AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Lung NeoplasmsSarcoma, Clear CellCarcinoma, Non-Small-Cell LungCarcinoma, Small CellSmall Cell Lung CarcinomaLangerhans Cell SarcomaCarcinoma, Large CellSarcomaSarcoma, Small CellDendritic Cell Sarcoma, FollicularCarcinoma, Squamous CellDendritic Cell Sarcoma, InterdigitatingAdenocarcinomaNeoplasm StagingAntineoplastic AgentsCell Line, TumorPrognosisReceptor, Epidermal Growth FactorQuinazolinesImmunohistochemistrySarcoma, SynovialCarcinomaAntineoplastic Combined Chemotherapy ProtocolsSurvival RateLungHistiocytic SarcomaSoft Tissue NeoplasmsSarcoma, EwingSarcoma, ExperimentalSarcoma, KaposiCarcinoma, HepatocellularTumor Cells, CulturedTumor Markers, BiologicalAvian Sarcoma VirusesGastrin-Releasing PeptideSarcoma 180Gene Expression Regulation, NeoplasticEtoposideOncogene Proteins, FusionCarcinoma, NeuroendocrineDendritic Cells, FollicularLung DiseasesPhosphopyruvate HydrataseLiver NeoplasmsNephroma, MesoblasticCarcinoma in SituNeoplasm MetastasisFatal OutcomeLymphoma, Non-HodgkinNeoplasm TransplantationTreatment OutcomeBombesinCisplatinSarcoma Viruses, MurineMice, NudeParaneoplastic SyndromesReverse Transcriptase Polymerase Chain ReactionAntigens, NeoplasmLeiomyosarcomaNeoplasm Recurrence, LocalDNA, NeoplasmCarcinoma, PapillaryCarcinoma, BronchogenicRNA-Binding Protein EWSTomography, X-Ray ComputedLymphoma, Large B-Cell, DiffuseReceptors, BombesinCombined Modality TherapyPeripheral Nervous System NeoplasmsRetrospective StudiesSurvival AnalysisRNA, MessengerNeoplasm ProteinsAntibodies, MonoclonalCell TransdifferentiationCell DivisionChromosomes, Human, Pair 3In Situ Hybridization, FluorescenceSkin NeoplasmsSarcoma, AvianTopotecanEye NeoplasmsBase SequenceBiopsyCarcinoma, Ductal, BreastImmunoenzyme TechniquesNeoplasm InvasivenessTransplantation, HeterologousCarcinoma, Basal CellDrug Resistance, NeoplasmKidney NeoplasmsApoptosisCell LineMelanomaLung InjuryPneumonectomyLymphatic MetastasisCell ProliferationMast-Cell SarcomaWilms Tumor
MelanomaTumorsMerkel Cell CarcHepatocellularNSCLCAdenocarcinomaSecretory carcinoma of the salivaryCancersLymphomaAIDS-related Kaposi'sTumor typesMalignantMetastaticProstateLiposarcomaPapillarySalivaryChemotherapyGastricSituSolitary fibrous tumorSCLCFibrousSubtypesSquamous cellEwing'sSynovialPrimaryMetastasesTissuesProliferationSoft-tissueIntestineOvary2022KidneyCancer cellsVascular
Melanoma3
  • This study will investigate the safety and tolerability of MAGE-A4ᶜ¹º³²T cell therapy in subjects who have the appropriate HLA-A2 tissue marker and whose urinary bladder, melanoma, head and neck, ovarian, non-small cell lung, esophageal, gastric, synovial sarcoma, or myxoid/round call liposarcoma (MRCLS) tumor has the MAGE-A4 protein expressed. (mycancergenome.org)
  • This link is explored for the most common cancer types - lung, breast, and melanoma. (elsevier.com)
  • The most common malignancies that develop in carriers of BAP1 germline mutations include diffuse malignant mesothelioma, uveal and cutaneous melanoma, renal cell carcinoma, and less frequently, breast cancer, several types of skin carcinomas, and other tumor types. (bvsalud.org)
Tumors21
  • This is a First-in-Human Phase IA/IB/II open label dose escalation study of intravenous (IV) administration of ONC-392, a humanized anti-CTLA4 IgG1 monoclonal antibody, as single agent and in combination with pembrolizumab in participants with advanced or metastatic solid tumors and non-small cell lung cancers. (fredhutch.org)
  • This study will take a subject's T cells and give them a T cell receptor protein that recognizes and attacks the tumors. (mycancergenome.org)
  • It is now accepted that the formation of solid tumors requires the proliferation of stromal cells to support cancer cell growth, invasion, and metastasis [ 5 ] and that the stromal cell compartment comprises a heterogeneous mix of cell types responsible for the formation of blood vessels as well as supporting a microenvironment commensurate with tumor growth and proliferation. (hindawi.com)
