• The authors identified a domain within VHL that detects increased acidity, such as occurs during hypoxia, and somehow induces VHL to move to the nucleolus from the cytoplasm and nucleoplasm, where it normally resides. (rupress.org)
  • It surrounds the cytoplasm of a cell, and physically separates the inner cellular components from the outter cellular enviroment. (protopage.com)
  • Cytoplasm is a semi-transparent fluid that fills most cells. (protopage.com)
  • Cell expansion, growth and replication are carried out in the cytoplasm of the cell. (protopage.com)
  • plump polyhedral nevus cells: Abundant cytoplasm is filled with pigment and has a small round to oval nucleus with bland appearance. (aao.org)
  • slender spindle nevus cells (Fig 12-16): The cytoplasm contains scant pigment and a small, dark, elongated nucleus. (aao.org)
  • balloon cells: Abundant, foamy cytoplasm lacks pigment and has a bland nucleus. (aao.org)
  • Histologically, a melanocytoma is composed of large polyhedral cells with small round to oval nuclei and abundant cytoplasm. (aao.org)
  • Epithelioid melanoma cells resemble epithelium because of their abundant eosinophilic cytoplasm and enlarged round to oval nuclei. (aao.org)
  • Note the balloon cells (arrowheads) with abundant foamy cytoplasm. (aao.org)
  • Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)
  • Ones found freely in cytoplasm or as part of the Rough endopl-asmic reticulum in Eukaryotic cells. (cheatography.com)
  • Histologic sections show small nests of cytologically bland epithelial cells with abundant clear to eosinophilic cytoplasm distributed within a fibromatous stroma. (cap.org)
  • The epithelial cells have a urothelial cell-like appearance, with abundant clear to pale eosinophilic cytoplasm and small nucleoli. (cap.org)
  • Located in cytoplasm and nucleolus. (jax.org)
  • Like a prokaryotic cell, a eukaryotic cell has a plasma membrane, cytoplasm, and ribosomes. (coursehero.com)
  • Membraneless intracellular compartments formed through liquid-liquid phase separation from the surrounding CYTOPLASM or nucleoplasm or by the concentration of proteins and nucleic acids into droplets as they aggregate on static cellular structures such as CELL MEMBRANES. (bvsalud.org)
  • Binucleate or multilobated cells with abundant cytoplasm, large eosinophilic nucleoli, which can be round or linear, surrounded by a clear halo. (medscape.com)
  • Large mononuclear cells, their nucleoli tend to be basophilic rather than eosinophilic and their cytoplasm is basophilic/amphophilic rather than eosinophilic. (medscape.com)
  • In spindle-B melanoma cells, coarse, granular chromatin and plump, large nuclei are seen. (aao.org)
  • Their nuclei have a conspicuous nuclear membrane, very coarse chromatin, and large nucleoli. (aao.org)
  • In eukaryotes, DNA is packed inside the cell nucleus in the form of chromatin, which consists of DNA, proteins such as histones, and RNA. (nature.com)
  • However, in most cases there are specific features that may aid in differentiating small reactive from non-reactive lymphocytes including the round shape of the nucleus, the absence of visible nucleoli and the presence of fine clumped chromatin. (cytojournal.com)
  • Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
  • The nucleoplasm is the semi-solid fluid inside the nucleus where we find the chromatin and the nucleolus. (coursehero.com)
  • The nucleus stores chromatin (DNA plus proteins) in a gel-like substance called the nucleoplasm.The nucleolus is a condensed region of chromatin where ribosome synthesis occurs.The boundary of the nucleus is called the nuclear envelope.It consists of two phospholipid bilayers: an outer membrane and an inner membrane.The nuclear membrane is continuous with the endoplasmic reticulum.Nuclear pores allow substances to enter and exit the nucleus. (coursehero.com)
  • Endocervical smear: sheet of atypical cells of glandular type with enlarged nuclei and a regular chromatin pattern. (iarc.fr)
  • Fig. 2A ]) Their nuclei were round to oval with inconspicuous nucleoli and finely dispersed chromatin. (thieme-connect.com)
  • the chromatin and the nuclear-cellular ratio (N/C) of each plasma cell. (bvsalud.org)
