Cell seeding approach stem cells. Medical search. Frequent questions

Scientists from the Worcester Polytechnic Institute, in Massachusetts, have shown that cells derived from human bone marrow, known as mesenchymal stem cells, can survive on the threads and maintain their ability to differentiate into different cell types after being sewn through a collagen matrix that mimics tissue. (technologyreview.com)
For example, in human studies of injected mesenchymal stem cells, only one percent to about 10 percent of injected cells remained at the site after injection. (technologyreview.com)
About 10,000 mesenchymal cells can inhabit a two-centimeter length of bundled threads. (technologyreview.com)
While both animal and human studies show that mesenchymal cells can boost heart function, it's not clear how. (technologyreview.com)
Researchers at Mayo Clinic have identified mesenchymal stem cells (MSCs) as a potential way to address the problem. (scienceboard.net)
Stiffness affects the type of cell resulting from differentiation: cells differentiate into neural, mesenchymal, and bone with increasing scaffold stiffness [ 19 ]. (biomedcentral.com)
She developed a process to fabricate a stratified scaffold based on alginate hydrogel laden with human mesenchymal stem cells (MSCs) from the aspirate bone marrow. (universityofgalway.ie)
The aim was to accelerate tissue regeneration by adsorbing growth factors and/or seeding human mesenchymal stem cells on the biomaterial. (universityofgalway.ie)
Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
2016). Mesenchymal Stem/Stromal Cells seeded on cartilaginous endplates promote Intervertebral Disc Regeneration through Extracellular Matrix Remodeling . (up.pt)
We also do a lot of cell culture work using mesenchymal stromal cells and induced pluripotent stem cells, which we seed onto 96 well plates using the VIAFLO pipettes. (integra-biosciences.com)
Many companies approach us at a later stage of project development and are often interested in using products such as myMATRIX, which is formulated for growing human mesenchymal stromal cells in serum-free media. (integra-biosciences.com)
Where they had a "planted" mesenchymal stem cells - cells found in marrow that typically give rise to bone - the researchers found not just bone cells, but cells that make up the lining of blood vessels as well. (leavealegacymn.org)
Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane. (qmul.ac.uk)
We have demonstrated previously that adult human synovial membrane-derived mesenchymal stem cells (hSM-MSCs) have myogenic potential in vitro (De Bari, C., F. Dell'Accio, P. Tylzanowski, and F.P. Luyten. (qmul.ac.uk)
These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)

Seeding hiPSC aggregates into biomaterial scaffolds can control their differentiation into specific tissue types. (biomedcentral.com)
Here we develop and analyze a mathematical model of hiPSC aggregate behavior when seeded on melt electrospun scaffolds with defined topography. (biomedcentral.com)
We used ordinary differential equations to model the different cellular populations (stem, progenitor, differentiated) present in our scaffolds based on experimental results and published literature. (biomedcentral.com)
Alternatively, hydrogel scaffolds laced with a drug can recruit stem cells, while decellularized tissue re-seeded with donor cells from the patient help avoid rejection by the host's immune system. (sociable.co)
University of Wisconsin-Madison researchers are investigating de-cellularized plant husks as potential 3D scaffolds which, when seeded with human stem cells, could lead to a new class of biomedical implants and tailored tissues. (zmescience.com)
Joining this noblest of scientific traditions, UWM scientists have turned to de-celled husks of plants such as parsley, vanilla, or orchids to create 3D scaffolds which can be seeded with human stem cells and optimized for growth in lab cultures. (zmescience.com)
Even better, the team observed that stem cells seeded into the scaffolds tended to align to the scaffold's structure. (zmescience.com)
Fabrication and surface modification of macroporous poly(L-lactic acid) and poly(L-lactic-co-glycolic acid) (70/30) cell scaffolds for human skin fibroblast cell culture[J]. J Biomed Mater Res, 2002, 62(3):438-446. (sdu.edu.cn)
The cytocompatibility of PLGA scaffolds coated with different concentration of chitosan with schwann cells in vitro[J]. Chin J Aesth Med, 2009, 18(11):1627- 1631. (sdu.edu.cn)
Co-transplantation of neural stem cells and Schwann cells within poly (L-lactic-co-glycolic acid) scaffolds facilitates axonal regeneration in hemisected rat spinal cord[J]. Chin Med J, 2013, 126(5):909-917. (sdu.edu.cn)
Another group engineered tendon constructs by rolling tenocyte-seeded SIS scaffolds into tubular constructs that could be mounted into custom loading frames for static or dynamic loading within an incubator. (researchgate.net)
Basement Membrane of Tissue Engineered Extracellular Matrix Scaffolds Modulates Rapid Human Endothelial Cell Recellularization and Promote Quiescent Behavior After Monolayer Formation. (mayo.edu)
Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)

