Cell proliferation plant tumors. Medical search. Frequent questions

To further investigate the molecular mechanism by which the extract promoted apoptosis and inhibited the proliferation of the AML cells used, apoptotic protein expression was determined through western blots. (nih.gov)
This effect was mediated by DNA fragmentation and apoptosis, as revealed by Cell Death ELISA and dual Annexin V/PI staining. (nih.gov)
Our results indicated that AST inhibits cell proliferation through phase-specific cell cycle arrest and caspase-dependent apoptosis. (spandidos-publications.com)
We determined the possible contribution of apoptosis to the observed decrease in cell growth and found that three compounds, EGCG, kaempferol, and, in particular, punicic acid, induced DNA fragmentation after a 24 h treatment, at concentrations in the 10-100 μM range. (nih.gov)
Additionally, JIB extract induced B16/F10 cell apoptosis via the caspase cascade. (medsci.org)
The results demonstrated that JIB extract combined with cisplatin enhanced the inhibition of cell growth, proliferation, and survival through the obstruction of cell cycle progression and AKT/mTOR and MAPK signaling as well as the induction of cell apoptosis. (medsci.org)
For example, paeonol inhibits proliferation and induces apoptosis of bladder cancer cells in vitro and in vivo by regulating the phosphorylation expression of phosphatidylinositol 3-kinase and protein kinase B (PKB/AKT). (cjphysiology.org)
Apoptosis (necessary programmed cell death) of the adenocarcinoma cells was increased. (naturalnews.com)
Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)
First, we found that GS-002 significantly inhibited cell proliferation and induced cell apoptosis in dose-dependent manners. (hindawi.com)
Furthermore, we found that GS-002 induced more cell apoptosis in ATF-3-overexpressing cells. (hindawi.com)
Polyphenols are written to be anti-cancer, anti-tumor cell proliferation, anti-apoptosis (cell death), anti-metastasis, and anti-inflammatory. (drhugulet.com)
This clinical cancer strategy incorporates advancements in cancer treatment based on a multi-approach to the disease that includes targeting apoptosis, immune cell activation, angiogenesis, restoration of cellular respiration, inhibition of inflammatory mediators, not mentioning some secondary factors such as intoxication, disturbed microbiome, and nervous disorders. (biobran.org)
WFA induced apoptosis, significantly reduced cell proliferation and inhibited migration of melanoma cells. (edu.au)
Further, cell death effect of ST was associated with induction of apoptosis. (biomedcentral.com)
In this investigation, the role of autophagy and apoptosis in Solanum nigrum fruit extract-induced cytotoxicity in MDA-MB-468, a triple negative breast cancer cell line was studied. (ijpsonline.com)
In addition, cell apoptosis was measured by double staining, DNA fragmentation and annexin V-fluorescein isothiocyanate binding assays. (ijpsonline.com)
These findings indicated that Solanum nigrum extract induced cell death in MDA-MB-468 cells by two distinct mechanisms, apoptosis and autophagy, and these findings further suggest a possibility that this extract could be used to treat triple negative breast cancer. (ijpsonline.com)
Solanum nigrum (SN) is a herb with anticancer effects such as destruction of tumor cell membrane, induction of apoptosis by NF-kappaB, caspase activation, nitric oxide production and inhibition of angiogenesis [ 3 ]. (ijpsonline.com)
A previous study reported that the extract of the whole plant of SN activated cell death in hepatoma cells through autophagy and apoptosis [ 7 ]. (ijpsonline.com)
Autophagy and apoptosis are two forms of programmed cell death, which are essential for cellular homeostasis. (ijpsonline.com)
Cytotoxicity, antiproliferative and apoptosis-inducing capacity of ACNVs against hepatoma carcinoma cell were assessed. (dovepress.com)
ACNVs were found to possess specific antitumor cell proliferation activity associated with an apoptosis-inducing pathway. (dovepress.com)
May induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation. (mannofit.com)
One type, known as apoptosis, results from cancer cells essentially committing suicide. (cancer.org)
If ginger can cause autophagic cell death in addition to apoptosis, it may circumvent resistance to conventional chemotherapy," says study author J. Rebecca Liu, M.D., assistant professor of obstetrics and gynecology at the U-M Medical School and a member of the U-M Comprehensive Cancer Center. (cancer.org)
Role of PDL-1 in NSCLC chemoresistance was assessed using CRISPR/Cas9 knockdown and various functional assays including MTT, cell invasion, sphere formation, and cell apoptosis. (cdc.gov)
Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)

The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) is a multifunctional tumour suppressor which binds a variety of factors that impinge on the proliferation, migration and invasiveness of cancer cells. (boku.ac.at)
Drs. Kim Vanderlinden and Ivana Vucenik describe what is presently known about how IP6 works to help normalize the rate of cell division, normalize cell physiology, enhance Natural Killer (NK) cells, increase tumor suppressor P53 gene activity, inhibit inflammation, and inhibit angiogenesis. (naturalnews.com)
These two important mechanisms of approaching cancer, principally through the clinical application of the P53 tumor suppressor gene and other apoptotic players that for the past 15 years have been included in my cancer strategy as a diagnostic, prognosis, and follow up treatment. (biobran.org)
We identified that repression of the tumour suppressor TRIM16 diminished WFA cytotoxicity, suggesting that TRIM16 was in part responsible for the cytotoxic effects of WFA in melanoma cells. (edu.au)

Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
Infiltration versus metastasis is one of the most characteristic biological properties of tumors [ 5 ]. (hindawi.com)
Generally, it is believed that there are four main pathways between tumor invasion and metastasis, including local invasion, blood, lymphatic, and seeding metastasis [ 6 ]. (hindawi.com)
In addition to these four pathways, tumors can undergo infiltration around nerve fibers and metastasis along nerves, that is, perineural invasion (PNI), which refers to the phenomenon of perineural invasion by tumor cells filling the perineurial space, wrapping around nerves in a continuous concentric sheath-like pattern, infiltration, and metastasis of extension along nerves around nerve fibers or into perineurium within the perineurium [ 7 ]. (hindawi.com)
Tumors can become hazardous and even fatal when they spread to the cancer through a process known as metastasis. (biomedcentral.com)
However, the impact of M6P/IGF2R on tumour invasion and metastasis is so far only poorly understood. (boku.ac.at)
Future studies will aim at the identification of these anti-invasive M6P-modified protein(s) followed by a comprehensive assessment of their involvement in tumour invasion and metastasis. (boku.ac.at)
In Dr. A.M. Shamsuddin's review of findings in Nutrition and Cancer vol. 55, he states that in addition to its role in cancer prevention and control of experimental tumor growth, progression and metastasis, IP6 possesses other significant benefits, such as the ability to enhance the immune system, function as a natural antioxidant, prevent calcification and kidney stone formation, lower elevated serum cholesterol, and reduce pathological platelet activity. (naturalnews.com)
To this end, we here employ an integrated multi-omics approach comprising unbiased and quantitative glycomics and glycoproteomics applied to a cohort of resected primary tumor tissues from OSCC patients with (n = 19) and without (n = 12) lymph node metastasis. (bvsalud.org)
While all tumor tissues displayed relatively uniform N-glycome profiles suggesting overall stable global N-glycosylation during disease progression, altered expression of six sialylated N-glycans was found to correlate with lymph node metastasis. (bvsalud.org)
Chemotherapy is a treatment modality that uses chemical drugs to stop the proliferation, infiltration and metastasis of cancer cells until they are finally eliminated. (targetmol.com)

Melanoma is the most malignant and lethal skin tumor owing to its high metastatic ability and the incidence of melanoma has been increasing over the years. (medsci.org)
Colorectal cancer (CRC), including colon cancer and rectal cancer, is one of the most common malignant tumors. (biomedcentral.com)
According to the latest global cancer statistics 2018, CRC has risen to the rank third of malignant tumors and when it comes to the cancer mortality, CRC ranks second, ahead of the stomach cancer and liver cancer [ 3 ]. (biomedcentral.com)
In addition to the arresting of cell proliferation, this process also induces the differentiation of malignant cells. (naturalnews.com)
As previous known, the more differentiated the malignant cells, the less aggressive and dangerous is the cancer. (naturalnews.com)
WFA showed selective toxicity to melanoma cells compared to non-malignant cells. (edu.au)
Malignant tumour cells are able to invade nearby tissues and spread to other parts of the body. (nutters.com)
The first sign that a malignant tumour has spread (metastasized) is often swelling of nearby lymph nodes, but cancer can metastasize to almost any part of the body. (nutters.com)
Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
First described in 1848, MM is characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein (M protein). (medscape.com)

The tumor size and the number of proliferating cells were reduced in the tumor tissues obtained from the formononetin-treated group. (spandidos-publications.com)
Langerhans cell histiocytosis (LCH) describes a group of syndromes that share the common pathologic feature of infiltration of involved tissues by Langerhans cells. (medscape.com)
Western blotting was employed to determine NGF level in PC and paracarcinoma tissues and in PC cell lines as well as pancreatic ductal epithelial cells. (hindawi.com)
NGF level was preeminently higher in PC tissues and cell lines than in paracarcinoma tissues and normal pancreatic epithelial cell lines. (hindawi.com)
CREG is a glycoprotein expressed in most mammalian tissues and cell types. (boku.ac.at)
While altered protein glycosylation is regarded a trait of oral squamous cell carcinoma (OSCC), the heterogeneous and dynamic glycoproteome of tumor tissues from OSCC patients remain unmapped. (bvsalud.org)
A method of analysis of eight flavones using high-performance liquid chromatography (HPLC)-diode array detection mass spectrometry in root and aerial tissues of the medicinal plant Scutellaria baicalensis was developed by Christopher RH et al (2005).2 The identity of the analytes was confirmed using retention time UV-visible and mass spectral comparisons to commercial standards. (webmedcentral.com)
Our bodies are made up of millions of cells, grouped together to form tissues and organs such as muscles and bones, the lungs and the liver. (nutters.com)
Our finding of BLV in human tissues indicates a risk for the acquisition and proliferation of this virus in humans. (cdc.gov)

The current study evaluates the anti-cancer and anti-proliferative properties of Annona cherimola ethanolic leaf extract (AELE) on Acute Myeloid Leukemia (AML) cell lines cultured in vitro (Monomac-1 and KG-1). (nih.gov)
To reveal that the NGF-TrkA signaling pathway was closely associated with PC PNI, in vitro neuroinvasion model was established by using MiaPaCa-2 cells via coculturing DRG cells in Matrigel. (hindawi.com)
In this study, we investigated how TSPAN12 regulates OC cell proliferation both in vitro and in vivo and found that it contributed to tumor proliferation and poor prognosis in this disease through cyclin and cyclin-dependent kinase (CDK) pathways. (molcells.org)
We therefore undertook a preliminary screening study of the three IFBTS seed oils in vitro using human colon adenocarcinoma cells (Caco-2), a commonly used gastrointestinal cell line, and human embryonic kidney (HEK-293), an epithelial immortalised cell line. (iiarjournals.org)
Our data showed that NBT suppressed CCA cell proliferation in vitro and in vivo . (ijbs.com)
They hypothesized that IP6 would inhibit the cell growth rate of Barrett's adenocarcinoma in vitro. (naturalnews.com)
They hypothesized that IP6 would significantly inhibit cell growth of cutaneous melanoma in vitro. (naturalnews.com)
They hypothesized that IP6 would significantly inhibit cell growth and increase the apoptotic rate of pancreatic cancer in vitro. (naturalnews.com)
In this study, we examined the antitumor effects of GS-002 in human hepatoma Hep3B and HepG2 cells in vitro . (hindawi.com)
These results suggest prominent in vitro anti-proliferative and pro-apoptotic effects of ST in MDA-MB-231 cells. (biomedcentral.com)

Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
Moreover, TSPAN12 accelerated mitotic progression by controlling cell cycle. (molcells.org)
Aberrant glycolytic reprogramming is involved in lung cancer progression by promoting the proliferation of non-small cell lung cancer cells. (cjphysiology.org)
1 , 2 In recent years, mammalian cell-derived exosomes (a type of extracellular vesicle) have been widely used in the field of biomedicine, including diagnosis, regulation of disease progression and drug delivery. (dovepress.com)

Subsequently, we used a model of neuroinvasion in nude mice to assess the effect of NGF in vivo on tumor nerve invasion as well as on nociceptive transmission. (hindawi.com)
In vivo tumorigenesis experiments, Tanezumab markedly alleviated nerve invasion of PC cells as well as relieved nociceptive conduction in animal models. (hindawi.com)
In this scenario, the identification of molecular biomarkers of response and the use of a multimodal in vivo imaging approach represent unique tools for better understanding tumor features, with the final goal of identifying a cluster of patients that are potential responders to personalized medicine. (mdpi.com)
In vivo distribution of ACNVs was detected in healthy and tumor-bearing mice after scavenger receptors (SRs) blockade. (dovepress.com)
In vivo antitumor activity and toxicity were evaluated in Hep G2 cell xenograft model. (dovepress.com)
In vivo antitumor results showed that PEGylated ACNVs could significantly inhibit tumor growth without side effects. (dovepress.com)
In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
In vivo experiments were conducted using a co-implantation xenograft mouse model with live cell imaging and immunohistochemistry. (cdc.gov)

[8] Nonetheless, whether paeonol participates in the regulation of A549 cell (human non-small cell lung cancer cell) proliferation through other signaling pathways remains to be elucidated. (cjphysiology.org)
Gene enrichment analysis revealed that these lncRNA-related mRNAs are associated with cell adhesion, collagen adhesion, cell differentiation, and mainly enriched in ECM-receptor interaction and PI3K-Akt signaling pathways. (biomedcentral.com)
According to Dr. Shamsuddin, when IP6 is administered it is rapidly taken into the cells and dephosphorylated to lower inositol phosphates, which further affect signal transduction pathways. (naturalnews.com)
From the study, it was found that the combination treatment significantly inhibited both AR and PI3K/Akt pathways in LAPC-4 cells while also inhibiting several oncogenic microRNAs compared to the control. (lifeseasons.com)
The induction of ATF-3 expression was mediated by mitogen-activated protein kinase (MAPK) signaling pathways in GS-002-treated cells. (hindawi.com)
Although some beneficial phytochemicals might function solely as antioxidants, it is becoming clear that many of the beneficial chemicals in vegetables, herbs, plants and fruits evolved as toxins (to dissuade insects and other predators) that, at subtoxic doses, activate adaptive cellular stress-response pathways in a variety of cells including neurons. (psychosocialsomatic.com)
Examples of such 'preconditioning' or 'neurohormesis' pathways include those involving cell-survival signaling kinases, the transcription factors NRF2 and CREB, and histone deacetylases of the sirtuin family. (psychosocialsomatic.com)

The exaggerated immune response to repeated inhalation of these particles leads to infiltration and proliferation of activated pulmonary macrophages and lymphocytes, resulting in lymphocytic alveolitis and bronchiolitis with noncaseating granulomas. (cdc.gov)

Considerable evidence has been provided that CREG is involved in the control of cell growth and differentiation. (boku.ac.at)
Animal-derived oils and purified fatty acids, but not indigenous fruit-tree-derived seed oils, have been used to study cell growth and differentiation. (iiarjournals.org)
In addition to being found in plants, IP6 is contained within almost all mammalian cells, where it is important in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation. (naturalnews.com)

ATF-3 induces DNA synthesis and expression of cyclin D1 in hepatocytes [ 21 ] and is involved in serum-induced cell proliferation as a target gene of c-myc [ 10 ]. (hindawi.com)

Cholangiocarcinoma (CCA) is a type of hepatobiliary cancer characterized by uncontrolled cell proliferation, with a poor prognosis and high mortality. (ijbs.com)

Cells deprived of steroid hormones were exposed to increasing concentrations (1-100 μM) of pomegranate compounds in the presence of 0.1 nM dihydrotestosterone (DHT), and the inhibition of cell growth was measured by WST-1 colorimetric assay after a 4 day exposure. (nih.gov)
The antimicrobial activity of the plant extract is based on both the elimination and inhibition of pathogenic processes by the microorganisms [ 8 ]. (biomedcentral.com)
Furthermore, pre-treatment of CA rescues the proliferation inhibition induced by a sub-IC 50 dose of paclitaxel (PTX), an anticancer drug. (tmu.edu.tw)
In MDA-MB-231 cells, ST caused a significant dose-dependent cell growth inhibition by 31- 63% (p ≤ 0.0001) in 48 h and 40-50% (p ≤ 0.0001) in 72 h. (biomedcentral.com)

