This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. (genemedi.net)
Dihydropyridines1
They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). (hmdb.ca)
Calcium3
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. (hmdb.ca)
The type III mGluR agonist l -2-amino-4-phosphonobutyrate consistently inhibited 5HT-evoked calcium rises, whereas in a smaller number of cells quisqualate and L-CCG-I showed both inhibitory and additive effects. (jneurosci.org)
The selectivity of Huwentoxin-I for calcium channels appears to be higher than ω-conotoxin MVIIA and equivalent to ω-conotoxin GVIA . (smartox-biotech.com)
Hippocampus2
The hippocampus stains for γ 2 and γ 4 throughout the layers of the every CA region and the dentate gyrus, whilst γ 3 appears to be localized particularly to the pyramidal and granule cell bodies. (biomedcentral.com)
The human γ 2 , γ 3 and γ 4 stargazin-like proteins are detected only in the CNS and display differential distributions among brain regions and several cell types in found in the cerebellum and hippocampus. (biomedcentral.com)
Vivo1
Whilst the fact that neither γ 2 nor γ 4 modulated the properties of a VDCC complex with which they could associate in vivo in Purkinje cells adds weight to the hypothesis that the principal role of these proteins is not as auxiliary subunits of VDCCs, it does not exclude the possibility that they play another role in VDCC function. (biomedcentral.com)
Lung1
Adoptive transfer of lymphocytes treated with S1P(1R) siRNA to rat Wistar Kyoto (WKY) lung isograft recipients resulted in retention of cells within the liver with fewer cells in mediastinal lymph nodes when compared to cells exposed to SC siRNA. (bvsalud.org)
Biological1
The anti-CACNA1B mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. (genemedi.net)
Expression1
Immunohistochemical analysis of the cerebellum determined that both γ 2 and γ 4 are present in the molecular layer, particularly in Purkinje cell bodies and dendrites, but have an inverse expression pattern to one another in the dentate cerebellar nucleus. (biomedcentral.com)
Lines1
Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)
Inhibition7
At concentrations around 100-fold higher than that needed for inhibition of chemotaxis, each of these antagonists inhibited motility (measured as entry of cells into a capillary lacking attractant). (nih.gov)
1. Voltage-dependent inhibition of Ca2+ channels in GH3 cells by cloned mu- and delta-opioid receptors. (nih.gov)
15. Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons. (nih.gov)
A class of drugs that act by inhibition of potassium efflux through cell membranes. (lookformedical.com)
Glutamate released from mitral cell dendrites excites the dendrites of granule cells, which in turn mediate GABAergic dendrodendritic inhibition back onto mitral dendrites. (nih.gov)
Furthermore, recordings from pairs of mitral cells show that dendrodendritic synapses can mediate lateral inhibition independently of axonal action potentials. (nih.gov)
However, tetrodotoxin (3 microM), nimodipine (10 microM), omega-GVIA conotoxin (1 microM), thapsigargin (1 microM), U73122 (3 microM) or H-89 (3 microM) had no effect on the capsaicin (100 nM)-induced response. (ox.ac.uk)
Sinoatrial node1
They are found in cardiac myocyte membranes, the sinoatrial node, Purkinje cells of the heart and the central nervous system. (lookformedical.com)
Neurons1
In neurons, calcium channel inhibitors can decrease the excitability of cells by reducing calcium influx, which can be beneficial in certain neurological conditions characterized by hyperexcitability. (alomone.com)
Receptors5
2. Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells. (nih.gov)
3. Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory. (nih.gov)
4. Cloned delta-opioid receptors in GH(3) cells inhibit spontaneous Ca(2+) oscillations and prolactin release through K(IR) channel activation. (nih.gov)
6. delta-Opioid receptors are more efficiently coupled to adenylyl cyclase than to L-type Ca(2+) channels in transfected rat pituitary cells. (nih.gov)
13. Constitutively active mu-opioid receptors inhibit adenylyl cyclase activity in intact cells and activate G-proteins differently than the agonist [D-Ala2,N-MePhe4,Gly-ol5]enkephalin. (nih.gov)
Inhibit3
5. Mu and delta opioids but not kappa opioid inhibit voltage-activated Ba2+ currents in neuronal F-11 cell. (nih.gov)
Omega toxins inhibit the actions of these channels by altering their voltage dependence. (lookformedical.com)
Calcium channel inhibitors block or inhibit the activity of calcium channels, reducing the influx of calcium ions into cells. (alomone.com)
Blockers1
Various Ca(2+) antagonists used in animal research, many of them known to be Ca(2+) channel blockers, inhibited Escherichia coli chemotaxis (measured as entry of cells into a capillary containing attractant). (nih.gov)
Calcium influx1
Voltage-gated calcium channels (VGCCs) enable calcium influx during cell membrane depolarization and are essential for a range of physiological functions such as neurotransmission, muscular contraction, membrane excitability, synaptic plasticity, and gene expression. (alomone.com)
Neural1
9. Go mediates the coupling of the mu opioid receptor to adenylyl cyclase in cloned neural cells and brain. (nih.gov)
Membrane2
Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. (lookformedical.com)
Cell membrane glycoproteins that form channels to selectively pass chloride ions. (lookformedical.com)
Recombinant2
7. The effects of recombinant rat mu-opioid receptor activation in CHO cells on phospholipase C, [Ca2+]i and adenylyl cyclase. (nih.gov)
In conclusion, the recombinant rVR1 stably expressed in HEK293 cells acts as a ligand-gated Ca(2+) channel with the appropriate agonist and antagonist pharmacology, and therefore is a suitable model for studying the effects of drugs at this receptor. (ox.ac.uk)
Intracellular2
10. delta- and mu-opioid receptor mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells. (nih.gov)
Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. (lookformedical.com)
Histologic study of the actual curetted lesion revealed a nicely circumscribed spindle cell neoplasm presenting predominantly storiform yet focally whorled patterns. (pdgfrsignaling.com)
VGCC antibodies can be used to determine the localization and expression patterns of specific VGCC subtypes in different tissues and cell types. (alomone.com)
Channels4
Potassium channels where the flow of K+ ions into the cell is greater than the outward flow. (lookformedical.com)
CALCIUM CHANNELS located within the PURKINJE CELLS of the cerebellum. (lookformedical.com)
By inhibiting calcium channels in smooth muscle cells of blood vessels, calcium channel inhibitors can promote vasodilation, leading to decreased vascular resistance and blood pressure. (alomone.com)
Calcium channel activators enhance or activate the opening of calcium channels, increasing the influx of calcium ions into cells. (alomone.com)