  • by then, she was in a wheelchair and relied on supplemental oxygen to breathe because tumors filled 90% of her lungs. (curetoday.com)
  • However, little is known about the mechanisms underlying the activation of this proto-oncogene in tumors. (biomedcentral.com)
  • However, little is known about the molecular mechanisms underlying the aberrant activation of FLI1 in these solid tumors. (biomedcentral.com)
  • No. 4,975,278) allows targeted delivery of the drug moiety to tumors, and intracellular accumulation therein, where systemic administration of these unconjugated drug agents may result in unacceptable levels of toxicity to normal cells as well as the tumor cells sought to be eliminated (Baldwin et al (1986) Lancet pp. (justia.com)
  • These cells may form tumors, which are lumps of tissue. (cancer.gov)
  • This system is based on defining the characteristics of the primary tumor (T), regional lymph node involvement (N), and the presence of distant metastases (M). The revisions in the new seventh edition of TNM staging were proposed by the International Association for the Study of Lung Cancer (IASLC) staging project for lung tumors. (medscape.com)
  • However, the new classification applies to small cell lung carcinoma (SCLC) and bronchopulmonary carcinoid tumors as well. (medscape.com)
  • The new system is not used to stage sarcomas or other rare tumors. (medscape.com)
  • A chart summarizing the 2009 tumor, node, metastasis (TNM) staging system of lung tumors. (medscape.com)
  • Two illustrations summarizing the 2009 tumor, node, metastasis (TNM) staging system of lung tumors. (medscape.com)
  • Note that N1, N2, N3, and the separate tumor nodule of M1a were depicted in the lower illustration based on a right-sided tumor (T). For left lung tumors, a mirror image of these descriptors should be used. (medscape.com)
  • These tumors can pop up in neuroendocrine cells anywhere in the body. (webmd.com)
  • Rarely, tumors grow inside neuroendocrine cells of the prostate. (webmd.com)
  • Cancer Research UK: "Types of Prostate Cancer," "Small cell prostate cancer," "What are neuroendocrine tumors? (webmd.com)
  • The surgeon removes part of the lung where tumors are present. (mesolawsuitafterdeath.com)
  • Lung cancer is the formation and abnormal growth of cancer tumors in the lining of the bronchial tubes. (naturalhealingguides.com)
  • It is also used to treat sarcomas, lymphomas, and germ cell tumors. (advacarepharma.com)
  • MCPyV in tumor cell genomes, tumor-associated mutations search Ethics Board, Halifax, Nova Scotia, Canada, and in the large T-antigen (T-ag) gene, and large T-ag expres- by the Baylor College of Medicine Institutional Review sion in tumors suggest that MCPyV is not only associated Board, Houston. (cdc.gov)
Merkel Cell Carc1
  • Merkel cell carcinoma (MCC), an uncommon but aggressive form of skin cancer. (cdc.gov)
Hepatocellular4
  • Thermal ablation has proven beneficial for hepatocellular carcinoma and possibly for colorectal liver metastases, but data is lacking for other liver metastases. (nature.com)
  • MWA is well recognized for hepatocellular carcinoma (HCC), where it has been shown to be a safe, effective and minimally-invasive treatment option, that can be repeated in case of local recurrence 3 . (nature.com)
  • It was also under development for the treatment of metastatic pancreatic adenocarcinoma, gastric cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma. (globaldata.com)
  • Cabometyx (cabozantinib) developed for the treatment of patients with advanced renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). (pharmaceutical-technology.com)
NSCLC7
