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  • dendritic cells
  • Adoptive transfer of splenocytes from transgenic mice immunized with CEA 576-669 -Hsp70L1-pulsed dendritic cells can inhibit tumor growth and prolong survival in nude mice bearing CEA + /HLA-A2.1 + human colon carcinoma more markedly. (aacrjournals.org)
  • Meanwhile, the complexes or HSPs in the complexes interact with dendritic cells and stimulate dendritic cells to express MHC class II molecules, to secrete cytokines and chemokines, resulting in maturation of dendritic cells with migration to draining lymph nodes where they present antigen to T cells and initiate T-cell responses ( 1 - 7 ). (aacrjournals.org)
  • magnetic resonance
  • The aim of this thesis was to identify potential metabolic biomarkers of CRC patients using 'Metabonomics' based on proton nuclear magnetic resonance (1H NMR) spectroscopy. (bl.uk)
  • cancer
  • CEA is overexpressed in approximately 70% of cases of non-small cell lung cancer (NSCLC), as well as more than 95% of adenocarcinomas of gastrointestinal origin [ 7 ]. (jcancer.org)
  • A fluorescence cystoscopy uses a dye (called a porphyrin) and a special light to help make cancer cells easier to see. (cancer.ca)
  • The doctor injects the porphyrin into the bladder and the cancer cells take it up. (cancer.ca)
  • The cancer cells that took up the porphyrin glow in the blue light. (cancer.ca)
  • The pathology report from the lab will confirm whether or not cancer cells are present in the sample. (cancer.ca)
  • The biopsy sample or tumour is examined under a microscope to look for bladder cancer and see how far the cancer cells have grown into the bladder wall (called the depth of invasion). (cancer.ca)
  • The overexpression of HOX lncRNA promotes cancer because it causes epigenetic regulator proteins to relocate and the chromatin of the cell to be remodeled. (wikipedia.org)
  • Less common types of ovarian cancer include germ cell tumors and sex cord stromal tumors. (wikipedia.org)
  • Environmental exposure to ionizing radiation from both natural background sources and artificial sources is suspected to play a significant role, and there are significant increased rates of thyroid cancer in those exposed to mantlefield radiation for lymphoma, and those exposed to iodine-131 following the Chernobyl, Fukushima, Kyshtym, and Windscale nuclear disasters. (wikipedia.org)
  • Follicular thyroid cancer (10% to 20% of cases) - occasionally seen in patients with Cowden syndrome Medullary thyroid cancer (5% to 8% of cases) - cancer of the parafollicular cells, often part of multiple endocrine neoplasia type 2. (wikipedia.org)
  • human
  • In the normal colonic mucosa or in other human intestinal cell lines, immunofluorescence labeling shows that DAF is expressed on the luminal surface of the epithelium ( 74 ) and at the brush border of polarized intestinal cells ( 5 ). (asm.org)
  • Proinflammatory cytokines can modulate DAF expression in various human cells ( 9 , 52 ). (asm.org)
  • A global approach profiling a large number of metabolites was undertaken in cell line and chemoprevention studies with subsequent targeted profiling experiments using human polypoid tissue samples. (bl.uk)
  • adenocarcinoma
  • Cytologic evaluation determined 1 case positive for malignancy (small cell lung carcinoma [SCLC]), 1 suspicious for adenocarcinoma, and 14 negative for malignancy. (cytojournal.com)
  • whereas
  • Soon it was shown that TK1 is present in the cytoplasm only in anticipation of cell division (cell cycle-dependent), whereas TK2 is located in mitochondria and is cell cycle-independent. (wikipedia.org)
  • occur
  • It has not been described as arising in locations outside the testis, and does not occur in association with other germ cell tumours. (wikipedia.org)
  • nucleoli
  • Histologically, the tumor showed two distinct components: 1) cystic and tubular structures lined by low columnar to cuboidal biliary-type epithelium, and 2) a dense fibrous stroma composed of spindle-shaped cells with only mild nuclear pleomorphism and inconspicuous nucleoli. (thedoctorsdoctor.com)
  • Histologically, spermatocytic seminomas consist of three cell populations: small cells with a large nuclear-to-cytoplasmic ratio (6-8 µm), medium-sized cells with prominent nucleoli (15-18 µm) and, large cells (50-100 µm). (wikipedia.org)
  • immunoreactivity
  • However, given the marked nuclear p53 immunoreactivity and tetraploidy status observed in this tumor, we cannot exclude that biliary adenofibroma may represent a premalignant process that warrants complete resection and thorough histopathologic examination. (thedoctorsdoctor.com)
  • Cytology
  • Cytology was positive for malignant cells, and these were initially suspected to be breast in origin. (hindawi.com)
  • enzyme
  • Recombinant TK1 cannot be activated and converted to a tetramer in this way, showing that the enzyme occurring in cells has been modified after synthesis. (wikipedia.org)
  • tumour
  • Immunohistochemistry shows strong cytoplasmic staining in tumour cells for pancytokeratin AE1/AE3, cytokeratins CAM5.2 and CK7 and for carcinoembryonic antigen (CEA) and BerEp4. (radiopaedia.org)
  • No staining for TTF-1, Napsin A or tyrosinase is seen in tumour cells. (radiopaedia.org)
  • Tumour extracts of CRC xenografts showed higher levels in the ratio of phosphocholine and glycerophosphocholine between poorly and well-differentiated cell lines. (bl.uk)
  • Colorectal
  • This study shows that micrometastases of colorectal carcinoma can be detected specifically with fluorescence imaging and SPECT/CT before they become visible with the naked eye," says Marlène C.H. Hekman of the Department of Radiology and Nuclear Medicine at Radboudumc, Nijmegen, The Netherlands. (eurekalert.org)
  • expression
  • The high expression makes it an attractive tumor-associated antigen for immunotherapeutic purposes ( 14 ). (aacrjournals.org)
  • Evidence of over-expression of HOXA11-AS as a causative factor of cell proliferation is seen when proliferation is blocked, once the lncRNA expression is knocked-down, or removed. (wikipedia.org)
  • patients
  • Although CEA is a self-antigen with a tendency to be immunologically tolerant, a HLA-A2.1-restricted CTL epitope peptide of CEA, CAP-1 (CEA 605-613 , YLSGANLNL), is a target for T cell lines derived from HLA-A2.1-positive patients with CEA-expressing malignancies ( 14 , 21 ). (aacrjournals.org)
  • The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and medical organization dedicated to raising public awareness about nuclear medicine and molecular imaging, a vital element of today's medical practice that adds an additional dimension to diagnosis, changing the way common and devastating diseases are understood and treated and helping provide patients with the best health care possible. (eurekalert.org)