These cells carry somatic mutations of the BRAF gene and/or NRAS, KRAS , and MAP2K1 genes. (medscape.com)
In our search for potentially tumour-suppressive M6P/IGF2R interaction partners, we identified an essentially uncharacterized M6P-modified protein previously named Cellular Repressor of E1A-stimulated Genes (CREG). (boku.ac.at)
Targeted therapy drugs are used to target specific genes and proteins of cancer cells to precisely identify and attack specific types of cancer cells. (medsci.org)
The expression levels of autophagy-related genes, Lc3 and Beclin1 increased in cells treated with 1.5 mg/ml of Solanum nigrum extract. (ijpsonline.com)
Genes inside each cell order it to grow, work, reproduce and die. (nutters.com)

Our results showed that the treatment with A. cherimola ethanolic leaf extract exhibited an inhibitory effect on the proliferation of both cancer cell lines used in a dose- and time-dependent manner, with no toxic effects on normal mononuclear cells (MNCs) isolated from human bone marrow. (nih.gov)
Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. (spandidos-publications.com)
Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
In this study, we investigated the growth inhibitory, antiandrogenic, and pro-apoptotic effects of 13 pure compounds found in the pomegranate in androgen-dependent LNCaP human prostate cancer cells. (nih.gov)
In conclusion, punicic acid, the main constituent of pomegranate seed (70-80%), exhibited potent growth inhibitory activities in androgen-dependent LNCaP cells, which appear to be mediated by both antiandrogenic and pro-apoptotic mechanisms. (nih.gov)
Cell counting kit 8, 5-Bromo-2-deoxyuridine, 5-ethynyl-2'-deoxyuridine (EdU) incorporation, flow cytometry analysis, western blotting and seahorse XFe24 extracellular flux analyzer assays showed that paeonol had a significant inhibitory effect against A549 cell proliferation and glycolysis. (cjphysiology.org)
As published in Oncology Research , February 2008, researchers reported that IP6 was shown to have significant inhibitory effects against a variety of primary tumors. (naturalnews.com)
As published in Journal of Surgical Research , June 2005, researchers reported that IP6 has been found to have significant inhibitory effects against a variety of primary tumors including breast and colon. (naturalnews.com)

Scientific evidence of the pharmacological activity of the plant strengthens the traditional application of plants. (biomedcentral.com)
NBT could inhibit CCA proliferation, and the pharmacological activity of NBT in CCA was attributed to its direct binding to GSK3β. (ijbs.com)
Andrographis paniculata plant extract is known to possess a variety of pharmacological activities. (rainwoodbio.com)

Four compounds, epigallocatechin gallate (EGCG), delphinidin chloride, kaempferol, and punicic acid, were found to inhibit DHT-stimulated cell growth at concentrations of 10 μM and above. (nih.gov)
GC-MS analysis demonstrated the presence of several biologically active compounds such as Clindamycin, Phytol, Octanoic acid, and Stigmasterol which might be the reason for the therapeutic properties of the plant. (biomedcentral.com)
Identifying novel antimicrobial agents from plant-based compounds may result in anti-microbial drugs effective against the resistant strains. (biomedcentral.com)
Plants contain various active compounds like polyphenols, coumarins, alkaloids, terpenoids and peptides that possess antimicrobial activity [ 2 ]. (biomedcentral.com)
However, plant seed oils at times contain liposoluble toxic compounds, such as tumor-promoting phorbol esters found in Jatropha curcas seed oil ( 10 ), the toxic gossypol found in crude cotton ( Gossypium hirsutum ) seed oil ( 11 ) and the encephalopathy-causing Neem seed oil ( 12 ). (iiarjournals.org)
Previous studies reported that ATF-3 was induced by treating cells with antitumorigenic compounds [ 14 - 18 ] and a phosphoinositide 3-kinase inhibitor [ 19 ]. (hindawi.com)
Terpenes, like the myrcene terpene , are natural aromatic compounds that produce unique scents and flavors in cannabis plants. (homegrowncannabisco.com)
Cannabis plants are made up of different organic compounds, and terpenes are one of the prime constituents. (homegrowncannabisco.com)
They're naturally occurring compounds located in the trichomes of female marijuana plants . (homegrowncannabisco.com)
CWO primarily consist of a mixture of structurally related terpenes, a class of chemical compounds composed of isoprene units with distinct aromatic qualities that plants generate for defensive purposes. (biorxiv.org)
however, mechanisms through which these bioactive compounds act on epithelial cells have not been identified. (biorxiv.org)
Phytochemicals include compounds with various biological properties (i.e. antioxidant, antiproliferative, DNA repair) which have presumably evolved, in part, to allow plants to cope with environmental challenges including exposure to radiation and toxins, and defense against pests and infectious agents (Tuteja et al. (psychosocialsomatic.com)
Sixty one plants reputed to have anti-fertility activity were tested on female Sprague-Dawley rats, in order to isolate active compounds with a potential for use in human fertility regulation. (who.int)
Five plants, namely, calotropis gigantea calotropis procera, plumeria rubra, Juniperus sabina and Jatropha curcas were identified as highly promising leads from which anti-fertility compounds may be isolated. (who.int)

The anti-proliferative effect of A. cherimola ethanolic leaf extract was evaluated via cell viability assay. (nih.gov)
Finally, NBT showed an anti-proliferative effect in tumor-bearing mice with no hepatotoxicity. (ijbs.com)
Their combination, however, synergistically enhanced the anti-proliferative effect with a stronger effect on the androgen receptor wild-type LAPC-4 cells vs. the mutated LNCaP cells. (lifeseasons.com)

