AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureHumanitiesInformation Science
Liver RegenerationRegenerationHepatectomyCell ProliferationLiverHepatocytesNerve RegenerationCell DivisionLiver DiseasesLiver NeoplasmsCells, CulturedSignal TransductionLiver TransplantationProliferating Cell Nuclear AntigenRNA, MessengerApoptosisCell DifferentiationBone RegenerationCell CycleLiver CirrhosisMice, Inbred C57BLTime FactorsHepatocyte Growth FactorGene Expression RegulationBromodeoxyuridineMice, KnockoutImmunohistochemistryCell Line, TumorStem CellsFatty LiverRats, Sprague-DawleyCarbon TetrachlorideDrug-Induced Liver InjuryRats, WistarRats, Inbred F344STAT3 Transcription FactorBlotting, WesternReverse Transcriptase Polymerase Chain ReactionLiver Function TestsDNAOrgan SizeMice, TransgenicLiver Failure, AcuteMicrosomes, LiverGene ExpressionCell SurvivalCell LineCell MovementDisease Models, AnimalLiver Neoplasms, ExperimentalPhosphorylationMitotic IndexKi-67 AntigenModels, AnimalUp-Regulation2-AcetylaminofluoreneHyptisCarbon Tetrachloride PoisoningMolecular Sequence DataInterleukin-6Guided Tissue RegenerationTranscription FactorsMitochondria, LiverCyclin D1Growth SubstancesDown-RegulationDose-Response Relationship, DrugRNA, Small InterferingAlanine TransaminaseBase SequenceDNA-Binding ProteinsMitogensTransfectionMice, Inbred BALB CEpithelial CellsTumor Cells, CulturedLiver CirculationCarcinoma, HepatocellularThymidineFlow CytometryRats, Inbred StrainsLymphocyte ActivationCell CountGene Expression ProfilingWound HealingKupffer CellsMitosisProto-Oncogene Proteins c-aktGene Expression Regulation, NeoplasticGene Expression Regulation, DevelopmentalRNA InterferenceCyclin-Dependent Kinase Inhibitor p21Cytochrome ReductasesModels, BiologicalTranscription, GeneticLiver Cirrhosis, ExperimentalCell Growth Processesalpha-FetoproteinsHepatic Stellate CellsThioacetamide
DifferentiationMesenchymal stemApoptosisTissueEpithelial cellsPromoted cell proliferation and migrationMicroenvironmentPartial hepatectomyHepatocyteExtracellular matrixTumorInduces proliferationVivoHepatocytesVitroCirrhosisSuppressesHepatic regenerationStem cellAssaysTissuesMigrationFibrosisRegulatesAbstractProgressionPathwayProgenitor cellsMetabolismInvolvesAdhesionGrowthHumansCardiomyocyteTransplantationOrganIntrahepaticBoneAbility to regenerateInjuryNanofiber scaffoldsMechanismsInhibitionAdultGeneMarkedlyDiseasesCytokinesMalignancyCharacterizationMetabolicBilePortal veinPhysiologyMiceRatsScaffoldsStimulateHypothesisReceptorsMetastasisPathwaysModulatesSpleenGenesImmunohistochemistryHepatocellular carcinoma
Differentiation17
  • During tissue homeostasis and regeneration epithelial cells must balance proliferation, cell death and differentiation to maintain a functional organ. (ed.ac.uk)
  • Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes. (joplink.net)
  • These biomembranes or scaffolds constitute a support for osteoblastic adhesion and proliferation, but also microenvironment for stem cells' chemotactism and differentiation [ 1 ]. (hindawi.com)
  • Thus, the strategy of functionalization of nanofibers by nanoreservoirs of BMP-2 or BMP-7 showed a great efficiency for bone regeneration and increased the differentiation of MSCs (mesenchymal stem cells), accelerating the tissue regeneration in vivo [ 9 , 10 , 13 , 14 ]. (hindawi.com)
  • performed in vivo lineage tracing studies to determine that expression of the keratin 15 promoter distinguishes a distinct basal stem cell population that is capable of self-renewal, proliferation, and differentiation into squamous-lineage cells. (jci.org)
  • Vitamin A and its derivative retinoic acid regulate various aspects of cell behavior as growth, differentiation, and proliferation. (ima.org.il)
  • In CaCo-2 colonic epithelial cells, the expression of this gene increases with cell differentiation. (aacrjournals.org)
  • Basic fibroblast growth factor treatment markedly improved the proliferation, differentiation, and hepatocyte growth factor expression ability of adipose tissue-derived mesenchymal stem cells. (sct4me.com)
  • We propose these results as a confirmation that apoptotic cells can control surrounding cells fate and as a reference database to explore novel apoptotic functions in animals, including those related to migration and differentiation. (biomedcentral.com)
  • Accumulating evidence in many metazoans suggest that apoptotic cells can emit caspase-dependent signals to their neighbours, modulating their fate (survival/death, differentiation or proliferation) or behaviour (migration) [ 12 , 13 ]. (biomedcentral.com)
  • The expression of osteogenesis-related gene was increased, which demonstrated that released BMP-2 could effectively induce the cell sheet osteogenic differentiation in vitro. (dovepress.com)
  • It is a complex and dynamic process to form a continuous construct via the cells' adhesion, proliferation, differentiation, and extracellular matrix (ECM) deposition on a scaffold. (dovepress.com)
  • Furthermore, its delivery in to the human brain enhances cell viability of grafted neural stem cells, and mementos their differentiation for an endothelial-like phenotype [12]. (antiviralbiologic.com)
  • In vitro TNFa induces proliferation and migration but suppresses differentiation of myoblasts. (cdc.gov)
  • Conclusions: This study showed that an osteoblastic cell lineage may be obtained from human bone marrow derived from adherent cells, and that the presence of the rhBMP-4 seems to have an effect during the first stages of differentiation only. (bvsalud.org)
  • Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
  • Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
Mesenchymal stem13
