Cell migration adhesion collagen and laminin. Medical search. Frequent questions

Previous studies have implicated β1 integrins in cancer since they regulate cell adhesion and migration/invasion on tumor stroma proteins such as fibronectin laminin and collagen (33). (biotech-angels.com)
The AM basement membrane contains laminin, fibronectin, and collagen type IV and VII, similar to the basement membrane of conjunctival tissue, but more than corneal epithelium. (touchophthalmology.com)
Moreover, significant adjustments in the expression of genes encoding extracellular matrix proteins had been observed, including collagens kind I, VII and XIV, fibronectin and laminin. (interleukin-receptor.com)
No colocalisation of mast cells was found with fibronectin or vitronectin. (bmj.com)
To demonstrate differences in human lens epithelial cell adhesion to different intraocular lens biomaterials in vitro and to determine whether these differences can be influenced by coating the intraocular lens surface with commercially available fibronectin. (arvojournals.org)
Coating the lenses with fibronectin caused a significant increase in attachment of lens epithelial cells for all three lens types. (arvojournals.org)
Cell attachment was more prominent in the acrylic lenses, but the fibronectin coating negated differences in lens type and caused a significant increase in cell attachment across all groups. (arvojournals.org)
For example, tumor cell motility mediated by α3β1 integrin on its ligand, laminin-332 (laminin-5), can be 3-4 fold faster than motility mediated by other β1 integrins, such as the collagen receptor, α2β1, or the fibronectin receptor, α5β1. (uiowa.edu)
Whereas endothelial cells plated on fibronectin or fibrinogen activate NF-κB in response to flow, cells on collagen or laminin do not. (rupress.org)
Furthermore, altering the extracellular matrix to promote p38 activation in cells on fibronectin suppresses NF-κB activation, suggesting a novel therapeutic strategy for treating atherosclerosis. (rupress.org)

Explore our solutions for multiple applications - vaccines, monoclonal antibodies, recombinant proteins, cell or gene therapy. (vwr.com)
GO analysis shows that the differential abundant proteins are associated with cell junction and signal transducer activity from extracellular to intracellular. (nature.com)
Moreover, integrins, laminins, NF-κB and other regulative molecules were found as crucial proteins. (nature.com)
There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)
2013).iScience 24, 102183, March 19,OPEN ACCESSlliScienceArticleExtracellular matrix proteinsThe ECM consists of multimeric proteins and proteoglycans that participate in cellular migration and differentiation and function as a assistance method for endothelial cells and astrocytes, and it can be pivotal for improvement, function, and regulation of vasculature, tight junctions, neurons, and astrocytes through cellular signaling and adhesion (Henrich-Noack et al. (idhinhibitor.com)
Biochemically, the BM consists of four big ECM proteins: collagen type IV, laminin, nidogen, and perlecan (Figure S7). (idhinhibitor.com)
The ECM composed of hundred proteins is a dynamic network controlling the proliferation, adhesion, migration, polarity, differentiation, and apoptosis of the cells. (premiumbeautynews.com)
Fibrosis is characterised by an excessive production of extracellular matrix components, and cells in the tissue are constantly interacting with these extracellular matrix proteins. (bmj.com)
In order to gain insight in to the elements managing Bmp2 signalling in the VER, we've researched the mRNA appearance of Bmp2 signalling elements, alongside the proteins and mRNA appearance patterns of most known laminin stores, in the tail-bud from the mouse embryo. (bioshockinfinitereleasedate.com)
Cells secrete proteins and GAGs to form a scaffold of insoluble extracellular matrix. (cellgs.com)
The cell surface receptors that interpret these cues engage cytoplasmic partners to transduce signals, but recent work reveals that many receptors also interact laterally with cell surface proteins that can be critical for proper receptor function. (uiowa.edu)
Our earlier studies helped to establish that α3β1 integrin is distinguished from other β1 integrins, such as α2β1 and α5β1, by its ability to avidly engage in complexes with members of the tetraspanin family of cell surface adaptor proteins. (uiowa.edu)
Tetraspanins, so named because of their four transmembrane domains, are a large family of proteins known for their ability to assemble multi-protein cell surface complexes. (uiowa.edu)
Integrin α3β1 strongly interacts with one particular tetraspanin, CD151, which in turn links α3β1 into larger cell surface complexes that may contain other tetraspanins, Ig superfamily (IgSF) proteins, growth factor receptors, membrane-bound growth factors, and novel proteins (Figure 1). (uiowa.edu)
Epithelial cells adjacent to the area of the defect flatten, lose their hemidesmosome attachments, and migrate on transient focal contact zones that are formed between cytoplasmic actin filaments and extracellular matrix proteins. (medscape.com)
Other than water, the mesoglea is composed of several substances including fibrous proteins like collagen and heparan sulphate proteoglycans. (pearltrees.com)
An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)
The way in which where mTOR pathways immediate actin redesigning and cell motion are not realized but may involve a colocalization of S6K1 with actin tension fibers18 aswell as actin redesigning proteins such as for example Rac1. (researchtoactionforum.org)
These properties will act mediating the action of cell adhesion proteins, regulating cell behavior and causing tissue regeneration. (bvsalud.org)
To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
The laminin globular (G) domain can be found in one to several copies in various laminin family members, including a large number of extracellular proteins. (embl.de)
Laminin G-containing proteins appear to have a wide variety of roles in cell adhesion, signalling, migration, assembly and differentiation. (embl.de)
We are interested how extracellular matrix proteins instruct cells to differentiate, migrate, and proliferate, and how cells sense normal and pathologically altered extracellular matrix. (mcgill.ca)
Although the mechanisms mediating the effects of the extracellular matrix (ECM) on breast carcinoma development in vivo are largely unknown, contributing factors may be adhesion mediated signaling and mechanical signals imparted on mammary epithelial cells from surrounding type-I collagen-rich stroma, either directly or across basement membrane proteins. (biomedcentral.com)
A family of extracellular proteins that are related structurally to LAMININ. (bvsalud.org)