Besides, 12% of patients have second- or third-degree skin reactions that are sensitive to light, and about 18% of patients develop cutaneous squamous-cell carcinoma and keratoacanthoma or occurred at the same time [ 6 ]. (medsci.org)
SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)

However, potentially erroneous characterization of cytotoxicity and cell proliferation can arise if verification of baseline interaction of test article with method employed is neglected. (cdc.gov)
The current investigation aimed to demonstrate how interpretation of results from several standard cytotoxicity and proliferation assays vary in dependence on contributions from the pentose phosphate pathway (PPP). (cdc.gov)
Non-tumorigenic Beas-2B cells were treated with graded concentrations of benzo[a]pyrene (B[a]P) for 24 and 48h prior to cytotoxicity and proliferation assessment with commonly used MTT, MTS, WST1, and Alamar Blue assays. (cdc.gov)
These results demonstrate differential sensitivity of standard cytotoxicity assessments on the PPP, thus (1) decoupling 'mitochondrial activity' as an interpretation of cellular formazan and Alamar Blue metabolism, and (2) demonstrating the implicit requirement for investigators to sufficiently verify interaction of these methods in routine cytotoxicity and proliferation characterization. (cdc.gov)

These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
MiaPaCa-2 and CFPAC-1 cells were treated with 100 ng/ml of NGF or the NGF inhibitor Tanezumab for 24 h, CCK-8 and Transwell assays were employed to test cell proliferation, invasion, and migration, respectively. (hindawi.com)
NGF promoted MiaPaCa-2 and CFPAC-1 cell invasion and migration, while Tanezumab treatment showed the opposite results. (hindawi.com)
TrkA blocking-up could restrain NGF induced PC cell migration and neural invasion. (hindawi.com)

The reduction in tumor volume as well as pro-apoptotic and anti-proliferative effects in HT-29 nude mice xenograft are comparable to those produced by 5-FU. (spandidos-publications.com)

In laboratory studies, researchers found ginger caused ovarian cancer cells to die. (cancer.org)
Further, the way in which the cells died suggests ginger may avoid the problem common in ovarian cancer of cells becoming resistant to standard treatments. (cancer.org)
The ginger powder was dissolved in solution and applied to ovarian cancer cell cultures. (cancer.org)
Ginger induced cell death in all the ovarian cancer cell lines tested. (cancer.org)
Ginger is effective at controlling inflammation, and inflammation contributes to the development of ovarian cancer cells. (cancer.org)
In multiple ovarian cancer cell lines, we found that ginger induced cell death at a similar or better rate than the platinum-based chemotherapy drugs typically used to treat ovarian cancer," says Jennifer Rhode, M.D., a gynecologic oncology fellow at the U-M Medical School. (cancer.org)

Its pro-apoptotic effect was assessed through Cell Death ELISA and dual Annexin V/PI staining. (nih.gov)
All the data presented in our study show that the terpene-rich A. cherimola ethanolic leaf extract exhibits an anti-proliferative and pro-apoptotic effect on the AML cell lines used. (nih.gov)
The extract caused apoptotic and necrotic cell death in lung cancer cells. (biomedcentral.com)
The study shows the cytotoxic and apoptotic activity in A549 cancer cell line. (biomedcentral.com)
Researchers concluded that IP6 decreased cellular growth of these cells by pro-apoptotic mechanisms. (naturalnews.com)
Several main apoptotic indicators were found in GS-002-treated cells, such as the cleaved forms of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP). (hindawi.com)

extract (JIB extract) for melanoma cells. (medsci.org)
In addition, AKT/mTOR signaling and MAPK signaling were inhibited by JIB extract to suppress melanoma cell growth and proliferation. (medsci.org)
Collectively, our results indicate that JIB extract showed anti-tumor effects and synergized with cisplatin against B16/F10 cells, indicating the possibility of JIB extract to be developed as adjuvant therapy for melanoma. (medsci.org)
Melanoma cell lines were cultured and treated with IP6. (naturalnews.com)
In this study, we evaluated the efficacy of Withaferin A (WFA), derived from the medicinal plant Withania Somnifera, as a novel therapeutic agent for the treatment of melanoma. (edu.au)
Together our data indicates that WFA has potent cytopathic effects on melanoma cells through TRIM16, suggesting a potential therapeutic application of WFA in the disease. (edu.au)

RIP assay was performed to validate NGF and miR-21 binding ability in MiaPaCa-2 cells. (hindawi.com)
MTT assay was performed to determine cell proliferation. (farmaciajournal.com)

Andrographolide also enhanced the α production and CD marker expression, resulting in increased cytotoxic activity of lymphocytes against cancer cells, which may contribute for its indirect anticancer activity. (rainwoodbio.com)
Different concentrations of Solanum nigrum extract showed cytotoxic effect on MDA-MB-468 cells. (ijpsonline.com)

However at the relatively small doses ingested by humans that consume the plants, the phytochemicals are not toxic and instead induce mild cellular stress responses. (psychosocialsomatic.com)

But sometimes the instructions get mixed up, causing the cells to form lumps or tumours, or spread through the bloodstream and lymphatic system to other parts of the body. (nutters.com)
Rapid blood and lymphatic spread and breast tumor emboli are the main features ofIBC 4 . (bvsalud.org)
check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)
Silencing PDL-1 expression suppressed CAFs' ability to promote stem cell-like properties and invasiveness of lung cancer cells, favoring chemoresistance. (cdc.gov)

Mechanistically, NGF could upregulate TDE-miR-21-5p levels, and DRG cells took up TDE to activate the Warburg effect and stimulate nociceptor gene expression. (hindawi.com)

