• The cover art of the February 4th issue of Biophysical Journal highlights LLPS of histone proteins and chromatin in the cell nucleus using a minimalist and abstract representation. (biophysics.org)
  • Now, a team of investigators from the Northwestern University Center for Cancer Nanotechnology Excellence (Northwestern CCNE) has developed star-shaped nanoparticle that can deliver a drug directly to a cancer cell's nucleus an important feature for many potential anticancer therapies. (nanowerk.com)
  • The Northwestern CCNE team, led by Teri Odom, also reported that it was able to directly image at nanoscale dimensions how nanoparticles interact with a cancer cell's nucleus. (nanowerk.com)
  • They are attracted to a protein on the cancer cell's surface that conveniently shuttles the nanostars to the cell's nucleus. (nanowerk.com)
  • The ability to place these nanoparticles into a cell's nucleus and gather information using light has potential implications for the selective treatment of disease," Gregas said. (medica-tradefair.com)
  • We envision that this approach will also help basic scientists as they try to better understand what occurs within a cell's nucleus. (medica-tradefair.com)
  • Fluorescence emission intensity from a culture of human lung cells ( MRC-5 line) stained with MitoTracker Red CMXRos and Alexa Fluor 488 conjugated to phalloidin, which target the intracellular mitochondrial network and cytoskeletal actin filaments, respectively. (microscopyu.com)
  • In this paper we present a two-stage graph cut based model for segmentation of touching cell nuclei in fluorescence microscopy images. (springer.com)
  • However, much less is understood regarding the spatial organization of these events within the three-dimensional context of the mammalian cell nucleus. (rupress.org)
  • The use of increasingly sophisticated molecular techniques and the availability of a large number of antibodies and also nucleic acid probes has advanced our understanding of the temporal and spatial organization of nuclear functions, as well as revealed the complex nature of the mammalian cell nucleus. (rupress.org)
  • Researchers have published a cellular delivery method of nanoparticles called quantum dots which could be used as molecular probes for simultaneous imaging and manipulation of single biomolecules in the nucleus and for observation of subnuclear structures and events in the Oct. 4 edition of Small . (healthimaging.com)
  • Dr. Odom and her collaborators published their results in the journal ACS Nano ( 'Direct observation of nanoparticle cancer cell nucleus interactions' ). (nanowerk.com)
  • Once we can get that nanoparticle into the nucleus, we have many options. (medica-tradefair.com)
  • Yu worked with fellow mechanical science and engineering professor Ning Wang, PhD, and postdoctoral researcher Kyungsuk Yum, PhD, to develop a controlled delivery and release method that uses a cargo-carrying nanoneedle (serving also as a nanoscale electrode) to penetrate into the nucleus of a living cell. (healthimaging.com)
  • Our ultimate goal is to develop a nanoscale delivery system that can drop off its payload - in this case nanoparticles with other agents attached - into a cell to enhance the effectiveness of a drug treatment," Vo-Dinh said. (medica-tradefair.com)
  • The researchers then direct ultrafast pulses of light -- similar to that used in LASIK surgery -- at the cells. (nanowerk.com)
  • Since this initial research on human ovarian and cervical cancer cells, the researchers have gone on to study effects of the drug loaded gold nanostars on 12 other human cancer cell lines. (nanowerk.com)
  • To rapidly release the attached cargo inside the nucleus, the researchers applied a small external electrical potential through the nanoneedle. (healthimaging.com)
  • The researchers coupled miniscule particles of silver, a metal that is not rejected by cells and is an efficient reflector of light, with a small portion of the HIV protein responsible for its highly efficient ability to enter a cell and its nucleus. (medica-tradefair.com)
  • Using silver nanoparticles cloaked in a protein from the HIV virus that has an uncanny ability to penetrate human cells, the scientists have demonstrated that they can enter the inner workings of the nucleus and detect subtle light signals from the "spy. (medica-tradefair.com)
  • Between 1877 and 1878, Oscar Hertwig published several studies on the fertilization of sea urchin eggs, showing that the nucleus of the sperm enters the oocyte and fuses with its nucleus. (wikipedia.org)
  • Ernst Haeckel, the famed proponent of embryonic recapitulation, contended even in 1877: "the cell consists of matter called protoplasm, composed chiefly of carbon, with an admixture of hydrogen, nitrogen and sulphur. (apologeticspress.org)
  • Which of the following organelles is not present in an animal cell? (enotes.com)
  • Perhaps these new advances constitute substantial progress in scientific examination of cellular life, but they certainly are not the first observations of incredibly sophisticated organization in the cell. (apologeticspress.org)
  • Indeed, to observe cells at all is to observe strict organization in the human body itself, for the body is composed in a hierarchy of organs, tissues, and cells. (apologeticspress.org)
  • Reports of cellular organization do not surprise creationists, who understand that each cell is built according to fundamental design principles. (apologeticspress.org)
  • Associations between distinct pre-mRNA splicing components and the cell nucleus. (nih.gov)
  • This new method of getting into and detecting exactly what is going on in the nucleus of cell has distinct advantages over current methods," said Molly Gregas, a graduate student in the laboratory of Tuan Vo-Dinh, R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering, professor of chemistry and director of The Fitzpatrick Institute for Photonics at Duke's Pratt School of Engineering. (medica-tradefair.com)
