• In addition, LY2606368 has demonstrated potent single agent activity and potentiates the anti-tumor activity of DNA damaging agents in vivo. (chemspider.com)
  • Autophagy may represent a mechanism of resistance to oxidative stress induced by chemotherapeutic drugs and may potentiate cancer cell survival to hypoxia and nutrient starvation due to the frequently defective tumor vascularization. (nature.com)
  • Inflammation is a critical component of tumor progression as sustained cell proliferation in an inflammatory microenvironment rich in growth factors, activated stroma, and DNA-damage-promoting agents, potentiates and/or promotes progression to full malignant phenotype. (edu.lb)
  • Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
  • The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
  • Growing evidence suggests that the interaction between the genomic/epigenomic aberrations in cancer cells and the surrounding microenvironment, composed of immune and stromal cells, contributes to the development of tumor invasion via mechanisms such as the so-called "angiogenic switch,"[3-5] creating multiple opportunities for therapeutic intervention. (cancernetwork.com)
  • Damage to DNA can include DNA strand breaks, point mutations due to DNA adducts, as well as alterations in methylation patterns leading to activation of oncogenes or inactivation of tumor suppressors. (biomedcentral.com)
  • Tumor-native ST6GAL1 promotes tumor cell behaviors such as invasion and resistance to cell stress and chemo- and radio-treatments. (nature.com)
  • The impact of this non-canonical extrinsic mechanism of ST6GAL1 on tumor cell pathobiology is not known. (nature.com)
  • We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
  • Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
  • Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)
  • However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
  • Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)
  • Ali MA, Choy H, Habib AA, Saha D. SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. (famri.org)
  • Isoforms of Wilms' tumor suppressor gene (WT1) have distinct effects on mammary epithelial cells. (famri.org)
  • Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer. (cancer-genetics.org)
  • Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). (medscape.com)
  • 3) that were divided into two major clusters corresponding to the main phases observed during the preadipocyte culture: proliferation and differentiation. (biomedcentral.com)
  • Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
  • Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
  • Therefore, growth of adipose tissue includes the hypertrophy of already existing adipocytes and the proliferation and differentiation of new ones from MSCs. (biomedcentral.com)
  • Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation. (avivasysbio.com)
  • Disease models for GERD, BE, GVHD, and ulcerative colitis based on three-dimensional human cell and tissue culture systems that recapitulate in vivo growth and differentiation in inflammatory-associated microphysiological environments would enhance our understanding of disease progression and improve our ability to test for disease-prevention strategies. (biomedcentral.com)
  • 3. Neurogenesis and neuronal differentiation: Zinc is essential for the development of new neurons from neural stem cells during the process of neurogenesis. (health11news.com)
  • It has been demonstrated that it affects brain plasticity and cognitive function by influencing the proliferation and differentiation of neural stem cells into adult neurons. (health11news.com)
  • This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. (cancer-genetics.org)
  • The effect of tested chemicals on the cells was measured using metabolic activity assay (WST-1), DNA synthesis assay (BrdU), protein synthesis assay (Brilliant Blue) and apoptosis (caspase-3 activity). (nih.gov)
  • IM combined with IR can synergistically inhibit the proliferation, apoptosis, clonogenesis, invasion, migration and cell cycle of GIST cells. (researchsquare.com)
  • PIk1 depletion induced apoptosis, as indicated by the appearance of subgenomic DNA in fluorescence-activated cell-sorter (FACS) profiles, the activation of caspase 3, and the formation of fragmented nuclei. (uky.edu)
