Proliferating Cell Nuclear AntigenCell ProliferationCell SurvivalCell DivisionApoptosisSurvival RateSignal TransductionCells, CulturedCell Line, TumorCell CycleCell DifferentiationCell LineDisease-Free SurvivalPhosphorylationImmunohistochemistryTime FactorsBlotting, WesternRNA, MessengerMice, Inbred C57BLBromodeoxyuridineRNA, Small InterferingCell MovementGene Expression Regulation, NeoplasticReverse Transcriptase Polymerase Chain ReactionSurvivalTumor Cells, CulturedProto-Oncogene Proteins c-aktMice, KnockoutSurvival AnalysisTransfectionDown-RegulationGraft SurvivalGene Expression RegulationDose-Response Relationship, DrugProto-Oncogene ProteinsMice, TransgenicProtein-Serine-Threonine KinasesAntineoplastic AgentsKi-67 AntigenUp-RegulationEnzyme ActivationLymphocyte ActivationRNA InterferenceCell Growth ProcessesPhosphatidylinositol 3-KinasesEpithelial CellsGene ExpressionMice, NudeCell DeathFlow CytometryTranscription FactorsStem CellsBreast NeoplasmsFibroblastsT-LymphocytesEnzyme InhibitorsMice, Inbred BALB CCell CountMutationMolecular Sequence DataDNA-Binding ProteinsGene Knockdown TechniquesModels, BiologicalCyclin D1Tumor Suppressor Protein p53Cell Transformation, NeoplasticDisease Models, AnimalNeoplasmsExtracellular Signal-Regulated MAP KinasesCell Cycle ProteinsMAP Kinase Signaling SystemIn Situ Nick-End LabelingRats, Sprague-DawleyThymidineMitogen-Activated Protein KinasesProto-Oncogene Proteins c-bcl-2DNABase SequenceTreatment OutcomeCyclin-Dependent Kinase Inhibitor p27Nuclear ProteinsPhenotypeGene Expression ProfilingTumor Suppressor ProteinsLung NeoplasmsGene Expression Regulation, DevelopmentalNeoplasm ProteinsCaspase 3Cell AdhesionMitogen-Activated Protein Kinase 3Muscle, Smooth, VascularRecombinant ProteinsNeoplasm InvasivenessProto-Oncogene Proteins c-mycProtein BindingNF-kappa BCyclin-Dependent Kinase Inhibitor p21Mitogen-Activated Protein Kinase 1Membrane ProteinsNeovascularization, Pathologic