To ensure that cells to be transplanted are healthy and normal, the ImageXpress Micro System is used to analyze different cell lines, cell populations, cell differentiation properties in a high throughput fashion. (moleculardevices.com)
For this reason, our group has recently described and patented a method to obtain cardiac stem cells (CSCs) from small biopsies of myocardium and grow them through several generations in the laboratory without losing differentiation potential. (derstandard.at)
Controlling the differentiation of human iPSCs into functional tissues remains difficult because complicated cell signaling networks regulate this process [ 5 - 9 ]. (biomedcentral.com)
While previously differentiation was thought to be irreversible, mature cells can revert from the terminally differentiated state into the stem state in both nature and the lab [ 9 , 15 ]. (biomedcentral.com)
Collectively these mechanisms lead to major differences in the overall effect of the signal on stem cell behavior in terms of proliferation versus differentiation. (biomedcentral.com)
In addition to stiffness, porosity affects stem cell differentiation and proliferation because contact induces these processes, but excessive contact inhibits aggregate growth. (biomedcentral.com)
Ongoing and future applications include 100-port valves and systems for optimizing the differentiation of induced pluripotent stem cells, a 10,000 channel yeast MicroChemostat, and a MicroDialysis imager, all with direct injection into a mass spectrometer. (selectbiosciences.com)
For example, in the future, if you want to replace a failing liver, you could put the cells in a scaffold or microenvironment that strongly promotes liver cell differentiation and place the cell-seeded scaffold into the liver to let them differentiate in the optimal macroenvironment. (stanford.edu)
Co-transplantation of schwann cells promotes the survival and differentiation of neural stem cells transplanted into the injured spinal cord[J]. Dev Neurosci, 2005, 27(1):20-26. (sdu.edu.cn)
Tellus's lead candidate, TT-20, is derived from a class of molecules found in breast milk, which promote oligodendrocyte differentiation in postnatal neural stem cell populations. (tellustherapeutics.com)

In adults, stem cells act as a repair system for the body, replenishing specialised cells, and maintaining the normal turnover of regenerative organs such as blood, skin or intestinal tissues. (derstandard.at)
Human induced pluripotent stem cells (hiPSCs) can form any tissue found in the body, making them attractive for regenerative medicine applications. (biomedcentral.com)
These newer approaches may indeed encourage growth of otherwise non-regenerative tissue, but because they do not adapt to the changing state of a wound, their impact is limited. (sociable.co)
Plants are really special materials as they have a very high surface area to volume ratio, and their pore structure is uniquely well-designed for fluid transport," says William Murphy, professor of biomedical engineering and co-director of the UW-Madison Stem Cell and Regenerative Medicine Center, who coordinated the team's efforts. (zmescience.com)
7] Gardner R L. Stem cells and regenerative medicine: principles, prospects and problems[J]. C R Biol, 2007, 330(6-7):465-473. (sdu.edu.cn)
This technique is simpler than existing approaches and reliably produces healthy HIOs of predictable size, which could make it invaluable for translational research and regenerative medicine in the future. (sciencedaily.com)
Aspen's proprietary approach was developed by the company's co-founders, Jeanne F. Loring, Ph.D., Professor Emeritus and founding director of the Center for Regenerative Medicine at The Scripps Research Institute, and Andres Bratt-Leal, Ph.D., a former post-doctoral researcher in Dr. Loring's lab. (techstartups.com)
Microglia-the resident immune cells of the brain-are activated after brain lesions, e.g., cerebral ischemia, and polarize towards a classic "M1" pro-inflammatory or an alternative "M2" anti-inflammatory phenotype following characteristic temporo-spatial patterns, contributing either to secondary tissue damage or to regenerative responses. (biomedcentral.com)
Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue to revitalize teeth. (bvsalud.org)
One novel approach to restore tooth structure is based on regenerative endodontic procedures by application of tissue engineering. (bvsalud.org)
Regenerative endodontic procedures can be defined as biologically based procedures designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex. (bvsalud.org)
The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
The most valuable cells for regenerative endodontics are postnatal or adult stem cells. (bvsalud.org)
In vivo conversion of dopamine neurons in mouse models of Parkinson's disease - a future approach for regenerative therapy? (lu.se)