  • Erikson, Raymond L. / Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells . (uky.edu)
  • Lipopolysaccharide (LPS) treatment was found to trigger BV‑2 cell migration, inflammation and neuronal apoptosis. (spandidos-publications.com)
  • After Foxc1 was overexpressed, the cognitive dysfunction of mice that underwent CLP surgery was improved, with the expression of IκBα also increased, microglial cell migration, the expression of p65, IL‑1β and TNF‑α and neuronal apoptosis were all decreased in vivo and in vitro , which were in turn reversed by the inhibition of IκBα in vitro . (spandidos-publications.com)
  • Cisplatin is an interstrand DNA crosslinker, interfering with mitosis as well as initiating the apoptosis response of the DNA damage response pathway [27]. (thetechnoant.info)
  • Moreover, apoptosis and senescence were augmented and recovery from treatment-induced DNA damage was delayed. (biomedcentral.com)
  • MCF-7, a p53+/+ cell line, was more sensitive to apoptosis than T47D, a p53-/- cell line. (jouwweb.nl)
  • Treatment of MCF-7 cells with pifithrin α, an inhibitor of p53, reversed Triphala's effects and, with similar observations in other cell lines, confirms the role of p53 in Triphala-induced apoptosis. (jouwweb.nl)
  • In some cell lines, Triphala-induced apoptosis was linked to phosphorylation of p53 at Ser-15 and ERK at Thr-202/Tyr-204. (jouwweb.nl)
  • A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
  • In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
  • STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. (thermofisher.com)
  • DNA damage occurred in PIk1-depleted cells and inhibition of ATM strongly potentiated the lethality of PIk1 depletion. (uky.edu)
  • Predicated on our outcomes from the in vitro research, we claim that inhibition of HDAC10 might potentiate the response to platinum-based therapy in ovarian cancer. (thetechnoant.info)
  • This is reinforced by Lactobacilli through the production of hydrogen peroxide (H 2 O 2 ), bacteriocins and biosurfactants, as well as the inhibition of the physical attachment of pathogens to the epithelium by competitive exclusion and the promotion of the engulfment and degradation of infected epithelial cells (autophagy). (frontiersin.org)
  • In contrast with neonatal cardiomyocytes, angiotensin II potentiated DNA synthesis and induced cell cycle regulated gene expression in AT-1 cardiomyocytes, and this activity was mediated by the angiotensin II type-1 receptor. (elsevierpure.com)
  • Fukuda, K & Izumo, S 1998, ' Angiotensin II potentiates DNA synthesis in AT-1 transformed cardiomyocytes ', Journal of Molecular and Cellular Cardiology , vol. 30, no. 10, pp. 2069-2080. (elsevierpure.com)
  • The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic. (sagepub.com)
  • Extracellular ATP shows synergistic enhancement of DNA synthesis when combined with agents that are active in wound healing or as neurotransmitters. (sagepub.com)
  • Pemetrexed is a folic acid antagonist that inhibits the synthesis of precursor nucleotides, whereas cisplatin directly induces DNA adducts, the repair of which is dependent on sufficiently high nucleotide levels. (biomedcentral.com)
  • MTA is a folic acid antagonist inhibiting the synthesis of precursor purine and pyrimidine nucleotides required for DNA and RNA synthesis. (biomedcentral.com)
  • Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. (cancerindex.org)
  • In several cancer cell lines, Triphala and its ingredients inhibited DNA synthesis, decreasing replication and proliferation. (jouwweb.nl)
  • More than 300 enzymes, including those involved in DNA synthesis, protein synthesis, and cell division, depend on zinc as an essential component. (health11news.com)
  • 2. Enzymatic activity: Zinc functions as a cofactor for many enzymes involved in brain metabolism, DNA synthesis, and the creation of neurotransmitters. (health11news.com)
  • We further statement that NTS analogs potentiate the effects of epidermal growth element (EGF) on hepatocyte DNA replication and cell proliferation. (bioshockinfinitereleasedate.com)
  • We found that ATP potentiated the ability of FGF2 to stimulate expression of cyclin D1, a regulator of cell cycle entry, as well as cyclin A, a regulator of DNA replication. (sagepub.com)