  • Different sources of living cells are described, as mesenchymal stem cells (MSCs), adipose-tissue derived stem cells, skin derived multipotent stem cells, or oral cavity MSCs, presenting compatible immunophenotype or morphology [ 2 , 3 ]. (hindawi.com)
  • To determine the effects of the presence of valproic acid (VA), Wharton's jelly mesenchymal stem cells (MSC) are seeded to the two scaffolds. (asme.org)
  • mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. (springer.com)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • Rat adipose tissue-derived mesenchymal stem cells were infused into cirrhosis rats with or without splenectomy, followed by the assessment of the in vivo distribution of stem cells and pathological changes. (sct4me.com)
  • Recent studies show that adipose tissue-derived mesenchymal stem cells have potential clinical applications. (sct4me.com)
  • Adipose tissue-derived mesenchymal stem cells were infused into carbon tetrachloride-induced hepatic fibrosis rats through caudal vein. (sct4me.com)
  • Although adipose tissue-derived mesenchymal stem cells infusion alone slightly ameliorated liver functions and suppressed fibrosis progression, basic fibroblast growth factor-treatment significantly enhanced the therapeutic effect in association with elevated hepatocyte growth factor expression. (sct4me.com)
  • Mechanism investigation revealed that co-culture with adipose tissue-derived mesenchymal stem cells activated c-jun N-terminal kinase-p53 signaling in hepatic stellate cell and promoted apoptosis. (sct4me.com)
  • Basic fibroblast growth factor treatment enhanced the therapeutic effect of adipose tissue-derived mesenchymal stem cells, and secretion of hepatocyte growth factor from adipose tissue-derived mesenchymal stem cells plays a critical role in amelioration of liver injury and regression of fibrosis. (sct4me.com)
  • PEI-al nanocomposites carrying BMP-2 gene could efficiently transfect bone marrow mesenchymal stem cells. (dovepress.com)
  • Our results suggested that PEI-al nanocomposites efficiently deliver the BMP-2 gene to bone marrow mesenchymal stem cells and that BMP-2 gene-engineered cell sheet is an effective way for promoting bone regeneration. (dovepress.com)
  • Undifferentiated mesenchymal stem cells are pluripotent cells that can differentiate into various phenotypes and are a source of osteogenic Cells 1,2 . (bvsalud.org)
Apoptosis16
  • Proliferation, apoptosis, and retinoic acid receptors were evaluated by histology and immunohistochemistry in bile duct cells and hepatocytes. (ima.org.il)
  • The amount of vitamin A in the rat diet did not affect detectably ductal cell apoptosis. (ima.org.il)
  • STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. (thermofisher.com)
  • Some lncRNAs affect the growth and development of breast cancer by regulating cell proliferation and apoptosis, and others are involved in invasion and metastasis and drug resistance of breast cancer [ 6 ]. (jcancer.org)
  • In addition, hepatocyte growth factor induced hepatic stellate cell apoptosis via the c-jun N-terminal kinase-p53 pathway. (sct4me.com)
  • Furthermore, co-culture with adipose tissue-derived mesenchymal stem cell led to induction of hepatic stellate cell apoptosis and enhanced hepatocyte proliferation. (sct4me.com)
  • Apoptosis is a caspase regulated cell death present in all metazoans defined by a conserved set of morphological features. (biomedcentral.com)
  • A well-described function of apoptosis is the removal of excessive cells during development and homeostasis. (biomedcentral.com)
  • In contrast to the apoptotic function of cell elimination, this new role of apoptosis is not well understood but seems caspase-dependent. (biomedcentral.com)
  • To deepen our understanding of apoptotic functions, it is necessary to work on a biological model with a predictable apoptosis pattern affecting cell fate and/or behaviour. (biomedcentral.com)
  • Apoptosis is also implicated in homoeostasis by fine-tuning the balance between cell death and proliferation like in gonad size control in rodents [ 11 ]. (biomedcentral.com)
  • While the function of cell elimination by apoptosis is highly documented, apoptosis seems to have a broader morphogenetic function that goes beyond cells elimination. (biomedcentral.com)
  • Apoptotic-induced proliferation was reported in several organisms, such as in the cnidarian Hydra , where apoptosis promotes proliferation of adjacent cells through emission of Wnt3 signalling in a caspase-dependant manner during head regeneration [ 14 ]. (biomedcentral.com)
  • Evaluating the capacity of caspases to affect gene expression and influence fate and/or behaviour of cells adjacent to apoptosis is the first fundamental step to better characterise this new function in animals. (biomedcentral.com)
  • Role of PDL-1 in NSCLC chemoresistance was assessed using CRISPR/Cas9 knockdown and various functional assays including MTT, cell invasion, sphere formation, and cell apoptosis. (cdc.gov)
  • Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)
Tissue25
  • However, the underlying mechanisms explaining the interactions between regenerating liver tissue and tumour cell proliferation remain unclear. (nih.gov)
  • On the other hand, chronic radiation injury is caused by injury to the less mitotically active vascular endothelial and connective tissue cells. (medscape.com)
  • We are particularly interested in the role of the Wnt pathway in these processes and are currently working on both canonical and non-canonical Wnt signalling to define how these pathways regulate tissue architecture, using the adult liver and cancers of the adult liver as a models for these studies. (ed.ac.uk)
  • Bone regeneration using electrospun nanofibers' implant has the following objectives: bone neoformation induction with rapid healing, reduced postoperative complications, and improvement of bone tissue quality. (hindawi.com)