Results: Differentiation of cord blood-derived monocytes in presence of hLF induced a distinct transcriptional program defined by cell cycle arrest in the G2/M phase, induction of IL-4/IL-13-like signaling, altered extracellular matrix interaction, and enhanced propensity for cell-cell interaction. (bvsalud.org)
Its effect and effectiveness appear to be highly connected with the differentiation status of the cancerous cells, as Ang II appears to play a crucial role in the early and late stages of malignant transformation. (spandidos-publications.com)
2-5 The basement membrane provides a substrate that promotes epithelial cell adhesion, migration, and differentiation 5-7 and prevents epithelial cell apoptosis. (touchophthalmology.com)
This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
The composition of extracellular matrix (ECM) is tissue specific, however, its functions with respect to cellular adhesion, communication, and differentiation remain uniform irrespective of the change in composition. (biologywise.com)
Conclusions Laminin532 could connect to 6-including integrin to 638-94-8 immediate differentiation from the specialised VER cells from surface area ectoderm. (bioshockinfinitereleasedate.com)
2010). Integrins including the 3 and 6 subunits have already been referred to as receptors for laminin, regulating actions such as business from the cellar membrane and differentiation of many epithelial cell types (Sorokin et al. (bioshockinfinitereleasedate.com)
Integrins are important regulators of cellular differentiation, migration, maturation, and survival [ 1 - 3 ]. (oncotarget.com)
The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. (pearltrees.com)
In order to be effective and integrated to the receiving area, the bone graft is required to allow a strong cell adhesion, interacting with several molecules to induce migration, differentiation, and thus the mineralization of the new bone on the graft. (bvsalud.org)
Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)

It's mostly made up of laminin, type IV collagen, and entactin, and it also features growth factors and other constituents, such as proteoglycans. (corning.com)
2007). Furthermore to these well referred to BMP regulators, various other elements, like the extracellular matrix elements collagen IV, heparan sulphate proteoglycans and laminins, are also found to are likely involved in modulating BMP signalling (Belenkaya et al. (bioshockinfinitereleasedate.com)

According to subsequent experiments, we found that the YIGSR peptide strongly enhanced collagen type 1 synthesis without changing cell proliferation or cellular MMP-1 level. (peptide.com)
For several decades, neovascularization is believed to be accomplished by proliferation of mature endothelial cells residing in the local vessels through the process of angiogenesis [ 6 ]. (hindawi.com)
Loss of GPR56 does not affect cell proliferation, migration, or neurite outgrowth. (jneurosci.org)
Consistent with this hypothesis, developing granule cells from the rostral region of Gpr56 −/− cerebella at birth exhibit a specific defect in cell adhesion to extracellular matrix (ECM) molecules of the pial basement membrane (BM) but no defects in migration, proliferation, or process outgrowth. (jneurosci.org)
We examined the effects of statin drugs on in vitro proliferation, migration and invasion of melanoma cells. (biomedcentral.com)
The ability of lovastatin, mevastatin and simvastatin to inhibit the melanoma cell proliferation was examined using cytotoxicity and apoptosis assays. (biomedcentral.com)
The concentrations required to inhibit proliferation of melanoma cells (0.8-2.1 μM) have previously been achieved in a phase I clinical trial of lovastatin in patients with solid tumours, (45 mg/kg/day resulted in peak plasma concentrations of approximately 3.9 μM). (biomedcentral.com)
The ECM a researcher chooses has a significant effect on cancer cell proliferation, initiation, invasion, and metastasis, and it alters how the tumor model responds to drug therapy. (corning.com)
We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. (spandidos-publications.com)
Our study revealed that Ang II influences EC cells in terms of cancer-related processes, and is responsible for increased proliferation, reduction in apoptosis, increased mobility and modulation of adhesion potential. (spandidos-publications.com)
Therefore, various biologically active peptides such as angiotensin, affecting cell proliferation, have become a new area of study in endometrial cancer research. (spandidos-publications.com)
Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)
4,19-21 The immunosuppressive ability of AM to inhibit a mixed lymphocyte reaction appears to be partly mediated by a soluble factor, resulting in decreased alloreactive T-cell proliferation and Th1 and Th2 cytokine production. (touchophthalmology.com)
This matrix lends structural as well as biochemical support to the cells surrounded by it, and forms a foundation for their growth and proliferation. (biologywise.com)
It consists of a variety of growth and differentiating factors that regulate and influence development, migration, proliferation, shape, and metabolic functions of the cells. (biologywise.com)
Deposition of collagen and proliferation of smooth muscle cells are the response to chronic inflammation and injury of the submucosa leading to fibrosis and thickening of the submucosa and the smooth muscle layers of the bowel wall. (bmj.com)
There is a host of other cellular processes which ECM fragments modulate including cell adhesion, proliferation, migration and apoptosis. (cellgs.com)
A sufficient supply of progenitor stem cells to facilitate epithelial cell proliferation is important for the cornea. (medscape.com)
The present study results indicated that compared with the same number of 2D-cultured cells, microtissue could secrete more nerve regeneration related cytokines to promote SCs proliferation and axons growth. (biomedcentral.com)