  • These findings suggest that signaling by P2Y receptors, most likely of the purine/pyrimidine subtype, enhance the ability of FGF2 to stimulate entry into a new cell cycle, as well as DNA replication, by an ERK-dependent mechanism, whereas signaling by P2X receptors, possibly the P2X7 subtype, inhibits FGF2-induced mitogenesis in astrocytes. (sagepub.com)
  • Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
  • Although MCC was initially named for the Merkel cell due to histologic and physiologic similarities between MCC and Merkel cells, the cellular progenitor of MCC has been a heavily debated question. (wikipedia.org)
  • Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
  • Oxidative stress is caused by the generation of reactive oxygen and nitrogen species that are part of the normal inflammatory response, but are also capable of damaging cellular DNA, protein, and organelles. (biomedcentral.com)
  • In normal cells, glucose participates in cellular energy production through glycolysis as well as through its complete catabolism via the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). (hindawi.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Adusumilli PS, Chan MK, Hezel M, Yu Z, Stiles BM, Chou TC, Rusch VW, Fong Y. Radiation-induced cellular DNA damage repair response enhances viral gene therapy efficacy in the treatment of malignant pleural mesothelioma. (famri.org)
  • Increased production of urate may be caused by increased nucleoprotein turnover in hematologic conditions (eg, lymphoma, leukemia, hemolytic anemia) and in conditions with increased rates of cellular proliferation and cell death (eg, psoriasis, cytotoxic cancer therapy, radiation therapy). (msdmanuals.com)
  • Immune cells can potentiate oxidative stress, and fibroblasts have the capacity to contribute to advanced growth and proliferation of the epithelium and any resultant cancers. (biomedcentral.com)
  • However, others have argued that MCC likely derives from an epithelial precursor cell due to its frequent presence in mixed tumors including epithelial neoplasms such as squamous cell carcinoma. (wikipedia.org)
  • While epithelial cells are not typically found in the dermis, hair follicles include epithelial cells that have been shown to have oncogenic potential, and have therefore been proposed as a possible site for a MCC precursor. (wikipedia.org)
  • Inflammation initiated by an immune response targets epithelial cells, leading to cytotoxic effects, and is a key driver of several disease conditions in the gastrointestinal (GI) tract [ 1 ]. (biomedcentral.com)
  • Interestingly, a cell population was identified that displayed an epithelial-to-mesenchymal transition (EMT) and which had a stem cell phenotype. (biomedcentral.com)
  • We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. (molvis.org)
  • Pterygium epithelial cells (PECs) were cultured in keratinocyte serum-free defined medium to examine the expression of IPO13 and K17. (molvis.org)
  • Importin 13 (IPO13), a member of the importin-β superfamily, was originally identified in the fetal rat lung and differentially expressed in cells of epithelial and mesenchymal origin. (molvis.org)
  • Aggressive breast cancer is a highly heterogeneous disease caused by a variety of distinct cell-intrinsic genetic alterations in mammary epithelial cells, leading to vastly heterogenic disease manifestation in individual patients and predominantly affecting patient prognosis and treatment options [ 14 ]. (nature.com)
  • Poly(ADP-ribose) polymerase inhibitors (PARPis) specifically target homologous recombination deficiency (HRD) cells and display good therapeutic effect in women with advanced-stage BRCA1/2-mutated breast and epithelial ovarian cancer (EOC). (biomedcentral.com)
  • High estrogen states, as seen during puberty and pregnancy, promote the preservation of a homeostatic (eubiotic) vaginal microenvironment by stimulating the maturation and proliferation of vaginal epithelial cells and the accumulation of glycogen. (frontiersin.org)
  • At puberty and during pregnancy, elevated levels of estrogen promote the maturation of and deposition of glycogen in vaginal epithelial cells. (frontiersin.org)
