Cell nucleus regulation cell cycle. Medical search. Frequent questions

In the present study, we analyze the activity and binding of Sp3 on several eukaryotic promoters that contain G/C boxes and are known to be regulated during cellular proliferation and the cell cycle. (nih.gov)
The data suggest that Sp3 may contribute to the control of proliferation- and/or cell-regulated promoters depending upon the context and/or number of functional Sp1 binding sites. (nih.gov)
Taken together, our study establishes crucial roles for the AtASF1A and AtASF1B genes in chromatin replication, maintenance of genome integrity and cell proliferation during plant development. (nih.gov)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. (microarraystation.com)
Immunohistochemical analysis of paired tumor biopsies revealed increased nuclear accumulation of tumor suppressor proteins (TSPs), decreased cell proliferation, and increased tumor cell apoptosis after treatment. (karyopharm.com)
Taken together, our results suggested that decreased LAPTM5 inhibited proliferation and viability, as well as induced G0/G1 cell cycle arrest possibly via deactivation of ERK1/2 and p38 in BCa cells. (spandidos-publications.com)
Furthermore, previous studies suggested that knockdown of LAPTM4B , another important subtype of the LAPTM family inhibited proliferation of hepatocellular carcinoma ( 11 ), prostate ( 12 ) and breast cancer cells ( 13 ). (spandidos-publications.com)
Failure of mammalian cells to regulate their proliferation cycle leads to cancer. (nih.gov)
2009). Evidence of similarities in the redox control of cell proliferation in animals and plants are provided, particularly glutathione recruitment into the nucleus early in the cell proliferation, which appears to be important in the control of progression through the cell cycle in both kingdoms. (cam.ac.uk)
MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. (thermofisher.com)
Although senescent cells repress proliferation-promoting genes, they also induce the gene program necessary for the implementation of senescence. (rupress.org)
The Ets family of transcription factors includes nuclear phosphoproteins that are involved in cell proliferation, differentiation and oncogenic transformation. (embl.de)

Here we report that both AtASF1A and AtASF1B proteins bind histone H3, and are localized in the cytoplasm and the nucleus. (nih.gov)
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)

It is located on the cell membrane of ghrelin cells in the stomach and pancreas. (wikipedia.org)
During endocytosis, extracellular molecules and plasma membrane components are selectively internalized by cells. (cshlpress.com)
Pulsating tandem microbubble for localized and directional single-cell membrane poration. (duke.edu)
Prokaryotes (bacteria) do NOT have a nucleus or membrane bound organelles. (proprofs.com)
It may play a role in cell membrane rearrangement. (microarraystation.com)
Together with LINC, CII plays a role in scattering centromeres around the nuclear periphery during late anaphase, when the cell membrane invaginates, and telophase, when daughter cells physically separate during the terminal stages of cell division. (genengnews.com)
Intracellular signaling pathways leading from cell membrane receptors to nucleus. (mcb-seattle.edu)
Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. (spandidos-publications.com)
LAPMT5 is a lysosomal membrane protein preferentially expressed in immune cells ( 5 , 6 ) and hematopoietic cells ( 7 ), having a close interaction with the Nedd4 ( 8 ), a member of the E3 ubiquitin ligases family ( 8 ). (spandidos-publications.com)
Cy5 is labeled as magenta, and the cell membrane is stained with rabbit anti-human epidermal growth factor receptor and goat anti rabbit488 antibody. (medicalxpress.com)
A growing body of evidence suggests that cell division and basement membrane invasion are mutually exclusive cellular behaviors. (elifesciences.org)
A growing body of evidence suggests that cell cycle progression and invasion through a basement membrane are mutually exclusive cellular behaviors in both development and disease states (reviewed in Kohrman and Matus, 2017 ). (elifesciences.org)

This fundamental process of cellular ingestion is required for diverse activities such as nutrient uptake, cell adhesion and migration, signal transduction, cytokinesis, neurotransmission, and antigen presentation. (cshlpress.com)
Biological Function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. (qedbio.com)
Nerve cells: signal transduction (action potential), neurotransmitters and receptors. (pmf.hr)
16. To explain molecular mechanisms involved in signal transduction in nerve cells. (pmf.hr)

