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  • Side Effects Of C
  • Prana Therapeutics is a biotech company focused on developing targeted therapeutics for prevention of the negative side effects of chemotherapy, management of rheumatoid arthritis, and treatment of brain cancer. (yahoo.com)
  • As nail toxicity still occurred in a minority of participants, who had marked general side effects of chemotherapy, further research combining this balm with cooling would be justified. (springer.com)
  • attenuate
  • To investigate whether hAECs-secreting cytokines act as molecular basis to attenuate chemotherapy-induced ovarian injury, hAECs or hAEC-conditioned medium (hAEC-CM) was injected into the unilateral ovary of POF/POI mouse. (biomedcentral.com)
  • The results suggested that the oral administration of CI SCFE combined with BLM could markedly prolong the life span, attenuate the BLM-induced pulmonary fibrosis, suppress the production of pro-inflammatory cytokines (interleukin-6), tumor necrosis factor-α, activities of myeloperoxidase, and malondiadehyde. (mdpi.com)
  • neurons
  • Human pluripotent stem cell-derived neurons with visual cortex identity show circuit-specific integration into lesioned mouse visual cortex but not lesioned motor cortex. (sciencemag.org)
  • Here, we describe radiosensitizing mutation 7 ( rs7 ), which causes a severe sensitivity of zebrafish embryonic neurons to IR-induced apoptosis and is required for the proper development of the central nervous system. (plos.org)
  • It is believed that neuropathy develops over time as a cumulative effect of chemotherapy that alters functions in neurons-or nerve cells. (iu.edu)
  • We hypothesize that APE1 is a critical protein for protecting neurons from cancer therapies and that augmenting its DNA repair activity will prevent and reverse chemotherapy-induced alterations in sensory neuronal function," Dr. Kelley explained. (iu.edu)
  • it blocks tumor cell growth while protecting neurons and reducing or preventing CIPN," Dr. Kelley said. (iu.edu)
  • tumors
  • In mice bearing HeLa tumors, systemically injected Au-ODNs concentrated in the liver and prevented DOX-induced weight loss-a common measure of systemic chemotoxicity-without significantly inhibiting the antitumor effectiveness of DOX over 24 days. (sciencemag.org)
  • Another challenge is to design nanocomposites that more effectively partition away from tumors and into the numerous healthy organs adversely affected by chemotherapy. (sciencemag.org)
  • In pre-clinical rodent testing, Epidiferphane™, in conjunction with a nutritional ketosis, has been shown to double the mean life expectancy, increase the effectiveness of chemotherapy, and sensitize chemotherapy resistant tumors to standard of care drugs. (yahoo.com)
  • Acute
  • PURPOSE: To determine the effect of reducing MAP kinase phosphatase-1 (MKP-1) levels on cell death induced by glucocorticoid (GC) or hydroxyurea (HU) treatment in the human pre-B acute lymphoblastic leukemia cell line 697. (jefferson.edu)
  • grape seed
  • A study published in PLOS ONE shows that grape seed extracts may aid the effectiveness of chemotherapy in killing colon cancer cells as well as reducing the chemotherapy's side effects. (ift.org)
  • Our research also showed that in laboratory studies grape seed taken orally significantly reduced inflammation and tissue damage caused by chemotherapy in the small intestine, and had no harmful effects on non-cancerous cells. (ift.org)
  • Unlike chemotherapy, grape seed appears to selectively act on cancer cells and leave healthy cells almost unaffected," said Cheah, Researcher at the University of Adelaide's School of Agriculture, Food, and Wine. (ift.org)
  • Grape seed extract alleviates high-fat diet-induced obesity and heart dysfunction by preventing cardiac siderosis. (springer.com)
  • epithelial cell
  • Knocking down SPINK7 in an epithelial cell line led to barrier disruption and inflammatory cytokine production, which could be reversed with an antiserine protease. (sciencemag.org)
  • Factors derived from Escherichia coli Nissle 1917, grown in different growth media, enhance cell death in a model of 5-fluorouracil-induced Caco-2 intestinal epithelial cell damage. (nih.gov)
  • autocrine
  • Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop," Blood , vol. 88, no. 10, pp. 3972-3986, 1996. (hindawi.com)
  • LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling. (unibas.ch)
  • cancer