  • The clinical purpose of these methods is the reparation or guided regeneration of damaged tissue, in our case, jaw bone affected by genetical diseases. (hindawi.com)
  • The esophageal epithelium experiences a high rate of cellular renewal that supports rapid tissue regeneration in response to injury. (jci.org)
  • This week in the JCI , a study led by Anil Rustgi at the University of Pennsylvania identifies keratin 15 as a marker for a subpopulation of proliferative stem cells in the esophagus that are indispensible for maintaining homeostasis as well as regenerating tissue following injury. (jci.org)
  • Although wild-type mice displayed normal morphology 15 days after injury, tissue regeneration remained incomplete in mice lacking keratin 15 + cells. (jci.org)
  • Among the research projects heading to the ISS are crystal growth, Earth science and technology research , and even tissue regeneration, which is where those mice come in. (inverse.com)
  • Part of the Tissue Regeneration-Bone Defect (Rodent Research-4) study, the mice have undergone "surgical resection to create artificial segmental femoral defects. (inverse.com)
  • It's all part of a project to find out if "reduced gravity induces cell proliferation and propagation," which scientists know to be "a potent environment for tissue regeneration. (inverse.com)
  • Scaffolds for tissue regeneration must present a viable microenvironment for the living cells to adhere, proliferate, and exhibit the necessary tissue function. (asme.org)
  • Biocompatible materials, such as polycaprolactone (PCL), have been used extensively to fabricate scaffolds using electrospinning technique, to study cell compatibility and to evaluate cell functionality for nerve tissue engineering applications. (asme.org)
  • The liver has a rare ability to regenerate and replace damaged or missing tissue. (vetscite.org)
  • Indeed, the very factors that cause liver injury initiate a reparative process in the residual liver that includes the induction of cytoprotective mechanisms, deletion of mortally wounded cells, repair of less damaged survivors, liver cell proliferation to replace the cells that died, the deposition of new matrix, and tissue remodeling to restore normal hepatic mass and architecture. (duke.edu)
  • Additionally, conventional chemical adhesives lack the ability to adapt to dynamic changes in the wound environment, hindering tissue regeneration. (news-medical.net)
  • H19 gene is reactivated and up-regulated during tissue regeneration or tumorigenesis [ 11 , 12 ]. (jcancer.org)
  • We obtained the rat liver tissue gene datasets (GSE63742) collected following partial hepatectomy (PH) from the Gene Expression Omnibus (GEO) of the National Center for Biotechnology Information (NCBI), from which, this study screened the late stage LR samples (7 days post-PH) using the R/Bioconductor packages for the identification of differentially expressed genes (DEGs). (jomh.org)
  • Splenectomy enhances the therapeutic effect of adipose tissue-derived mesenchymal stem cell infusion oncirrhosis rats. (sct4me.com)
  • Basic fibroblast growth factor-treated adipose tissue-derived mesenchymal stem cell infusion to ameliorate liver cirrhosis via paracrine hepatocyte growth factor. (sct4me.com)
  • Here, we investigated the effect of basic fibroblast growth factor-treated adipose tissue-derivedmesenchymal stem cells infusion on a liver fibrosis rat model and elucidated the underlying mechanism. (sct4me.com)
  • Recently, stem cell sheet has been an emerging strategy in bone tissue engineering. (dovepress.com)
  • Liver growth aspect (LGF) is a hepatic mitogen purified some years back that promotes proliferation of different cell types as well as the regeneration of damaged tissue, including mind tissue. (antiviralbiologic.com)
  • Recent studies also show that LGF promotes proliferation of different cell types [5]C[9] as well as the regeneration of broken cells and tissue, including human brain tissue. (antiviralbiologic.com)
  • of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)
Epithelial cells6
  • In the liver, this regulation requires the constant integration of signals by epithelial cells from non-epithelial, niche cells, which includes inflammatory cells and fibroblasts. (ed.ac.uk)
  • In cancer, these interactions become deregulated and epithelial cells can either be regulated independent of their microenvironment or the niche becomes permissive to tumour formation. (ed.ac.uk)
  • These findings indicate that keratin 15 + progenitors give rise to a population of squamous epithelial cells that are critical to recovery from injury and disease. (jci.org)
  • Vitamin A deficiency was found to be associated with enhanced proliferation of bile duct epithelial cells following CBD [1] ligation. (ima.org.il)
  • Ductular proliferation is often used to describe the appearance of biliary epithelial cells in the portal tracts of diseased livers. (idsemergencymanagement.com)
  • #Akkermansia utilises mucin as a nutritional source and degrades it into SCFA acetate , which acts as a substrate for other beneficial bacteria to produce butyrate, an energy source for the intestinal epithelial cells. (metabiom.org)
Promoted cell proliferation and migration1
Microenvironment2
  • These include injury-induced changes in the hepatic microenvironment, the ability of surviving liver cells and/or their progenitors to proliferate, and a temporary suspension of homeostatic mechanisms that normally couple cell proliferation to programmed cell death. (duke.edu)
  • During the course of hepatocyte necrosis, an intense accumulation of neutrophils is often observed within the liver microenvironment. (mdpi.com)