Indeed, granule cells from the rostral region of perinatal Gpr56 −/− cerebella show loss of adhesion to extracellular matrix molecules of the pial basement membrane. (jneurosci.org)
These studies establish a novel role for GPR56 in the adhesion of developing neurons to basal lamina molecules and suggest that this adhesion is critical for maintenance of the pia and proper cerebellar morphogenesis. (jneurosci.org)
Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
It not only functions as a physical scaffolding, but also provides a channel for the migration and communication of cells via the use of signaling molecules. (biologywise.com)
The cells embedded within it interact with the matrix as well as with other cells due to the presence of specialized matrix receptor molecules. (biologywise.com)
These molecules interact with the matrix as well as the internal processes of the cell, thereby, bringing about cellular exchange of signals. (biologywise.com)
Otiz-Urda and colleagues (7) showed the development of human being epidermal squamous cell carcinomas required the interaction between the two extracellular matrix molecules laminin 332 (LM332) and type VII collagen and recent studies show that this interaction is definitely mediated by signaling through integrin mediated adhesions. (monossabios.com)
Integrin mRNA expression is elevated in TGF B taken care of cells To get a metastases linked mRNA signature distinct to TGF B handled H157 NSCLC cells, we utilized the SABiosciences RT2 Profiler PCR Array that measures the expression of 94 genes relevant to adhesion molecules, proteases and extracellular matrix elements. (interleukin-receptor.com)
Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)
He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
At this stage, we looked in to the Leishmania list expression of genes of the CLDN household and ESAM that codes for the endothelial cell-specific adhesion molecule (ESAM), a transmembrane junction protein using a comparable structure to junctional adhesion molecules (Stamatovic et al. (idhinhibitor.com)
This "renowned" matrix plays one of the essential roles of the physical and biomechanical properties of the dermis with this intricate network of extracellular macromolecules providing cells structural, bioactive molecules and biochemical support. (premiumbeautynews.com)
As well as providing support and anchoring points for cells, and presenting non-matrix molecules, such as cytokines, to cells, the ECM itself presents a range of bioactive sites which interact with cell surface receptors. (cellgs.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Significant reductions in the phosphorylation of signaling molecules focal adhesion kinase, extracellular signal-regulated kinases 1 and 2, and v-Akt murine thymoma viral oncogene were observed in male MIPβ1KO islets when compared to controls. (oncotarget.com)
Platelets contain a number of integrins and cell adhesion molecules on their surface which bind to both leukocytes and endothelial cells (green). (comprehensivephysiology.com)
These cell adhesion molecules (CAM) will mediate the contact between two cells or between cells and the extracellular matrix, an essential process to the success of the implant. (bvsalud.org)
This paper is a systematic review of the literature on the mechanisms of cell adhesion to bone grafts associated to nanotechnology, describing the importance and the role of those molecules in the adhesion and thus in tissue regeneration. (bvsalud.org)
The main reported mechanisms involve cell adhesion molecules (CAMs) and extracellular matrix components. (bvsalud.org)
Several molecules are involved in the process of cell adhesion to bone grafts, highlighting the role of integrins, the focal adhesion mechanism, the influence of the collagen matrix, and the activity of alkaline phosphatase in bone matrix formation. (bvsalud.org)
Tissue engineering is a strategy very used to obtain functional repairing through the development of biological substitutes that can restore, keep or substitute damaged tissues or organs 31 , through the combination of scaffolds biocompatible with live cells and/or bioactive molecules 19 . (bvsalud.org)
Some of these molecules are glycoproteins expressed on the cell surface, socalled cell adhesion molecules (CAM), which mediate either the contact between two cells or the contact among cells and the extracellular matrix, being therefore of fundamental importance for adhesion 3 . (bvsalud.org)

Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. (biotech-angels.com)
in vivo yet does not influence primary tumor growth or activation of other integrins on these cells. (biotech-angels.com)
The latent website of AG-1478 enzyme inhibitor TGF1 has an v integrin binding site and studies have suggested that v integrins sequester latent TGF1 to the cell surface and control its activation locally (11). (monossabios.com)
B3 integrin is required to mediate the TGF B driven increases in cell transmigration across LECs Based to the considerable induction of integrin expression observed in our experimental ailments, we investigated the part of integrins in NSCLC adhesion to LECs. (interleukin-receptor.com)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
Cellular replies to laminin are established partly by several transmembrane receptors referred to as integrins (Miranti and Brugge, 2002). (bioshockinfinitereleasedate.com)
Integrins mediate cell adhesion and migration during development, in homeostasis, and in a variety of pathological settings, including tumor cell metastasis. (uiowa.edu)
We hypothesize that the diversity in the functions of different β1 integrins may derive in part from their differing patterns of lateral cell surface interactions. (uiowa.edu)
Another form of integrin functional diversity is the ability of individual integrins to mediate different responses in different cell types. (uiowa.edu)

They are known to be involved in certain cell processes, such as cell adhesion, cell growth, receptor binding, cell migration, and interaction with other extracellular matrix constituents. (wikipedia.org)
The laminin tyrosine-isoleucine-glycine-serine-arginine (YIGSR) peptide, corresponding to the 929-933 sequence of the Î²1 chain, is known to be a functional motif with effects on the inhibition of tumor metastasis, the regulation of sensory axonal response and the inhibition of angiogenesis through high affinity to the 67 kDa laminin receptor. (peptide.com)
KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
These findings demonstrate crosstalk between a tyrosine kinase receptor and an integrin involved in carcinoma cell invasion and metastasis and may explain in part how inhibitors of EGFR impact malignant disease. (biotech-angels.com)
Src activation downstream of EGFR is required for αvβ5-mediated carcinoma cell invasion and metastasis EGF receptor ligation and Src activation have been linked to the growth and malignant properties of many tumors (2 4 To assess whether HIF-C2 EGF-mediated migration was Src-dependent FG cells had been treated using a Src kinase inhibitor (SKI-606) ahead of EGF excitement. (biotech-angels.com)
The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
Over 40 matrikines have been identified, the most famous of which is endostatin, a 21 kDa fragment of collagen XVIII which inhibits vasculogenesis by binding to vascular endothelial growth factor receptor (VEGFR). (cellgs.com)