Ghrelin and synthetic ghrelin mimetics (growth hormone secretagogues) increase body weight and fat mass by triggering receptors in the arcuate nucleus that include neuropeptide Y (NPY) and agouti-related protein (AgRP) neurons. (wikipedia.org)
Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. (novusbio.com)
Most of the Hsp90-regulated proteins are involved in cell signaling and include the kinases, v-Src, Wee1, c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of hepatitis B virus and telomerase. (qedbio.com)
Such continuous sensing of signal intensity might involve cycling of receptors through the endocytic pathway. (nature.com)
cell signaling: hormones and their receptors, growth factors. (pmf.hr)
Extinction-induced upregula- the work of Sutton et al .3, it has consid- of calcium into nucleus accumbens neu- tion in AMPA receptors reduces cocaine-seeking behaviour. (lu.se)

By blocking cell cycle progression, p27 prevents cells from dividing too quickly or at the wrong time. (medlineplus.gov)

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus, and that occurs as a response to the mitotic cell cycle spindle assembly checkpoint. (yeastgenome.org)
Still other mutations prevent p27 from moving from the cytoplasm into the nucleus. (medlineplus.gov)

The overexpression of XPO1 is one mechanism by which neoplastic cells inactivate TSPs and thereby circumvent cell-cycle regulation, genome survey and apoptosis. (karyopharm.com)
Selinexor inhibits XPO1, resulting in the accumulation of TSPs and other key mediators in the nucleus, restoring cell-cycle checkpoints and inducing growth arrest and apoptosis in malignant cells. (karyopharm.com)
ADAR1 silencing in breast cancer cells leads to increased apoptosis, suggesting an anti-apoptotic function that promotes cancer progression. (cancerindex.org)
In contrast, no significant alteration of apoptosis in the BCa cells with downregulated LAPTM5 was noticed. (spandidos-publications.com)
After entering into various tissues including lungs it up-regulates and down-regulates some critical host genes that are related to cell cycle regulation and apoptosis. (medicinepaper.net)
Cell death and stem cells: apoptosis, necrosis, embryonic stem cells, bone marrow stem cells. (pmf.hr)
14. To describe mayor signs of controlled cell death (apoptosis). (pmf.hr)

Activation of the Cyclin B/Cdc2 kinase complex triggers entry into mitosis in all eukaryotic cells. (duke.edu)
Chromosomal centromeres attached to microtubules and pulled to opposite poles of the cell during mitosis are retained in the chromatin structure even when the cell is done dividing. (genengnews.com)
The Seattle Mitosis Group is a collective of six labs interested in exploring fundamental questions about mitosis, including its structure, regulation and mechanics. (mcb-seattle.edu)
When cells pass from S to G 2 , the nuclei migrate toward the VZ surface where mitosis occurs. (jneurosci.org)
After mitosis, daughter cells can either remain proliferative and re-enter the cell cycle or become terminally postmitotic and migrate out of the VZ ( McConnell, 1995 ). (jneurosci.org)
Many chemotherapeutic agents explore defects in the cell cycle machinery of cancer cells to halt the cycle through mitosis inhibition. (medicalxpress.com)
However, existing mitosis-targeting chemotherapeutic agents do not discriminate between healthy and malignant cell lines, resulting in severe side-effects . (medicalxpress.com)
The challenge therefore is to identify molecular targets associated with mitosis of cancer cells. (medicalxpress.com)
Cell mitosis is an attractive target to effectively treat a variety of cancer forms, where microtubule-associated proteins (MAPs) assist cells to maintain the stability of cell dynamics. (medicalxpress.com)
Regulation of the cell cycle: mitosis, meiosis. (pmf.hr)