  • Glycogen from exfoliated and lysed epithelial cells is catabolized by α-amylase in the vaginal lumen to smaller polymers that are subsequently metabolized to lactic acid by Lactobacillus spp. (frontiersin.org)
  • Lactic acid and cytolysin produced by Lactobacilli stimulate the dissolution of epithelial cells by lysis and enhance the availability of glycogen. (frontiersin.org)
  • The same conditioned medium was unable to stimulate proliferation of mast cells expressing a defective receptor for SCF. (sacredheart.edu)
  • The medium was also unable to stimulate proliferation when it was preincubated with neutralizing antibodies specific for SCF. (sacredheart.edu)
  • and negative regulation of cell population proliferation. (nih.gov)
  • LY2606368 is a potent and selective ATP competitive inhibitor(IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase. (chemspider.com)
  • Open in a separate window Figure 1 Neurotensin pathway mRNA and protein expression in FL-HCC.Relative transcript expression levels of genes expressing neurotensin ((panel D) in FL-HCCs (T) versus paired, normal liver (N). (E) Immunoblotting demonstrates expression of NTS, NTSR1, NTSR2, and PCSK1 proteins in FL-HCCs (T) vs normal livers (N). HepG2 cells (H) were use as positive controls. (bioshockinfinitereleasedate.com)
  • Growth factors such as fibroblast growth factor (FGF), vascular endothelial cell growth factor (VEGF), and angiopoietin-1 (Ang1) are upregulated to stimulate angiogenesis, while downregulation of endogenous protein inhibitors (thrombospondin 1 and interferon) disrupts the balance of physiologic angiogenesis. (cancernetwork.com)
  • Because FGF2 and P2 purinergic receptors are coupled to extracellular signal regulated protein kinase (ERK), a key member of a signaling cascade that regulates proliferation, we also investigated the role of ERK in regulating cyclin expression induced by FGF2 and ATP. (sagepub.com)
  • The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. (cancerindex.org)
  • Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism including interaction with other cell proliferation-related factors: keratin 17 (K17), a lesional protein and a member of the type I keratins, and c-Jun, a protein of the activator protein-1 complex. (molvis.org)
  • Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. (famri.org)
  • The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. (cancer-genetics.org)
  • For neutrophils, a four-step mechanism is believed to coordinate recruitment of these inflammatory cells to sites of tissue injury and to the provisional extracellular matrix (ECM) that forms a scaffolding upon which fibroblast and endothelial cells proliferate and migrate, thus providing a nidus for reconstitution of the normal microenvironment5. (weeksmd.com)
  • Merkel-cell cancers tend to invade locally, infiltrating the underlying subcutaneous fat, fascia, and muscle, and typically metastasize early in their natural history, most often to the regional lymph nodes. (wikipedia.org)
  • Finally, the presence of B-cell surface markers on MCC in addition to the high correlation between MCC and B-cell lymphomatous cancers have also led to suggestions that MCC may share a progenitor with B-cells. (wikipedia.org)
  • Furthermore, tumour cells may usurp key mechanisms by which inflammation interfaces with cancers, to further their colonization of the host. (weeksmd.com)
  • Since cancer stem cells have been hypothesized to play a role in refractory/relapsing cancers, in the present work we investigated if autophagy could represent a constitutive cytoprotection mechanism for glioblastoma stem-like cells (GSCs) and if the modulation of autophagic process could affect GBM growth and survival. (nature.com)
  • The uncontrolled cell division of cancers makes DNA a primary target for disrupting the multiple processes needed to Pictilisib dimethanesulfonate sustain the proliferation. (thetechnoant.info)
  • Non-small cell lung cancer (NSCLC) accounts for approximately 85 % of all lung cancers, with the current standard regimen of care for NSCLC including chemotherapy with pemetrexed as a single agent or in combination with platinum-based agents, e.g. cisplatin. (biomedcentral.com)
  • The sialyltransferase ST6GAL1 that adds α2-6 linked sialic acids to N-glycans of cell surface and secreted glycoproteins is prominently associated with many human cancers. (nature.com)
