Cell membrane adenosine triphosphatase activity. Medical search. Frequent questions

ATP is required by the actomyosin adenosine triphosphatase (ATPase) for contraction and relaxation of cardiomyocytes. (journalmc.org)
Additionally, membrane-bound ATPase utilizes ATP for depolarization and repolarization of cell membranes. (journalmc.org)
The effects of the elicitor and the suppressor on the ATPase activity in pea plasma membranes was examined. (elsevierpure.com)
The relationship between the inhibition of plasma membrane ATPase activity and the suppression of the active defense reaction that involves the production of pisatin in the pea plant is discussed. (elsevierpure.com)
the degradation of ubiquitinated substrates embedded in the membrane then requires their dislocation into the cytosol, a reaction mediated by a conserved ATPase named p97 in mammals or Cdc48 in Saccharomyces cerevisiae ( Christianson and Ye, 2014 ). (rupress.org)
During this process, the hexameric barrel-like ATPase p97/Cdc48, assisted by an array of cofactors, uses the energy from ATP hydrolysis to extract polypeptides from the membranes for targeting to the proteasome. (rupress.org)
Na+,K+-adenosine triphosphatase (NKA) is a P-type ion-motive ATPase and integral membrane protein that spans the cell membrane via a hydrophobic trans-membrane (TM) domain and is known to be associated with rafts [5-12]. (researchsquare.com)
The Na + ,K + -ATPase maintains the physiological gradients for Na + and K + ions and is, therefore, critical for the activity of ion channels and transporters involved neuronal excitability, neurotransmitter uptake or Ca 2+ signaling. (frontiersin.org)
We identify the vacuolar H + -adenosine triphosphatase (V-ATPase) complex as a crucial regulator of NuRD's asymmetric segregation. (elifesciences.org)
V-ATPase interacts with NuRD and is asymmetrically segregated into the surviving daughter cell. (elifesciences.org)
We suggest that asymmetric segregation of V-ATPase may cause distinct acidification levels in the two daughter cells, enabling asymmetric epigenetic inheritance that specifies their respective life-versus-death fates. (elifesciences.org)
revised 25 April 1979) Homogenates of Tritrichomonas foetus exhibited a Mg2+-dependent adenosine triphosphatase (ATPase) activity, with a pH optimum in Tris buffers of 8-2 to 8.3. (docksci.com)
The ATPase activity (or activities) in this aerotolerant anaerobe is different from the ATPases characteristic of mitochondria or of anaerobic bacteria. (docksci.com)
Since adenosine triphosphatases (ATPases) of different organelles and micro-organisms show characteristic properties, it was felt that a study of the ATPase activities present in a trichomonad could contribute to the elucidation of the biological nature of hydrogenosomes. (docksci.com)
The plasma membrane H + -ATPase plays a central role in all plant physiological processes. (edu.au)
Changes in the activity of the plasma membrane H + -ATPase through regulating the expression and phosphorylation of this enzyme are also involved in many plant responses to Al toxicity. (edu.au)
The plasma membrane H + -ATPase mediated HC influx may be associated with the maintenance of cytosolic pH and the plasma membrane gradients as well as Al-induced citrate efflux mediated by a HC-ATPase-coupled MATE co-transport system. (edu.au)
In particular, modulating the activity of plasma membrane H + -ATPase through application of its activators (e.g., magnesium or IAA) or using transgenics has effectively enhanced plant resistance to Al stress in several species. (edu.au)
In this review, we critically assess the available knowledge on the role of the plasma membrane H + -ATPase in plant responses to Al stress, incorporating physiological and molecular aspects. (edu.au)
Further experiments in primary hepatocytes demonstrated that Reptin maintains mTOR protein level through its ATPase activity. (nih.gov)
Major factors contributing to this poor K+ retention ability are (1) an intrinsically lower H+-ATPase activity in the root apex, (2) greater saltinduced membrane depolarization, and (3) a higher reactive oxygen species production under NaCl and a larger density of reactive oxygen species-activated cation currents in the apex. (uab.cat)
The protein has been determined to be biologically active in a microtubule-activated ATPase activity test. (cytoskeleton.com)
The microtubule-activated ATPase activity of the MKLP1 motor is not inhibited by this contaminant. (cytoskeleton.com)
MKLP1 ATPase activity was measured by monitoring real time free phosphate generation using the Kinesin ELIPA Assay Kit (cat. (cytoskeleton.com)
Under the conditions outlined below, the Vmax for MKLP1 microtubule-activated ATPase activity for this Lot was 1000 nmoles ATP generated per minute per mg of MP01 (Figure 2). (cytoskeleton.com)
Furthermore, vacuolar-type H+-ATPase (V-ATPase) and H+/Cl- exchange transporter 7 (CLC-7) were detected on the surface of AM-1 cells by plasma membrane biotinylation and immunofluorescence analysis. (elsevierpure.com)
Immunohistochemical analysis of clinical samples of ameloblastoma also showed plasma membrane-localized V-ATPase and CLC-7 in the epithelium of plexiform, follicular and basal cell types. (elsevierpure.com)
0.001) in the response to the endoplasmic reticulum Ca2+- adenosine triphosphatase (ATPase) inhibitor, thapsigargin, suggesting the Ca2+ release-activated Ca2+ current across the plasma membrane was enhanced. (ed.ac.uk)