In the Rabl configuration, the free ends of the chromatids-another region of condensed chromatin called telomeres-are clustered at the opposite end of the nucleus, with respect to the centromeres. (genengnews.com)
We feature research from the structure and function of chromatin to the dynamics of chromosome movement during cell division. (mcb-seattle.edu)
An increase in the threshold cycle (C T ) of a target sequence PCR product from activated cells was indicative of stimulation-induced chromatin remodelling. (biomedcentral.com)
However, altered regulation of NF-κB expression and activity in TNF-treated cells may contribute to poor inducibility of IL-2 through effects on stimulus-induced changes in chromatin conformation across pIL-2. (biomedcentral.com)

Acts upstream of or within cellular response to DNA damage stimulus and positive regulation of G1/S transition of mitotic cell cycle. (nih.gov)

The mechanisms used by certain viruses to dysregulate the host cell through manipulation of epigenetic processes and the role of cellular cofactors such as BRD4 that are known to be involved in epigenetic regulation of host cell pathways will also be covered. (mdpi.com)
HIV) exploit endocytic pathways to gain entry into cells, and defects in the endocytic machinery can lead to diseases such as cancer. (cshlpress.com)
Contributors describe how cargo enters the cell via clathrin-mediated and clathrin-independent pathways, including caveolar endocytosis, micropinocytosis, cholesterol-sensitive endocytosis, phagocytosis, and the CLIC/GEEC pathway. (cshlpress.com)
It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
We discuss the rationale of various anti-fibrogenic treatment strategies targeting the clonal hematopoietic stem/progenitor cell, aberrant signaling pathways, fibrogenic cytokines, and the tumor microenvironment. (haematologica.org)
The molecular underpinnings common to and connecting these disorders are not known, but may include shared genetic risk factors ( 1 , 8 ), regulation of brain cations ( 9 , 10 ), or common receptor signaling events that activate pain ( 11 ), inflammation ( 12 ), or oxidative ( 13 ) pathways. (frontiersin.org)
RNA-seq results indicated that GmKRP2a is involved in cell cycle regulation through ribosome regulation, cell expansion, hormone response, stress response, and plant pathogen response pathways. (bvsalud.org)
We have found that, although chronic TNF attenuates TCRζ expression and TCR-proximal signalling, IL-2 expression is suppressed regardless of whether cells are stimulated via the TCR, or with phorbol ester and calcium ionophore to activate the MAPK and NFAT pathways directly. (biomedcentral.com)

Ghrelin also participates in regulation of reward cognition, learning and memory, the sleep-wake cycle, taste sensation, reward behavior, and glucose metabolism. (wikipedia.org)
Genetics of CoV reveals that many nonstructural protein and structural proteins impacts host cell protein metabolism and gene expression. (medicinepaper.net)
GSH recruitment into the nucleus has marked effects on metabolism and signaling in the cytoplasm, chloroplasts and nucleus. (cam.ac.uk)

The transcription factor Sp1 plays a key role in the activation of many cellular and viral gene promoters, including those that are regulated during the cell cycle. (nih.gov)
It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. (mdpi.com)
It is thus an indispensable reference for cell biologists, but also for neuroscientists, immunologists, developmental biologists, microbiologists, and others concerned with the physiological and therapeutic implications of this key cellular process. (cshlpress.com)
They have important roles in the regulation of cellular functions both in the adult organism and during embryogenesis. (nature.com)
Cellular morphology, time-lapse imaging, and nuclear staining demonstrated that this activity occurred in mitotically active cells. (jneurosci.org)
E2 is expressed throughout the differentiation-dependent virus life cycle and is functionally regulated by association with multiple viral and cellular proteins. (microbiologyresearch.org)
We propose a model in which association of NHR-67 with the Groucho/TCF complex suppresses the default invasive state in non-invasive cells, which complements transcriptional regulation to add robustness to the proliferative-invasive cellular switch in vivo . (elifesciences.org)
During development of the hermaphroditic reproductive system, the proximal granddaughters of the Z1 and Z4 somatic gonad progenitors, Z1.pp and Z4.aa, give rise to four cells that will adopt one of two cellular fates: a proliferative ventral uterine (VU) cell or the terminally differentiated, invasive anchor cell (AC) ( Figure 1A ) ( Kimble and Hirsh, 1979 ). (elifesciences.org)
Cellular redox homeostasis is considered to play an important role in the regulation of the plant cell cycle but there is little information on the precise functions of key redox metabolites such as ascorbate, glutathione and pyridine nucleotides in this process. (cam.ac.uk)
Cellular senescence was first identified as a type of irreversible cell cycle arrest that occurs when cells reach the end of their replicative potential ( Hayflick and Moorhead, 1961 ). (rupress.org)
Senescent cells also undergo dramatic changes in their morphology and in the organization and architecture of their cellular compartments. (rupress.org)
Another characteristic architectural feature found in many of these tumors is a pseudoalveolar pattern in which cells are arranged in alveolae with central cellular discohesion (see the fourth image below). (medscape.com)