Adenocarcinoma5
Secretory carcinoma of the salivary1
  • These patients have five different tumor types: sarcoma, papillary thyroid cancer, mammary analog secretory carcinoma of the salivary glands, non-small cell lung cancer, and gastrointestinal stromal tumor. (ascopost.com)
Cancers10
  • NTRK fusions appear in some common cancers, such as non-small cell lung, sarcoma and colon, as well as some rare cancers, including secretary breast carcinoma and cellular or mixed congenital mesoblastic nephroma. (curetoday.com)
  • Common examples include prostate, breast, and lung cancers. (amazingposting.com)
  • Sarcomas are a rare group of cancers arising from connective tissues like bones, muscles, and blood vessels. (amazingposting.com)
  • These cancers start in the gland cells of the prostate. (webmd.com)
  • Small-cell carcinomas make up about 1% of prostate cancers. (webmd.com)
  • Mesothelioma and non-small cell lung cancer are cancers but are distinctly different. (mesolawsuitafterdeath.com)
  • Approximately 85% of lung cancers are non-small cell variety. (mesolawsuitafterdeath.com)
  • This type of non-small cell lung cancer accounts for 30% of lung cancers. (mesolawsuitafterdeath.com)
  • Almost all bladder cancers originate in the urothelium, which is a 3- to 7-cell mucosal layer within the muscular bladder. (medscape.com)
  • Hematopoietic Stem Cell Transplantation Hematopoietic stem cell (HSC) transplantation is a rapidly evolving technique that offers a potential cure for hematologic cancers ( leukemias, lymphomas, myeloma) and other hematologic disorders. (msdmanuals.com)
Lymphoma4
  • Tumor testing without cancer consultation - Advanced molecular testing through our UCHealth partner laboratory, Colorado Molecular Correlates (CMOCO), can determine if a lung tumor is positive for a variety of gene problems, including ALK (anaplastic lymphoma kinase). (uchealth.org)
  • Overexpression of FLI1 in erythroblasts causes inhibition of differentiation and ultimately the development of pre-T cell lymphoblastic leukemia/lymphoma [ 11 ]. (biomedcentral.com)
  • BK virus, simian munohistochemical testing showed that 1 T-cell lymphoma virus 40, and JC virus DNA sequences have been detected expressed MCPyV T-antigen. (cdc.gov)
  • The NHL samples were classifi ed as B- as previously described ( 20 ), omitting the deparaffi niza- cell lymphoma (n = 133), NK/T-cell lymphoma (n = 18), or tion step. (cdc.gov)
AIDS-related Kaposi's2
  • Ontaxel is indicated for the second line treatment of AIDS related Kaposi's Sarcoma. (drug-international.com)
  • For patients with AIDS-related Kaposi's sarcoma, paclitaxel injection administered at a dose of 135 mg/m² given intravenously over 3 hours every 3 weeks or at a dose of 100 mg/m² given intravenously over 3 hours every 2 weeks is recommended (dose intensity 45-50 mg/m²/week). (drug-international.com)
Tumor types1
  • Endosialin likely interacts with a network of extracellular and hypoxia activated proteins in sarcomas and other tumor types. (hindawi.com)
Malignant4
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. (medscape.com)
  • SWI/SNF‑related, matrix‑associated, actin‑dependent regulator of chromatin, subfamily a, member 4 (SMARCA4)‑deficient non‑small cell lung cancer (dNSCLC) is a rare malignant tumor that originates in the lungs. (spandidos-publications.com)
  • In this study, we investigated the presence of Merkel cell polyomavirus (MCPyV) was fi rst described MCPyV in benign lymph nodes and malignant lymphomas in 2008 ( 1 ) as a new human virus associated with in patients from Canada. (cdc.gov)
Metastatic2
  • Cabometyx is indicated as monotherapy for the treatment of adult patients with locally advanced or metastatic differentiated thyroid carcinoma (DTC), refractory or not eligible to radioactive iodine (RAI) who have progressed during or after prior systemic therapy. (pharmaceutical-technology.com)