  • Development of a screen using inner ear sensory hair cell-like cells made by direct lineage reprogramming, for discovering drugs to ameliorate hearing loss during cancer chemotherapy. (ca.gov)
  • Cancer in both children and adults is frequently treated with chemotherapy agents that have a high potential to damage hearing. (ca.gov)
  • In this context, it has been shown that TrkB, signaling through the phosphatidylinositol-3-kinase/AKT signaling axis, protects cancer cells from chemotherapy-induced apoptosis. (aacrjournals.org)
  • Taken together, these results indicated that CI SCFE could enhance the anti-cancer activity of BLM and reduce the BLM-induced pulmonary injury in H22 tumor-bearing mice, rendering it as a potential adjuvant drug with chemotherapy after further investigation in the future. (mdpi.com)
  • Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells," Cancer Research , vol. 66, no. 1, pp. 184-191, 2006. (hindawi.com)
  • APOPTOSIS, a morphologically distinguished type of programmed cell death, is critical not only during development but also in the pathogenesis of a variety of diseases including cancer, autoimmune disease, viral infection, and neurodegenerative disorders. (bloodjournal.org)
  • This is exemplified by small-cell lung cancer (SCLC). (clinsci.org)
  • VEGF-mediated angiogenesis links EMT-induced cancer stemness to tumor initiation. (unibas.ch)
  • Cancer cell, Vol. 23, H. 6. (unibas.ch)
  • In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought to mediate the successful elimination of cancer cells. (plos.org)
  • Future studies in human cancer cells will determine whether pharmacological inactivation of CCDC94 reduces the threshold of the cancer cell apoptotic response. (plos.org)
  • Radiation therapy and most chemotherapies elicit cancer cell death through the induction of excessive DNA damage. (plos.org)
  • To identify cellular components whose targeted therapeutic inactivation could potentially enhance the sensitivity of treatment-resistant cancer cells to DNA-damaging therapies, we have chosen an unbiased genetic approach in live whole zebrafish embryos to identify genes that normally protect cells from the lethal effects of DNA damage. (plos.org)
  • Future experiments that inactivate Ccdc94 and Prp19 complex proteins in human cancer cells will determine if inactivation of this complex represents a novel therapeutic strategy that could increase p53 expression to enhance sensitivity to DNA damaging therapies in chemo- and radio-resistant cancer cells. (plos.org)
  • In this article, we turn our focus to ovarian cancer and have searched for published research that would support or discourage the use of antioxidants in combination with chemotherapy. (pinestreetfoundation.org)
  • Rather, the studies that support this view simply show that ovarian cancer cells that are resistant to chemotherapy often have naturally higher levels of glutathione, which is one of the body's most important and natural antioxidants. (pinestreetfoundation.org)
  • 2006) Buthionine sulfoximine is a chemical that lowers glutathione levels and numerous studies also find that adding buthionine sulfoximine sensitizes ovarian cancer cells to chemotherapy drugs. (pinestreetfoundation.org)
  • We also point out specifically which studies were conducted in a laboratory (i.e. used cancer cell cultures), used animals, or involved human volunteers. (pinestreetfoundation.org)
  • Deregulation of cell death mechanisms in the skin can lead to diseases such as cancer, necrolysis and graft-versus-host disease. (springer.com)
  • Researchers at the Fred Hutchinson Cancer Research Center, and eleven other leading leukemia centers, including University of Chicago Medical Center, MD Anderson Cancer Center, The University of Pennsylvania Cancer Center, Wayne State University, and the City of Hope Medical Center, are working with Wyeth-Ayerst Laboratories and Celltech Chiroscience to study Mylotarg, an antibody-drug conjugate that targets chemotherapy treatment to leukemia cells. (fredhutch.org)
  • INDIANAPOLIS - Indiana University cancer researchers have been awarded $2.9 million to study the debilitating side effects caused by chemotherapy that affect a significant number of cancer patients. (iu.edu)
  • experiments
  • Finally, transfection experiments combined with drug treatments performed in the UACC-62 and SK-MEL-5 melanoma cells corroborated miR-195 as potential anti-proliferative agent, with potential impact in sensitization of melanoma cell death. (biomedcentral.com)
  • Cell elongation and migration were analyzed in transwell-filter experiments. (springer.com)