Loss of both CDK4 and CDK2 increases neural stem cell differentiation. (rndsystems.com)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
Studies suggest that p27 is also involved in controlling cell differentiation, which is the process by which cells mature to carry out specific functions. (medlineplus.gov)

Seattle MCB faculty take various approaches to investigate how cells maintain proper cell cycle progression, chromosomal organization, DNA replication, transcription, DNA repair and chromosome segregation. (mcb-seattle.edu)
Thus, SMADs both transmit the signal into the nucleus and execute the downstream effects by directly regulating target-gene transcription. (nature.com)
Using cell-based assays, we show that co-expression of L1 and E2 results in enhanced transcription and virus origin-dependent DNA replication. (microbiologyresearch.org)
7. To define how signals are transmitted into the nucleus and how gene transcription is activated. (pmf.hr)
Transcription of nhr-67 is downregulated following post-translational degradation of its direct upstream regulator, HLH-2 (E/Daughterless) in VU cells. (elifesciences.org)
This valuable data study presents convincing data that expression of the C. elegans transcription factor NHR-67 is sufficient to drive an invasive fate, and that the alternative proliferative fate is associated with NHR-67 transcriptional down-regulation. (elifesciences.org)
Translocation carcinoma is a renal cell carcinoma (RCC) subtype that harbors a translocation involving a member of the microphthalmia transcription factor gene family. (medscape.com)

It helps regulate the cell cycle, which is the cell's way of replicating itself in an organized, step-by-step fashion. (medlineplus.gov)
All of these mutations reduce the amount of functional p27 that is available in the nucleus to regulate the cell cycle. (medlineplus.gov)
Current research is focused on the mechanisms that regulate SMAD activity to evoke cell-type-specific and context-dependent transcriptional programmes. (nature.com)
One such protein is the cytoskeleton-associated protein 5 (CKAP5), widely expressed in a variety of cells to regulate the dynamics of microtubules in human cells. (medicalxpress.com)

Using the plant Arabidopsis thaliana , also known as thale cress, as their model for non-Rabl configuration, and its mutant form with a Rabl configuration, the scientists found the protein complexes CII (condensin II) and LINC (linker of nucleoskeleton and cytoskeleton) work together to determine centromere distribution during cell division. (genengnews.com)

For example, when p27 is held (sequestered) in the fluid that surrounds the nucleus (the cytoplasm) instead of being transported into the nucleus, the protein is unavailable to block cell cycle progression. (medlineplus.gov)
Second, it appears to block cell cycle progression, possibly via a down-regulation of CDK proteins. (rndsystems.com)

Avoid freeze-thaw cycles. (novusbio.com)

1 Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655, USA. (nih.gov)
In our studies, we employ a range of genetic, biochemical, cell biology, computational and genomic methods using predominantly the fission yeast Schizosaccharomyces pombe as a model. (google.com)
We are part of the Department of Cell Biology , Faculty of Science, Charles University. (google.com)
They also provide a listing of suggested courses for those interested in Gene Expression, Cell Cycle & Chromosome Biology. (mcb-seattle.edu)
introductory biochemistry and cell biology. (mcb-seattle.edu)
My laboratory has developed new technologies and applied them towards understanding the molecular biology and enzymology of DNA replication in animal cells and viruses (SV40, polyomavirus, papillomavirus, and herpes simplex virus), and at the beginning of animal development (mouse preimplantation embryos and frog eggs). (nih.gov)
The biology and life-cycle of human papillomaviruses. (microbiologyresearch.org)
We already have many examples ure of a discrete action (lever press) to in the sensitivity of nucleus accumbens of how brain biology can affect behav- produce the expected results (cocaine). (lu.se)

