Cell receptor gene loci. Medical search. Frequent questions

Insulin receptor substrate (IRS) proteins play essential roles in mediating insulin/IGF signaling by recruiting a series of downstream effectors 23 . (nature.com)
What are the largest genes and proteins? (cshlpress.com)
The ALK gene is a hotspot for chromosomal translocation events that result in several fusion proteins that cause a variety of human malignancies 3 . (nature.com)
Mutations in these genes affect proteins involved in the signaling pathway for pigment production and explain a large amount of the color variation in mammals. (creation.com)
The HLA-DQB1 gene has many different normal variations, allowing each person's immune system to react to a wide range of foreign proteins. (medlineplus.gov)

It contributes the alpha chain to the larger TCR protein (T-cell receptor). (wikipedia.org)
How Many Protein-coding Genes Are Present in the Genome? (cshlpress.com)
Does Exon Number Correlate with Gene Size or Protein Size? (cshlpress.com)
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. (cancerindex.org)
The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). (cancerindex.org)
Alternatively spliced transcript variants that encode the same protein have been described for this gene. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Fusion of a kinase gene, ALK , to a nucleolar protein gene, NPM , in non-Hodgkin's lymphoma. (nature.com)
Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. (genetex.com)
RQ-PCR and Western blot analysis confirmed overexpression of IRS4 at the gene and protein level. (atlasgeneticsoncology.org)
We demonstrate here that ILT7 protein associates with the signal adapter protein Fc ε RIγ to form a receptor complex. (rupress.org)
The protein encoded by P2RY8 gene is composed of 359-amino acids and belongs to the P2Y family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. (atlasgeneticsoncology.org)
[ 10 ] The protein products of the HLA genes are critical components of cell-to-cell communication in the immune system. (medscape.com)
They found that the gene that codes for a protein called poliovirus receptor-like 4 (PVRL4) allows attachment-free cell growth and also makes cells cluster together once detached from the matrix. (elifesciences.org)
also showed that interactions between the PVRL4 in one cell and a related protein called PVRL1 in a neighboring cell were responsible for holding the cells together in clusters. (elifesciences.org)
Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. (novusbio.com)
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a central regulator of inflammatory cell function that coordinates inflammation, apoptosis and necroptosis in response to inflammatory stimuli. (neurosciencenews.com)
lyrata (Lyre-leaved rock-cress) hypothetical protein (at5g25770) , arath-C7A10.830 Arabidopsis thaliana DNA chromosome 4,gene C7A10.830 No. 2 AT4G36530 , arath-F1N18.12 Arabidopsis thaliana (Mouse-ear cress) f1n18.12 AT1G29840 protein , arath-F1P2.110 Arabidopsis thaliana (Mouse-ear cress). (inrae.fr)
This complex gene codes for a complex protein important in a number of pathways. (creation.com)
This complex organization of the gene reflects the complex nature of the protein receptor it produces. (creation.com)
Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. (nih.gov)
The most well-studied of these genes is HLA-DQB1 , which provides instructions for making part of a protein that plays an important role in the immune system. (medlineplus.gov)
For example, research designed to identify the protein structures where alcohol binds to nerve cells may, one day, provide groundwork for development of better medications to treat alcoholism. (nih.gov)
In another protein-related finding, NIAAA-supported scientists have found that genes in the brains of deceased human alcoholics produced less of a crucial nervous-system protein, myelin, than did those in nonalcoholics. (nih.gov)
Electrophoretic mobility shift assays detected allele-dependent nuclear protein binding in A549 cells for 8 of 21 variants. (cdc.gov)
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. (lu.se)

Genetic variants at the PTPN2 locus, which encodes the tyrosine phosphatase PTPN2, cause reduced gene expression and are linked to rheumatoid arthritis (RA) and other autoimmune diseases. (researchgate.net)
Hallberg, B. & Palmer, R. H. Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology. (nature.com)
ALK , the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). (nature.com)
They act as mediators between multiple growth factor receptors that possess tyrosine kinase activity, such as the insulin and insulin growth factor receptors, and a complex network of intracellular signalling molecules, resulting in activation of, for example, the PI3K and RAS/ERK pathways and subsequent transcription of target genes. (atlasgeneticsoncology.org)
4 It encodes a receptor tyrosine kinase involved in the development and homeostasis of several cell lines including melanocytic (pigment), hematologic (blood), mast, and germ cells. (creation.com)

