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  • Mechanisms
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of the molecular mechanisms involved in establishing and maintaining cell polarity, as well as their relevance for human disorders. (cshlpress.com)
  • Attempts to elucidate the mechanisms by which these two distinct cell types diverge from a common pathway during the first 3 days of preimplantation development have yielded not only clues as to possible differentiative signals operating in development, but also detailed structural information on the morphology and properties of cells from the early embryo. (springer.com)
  • This is achieved by two mechanisms: cell proliferation and recruitment of additional cells. (hindawi.com)
  • however, the mechanisms that control this cell behavior are poorly understood. (sciencemag.org)
  • The aims of this meeting are to bring together as diverse a group as possible of experimental and theoretical biologists who are interested in mechanisms of coordinated cell polarisation in plants and animals. (biologists.com)
  • morphogenesis
  • In recent years, great progress has been made by experimental biologists towards understanding how during plant and animal morphogenesis cells become polarised in a manner that is coordinated between each other and the axes of the tissue. (biologists.com)
  • The asymmetrically dividing bacterium Caulobacter crescentus uses one such microdomain to link cell cycle progression to morphogenesis, but the mechanism for the generation of this microdomain has remained unclear. (asm.org)
  • Complexes
  • Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). (uniprot.org)
  • Our poster showcases repeated use of the Par, Scribble and Crumbs polarity complexes, which drive the development of cell polarity in many cell types and organisms. (biologists.org)
  • In this Cell Science at a glance review and the accompanying poster, we highlight how these complexes pattern early development of diverse animal embryos, and drive asymmetries in cell shape and division. (biologists.org)
  • disruption
  • Using a 3-D co-culture model of breast cancer cells and monocytes, Markey's Ren Xu and Linzhang Li found that disruption of cell polarity is accompanied by increased ROS production, leading to increased inflammation in these cells. (uky.edu)
  • consequently
  • Decisions about the subcellular polar targeting of PIN auxin transport components determine the direction of auxin flow between cells and consequently mediate multiple developmental events. (ugent.be)
  • coordinates
  • Together, PopZ and SpmX assemble into a cooligomeric network that forms the basis for a polar microdomain that coordinates bacterial cell polarity. (asm.org)
  • Development
  • these cell asymmetries may play important roles in embryonic development. (springer.com)
  • Overall, the present concluded that Wnt4 has an important role in thymoma development, which appears to be activated through a JNK mediated planar cell polarity‑like pathway. (spandidos-publications.com)
  • Loss of cell polarity and inflammation are hallmarks of breast cancer development. (uky.edu)
  • In plants, cell polarity is an issue more recurring than in other systems, because plants, due to their adaptive and flexible development, often change cell polarity postembryonically according to intrinsic cues and demands of the environment. (ugent.be)
  • fate
  • Here, we recapitulate the tripartite assembly of a cell fate signaling complex that forms during the G 1 -S transition. (asm.org)
  • lateral
  • Later, these cells migrate from the streak in an anterior-lateral direction to positions under the headfolds forming two groups of cells on either side of the midline [ 9 ]. (hindawi.com)
  • Hierarchical formation of higher-order SpmX oligomers nucleates new PopZ microdomain assemblies at the incipient lateral cell poles, driving localized outgrowth. (asm.org)
  • cilia
  • Planar cell polarity signaling, cilia and polarized ciliary beating. (nih.gov)
  • Interestingly, PCP signaling acts in a variety of ciliated cell types that use motile cilia to generate directional fluid flow in very different ways. (nih.gov)
  • extend
  • The cells then extend across the midline to develop a crescent-shaped epithelium called the cardiac crescent, which fuses at the midline to form the early heart tube [ 7 ] called the primary heart field or the first heart field (FHF). (hindawi.com)
  • In contrast, migrating cells extend highly dynamic lamellipodia and filopodia primarily from leading edges to drive forward protrusion, while the rear retracts resulting in net movement. (biologists.org)
  • Here we review the available literature on the issues of cell polarity in both plants and animals to extend our understanding on the generation, maintenance, and transmission of cell polarity in plants. (ugent.be)