The Laboratory of Microbial Genomics studies how gene expression is regulated during the cell cycle and in response to various stimuli, such as nutrients or stress. (google.com)
Selective up-regulation of expression of a subset of genes, including those involved in S-phase checkpoints and the CYCB1;1 gene at the G₂-to-M transition, was observed in Atasf1ab. (nih.gov)
Alternatively, similar course material is covered in GENOME 551 - Principles of Gene Regulation (Winter, weeks 6-10, will be offered in Winter 2024, 1.5 credits). (mcb-seattle.edu)
The researchers screened 20 solid cancer cell lines relative to gene silencing to identify a highly responsive chemo-resistant ovarian cancer cell line that underwent significant depletion in mitotic spindle-dynamics for effective experimental cancer treatment. (medicalxpress.com)
How does tumour necrosis factor uncouple T-cell receptor-induced IL-2 gene expression in murine T cells? (biomedcentral.com)

Cells were grown in the presence or absence of 2.5 ng/ml murine TNF for 8 days. (biomedcentral.com)
Chronic culture of murine T cells in TNF does not alter the stability of IL-2 mRNA induced via TCR, or by PMA and ionomycin, in those cells. (biomedcentral.com)

Transient cotransfections of Drosophila cells with Sp1 and Sp3 expression vectors and with the histone H4, thymidine kinase (TK), or dihydrofolate reductase (DHFR) promoters show that only the DHFR promoter, containing multiple functional GC boxes, displays Sp3 repression of Sp1 activation. (nih.gov)
CDK4 may be useful as a prognostic marker for hepatocellular carcinoma and its kinase activity has been reported to promote the progression of T cell acute lymphoblastic leukemia. (rndsystems.com)
Consequently, most cyclin-dependent kinase (Cdk)/cyclin complexes are localized to the nucleus when active. (duke.edu)
The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)
Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. (thermofisher.com)
The defining characteristic of senescence is a highly stable cell cycle arrest, triggered by the up-regulation of cyclin-dependent kinase inhibitors such as p16 INK4a and p21 CIP1a . (rupress.org)

Since their discovery, scientists have noted that the arrangement of centromeres in the nucleus between cell divisions differs among species, cell-types, cell-cycle stage, and the cell's state of specialization, but neither the underlying mechanism of their seemingly random nuclear distribution nor its biological significance was clear, until now. (genengnews.com)
The centromere distribution for non-Rabl configuration is regulated independently by the CII- LINC complex and a nuclear lamina protein known as CRWN (crowded nuclei)," Matsunaga said. (genengnews.com)
Once the cell has divided and entered interphase, CRWN proteins stabilize the positions of the scattered centromeres on the inner surface of the nuclear envelop, in the second step. (genengnews.com)
During this time, precursor cells undergo interkinetic nuclear migration ( Seymour and Berry, 1975 ) in which cells in the DNA synthetic S phase have their nuclei in the upper third of the VZ. (jneurosci.org)
2009) Pyridine nucleotide cycling and control of intracellular redox state in relation to poly (ADP-ribose) polymerase activity and nuclear localisation of glutathione during exponential growth of Arabidopsis cells in culture. (cam.ac.uk)
In Xp11.2 translocation-associated renal cell carcinoma, tumor cells with abundant eosinophilic cytoplasm and high nuclear grade are often arranged in large nests with a delicate, intervening vascular stroma. (medscape.com)