  • Cell nucleus Nucleoid McStay B (2016). (wikipedia.org)
  • Nucleolus Function: The nucleolus is a round body located inside the nucleus of a eukaryotic cell. (theeducationlife.com)
  • The nucleus of the plant cell is on the inside of the plant cell in most opinions is the brain and power behind the cell. (protopage.com)
  • The nucleolus is a sub-organelle of the cell nucleus though itself is a nucleus. (protopage.com)
  • The jellylike material outside the cell nucleus in which the organelles are located. (enchantedlearning.com)
  • The nucleus controls many of the functions of the cell (by controlling protein synthesis) and contains DNA (in chromosomes). (enchantedlearning.com)
  • The nucleus and nucleoli are on the left. (cellimagelibrary.org)
  • Positional cloning of the RID2 gene revealed that it encodes an evolutionarily conserved methyltransferase-like protein, which was found to localize in the nucleus, with accumulation being most evident in the nucleolus. (nih.gov)
  • A eukaryotic cell has a true membrane-bound nucleus and has other membranous organelles that allow for compartmentalization of functions. (coursehero.com)
  • Eukaryotic cells are larger than prokaryotic cells and have a "true" nucleus, membrane-bound organelles, and rod-shaped chromosomes. (coursehero.com)
  • Typically, the nucleus is the most prominent organelle in a cell. (coursehero.com)
  • Eukaryotic cells have a true nucleus, which means the cell's DNA is surrounded by a membrane. (coursehero.com)
  • Figure 12-16 Spindle-cell choroidal nevus (between arrows) is composed of slender spindle-shaped cells with thin, homogeneously staining nuclei. (aao.org)
  • Spindle-A melanoma cells have slender, elongated nuclei with small nucleoli. (aao.org)
  • The nuclei are small and slightly irregular, with small nucleoli. (cap.org)
  • The cells are hyperchromatic, with pleomorphic nuclei and frequent mitotic figures. (cap.org)
  • Having complex cells in which the genetic material is organized into membrane-bound nuclei. (coursehero.com)
  • B. mori nuclear polyhedrosis virus (bacmid, conserved by our lab) was propagated in BmN cells. (hindawi.com)
  • Medulloblastoma is defined by the World Health Organization (WHO) as "an embryonal neuroepithelial tumor arising in the cerebellum or dorsal brainstem, presenting mainly in childhood and consisting of densely packed small round undifferentiated cells with mild to moderate nuclear pleomorphism and high mitotic count. (medscape.com)
  • 2 ] The ominous nuclear appearance of tumor cells could be misleading and pose a diagnostic difficulty. (thieme-connect.com)
  • The cytoplasmic melanin content in melanoma cells can vary considerably. (aao.org)
  • In 17 cases reaction was restricted to the nucleoli, in 4 cases additional cytoplasmic staining was observed. (ox.ac.uk)
  • The anti-IL-2 staining of nucleoli in AML cells is distinct from the cytoplasmic staining which is observed in PHA-activated normal lymphocytes and in a minority of AML cells. (ox.ac.uk)
  • In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
  • Nucleoli are prominent. (aao.org)
  • Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
  • In some areas, the tumor cells were small and uniform resembling pinealocytes, and arranged in sheets and at places forming pineocytomatous rosettes with abundant delicate tumor cell processes. (thieme-connect.com)
  • There are also DNA sequences related to rDNA that are on other chromosomes and may be involved in nucleoli formation. (wikipedia.org)
  • The chromosomes are located inside the cell. (protopage.com)
  • Aneuploidy is an abnormality in the number of chromosomes in a cell due to loss or duplication. (genome.gov)
  • Here we show, however, that RNA polymerase II (Pol II) inside human nucleoli operates near genes encoding rRNAs to drive their expression. (nature.com)
  • MDM2, an E3 that induces the degradation of the p53 tumor suppressor protein, also became fixed in the nucleolus in response to actinomycin-D treatment, which is known to block p53 ubiquitylation.The authors propose that such nucleolar sequestration, and more generally the concept of switching proteins between a mobile and static state, is likely to be a commonly used mechanism for regulating enzyme reactions. (rupress.org)