The cryopreserved AM contains epithelial cells and is disinfected with antimicrobial agents, attached to nitrocellulose paper with the basement membrane facing upward, stored in a deep freeze at -80°C, and thawed for five to 10 minutes before use. (touchophthalmology.com)
The basement membrane is also important for epithelial migration, and abnormalities in basement membrane structure, whether due to trauma (eg, recurrent erosion syndrome) or dystrophy (eg, basement membrane dystrophy), can lead to persistence of corneal epithelial defects and stromal ulceration. (medscape.com)
They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. (pearltrees.com)
The ductal system is coated by a chain of luminal epithelial cells (LECs) situated on a layer of myoepithelial cells (MECs) and encompassed by a distinguished basement membrane. (biomedcentral.com)
Two major cell types cooperate to build up the ductal units: inner polarized luminal epithelial cells (LECs) embraced by a layer of myoepithelial cells (MECs), both cell types are rimmed by a cohesive basement membrane (BM) [ 2 ]. (biomedcentral.com)

12-14 AM has also been shown to induce apoptosis of inflammatory cells. (touchophthalmology.com)
and cell cycle and apoptosis [ 3 , 4 ]. (encyclopedia.pub)

Previous studies demonstrated that MSCs could ameliorate the pathology associated with ischemic heart disease, ischemic stroke, and peripheral vascular disease by releasing several critical factors that increase cell survival, provide an appropriate microenvironment for repairing damaged tissue, and induce neovascularization [ 3 - 5 ]. (hindawi.com)
Similarly, we discovered the upregulation of VCAM1 that codes for the vascular cell adhesion molecule-1 protein, which mediates endothelial cell adhesion and VWF that codes for the von Willebrand aspect, a glycoprotein that could possibly be involved in brain homeostasis (Table S6) (Suidan et al. (idhinhibitor.com)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
NO is reactive oxygen radical that is produced in testicular vascular endothelial cells and leydig cells, and by affecting the hypothalamicpituitarygonadal axis causes a reduction in testosterone production and inhibits steroidogenesis [ 5 , 6 ]. (biomedres.info)

ESAM was also expressed at a decrease level in 3cell spheroids than in endothelial cell 2D monocultures (Figures 6A and 6F) since endothelial cells of mesoderm origin selectively encode the immunoglobulin loved ones adhesion molecule ESAM, which mediates GLUT1 Storage & Stability cell-cell adhesion via homophilic molecular interactions (Hirata et al. (idhinhibitor.com)
Major cell adhesion molecule interactions include (platelet‐leukocyte) P‐selectin‐PSGL‐1 and GP1bα‐Mac‐1. (comprehensivephysiology.com)
CD86,along with CD80/B7-1.is an important accessory molecule in T cell costimulation via it's interaciton with CD28 and CD152/CTLA4.Since CD86 has rapid kinetics of induction.it is believed to be the major CD28 ligand expressed early in the immune response.it is also found on malignant Hodgkin and Reed Sternberg(HRS) cells in Hodgkin's disease. (researchtoactionforum.org)

The present study aimed to investigate the effect of factors released from placental-derived MSCs (PL-MSCs) on EPC migration, which is a critical step of vasculogenesis, using an in vitro migration assay. (hindawi.com)
In DNA microarray results, compared to control, CaG treated mouse group showed upregulation of 192 genes including collagen,typeI,alpha1 (Col1a1), consistent with the highly increased in vitro extracellular matrix (ECM) adhesion on collagen 1 and up-regulation of heparanase (Hpse). (biomedcentral.com)
We have demonstrated previously that the loss of sdc-1 effects dermal and corneal wound healing in vivo and alters migration and integrin functions of epidermal keratinocytes (3) and dermal fibroblasts (4) in vitro. (monossabios.com)
A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
There was a significant difference in the degree of lens epithelial cell attachment to the various types of intraocular lenses in vitro. (arvojournals.org)
The role of β1 integrin in maintaining optimal islet function has previously been identified in vitro using cell lines and isolated islets. (oncotarget.com)
Subsequent in vitro and in vivo studies have demonstrated the initial steps of cancer cell invasion and dissemination by disrupting the integrity of the myoepithelial belt that encircles the LECs [ 7 , 8 , 9 , 10 , 11 ]. (biomedcentral.com)
Methodologically, the lab employs a wide spectrum of techniques ranging from in vitro biochemical and biophysical assays, to cell biology methods with primary cells and transformed cell lines, to light and electron microscopic techniques, to in vivo studies with genetically modified mouse models. (mcgill.ca)

The expression of this gene was maximum in 3D endothelial cell monocultures since the number of endothelial cells is greater than that in 3-cell spheroids. (idhinhibitor.com)
These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
This disease is a defect in fucose metabolism (lack of fucosylation of the carbohydrate selectin ligands) that results in failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s) expressed on leukocytes and endothelial cells. (medscape.com)
Platelets also adhere to endothelial cells and help capture flowing leukocytes from the circulation. (comprehensivephysiology.com)

2. The laminins forms networks that remain in close association with cells through interactions with cell surface receptors. (premiumbeautynews.com)
Thus, a more sophisticated understanding of cell migration will require a "cell surface interaction map" describing the physical and functional connections between receptors and their cell surface partners. (uiowa.edu)
Mouse monoclonal to CD86.CD86 also known as B7-2,is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors.It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. (researchtoactionforum.org)

To time, five distinct stores, three stores and three stores have been referred to, and their different combinations define the various laminin isoforms (Miner et al. (bioshockinfinitereleasedate.com)