This induces dimerization with ARNT, translocation to the nucleus, and activation of P450 genes such as CYP1A1 and UGT1A6. (rndsystems.com)
In fact, amplification of genes by over replication of certain regions of DNA is one of the primary mechanisms by which cancer cells become resistant to drug therapy. (nih.gov)
While the observation that NHR-67 forms punctae associated with transcriptional repressors in non-invasive cells is intriguing, the work does not yet established a clear link between the formation and dissolution of NHR-67 condensates with the activation of downstream genes that NHR-67 is actively repressing. (elifesciences.org)
Genes necessary for cell cycle progression, such as E2F-dependent genes, are incorporated into the SAHF and are thereby silenced, contributing to the stability of the growth arrest. (rupress.org)

It is also highly expressed in unstressed cells where it participates in controlling the activity, turnover, and trafficking of a variety of proteins. (qedbio.com)
GmKRP2a is located in the nucleus and participates in root development by regulating cell cycle progression. (bvsalud.org)

Ghrelin activates cells in the anterior pituitary gland and hypothalamic arcuate nucleus, including neuropeptide Y neurons that initiate appetite. (wikipedia.org)
In contrast to previous studies, modafinil did not produce statistically significant increases in Fos expression in either the suprachiasmatic nucleus or the anterior hypothalamic area. (jneurosci.org)

Translocation-associated renal cell carcinomas (RCCs) arise from the proximal tubule epithelium, similar to conventional clear cell and papillary RCCs. (medscape.com)
Xp11.2 translocation-associated renal cell carcinomas are generally cortical or subcapsular, well-circumscribed lesions with yellow-tan, variegated cut surfaces. (medscape.com)
In Xp11.2 translocation-associated renal cell carcinoma (RCC), cells typically have voluminous cytoplasm, which can range from eosinophilic and granular to clear. (medscape.com)
Xp11.2 translocation-associated renal cell carcinomas (RCCs) may have well-developed papillae, mimicking papillary RCCs. (medscape.com)
The nests of tumor cells in Xp11.2 translocation-associated renal cell carcinomas may become centrally discohesive, giving rise to a pseudoalveolar growth pattern. (medscape.com)

Western Blot: LMP7/PSMB8 Antibody [NB120-3329] - Analysis of HeLa cell extract. (novusbio.com)
Tissue: Heat Shocked Cervical cancer cell line (HeLa). (qedbio.com)
In a single-well setup we used the reporter in HeLa cells to screen a small molecule library of 33 000 compounds. (cancerindex.org)
Human wild-type HeLa cell line ( ab255928 ). (abcam.com)

Our current research now focuses on two basic, interrelated questions: (1) How do mammalian cells decide where and when to initiate DNA replication? (nih.gov)
Drugs that block DNA replication can arrest the spread of cancer cells and eliminate viral pathogens. (nih.gov)
Therefore, the overall goal of our work is to discover how DNA replication is regulated both in the large chromosomes of cells and in the "mini-chromosomes" of viruses and small extrachromosomal DNA molecules. (nih.gov)
In the past, our research focused on viral genomes as models for DNA replication in mammalian cell nuclei. (nih.gov)
We used isolated nuclei from virus infected cells supplemented with cytoplasm, and discovered that viral replicating chromosomes could continue replication in the absence of a nucleus. (nih.gov)

We want to understand how this regulation affects the organization and dynamics of the cell nucleus, and how it contributes to the maintenance of genome integrity. (google.com)

The major events in the regulation of the host response on a transcriptional level occur within the first 3 days after infection. (biomedcentral.com)
Transcriptional regulation, development and diseases in mammals. (mcb-seattle.edu)
By screening for proteins that colocalize with NHR-67 punctae, we identified new regulators of uterine cell fate maintenance: homologs of the transcriptional co-repressor Groucho (UNC-37 and LSY-22), as well as the TCF/LEF homolog POP-1. (elifesciences.org)
The work will be of interest to developmental biologists studying transcriptional control of cell fate specification in animals, especially once issues around the functional significance of the NHR-67 contiaining punctae are resolved. (elifesciences.org)