  • mesenchymal
  • Human embryonic stem cell-derived mesenchymal stromal cell transplantation in a rat hind limb injury model," Cytotherapy , vol. 11, no. 6, pp. 726-737, 2009. (hindawi.com)
  • TFAP2A is a component of the ZEB1/2 network that regulates TGFB1-induced epithelial to mesenchymal transition. (unibas.ch)
  • Angiogenesis
  • Results revealed that 109 cytokines in hAEC-CM might participate in a variety of biological processes including apoptosis, angiogenesis, cell cycle and immune response. (biomedcentral.com)
  • Furthermore, hAEC-CM was shown to promote angiogenesis in the injured ovaries and enhance the tube formation of human umbilical vein endothelial cells (hUVECs) in co-culture system. (biomedcentral.com)
  • An immature B cell population from peripheral blood serves as surrogate marker for monitoring tumor angiogenesis and anti-angiogenic therapy in mouse models. (unibas.ch)
  • kinase
  • The interaction between TRAIL and the death receptors (TRAIL-R1 and TRAIL-R2) leads to the recruitment of Fas-associated death domain kinase (FADD) and activates caspase-8 to promote cell death without the involvement of mitochondria. (aacrjournals.org)
  • 2 - 5 The surface immunoglobulin (Ig) component of the BCR in patients with progressive disease is usually encoded by unmutated variable heavy-chain (V H ) region genes and associates with the T-cell-specific protein tyrosine kinase zeta-associated protein 70 (ZAP-70). (bloodjournal.org)
  • disease
  • Lack of human inner ear hair cells for drug discovery purposes and disease modeling. (ca.gov)
  • 3 - 9 In contrast, CLL B cells from patients with stable disease usually express IgM encoded by mutated Ig V H genes and do not express ZAP-70. (bloodjournal.org)
  • clinical
  • The profoundly lower levels of physical nail damage and improvements in nail-related quality of life in the cohort applying the plant-based balm in this robustly designed RCT strongly suggest that this balm will benefit future patients receiving chemotherapy in route clinical practice. (springer.com)
  • 1 Recent studies have indicated that the B-cell receptor (BCR) is a major determinant of the clinical course in CLL. (bloodjournal.org)
  • No substantial clinical research has emerged to support the assertion that antioxidants are contraindicated during chemotherapy. (pinestreetfoundation.org)
  • apoptotic
  • To identify novel mechanisms that protect cells from the cytotoxic effects of DNA DSBs, we performed a forward genetic screen in zebrafish for recessive mutations that enhance the IR-induced apoptotic response. (plos.org)
  • One of the major environmental insults to the skin is UVB radiation, causing the occurrence of apoptotic sunburn cells. (springer.com)
  • treatment
  • These negative side effects reduce quality of life, can be life threatening and result in dose reductions and treatment delays, both which reduce the efficacy of chemotherapy. (yahoo.com)
  • Interestingly, MMC treatment causes chromosomal instability that is quantitatively, but not qualitatively, comparable to that seen in FA cells. (pnas.org)
  • The research that supports the concern about the use of antioxidants during chemotherapy treatment does not directly combine antioxidants and chemotherapy in human, animal, or cell culture studies. (pinestreetfoundation.org)
  • ovarian
  • Previous studies have demonstrated that transplantation of hAECs effectively alleviate chemotherapy-induced ovarian damage via inhibiting granulose cells apoptosis in animal models of premature ovarian failure/insufficiency (POF/POI). (biomedcentral.com)
  • There is no satisfying protective strategy to avoid chemotherapy-induced premature ovarian failure/insufficiency (POF/POI). (biomedcentral.com)
  • Recently, many studies in the field of regenerative medicine showed that stem cells transplantation might provide an important methodology for restoring ovarian function. (biomedcentral.com)
  • myeloid
  • Increased level of both CD4+FOXP3+ Regulatory t Cells and CD14+HLA-DR − /low myeloid-derived suppressor cells and decreased level of dendritic cells in patients with multiple myeloma," Scandinavian Journal of Immunology , vol. 72, no. 6, pp. 540-547, 2010. (hindawi.com)
  • 2001). Copper/Zinc superoxide dismutase is phosphorylated specifically by granulocyte-colony stimulating factor in myeloid cells. (springer.com)
  • evidence
  • Scientific evidence for practical strategies to reduce this distressing and unsightly side effect of one of the most commonly used chemotherapy drugs is long overdue. (springer.com)