The ability to use autologous dental progenitor cells (DPCs) to form organized periodontal tissues on titanium implants would be a significant improvement over current implant therapies. (nih.gov)
Further refinement of this approach will facilitate the development of clinically relevant methods for autologous PDL regeneration on titanium implants in humans. (nih.gov)
Here, we demonstrated the feasibility of using autologous urine-derived stem cells (USCs) seeded on small intestinal submucosa (SIS) to repair a urethral defect in a rabbit model. (biomedcentral.com)
Autologous USCs were obtained and characterized, and their capacity to differentiate into urothelial cells (UCs) and smooth muscle cells (SMCs) was tested. (biomedcentral.com)
In addition, the urethral caliber, speed of urothelial regeneration, content of smooth muscle, and vessel density were significantly improved in the group with autologous USC-seeded SIS. (biomedcentral.com)
Moreover, inflammatory cell infiltration and fibrosis were found in the control group with only SIS, but not in the experimental autologous USC-seeded SIS group. (biomedcentral.com)
Autologous USCs can be used as an alternative cell source for cell-based tissue engineering for urethral reconstruction. (biomedcentral.com)
In addition, autologous CSCs can be employed without the ethical and immunological problems associated with the use of embryonic stem cells. (derstandard.at)
Aspen is the only company taking an autologous approach to cell therapy for Parkinson's disease. (blogspot.com)
Today, Aspen Neuroscience announced its official launch with $6.5 million seed financing to develop the first autologous cell therapies for Parkinson's disease. (techstartups.com)
Aspen then differentiates the pluripotent stem cells into dopamine-releasing neurons that can be transplanted into that same person (autologous), thereby restoring the types of neurons lost in Parkinson's disease. (techstartups.com)
As an autologous cell therapy for Parkinson's disease, Aspen's treatment would eliminate the need for immunosuppression because the neurons are transplanted back into the same patient from which they were generated. (techstartups.com)

The mesh acted as a scaffold on which the stems cells were grown into morphologically recognizable cardiac tissue. (derstandard.at)
We then joined the cardiac tissue built from the mesh scaffold onto the diseased structure of the heart to stimulate the regeneration of the optimal cell types for that particular portion of the heart. (derstandard.at)
Cell sheet-based scaffold-free technology holds promise for tissue engineering applications and has been extensively explored during the past decades. (researchgate.net)
Basement membrane proteins modulate cell migration on bovine pericardium extracellular matrix scaffold. (mayo.edu)
The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)

Specifically, the lab is developing a multifunctional biodegradable conduit that can be seeded with adult stem cells to facilitate nerve regeneration. (moleculardevices.com)
This means that CSCs represent a logical source for cardiac regeneration therapy because, unlike other adult stem cells, they are intrinsically programmed to generate cardiac tissue in the lab and thus increase cardiac tissue viability in humans. (derstandard.at)
5] Schmalenberg K E, Uhrich K E. Micropatterned polymer substrates control alignment of proliferating Schwann cells to direct neuronal regeneration[J]. Biomaterials, 2005, 26(12):1423-1430. (sdu.edu.cn)
9] Alessandri G, Emanueli C, Madeddu P. Genetically engineered stem cell therapy for tissue regeneration[J]. Ann N Y Acad Sci, 2004, 1015:271-284. (sdu.edu.cn)
On the one hand, this (sterile) neuroinflammation eliminates degenerating tissue, thus supporting a restorative milieu for neuroprotection, axonal regeneration, remyelination, and stem cell-mediated tissue repair. (biomedcentral.com)
There are limited numbers of publications about ES cells in pulp regeneration, due to the restricted policies regarding ES cell research over the past few years. (bvsalud.org)
About 650 publications in the fields of neuroanatomy, neuronal regeneration, cell transplantation and repair in the central nervous system. (lu.se)

Analyses of recovered implants revealed organized PDL tissues surrounding titanium implant surfaces in PDL-cell-seeded, and not in unseeded control, implants. (nih.gov)
These proof-of-principle findings suggest that PDL DPCs can organize periodontal tissues in the jaw, at the site of previously lost teeth, indicating that this method holds potential as an alternative approach to osseointegrated dental implants. (nih.gov)
Through medical research, stem cells can now be grown and transformed into a variety of specialised cells with characteristics consistent with tissues such as muscles or nerves. (derstandard.at)
Several technologies have been described over the past 10 years to create functional heart tissue by using stem cells that have been isolated from other tissues such as bone marrow, skeletal muscle, and umbilical cord blood. (derstandard.at)
These new transplantation systems enhance the viability of cells and stimulate their outward migration so that they can populate and help regenerate injured tissues. (derstandard.at)
In 2006, Takahashi and Yamanaka discovered that mature cells could be reprogrammed back into a pluripotent state, which introduced the option of using patient derived stem cells as a tool for engineering tissues [ 4 ]. (biomedcentral.com)
Organ-on-chips are miniaturized devices that arrange living cells to simulate functional subunits of tissues and organs. (selectbiosciences.com)
An analysis of 31 tissues finds that random mutations acquired during stem cell divisions correlate with lifetime cancer risk. (the-scientist.com)
Moreover, the total numbers of cells that make up these tissues also cannot explain varying cancer risk. (the-scientist.com)
Colorectal and basal cell tissue have the highest number of cell divisions of the tissues analyzed and are also the most frequently observed cancer type. (the-scientist.com)
C. Tomasetti and B. Vogelstein, "Variation in cancer risk among tissues can be explained by the number of stem cell divisions," Science , doi:10.1126/science.1260825, 2014. (the-scientist.com)
Wounds are living environments and the conditions change quickly as cells and tissues communicate and attempt to repair. (sociable.co)
In a study published in November in Cell Reports Methods , researchers from Tokyo Medical and Dental University (TMDU) reveal that applying a few specialized lab techniques yields intestine-like tissues of predictable size and composition. (sciencedaily.com)
Given that more complex intestinal tissues have been generated using traditional techniques, it is likely that this new approach could be easily adapted to create more complex organoids, such as intestine-like tissue containing blood vessels or nerves. (sciencedaily.com)
This produces one to two days of expression which, by the sound of things, is enough to give telomeres enough of a boost in length to be worth the exercise, can be repeated as needed, is familiar to regulators, and the LNP field is energetically working towards variant LNPs that can target specific tissues and cell types. (fightaging.org)
All tissues originate from stem cells. (bvsalud.org)
A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)
Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)