INTRODUCTION: Proteins that undergo receptor-mediated endocytosis are subject to lysosomal degradation, requiring radioiodination methods that minimize loss of radioactivity from tumor cells after this process occurs. (duke.edu)

they are not inherited and are present only in tumor cells. (medlineplus.gov)
within a given tumor, cells may be variably arranged in broad sheets, nests, trabeculae, true papillae, or pseudopapillae (see the first 3 images below). (medscape.com)
at least focally, tumor cells often have abundant clear cytoplasm, mimicking clear cell RCC. (medscape.com)

Co-staining for an epithelial cell marker identified most WUPyV viral protein 1-positive cells as respiratory epithelial cells. (cdc.gov)

We found that 75 mg/kg modafinil increased Fos immunoreactivity in the tuberomammillary nucleus (TMN) and in orexin (hypocretin) neurons of the perifornical area, two cell groups implicated in the regulation of wakefulness. (jneurosci.org)
This low dose of modafinil also increased the number of Fos-immunoreactive (Fos-IR) neurons in the lateral subdivision of the central nucleus of the amygdala. (jneurosci.org)
Although spontaneous changes of [Ca 2+ ] i have been examined in immature cortical neurons, the calcium dynamics of cortical precursor cells have received less attention. (jneurosci.org)
Immunohistochemical staining confirmed that these events occurred primarily in precursor cells rather than in postmitotic neurons. (jneurosci.org)

Description Western blot analysis of Human Cell line lysates showing detection of HSP90 protein using Rabbit Anti-HSP90 Polyclonal Antibody (11107). (qedbio.com)
Whole cell lysates were probed for NF-κB and IκB family proteins by immunoblot. (biomedcentral.com)

Moreover, some studies demonstrated that LAPTM5 was highly expressed in malignant B lymphomas and involved in B cell malignancies ( 10 ), involving in negative regulation of cell surface T and B cell receptor by promoting lysosome degradation ( 6 ). (spandidos-publications.com)
T-cell receptor (TCR)-induced IL-2 expression is suppressed at the level of mRNA and protein following chronic culture of T cells with tumour necrosis factor (TNF) at picomolar concentrations, an effect that is reversible upon removal of TNF. (biomedcentral.com)
Clark JM, Annenkov AE, Panesar M, Isomäki P, Chernajovsky Y, Cope AP: T cell receptor zeta reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor alpha. (biomedcentral.com)
The cell-free media from MWCNT-polarized macrophages induced the migration of neutrophilic cells (differentiated from HL-60), which was blocked by Acebilustat, a specific leukotriene A4 hydrolase inhibitor, or LY239111, an LTB4 receptor antagonist, but not NS-398, a cyclooxygenase 2 inhibitor, revealing LTB4 as a major mediator of neutrophil chemotaxis from MWCNT-polarized macrophages. (cdc.gov)
5. Carlezon, W.A. Jr. & Wise, R.A. Rewarding actions drug to its receptor, but rather by the rats, treatments associated with aversive of phencyclidine and related drugs in nucleus ac- failure of an expected drug injection to states such as severe drug withdrawal cumbens shell and frontal cortex. (lu.se)

Covers principle molecular mechanisms responsible for tumor initiation and progression, with a specific emphasis on intracellular signaling, DNA repair, cell cycle checkpoints, and loss of normal tissue homeostasis. (mcb-seattle.edu)

Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)

GSH accumulation in the nucleus is triggered in Arabidopsis cells in culture by treatments that synchronize cells at G1/S as identified by flow cytometry and marker transcripts. (cam.ac.uk)
However, the accumulation of senescent cells can have detrimental consequences, such as in age-related pathologies. (rupress.org)

Rab GTPases, tethering factors, and retromer) that transport cargo through endosomes and deliver it to lysosomes or recycle it back to the cell surface, and the signals and mechanisms governing these sorting decisions. (cshlpress.com)
We are studying the mechanisms by which chronic TNF suppresses T-cell responses in the CD4 + mouse T-cell hybridoma clone, 11A2. (biomedcentral.com)
These regulations do not the exposure with the potential health effects or address explicitly the question regarding return mechanisms. (who.int)

Background Hsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. (qedbio.com)