Partial hepatectomy3
  • Recent clinical and experimental studies have indicated that cellular and molecular mechanisms associated with liver regeneration after partial hepatectomy may have a proliferative effect on occult micrometastases and circulating tumor cells and are thus responsible for recurrent disease. (nih.gov)
  • Liver architecture remodeling following partial hepatectomy (PHx) involves the formation of a complex network of liver sinusoids through which the blood flows. (biu.ac.il)
  • A previous report indicates that exposure to TCDD suppresses hepatocyte proliferation in a mouse model of liver regeneration induced by 70% partial hepatectomy (PH). (boisestate.edu)
Hepatocyte10
  • It has already been established that a transient increase of transforming growth factor β1 (TGF-β1) in the liver promotes fibrosis with the formation of extracellular matrix (ECM) components and suppresses hepatocyte proliferation. (vin.com)
  • MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
  • Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
  • Over 7 days, FPH 2 induced hepatocyte doublings at a rate that is consistent with reported liver regeneration kinetics in vivo . (axonmedchem.com)
  • Stromal cell-derived factor-1 and hepatocyte growth factor expression were also investigated in splenectomized cirrhosis patients and rats. (sct4me.com)
  • Stromal cell-derived factor-1 and hepatocyte growth factor levels after splenectomy were increased in patients and rats. (sct4me.com)
  • Splenectomy prior to cell infusion enhanced the therapeutic effect of stem cells on cirrhosis, which involved upregulation ofstromal cell-derived factor-1 and hepatocyte growth factor after splenectomy. (sct4me.com)
  • Hepatocyte proliferation in the remnant liver was measured based on the incorporation of a thymidine analog, bromodeoxyuridine. (boisestate.edu)
  • Depletion of NK cells did not restore hepatocyte proliferation in TCDD-treated mice, indicating that NK cells are not required for the attenuation of liver regeneration by TCDD. (boisestate.edu)
  • Hence, exposure to TCDD suppresses in vivo hepatocyte proliferation by a mechanism that does not involve NK cells or enhanced production of IFN-γ. (boisestate.edu)
Extracellular matrix2
Tumor9
  • Inhibits the proliferation of a number of tumor cell lines. (joplink.net)
  • We found that mutation of the NF2 tumor suppressor gene in the mouse liver led to a dramatic overproliferation of liver stem cells - the cells that contribute to the liver's remarkable ability to regenerate," says Andrea McClatchey, PhD, of the MGH Center for Cancer Research, who led the study. (vetscite.org)
  • Previous research also indicated that liver stem cells may be the source of some tumors in animals, and suggested that the tumor suppressor gene NF2 may help prevent tumor development. (vetscite.org)
  • The current study was designed to investigate the role of NF2 and merlin in the fetal and adult mouse liver, including possible involvement with tumor development. (vetscite.org)
  • Mice that did not die from a lack of functioning liver cells soon developed the two major types of liver cancer, and the fact that stem cell overgrowth preceded tumor development strongly suggested that the undifferentiated progenitors were the source of the tumors. (vetscite.org)
  • Blocking the expression of NF2 in the livers of adult mice had minimal effect on the animals unless a portion of the liver was surgically removed, setting off the regeneration process and leading to the same stem cell overproliferation and tumor development. (vetscite.org)
  • and suggests that liver tumors may originate from liver stem cells and that excess EGFR signaling leads to liver tumor development. (vetscite.org)
  • This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. (cancerindex.org)
  • Initial exponential tumor growth is followed by a plateau phase when cell death nearly equals the rate of formation of daughter cells. (msdmanuals.com)
Induces proliferation1
  • Small molecule that concentration dependently induces proliferation and enhances the functions of mature human primary hepatocytes. (axonmedchem.com)
Vivo5
  • Genetic in vivo lineage tracing revealed that the Krt15 promoter marks a long-lived basal cell population able to self-renew, proliferate, and generate differentiated cells, consistent with a progenitor/stem cell population. (jci.org)
  • Previous studies have proven that rodent and human MSCs can differentiate into HLCs in vitro and in vivo , which is one of the mechanisms of MSCs in the treatment of liver failure. (springer.com)
  • To enhance the osteogenic potential of stem cell sheet, we fabricated bone morphogenetic protein 2 ( BMP-2 ) gene-engineered cell sheet using a complex of polyethylenimine-alginate (PEI-al) nanocomposites plus human BMP-2 complementary(c)DNA plasmid, and studied its osteogenesis in vitro and in vivo. (dovepress.com)
  • To further test the osteogenic potential of the cell sheet in vivo, enhanced green fluorescent protein or BMP-2-producing cell sheets were treated on the cranial bone defects. (dovepress.com)
  • In vivo experiments were conducted using a co-implantation xenograft mouse model with live cell imaging and immunohistochemistry. (cdc.gov)
Hepatocytes3
Vitro2
  • These upregulated cytokines significantly facilitated stem cell motility, migration and proliferation in vitro. (sct4me.com)
  • Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)
Cirrhosis8
  • Hepatitis C virus (HCV) chronic infection induces liver fibrosis and cirrhosis but is also responsible for a significant portion of hepatocellular carcinoma (HCC) occurrence. (wjgnet.com)