  • To determine whether the potentiating effect of extracellular ATP involves cell cycle control mechanisms, we have measured the expression of cyclins that are induced in different phases of the cell cycle in primary cultures of rat cortical astrocytes. (sagepub.com)
  • However, ST6GAL1 is also released into the extracellular milieu and extracellularly remodels cell surface and secreted glycans. (nature.com)
  • We hypothesize that ST6GAL1 action is the combined effect of natively expressed sialyltransferase acting cell-autonomously within the ER-Golgi complex and sialyltransferase from extracellular origins acting extrinsically to remodel cell-surface glycans. (nature.com)
  • Extracellular ST6GAL1, present in cancer exosomes or the freely soluble recombinant sialyltransferase, compensates for insufficient intrinsic ST6GAL1 by boosting cancer cell proliferation and increasing invasiveness. (nature.com)
  • It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells , is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. (weeksmd.com)
  • In contrast, proliferating cells that sustain DNA damage and/or mutagenic assault (for example, initiated cells) continue to proliferate in microenvironments rich in inflammatory cells and growth/survival factors that support their growth. (weeksmd.com)
  • Hence, thanks to this complex mechanism, autophagy can provide energy supply to the cell and can represent a key cytoprotection mechanism allowing cell survival in unfavorable microenvironmental conditions such as those often found by cancer cells 7 . (nature.com)
  • CX40 knockdown in CRC cells reduced angiogenesis and mobility of HUVECs and blocked CRC cell proliferation, mobility, and survival. (bvsalud.org)
  • Restoration of NR3C1 suppressed the pro-angiogenic effect, proliferation and survival, and tumorigenic activity of CRC cells, which were, however, rescued by CX40 upregulation. (bvsalud.org)
  • MTA thereby interferes with the proliferation and survival of replicating cancer cells. (biomedcentral.com)
  • HO-1 in Cancer Cell Survival" Encyclopedia , https://encyclopedia.pub/entry/14608 (accessed December 06, 2023). (encyclopedia.pub)
  • We hypothesized that prolonged pretreatment with pemetrexed could be beneficial, as prior depletion of nucleotide pools could sensitize cancer cells to subsequent treatment with cisplatin. (biomedcentral.com)
  • Prolonged pemetrexed pretreatment for 48 h prior to cisplatin treatment maximally delayed long-term cell growth and significantly reduced the number of recovering clones. (biomedcentral.com)
  • Adaptation of the standard treatment schedule to include pretreatment with pemetrexed optimizes the anticancer efficiency of pemetrexed-cisplatin combination therapy, which correlates with a persistence of treatment-induced DNA damage. (biomedcentral.com)
  • In addition, a subpopulation of therapy resistant cells with EMT and cancer stem cell features was identified that was resistant to the standard treatment regimen but sensitive to pemetrexed pretreatment combined with cisplatin. (biomedcentral.com)
  • Angiotensin II has been shown to be mitogenic in various cell types. (elsevierpure.com)
  • In order to determine whether angiotensin II is simply a hypertrophic or hyperplastic growth factor for mitotically-potent cardiomyocytes, we analysed [ 3 H]-thymidine uptake and cell cycle-regulated gene expression using SV40 large T-transformed AT-1 cardiomyocytes. (elsevierpure.com)
  • Histone H1-kinase activity by cdc2 was also increased by angiotensin II, and peaked at 24-36 h, indicating that these changes were cell cycle dependent. (elsevierpure.com)
  • Double immunofluorescent photography showed that AT-1 cells incorporated BrdU, and expressed cdc2 by angiotensin II stimulation. (elsevierpure.com)
  • Stressors increase corticoreleasing hormone, adrenocorticoreleasing hormone, cortisol and prolactin and decrease prostaglandin E2 release and vasoconstriction induced/potentiated by angiotensin II, nitric oxide, acetylcholine and serotonin. (gremjournal.com)
  • We found that PIk1 depletion dramatically inhibited cell proliferation, decreased viability, and resulted in cell-cycle arrest with 4 N DNA content. (uky.edu)
  • Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. (thermofisher.com)