CNTFR encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. (novusbio.com)

Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6. (ox.ac.uk)
The VDR gene is located on chromosome 12q12-14, which contains two promoters and 8 exons [ 11 ]. (hindawi.com)
Schematic diagram of the human X chromosome indicating the location of the P2RY8 gene. (atlasgeneticsoncology.org)
The P2RY8 gene is located on both chromosomes X and Y. It was discovered by Cantagrel and co-workers while investigating a pericentric inversion on the X chromosome, inv(X)(p22.3 q13.2), in a family with mental retardation. (atlasgeneticsoncology.org)
Fusion gene: a 320-kb large interstitial deletion within the pseudoautosomal region 1 (PAR1) on chromosome X [del(X)(p22.33p22.33)] and chromosome Y [del(Y)(p11.32p11.32)] results in juxtaposition of the first non-encoding exon of P2RY8 to the CRLF2 coding region to form P2RY8-CRLF2 fusion which leads to over-expression of full-length CRLF2. (atlasgeneticsoncology.org)
The higher risk of SLE in women and men with Klinefelter syndrome may be associated with enhanced expression of toll-like receptor 7 (TLR7), a key pathogenic factor in SLE that is encoded on an X chromosome locus. (medscape.com)

The locus encoding the T cell antigen receptor (TCR) α-chain and δ-chain (Tcra-Tcrd) undergoes recombination of its variable-diversity-joining (V(D)J) segments in CD4(-)CD8(-) double-negative thymocytes and CD4(+)CD8(+) double-positive thymocytes to generate diverse TCRδ repertoires and TCRα repertoires, respectively. (duke.edu)
chain region of the T cell antigen receptor gene rearranged to uniform V? (justia.com)

Our results show that there is a genetic contribution to musical aptitude that is likely to be regulated by several predisposing genes or variants. (bmj.com)
"RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice" by Denuja Karunakaran et al. (neurosciencenews.com)
Genetic variants with gene regulatory effects are associated with diisocyanate -induced asthma. (cdc.gov)
Four variants exhibited effects on gene regulation (ATF rs11571537, CDH17 rs2446824 and rs2513789, and TACR1 rs2287231). (cdc.gov)
These results demonstrate that many DA-associated genetic variants likely act by modulating gene regulation. (cdc.gov)
For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. (who.int)

The T-cell repertoire derives this high diversity through somatic recombination of the T-cell receptor (TCR) locus, a random process that results in repertoires that are largely private to each individual. (biorxiv.org)
The vast diversity of possible T-cell receptors (TCR) is generated by the random recombination of genes in the third complimentary determining regions (CDR3) within a TCR's α and β chains. (biorxiv.org)
In the recombination process of the β chain, loci of the variable (V), diversity (D), and joining (J) regions are randomly spliced together with non-templated insertions and deletions occurring between each junction, resulting in up to 10 11 possible sequences ( 3 , 4 ). (biorxiv.org)
Recombination of the TCRα chain includes only V and J gene segments, resulting in fewer possible rearrangements and making the TCRβ chain a more suitable target for identifying unique T cells, and thus the focus of this paper. (biorxiv.org)
Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. (biomedcentral.com)
The t(X;7)(q22;q34) in paediatric T-cell acute lymphoblastic leukaemia results in overexpression of the insulin receptor substrate 4 gene through illegitimate recombination with the T-cell receptor beta locus. (atlasgeneticsoncology.org)
We present a novel approach to deal with the problem of reconstructing the duplication history of tandemly repeated genes that are supposed to have arisen from unequal recombination. (cnrs.fr)

Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. (genetex.com)
The delta locus is situated within the alpha locus, between the alpha V and J segments. (genetex.com)

Seibold A, Brabet P, Rosenthal W, Birnbaumer M: Structure and chromosomal localization of the human antidiuretic hormone receptor gene. (hmdb.ca)
The final result is a heavy chain locus containing a mutated variable region (mutations are indicated by stars) and a chromosomal Sμ/Sγ1 junction (bottom). (biomedcentral.com)
The chromosomal loci encoding for the adjustable parts of TCRs and BCRs are complicated to decipher because of repetitive components and undocumented structural variations. (findadig.com)