Prominent TE studies using this approach rely on materials such as porcine small intestinal submucosa (SIS) or decellularized tendon. (researchgate.net)

Stem cells are characterised by their unique ability to constantly renew themselves and differentiate into a diverse range of other specialised cell types. (derstandard.at)
Pluripotent stem cells can differentiate into any cell type found in an organism, making them a valuable tool for tissue engineering [ 1 - 3 ]. (biomedcentral.com)
For example, we anticipate interventions that modulate immune response, recruit necessary cell types to the wound, or direct how stem cells differentiate to expedite healing," he added. (sociable.co)

Accordingly, researchers at this institution were quick to appreciate the enormous promise of human embryonic stem cells (hESCs) as research tools for understanding how the body normally works, thus laying the groundwork to identify disease-related aberrations. (ca.gov)
By voting in favor of Proposition 71, which funds research involving human embryonic stem cells (hESCs) that is not supported by the federal government, the citizens of California sent a clear message that they want scientists in our state to play an important role in research that could revolutionize medical treatments and render significant economic benefits. (ca.gov)
Based on their origin, there are two main types of stem cells - embryonic stem cells (ES cells) and postnatal or adult stem cells (AS cells). (bvsalud.org)
Embryonic stem cells are stem cells derived from the inner cell mass of an early, preimplantation stage embryo known as a blastocyst. (bvsalud.org)

The MSCs were isolated from the fat of Crohn's patients, expanded, and seeded onto the fistula plug. (scienceboard.net)

Using mice models, researchers from Japan and China have shown that dendritic cell immunoreceptor (DCIR) protein deficiency is resistant to colonic tumors. (scienceboard.net)
BCSCs can develop into many cell types and repopulate heterogeneous tumors following conventional chemotherapy or radiotherapy [ 4 , 6 ]. (hindawi.com)
In the study he and his colleagues showed that stem cells can be directed by the body to form bone in laboratory mice, and, under the appropriate guidance, are much less likely to become dangerous tumors called teratomas. (stanford.edu)
A mouse model of glioblastoma, an aggressive type of cancer that can occur in the brain, suggests that this recalcitrant cancer originates from a pool of stem cells that can be a significant distance away from the resulting tumors. (sciencedaily.com)
However, some recent research in glioblastoma patients shows that the subventricular zone (SVZ) -- an area that serves as the largest source of stem cells in the adult brain -- contains cells with cancer-driving mutations that are shared with tumors found in other often far-distant brain regions. (sciencedaily.com)
Starting from about 5.5 months old, these animals received weekly brain scans to look for tumors that arise when the stem cells subsequently acquire more mutations. (sciencedaily.com)
Using genetic tests and an approach akin to those used to study evolution, the researchers traced the cells that spurred both kinds of tumors back to the SVZ. (sciencedaily.com)
Although both single and multiple tumors had spontaneously acquired mutations in a gene called Pten, another type of tumor suppressor, precursor cells for the single tumors appeared to acquire this mutation before they left the SVZ, while precursor cells for the multiple tumors developed this mutation after they left the stem cell niche. (sciencedaily.com)
If new glioblastoma tumors are seeded by cells from a repository in the SVZ, he explains, attacking those tumors won't be enough to eradicate the cancer. (sciencedaily.com)

They closely interact with endogenous neural stem cells (NSCs) residing in distinct niches of the adult brain. (biomedcentral.com)

Using a hybrid therapy that incorporates tissue engineering, we seeded a biodegradable mesh with cardiac stem cells. (derstandard.at)

Shklover J, McMasters J, Alfonso-Garcia A, Higuita ML, Panitch A, Marcu L, Griffiths L . Bovine pericardial extracellular matrix niche modulates human aortic endothelial cell phenotype and function. (mayo.edu)

Mechanistically, the importance and meaning of these observations needs to be addressed in a suitable and easily manipulable in vitro system consisting of human islets and immune cells. (selectbiosciences.com)
Although other irritants in the smoke may have contributed to the incident, there is supporting evidence that stable strontium can stimulate the release of histamine from mast cells in vitro (ATSDR 2001e). (cdc.gov)