Important biological events associated with plasma membranes, such as signal transduction, cell adhesion, and protein trafficking, are mediated through the membrane microdomains. (mdpi.com)
By using protein fractionation and mass spectrometry analysis, we identified several novel candidates for EPC migration enhancing factor in PL-MSCs secretome that could be used to enhance neovascularization in the injured/ischemic tissues. (hindawi.com)
Moreover, the candidate EPC migration inducing factors presented in PL-MSCs secretome were identified using protein fractionation and mass spectrometry analysis. (hindawi.com)
Collagen is the most abundant fibrous protein found in mammals' ECMs, and it plays a critical role in tumor growth and metastasis because it promotes cell adhesion and migration. (corning.com)
Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
neuroblastoma organoids (tumour fragments of ~30-60 cells) were obtained from patient-derived xenografts (models of cancer where patient-derived neuroblastoma cells are implanted into and a mouse and allowed to develop into a tumour) and embedded in 3D Matrigel (a gelatinous protein mixture containing laminin, collagen, nidogen, heparan sulphate proteoglycan, and entactin) or collagen. (nationalchildrensresearchcentre.ie)
2016). Three-cell spheroids over expressed CLDN5 that is by far the predominant CLDN within the endothelium that codes for the integral membrane tight junction protein CLDN5 and can be a gatekeeper of neurological functions (Figures 6A and 6F) (Gunzel and Yu, 2013). (idhinhibitor.com)
2001). Other genes upregulated in 3-cell spheroids with respect to endothelial cell 2D and 3D monocultures were GJA1 that codes for the gap junction alpha-1 protein (GJA1) also referred to as connexin-43 (Table S6) (Zhao et al. (idhinhibitor.com)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
MIPβ1KO islets displayed a significant increase in protein levels of the apoptotic marker cleaved-Poly (ADP-ribose) polymerase and a reduction of the cell cycle marker cyclin D1. (oncotarget.com)
Vinculin, a plasma protein, links fibers to talin, which is a cell membrane protein. (medscape.com)
AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. (molvis.org)
Western blot analysis and in situ hybridization confirmed the presence of AND-34 RNA and protein in lens epithelial cells, particularly at the lens equator. (molvis.org)
Congratulations to Kristen Segars, an MD/PhD candidate in Dr. Trinkaus-Randall's lab, for her receipt of an F30 grant for her work, "Delayed wound healing in diabetic corneal epithelia: reduction in protein response after injury and uncoordinated cell-cell communication. (bu.edu)
Using a new method for construction and database searches of sequence consensus strings, we have identified a new superfamily of protein modules comprising laminin G, thrombospondin N and the pentraxin families. (embl.de)

The mesohyl includes a noncellular colloidal mesoglea with embedded collagen fibers, spicules and various cells, being as such a type of mesenchyme. (pearltrees.com)

To verify a job for endogenous Src in EGF-induced migration FG cells had been transduced expressing C-terminal Src kinase (CSK) an inactivator of Src family members kinases (34). (biotech-angels.com)
Needlessly to say appearance of CSK (however not kinase-dead CSK) suppressed EGF-induced Src activation (Fig. 2B) and cell migration on. (biotech-angels.com)
Publicity to TGF B induced the phosphorylation of the focal adhesion kinase in H157 cells, a kinase that mediates integrin activation in response to TGF B remedy. (interleukin-receptor.com)
β1 integrin is the major β integrin subunit in pancreatic beta-cells and forms heterodimers with 12 α integrin subunits, which interact with components of the extracellular matrix (ECM) to control intracellular signaling via the focal adhesion kinase (FAK) and extracellular signal related kinase 1 and 2 (ERK1/2) pathways [ 4 ]. (oncotarget.com)

Laminins are glycoproteins that are involved in the organization of ECM. (biomedres.info)

Sdc-1 null keratinocytes are more adhesive and less migratory as they rely primarily on 64 to mediate their migration. (monossabios.com)
The integrin family members comprises 24 , heterodimeric people that mediate the connection of cells towards the extracellular matrix (Barczyk et al. (bioshockinfinitereleasedate.com)
Currently, a major focus in the lab is determining (i) the extent to which assembly into tetraspanin complexes can help to explain α3β1 integrin's ability to mediate unusually rapid tumor cell migration, and (ii) the implications of tetraspanin association for the role of α3β1 in metastatic tumor cell spread. (uiowa.edu)

These results demonstrate the loss of AND-34 dysregulates focal adhesion complex signaling in lens epithelial cells and suggest that AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens. (molvis.org)

Miner, 2008) but, due to the intracellular set up from the laminin heterotrimer ahead of its secretion, co-expression of , and string mRNAs in a specific cell type can be obligatory for creation of each particular laminin isoform. (bioshockinfinitereleasedate.com)

The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)
A) EM image of an inflamed mouse cremaster venule, demonstrating platelet‐neutrophil‐endothelial cell interaction. (comprehensivephysiology.com)
One important step to elucidating these signaling interactions is to determine the organization of the collagenous stroma surrounding both normal mammary glands and tumors within intact tissue so as to better understand the cell-matrix interaction and how matrix organization, density, and composition affect tumor formation and progression. (biomedcentral.com)

Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts. (peptide.com)
Fig. 1 (A) EGF induces avβ5-mediated Rap1 activation and cell metastasis Fig. 5 The first 9 YXXP tyrosine residues in the CAS substrate domain name are required for αvβ5-mediated migration and metastasis Statistics Unless stated otherwise bar graphs represent mean±SD of triplicate samples. (biotech-angels.com)