These phytochemicals have different mechanisms of action that can either stimulate protective enzymes or directly prevent cell proliferation. (lifeseasons.com)
Phytochemicals are secondary plant metabolites and have been used for centuries throughout the world in traditional cures and herbal remedies, and as ayurvedic and homeopathic medicines in India. (biomedcentral.com)
Phytochemicals are chemicals of plant origin. (psychosocialsomatic.com)
Phytochemicals (from Greek phyto, meaning "plant") are chemicals produced by plants through primary or secondary metabolism. (psychosocialsomatic.com)
From an evolutionary perspective, the noxious properties of such phytochemicals play an important role in dissuading insects and other pests from eating the plants. (psychosocialsomatic.com)
Phytochemicals serve numerous functions in plants and contribute to their color, flavor, smell and texture. (psychosocialsomatic.com)
In these ways, neurohormetic phytochemicals such as resveratrol, sulforaphanes and curcumin might protect neurons against injury and disease by stimulating the production of antioxidant enzymes, neurotrophic factors, protein chaperones and other proteins that help cells to withstand stress. (psychosocialsomatic.com)

Here we used two human lung cancer cell lines, A549 and H1299, to clarify the role of CA in cancer cell proliferation. (tmu.edu.tw)
Here, we investigated whether paeonol regulates the proliferation and glycolytic reprogramming via ACADM with m6A modification in A549 cells (human non-small cell lung cancer cells). (cjphysiology.org)
We also showed that the m6A reader YTH domain containing 1 plays an important role in m6A-modified ACADM expression, which is negatively regulated by paeonol, and is involved in A549 cell proliferation and glycolytic reprogramming. (cjphysiology.org)
These results indicated the central function of paeonol in regulating A549 cell glycolytic reprogramming and proliferation via m6A modification of ACADM. (cjphysiology.org)
[7] Notably, a recent study also illustrated that the proliferation and motility of A549 cells can be suppressed by paeonol by disrupting signal transducer and activator of transcription 3 (STAT3)/nuclear factor kappa B (NF-κB) subunit signaling. (cjphysiology.org)
Here, we evaluated the efficacy of ST on three different human cancer cell lines including skin epidermoid carcinoma A431 cells, lung epithelial carcinoma A549 cells and breast adenocarcinoma MDA-MB-231. (biomedcentral.com)
Whereas similar ST treatments moderately inhibited the growth of A549 cells by up to 13% (p ≤ 0.05) in 48 h and 14% (p ≤ 0.05-0.0001) in 72 h. (biomedcentral.com)

According to the review, the volatile oils and extracts of these herbs and plants were noted to inhibit the synthesis of mevalonate, which help lessen tumor growth and cholesterol synthesis. (lifeseasons.com)
There is a growing interest in the use of natural products like herbs, spices and plant extracts in the human food and animal feed industries. (webmedcentral.com)
The experiments were carried out with crude plant extracts in the first instance. (who.int)
In this method the isotonic contractions of the isolated uterine horn of the oestrogenised rat were observed in the presence of various plant extracts. (who.int)
Since several plant extracts resulted in a loss of appetite ,the effect of a reduced feed intake on reproduction in laboratory animals was also investigated. (who.int)

Terpenes, like the myrcene terpene, aren't unique to cannabis plants and are also found in other flora, particularly conifers. (homegrowncannabisco.com)
Although cannabis was a medicinal plant for thousands of years, its medical use was suppressed and banned throughout most of the 20th century. (greenmedinfo.com)
The three major illicit drugs derived from plants were then (at the beginning of my career), and still are, opium, coca and cannabis. (greenmedinfo.com)
1975 Munson shows anti cancer effects of cannabis in Lewis Lung Tumors. (greenmedinfo.com)
CBD, an active compound derived from the cannabis plant, has been studied extensively for its potential therapeutic benefits in various health conditions. (sugarloop.net)

The intra- and intertumor heterogeneity of cell types and gene mutations as well as the complexity of the microenvironment contribute to limiting the efficacy of the current therapeutic options for high grade glioma. (mdpi.com)
However, unlike other oncogenic retroviruses, deltaretroviruses have an additional region, tax (trans-activating region of the X gene), which has regulatory functions and is oncogenic to host cells. (cdc.gov)

These studies have revealed that the interaction between M6P/IGF2R and M6P-modified ligands is more important for tumour suppression than its capacity to limit the bioavailability of IGF2. (boku.ac.at)
The suppression of Caco-2 and HEK-293 cell proliferation by K. africana, M. zeyheri and X. caffra seed oils suggest a potential antiproliferative effect of these tree seed oils on the two cell lines. (iiarjournals.org)