  • Ex vivo exposure of first trimester testes to CBD, THC, or CBD/THC [ratio 1:1] at 10 −7 to 10 −5 M altered testosterone secretion by Leydig cells, AMH secretion by Sertoli cells, and impacted testicular cell proliferation and viability as early as 72 h post-exposure. (biomedcentral.com)
  • MCC is sometimes mistaken for other histological types of cancer, including basal cell carcinoma, squamous cell carcinoma, malignant melanoma, lymphoma, and small cell carcinoma, or as a benign cyst. (wikipedia.org)
  • In a whole-genome sequencing in 17 Esophageal Squamous Cell Carcinoma cases and whole-exome sequencing in 71 cases, Song (2014), reported ASH1L alterations. (cancerindex.org)
  • In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. (weeksmd.com)
  • SOX9 promotes nasopharyngeal carcinoma cell proliferation, migration and invasion through BMP2 and mTOR signaling. (cancerindex.org)
  • Overexpression of SOX9 promoted NPC cell proliferation, migration and invasion. (cancerindex.org)
  • Connexin 40 (CX40) is one of the major gap junction proteins with the capacity in regulating cell-to-cell communication and angiogenesis. (bvsalud.org)
  • Conditioned medium of SW620 and HT29 cell lines was used to induce angiogenesis of human umbilical vein endothelial cells (HUVECs). (bvsalud.org)
  • Collectively, this study demonstrates that transcription activation of CX40 upon DNMT1-mediated NR3C1 DNA methylation potentiates angiogenesis in CRC. (bvsalud.org)
  • In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
  • Additionally, in vitro experiments have demonstrated that fibroblasts not only support Merkel cell polyomavirus (MCV) infection but can be induced into having a MCC phenotype by the expression of viral proteins. (wikipedia.org)
  • Nucleocytoplasmic transport is an essential phenomenon in eukaryotic cells controlled by the family of proteins called importins and exportins. (molvis.org)
  • This involves activation and directed migration of leukocytes (neutrophils, monocytes and eosinophils) from the venous system to sites of damage (Box 1), and tissue mast cells also have a significant role. (weeksmd.com)
  • These tumors also contain large numbers of mast cells, compared with the normal surrounding skin or tissue. (sacredheart.edu)
  • We have recently shown that stem cell factor (SCF), the gene product of the murine steel locus, can act as a chemoattractant for mast cells. (sacredheart.edu)
  • In this study, we investigated whether SCF might be involved in the recruitment and maintenance of mast cells in hemangiomas. (sacredheart.edu)
  • Experimental Design: Cultured endothelial cells derived from a murine hemangioma were compared with normal vascular endothelial cells for the ability to produce and release SCF, a mitogen for mast cells. (sacredheart.edu)
  • Results: Conditioned medium from hemangioma-derived endothelial cells stimulated the proliferation of cultured mast cells. (sacredheart.edu)
  • In addition, proliferative activity for mast cells could not be demonstrated in the conditioned medium of the normal endothelial cells, although Northern blot analysis indicated that both normal and hemangioma-derived endothelial cells express SCF mRNA. (sacredheart.edu)
  • Conclusions: Our data suggest that increased release of SCF is a property of hemangioma-derived endothelial cells that may account for the high numbers of mast cells observed in hemangioma tissue. (sacredheart.edu)
  • MCEMP1 potentiates KIT-mediated mast cell proliferation and chronic lung inflammation. (ccf.org)
  • The presence of hepatic cytochrome p470 and metabolism (e.G., reduction in ciprofloxacin liquid as small group of acridinylami- might be a func- is also potentiated by concomitant intake of this book uses the sodiumglucose cotransporter rhea complications. (stonecottagegardens.com)
  • We have previously shown that fish primary preadipocytes differentiate into mature adipocytes in vitro and that these cells represent a very helpful model system to study adipose tissue development in fish [ 5 , 6 ]. (biomedcentral.com)
  • A microglia‑mediated inflammation model was induced by LPS in BV‑2 microglial cells in vitro , whilst a SAE‑related cognitive impairment model was established in mice using cecal ligation and perforation (CLP) surgery. (spandidos-publications.com)