To our knowledge, angiotensin converting enzyme ( ACE ) gene I/D polymorphisms have not yet been investigated in AS patients in Turkish population.This study was conducted in Turkish patients with AS to determine the frequency of I/D polymorphism genotypes of angiotensin converting enzyme gene. (molvis.org)
Outcomes From the incomplete and complete AIRR-seq TCR data models, we determined 39 undocumented polymorphisms in T cell receptor Beta V (TRBV) and 31 undocumented 5 UTR sequences. (findadig.com)
Identity between most parsimonious duplication trees and most parsimonious phylogenies for the same data, combined with the agreement with additional knowledge about the sequences, such as the presence of polymorphisms, shows strong evidence that our reconstruction procedure providesgood insights into the duplication histories of these loci. (cnrs.fr)
Here we show that genetic polymorphisms near the human RIPK1 locus associate with increased RIPK1 gene expression and obesity. (neurosciencenews.com)
We show that one of these single nucleotide polymorphisms is within a binding site for E4BP4 and increases RIPK1 promoter activity and RIPK1 gene expression in adipose tissue. (neurosciencenews.com)
Fourteen loci with known DA-associated single nucleotide polymorphisms (SNPs) were sequenced and compared with data from 238 unexposed subjects. (cdc.gov)

PTPN2 inhibits signaling through the T cell and cytokine receptors and loss of PTPN2 promotes T cell expansion and CD4 and CD8-driven autoimmunity. (researchgate.net)

There's a lot of interest in single-cell sequencing and expression. (cincinnatichildrens.org)
We are interested in the molecular basis for developmentally regulated rearrangement and expression of murine TCR genes. (duke.edu)
These elements are involved in control of gene expression which governs the phenotype and also plays role in disease biology. (researchgate.net)
North WG, Fay MJ, Longo KA, Du J: Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. (hmdb.ca)
Fay MJ, Du J, Yu X, North WG: Evidence for expression of vasopressin V2 receptor mRNA in human lung. (hmdb.ca)
RA-RARα activity limited murine Th9-associated pulmonary inflammation, and human allergic inflammation was associated with reduced expression of RA target genes. (nih.gov)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Astrocytes augmented HIF-1α expression in glioblastoma cells under hypoxia. (cancerindex.org)
The expression of HIF-1 downstream genes, cancer colony formation, and Matrigel invasion of glioblastoma cells were stimulated by conditioned medium from astrocytes pre-exposed to hypoxia. (cancerindex.org)
Expression of IRS1 , IRS2 or IRS4 in the 32D haematopoietic cell line leads to proliferation of the myeloid progenitor cells and expression of activated IRS4 has recently been demonstrated in the human hepatoblastoma cell line HepG2, with inhibition of IRS4 resulting in diminished growth. (atlasgeneticsoncology.org)
2004). Adundant expression of P2RY8 has been demonstrated in bone marrow CD34+ cells in leukaemic patients (Fujiwara et al. (atlasgeneticsoncology.org)
2007). However P2RY8 expression appears to be down-regulated during leucocyte differentiation: normal, mature peripheral blood leucocytes have been shown to have minimal expression, while an undifferentiated promyelocytic leukaemia cell line was shown to have moderate expression of P2RY8 that was down-regulated with induction of granulocyte differentiation (Adrian et al. (atlasgeneticsoncology.org)
Using retroviral expression screening for transforming genes in biphenotypic acute leukaemia, P2RY8 has been confirmed to have oncogenic potential (Fujiwara et al. (atlasgeneticsoncology.org)
An interstitial deletion of the pseudoautosomal region 1 (PAR1) of either of the sex chromosomes results in juxtaposition of the first noncoding exon of the P2RY8 gene to the first exon of CRLF2, such that CRLF2 expression from this chimeric locus is driven by the P2RY8 promoter. (atlasgeneticsoncology.org)
These things together could disrupt essential gene functions and affect surrounding functional gene expression. (labroots.com)
Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. (novusbio.com)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
The enhancers, along with the LTR promoter sequence, supported efficient expression of the corrective IL2RG gene and allowed successful gene correction. (europeanhealthjournal.com)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
In the luciferase assay 4 of the 21 SNPs exhibited allele-dependent changes in gene expression. (cdc.gov)
CHRNA5 expression research findings from the laboratory to CHRNA5 was among the markers with in bronchial cel s modulates cell the population. (who.int)
CHRNA3 gene expression disease associations. (who.int)
A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. (lu.se)

