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  • mRNA
  • Mutations at the complex interface impair mRNA deadenylation in mammalian cell extracts, suggesting that the GW182-PABC interaction contributes to microRNA-mediated gene silencing. (genes2cognition.org)
  • hypoxia
  • Recently, great effort has been invested toward elucidating the interplay between hypoxia-induced autophagy and cancer cell metabolism. (frontiersin.org)
  • To cope with oxygen deprivation, cells respond by adjusting their metabolic and bioenergetic demands through a number of oxygen-sensing pathways including the hypoxia-inducible factors (HIFs) family of transcription factors -dependent and -independent responses. (frontiersin.org)
  • substrate
  • We could show that in such cells, a sustained rearward cortical flow is sufficient to drive persistent cell motion in confinement, even in the absence of specific substrate adhesions. (newton.ac.uk)
  • Durotaxis, the phenomena where cells migrate up a gradient in substrate stiffness, remains poorly understood. (springer.com)
  • We develop a stochastic model where the cell moves by updating the position of its adhesion sites at random times, and the rate of updates is determined by the local stiffness of the substrate. (springer.com)
  • tumor cell invasion
  • In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
  • More notably, ARC deficiency also limited tumor cell invasion and the number of circulating cancer cells, markedly reducing the number of lung metastases. (aacrjournals.org)
  • invasion
  • CrkI and CrkII function as key signaling integrators for migration and invasion of cancer cells. (semanticscholar.org)
  • The hallmark of gliomas is local invasion of single tumor cells to adjacent and distant brain structures. (aacrjournals.org)
  • We confirmed these results in a humanized orthotopic model based on MDA-MB-231-derived LM2 metastatic breast cancer cells, in which RNAi-mediated knockdown of ARC levels was shown to reduce tumor volume, local invasion, and lung metastases. (aacrjournals.org)
  • mesenchymal
  • PDGFRα and CD51 mark human Nestin⁺ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion. (yu.edu)
  • transfection
  • Using transfection studies to insert a defective FAK gene, the authors showed that such cells failed to respond to Arginine indicating that FAK is critical to Arginine's effect. (bmj.com)
  • polarization
  • For example, during cell migration, contractility gradients towards the back of the cell have been involved in promoting cell polarization and the forward movement of the cell body. (newton.ac.uk)
  • The first phase is the polarization phase during which the cell defines its front end. (springer.com)
  • Tubulin (Green) and alpha-mannosidase II (Red) were labeled to note cell polarization and Golgi orientation. (upstate.edu)
  • induces
  • Methods and Results- We demonstrate that caffeine in physiologically relevant concentrations (50 to 100 μmol/L) induces migration of human EPCs as well as mature ECs. (ahajournals.org)
  • role
  • ECs which were depleted of mitochondrial DNA did not migrate when challenged with caffeine, suggesting a potential role for mitochondria in caffeine-dependent migration. (ahajournals.org)