  • Abnormal regeneration contributes to the pathogenesis of fulminate liver failure, cirrhosis, and primary liver cancers. (duke.edu)
  • Splenectomy, prior to cell infusion, improved liver function and suppressed fibrosis progression more efficiently than cell infusion alone in the experimental cirrhosis model. (sct4me.com)
  • [ 3 ] The HALT-C trial was a multicenter, randomized controlled study that evaluated whether long-term interferon would suppress HCV, prevent progression to cirrhosis, prevent liver cancer, and reduce the need for liver transplantation. (medscape.com)
  • The pathogenesis and clinical manifestations of hepatitis B are due to the interaction of the virus and the host immune system, which lead to liver injury and, potentially, cirrhosis and hepatocellular carcinoma. (medscape.com)
  • Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. (medscape.com)
  • Whereas in the past, HCC generally presented at an advanced stage with right-upper-quadrant pain, weight loss, and signs of decompensated liver disease, it is now increasingly recognized at a much earlier stage as a consequence of the routine screening of patients with known cirrhosis , using cross-sectional imaging studies and serum alpha-fetoprotein (AFP) measurements. (medscape.com)
  • There is also a growing problem with cirrhosis, which develops in the setting of nonalcoholic fatty liver disease (NAFLD), or nonalcoholic steatohepatitis (NASH). (medscape.com)
Suppresses1
  • Prolonged overexpression of TGF-β1 suppresses cell proliferation, is pro-apoptotic, and induces a deposition of ECM proteins, resulting in fibrosis in major organs such as the liver. (vin.com)
Hepatic regeneration2
Stem cell13
  • Stem cell therapy has developed extensively in recent years, leading to several new clinical fields. (ima.org.il)
  • This study investigated the effect of splenectomy on stem cell infusion and elucidated its mechanism. (sct4me.com)
  • Recently, stem cell- and gene-based therapy has been applied in BTE and achieved some good clinical results. (dovepress.com)
  • As ErbB-family ligands and receptors are highly expressed within the stem-cell niche 7 , we hypothesize that strong endogenous regulators must control the pathway in the stem-cell compartment. (nature.com)
  • Our findings reveal ErbB activation as a strong inductive signal for stem-cell proliferation. (nature.com)
  • HYPOTHESIS: Do LRIG Proteins Regulate Stem Cell Quiescence by Promoting BMP Signaling? (nature.com)
  • Figure 3: Loss of Lrig1 causes crypt and stem-cell expansion. (nature.com)
  • Morrison, S. J. & Spradling, A. C. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (nature.com)
  • Jensen, K. B. & Watt, F. M. Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. (nature.com)
  • RESULTS: We demonstrated that chemotherapy-stimulated CAFs promoted tumorigenic and stem cell-like properties of NSCLC cells, which contribute to their chemoresistance. (cdc.gov)
  • Silencing PDL-1 expression suppressed CAFs' ability to promote stem cell-like properties and invasiveness of lung cancer cells, favoring chemoresistance. (cdc.gov)
  • CONCLUSION: Our results show that PDL-1-positive CAFs modulate stem cell-like properties of NSCLC cells by secreting elevated HGF, thereby promoting chemoresistance. (cdc.gov)
  • and stem cell regeneration. (lu.se)
Assays4
  • The migration of these cells also increased as demonstrated by wound healing and transwell assays. (jcancer.org)
  • Assays on the cell culture showed that the genetically engineered cells released the BMP-2 for at least 14 days. (dovepress.com)
  • The current investigation aimed to demonstrate how interpretation of results from several standard cytotoxicity and proliferation assays vary in dependence on contributions from the pentose phosphate pathway (PPP). (cdc.gov)
  • Non-tumorigenic Beas-2B cells were treated with graded concentrations of benzo[a]pyrene (B[a]P) for 24 and 48h prior to cytotoxicity and proliferation assessment with commonly used MTT, MTS, WST1, and Alamar Blue assays. (cdc.gov)
Tissues5
  • Immunostaining against collagen I and III on normal liver tissues showed normal staining of the collagens in portal tracts, around the hepatic veins, as well as in the parasinoidal space (particularly centrolobular). (vin.com)
  • HMGCS2 , the gene that regulates ketone body production, is expressed in liver and several extrahepatic tissues, such as the colon. (aacrjournals.org)
  • Animal experimentation (Rat PH model) was performed to acquire liver tissues which were then used for western blot analysis to verify our results. (jomh.org)
  • Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
  • Cells Tissues Organs. (cancercentrum.se)
Migration5
  • The engineered bioderived components not only enhance adhesion but also promote cell proliferation and migration, enabling real-time in situ skin regeneration. (news-medical.net)
  • In contrast, silencing of UASR1 suppressed cell proliferation and migration. (jcancer.org)
  • C-X-C chemokine receptor type 4 neutralization weakened the promotion of cell migration by these cytokines. (sct4me.com)
  • Previously, we have shown that the tail regression step during metamorphosis, characterized by a predictable polarized apoptotic wave, ensures elimination of most tail cells and controls primordial germ cells survival and migration. (biomedcentral.com)
  • When caspase activity was impaired, genes known to be involved in metamorphosis were downregulated along with other implicated in cell migration and survival molecular pathways. (biomedcentral.com)
Fibrosis3
  • We analyzed liver fibrosis using several molecular and biochemical techniques (Q-PCR, Western blotting, and semi-quantitative immunohistochemistry on ECM proteins). (vin.com)