The dermal ECM is synthesized from fibroblasts and is primarily compromised of fibrillar collagen and elastic fibers, which support the mechanical strength and resiliency of skin, respectively. (peptide.com)
Extracellular matrix is the extracellular, complex mixture of various biomolecules and fibers secreted by cells in the tissues of multicellular organisms. (biologywise.com)
Contraction of actin fibers pulls the cell body forward. (medscape.com)
Local alterations in collagen density were clearly seen, allowing us to obtain three-dimensional information regarding the organization of the mammary stroma, such as radiating collagen fibers that could not have been obtained using classical histological techniques. (biomedcentral.com)
In particular, local cell invasion was found predominantly to be oriented along certain aligned collagen fibers, suggesting that radial alignment of collagen fibers relative to tumors facilitates invasion. (biomedcentral.com)
Consistent with this observation, primary tumor explants cultured in a randomly organized collagen matrix realigned the collagen fibers, allowing individual tumor cells to migrate out along radially aligned fibers. (biomedcentral.com)
The presentation of these tumor-associated collagen signatures allowed us to identify pre-palpable tumors and see cells at the tumor-stromal boundary invading into the stroma along radially aligned collagen fibers. (biomedcentral.com)

With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
These studies have served to highlight the role of AND-34/BCAR3 and p130Cas in cell adhesion and migration signaling pathways. (molvis.org)

Glycosaminoglycan, CaG can strengthen ECM by increasing activity of TIMP-2 and adhesion activity on collagen known to inhibit changes of ECM, leading to tumor cell invasion and progression. (biomedcentral.com)

The team then used time lapse video-microscopy to study the behaviour of neuroblastoma cells in real time. (nationalchildrensresearchcentre.ie)

Additionally, MECs contributed effectively to maintaining the right luminal cells' polarization and further separating them from the adjacent stroma by making an integrated fence. (biomedcentral.com)
Indeed, disruption of the MECs layer was reported to facilitate the invasion of the cancer cells to the surrounding stroma. (biomedcentral.com)
Therefore, damaging the MECs layer resulted in the release of various factors (such as SDF1/CXCL12, CXCL14, MMP, and tenascin) [ 11 , 12 ] with a potential to modify the tumour microenvironment and facilitate the paracrine communication between the tumour epithelial cells and the enclosed stroma enhancing the tumour aggressiveness [ 11 , 13 ]. (biomedcentral.com)

Biological assays and gene expression analysis were performed on three cell lines: ISH, MFE-296 and MFE-280. (spandidos-publications.com)
Biological assays were performed on well-[Ishikawa (ISH)] moderately (MFE-296) and poorly (MFE-280) differentiated human adenocarcinoma cancer cell lines, representing the G1, G2 and G3 stage of EC. (spandidos-publications.com)
We also examined whether TGF B taken care of cells traversed LEC monolayers at higher intensity in Boyden chambers assays. (interleukin-receptor.com)
Cell damage was assessed using MTT assays, and the lactate dehydrogenase (LDH) release rate and flow cytometry were used to detect the accumulation of reactive oxygen species (ROS) and mitochondrial membrane potential respectively. (sdbonline.org)

Adminstration with these GAGs increased survival time and decreased melanoma sizes in mice, in accordance with their inhibitory effects on cell growth ratio of melanoma B16F10. (biomedcentral.com)
GAGs also exert anti-cancer effects by altering structures of various tumor cells through sulfated modifications, including chondroitin sulfate (CS) and dermatan sulfate (DS). (biomedcentral.com)

Effects on cell migration and invasion were assessed using transwell invasion and migration chambers. (biomedcentral.com)
Lovastatin, mevastatin and simvastatin inhibited the growth, cell migration and invasion of HT144, M14 and SK-MEL-28 melanoma cells. (biomedcentral.com)
However, higher doses of statins may have a role to play in adjuvant therapy by inhibiting growth and invasion of melanoma cells. (biomedcentral.com)
Via direct actions on cancer cells and indirect actions on the tumor microenvironment, radiation has the potential to enhance epithelial-to-mesenchymal transition, invasion, migration, angiogenesis and metastasis. (biomedcentral.com)
Malignant tumors consist of cancer cells and tumor-associated host cells, both participating in invasion and distant metastasis. (biomedcentral.com)
Such treatment was associated with upregulation of invasion- and inflammation-promoting soluble factors, such as matrix metalloproteinase 2 (MMP2), its activator MMP14, tissue inhibitors of matrix metalloproteinase 2 (TIMP2), chemokine ligand 2 (CCL2), and urokinase-type plasminogen activator (uPA), the latter two being linked to the recruitment of the monocytic cells. (biomedcentral.com)
NCRC supported researchers at the Royal College of Surgeons in Ireland and colleagues at Johns Hopkins University, Texas Tech University, and Monash University have developed a 3D experimental model of neuroblastoma invasion and shown that the composition of the extracellular matrix influences the growth, viability, and local invasion of patient-derived neuroblastoma cells. (nationalchildrensresearchcentre.ie)
The composition of the ECM influenced the growth, migration, viability, and local invasion of the neuroblastoma organoids. (nationalchildrensresearchcentre.ie)
Cell invasion was influenced by the addition of growth factors or the repression of prognostic biomarkers (MYCN gene) showing that the model is suitable for gene knockdowns/induction studies or to test the efficacy of anti-cancer agents. (nationalchildrensresearchcentre.ie)
For example, integrin α3β1 is implicated in promoting the growth and invasion of some tumor cell types, but in acting as a suppressor in the progression of other tumor types. (uiowa.edu)
Cell invasion is a crucial step of tumor metastasis , finding new regulators of which offers potential drug targets for cancer therapy. (sdbonline.org)
This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)
dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)
Cross-linked fibrin is deposited in tissues surrounding wounds, inflammatory sites, or tumors and serves not only as a supporting substratum for trafficking cells, but also as a structural barrier to invasion. (silverchair.com)
While the plasminogen activator-plasminogen axis provides cells with a powerful fibrinolytic system, plasminogen-deleted animals use alternate proteolytic processes that allow fibrin invasion to proceed normally. (silverchair.com)