  • however, a tumor consisting entirely of spindle-A cells is considered a nevus. (aao.org)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • Seminoma is the most common pure germ cell tumor (GCT) of the testis, accounting for up to 50% of cases. (medscape.com)
  • Overall, 60% of germ cell neoplasms have seminoma in their composition, but pure seminomas are genetically different from those that present as a component of a mixed tumor. (medscape.com)
  • Less frequently, a tubular morphology can be seen (see the images below), posing a differential diagnosis with Sertoli cell tumor. (medscape.com)
  • Many factors, such as peroxide, ox-low density lipoprotein (LDL), angiotensin I, and tumor-necrosis-factor-(TNF-) α can induce the production of reactive oxygen species (ROS) by NADPH oxidase in endothelium and vascular smooth muscle [ 2 ], which results in oxidative stress to the endothelial cells (ECs) and, thus, the induction of cell apoptosis. (hindawi.com)
  • The symptoms of meningioma can be flared by water retention, engorgement of blood vessels , and the presence of sex hormone receptors on tumor cells. (wikidoc.org)
  • Papillary tumor of the pineal region (PTPR) is a neuroectodermal tumor thought to originate from cells of the subcommissural organ. (thieme-connect.de)
  • Originally described by Headington in the 1970s, trichoblastoma (TBL) is now appreciated as a rare benign tumor that originates from the follicular germ cell line [1, 2]. (karger.com)
  • Tumors with skeletal muscle differentiation and malignant Schwann cells are classified as a subtype or a histologic variant of MPNST [ 9 , 10 ] and are referred to as malignant triton tumor (MTT) [ 11 ]. (hindawi.com)
  • The first was that Schwann cells in neurogenic tumor could be stimulated by motor nerve to differentiate into rhabdomyoblastic component. (hindawi.com)
  • The tumor cells were negative for glial fibrillary acidic protein (GFAP), placental alkaline phosphatase (PLAP), Human Chorionic Gonadotropin (HCG), and pan-cytokeratin. (thieme-connect.com)
  • CD-117-Numerous mast cells exhibiting faint positivity are seen interspersed in the tumor. (thieme-connect.com)
  • 1% proliferation index in tumor cells. (thieme-connect.com)
  • There is only 1 in each cell and it transports protein around. (protopage.com)
  • cell membrane - the thin layer of protein and fat that surrounds the cell, but is inside the cell wall. (enchantedlearning.com)
  • Dr. Pryciak studies how protein kinases regulate cell signaling and the cell cycle. (umassmed.edu)
  • A novel 5S RNA-protein (RNP) complex in human and mouse cells has been analyzed using patient autoantibodies. (nih.gov)
  • In a cell, antisense DNA serves as the template for producing messenger RNA (mRNA), which directs the synthesis of a protein. (genome.gov)
  • Scientists found that the protein named reelin is deeply involved in the migration of new nerve cells to the neocortex. (neurosciencenews.com)
  • Research involving programmed cell death has lead to new information about the involvement of a protein named FLIP in cell. (neurosciencenews.com)
  • Storage protein 2 (SP2) not only is an important source of energy for the growth and development of silkworm but also has inhibitory effects on cell apoptosis. (hindawi.com)
  • A recent study showed that another protein in silkworm hemolymph, storage protein 2 (SP2), can also inhibit staurosporine-induced HeLa cell apoptosis and ROS generation [ 8 ]. (hindawi.com)
  • the expression levels of protein associated with apoptosis and endoplasmic reticulum stress (ERS) of SKO-007 cells in various groups were detected by Western blotting method. (researchgate.net)
  • Objective: To investigate the effects of prion protein 106-126 peptide on inducing apoptosis in differentiated PC12 cells. (researchgate.net)
  • Methods: After differentiated by nerve growth factor (NGF), the PC12 cells were infected by prion protein 106-126 peptide. (researchgate.net)
  • Conclusion: Prion protein 106-126 peptide can induce apoptosis in differentiated PC12 cells and present cellular toxicity definitely. (researchgate.net)
  • The distal flanking junction (DJ) of the NORs has been shown to associate with the periphery of nucleoli. (wikipedia.org)