But we realized that cell transplantation may not always be suitable for catastrophic events, such as a heart attack in which there is major myocardial damage. (derstandard.at)
Currently, these treatments largely consist of surgical or pharmacological interventions, and transplantation approaches that involve significant hurdles. (ca.gov)
Finally, there are major shortages of cells and organs for use in transplantation procedures. (ca.gov)
Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse[J]. J Exp Med, 2005, 201(9):1397-1405. (sdu.edu.cn)
Co-transplantation of neural stem cells and NT-3-overexpressing Schwann cells in transected spinal cord[J]. J Neurotrauma, 2007, 24(12):1863-1877. (sdu.edu.cn)
And my specialties are in blood cancers, and stem cell transplantation, and cell therapy. (kickingabs.com)

Objective To investigate cytocompatibility of the electron spinning chitosan-PLGA nerve conduits with Schwann cells (SCs)and neural stem cells(NSCs) as well as cells adhesion and migration on the arranged nanofibers inside the lumen. (sdu.edu.cn)
Cytocompatibility research of schwann cells and neural stem cells co-seeded on electron spinning chitosan-PLGA[J].JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(3): 16-19. (sdu.edu.cn)

His research interests include imaging informatics, artificial intelligence and machine learning, telemedicine, cell-based therapies and clinical trial design. (stanford.edu)
March 3, 2023 -- Most Crohn's disease patients experienced complete clinical healing of perianal fistulas after treatment with a stem cell-loaded plug, according to data published in the journal Diseases of the Colon & Rectum . (scienceboard.net)
In a phase I clinical trial, the researchers studied the approach in 20 adults with complex single-tract Crohn's perianal fistulas who had not responded to conventional therapy. (scienceboard.net)
Breast cancer stem cells (BCSCs) are one of the main factors driving chemoresistance, thereby contributing to poor prognosis and clinical outcomes [ 3 - 5 ]. (hindawi.com)
METHODS: The discovery-validation approach was planned incorporating a series of G-CIMP-/unMGMT GBM cohorts with DNA methylation microarray data and clinical information, to construct multi-CpG prediction models. (bvsalud.org)
Overall primary concerns are: extrapolating human clinical studies, seeding durable effective T cell resident memory (Trm), population human leucocyte antigen (HLA) coverage, and the potential for T cell-mediated immune escape. (mdpi.com)
Our customers mainly work in stem cell expansion areas, such as cell banking and cell production for clinical applications. (integra-biosciences.com)
We want to provide these scientists with solutions that enable them to expand their stem cell lines and harvest sufficient volumes of cells for wider clinical applications and, ultimately, treatments. (integra-biosciences.com)
Dr. Wirth currently serves as the Chief Medical Ofﬁcer for Lineage Cell Therapeutics where he oversees clinical development of its two therapeutic programs for spinal cord injuries and lung cancer. (techstartups.com)

This study aimed to explore the potential targets and molecular mechanisms of HNK on metastatic BCSC (mBCSC)-cell cycle arrest and the impact of the TME. (hindawi.com)

The awards, which include $1.5 million in seed funding for each recipient, recognize early career scientists whose innovative research has the potential to lead to improved therapies. (stanford.edu)
Stem cell therapies already exist in medical practice. (derstandard.at)
The approach can avoid the immunosuppression necessary for allogeneic therapies. (blogspot.com)
I worked very closely with Dr. Bishop since he arrived, using a lot of the new therapies that are effective for this particular disease, including immunotherapy, stem cell transplant. (kickingabs.com)
Aspen Neuroscience is a development stage, private biotechnology company that uses innovative genomic approaches combined with stem cell biology to deliver patient-specific, restorative cell therapies that modify the course of Parkinson's disease. (techstartups.com)
The use of immunosuppression is necessary with currently available cell therapies for Parkinson's disease and when transplanting cells from one patient to another (allogeneic) to prevent rejection but can pre-dispose the patient to life-threatening complications including infection and add cost to the patient and health system. (techstartups.com)
This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)

These cells were termed induced pluripotent stem cells (iPSCs). (biomedcentral.com)
Aspen is built on Loring's research at the Scripps Research Institute and the PluriTest , an assay she developed after discovering that pluripotent cells have a distinct genetic signature. (blogspot.com)
There are established methods for growing human intestinal organoids (HIOs) from induced pluripotent stem cells (iPSCs)," states Junichi Takahashi, first author of the study. (sciencedaily.com)
Aspen is focusing on human pluripotent stem cells, cultured cells that can become any cell type in the human body. (techstartups.com)
The company's research is specific to induced pluripotent stem cells (iPSCs), which it develops by taking a skin biopsy from a person with Parkinson's disease and turning the tissue into pluripotent stem cells using genetic engineering. (techstartups.com)
ES cells are pluripotent cells, which mean that they can give rise to all differentiated cell types derived from all three germ layers. (bvsalud.org)

