Cell surface glycoprotein cd53. Medical search. Frequent questions

CD58 , or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages . (wikidoc.org)
The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. (wakehealth.edu)
B-lymphocyte antigen CD20 or CD20 is an activated- glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase ( CD45 R+, CD117 +) and progressively increasing in concentration until maturity. (wikidoc.org)
This gene encodes a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells . (wikidoc.org)

The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. (neobiotechnologies.com)
The organization of the SELPLG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters. (wikidoc.org)
P-selectin glycoprotein ligand-1 ( PSGL-1 ) is a glycoprotein found on white blood cells and endothelial cells that binds to P-selectin (P stands for platelet ), which is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). (wikidoc.org)
Glycoprotein Ib (platelet), beta polypeptide ( GP1BB ) also known as CD42c ( C luster of D ifferentiation 42c ), is a protein that in humans is encoded by the GP1BB gene. (wikidoc.org)
Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. (wikidoc.org)
It is part of the Glycoprotein Ib-IX-V Receptor Complex (GPIb-V-IX) system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. (wikidoc.org)

Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. (wikipedia.org)
The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. (wikipedia.org)
The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. (neobiotechnologies.com)
To examine on cell labeling that is specific to HER2 as opposed to simply being on the membrane, we compared the labeling patterns for the eight Traz-catalyst species to random labeling of membrane proteins using a metabolically integrated fatty acid catalyst. (bvsalud.org)
Human leukocyte antigens (HLA) display peptides largely from intracellular proteins on the surface of cells in major histocompatibility complex (MHC)-peptide complexes. (bvsalud.org)

Thus, proper identification of peptides and the corresponding presenting HLA allele in disease phenotypes is important for the design and execution of therapeutic strategies using engineered T-cell receptors or antibodies. (bvsalud.org)
This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation , when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell receptors are reactive to. (wikidoc.org)
In summary, signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. (iiab.me)
Like many cell surface receptors/markers, CD4 is a member of the immunoglobulin superfamily . (wikidoc.org)

1997). "Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin" . (wikidoc.org)
The protein has no known natural ligand [4] and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. (wikidoc.org)

Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. (neobiotechnologies.com)
Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. (neobiotechnologies.com)
Selectins are part of the broader family of cell adhesion molecules . (wikidoc.org)
However, inflammation causes the expression of cell adhesion molecules (CAM) such as P-selectin on the surface of the blood vessel wall. (wikidoc.org)
This interaction results in "rolling" of the white blood cell on the endothelial cell surface followed by stable adhesion and transmigration of the white blood cell into the inflamed tissue. (wikidoc.org)
It binds to CD2 (LFA-2) [3] [4] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. (wikidoc.org)
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. (antibodies-online.com)

CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. (neobiotechnologies.com)

GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. (wikidoc.org)

The first step in this interaction process is carried out by PSGL-1 interacting with P-selectin and/or E-selectin on endothelial cells and adherent platelets. (wikidoc.org)

HER2 is colocalised and most of the time, coamplified with the gene GRB7, which is a proto-oncogene associated with breast, testicular germ cell, gastric, and esophageal tumours. (iiab.me)

Ectodomain phosphatase/phosphodiesterase-1 (ENPP1) is overexpressed on cancer cells and functions as an innate immune checkpoint by hydrolyzing extracellular cyclic guanosine monophosphate adenosine monophosphate (cGAMP). (bvsalud.org)

CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells . (wikidoc.org)

Obese mice administered anti-B cell CD-20 antibodies, however, did not become less responsive to insulin and as a result did not develop diabetes mellitus or the metabolic syndrome, the posited mechanism being that anti-CD20 antibodies rendered the T cell antibodies dysfunctional and therefore powerless to cause insulin desensitivity by a B cell antibody-modulated autoimmune response. (wikidoc.org)

Human CD53 is a tetraspan cell surface glycoprotein found on all hemopoetic cells except platelets and red blood cells. (adipogen.com)
CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. (neobiotechnologies.com)
As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. (wikidoc.org)

The cellular restriction factor BST-2/tetherin (also known as CD317 or HM1.24) potently restricts HIV-1 release by retaining viral particles at the cell surface in many cell types, including primary cells such as macrophages. (biomedcentral.com)
In molecular biology , CD4 ( cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells , monocytes , macrophages , and dendritic cells . (wikidoc.org)

Members of this nascent protein family are characterized by common structural features and similar intron / exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. (wikidoc.org)

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)

This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. (wikipedia.org)
Phosphorylated ITAM motifs on CD3 recruit and activate SH2 domain-containing protein tyrosine kinases (PTK) such as Zap70 to further mediate downstream signalling through tyrosine phosphorylation, leading to transcription factor activation including NF-κB and consequent T cell activation. (wikidoc.org)
HIV-1 uses CD4 to gain entry into host T-cells and achieves this through its viral envelope protein known as gp120 . (wikidoc.org)
Following a structural change in another viral protein ( gp41 ), HIV inserts a fusion peptide into the host cell that allows the outer membrane of the virus to fuse with the cell membrane . (wikidoc.org)