The vascular endothelial growth factor (VEGF) is a well characterized angiogenic factor known to stimulate angiogenesis within a tumor ( 1 ). (spandidos-publications.com)
It is rich in organic matter, water and fertility on the strong soil growth, in the lack of organic matter, poor ventilation clay, its roots will be stunted, plant growth is weak, commodity is poor. (wikipedia.org)
Cancer cells obtain a growth advantage through uncontrolled cell proliferation ( Hanahan and Weinberg, 2011 ), which may be caused by mutations that help them adapt to the microenvironment through selective pressure. (molcells.org)
One of the major standards of seed quality is the 1000 grain weight, which is effective on sprouting, seed potential, seedling growth, and plant performance. (researchgate.net)
The trypan blue dye exclusion method was used to determine cell growth 48-hours after oil treatment. (iiarjournals.org)
All three tree seed oils suppressed both Caco-2 and HEK-293 cell growth in a dose-dependent manner. (iiarjournals.org)
K. africana oil significantly suppressed Caco-2 cell growth compared to HEK-293 cell growth at all oil concentrations, whereas M. zeyheri and X. caffra seed oils significantly suppressed HEK-293 and Caco-2 cell growth, only at a concentration of 80 mg/l. (iiarjournals.org)
The growth assay showed that CA moderately promoted the proliferation of the lung cancer cells. (tmu.edu.tw)
NewsTarget) Three recent studies have confirmed the role of inositol hexaphosphate (IP6) in cancer prevention and control of experimental tumor growth. (naturalnews.com)
The phytosterols in the plant are used to stimulate natural hair growth. (lifeseasons.com)
On the other hand, ATF-3 is rapidly induced in cells treated with growth stimulators such as serum and growth factors [ 20 ]. (hindawi.com)
Myrcene, like other terpenes, plays an integral role in the growth, propagation, and survival of every marijuana plant. (homegrowncannabisco.com)
Cell growth assay, cell cycle analysis, FACS, JC-1 staining, annexin V staining and immunoblotting were used to study the efficacy of ST on cancer cells. (biomedcentral.com)
ST (30-90 μM) treatments for 48 h and 72 h did not show any significant effect on cell growth and death in A431 cells. (biomedcentral.com)
1. **Anti-cancer effects:** Some studies indicate that CBD may have anti-tumor properties by inhibiting the growth and proliferation of cancer cells. (sugarloop.net)
While CBD shows promise in potentially inhibiting the growth of cancer cells, it is not a cure for myeloma. (sugarloop.net)
They generally have biological activity in the plant host and play a role in plant growth or defense against competitors, pathogens, or predators. (psychosocialsomatic.com)

[ 2 , 3 ] Pulmonary Langerhans cell histiocytosis is considered a reactive proliferation of dendritic Langerhans cells to chronic tobacco-derived plant proteins resulting from incomplete combustion, but it can also occur as a tumor-like systemic disease in children. (medscape.com)
Interestingly, cytokines from type-2 innate immune cells, such as M2 macrophages or D2 dendritic cells exhibit a protective effect on both types of diabetes. (biobran.org)

JIB extract induced cell cycle arrest at the G 0 /G 1 phase and decreased cyclin and cdk protein expressions. (medsci.org)

Formononetin is a novel herbal isoflavonoid isolated from Astragalus membranaceus, a medicinal plant that possesses antitumorigenic properties. (spandidos-publications.com)

Among its different constituents, Astragalus polysaccharides have been most widely studied particularly for their immunopotentiating properties, such as stimulation of murine B cell proliferation and cytokine production ( 6 ). (spandidos-publications.com)
We have now demonstrated that reconstitution of functional M6P/IGF2R expression in receptor-deficient murine cancer cells severely compromises their invasive potential. (boku.ac.at)

ABSTRACT Diet has not been investigated as a potential risk factor for head and neck squamous cell carcinomas in the Syrian Arab Republic. (who.int)
Head and neck squamous cell carcino- receive treatment. (who.int)
Global burden of HPV-attributable squamous cell carcinoma of the anus in 2020, according to sex and HIV status: A worldwide analysis. (who.int)

These results indicate that the M6P/IGF2R status influences the metastatic propensity of cancer cells in a decisive manner. (boku.ac.at)

It is a systemic treatment and is a common clinical method for treating tumors. (targetmol.com)
Hypersensitivity pneumonitis, also known as extrinsic allergic alveolitis, is an uncommon non-immunoglobulin E (IgE), T-helper cell type 1 (Th1)-mediated inflam- matory pulmonary disease with systemic symptoms resulting from repeated inhalation and subsequent sensitization to a large variety of aerosolized antigenic organic dust particles. (cdc.gov)

Biosynthesis and intracellular trafficking of secretory and lysosomal/vacuolar proteins, glycosylation and other post-translational protein modifications as determinants of protein structure and function, catalytic properties and physiological functions of proteases and glycosylation enzymes, proteolysis and its pathological and biotechnological relevance, recombinant expression of biotherapeutics in plants, plant membrane protein biochemistry. (boku.ac.at)
Autophagy, the type II cell death, is a physiological mechanism involving degradation of intracellular damaged proteins and organelles into membrane vacuoles. (ijpsonline.com)
Exosomes are a type of membrane vesicles secreted by living cells. (dovepress.com)

In myeloma, these plasma cells become cancerous, multiplying rapidly and crowding out healthy blood cells. (sugarloop.net)

Biological characterization of oils using of cells in culture has largely focused on animal-derived oils and purified fatty acids while little if any investigations have been carried out on seed oils from IFBTs. (iiarjournals.org)
Moreover, it has been used in traditional oriental medicines for treating various kinds of tumors and is believed to have various biological activities [ 5 ]. (ijpsonline.com)

Paeonol, as a traditional Chinese medicine, plays a critical role in multiple cancer cell proliferation and inflammation. (cjphysiology.org)

Lectins are a protein found in plant foods that bind to carbohydrates. (plantnutritionwellness.com)
ST caused G0/G1 cell cycle arrest which was accompanied by a decrease in CDK4 and cyclin D1, and an increase in p21/Cip1and p27/Kip1 protein levels. (biomedcentral.com)

Androgen-dependent LAPC-4 and LNCaP prostate cancer cells were treated with low doses of arctigenin and quercetin for a period of 48-hours. (lifeseasons.com)

While exploring the molecular changes associated with strong ST efficacy in breast cancer cells, we observed that ST induced cell cycle arrest as well as cell death. (biomedcentral.com)