  • In CCl4-induced rodent models of liver fibrosis, TGF-β1 and procollagen mRNAs were increased, including procollagen I, III, and IV. (vin.com)
  • The infused cells integrated into liver fibrosis septa and participated in regeneration more efficiently in splenectomized rats. (sct4me.com)
Regulates4
  • It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. (joplink.net)
  • NF-κB signaling negatively regulates osteoblast dedifferentiation during zebrafish bone regeneration. (uni-ulm.de)
  • Overexpression up-regulates the Erk signaling pathway and proliferation. (joplink.net)
  • In this scholarly study, we also display that IP-LGF regulates the manifestation of protein that are crucial for cell success, and modulates the experience of both, the mitogen-activated proteins kinase/extracellular signal-regulated kinase (MAPK/ERK1/2) as well as the phosphatidylinositol 3-kinase (PI3K)/Akt sign transduction pathways. (antiviralbiologic.com)
Abstract2
  • ABSTRACT Several methods have been proposed to enhance the regeneration and healing time in periodontal therapy. (cn1699.cn)
  • Abstract Edible bird's nest (EBN) is a nutritious food with many beneficial effects, including protecting cells against ox. (cn1699.cn)
Progression4
  • The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. (wikipedia.org)
  • Numerous treatment strategies for acute liver failure simply prevent complications and decelerate disease progression. (springer.com)
  • Liver metastasis is a leading cause of death for CRC patients and, given the fact that CRC is among the top five cancers by incidence and mortality [ 4 ] , it is evident that this type of disease progression represents large cancer-related burden. (encyclopedia.pub)
  • Other common primary cancers that metastasize to the liver include lung, melanoma, breast, pancreatic, and gastric cancer, each with high incidences for this type of disease progression [ 3 ] . (encyclopedia.pub)
Pathway8
  • The Yap-Hippo pathway has a significant role in regulating cell proliferation and growth, thus controlling organ size and regeneration. (selectbiosciences.com)
  • Recently we reported on an siRNA screen, in a liver biliary cell line, to identify regulators of the Yap-Hippo pathway that allow activation of the YAP transcription co-activator at high cell density. (selectbiosciences.com)
  • Additionally, F-C3G demonstrated superior radicals scavenging than P-C3G, as well as to alleviate H2O2-induced damage in HepG2 cell via increasing superoxide dismutase by 43.26% and catalase by 39.83%, reducing malonaldehyde by 16.40% and cellular ROS production, and activating Nrf2 pathway. (bvsalud.org)
  • Further studies showed that UASR1 activated AKT and AKT-mediated mTOR signaling pathway to stimulate cell proliferation and growth. (jcancer.org)
  • Taken together, our data suggest that UASR1 plays an oncogenic role in breast cancer cells through activation of the AKT/mTOR signaling pathway, being a novel RNA oncogene. (jcancer.org)
  • Samarzija, I. Wnt Signaling Pathway in Liver Metastasis. (encyclopedia.pub)
  • Wnt Signaling Pathway in Liver Metastasis" Encyclopedia , https://encyclopedia.pub/entry/15642 (accessed November 30, 2023). (encyclopedia.pub)
  • Herein, the role of the Wnt signaling pathway in liver metastasis is outlined. (encyclopedia.pub)
Progenitor cells1
  • but if that growth is blocked or those cells are damaged, a population of less-differentiated progenitor cells will start to expand. (vetscite.org)
Metabolism2
  • A superior cell membrane therapeutic, PPC acts primarily on cellular repair, regeneration, proliferation and metabolism, with special emphasis on vulnerable organs such as the liver and brain. (nutrasal.com)
  • These results demonstrate differential sensitivity of standard cytotoxicity assessments on the PPP, thus (1) decoupling 'mitochondrial activity' as an interpretation of cellular formazan and Alamar Blue metabolism, and (2) demonstrating the implicit requirement for investigators to sufficiently verify interaction of these methods in routine cytotoxicity and proliferation characterization. (cdc.gov)
Involves4
  • The process involves seeding cells onto biocompatible scaffolds that temporarily act as a supporting structure for cells to attach and grow. (asme.org)
  • Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses. (uni-ulm.de)
  • We speculate that the mechanism underlying the ductal proliferation response involves differential expression of RXR [2] -alpha. (ima.org.il)
  • Traditional BTE involves three-dimensional biodegradable scaffolds, stem cells, and osteoinductive growth factors. (dovepress.com)
Adhesion1
  • MCP-1) and adhesion molecules (VCAM-1), in proliferating or differentiating C2C12 cells and primary myoblasts. (cdc.gov)
Growth8
  • Growth factors and cytokines involved in liver regeneration have also been shown to influence tumour growth and metastasis. (nih.gov)
  • May play a role in cell growth. (joplink.net)
  • Ectopic expression of UASR1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231. (jcancer.org)
  • The present study examines the involvement of vascular endothelial growth factor (VEGF) and angiopoietin-1 (ang-1) during liver regeneration. (biu.ac.il)
  • Liver growth element (LGF) is definitely a hepatic mitogen purified by Daz-Gil and colleagues some years ago [2]. (antiviralbiologic.com)
  • As human osteosarcoma cells are a source of additional growth they did not affect osteoinduction. (bvsalud.org)
  • Osteoblasts were obtained from human bone marrow cells even in the absence of growth factors and showed a typical morphology. (bvsalud.org)
  • Experiments suggest that the abilities to invade, migrate, and successfully implant and stimulate new blood vessel growth are all important properties of the cells that cause metastases, which are likely a subpopulation of the primary cancer. (msdmanuals.com)