  • The Science Explorer interviews Angeline Lim, an Applications Scientist at Molecular Devices, to learn more about Cell Painting and the impact it is having on cell biology research and drug discovery. (moleculardevices.com)
  • Additional studies have also shown that hemolymph from the silkworm ( Bombyx mori ) can inhibit insect and mammalian cell apoptosis that is induced by viruses and several chemical inducers, such as staurosporine, camptothecin, and actinomycin D [ 6 - 8 ]. (hindawi.com)
  • The cell wall is a fairly rigid layer surrounding a cell, located external to the cell membrane, which provides the cell with structural support, protection, and acts as a filtering mechanism. (protopage.com)
  • The cell membrane is a lipid bilayer that contains a wide variety of molecules mostly proteins and lipids. (protopage.com)
  • A rhenium polypyridine-based molecular vessel is membrane impermeant when empty, but, upon loading with metal ions, the cationic form is taken up by MCF-7 cells, localising in nucleoli. (cardiff.ac.uk)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • The cell membrane is semipermeable, allowing some substances to pass into the cell and blocking others. (enchantedlearning.com)
  • A thick, rigid membrane that surrounds a plant cell. (enchantedlearning.com)
  • The golgi body packages proteins and carbohydrates into membrane-bound vesicles for "export" from the cell. (enchantedlearning.com)
  • Rough ER transport materials through the cell and produces proteins in sacks called cisternae (which are sent to the Golgi body, or inserted into the cell membrane). (enchantedlearning.com)
  • Part of the chloroplasts in plant cells, located within the inner membrane of chloroplasts, between the grana. (enchantedlearning.com)
  • Subcellular localization results showed that SP2 is located mainly on the cell membrane. (hindawi.com)
  • Other than the fact that vacuoles are somewhat larger than vesicles, there is a very subtle distinction between them: the membranes of vesicles can fuse with either the plasma membrane or other membrane systems within the cell. (coursehero.com)
  • Positively charged molecules are usually cell membrane permeable and accumulate in mitochondria. (dojindo.com)
  • Since it has an amine-reactive succinimidyl group, fluorescein derived from CFSE can covalently bond to proteins or other amino groups in the cell or on the cell membrane. (dojindo.com)
  • Several E3 proteins aggregate in the nucleolus in response to inhibitory signals. (rupress.org)
  • Although nucleolar proteins involved in ribosome synthesis move in and out of the structure constantly, the authors saw that VHL was static in the nucleolus, based on FRAP, FLIP, and heterokaryon experiments. (rupress.org)
  • The Golgi Apparatus sorts, modifies, and packages proteins and other materials from the endoplasmic reticulum for storage in the cell or secretion outside the cell. (protopage.com)
  • The endoplasmic reticulum translates proteins and transports items throughout the cell. (protopage.com)
  • Ribosomes assemble proteins and polypeptides for cell division. (protopage.com)
  • We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)
  • The most commonly stained cell components are cell membranes, proteins, and nucleotides. (dojindo.com)
  • These compounds are neutral molecules that pass through cell membranes and covalently conjugate with cell proteins. (dojindo.com)
  • L5 may therefore play a role in delivering 5S rRNA to the nucleolus for assembly into ribosomes. (nih.gov)
  • Outside nucleoli, Pol III synthesizes 5S rRNA molecules that are targeted to nucleoli for processing. (nature.com)
  • Small neutral molecules and positively charged molecules can pass through viable cell membranes and remain inside of cells, depending on their reactivity or hydrophilicity. (dojindo.com)
  • Negatively charged molecules cannot pass through viable cell membranes. (dojindo.com)
  • Ester can pass through viable cell membranes, where it is hydrolyzed by cellular esterases into a negatively charged molecule under physiological conditions. (dojindo.com)
  • CFSE is also an ester compound that passes through viable cell membranes. (dojindo.com)