  • In vitro studies found dose- and time-dependent cytotoxic effects of Triphala extracts and constituents on a variety of cultured cancer cell lines, while equal concentrations did not harm cultured normal cells. (jouwweb.nl)
  • Although it is now clear that proliferation of cells alone does not cause cancer, sustained cell proliferation in an environment rich in inflammatory cells, growth factors, activated stroma, and DNA-damage-promoting agents, certainly potentiates and/or promotes neoplastic risk. (weeksmd.com)
  • Reverse transcriptase-polymerase chain reaction techniques were used to amplify the DNA sequence coding for the proteolytic cleavage site used for release of SCF. (sacredheart.edu)
  • Balusu R, Jaiswal AS, Armas ML, Kundu CN, Bloom LB, Narayan S. Structure/function analysis of the interaction of adenomatous polyposis coli with DNA polymerase beta and its implications for base excision repair. (famri.org)
  • In the last 8 decades, theories regarding carcinogenesis have progressed to include numerous pathways by which cells achieve immortality. (cancernetwork.com)
  • Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
  • To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
  • The origin of Merkel cells themselves is debated and proposed to be derived from neural crest cells or epidermal progenitors. (wikipedia.org)
  • MCC is similar to Merkel cells in its histological appearance (see below: Diagnosis) and shares many immunohistochemical markers with Merkel cells, including epidermal marker cytokeratin 20 and neuroendocrine markers synaptophysin and chromogranin A. Furthermore, the ion channel Piezo2 and transcription factor Atoh1, both specific to Merkel cells, are also expressed by MCC. (wikipedia.org)
  • NTS boosts proliferation in the current presence of epidermal growth aspect (EGF), and NTS-induced proliferation would depend on NTSR1 as well as the EGFR/MEK pathway. (bioshockinfinitereleasedate.com)
  • Forkhead box C1 (Foxc1) is a member of the forkhead transcription factor family that has been found to regulate in cell migration. (spandidos-publications.com)
  • The MCV is a small double-stranded DNA virus that is believed to contribute to the development of the majority of MCC. (wikipedia.org)
  • In this study, experimental studies were carried out to explore the action mechanism of the anti-cancer drug Azacitidine on the double-stranded DNA (dsDNA). (bvsalud.org)
  • Prolonged treatment with MTA induces replicative stress in the form of single stranded DNA, which, if not repaired, can lead to the formation of double stranded DNA breaks [ 4 ]. (biomedcentral.com)
  • Cell growth and colony formation as well as senescence induction were quantified after treatment. (biomedcentral.com)
  • Recognizing that inherited BRCA1/2 mutations are implicated in the cause of disease in a proportion of EOC patients, has led to the identification of the role of these genes in DNA repair. (biomedcentral.com)
  • Importantly, the elevated expression of Hg resistance-related genes in RHg was highly correlated with DNA hypomethylation in their putative promoter regions. (bvsalud.org)
  • Previously published work on DNA methylation status in GWI was reanalyzed focusing specifically on the predicted shared targets indicating significant changes in DNA methylation of the associated genes. (cdc.gov)
  • Merkel cells are highly specialized cells that act as pressure receptors in the epidermis. (wikipedia.org)
  • For instance, zinc can affect synaptic plasticity, learning, and memory processes by inhibiting N-methyl-D-aspartate (NMDA) receptors, potentiating α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, and modulating GABAergic transmission. (health11news.com)
  • In 1863, Virchow hypothesized that the origin of cancer was at sites of chronic inflammation, in part based on his hypothesis that some classes of irritants, together with the tissue injury and ensuing inflammation they cause, enhance cell proliferation1. (weeksmd.com)
  • proliferation and inflammation subside after the assaulting agent is removed or the repair completed. (weeksmd.com)
  • 3) therapeutic/vaccine development and stabilization, and (4) inflammation and immunity (host-pathogen standoff, programmed cell death, immune atlas of pregnancy and inflammation). (ccf.org)