MCTS mimic many of the features that tumors exhibit in the human body, including extracellular matrix (ECM) deposition between cells, gradients in nutrient concentration, and strong cell-cell junctions. (corning.com)

However, it has widely been demonstrated that tumor cells negatively manage immune attack by activating several immune-suppressive mechanisms. (encyclopedia.pub)
This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)
An augmented understanding of the common mechanisms of pathology among larger numbers of B-cell Non-Hodgkin's Lymphoma (BCNHL) patients is sorely needed. (fortunepublish.com)
This analysis supports past findings and validates existing knowledge while providing novel insights into the inner workings and mechanisms of transformed B-cell lymphomas that could give rise to improved diagnostics and/or therapeutics. (fortunepublish.com)
By mechanisms that we are still unraveling, α3β1 integrin appears to generate signaling that helps to promote stable cell-cell junctions among tumor cells, and this junction-stabilizing function may oppose α3β1's pro-migratory functions. (uiowa.edu)
Accurate identification of these mechanisms of cell adhesion is essential for further advancement in tissue engineering, such as the production of biological bone substitutes that achieve a better clinical outcome. (bvsalud.org)
1992]. Molecular mechanisms by which DCN interacts with TSP and inhibits cell adhesion to TSP are unknown. (embl.de)
The Reinhardt laboratory is interested in components and mechanisms involved in the biogenesis, function and pathological aspects of the extracellular matrix and its interactions with cells. (mcgill.ca)

Syndecan-1 (sdc-1) is a cell surface proteoglycan that mediates the connection of cells with their matrix, influencing attachment, migration and response to growth factors. (monossabios.com)

The main outcome measure was the mean number of lens epithelial cells attached to each lens type after 24 hours of incubation. (arvojournals.org)
Some reports suggest that the design of the IOL is important, 10 12 13 others state that the adhesive properties of the lens material may be relevant, 6 7 10 as soft acrylic IOLs show greater lens epithelial cell (LEC) adhesion than do PMMA and silicone lenses. (arvojournals.org)
While Akt Ser 473 phosphorylation was readily detectable in AND-34 +/+ lens epithelial cells, it was markedly reduced in the AND-34 −/− lens epithelium. (molvis.org)

Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins. (embl.de)
Decorin inhibits cell attachment to thrombospondin-1 by binding to a KKTR-dependent cell adhesive site present within the N-terminal domain of thrombospondin-1. (embl.de)
Skin decorin (DCN) is an antiadhesive dermatan sulfate-rich proteoglycan that interacts with thrombospondin-1 (TSP) and inhibits fibroblast adhesion to TSP [Winnemoller et al. (embl.de)

The goal of specific molecular targets in cancer therapy is to create a "magic bullet" that selectively kills cancer cells. (medscape.com)
As our understanding of the molecular biology of HNSCC continues to develop, we can target the specific components of cancer cells that are not found in normal cells. (medscape.com)
Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)
To determine molecular mechanism involved in the anti-cancer effect of dung beetle GAG, its origin N-glycan under 3KD Dalton was assayed for melanoma cell cytotoxicity. (biomedcentral.com)
Hence, altering expression of CS and heparan sulfate (HS) on surface of tumor cells is a potential molecular strategy to prevent malignant transformation and tumor metastasis [ 2 ]. (biomedcentral.com)
Indirect measurements, analyze the assessment of parameters that are linked to the biomechanical properties of the skin and give information on: Collagen, Face analysis and volume, molecular composition, proteomics and metagenomics, dermis size and shape, Skin aspect and structure. (premiumbeautynews.com)
In this review, we provided an overview of the myoepithelial cells' histogenesis, molecular and biological markers, and physiological commitments. (biomedcentral.com)

This YIGSR peptide-mediated collagen type 1 synthesis was modulated by FAK inhibitor and MEK inhibitor. (peptide.com)
This study clearly reveals that YIGSR peptide plays a novel function on the collagen type 1 synthesis of dermal fibroblasts and also suggests that YIGSR is a strong candidate peptide for the treatment of skin aging and wrinkles. (peptide.com)
We studied the secretome profile of gestational tissue-derived MSCs and their effects on functions of endothelial progenitor cells (EPCs), another angiogenic cell type that plays an important role during the neovascularization. (hindawi.com)
Collagen type I hydrogels have been used to grow MCTS from osteosarcomas, breast cancer cells, human colorectal cancer cells, prostate cancer cell lines, and primary cancer cells from colorectal cancer patients, according to the Science Advances study. (corning.com)
network-forming non fibrillar collagens (type IV), that composed a non-fibril network. (premiumbeautynews.com)
fibril-associated collagens (types IX, XII), and others (type VI). (premiumbeautynews.com)
Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)
This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
This 10-month-old patient with severe leukocyte adhesion deficiency type I (LAD I) developed a cervical adenitis caused by Klebsiella pneumoniae. (medscape.com)
Another reported type of leukocyte adhesion deficiency involves dysfunction in platelet aggregation in addition to a defect in leukocyte adhesion. (medscape.com)
Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)

mTOR inhibitors dramatically reduced collagen-induced platelet aggregation and promoted the destabilization of platelet aggregates formed under shear flow conditions. (researchtoactionforum.org)

but the role of GPR56 in neuronal migration in vivo remains unknown. (jneurosci.org)
The study's results confirmed previous findings that a treatment protocol of cisplatin and radiation was superior to radiation alone and confirmed the feasibility of using primary tumor cells for spheroid formation, which could yield MCTS that more closely mimic in vivo tumor behavior. (corning.com)
Since αvβ5 requires activation to promote cell migration we considered whether EGF and integrin αvβ5 could coordinately influence the spontaneous metastasis of FG HIF-C2 cells in vivo. (biotech-angels.com)
Imaging of the tumor-stromal interface in live tumor tissue ex vivo was performed with multiphoton laser-scanning microscopy (MPLSM) to generate multiphoton excitation (MPE) of endogenous fluorophores and second harmonic generation (SHG) to image stromal collagen. (biomedcentral.com)