  • MitoRed and Rh123 readily pass through cell membranes and accumulate in mitochondria. (dojindo.com)
  • Cell membranes of viable cells are impermeable to these fluorescent dyes,except for the Hoechst dyes, and these dyes can therefore be used as fluorescent indicators of dead cells. (dojindo.com)
  • Hoechst dyes are positively charged under physiological conditions and can pass through viable cell membranes. (dojindo.com)
  • The nucleolus is responsible for the production and the assembly of the ribosomes. (protopage.com)
  • A specialized structure found inside cells that carries out a specific life process (e.g. ribosomes, vacuoles). (coursehero.com)
  • The Mitochondria holds the DNA and the RNA of the plant cell. (protopage.com)
  • There are hundreds of mitochondria in a plant cell and it also converts glucose into energy. (protopage.com)
  • In plant cells, ATP is produced in the cristae of mitochondria and chloroplasts. (enchantedlearning.com)
  • Mitochondria exist in most eukaryotic cells and play a very important role in oxidative metabolism by generating ATP as an energy source. (dojindo.com)
  • The average number of mitochondria per cell is from 100 to 2,000. (dojindo.com)
  • Although the typical size is about 0.5-2 mm, the shape, abundance, and location of mitochondria vary by cell type, cell cycle, and cell viability.Therefore, visualization of mitochondra is important. (dojindo.com)
  • We reveal a nucleolar Pol-II-dependent mechanism that drives ribosome biogenesis, identify disease-associated disruption of nucleoli by noncoding RNAs, and establish locus-targeted R-loop modulation. (nature.com)
  • Binding of monoclonal anti-interleukin 2 antibody to nucleoli in acute leukemia blast cells. (ox.ac.uk)
  • Neutralizing anti-IL-2, anti-IL-3, and anti-IL-6 monoclonal antibodies (MAbs) were used for the immunoenzymatic detection of the respective cytokines in blast cells of 38 patients with acute myeloid (AML) and lymphoid (ALL) leukemias by the APAAP-technique. (ox.ac.uk)
  • Multiple Myeloma Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)
  • Fluorescent staining using CTC is another method used to detect viable bacterial cells. (dojindo.com)
  • The advantage of this method is very quick detection and the possibility of detecting VNC (viable but non-culturable) bacterial cells. (dojindo.com)
  • The phenotypes of rid2-1 in tissue culture and in seedlings indicated that the rid2 mutation has various (acute and non-acute) inhibitory effects on different aspects of cell proliferation. (nih.gov)
  • The ____ of each human cell contains 23 chromosome pairs. (quizhub.com)
  • This suggests that the RID2 function is not directly involved in every cycle of cell division, but is related to 'vitality', supporting cell proliferation. (nih.gov)
  • Overview of Cancer Cancer is an unregulated proliferation of cells. (msdmanuals.com)
  • Developmental processes are increasingly well-characterized at the molecular and cell biological levels, but how more complex tissues and organs involving. (neurosciencenews.com)
  • What would you say is the advantage of using Molecular Devices high-content imaging systems in particular for Cell Painting? (moleculardevices.com)
  • Methods: The human multiple myeloma SKO-007 cells in logarithm growth phase were selected and randomly divided into control group, LDM group, BZM group, and BZM combined with LDM group. (researchgate.net)
  • Objective: To identify the different types of plasma cells in multiple myeloma. (bvsalud.org)
  • Results: Morphological aspects of plasma cells of 55 cases of multiple myeloma from 2004 to 2010 were analyzed in two laboratories in Kinshasa. (bvsalud.org)
  • This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
  • Histologic subtypes of medulloblastoma include: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, and (3) large-cell/anaplastic medulloblastoma. (medscape.com)
  • Sure, so Cell Painting essentially is a high-content, image-based assay that you would use for morphological profiling. (moleculardevices.com)
  • In a Cell Painting assay you would use up to six fluorescent dyes to label different components of the cell. (moleculardevices.com)