In the last years higher attention focused on the role of immunoregulation both in the insulin production by β-cell of Langerhans-islets and in the insulin sensitivity (resistance) of insulin receptors. (biobran.org)
Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)
One of the hallmarks of breast cancer is resistance of tumor cells to cell death. (ijpsonline.com)
The lymphoid organs house phagocytic cells and lymphocytes, which play essential roles in body defense and resistance to disease. (nutters.com)

Enhanced immunity and antioxidant properties also contribute to tumor cell destruction. (naturalnews.com)

The harmful effects of chemicals and the side effects of chemical drugs on human health have a widely focused global attention on herbal drugs and medicinal plants. (researchgate.net)
In this study, we determined the effects of the Kigelia africana, the Mimusops zeyheri and the Ximenia caffra seed-oil on cell proliferation in culture. (iiarjournals.org)
As it is a naturally occurring substance already found in human cells, there are no side effects. (naturalnews.com)
More recently, there has been a considerable interest in secondary plant metabolites because of their potential preventative effects on chronic diseases including cancer. (biomedcentral.com)
Several studies have been conducted in cell cultures and animal models, demonstrating the anti-cancer effects and pain management potential of CBD. (sugarloop.net)

Antibacterial activity was evaluated by using disc and agar diffusion methods and the anti-cancer effect of the rose flower extract (RE) was examined using MTT assay in lung cancer cell line. (biomedcentral.com)
In breast cancer, ATF-3 enhances cancer cell-initiating features [ 22 ] and is associated with activation of the canonical Wnt/ β -catenin pathway [ 23 ]. (hindawi.com)

CONCLUSION: Our results show that PDL-1-positive CAFs modulate stem cell-like properties of NSCLC cells by secreting elevated HGF, thereby promoting chemoresistance. (cdc.gov)

In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
Screening of herbal plants for various therapeutic properties is the hour as it shows promising activity. (biomedcentral.com)
Several modern pharmaceuticals are made from herbs and medicinal plants based on the properties of the traditional knowledge of the plant. (biomedcentral.com)
Some plants exhibit therapeutic characteristics in only a few parts due to the distribution of secondary metabolites, while the remaining parts of the plant may be devoid of any such properties. (biomedcentral.com)
Caco-2 cells are known to form tight junctions ( 13 - 14 ), have structural properties similar to those of ileal enterocytes ( 15 ) and are hence useful models as they mimic the gastrointestinal tract. (iiarjournals.org)
A review was conducted concerning the different types of plants that retain immune-stimulating and anti-tumor properties. (lifeseasons.com)
The present paper is an overview on scientifically established and published phytopharmacological properties of the plant. (webmedcentral.com)
This can be described as a plant extract that has anti-cancer properties that slow down the proliferation of tumor cells. (beaumontmedicaltransport.org)
Vitamin A's antioxidant properties make it essential for the maintenance of skin cells, mucus membranes, etc. (mannofit.com)
RESULTS: We demonstrated that chemotherapy-stimulated CAFs promoted tumorigenic and stem cell-like properties of NSCLC cells, which contribute to their chemoresistance. (cdc.gov)

3)Resisting tumor, protecting liver and owning cholagogue function. (rainwoodbio.com)
The root of the plant has qualities that aid in bile stimulation, liver cell regeneration as well as in supporting healthy uric acid levels. (lifeseasons.com)

Definitive diagnosis, if necessary, can be made by identification of Langerhans cell granulomas in lung biopsy samples acquired by video-assisted thoracoscopy. (medscape.com)
Our study suggested that the pro-survival effect of CA on PTX-treated lung cancer cells is mediated through a NF-κB signaling pathway. (tmu.edu.tw)
This study provides valuable insight into the chemopreventive efficacy and associated molecular alterations of ST in breast cancer cells whereas it had only moderate efficacy on lung cancer cells and did not show any considerable effect on skin cancer cells. (biomedcentral.com)
In this study, we investigated programmed death-ligand 1 (PDL-1) as a potential biomarker for CAF-induced chemoresistance and evaluated its role and the underlying mechanisms of chemoresistance in non-small cell lung cancer (NSCLC). (cdc.gov)

We have investigated its subcellular localization in mammalian cells, Drosophila melanogaster and Arabidopsis thaliana and found that intracellular CREG resides in all these organisms within lysosomes or its functional equivalents. (boku.ac.at)

These antigens include organic dusts containing bacteria, fungi,4 animal or plant proteins, or low-molecular-weight chemicals. (cdc.gov)

Anatomy7

Organisms5

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes10

Apoptosis28

Suppressor4

Metastasis12

Malignant10

Tissues9

Vitro10

Progression4

Vivo8

Pathways7

Infiltration1

Differentiation3

Induces1

Poor prognosis1

Inhibition4

Genes5

Inhibitory8

Pharmacological3

Compounds14

Anti-proliferative effect3

Cutaneous squamous-cell carc2

Cytotoxicity4

Invasion4

Xenograft1

Ovarian cancer6

Apoptotic6

Melanoma6

Assay was performed2

Cytotoxic2

Humans1

Lymphatic3

Invasiveness3

Mechanistically1

Phytochemicals7

A5497

Extracts5

Cannabis5

Gene2

Suppression2

Growth17

Dendritic2

Extract induced1

Medicinal plant1

Murine2

Squamous cell3

Metastatic1

Systemic2

Membrane3

Cancerous1

Biological2

Inflammation1

Protein2

Prostate1

Cycle arrest1

Resistance4

Immunity1

Effects5

Cancer cell2

Conclusion1

Properties10

Liver2

Lung4

Mammalian1

Proteins1