  • Our case is among the first few in the literature on NTRK2 fusion sarcoma with first-line larotrectinib therapy in the primary and metastatic setting, with good clinical response and minimal side effects. (biomedcentral.com)
Prostate8
  • The different types of prostate cancer start in different cells. (webmd.com)
  • Doctors analyze your prostate tissue in a lab to see what kinds of cells have cancer in them. (webmd.com)
  • Gland cells make prostate fluid. (webmd.com)
  • It develops in the gland cells that line the prostate gland. (webmd.com)
  • This kind starts in the cells that line the ducts (or tubes) of the prostate gland. (webmd.com)
  • It develops in small round cells in the prostate and can spread very quickly. (webmd.com)
  • It starts in flat cells that cover the prostate. (webmd.com)
  • Small cell carcinoma of the prostate. (webmd.com)
Liposarcoma1
  • Within cohorts of soft tissue diagnoses assembled by tissue type (liposarcoma, leiomyosarcoma, undifferentiated sarcoma, and other), endosialin expression was significantly correlated with a better outcome. (hindawi.com)
Papillary1
Salivary2
Chemotherapy6
  • After Nichol Miller was diagnosed with a high-grade soft tissue sarcoma in her leg in the fall of 2014, she underwent broad-spectrum chemotherapy and surgery at Oregon Health and Science University Hospital, near her home in Portland. (curetoday.com)
  • Bone sarcomas such as osteosarcoma and chondrosarcoma are frequently refractory to conventional chemotherapy and radiotherapy that exhibit poor prognosis. (oncotarget.com)
  • Accumulated evidence suggests that bone sarcomas are highly resistant to chemotherapy and radiotherapy, and thus surgical resection is considered as the crucial treatment strategy [ 3 ]. (oncotarget.com)
  • Treatments involving chemotherapy, for example, to destroy cancer cells may also damage or destroy healthy cells in the body. (accuteach.com)
  • Major methods of treating lung cancer are by surgery, chemotherapy, and radiation. (naturalhealingguides.com)
  • Optimizing Chemotherapy of Pancreatic Acinar Cell Carcinoma: Our Experiences and Pooled Analysis of Literature. (cdc.gov)
Gastric1
Situ2
  • The invention also relates to methods of using antibodies and antibody-drug conjugate compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. (justia.com)
  • The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)
Solitary fibrous tumor1
  • Of note, the only other report in the literature on NRTK2 fusion-positive sarcoma also showed solitary fibrous tumor (SFT)-like morphology, and the patient responded well to larotrectinib as the second line adjuvant therapy. (biomedcentral.com)
SCLC3
Fibrous1
  • DSRCT is composed of small cells with round hyperchromatic nuclei and a dense fibrous or spindle cell stroma. (medscape.com)
Subtypes3
  • Our affiliate, the University of Colorado Cancer Center, serves as the lead site for the nationwide Lung Cancer Mutation Consortium-a collaboration of 14 of the nation's elite lung cancer programs-which offers free molecular tumor testing for certain subtypes of lung cancer. (uchealth.org)
  • The current case report further accentuates the intricate landscape of lung cancer subtypes and highlights the importance of a nuanced understanding of their molecular underpinnings to guide accurate diagnosis and tailored therapeutic approaches. (spandidos-publications.com)
  • In addition to GEP-NETs, there are several subtypes of NETs including pheochromocytoma, paraganglioma, medullary thyroid carcinoma, Markel cell carcinoma and bronchial carcinoids. (intheranostics.com)
Squamous cell4
  • Under a microscope, large cell carcinomas do not resemble adenocarcinomas or squamous cell carcinomas. (mesolawsuitafterdeath.com)