Matrigel and collagen mimic the extracellular matrix (ECM) , the non-cellular component of tissue that provides a scaffold for cells to grow on and regulates a number of important physiological process such as cell adhesion, growth, and migration. (nationalchildrensresearchcentre.ie)
Current knowledge of cellular behavior is mainly acquired by studies concerning homogenous populations of cells cultured as monolayers. (intechopen.com)
This delay is required for preparatory cellular changes prior to rapid cell movement. (medscape.com)

Knockdown of Rap1b expression in FG cells selectively blocked EGF-induced migration on vitronectin (Fig. 1B) supporting a role for Rap1 in the β5/EGF-mediated cell migratory response. (biotech-angels.com)
SKI-606 suppressed EGF-induced Src phosphorylation in FG cells (Supplemental Fig. S2A) and obstructed EGF-mediated migration on vitronectin however HIF-C2 had no influence on EGF-independent migration on collagen (Fig. 2A). (biotech-angels.com)

This article reviews the role of platelets in inflammation and immune responses, and highlights their interactions with other immune cells, including examples of major functional consequences of these interactions. (comprehensivephysiology.com)
The dynamics of cell-extracellular matrix interactions in normal and pathological situations. (mcgill.ca)

TGF B remedy greater cell adherence to LEC monolayers and altered cell motility when measured by video microscopy. (interleukin-receptor.com)

Such biological functions depend on their lectinic properties (recognition of N-acetyllactosamine sequences displayed on the cell surface, in the extracellular matrix, or intracellular glycoconjugates) ( Table 1 ). (encyclopedia.pub)

For example, peptides from laminin are effective against E.coli and S aureus . (cellgs.com)

In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)
Basal and limbal stem cells contribute to mitosis. (medscape.com)

After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). (spandidos-publications.com)
This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)
In endothelial cell 2D monocultures, the expression of CLDN genes was generally reduced than that in both 3D systems except for CLDN1, CLDN11, and CLDN12 (Figures 6A and 6F). (idhinhibitor.com)

The extracellular matrix (ECM) acts as an adhesive that holds all the cells of a tissue in place. (biologywise.com)
Numerous cytokines and growth factors that are up-regulated in corneal cells further contribute to tissue inflammation. (medscape.com)
The IHC tests showed that the ECM of the mice testicular interstitial tissue showed reaction to anti-laminin-α5 antibody. (biomedres.info)
High concentration of sodium nitrate did not change the laminin α5 expression in the ECM of the testicular interstitial tissue. (biomedres.info)
Sodium nitrite causes the irritation of evolving male germ cells by disrupting hormonal balance and tissue anoxia, and by deforming the sperms, causes the reduction of their fertility. (biomedres.info)
A small percentage of AND-34 −/− mice show distinctive small white eye lesions resulting from the migration of ruptured cortical lens tissue into the anterior chamber. (molvis.org)
Tissue-engineered microtissue is an effective strategy for stem cell culture and therapy in nerve tissue engineering. (biomedcentral.com)
The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)
GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)

At the age of defect onset, GPR56 expression is restricted specifically to developing granule cells in the rostral cerebellum, suggesting that GPR56 regulates properties of these cells. (jneurosci.org)
cancer cell growth and spreading, it has also been proposed that GPR56 regulates cell adhesion, but this has remained untested in the nervous system. (jneurosci.org)
Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor dependence. (molvis.org)

The aim of this study was to investigate whether mast cells accumulate in these tissues and whether their localisation is associated with extracellular matrix components. (bmj.com)

Therapeutic potentials of mesenchymal stem cells (MSCs) depend largely on their ability to secrete cytokines or factors that modulate immune response, enhance cell survival, and induce neovascularization in the target tissues. (hindawi.com)

After the use of search strategies, 18 articles that describe processes of cell adhesion to bone grafts were selected. (bvsalud.org)

after transplantation to the recipient region, single cells are vulnerable to the interference of various factors, such as ischemia and inflammation, leading to cell loss or death [ 16 ]. (biomedcentral.com)

Anatomy43

Organisms9

Diseases8

Chemicals and Drugs121

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology1

Phenomena and Processes45

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science5

Fibronectin10

Proteins29

Differentiation11

Proteoglycans2

Proliferation19

Molecules22

Integrins9

Receptor7

Basement membrane5

Apoptosis2

Vascular4

Molecule3

Vitro8

Endothelial cells4

Receptors3

Various laminin1

Protein15

Embedded collagen fibers1

Kinase4

Glycoproteins1

Mediate3

Focal adhesion1

Secretion1

Interaction3

Induces2

Fibers7

Pathways2

Known to inhibit1

Time lapse video-microscopy1

Stroma3

Assays4

GAGs2

Invasion15

Deposition1

Mechanisms8

Mediates1

Lens epithelial3

Thrombospondin3

Molecular7

Type11

Platelet aggregation1

Vivo4

Cellular3

Vitronectin2

Interactions2

Video microscopy1

Intracellular1

Peptides1

Basal2

Genes3

Tissue9

Regulates3

Extracellular matrix components1

Cytokines1

Processes1

Inflammation1