulations included follicular helper T (Tfh) cells, which have not previously been found in solid tumors, as well as Th1, Th2, and Th17 effector memory cells and Tregs. (jci.org)
  • New drugs were needed to improve survival rates for T-ALL/LL," said Dunsmore, adding that nelarabine was known to be a T-cell specific drug with success in relapsed patients. (lww.com)
  • New clinical trial findings show that a therapeutic regimen involving transplantation of a person's own blood-forming stem cells can improve survival and quality of life for people with severe scleroderma, a life-threatening autoimmune disease. (enewspf.com)
  • His group retrospectively analyzed outcomes for 516 consecutive metastatic breast patients evaluated at M.D. Anderson, all of whom had circulating tumor cells measured by Cell Search before any line of new treatment was started. (medpagetoday.com)
  • Impact:When assessing the effectiveness of interventions to ameliorate familial financial burden among HCT, the focus should be on patient-reported outcomes rather than survival. (aacrjournals.org)
  • The goal of this study was to produce an image of CD4 + T cells infiltrating breast tumors using limited ex vivo manipulation to better understand the in vivo differences associated with patient prognosis. (jci.org)
  • I found that STAT3 is activated by, and supports survival following stimulation by autocrine factors secreted by Schwann cells both in vitro and following nerve injury in vivo. (bl.uk)
  • An anti-CD117 ADC conjugated with amanitin potently depleted human and non-human primate hematopoietic stem cells and progenitors in vivo . (businesswire.com)
  • Importantly, he said the research may explain previous findings by other groups showing that individual tumor cells within a uniform genetic lineage can acquire functionally different behaviors in vivo . (ucsd.edu)
  • However, the impact of aging on the production of survival factors for effector/memory T cells and plasma cells in the human BM has not been studied. (nih.gov)
  • The myoblastic C2C12 cell line, 3T3 fibroblasts, chondrocytes, and hepatocytes all displayed appreciable but varying metabolic activity with exposure times up to 1 min. (pnas.org)
  • With depressurization times of 4 min, cell population metabolic activity was ≥70% of the control population. (pnas.org)
  • The single most protective and unifying feature of cold-tolerance in hibernating and neonatal mammals is the same one that ensures their enhanced survival in O 2 -limiting conditions: a regulated metabolic depression. (biologists.org)
  • In contrast, an early mismatch between ATP supply and demand in 'anoxia- and cold-sensitive cells' leads to a forced hypometabolism which is, in effect, early metabolic failure. (biologists.org)
  • The metabolic control systems in HSCs are poorly understood although these cells have been shown to be highly sensitive to energetic and oxidative stress and must be able to shift between quiescence and highly proliferative states to maintain the haematopoietic system under varying physiological conditions 1 - 5 . (pubmedcentralcanada.ca)
  • Given the importance ofHSCdynamics to the haematopoietic system and the sensitivity of haematopoietic cells to metabolic stress, we sought to investigate the function of Lkb1 in haematopoiesis. (pubmedcentralcanada.ca)
  • The findings suggest that patients who underwent surgery had a greater survival rate compared with those that did not. (hindawi.com)
  • Most recently, a phase 1 clinical trial testing CAR-T cell therapy targeting mesothelin in combination with PD-1 inhibitors has shown success in achieving stable disease and extending survival for pleural mesothelioma patients. (mesothelioma.com)
  • Chapel Hill, NC - Leukemia and lymphoma patients who receive life-saving stem cell or bone marrow transplants often experience chronic side effects that significantly decrease quality of life, can last a lifetime, and ultimately affect their long-term survival. (eurekalert.org)
  • For patients who received bone marrow or stem cells, it is estimated that 40-70 percent may experience chronic GVHD. (eurekalert.org)
  • Dormant or slow-cycling tumor cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery and adjuvant therapy. (jci.org)
  • We have shown the enhanced chemoresistance of SCCCs and revealed 5hmC as a biomarker for their clinical identification and TET2 as a potential drug target for SCCC elimination that could extend patients' survival. (jci.org)