1992). These oxygen free radicals can modify DNA, proteins and membrane lipids, leading to cellular degeneration (Olanow, 1992). (scialert.net)
Eukaryotic cells use the ubiquitin proteasome system to eliminate misfolded proteins from diverse subcellular compartments to maintain protein homeostasis. (rupress.org)
However, the degradation of proteins in lipid bilayer or membrane-encircled organelles requires additional steps because the membranes render these substrates, at least in part, inaccessible to the ubiquitin proteasome system. (rupress.org)
Quantitative assessment of the mutual interaction between functional trans-membrane proteins and the lateral molecular organization of membranes requires assays where the molecular composition of lipids and reconstituted proteins can be accurately controlled. (researchsquare.com)
Considering that the raft hypothesis, linking membrane function to lateral structure, is based on the assumption that functional proteins interacting differently with the rafts and the membrane matrix [1-4], it is of importance to have available methods to study this interaction in a simple setting using model systems that permit quantitative measurements of how lateral membrane organization and active proteins mutually influence each other. (researchsquare.com)
A minimal model system involves reconstitution of active proteins in multi-component membranes. (researchsquare.com)
The study of the function and regulation of NKA or similar TM-proteins by the membrane lipid composition and the physical state of model membranes has so far led to the successful development of a method of preparation of cell-size giant unilamellar vesicles (GUVs) containing reconstituted proteins based on electroformation of a single population of proteoliposomes. (researchsquare.com)
If the cell contains proteins, which cannot pass through the cell membrane and there is potassium chloride, which can pass through the cell membrane, the product of potassium and chloride concentrations in the cell will be equal to the product of potassium and chloride concentrations on the outside at equilibrium. (iupac.org)
Furthermore, there are the proteins in the cell, which also adds to the osmotic pressure. (iupac.org)
A systematic genetic analysis was performed to identify the inner membrane proteins essential for type IV pilus (T4P) expression in Pseudomonas aeruginosa. (mcmaster.ca)

Although salinity-induced transient net Na+ uptake was about 4-fold higher in the root apex compared with the mature zone, mature root cells accumulated more cytosolic and vacuolar Na+, suggesting that the higher sensitivity of apical cells to salt is not related to either enhanced Na+ exclusion or sequestration inside the root. (uab.cat)

Their major function is the provision of energy in terms of adenosine triphosphate (ATP) by the oxidative phosphorylation system (OXPHOS). (journalmc.org)
Adenosine triphosphate (ATP), in small amounts, is used rapidly at the onset of activity but is quickly depleted. (todaysveterinarypractice.com)

The present study was aimed to evaluate the oxidants, enzymatic and nonenzymatic antioxidants, glycoproteins and membrane adenosine triphosphatases (ATPases). (scialert.net)
Hence, the present study was designed to examine the effect of T. chebula on erythrocyte oxidation products level, antioxidant status, membrane ATPases and glycoproteins in aged rats compared with young rats. (scialert.net)
Here, we present data that PilC may coordinate the activity of cytoplasmic polymerization (PilB) and depolymerization (PilT) ATPases via their interactions with its two cytoplasmic domains. (mcmaster.ca)

It is concluded that neurohypophyseal peptides are capable of producing graded effects on adenyl cyclase both below and above the range of enzyme activity which evokes graded changes in membrane permeability. (silverchair.com)
In the following years it was shown that cell membrane permeability to sodium was a general phenomena. (iupac.org)
Targeting virulence factors is also of interest, offering high selectivity, as is targeting "physical" properties, such as membrane lipid bilayer permeability, as with daptomycin. (illinois.edu)
Plus, in some cases they will also affect membrane permeability, virulence and innate immunity. (illinois.edu)

J Cell Biol (2016) 213 (1): 7-9. (rupress.org)

Duration of muscle activity determines the primary fuel source used for contraction. (todaysveterinarypractice.com)
T-tubules and sarcoplasmic reticulum are responsible, respectively, for conduction of electrical signals from the cell surface and the intracellular storage and release of calcium required for contraction to occur. (medscape.com)

Energy production in mitochondria involves five oligomeric complexes which are embedded within the inner mitochondrial membrane. (journalmc.org)

Dislocation of polypeptides from the mitochondrial outer membrane by the p97/Cdc48-Ufd1-Npl4 adenosine triphosphatase complex is essential for mitochondria-associated degradation and Parkin-mediated mitophagy. (rupress.org)
A nerve impulse is a sharp movement of sodium and potassium ions across the outer membrane of a neuron using potential-dependent ion channels. (saveupdata.com)

Additionally, it was revealed that the most relevant genes are involved in biological processes related to signal transduction, positive regulation of transcription from RNA polymerase II promoters, chemical synaptic transmission, response to drugs, ion transmembrane transport, nervous system development, cell adhesion, and neuron migration. (biomedcentral.com)