Humans5
  • The liver is the most sensitive target in exposed humans and animals, independent of the route of administration, because of the abundance of CYP2E1 and other cytochromes. (cdc.gov)
  • Studies in animals, combined with limited observations in humans, indicate that the principal adverse health effects associated with inhalation exposure to carbon tetrachloride are central nervous system depression, liver damage, and kidney damage. (cdc.gov)
  • These mice go on to develop the two forms of liver cancer that are most common in humans, suggesting that liver stem cells may be the cells of origin of these tumors. (vetscite.org)
  • These liver stem cells have been identified in rodents, and potential equivalents found but not confirmed in humans. (vetscite.org)
  • Based on over 70 years of extensive clinical research (Humans and Animals), PPC plays a critical role in the healthy function of every cell and organelle (i.e. (nutrasal.com)
Cardiomyocyte1
Transplantation5
Organ2
  • These stem cells have renowned ability for use in cell therapy and organ regeneration. (asme.org)
  • Following an in-depth chemical and immunological study, they shown that LGF is an albuminCbilirubin complex, the focus which is normally undetectable in sera from healthful human beings or rats almost, but CHIR-99021 tyrosianse inhibitor significantly boosts in the current presence of hepatobiliary liver organ or disorders damage [3], [4]. (antiviralbiologic.com)
Intrahepatic2
  • Our observations suggest that deficiency of vitamin A may exacerbate cholestasis, due to excessive intrahepatic bile duct proliferation. (ima.org.il)
  • Another type of common liver cancer is intrahepatic cholangiocarcinoma (ICC). (encyclopedia.pub)
Bone9
  • The main interest of the use of bone marrow derived stem cells is their osteogenic potential for neoangiogenesis. (hindawi.com)
  • These different nanofiber scaffolds with nanoreservoirs are efficient proregenerative biomimicking implants for bone regeneration. (hindawi.com)
  • Regeneration of large bone defects is a common clinical problem. (dovepress.com)
  • The results indicated that the BMP-2-producing cell sheet group was more efficient than other groups in promoting bone formation in the defect area. (dovepress.com)
  • Regeneration of bone remains an important clinical challenge because the regeneration potential of human bone appears to be limited. (dovepress.com)
  • Objective: This study evaluated the osteogenic induction of human bone marrow cells by human recombinant bone morphogenetic protein-4 (rhBMP-4) and proteins released by Saos-2 (human osteosarcoma cell line). (bvsalud.org)
  • Study design: Osteoinduction in the presence or absence of Saos-2 and/or rhBMP-4 was evaluated in cultured human bone marrow cells. (bvsalud.org)
  • Results: Bone marrow cells were adherent since the first day of culture and were positive for osteonectin. (bvsalud.org)
  • Cancer cells, particularly those arising from the bone marrow or lymphatic system, may have a short generation time, and there usually are a smaller percentage of cells in G0 (resting phase). (msdmanuals.com)
Ability to regenerate1
  • Among adult organs, the liver is unique in its intrinsic ability to regenerate after injury through the proliferation of fully differentiated cells. (atlasofscience.org)
Injury6
  • Acute injury is caused by injury to the mitotically active intestinal crypt cells. (medscape.com)
  • Radiation injury impairs the normal repopulation of surface epithelium with growing new cells from the epithelial crypt cells. (medscape.com)
  • Further, Krt15 + cells were radioresistant and contributed to esophageal epithelial regeneration following radiation-induced injury. (jci.org)
  • Since liver progenitors need to be poised to regenerate in case of injury, they may be particularly sensitive to the loss of merlin's regulatory function. (vetscite.org)
  • Unlike other vital organs, the liver typically regenerates after injury. (duke.edu)
  • Proliferation of bile duct-like structures is a hepatic cellular reaction observed in most forms of human liver disease and in a variety of experimental conditions associated with liver injury. (idsemergencymanagement.com)
Nanofiber scaffolds2
  • The objective of this study is to quantify the effects of the addition of valproic acid to PCL nanofiber scaffolds created through the electrospinning process with regards to cell proliferation. (asme.org)
  • This study tests the hypothesis that the presence of valproic acid in PCL nanofiber scaffolds will enhance cell proliferation. (asme.org)
Mechanisms5
  • Zebrafish Fin: Complex Molecular Interactions and Cellular Mechanisms Guiding Regeneration. (uni-ulm.de)
  • We aimed to identify potential genes and reveal the underlying the molecular mechanisms involved in the precise regulation of liver size during the termination phase of LR. (jomh.org)
  • Liver regeneration-mechanisms and models to clinical application. (jomh.org)
  • The toxic effects associated with TCDD exposure include immunotoxicity and dysregulated cell cycle control, although the mechanisms are poorly understood. (boisestate.edu)
  • In this study, we investigated programmed death-ligand 1 (PDL-1) as a potential biomarker for CAF-induced chemoresistance and evaluated its role and the underlying mechanisms of chemoresistance in non-small cell lung cancer (NSCLC). (cdc.gov)
Inhibition1
Adult4
  • Wharton's jelly MSC are multipotent adult stem cells present in the umbilical cord and drawn from their matrix [1,2,3]. (asme.org)
  • Administration of dibutyryl-cyclic AMP to adult rats increases mRNA, protein levels, and enzymatic activity of HMGCS2 in the liver ( 6, 9 ). (aacrjournals.org)