  • In the [earlier] study favoring pembrolizumab, patients needed to have PD-L1 expression on at least 1% of tumor cells, whereas in the studies favoring nivolumab, patients were not selected on the basis of PD-L1 expression," he wrote. (cancer.gov)
  • The statistical model "trained" using 60% of the patients' predicted survival probabilities matching the Kaplan-Maier estimates for the remaining 40% in the validation set. (medpagetoday.com)
  • Those patients with T-cell ALL also received either prophylactic or therapeutic cranial irradiation to prevent or treat brain metastases. (lww.com)
  • Contrary to results from previous, smaller trials, patients with T-ALL who received escalating doses of methotrexate did better than those who received high-dose methotrexate (4-year disease-free survival with escalating dose was 89.8% vs. 78% with high-dose methotrexate). (lww.com)
  • In the future, the unique features of the hypoxic cells might be used as biomarkers to identify patients at risk for metastasis, or might be targeted directly by therapies to prevent or limit metastasis, the research team suggested. (hopkinsmedicine.org)
  • Pfizer Inc announced that a phase 3 clinical trial of Sutent (sunitinib malate) has been stopped early after the drug showed significant benefit in patients with advanced pancreatic islet cell tumors, also known as pancreatic neuroendocrine tumors. (medicalnewstoday.com)
  • These and previously reported phase 2 data contribute to the growing body of evidence indicating activity with sunitinib in patients with pancreatic islet cell tumors. (medicalnewstoday.com)
  • This phase III trial of sunitinib in patients with advanced pancreatic islet cell tumors was initiated based on the results of a earlier phase II trial published in the Journal of Clinical Oncology (July 2008). (medicalnewstoday.com)
  • Survival rates of patients needing bone marrow transplants are unaffected by whether they receive stem cells from blood or bone marrow, say scientists. (bionews.org.uk)
  • The use of stem cells from blood has rapidly grown due to easy accessibility and their ability to grow quickly, however whether the origin of the stem cells influences the survival of patients has not previously been investigated. (bionews.org.uk)
  • MONDAY, Feb. 1 (HealthDay News) -- Long-term survival rates are similar for leukemia patients who've had either peripheral blood stem cell (PBSC) or bone marrow transplants, a new European study says. (bio-medicine.org)
  • Among patients with acute lymphoblastic leukemia, 10-year leukemia-free survival probability was 28.3 percent in the bone marrow transplant group, compared with 13 percent in the PBSC transplant group. (bio-medicine.org)
  • The red blood cell survival was reduced in the majority of patients in each group when compared with the red blood cell survival from a normal control group. (ahajournals.org)
  • A detailed analysis of the survival curves suggested that in many patients there was more than one population of red blood cells. (ahajournals.org)
  • Methods:We sought to describe the association of financial hardship with survival after HCT in a prospectively assembled cohort of patients from three large transplant centers (n=325). (aacrjournals.org)
  • Thirty-two patients with Merkel cell carcinoma were evaluated retrospectively. (scielo.br)
  • All patients included in this analysis (N = 319) were treated with an intensified frontline regimen that included cytarabine, rituximab (Rituxan), and consolidation with high-dose therapy and autologous stem-cell transplant. (onclive.com)
  • Magenta Therapeutics' C200 and C100 programs are designed with the dual intent of selectively eliminating the necessary cells to enable a successful transplant and reducing disease burden in patients with active disease or in patients who are at high risk of disease relapse. (businesswire.com)
  • We are pleased to observe this prolonged tail of the survival curve for patients treated with truncated dosing demcizumab, which is the regimen being utilized in our Phase 2 DENALI clinical trial. (cnbc.com)
  • The fact that the prolonged tail of the survival curve is observed for patients receiving both continuous and truncated demcizumab dosing is encouraging. (cnbc.com)
  • A comparison of extensively versus minimally infiltrated tumors showed that CXCL13-producing CD4 + Tfh cells distinguish extensive immune infiltrates, principally located in tertiary lymphoid structure germinal centers. (jci.org)