Wildin RS, Antush MJ, Bennett RL, Schoof JM, Scott CR: Heterogeneous AVPR2 gene mutations in congenital nephrogenic diabetes insipidus. (hmdb.ca)
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. (nature.com)
CRLF2 alterations are associated with the presence of activating mutations in the JAK genes JAK1 and JAK2 (Russell et al. (atlasgeneticsoncology.org)
reviewed in Roll and Reuther, 2010), as well as mutations of the lymphoid transcription factor gene IKZF1 (IKAROS) (Harvey et al. (atlasgeneticsoncology.org)
Mutations of the inflammatory RIPK1 gene have been identified in people with obesity. (neurosciencenews.com)

For flow cytometry of cell suspensions from peripheral lymphoid tissues, it is recommended that multicolor staining be performed to distinguish T lymphocytes from non-T cells. (bdbiosciences.com)
Souyris et al reported that in both females and males with Klinefelter syndrome, substantial fractions of primary B lymphocytes, monocytes, and plasmacytoid dendritic cells express TLR7 on both X chromosomes, leading to greater immunoglobulin secretion. (medscape.com)
T-lymphocytes recognize antigens via a mechanism that resembles that used by immunoglobulins produced by B cells. (creative-biolabs.com)
Lymphocytes, B and T cells, can respond selectively to thousands of non-self materials. (lu.se)

However, certain factors such as low junctional diversity, thymic selection, and T-cell proliferation upon antigen exposure can affect TCR sharing among individuals. (biorxiv.org)
A gain of function screen for genes that enable proliferation independently of matrix anchorage identified a cell adhesion molecule PVRL4 (poliovirus-receptor-like 4), also known as Nectin-4. (elifesciences.org)

Mechanistically, the CCL20/CCR6 signaling pathway upregulates HIF-1α by stimulating nuclear factor kappa B-driven transactivation of the HIF1A gene. (cancerindex.org)

As a result of our study, angiotensin converting enzyme gene I/D polymorphism DD genotype could be a genetic marker in ankylosing spondylitis in a Turkish study population. (molvis.org)
Body S11 TRBV gene use based on the TRBV7-2 genotype in DS3. (findadig.com)
SOLUTIONS TO confront this problem, AIRR-seq-based strategies have already been created for B cells lately, allowing haplotype and genotype inference and discovery of undocumented alleles. (findadig.com)
Here, we modified a B cell pipeline for undocumented alleles, genotype, and haplotype inference for complete and incomplete AIRR-seq TCR data models. (findadig.com)
in an NKT cell receptor-specific way, wherein an administration subject is an allogenic individual having MHC gene loci including at least one locus having a genotype different from that of the NKT cell. (justia.com)
Deficiencies are highly variable with regard to symptoms, phenotype, genotype, severity, etc, because many cells and molecules are required for both natural and adaptive immunity . (lu.se)

This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (cancerindex.org)
Three of these genes (delta like canonical notch ligand 1, jagged1 and notch receptor 1) affect cell differentiation and growth and interact with mitochondrial function. (nsf.gov)

CRISPR/Cas9 gene-editing technology can achieve targeted insertion of CAR construct sequence in the desired locus such as T cell receptor locus (TRAC) or any genomic safe harbor sites. (labroots.com)

A genome-wide study in a northern European population replicated the association of SLE with susceptibility genes related to B-cell receptor pathway signaling, as well as confirmed the association of SLE with genes at the interferon regulatory factor 5 (IRF5)-TNPO3 locus. (medscape.com)
Development of asthma is multifactorial and depends on the interactions among multiple susceptibility genes and environmental factors. (msdmanuals.com)
More than 100 asthma susceptibility genes have been reported. (msdmanuals.com)

High knockin efficiency at the TRAC locus with MaxCyte electroporation. (maxcyte.com)
Efficient integration of CAR genes into targeted sites such as the T Cell Receptor Alpha Constant (TRAC) locus has proved challenging even with precision genome engineering tools. (maxcyte.com)

Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. (nih.gov)
A second trial (SCIDn2) was carried out to treat SCID-X1 using an improved self-inactivated vector in which the LTR strong enhancer sequences were deleted [ 19 ], and a promoter comprised of the short elongation factor 1 alpha (EF1a) promoter, devoid of enhancer regions, was used to express the therapeutic IL2RG gene. (europeanhealthjournal.com)

Consistent with this hypothesis, we find that increased age is correlated with decreased overall TCRβ clone sharing, indicating that the pattern of private TCRβ clonal expansion is a general feature of the T-cell response to other infectious antigens. (biorxiv.org)
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). (genetex.com)
Genetically engineering T cells to express CARs that recognize tumor-associated antigens is an approach that holds immense potential for treating cancer. (maxcyte.com)
Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)
Gamma-delta T cells may also recognize antigens directly without presentation by the major histocompatibility complex. (creative-biolabs.com)

We discovered that an individual nucleotide polymorphism differentiating between your two noted T cell receptor Beta D2 (TRBD2) alleles is certainly strongly connected with dramatic adjustments in the portrayed repertoire. (findadig.com)
Also, although there were only two humans, Eve may have carried alleles in her egg cells that differed from those in her body. (creation.com)
Thus, up to four alleles for any particular locus could have been present. (creation.com)
Conversely, alleles from one parental species at some loci may provide a selective advantage to hybrids, resulting in patterns of introgression that do not conform to random expectations. (nsf.gov)

VDR belongs to the nuclear receptor family with a typical nuclear receptor domain, including DNA-binding domain, a hinge region, a ligand-binding domain, and a carboxy-terminal activation function 2 domain that interacts with coregulators [ 10 ]. (hindawi.com)
This mechanism is underpinned by an unusual architecture of the receptor-ligand complex. (nature.com)

A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires. (duke.edu)
Abstract History B and T cell receptor (TCR, BCR) repertoires constitute the building blocks of adaptive immunity. (findadig.com)

CART cell production using viral vectors to deliver the transgene results in the random insertion of CAR sequence across the whole genome. (labroots.com)
However, this process relies on full coverage from the receptors adjustable locations, whereas most T cell research sequence a part of that area. (findadig.com)
The exception is the final exon which not only codes the terminal portion of the receptor, but also includes a 2,147 bp non-coding sequence that follows. (creation.com)

Early in B- and T-cell development, site-specific cleavage and rejoining of V, D and J gene segments occurs to encode functional antigen receptors. (biomedcentral.com)

1 Some of these, such as the MC1R 2 and ASIP 3 genes, have been fairly well studied and useful information has been obtained by examining mutation patterns at these loci. (creation.com)
Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene therapy. (europeanhealthjournal.com)

What Is the Size Distribution of snRNA Genes and Related Sequences in the Genome? (cshlpress.com)
In addition to random CAR insertion viral vectors also deliver partial viral sequences into the cell genome. (labroots.com)
The pipeline handles gene project ambiguities also, which is important in the analysis of data sets of partial sequences specifically. (findadig.com)
DNA sequences encoding the delta chain of the T-cell receptor. (nih.gov)
In this study, we combine thousands of genotyping-by-sequencing (GBS) loci with mtDNA sequences (ND1) from the Texas horned lizard (Phrynosoma cornutum) to quantify relative support for different catalysts of diversification. (nsf.gov)

RA acts through its receptor RARα to repress transcription of inflammatory cytokines, but is also essential for Th-mediated immunity, indicating complex effects of RA on Th specification and the outcome of the immune response. (nih.gov)
Downregulated transcripts were found for the ATM interactome component Usp2, many non-coding RNAs, ataxia genes Itpr1, Grid2, immediate early genes and immunity factors. (preprints.org)
Among immune cells, Foxp3 + regulatory T cells (Treg cells) are potent inhibitors of cancer immunity, and their presence within solid tumors is generally associated with a poor prognosis. (mdpi.com)
SCID-X1 gene therapy results in reconstitution of the previously lacking T cell compartment, allowing analysis of the roles of T cell immunity in humans by comparing before and after gene correction. (europeanhealthjournal.com)