The UWM team found that if they strip away all the plant's cells and chemically treat the left-over cellulose, human stem cells such as fibroblasts are very eager to take up residence in the husks. (zmescience.com)

In contrast, bone tissue of the pelvis, head and arms undergoes the lowest number of stem cell divisions and has among the lowest observed cancer rates. (the-scientist.com)
Early successes demonstrated the potential for the therapy, as bone marrow stem cells navigated to the implanted thymus tissue to develop into T cells. (news-medical.net)
43 Therefore, cell sheets with enhanced thickness and mechanical properties obtained through appropriate cyclic mechanical stimulation possess great potential for bone tissue engineering applications. (researchgate.net)
After implantation into the critical-sized calvarial defects of mice, the mechanically conditioned cell sheets significantly promoted new bone formation. (researchgate.net)
Findings from this study reveal that thermo-responsive elastomer, together with mechanical conditioning, can potentially be applied to prepare high-quality cell sheets for bone tissue engineering. (researchgate.net)
Her research interest focuses on understanding the effect of pathological microenvironments on cells, and specifically, bone cells to expand knowledge on bone fragility. (universityofgalway.ie)
First, within the group of Professor Laoise McNamara on a mechanobiological approach to treat osteoporosis and on several aspects of bone mechanobiology (engineering, metastasis, modeling, fragility). (universityofgalway.ie)
The effects of dynamic compression on the development of cartilage grafts engineered using bone marrow and infrapatellar fat pad derived stem cells. (qmul.ac.uk)

90% of cancer-related deaths, is a multi-step process involving cancer cell intravasation into the bloodstream, dissemination to distant sites, and seeding in new organs 1 . (nature.com)
Today, the regrowth of Prometheus' liver has become a symbol to medical researchers for the possible renewal of damaged human organs through the use of human stem cells. (derstandard.at)
Researchers from Japan have developed a new approach that enables intestinal mini-organs to be grown more easily and efficiently in the lab. (sciencedaily.com)

This disease process is driven by a reduction in the number of oligodendrocyte progenitor cells (OPCs) that can result from postnatal infections that induce systemic inflammation, including necrotizing enterocolitis or spontaneous intestinal perforations. (tellustherapeutics.com)

Protein kinase C iota (PKCι), a serine/threonine kinase required for cell polarity, proliferation and migration, is commonly up- or downregulated in cancer. (qmul.ac.uk)

A San Diego firm that has $22 million worth of financial roots in the California stem cell agency this month snagged a bonus -- a ton of favorable attention for its efforts to treat Parkinson's disease. (blogspot.com)
Parkinson's disease is characterized by the loss of specific brain cells that make the chemical dopamine. (techstartups.com)
At the forefront is Aspen Neuroscience , a healthtech startup developing first-of-its-kind personalized cell therapy for Parkinson's disease. (techstartups.com)
The company was initially supported by Summit for Stem Cell, a founding partner and non-profit organization which provides a variety of services for people with Parkinson's disease. (techstartups.com)

Now researchers have developed a new kind of biological sutures, made from polymer strands infused with stem cells, that might help surmount two major obstacles to using stem cells to heal the heart: getting the cells to the right spot and keeping them there long enough to trigger healing. (technologyreview.com)
Researchers have identified two therapeutic approaches that could treat multiple forms of amyotrophic lateral sclerosis (ALS), raising hope that it may. (scienceboard.net)
But medical researchers hope to be able to use technologies derived from stem cell research to treat a much wider variety of diseases. (derstandard.at)
The patented test shows whether a cell has achieved pluripotency, which allows researchers to avoid conducting more time-consuming confirmatory tests. (blogspot.com)
Longaker and his collaborators hope that, rather than directing the cells to assume a certain developmental fate in the laboratory, researchers could perhaps use them in their undifferentiated state. (stanford.edu)
Our work is important because the researchers who use our laboratory are studying the causes of major human diseases that occur as the result of trauma (e.g., paralysis), cell death (e.g. (ca.gov)
With the advent of hESCs, researchers are envisioning new therapeutic approaches. (ca.gov)
To develop a more robust and consistent way to generate HIOs, the researchers explored the use of cell culture plates made with an ultra-low attachment polymer to encourage the cells to detach and grow in suspension. (sciencedaily.com)
When the researchers genetically altered the animals to shut down the molecular pathway that loss of Pten activates, it didn't stop cancer cells from forming. (sciencedaily.com)
The screenMATRIX is the starting product for many researchers when they begin a new project, as it helps them to discover the optimal growth conditions for their cells. (integra-biosciences.com)

However, efficient harvest and handling of cell sheets remain challenging, including insufficient extracellular matrix content and poor mechanical strength. (researchgate.net)
Mechanical loading has been widely used to enhance extracellular matrix production in a variety of cell types. (researchgate.net)
We found that the extracellular matrix content and thickness of cell sheet were markedly elevated upon appropriate mechanical conditioning. (researchgate.net)