  • Increased Stem Cell Factor Release by Hemangioma-Derived Endothelial C" by C. J. Meininger, Shannon Brightman et al. (sacredheart.edu)
  • Capillary hemangiomas, the most common tumors in young children, consist of proliferating capillary vessels and endothelial cells. (sacredheart.edu)
  • Immunoprecipitation and Western blot analysis of the conditioned media from hemangioma cells and normal endothelial cells demonstrated the 31,000 molecular weight SCF in hemangioma-conditioned medium only. (sacredheart.edu)
  • Results indicated that both normal and hemangioma-derived endothelial cells express the same transcript for SCF. (sacredheart.edu)
  • Because of the differences in physiology and prognosis between MCV+ and MCV- MCC (see below), however, some have suggested that these two subtypes of MCC may actually derive from different progenitor cells. (wikipedia.org)
  • Six weeks after DFP injection, the animals were euthanized and medial prefrontal cortex harvested for genome-wide DNA methylation analysis using high-throughput sequencing. (cdc.gov)
  • We used the recently developed vector-based small interfering RNA technique to specifically deplete PIk1 in cancer cells. (uky.edu)
  • Similarly, while Triphala increased intracellular reactive oxygen species (ROS) in some cancer cells compared with normal cells, pretreatment with antioxidants inhibited this effect. (jouwweb.nl)
  • In contrast to normal cells, most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactate fermentation, even in the presence of oxygen, a less efficient metabolism compared to a low rate of glycolysis followed by mitochondrial oxidation of pyruvate [ 2 ]. (hindawi.com)
  • Metabolic adaptations of cancer cells. (hindawi.com)
  • Glucose and glutamine are the 2 major substrates used by cancer cells. (hindawi.com)
  • Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective therapies are urgently needed. (cancerindex.org)
  • This theory suggests that exposure to dust particulates in the lung tissues provokes an inflammatory response, which then leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) by alveolar and interstitial macrophages, along with polymorphonuclear cells. (medscape.com)
  • In addition, autophagy interpheres with cell cycle progression, de facto exerting a cytostatic activity. (nature.com)
  • It is within the cell-autonomous context that ST6GAL1 involvement in cancer progression has been interpreted. (nature.com)
  • Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
  • It has been suggested that endogenous factors might contribute to the rapid progression of periodontal breakdown such as inappropriate regulation of enzymes, lipid mediators, collagen biosynthesis or T cell immunodeficiency. (bvsalud.org)
  • In addition, calcitriol has rapid effects that are independent of gene transcription regulation, which are defined as non-genomic effects and not mediated directly through steroid receptor-ligand-DNA interaction. (jcancer.org)
  • Infiltrating immune cells and stromal components of tissue including fibroblasts contribute to dynamic changes occurring in tissue related to disease development. (biomedcentral.com)
  • Factors involved in the development of MCC include the Merkel cell polyomavirus (MCPyV or MCV), a weakened immune system, and exposure to ultraviolet radiation. (wikipedia.org)
  • 3. Immune system performance: Zinc is essential for the immune system's smooth operation, including the growth and operation of immune cells including T cells, B cells, and natural killer cells. (health11news.com)
  • It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. (wikipedia.org)
  • Death of GSCs was apparently due to the iron dependent form of programmed cell death characterized by the accumulation of lipid peroxides called ferroptosis. (nature.com)
  • Plasminogen activator inhibitor-1 inhibits plasminogen activators and subsequent fibrinolysis potentiating thromboembolic effects. (gremjournal.com)
  • Cell Death Differ, 2023 May. (nih.gov)
  • 2023 Nature Cell Biology 25:92. (ccf.org)
  • Autophagy is a regulated mechanism of the cell that leads to the disassembly of unnecessary or dysfunctional components. (nature.com)
  • Although p53 is stabilized in PIk1-depleted cells, DNA damage also occurs in p53 -/- cells. (uky.edu)