Every antibody producing cell can have its own genome," says Roskin. (cincinnatichildrens.org)
How many genes are in the human genome? (cshlpress.com)
Which Genes Are Present in the Mitochondrial Genome? (cshlpress.com)
How Are Genes Organized in the Mitochondrial Genome? (cshlpress.com)
How Are microRNA Genes Distributed in the Genome? (cshlpress.com)
In all cells, high-fidelity pathways repair DNA to maintain the integrity of the genome. (biomedcentral.com)
Genome-wide association studies have identified more than 100 genetic loci for SLE susceptibility across populations, with most of the genetic risk shared across borders and ethnicities. (medscape.com)
The popular method for the generation of CART cell drug product is delivery of CAR and its integration into the T cell genome using viral vectors. (labroots.com)

As the MHC is encoded by highly polymorphic human leukocyte antigen (HLA) loci in humans, this process of thymic selection occurs within the context of an individual's HLA type. (biorxiv.org)
It is estimated that up to 90% of cancers in humans originate in epithelial tissue, and the cells within such tumors are known to survive and divide even when they are no longer attached to the extracellular matrix. (elifesciences.org)
One locus important in embryogenesis, KIT , has been associated with white coat patterns in several mammalian species and piebaldism in humans. (creation.com)

Ranking of DA-associated SNPs based on their likelihood to affect gene regulatory mechanisms in the lung yielded 21 prioritized SNPs. (cdc.gov)

If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. (genetex.com)
also known as the thymic stromal lymphopoietin receptor), which together with IL7 receptor alpha forms a heterodimeric complex that acts at the functional receptor for thymic stromal lymphopoietin (reviewed in Roll and Reuther, 2010). (atlasgeneticsoncology.org)

Notch2 positively regulates self-renewal of liver cancer cells. (nih.gov)

In contrast, non-Hodgkin lymphoma is best regarded as a systemic disease, because of the unique anatomy of the lymphoid system and because of the physiology of lymphoid cells, which tend to migrate whether they are normal or malignant. (medscape.com)

Vitamin D receptor (VDR) gene polymorphism is considered to be an important cause of cancer development. (hindawi.com)
To determine fl agellin membrane receptor), signifi cantly more than the other 113 types, we used an Rsa I-based PCR-restriction fragment EAEC isolates (and 39.8% and 24.8% for iucA and chuA, length polymorphism (RFLP) protocol. (cdc.gov)

The gene is preferentially expressed by immature dendritic cells and memory T cells. (cancerindex.org)
Transcripts for one member of this family, ILT7, are selectively expressed in human plasmacytoid dendritic cells (pDCs). (rupress.org)

Which Genes Have the Most Exons? (cshlpress.com)
The gene is composed of 4 exons and the promoter region contains the regulatory transcription factor binding sites for CREB, POU3F1 and deltaCREB. (atlasgeneticsoncology.org)
The KIT gene is rather complex consisting of 21 exons in a 70 kb region. (creation.com)

There are 2 main mature T-cell subtypes, those expressing alpha and beta chains, and those expressing gamma and delta chains. (creative-biolabs.com)

How Does Codon Usage Vary Among Human Genes? (cshlpress.com)
There are eight mammalian P2Y receptors known to date ( P2Y1 , P2Y2 , P2Y4 , P2Y6 , P2Y11 , P2Y12 , P2Y13 and P2Y14 ) and they are found in most human tissues. (atlasgeneticsoncology.org)
explored which genes enable epithelial cells from the human mammary gland to grow without being attached to the extracellular matrix. (elifesciences.org)
nS/MARt vector expressing the CEA-CAR delivered with high efficacy and viability into activated human CD3+ cells. (maxcyte.com)
We use real data sets of human immunoglobulins and T-cell receptors to validate our methods and algorithms. (cnrs.fr)
Validation experiments with stressors were performed in human neuroblastoma cells, where ATM localized only to cytoplasm, similar to brain. (preprints.org)
Provided are a B cell-derived iPS cell generated using a convenient technique, a technology for providing a human antibody at low cost using the iPS cell, an immunologically humanized mouse prepared using cells differentiated from the iPS cell, and the like. (justia.com)
If NPY is found to play a key role in human alcohol-use disorders, NPY and its receptors -- its "docking sites" on cells -- become potential targets for medications to control alcohol intake. (nih.gov)
SCID-X1 gene therapy thus provides a unique opportunity to study the consequences of T cell function in previously deficient human subjects. (europeanhealthjournal.com)
Daneshpajooh M, Bacos K, Bysani M, Bagge A, Ottosson Laakso E, Vikman P, Eliasson L, Mulder H, Ling C. HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells. (lu.se)