  • In chronic Graft vs. Host Disease (GVHD), the differences between the donor bone marrow cells and the recipient's body often cause these immune cells to recognize the recipient's body tissues as foreign and the newly transplanted cells attack the transplant recipient's body. (eurekalert.org)
  • In summary, our results demonstrate the role of inflammation and oxidative stress in age-related changes of immune cell survival factors in the BM, suggesting that antioxidants may be beneficial in counteracting immunosenescence by improving immunological memory in old age. (nih.gov)
  • Scientists have identified key changes in immune cells within cancerous tumours that could help improve the development of treatments. (medicalxpress.com)
  • Thus, PAHSAs delayed the onset of T1D and reduced its incidence by attenuating immune responses and exerting direct protective effects on β cell survival and function. (jci.org)
  • To understand how such activated cells survive to participate in immune responses, we studied the effects of viral infection on T cells responding to an unrelated superantigen. (jimmunol.org)
  • Resistance to infections depends upon effective immune responses in which T cells stimulated by the invading organism do not all die rapidly. (jimmunol.org)
  • Finally, doctors infused the participant's own blood stem cells to rebuild the bone marrow and a normally functioning immune system. (enewspf.com)
  • NK cells are thought to play an important role in immune defense against pathogens ( 1 - 3 ) and tumors ( 4 - 7 ). (rupress.org)
  • However, upon recognition of chemical signals imparted by oxidative and electrophilic molecules, Nrf2 is released from Keap1, escapes proteasomal degradation, translocates to the nucleus, and transactivates the expression of several dozen cytoprotective genes that enhance cell survival. (mendeley.com)
  • In the initial phase, the cell senses signals released in response to lack of nutrients, hypoxia, or other forms of stress. (sigmaaldrich.com)
  • NK cell activation and function are determined by a balance of signals transmitted by inhibitory and activating NK cell receptors (NKRs) ( 1 ). (jimmunol.org)
  • In each instance, receiving stress signals caused cells to survive better. (ucsd.edu)
  • However, it is currently unclear whether NK cells have a fixed lifespan as nondividing cells or whether they can respond to homeostatic signals to maintain the size of the NK pool. (rupress.org)
  • Gilkes and her team also identified a pattern of genetic expression in post-hypoxic cells that appears to help the cells survive oxidative stress when they enter the bloodstream. (hopkinsmedicine.org)
  • if they do survive, the new cells migrate to a permanent home in the brain and forge connections called synapses with other cells. (hopkinsmedicine.org)
  • In a new study to be found in Scientific Reports published by Nature , they show that with this method, nine out of ten cells survive being injected with foreign molecules. (phys.org)
  • This proof was necessary, because previous techniques such as microinjection harm the cells so much that most do not survive the treatment,' says Hennig. (phys.org)
  • Using this new method, nine out of ten cells survive being prepared for microscopic studies. (phys.org)
  • Through stress transmission, tumor cells help neighboring tumor cells to cope with these adverse conditions and eventually survive and acquire growth advantages. (ucsd.edu)
  • We find that mature NK cells survive but do not proliferate in hosts which possess an endogenous NK pool. (rupress.org)
  • Based on survival data, we developed a single-step scCO 2 technique for the rapid production of biodegradable poly( dl -lactic acid) scaffolds containing mammalian cells. (pnas.org)
  • By using optimum cell-survival conditions, scCO 2 was used to process poly( dl -lactic acid) containing a cell suspension, and, upon pressure release, a polymer sponge containing viable mammalian cells was formed. (pnas.org)
  • Standard methods of combining mammalian cells and synthetic polymers for biotechnological applications ( 1 - 3 ) must minimize disruption to the cell component from fluctuations in solvent composition, temperature, pressure, and shear forces ( 4 , 5 ). (pnas.org)
  • We hypothesized that a similar one-step scCO 2 processing technique might be used to produce biodegradable foams containing mammalian cells. (pnas.org)
  • In mammalian cells, autophagy occurs constitutively at basal rates and its primary function is to protect cells under stress conditions. (sigmaaldrich.com)