  • I would say there are many, but some things to highlight would be that you could use any of our ImageXpress Micro systems in the imaging step for your Cell Painting assay. (moleculardevices.com)
  • They used our ImageXpress system to develop a Cell Painting assay. (moleculardevices.com)
  • A cell viability assay demonstrated that SP2 could significantly enhance the viability of HUVEC. (hindawi.com)
  • Cell viability was determined by using the MTT assay and the morphological changes were observed. (researchgate.net)
  • These esterase substrates, therefore, can serve as assay probes of cell viability. (dojindo.com)
  • Testing of IgG autoantibodies to human cellular antigens was performed by the HEp-2 cell immunofluorescence assay using slides from INOVA Diagnostics, San Diego, CA (Cat # 508100) following the manufacturer's instructions and evaluated primarily using their NOVA View system. (cdc.gov)
  • Here we combine theory and experiment to analyze the dynamics of euchromatin organization as pluripotent zebrafish cells exit mitosis and begin transcription. (nature.com)
  • Indirect immunofluorescence indicates that the L5/5S complex is concentrated in the nucleolus. (nih.gov)
  • To investigate whether Pol II exists within human nucleoli, we first used immunofluorescence coupled to super-resolution microscopy. (nature.com)
  • plump fusiform dendritic nevus cells: Morphology is intermediate between that of plump polyhedral and slender spindle. (aao.org)
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • To evaluate the survival of patients according to plasma cell morphology. (bvsalud.org)
  • All of these organelles are found in each and every eukaryotic cell. (coursehero.com)
  • Chloroplasts are extremely important organelles, and the more a cell has, the healthier and more efficient the plant is. (protopage.com)
  • Spherical body containing many organelles, including the nucleolus. (enchantedlearning.com)
  • These organelles are often called the "energy factories" of a cell because they are responsible for making adenosine triphosphate (ATP), the cell's main energy-carrying molecule, by conducting cellular respiration. (coursehero.com)
  • While all eukaryotic cells contain the aforementioned organelles and structures, there are some striking differences between animal and plant cells. (coursehero.com)
  • Cells are slightly larger than lymphocytes . (wikidoc.org)
  • rDNA operons in Escherichia coli have been found to cluster near each other, similar to a eukaryotic nucleolus. (wikipedia.org)
  • In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
  • The translocation t(11;14)(q13;q32) is considered the precipitating oncogenic event that induces cell cycle deregulation in mantle cell lymphoma due to overexpression of cyclin D1 . (wikidoc.org)
  • However, less commonly, mutations in CCDN2 and CCDN3 have also been identified in cases of mantle cell lymphoma lacking the t(11;14) translocation. (wikidoc.org)
  • Pleomorphic and blastic type(together known as the blastoid variant): The pleomorphic type are similar to diffuse large B-cell lymphoma ( DLBCL ). (wikidoc.org)
  • Scattered non-granumloma forming epithelioid macrophages , hyalinized vessels and a few reactive T cells or mast cells are seen along with the lymphoma cells in MCL . (wikidoc.org)
  • Follicular dendritic cells (FDC) are a hallmark of mantle cell lymphoma and may also be involved in its pathogenesis . (wikidoc.org)
  • Parkinson's disease may be caused by oxidative stress within cells due to defective nucleoli. (neurosciencenews.com)
  • During cell division (mitosis), the centrosome divides and the two parts move to opposite sides of the dividing cell. (enchantedlearning.com)
  • Animal cells have a centrosome and lysosomes while plant cells do not. (coursehero.com)
  • The Pederson lab researches RNA biosynthesis in the nucleolus. (umassmed.edu)
  • Due to the variety of cell types in the pineal region (pinealocytes, endothelial cells, nerve endings from sympathetic innervation, glial cells, and ependymal cells), numerous different neoplasms are found there. (medscape.com)
  • The RNP is small (approximately 7S) and contains most of the nonribosome-associated 5S RNA molecules in HeLa cells. (nih.gov)