  • In the August 15 issue of Genes & Development, a Massachusetts General Hospital (MGH) research team describes finding that the protein called merlin, encoded by the NF2 (neurofibromatosis type 2) gene, controls the activity of adult stem cells that give rise to the two major types of liver cells. (vetscite.org)
  • Li, L. & Clevers, H. Coexistence of quiescent and active adult stem cells in mammals. (nature.com)
Gene4
  • The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. (wikipedia.org)
  • Based on these findings, we propose that ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2 . (aacrjournals.org)
  • This presentation will review the nature of frequent hitters in biochemical and cell based assay and compare such compounds to gene targets that appear as frequent hitters in genetic screens. (selectbiosciences.com)
  • Explore our solutions for multiple applications - vaccines, monoclonal antibodies, recombinant proteins, cell or gene therapy. (vwr.com)
Markedly1
  • Pathways associated with cell cycle and proliferation were markedly upregulated in muscle-invasive and grade 3 cancers. (urotoday.com)
Diseases2
  • These results establish the presence of a long-lived and indispensable Krt15 + progenitor cell population that provides additional perspective on esophageal epithelial biology and the widely prevalent diseases that afflict this epithelium. (jci.org)
  • A better understanding of the extra- and intracellular signals that prompt the injured liver to regenerate should suggest treatments to promote liver regeneration in patients with otherwise fatal liver diseases. (duke.edu)
Cytokines1
  • This amelioration was characterized by an augmented ratio of Treg cells and M2 macrophages, a diminishment in pro-inflammatory cytokines (IL-1ß, TNF-α, IFN-γ, IL-23), and an elevation in the anti-inflammatory cytokine IL-10. (bvsalud.org)
Malignancy2
  • ICC is an aggressive epithelial malignancy of the bile ducts within the liver that is often locally advanced to metastatic disease and has an extremely poor prognosis. (encyclopedia.pub)
  • Another frequent cancer-related liver malignancy includes metastasis from the colorectal cancer (CRC) accounting for the most common primary cancer that metastasizes to the liver. (encyclopedia.pub)
Characterization1
  • However, potentially erroneous characterization of cytotoxicity and cell proliferation can arise if verification of baseline interaction of test article with method employed is neglected. (cdc.gov)
Metabolic2
  • Extensive research has shown that OC cells undergo significant metabolic alterations during tumorigenesis. (stanford.edu)
  • Optimizes liver cell metabolic functions. (nutrasal.com)
Bile4
Portal vein1
Physiology1
  • check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)
Mice1
  • To determine the relevance of NK cells to the TCDD-mediated suppression of liver regeneration, mice were treated with an α-asialo-GM-1 antibody to deplete NK cells prior to TCDD administration and PH. (boisestate.edu)
Rats1
  • In rats, hepatic ketogenic capacity increases rapidly during postnatal development ( 4 ) or fasting ( 5 ) when the mRNA, protein, and activity of HMGCS2 increase in liver ( 6 - 8 ). (aacrjournals.org)
Scaffolds1
  • Such studies will enable us to understand the effects of drugs such as valproic acid on stem cells and will aid in designing scaffolds for applications in nerve regeneration. (asme.org)
Stimulate1
Hypothesis1
  • However, contrary to our hypothesis, exposure to TCDD had no effect on the number of lymphocytes in the spleen or liver after PH, nor did it increase IFN-γ+ production by lymphocytes in the regenerating liver. (boisestate.edu)
Receptors1
  • TNFa delivers its signals to target cells by binding to specific cell surface membrane receptors (TNFR1 and TNFR2). (cdc.gov)
Metastasis3
  • Liver metastasis, originating either from a primary liver or other cancer types, represent a large cancer-related burden. (encyclopedia.pub)
  • Although metastasis originating from HCC and ICC can be detected in other organs, the most common site of metastasis of the primary HCC and ICC is the liver itself, which contributes to the above-mentioned recurrence scenarios. (encyclopedia.pub)
  • It is evident from these introductory lines that liver metastasis, originating either from primary liver or other cancer types ( Figure 1 ), represents a significant cancer-related complication. (encyclopedia.pub)
Pathways1
  • Liver regeneration (LR) is a complex process influenced by various genes and pathways, the majority of the of research on LR focus on the initiation and proliferation phase while studies on termination phase is lacking. (jomh.org)
Modulates1
Spleen4
  • Expressed at higher levels in liver, skin and spleen. (joplink.net)
  • Lymphocytes were collected from the spleen and remnant liver and analyzed by flow cytometry. (boisestate.edu)
  • [ 2 , 3 ] The software application uses quantitative analysis of nuclear medicine liver-spleen images to determine the severity of liver disease and to predict clinical outcomes. (medscape.com)
  • [ 3 ] The developer notes that Hepatiq "automates the Quantitative Liver Spleen Scan (QLSS) that has been proven to be an accurate predictor of clinical outcomes in the recently concluded HALT-C [ H epatitis C A ntiviral L ong-term T reatment against C irrhosis] trial. (medscape.com)
Genes1
  • While caspase-dependent signals emitted by apoptotic cells start to be characterised, almost no target genes are identified in receptor cells. (biomedcentral.com)
Immunohistochemistry1
Hepatocellular carcinoma1
  • The most common primary liver cancer is hepatocellular carcinoma (HCC), which is among the top cancers according to the incidence and mortality. (encyclopedia.pub)