  • Other types include squamous cell carcinoma (see the image below) and adenocarcinomas. (medscape.com)
  • Cross-section through the bladder, uterus, and vagina with squamous cell carcinoma of the bladder infiltrating through the bladder wall into the vaginal wall. (medscape.com)
  • Global burden of HPV-attributable squamous cell carcinoma of the anus in 2020, according to sex and HIV status: A worldwide analysis. (who.int)
Ewing's1
  • As of 2016, experiments were under way for Neuroblastoma, Brainstem glioma, Ewing's sarcoma and Angelman's syndrome. (wikipedia.org)
Synovial5
  • The histogenesis of synovial sarcoma is unknown. (medscape.com)
  • Synovial sarcomas have been described in many anatomic sites. (medscape.com)
  • Overlapping lung and pleural involvement in individual cases has given rise to the more inclusive term "pleuropulmonary" synovial sarcoma. (medscape.com)
  • Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)
  • Does a Primary Brain Synovial Sarcoma Exist? (elsevier.com)
Primary2
  • [ 5 ] An earlier report, in 1956, by Babolini and Blasi, described the same clinicopathological entity using the nomenclature, "The pleural form of primary cancer of the lung. (medscape.com)
  • Osteosarcomas and chondrosarcomas are recognized as the most common primary bone sarcomas [ 1 ], which involve mesenchymal tissues and exhibit highly heterogeneous histologic and molecular profiles [ 2 ]. (oncotarget.com)
Metastases1
  • The Effect of the Kirsten Rat Sarcoma Viral Oncogene Homolog (Kras) Proto-Oncogene, GTPase Genetic Polymorphism on the Safety and Efficacy of Bevacizumab Combination Treatment Regimens for Patients with Nonsquamous, Non-Small Cell Lung Cancer with Brain Metastases. (cdc.gov)
Tissues5
  • These authors demonstrated monoclonal antibody FB5 reactivity in a significant proportion of tumor blood vessels, including those of sarcoma, while ostensibly being absent from normal tissues. (hindawi.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Carcinomas are the most common type of cancer, forming in the skin or tissues that line the internal organs. (amazingposting.com)
  • Cancer is a disease caused when cells divide uncontrollably and spread into surrounding tissues. (cancer.gov)
  • These fi ndings suggest that in human lymphoid tissues, blood cells, and lymphomas the lymphoid system plays a role in MCPyV infection and ( 17 - 20 ). (cdc.gov)
Proliferation4
  • Indeed, cell culture studies have demonstrated endosialin to be directly involved in regulating cellular proliferation [ 13 ] and in a subset of cells this proliferation appears to involve the PDGFR- β pathway [ 14 , 15 ]. (hindawi.com)
  • The Wnt signaling are evolutionarily conserved and implicated in cell proliferation and sarcomagenesis. (oncotarget.com)
  • Activation of Wnt/β-catenin signaling with Wnt3a or GSK-3β inhibitor drives the proliferation of bone sarcoma cells, whereas downregulation of activated Wnt signaling with dnTCF4 or siLEF1 suppresses bone sarcoma proliferation and induces cell cycle arrest. (oncotarget.com)
  • Taken together, our findings establish the evidence that aberrant activation of Wnt/β-catenin pathway involving an autocrine Wnt singaling drives the proliferation of bone sarcoma cells, and identify the autocrine activation of the Wnt/β-catenin signaling as a potential novel therapeutic target for bone sarcomas. (oncotarget.com)
Soft-tissue4
  • Monoclonal antibodies targeting endosialin have entered clinical trials, including soft tissue sarcomas. (hindawi.com)
  • We evaluated a cohort of 94 soft tissue sarcoma samples to assess the correlation between gene expression and protein expression by immunohistochemistry for endosialin and PDGFR- β , a reported interacting protein, across available diagnoses. (hindawi.com)
  • Since expression does vary across histologic groups, endosialin may represent a selective target in soft tissue sarcomas. (hindawi.com)