  • Covalently conjugated molecules can stay in the cell for several weeks. (dojindo.com)
  • Calcein and BCECF can be converted into electrically neutral molecules by the addition of acetyl or acetoxymethyl groups to their phenolic OH or carboxylic groups, which allows them to freely permeate into the cell. (dojindo.com)
  • The Flores Kim lab studies how bacteria build their cell envelopes and how antimicrobials disrupt these processes. (umassmed.edu)
  • Cells regulate metabolic pathways by rigidly locking enzymes in the nucleolus, report Mekhail et al. (rupress.org)
  • Two ubiquitin ligase enzymes bind in the nucleolus in response to signals that block their activity. (rupress.org)
  • They contain enzymes that breakdown materials things in the cell. (protopage.com)
  • Distinction between atypical lymphoid proliferations rich in Reed-Sternberg-like cells (reactive immunoblasts) and classic Hodgkin lymphomas. (medscape.com)
  • Objective: To investigate the induction of tanshinone [1 A (Tan fl A) on the differentiation of human placenta-derived mesenchymal stem cells (hPDMSCs) into cardiomyocytes, and to provide an experimental basis for Tan IT A as a cardiomyocytc differentiation inducer. (researchgate.net)
  • Microtubules serve as structural components within cells and are involved in many cellular processes including mitosis, cytokinesis, and vescular transport. (protopage.com)
  • vesicle is a small and enclosed compartment within a cell. (protopage.com)
  • However, even these patients are at risk of dying from lung cancer (both small and non-small cell types). (cancer.gov)
  • B ) Higher power view demonstrating the presence of pineocytomatous rosettes (marked with an arrow head) interspersed with bizarre pleomorphic cells and numerous mast cells (marked with a thick arrow). (thieme-connect.com)
  • The second explanation was more plausible, where neoplastic Schwann cells can transform into rhabdomyoblasts, suggesting the possibility of some mesenchymal tissue derivation from neuroectodermal cells. (hindawi.com)
  • Fluorescent esterase substrates may also be used in cell viability assays in place of tetrazolium analogs such as MTT or WST. (dojindo.com)
  • Pineal neoplasms are typically classified as germ cell tumors (GCTs), pineal parenchymal cell tumors, tumors from adjacent structures, and other miscellaneous tumors and cysts. (medscape.com)
  • Non-germinomatous germ cell tumors (NGGCTs)-specifically, embryonal carcinomas, yolk sac tumors, and choriocarcinomas-are more aggressive. (medscape.com)
  • Genetic changes have also been studied in the past few decades, with documentation of aneuploid DNA content in seminomas and intratubular germ cell neoplasia of the unclassified type (IGCNU), the precursor lesion. (medscape.com)
  • However, GCTs, including seminomas, can occur in extragonadal sites along the midline of the body, following the embryologic migration route of its precursor cells -- the primordial germ cells. (medscape.com)
  • Apoptotic cells which nucleolus shrinked and rounded could be coloured orange by fluorescent colouration. (researchgate.net)
  • Visualization of a cell with fluorescent compounds provides a wide variety of information for the analysis of cell functions. (dojindo.com)
  • Various activities and structures of a cell can be targeted for staining with fluorescent compounds (Fig. 1). (dojindo.com)
  • Succinimidyl ester compounds can also be used to improve retention of the fluorescent derivative within the cell. (dojindo.com)
  • Nucleotide staining with fluorescent intercalators is mostly used for dead cell detection. (dojindo.com)
  • Once converted into fluorescent products by esterase, these compounds are retained by cells because of their negative charges. (dojindo.com)
  • PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
  • They are composed of irregular nests of malignant cells with stromal invasion, often associated with a desmoplastic reaction. (cap.org)
  • Diagnosis of TBL is challenging given its resemblance to basal cell carcinoma (BCC) but is important given possible malignant transformation and potential metastasis. (karger.com)
  • intermediate plasma cells and mature plasma cells. (bvsalud.org)