  • The scientists developed a probability map for the nucleus and determined that CBP pockets are more likely to be located closest to the gene regions with which they are known to modify ("Scientists Prove. (apologeticspress.org)
  • Nucleoplasm : Contain a variety of particles with other molecules involved in maintenance and development of the cell. (scribd.com)
  • Applying watershed algorithms to the segmentation of clustered nuclei. (springer.com)
  • We present an automated cell nuclei segmentation approach that works with H&E-stained images. (spiedigitallibrary.org)
  • Using a morphological operation and thresholding technique on the hematoxylin channel image, candidate target nuclei and background regions were detected, which were then used as markers for a marker-controlled watershed transform segmentation algorithm. (spiedigitallibrary.org)
  • Experimental results show that the proposed method can lead to promising results in terms of segmentation accuracy and separation of touching nuclei. (spiedigitallibrary.org)
  • First, it binds to nucleolin, a protein overexpressed in cancer cells and found both on the cell surface and within the cell nucleus. (nanowerk.com)
  • Using an electron microscope, Odom and her team found their drug loaded nanoparticles dramatically change the shape of the cancer cell nucleus. (nanowerk.com)
  • One of the most promising applications of quantum dots is molecular imaging in living cells, according to Min-Feng Yu, PhD, associate professor of mechanical science and engineering, University of Illinois at Urbana-Champaign, and colleagues. (healthimaging.com)
  • Satellite cells are responsible for the capacity of mature mammalian skeletal muscles to repair and maintain mass. (hindawi.com)
  • 2006). Systems biologists worked with mathematicians to identify, for the first time, "spatial relationships" governing the distribution of an important control protein in the nucleus, in relation to other components within the nuclei of mammal cells ("Scientists Prove. (apologeticspress.org)
  • Cell nucleus is the central unit of the cell, where it control activity of the cell. (omicsonline.org)
  • The nucleus is designed to govern and control everything that happens within the entire cell, which includes the process of cell division. (reference.com)
  • Leveraging a new approach, the research team turned their attention from the cell's periphery to the nucleus - the very place that unleashes sweeping damage-control responses which, if left unchecked, ultimately destroy the heart. (sciencecodex.com)
  • Bound to the nucleolin, the drug loaded gold nanostars take advantage of the protein's role as a shuttle within the cell and hitchhike their way to the cell nucleus. (nanowerk.com)
  • New research suggests that the nucleus of a mammal cell is made up of component parts arranged in a pattern which can be predicted statistically ("Scientists Prove. (apologeticspress.org)
  • Franz Meyen was a strong opponent of this view, having already described cells multiplying by division and believing that many cells would have no nuclei. (wikipedia.org)
  • What Is the Division of the Cell Nucleus Called? (reference.com)
  • Meiosis is a type of cell nucleus division specific to the reproduction of the species. (reference.com)
  • Cells that "spit" out their contents and messenger RNA that is not so swift at delivering its message. (scienceblogs.com)
  • The first story arose from a simple question: How do secretory cells - those that produce copious amounts of such substances as tears, saliva or all those bodily fluids - manage to get their contents out of the cell? (scienceblogs.com)
  • Nanowerk News ) While a great deal of the potential for nanotechnology to improve cancer therapy lies with the ability of nanoparticles to deliver drug payloads directly to tumors, an equally important consideration is whether nanoparticles can then get their drug payload to their intended target inside tumor cells. (nanowerk.com)
  • We can for example deliver some sort of payload and then observe its effects within the nucleus. (medica-tradefair.com)
  • In the current edition of Molecular Cell, scientists from the Helmholtz Zentrum München describe how cells "decide" which of these two directions to take. (bionity.com)
  • The manner in which some viruses inject their DNA into bacteria or other types of cells, appears to be much simpler than scientists had previously thought. (bionity.com)
  • Although some 17th-century scientists realized how ridiculous it would be to suggest that something as obviously structured as a human body was composed of randomly assembled components, they did not understand fully the complexity of the cell. (apologeticspress.org)
  • Schematic of typical animal cell, showing subcellular components. (wikidoc.org)
  • Although snRNP antigens are also concentrated in these nuclear regions, we show that the two types of spliceosome components are localized through different molecular interactions: The distribution of SC-35 was not affected by treatment with DNase I or RNase A, or when the cells were heat shocked. (nih.gov)
  • While it's been known for many years that the nucleus goes awry in heart failure, potential therapeutic targets residing in this part of the cell are often dubbed as 'undruggable' given their lack of pharmacological accessibility," said Jonathan Brown, MD, cardiologist at Brigham and Women's Hospital and co-first author on the paper. (sciencecodex.com)
  • For each segmented region from the previous steps, the regional maximum value positions were identified as potential nuclei centers. (spiedigitallibrary.org)
  • However essential a pillar of evolution the random may be, it is antithetical to what we actually observe in nature, even in the basic unit of all living matter-the cell (Aw, 1982, p. 127). (apologeticspress.org)