Just as the shape of water is determined by its container, cells respond to external cues. (stanford.edu)

The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
Finally, the interaction between HNK and two HNK-targets regulating the cell cycle was analyzed using molecular docking analysis. (hindawi.com)
The identified potential therapeutic targets of HNK (PTTH) included CCND1 , SIRT2 , AURKB , VEGFA , HDAC1 , CASP9 , HSP90AA1 , and HSP90AB1 , which can potentially inhibit the cell cycle of mBCSCs. (hindawi.com)
So we take a portion of the monoclonal antibody, which targets the cancer, and then we take a portion of an immune cell call a T-cell, and we use its receptor. (kickingabs.com)
And once it expresses that, it targets the cancer cell. (kickingabs.com)

BCSCs are mostly dormant, and therefore, activating them and modulating the cell cycle are important for successful therapy against BCSCs. (hindawi.com)
Chemoresistance, or the insensitivity of cancer cells to drug therapy, is a major factor in the failure of chemotherapy against breast cancer. (hindawi.com)
OK, so a CAR T-cell therapy, comes back to that Trojan horse analogy. (kickingabs.com)
So with CAR T-cell therapy, CAR stands for chimerical antigen receptor. (kickingabs.com)
And what we do in CAR T-cell therapy is take different components. (kickingabs.com)

To date, four types of human dental stem cells have been isolated and characterized: (i) dental pulp stem cells (DPSCs) 12 (ii) stem cells from exfoliated deciduous teeth (SHED) 21 (iii) stem cells from apical papilla (SCAP) 31 (iv) periodontal ligament stem cells (PDLSCs) 28 . (bvsalud.org)

But stem cells are longer-lived, self-renew, and give rise to clonal cell populations within a tissue. (the-scientist.com)

The research is also part of a larger trend to combine stem cells with tissue engineering and novel biomaterials to help cells grow more naturally and to improve their survival rate once implanted. (technologyreview.com)
Tissue engineering combines biomaterials and cells, creating functional structures that can replace damaged regions of tissue [ 1 , 2 ]. (biomedcentral.com)
Biomaterials are a vital tool for many areas of stem and primary cell research, but reproducibly recreating complex human biology under lab conditions can be difficult. (integra-biosciences.com)

These studies have led to several findings, for example that certain cytokines are generated by beta cells themselves, sometimes under stress, and also that there are probably key factors that render beta cells susceptible to immune attacks. (selectbiosciences.com)
Evidence from animal models shows that T cells can provide heterosubtypic protection and are crucial for immune control of influenza virus infections. (mdpi.com)
The problem is, how do you get that chimera into the immune cell that you want to use for treatment. (kickingabs.com)
Within the central nervous system (CNS), microglia are the resident immune cells that mediate and regulate inflammatory processes. (biomedcentral.com)
To date, various genome-scale loss-of-function screening methods have been developed, including approaches employing RNA interference 1 , 2 and the RNA-guided endonuclease Cas9 from the microbial CRISPR (clustered regularly interspaced short palindromic repeat) adaptive immune system 3 , 4 . (cdc.gov)

Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)
CSCs display the slow-migratory, invadopod-rich phenotype that is the hallmark of disseminating tumor cells. (nature.com)
At the apex of the hierarchy are the cancer stem cells (CSCs). (nature.com)

But the benefits using these types of stem cells have ranged from marginal, to transient, to nil. (derstandard.at)

Research in the Sakaguchi Lab at Iowa State University focuses on experimental strategies for the rescue and repair of the damaged nervous system using stem cell approaches. (moleculardevices.com)
According to DARPA, although recent experimental treatments offer some hope for expedited recovery, many of these new approaches remain static in nature. (sociable.co)
Considering the past, and reviewing the milestones of every scientific finding could help in molding future experimental approaches in cancer research. (jcancer.org)

60% of circulating tumor cells. (nature.com)
Macrophages are emerging as major cellular factors in the tumor ecosystem that can influence the stem phenotype and cancer progression. (nature.com)
Furthermore, macrophages were shown to contribute to a niche that can support and maintain a breast CSC (BCSC) phenotype through heterotypic CD90/EphA4 signaling between macrophage and tumor cell 14 . (nature.com)
Most fully differentiated cells, even those that have accumulated mutations, do not seed a tumor because of their short lifespan. (the-scientist.com)
We examined the patients' background (tumor location, macroscopic type, tumor size, histological type, and depth of invasion) and treatment outcomes (procedure duration, en bloc resection rate, R0 resection rate, and adverse events). (bvsalud.org)

This is an out-of-the-box approach," says Charles Murry , a director of the Center for Cardiovascular Biology at the University of Washington, who was not involved in the study. (technologyreview.com)
She was awarded a PhD in Cell Biology - Bioengineering from the University of Lorraine, Nancy, France. (universityofgalway.ie)
Lund Stem Cell Center's Research School in Stem Cell Biology has a new Executive Coordinator, Mattias Magnusson. (lu.se)