  • Ion leakage across cell membranes occurs as a result of both intracellular and extracellular ions drifting towards their thermodynamic equilibrium. (biologists.org)
  • In conclusion, we have unveiled a new cytotoxic function for the serine protease CG and showed that serpinB1 is critical for maintaining PMN survival by antagonizing intracellular CG activity. (bloodjournal.org)
  • Tendon fibroblasts cultured from the core of the equine SDFT were subjected to a temperature of 45 degrees C in an in vitro system for 0-180 min, and cell survival fraction was measured and compared with that for equine dermal fibroblasts and a commercial rat kidney fibroblast cell line (NRK 49F). (biologists.org)
  • Tendon fibroblasts were significantly more resistant to hyperthermia than NRK 49F cells after 30, 45 and 60 min of heating and significantly more resistant than dermal fibroblasts after 45 and 60 min of heating. (biologists.org)
  • In this study I investigated the effects of BMP in the Schwann cell lineage in vitro. (bl.uk)
  • Both the anti-CD117 amanitin ADC (C200 program) and the anti-CD45 amanitin ADC (C100 program) showed potent killing of human hematopoietic stem cells and human leukemia cell lines expressing these targets in vitro . (businesswire.com)
  • The Company's three hybrid journals - Development, Journal of Cell Science and Journal of Experimental Biology - have chosen the 'transformative' route towards Open Access. (biologists.org)
  • Klein, Robert is the author of 'Basic Concepts in Cell Biology and Histology A Student's Survival Guide' with ISBN 9780070369306 and ISBN 0070369305. (valorebooks.com)
  • For example, necroptosis and autophagy and their overlap in survival and drug resistance have only recently begun to be understood. (frontiersin.org)
  • Autophagy is a fundamental process used by cells to degrade unnecessary components in times of starvation, releasing energy stores that help promote cell survival. (ucsd.edu)
  • In autophagy cells destroy their own cytoplasmic components in a very systematic manner and recycle them. (sigmaaldrich.com)
  • Autophagy can also be induced in mTOR-independent manner by lowering the levels of myo-inositol-1, 4, 5-triphosphate in cells by using lithium, carbamezapine, or sodium valproate. (sigmaaldrich.com)
  • The term autophagy derives from the Greek auto-, "self" and phagein, "to eat" and refers to processes that lead to the degradation of cell constituents. (healthcanal.com)
  • Alternatively disease-induced autophagy may diminish the health and survival of the afflicted organism. (healthcanal.com)
  • The public is being invited to a screening of a documentary on the disease titled Sickle-Cell Disease: Stories of Strength, Survival and Spirit at the Faculty of Law, The University of the West Indies, Mona, this evening at 6. (jamaica-gleaner.com)
  • What we decided was that what we really needed was a more meaningful way to explain to the Jamaican public why sickle-cell disease should be taken seriously, and we thought about developing a documentary. (jamaica-gleaner.com)
  • Sickle-cell disease (SCD) is an inherited blood disorder in which there are not enough healthy red blood cells to carry adequate amounts of oxygen throughout the body. (jamaica-gleaner.com)
  • Senescent cells undergo morphological, structural and functional changes which are influenced by a number of variables, including time, stress, tissue, and cell type. (rug.nl)
  • The heterogeneity of the senescent phenotype is exemplified by the many biological properties that senescent cells can cover. (rug.nl)
  • The advent of innovative model organisms has demonstrated a functional role of senescent cells during embryogenesis, tissue remodeling, tumorigenesis and aging. (rug.nl)
  • Our data indicate similar phenotypes for Dicer- and Dgcr8-deficient NK cells, which strongly suggest that these processes are regulated by miRNAs. (jimmunol.org)
  • Superantigens, when presented by the appropriate MHC class II molecule, activate T cells bearing particular Vβs as part of their TCRs. (jimmunol.org)
  • These studies identify NF-κB as an important signaling molecule in α v β 3 integrin-mediated endothelial cell survival. (rupress.org)
  • Because these statistics are based on the experience of groups of people, they cannot be used to predict a particular person's chances of survival. (cancer.ca)
  • Matthias Simonis et al, Survival rate of eukaryotic cells following electrophoretic nanoinjection, Scientific Reports (2017). (phys.org)