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  • Immunity
  • Placing regulatory T cells into global theories of immunity: an analysis of Cohn's challenge to integrity (Dembic). (semanticscholar.org)
  • The data are consistent with a role for PEPR1 as the receptor for At Pep1 to amplify innate immunity in response to pathogen attacks. (pnas.org)
  • Immunity is dependent upon activation of MHC class II-restricted T cells to an effector state capable of restricting growth and dissemination of the organisms. (jimmunol.org)
  • IL-12 ( 6 ), IFN-γ ( 7 , 8 ), and inducible (macrophage) nitric oxide synthase ( 9 ) are required for host immunity, perhaps reflecting activities mediated by CD40 ligand-CD40 interactions between T cells and APC ( 10 , 11 , 12 ). (jimmunol.org)
  • Coinfection with Heligmosomoides polygyrus fails to establish CD8+ T-cell immunity against Toxoplasma gondii. (nih.gov)
  • functional
  • The T cell antigen receptor (TCR) and pre-TCR complexes are composed of multiple signal-transducing subunits (CD3γ, CD3δ, CD3ε, and ζ) that each contain one or more copies of a semiconserved functional motif, the immunoreceptor tyrosine-based activation motif (ITAM). (rupress.org)
  • Here, we show that stimulatory or tolerogenic functional states of intracerebral DCs regulate the systemic activation of neuroantigen-specific T cells, the recruitment of these cells into the CNS and the onset and progression of experimental autoimmune encephalomyelitis (EAE). (jneurosci.org)
  • To reveal the functional characteristics of these spared cells, we generated a transgenic mouse expressing the TCR of a TRA-specific T cell that had escaped negative selection. (rupress.org)
  • effector
  • Although increased circulating tumor antigen-specific CD8 + T cells can be achieved by vaccination or adoptive transfer, tumor progression nonetheless often occurs through resistance to effector function. (aacrjournals.org)
  • Our results support interfering with PD-L1/PD-1 interactions to augment the effector function of tumor antigen-specific CD8 + T cells in the tumor microenvironment. (aacrjournals.org)
  • Some of these patients nonetheless had progressively growing melanoma, arguing that a relatively high frequency of specific effector T cells is not always sufficient for rejection of established metastatic cancer. (aacrjournals.org)
  • Eomesodermin (Eomes) is a member of the T-box family of transcription factors and plays critical roles in effector cell function and memory cell fitness of CD8 + T lymphocytes. (jimmunol.org)
  • These numerous experiments suggest that MHC class II-restricted Th1 effector cells and activated macrophages are necessary and sufficient for control of this intracellular infection. (jimmunol.org)
  • hematopoietic
  • Our laboratory is developing new approaches to enhance mucosal resistance in a variety of clinical circumstances where the intestinal microbiota is disturbed (e.g. following allogeneic hematopoietic stem cell transplantation). (mskcc.org)
  • dendritic cells
  • Dendritic cells (DCs) appear in higher numbers within the CNS as a consequence of inflammation associated with autoimmune disorders, such as multiple sclerosis, but the contribution of these cells to the outcome of disease is not yet clear. (jneurosci.org)
  • encodes
  • The labeled protein was purified to homogeneity, and its tryptic peptides were identified as gene At1g73080, which encodes a leucine-rich repeat receptor kinase, here called PEPR1. (pnas.org)
  • contrast
  • In contrast to high avidity cells, low avidity T cells persist in the antigen-positive periphery with no signs of anergy, unresponsiveness, or prior activation. (rupress.org)
  • inflammatory
  • 3. The effect of inflammatory cytokines on neural cell response was estimated by an in vitro culture system using embryonic mouse brain cells. (nii.ac.jp)
  • In addition, nitric oxide produced by inflammatory type NOS triggered apoptosis of neural cells in a p53-dependent manner. (nii.ac.jp)
  • chains
  • T helper cell recognition of idiotopes on λ2 light chains of M315 and%952: evidence for dependence on somatic mutation in the third hypervariable region. (springer.com)
  • transgene
  • Verification of the binding protein as the receptor for At Pep1 was established by demonstrating the loss of function of microsomal membranes of two SALK insertional mutants and by a gain in function of the alkalinization response to At Pep1 by tobacco suspension-cultured cells expressing the At1g73080 transgene. (pnas.org)
  • Onset
  • Intracerebral microinjection of stimulatory DCs exacerbated the onset and clinical course of EAE, accompanied with an early T-cell infiltration and a decreased proportion of regulatory FoxP3-expressing cells in the brain. (jneurosci.org)
  • dispensable
  • Whereas MHC class II-restricted αβ T cells are required for resistance ( 2 , 3 , 4 ), MHC class I-restricted T cells are dispensable ( 5 ). (jimmunol.org)
  • protein
  • Here, we report the isolation of an At Pep1-binding protein from Arabidopsis suspension-cultured cells. (pnas.org)
  • Characterization of tryptic digests of the purified receptor protein has led to the identification of the gene in the Arabidopsis Information Resource as At1g73080, a LRR receptor kinase. (pnas.org)
  • negative
  • A hallmark of autoimmune lymphoproliferative syndrome (ALPS), caused by mutation of the Fas death receptor, is massive lymphadenopathy from aberrant expansion of CD4 − CD8 − (double-negative [DN]) T cells. (jimmunol.org)
  • Thus, the peripheral T cell activation threshold during an infection is below that of negative selection for TRA. (rupress.org)