Cell 181 , 1246-1262 (2020). (nature.com)
2020) Inflammation by pattern recognition receptors in the uterine wall decidua and the placenta of normal and preeclamptic pregnancies. (ntnu.edu)

The present invention provides a method of producing a mammalian ES cell, including cultivating a mammalian inner cell mass in a medium containing adrenocorticotropic hormone, an FGF receptor inhibitor, an MEK activation inhibitor and a GSK3 inhibitor, and isolating a mammalian ES cell from the culture. (justia.com)

Which Genes Host Small Nuclear RNAs and Small Nucleolar RNAs? (cshlpress.com)
Our results suggest that differential non‐random introgression for a subset of loci may be driven by selection favouring the inheritance of compatible mitochondrial and nuclear‐encoded genes in hybrids. (nsf.gov)
Risk and nonrisk oligonucleotides were tested for binding of nuclear extracts from A549, BEAS-2B, and IMR-90 lung cell lines by using electrophoretic mobility shift assays. (cdc.gov)

Antigen recognition depends on both T-cell specificity and the molecular complex presenting the antigen. (biorxiv.org)
Coupled with selection for B cells expressing high-affinity antigen receptors, hypermutation enhances the efficiency and specificity of the immune response. (biomedcentral.com)

Here, single-cell and bulk transcriptomic analysis of T RM and non-T RM cells present in tumor and normal lung tiss. (researchgate.net)
During tumor development, stromal cells are co-opted to the tumor milieu and provide favorable conditions for the tumor. (cancerindex.org)
During all stages of tumor progression, cancer cells are subjected to inappropriate extracellular matrix environments and must undergo adaptive changes in order to evade growth constraints associated with the loss of matrix attachment. (elifesciences.org)
Understanding how cancerous cells gain this ability may lead to new approaches to stopping tumor cells from dividing and colonizing tissues around the body. (elifesciences.org)
Explore how MaxCyte enabled the cGMP manufacture of stable CAR T cells with enhanced anti-tumor activity in only five days. (maxcyte.com)
ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
This role explains T-cell dysfunction and tumor risk. (preprints.org)

T cells make up a key component of the adaptive immune response and allow the body to respond to the diverse range of pathogens it may encounter. (biorxiv.org)
T cells that encounter their specific cognate MHC-presented antigen will bind and proliferate, leading to an immune response. (biorxiv.org)
A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene. (bvsalud.org)

T cells mature in the thymus, where their affinity to MHC molecules is tested prior to subsequent release into the periphery. (biorxiv.org)
Unlike secreted Ig molecules, T-cell receptor chains are membrane bound and act through cell-cell contact. (creative-biolabs.com)
The immune system consists of a large number of molecules and processes, and immunodeficiencies can therefore be caused by genetic alterations at many loci. (lu.se)

ApoE interacts with multiple ligands, among them triggering-receptor expressed on myeloid cells 2 (TREM2), which is greatly implicated in neuroinflammation [5]. (lu.se)

KIT has also gone by several other names including c-kit , v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, stem cell factor receptor, mast cell growth factor receptor, and CD117 . (creation.com)

Later, upon B-cell activation, the immunoglobulin loci undergo two additional and distinct genetic alterations (Figure 1 ). (biomedcentral.com)

HEp-2 cell adherence assay ( 3,4 ). (cdc.gov)

C57BL) of the Tcrb gene complex. (bdbiosciences.com)
The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. (novusbio.com)
Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. (novusbio.com)
Demographic analyses support a complex history, with introgression and gene flow playing an important role during diversification. (nsf.gov)
HAM-ART: An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities. (cdc.gov)
Kaptive 2.0: updated capsule and lipopolysaccharide locus typing for the Klebsiella pneumoniae species complex. (cdc.gov)

The murine immunoglobulin heavy chain locus is shown (top line) with a rearranged variable (VDJ) region juxtaposed to the Cμ constant region. (biomedcentral.com)

A diagnose of T-cell acute lymphoblastic leukaemia was made. (atlasgeneticsoncology.org)