  • The results demonstrate the importance of the identification of NTRK alteration in soft tissue sarcoma, and the urgent need for mechanistic study for resistance to targeted therapy in NTRK2 fusion sarcoma. (biomedcentral.com)
Intestine1
  • Recipients of grafts containing immune cells (particularly bone marrow, intestine, and liver) are at risk of graft-vs-host disease, in which the donor immune cells attack recipient tissue. (msdmanuals.com)
Ovary2
  • Ontaxel is indicated as first line and subsequent therapy for the treatment of advanced carcinoma of the ovary.As first line therapy,Ontaxel is indicated in combination with cisplatin. (drug-international.com)
  • 1. For previously untreated patients with carcinoma of the ovary, one of the following recommended regimens may be given every 3 weeks. (drug-international.com)
20221
  • Epidemiology of Renal Cell Carcinoma: 2022 Update. (who.int)
Kidney2
  • A subtype that affects the kidneys, usually in the lining of tiny tubes in the kidney. (amazingposting.com)
  • Living donors are often used for kidney and hematopoietic stem cell transplants, less frequently for segmental liver transplants, and rarely for pancreas and lung transplants. (msdmanuals.com)
Cancer cells17
  • Using a CRISPR Cas9-guided immunoprecipitation assay, we identify a circular RNA in the FLI1 promoter chromatin complex, consisting of FLI1 exons 4-2-3, referred to as FECR1.Overexpression of FECR1 enhances invasiveness of MDA-MB231 breast cancer cells. (biomedcentral.com)
  • Using this CasIP assay, we identified FECR1, a FLI1 exonic circular RNA that binds to the FLI1 promoter and epigenetically activates FLI1 in breast cancer cells. (biomedcentral.com)
  • Transmembrane or otherwise tumor-associated polypeptides specifically expressed on the surface of cancer cells as compared to normal, non-cancerous cell(s) have been identified as cellular targets for cancer diagnosis and therapy with antibodies. (justia.com)
  • Identification of such tumor-associated cell surface antigen polypeptides, i.e. tumor associated antigens (TAA), allows specific targeting of cancer cells for destruction via antibody-based therapies. (justia.com)
  • Cancer cells differ from normal cells in many ways. (cancer.gov)
  • trick the immune system into helping cancer cells stay alive and grow. (cancer.gov)
  • For instance, some cancer cells convince immune cells to protect the tumor instead of attacking it. (cancer.gov)
  • Some cancer cells have double the normal number of chromosomes. (cancer.gov)
  • In addition, some cancer cells make energy from nutrients in a different way than most normal cells. (cancer.gov)
  • This lets cancer cells grow more quickly. (cancer.gov)
  • Many times, cancer cells rely so heavily on these abnormal behaviors that they can't survive without them. (cancer.gov)
  • Researchers have taken advantage of this fact, developing therapies that target the abnormal features of cancer cells. (cancer.gov)
  • Medicinal mushrooms contain several biologically active compounds that are effective against the development of cancer cells. (medicinenet.com)
  • Determination is decided by viewing the cancer cells under a microscope. (mesolawsuitafterdeath.com)
  • Furthermore, a study showed that the essential oil from the thyme plant has the potential of destroying certain cancer cells. (naturalhealingguides.com)
  • Asparagus root contains anti-cancer fighting agents that can prevent the growth and spread of lung cancer cells. (naturalhealingguides.com)
  • It works by slowing down or stopping the growth of cancer cells in the body. (advacarepharma.com)
Vascular1
  • Endosialin, also known as Tumor Endothelial Marker-1 (TEM-1) or CD248, was first described as a vascular endothelial cell surface antigen in human fetal fibroblasts [ 1 ]. (hindawi.com)