Regulation can occur through modification of the p27 protein's structure, its interaction with other proteins, or its localization within the cell. (medlineplus.gov)
Protein subcellular localization and conserved motif analysis showed soybean KRP proteins located in the nucleus, and the C-terminal protein sequence was highly conserved. (bvsalud.org)
Here we introduce in turn each of the three Type II PIPkins, and discuss what we know about their localization, their regulation and their function. (silverchair.com)

However, the initial rate of decay was similar in control and TNF-treated cells, suggesting that reduced expression in TNF-treated cells was not due to decreased stability of IL-2 mRNA. (biomedcentral.com)

Modulation of intracellular free calcium concentration ([Ca 2+ ] i ) may be part of the signaling pathway by which both local environmental factors and cell autonomous developmental programs influence corticogenesis. (jneurosci.org)
In this seminar, I will show how the intracellular redox state was modulated during the growth cycle and discuss the interplay between the major redox pyridine nucleotides, glutathione and ascorbate pools (Pellny et al. (cam.ac.uk)
The relationships between the intracellular glutathione pools, poly (ADP-ribose) polymerase (PARP) activities and the abundance of PARP1 and PARP2 mRNAs, will be discussed in terms of the regulation of growth and defence. (cam.ac.uk)

In vitro tracheary element transdifferentiation of Col-0 suspension cells. (or.jp)
In vitro diagnostics (IVD) companies today are facing a number of challenges related to FDA regulation of their products and tests. (hpm.com)

The phosphorylation of the sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) plays a key role in the regulation of renal phosphate transport by parathyroid hormone (PTH) and dopamine. (duke.edu)
Renal cell carcinoma (RCC) incidence has increased over the past two decades. (hindawi.com)
Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
although it is derived from cells of the renal tubular epithelium, it has several histological subtypes which differ in their clinical outcome and biological features. (hindawi.com)

The Atasf1ab mutant plants exhibit cell number reduction, S-phase delay/arrest, and reduced polyploidy levels. (nih.gov)
Moreover, cell cycle arrest at G0/G1 phase was triggered by decreased LAPTM5 as well, which could lead to delayed BCa cell growth. (spandidos-publications.com)

During EMT, cells will undergo transformation from epithelial phenotype to mesenchymal phenotype ( 14 ) and many characteristics of cells will change including loss of cell-cell adhesion and acquisition of aggressive and metastatic ability ( 15 ). (spandidos-publications.com)
In this work, Chatterjee and the team screened the effect of CKAP5 silencing in solid cancer cell lines and in normal non-cancer epithelial cell lines as a negative control. (medicalxpress.com)

Ghrelin cells are not terminally differentiated in the pancreas: they are progenitor cells that can give rise to A-cells, PP cells and Beta-cells there. (wikipedia.org)

3 Myelofibrosis (MF) refers to the Philadelphia chromosome ( BCR-ABL1 )-negative myeloproliferative neoplasm (MPN) originating at the level of the multipotent hematopoietic stem cell. (haematologica.org)

Anatomy53

Organisms13

Diseases3

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes77

Disciplines and Occupations1

Information Science3

Health Care2

Proliferation13

Localized in the cytoplasm2

Membrane12

Signal transduction4

Receptors6

Blocking cell cycle progression1

Cytoplasm into the nucleus2

Apoptosis7

Mitosis10

Chromatin4

Positive regulation1

Pathways8

Metabolism3

Cellular12

Differentiation3

Transcription7

Regulate4

Cytoskeleton1

Block cell cycle progression2

Freeze-thaw cycles1

Biology8

Gene5

Murine2

Kinase6

Nuclear6

Genes4

Participates2

Hypothalamic2

Translocation5

HeLa4

Replication5

Genome integrity1

Transcriptional4

Occurs1

Tumor cells3

Viral1

Neurons4

Lysates2

Receptor5

Molecular1

Malignant2

Accumulation2

Mechanisms3

Eukaryotic cells1

Localization3

MRNA1

Intracellular3

Vitro2

Renal4

Arrest2

Epithelial2

Terminally differentiated1

Chromosome1