Moreover, our group has recently evidenced that early-life infection in 5xFAD mice induces a subpopulation of microglial cells with a monocyte-like profile presenting as potential markers genes corresponding to Gal3, and APOE. (lu.se)

This region represents the germline organization of the T cell receptor alpha and delta loci. (genetex.com)

Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. (genetex.com)
In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. (genetex.com)
If not, the cell proceeds to rearrange the beta and alpha loci. (genetex.com)
2) Estimation of T cell population structure by sequencing of the recombined T cell receptor (TCR) beta locus. (europeanhealthjournal.com)

PCR identifi ed 3 EAEC-specifi c and 2 other virulence that correlates with multilocus enzyme electrophoresis typ- genes ( 2,6 ). (cdc.gov)

In this review, we summarize the current knowledge on the different intracellular pathways involved in the programming of Treg cell homeostasis and functions in cancer. (mdpi.com)

Solid tumors frequently have copy number gains of the PVRL4 locus and some have focal amplifications. (elifesciences.org)
Furthermore, growth of orthotopically implanted tumors in vivo is inhibited by blocking PVRL4-driven cell-to-cell attachment with monoclonal antibodies, demonstrating a novel strategy for targeted therapy of cancer. (elifesciences.org)
Normally, the PVRL4 gene is not active in breast epithelial cells, but its activity is detected in many breast, lung, and ovarian tumors. (elifesciences.org)
This behavior is particularly evident in the cells that divide aggressively to form tumors that subsequently migrate and colonize other tissues around the body. (elifesciences.org)
used genetic techniques to silence PVRL4 in cells from breast tumors, they found that it reduced the formation of clusters by the cancer cells and also reduced their ability to grow in the absence of attachment. (elifesciences.org)

These gene loci are deleted in mice having the a (e.g. (bdbiosciences.com)
A gene that helps to control inflammation increases the risk of obesity and could be turned off in mice to stop weight gain, a study from The University of Queensland has found. (neurosciencenews.com)
The researchers then looked at the effect of turning the inflammatory gene on and off in mice. (neurosciencenews.com)
Without the gene, the mice remained at a normal weight despite eating a high-fat diet and their risk of diabetes was reduced. (neurosciencenews.com)
The mice with a normal level of the inflammatory gene put on weight from eating the same high-fat diet. (neurosciencenews.com)
Surprisingly, these studies revealed that mice in which the NPY gene was in activated (knocked out) drank more alcohol than did their normal siblings and were less sedated by alcohol. (nih.gov)

That cell could be hiding out in the bone marrow and be much easier to find there. (cincinnatichildrens.org)
Normal plasma cells are found in the bone marrow and are an important part of the immune system. (invivoscribe.com)
Leukocytes are produced in stem cells in bone marrow. (lu.se)

Here we identified a chromatin-interaction network in the Tcra-Tcrd locus in double-negative thymocytes that was formed by interactions between binding elements for the transcription factor CTCF. (duke.edu)
How Many Genes Are in the Major Transcription Factor Families? (cshlpress.com)

Anatomy35

Organisms9

Diseases7

Chemicals and Drugs82

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes117

Disciplines and Occupations1

Information Science4

Health Care2

Proteins5

Protein27

Tyrosine5

Encodes1

Chromosome6

Antigen receptor2

Variants6

Recombination7

Delta locus2

Chromosomal3

Polymorphisms6

Cytokine receptors1

Expression23

Mutations5

Lymphocytes4

Proliferation2

Signaling pathway1

Genotype6

Differentiation2

Genomic1

Susceptibility genes3

TRAC2

Enhancer2

Antigens5

Alleles4

Ligand2

Repertoires2

Sequence3

Segments1

Mutation2

Sequences5

Immunity4

Genome8

Humans3

SNPs1

Functional2

Regulates1

Lymphoid1

Polymorphism2

Dendritic cells2

Exons3

Subtypes1

Human10

20202

Mammalian1

Nuclear3

Specificity2

Tumor7

Immune response3

Molecules3

Myeloid1

Homolog1

Genetic alterations1

Assay1

Complex6

Murine1

Acute lymphobla1

Markers1

Germline1

Beta4

Enzyme1

Pathways1

Tumors5

Mice6

Bone marrow3

Transcription2