These porous microstructures allow cell infiltration into the matrix and have fewer heterogeneous cellular proteins, thereby preventing complications, such as inflammatory reactions, fibrosis, calcification, and graft shrinkage. (biomedcentral.com)

The main indications for tracheal reconstruction include malignant tumours (squamous cell carcinoma, adenoid cystic carcinoma), tracheoesophageal fistula, trauma, unsuccessful surgical results for benign diseases and congenital stenosis. (ersjournals.com)
Tracheal reconstruction and replacement is a complex and vital surgical procedure with several indications, including primary tracheal neoplasm (adenoid cystic carcinoma and squamous cell carcinoma), thyroid cancer, extensive tracheoesophageal fistulas, unsuccessful previous surgery for benign tracheal diseases (re-stenosis, long-term stenosis that has been dilated or been non-surgically repaired) and, rarely, congenital tracheal stenosis. (ersjournals.com)
Once populated by cells, the suture is attached to a surgical needle. (technologyreview.com)
He specializes in voice, breathing and swallowing problems in pediatric patients, including surgical management of dysphagia and approaches for managing chronic cough. (stanford.edu)
Although ESD for lesions at anastomotic sites is a technically challenging procedure because of severe submucosal fibrosis, this approach could prevent the need for repeated surgical resection. (bvsalud.org)
A complete understanding of the surgical and interventional approach to the liver requires a comprehensive understanding of its anatomy and vascular supply. (medscape.com)

Tissue engineers are developing a number of different methods for delivering stem cells to a wounded heart, including growing patches of beating heart muscle. (technologyreview.com)
We used those funds to develop our genomics tools and databases and to develop improved methods for handling the cells. (blogspot.com)

Since UCSF contributed two hESC lines to the federal registry, our team members participated in the government's program to distribute these cells, which entailed teaching scientists how to use them. (ca.gov)

is known to exert anticancer effects, such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. (hindawi.com)
And there is a ton of different types of immunotherapy, whether it's designing antibodies that attack proteins that live on the surface of cells, or putting those antibodies together with a payload, almost like a Trojan horse. (kickingabs.com)

Results Cell survival rate of the co-culture group was the highest, the higher in the SCs group, and the lowest in the NSCs group. (sdu.edu.cn)
Conclusion Co-culture of SCs and NSCs can facilitate cells compatibility and adhesion with 3D Chitosan-PLGA, and the axial arranged nanofibers within the lumen has the effect of directional guide cell growth and migration. (sdu.edu.cn)

The possible donor-host rejection of human ES cells is another concern 3 . (bvsalud.org)

We are thrilled to have Xontogeny as a collaborative partner and appreciate their seed investment to develop a pipeline of products with the potential to improve care, outcomes and lives of patients and their families," said Jason Kralic, President and Chief Executive Officer, Tellus Therapeutics. (tellustherapeutics.com)

In a resting state, microglia are involved in the maintenance of cell homeostasis surveying their microenvironment and communicating with the neuronal tissue via extremely motile processes and protrusions [ 8 ]. (biomedcentral.com)

In the video above, Michael Longaker , MD, a Stanford stem cell scientist and pediatric plastic and reconstructive surgeon, discusses fascinating new research appearing today in the Proceedings of the National Academy of Science . (stanford.edu)
Vascular reconstruction in pediatric patients requires a substantially different approach from that used in adults. (medscape.com)

Pasca , assistant professor of psychiatry and behavioral sciences, and Scherrer , assistant professor of anesthesiology, perioperative and pain medicine and of neurosurgery, were named 2017 New York Stem Cell Foundation Robertson Investigators. (stanford.edu)

Stem cells are sensitive to topography. (zmescience.com)

check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

Anatomy57

Organisms16

Diseases12

Chemicals and Drugs67

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Phenomena and Processes51

Disciplines and Occupations4

Technology, Industry, Agriculture2

Information Science2

Named Groups1

Health Care1

Mesenchymal16

Scaffolds15

Differentiation10

Regenerative14

Autologous12

Scaffold5

Regeneration7

Tissues18

Small intestina1

Differentiate3

Embryonic4

MSCs1

Tumors9

Adult1

Biodegradable1

Endothelial1

Vitro2

Transplantation6

Neural2

Clinical9

Metastatic1

Therapies7

Pluripotent6

Fibroblasts1

Bone8

Organs3

Progenitor cells1

Proliferation1

Parkinson's4

Researchers10

Extracellular matrix3

Cues1

Targets5

Therapy5

Periodontal1

Populations1

Biomaterials3

Immune5

CSCs3

Types of stem cells1

Experimental3

Tumor5

Biology3

Inflammatory1

Surgical6

Methods2

HESC1

Immunotherapy2

NSCs2

Rejection1

Outcomes1

Microenvironment1

Pediatric2

20171

Topography1

Stomata1