We now report that BST-2/tetherin expression in myeloid (myDC) and monocyte-derived dendritic cells (DC) can be significantly up-regulated by IFN-α treatment and TLR-4 engagement with LPS. (biomedcentral.com)

Dendritic cells and their subsets, located at mucosal surfaces, are among the first immune cells to encounter disseminating pathogens. (biomedcentral.com)
However, BST-2/tetherin does not efficiently restrict HIV-1 infection in immature dendritic cells. (biomedcentral.com)
Dendritic cells (DC) are critical initiators of immune responses after encountering a pathogen at mucosal sites [ 1 ]. (biomedcentral.com)

HER2 mutations have been found in non-small-cell lung cancers (NSCLC) and can direct treatment. (iiab.me)
[6] [7] It is found on B-cell lymphomas , hairy cell leukemia , B-cell chronic lymphocytic leukemia , and melanoma cancer stem cells . (wikidoc.org)
CD20 positive cells are also sometimes found in cases of Hodgkins disease , myeloma , and thymoma . (wikidoc.org)

These complexes provide a biological window into the cell, and peptides derived from disease-associated antigens can serve as biomarkers and therapeutic targets. (bvsalud.org)

T cells displaying CD4 molecules (and not CD8 ) on their surface, therefore, are specific for antigens presented by MHC II and not by MHC class I (they are MHC class II-restricted ). (wikidoc.org)

Human sezary cells. (adipogen.com)
CD4+ T helper cells are white blood cells that are an essential part of the human immune system. (wikidoc.org)

SELPLG codes for PSGL-1, the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. (wikidoc.org)

CD20 is the target of the monoclonal antibodies rituximab , ocrelizumab , obinutuzumab , ofatumumab , ibritumomab tiuxetan , tositumomab , and ublituximab , which are all active agents in the treatment of all B cell lymphomas , leukemias , and B cell-mediated autoimmune diseases. (wikidoc.org)
An inflammation response that mobilizes both T and B cells results in the creation of antibodies against these cells, causing them to become less responsive to insulin by an as-yet unknown mechanism and promoting hypertension , hypertriglyceridemia , and arteriosclerosis , hallmarks of the metabolic syndrome . (wikidoc.org)

The cell surface proteome, or surfaceome, is encoded by more than 4000 genes, but we are only beginning to understand the complexes they form. (bvsalud.org)

Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. (mdpi.com)

In contrast to HeLa or 293T cells, infectious HIV-1 release in immature DC and IFN-α-matured DC was only modestly affected in the absence of Vpu compared to wild-type viruses. (biomedcentral.com)
They are called helper cells because one of their main roles is to send signals to other types of immune cells, including CD8 killer cells, which then destroy the infectious particle. (wikidoc.org)

A link between the immune system 's B cells and diabetes mellitus has been determined. (wikidoc.org)

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. (neobiotechnologies.com)
Lck is essential for the activation of many molecular components of the signaling cascade of an activated T cell. (wikidoc.org)

In mice it seems to be an immune factor regulating T-cell checkpoints , and it could be a target for future checkpoint inhibitor anti-cancer drugs. (wikidoc.org)
It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. (childrensmercy.org)

May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. (neobiotechnologies.com)

PSGL-1 is expressed on all white blood cells and plays an important role in the recruitment of white blood cells into inflamed tissue: White blood cells normally do not interact with the endothelium of blood vessels. (wikidoc.org)
Immunohistochemistry can be used to determine the presence of CD20 on cells in histological tissue sections. (wikidoc.org)

White blood cells present in flowing blood can interact with CAM. (wikidoc.org)

Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor. (iiab.me)

Because CD20 remains present on the cells of most B-cell neoplasms , and is absent on otherwise similar appearing T-cell neoplasms, it can be very useful in diagnosing conditions such as B-cell lymphomas and leukaemias. (wikidoc.org)

In contrast, in LPS-mediated mature DC, BST-2/tetherin exerted a significant restriction in transfer of HIV-1 infection to CD4 + T cells. (biomedcentral.com)
In conclusion, we demonstrate that TLR-4 engagement in immature DC significantly up-regulates the intrinsic antiviral activity of BST-2/tetherin, during cis-infection of CD4 + T cells across the DC/T cell virological synapse. (biomedcentral.com)
If CD4 cells become depleted, for example in untreated HIV infection, or following immune suppression prior to a transplant, the body is left vulnerable to a wide range of infections that it would otherwise have been able to fight. (wikidoc.org)
HIV infection leads to a progressive reduction in the number of T cells expressing CD4 . (wikidoc.org)

[5] . Genomic region containing the single-nucleotide polymorphism rs1335532, associated with high risk of multiple sclerosis , has enhancer properties and can significantly boost the CD58 promoter activity in lymphoblast cells. (wikidoc.org)

A set of eight single site-specific Ir-catalytic centers were engineered into Traz to study intra- and inter-molecular labeling in vitro and on cells by mass spectrometry. (bvsalud.org)

Anatomy24

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