Unexpectedly, loss or inhibition of Reptin induced an opposite effect on mTORC1 and mTORC2 signalling, with: (1) strong inhibition of hepatic mTORC1 activity, likely responsible for the reduction of hepatocytes cell size, for decreased de novo lipogenesis and cholesterol transcriptional programmes and (2) enhancement of mTORC2 activity associated with inhibition of the gluconeogenesis transcriptional programme and hepatic glucose production. (nih.gov)
Inhibition of hepatic Reptin expression or activity represents a new therapeutic perspective for metabolic syndrome. (nih.gov)
Arthorkinematic Inhibition: a reflexive decrease in muscle activity due to joint dyskinesis. (brookbushinstitute.com)
We hypothesize that isoprenoid biosynthesis enzymes, prenylsynthases and prenyltransferases, involved in cell wall and quinone biosynthesis, represent a new generation of targets whose inhibition will lead to new drug leads that synergize with existing antibiotics. (illinois.edu)

Plant and Cell Physiology , 31 (8), 1139-1146. (elsevierpure.com)

Decreased ATP levels may thus not only impair contractility but may also lower the mitochondrial membrane potential and thus impair impulse generation and conduction along the cardiac conduction system, manifesting as arrhythmias [ 6 ]. (journalmc.org)

Cytochrome-b plays a crucial role for the activity of the bc1 complex since it harbors two b-hemes and determines the shape of the two ubiquinone fixation sites. (journalmc.org)
Hence the results do not easily carry over to complex multi-component biological membranes. (researchsquare.com)
Here, we demonstrate that the nucleosome remodeling and deacetylase (NuRD) complex is asymmetrically segregated into the surviving daughter cell rather than the apoptotic one during ACDs in Caenorhabditis elegans . (elifesciences.org)

The nature of the effect was to reduce the characteristic modulation of basal activity caused by transported substrates, modulators and the potent inhibitor XR9576. (aston.ac.uk)

2000). The high polyunsaturated fatty acid content of the erythrocyte membrane and the continuous exposure to high concentrations of oxygen and iron in heamoglobin are factors that make erythrocytes very sensitive to oxidative injury (Bernabucci et al . (scialert.net)
Supplementation of ascorbic acid to the rats fed on 18% or 6% protein diet was found to reduce the TBARS production remarkably in packed erythrocytes while it further raised the TBARS production in erythrocyte membrane in response to chronic and acute heat exposure. (ijcrr.com)
Membrane cholesterol contents modify the protective power of flavonoids against oxidative stress in erythrocytes [21].The antioxidant power of flavonoids, in turn depend on the depletion or incorporation of cholesterol in the erythrocyte membrane [22]. (ijcrr.com)

A particularly major mark in this time was that he discovered Calmodulin molecules containing calcium ions deposited on the membrane of cancer cells named L-1210. (wikipedia.org)
His studies eventually led to the problems of transport of ions across cell membranes. (iupac.org)
As the cell membrane is permeable to water, the only way to establish the equilibrium is by adding some ions on the outside to compensate for the high osmotic pressure inside the cell, and that ion is sodium. (iupac.org)

0.01) in the resting cytosolic Ca2+ concentration of Monomac 6 cells. (ed.ac.uk)
These data suggest that ultrafine carbon black particles stimulated an increase in cytosolic Ca2+, possibly through the entry of extracellular Ca2+ via Ca2+ channels in the plasma membrane. (ed.ac.uk)

The TSH-receptor is the only G-protein-coupled receptor known able to activate all G protein families, an activity directly mimicked by fluoride. (poisonfluoride.com)
Increased TBARS productions were found when measured in packed erythrocytes and erythrocyte membranes in both the rats fed on 18% or 6% protein diet after acute and chronic heat exposure. (ijcrr.com)
Decreased GSH content and increased membrane total thiol (-SH) content of erythrocytes were observed in both 18% protein-fed and 6% protein-fed rats. (ijcrr.com)
Prior supplementation of ascorbic acid was found to restore partially the GSH content of erythrocyte and to potentiate the increase in membrane total thiol (-SH) content in both adequately protein-fed and protein-restricted groups of rats. (ijcrr.com)
The membrane lipid changes and the associated production of signalling metabolites clearly have a pivotal function to modify the heat stress response [27].In addition, dietary protein level is also known to have profound influence on antioxidant system and membrane composition and stability[28]. (ijcrr.com)
This simple model system has been studied using advanced optical microscopy techniques and flicker-noise analysis and it has been demonstrated that the intrinsic reaction-cycle time scale of NKA manifests itself in the lipid-protein interactions of non-equilibrium membranes and the membrane softens due to protein's activity [14]. (researchsquare.com)
Then, a survey is given about ATP1A2 mutations implicated in migraine cases as documented in the literature with focus on mutations that were described to completely destroy enzyme function, or lead to misfolded or mistargeted protein in particular model cell lines. (frontiersin.org)
we found that components of the inner membrane subcomplex consisting of PilMNOP were not essential for surface pilus expression, whereas the highly conserved inner membrane protein PilC was essential. (mcmaster.ca)

It is believed that it expands in the jaw bone through peritumoral activation of osteoclasts by receptor activator of nuclear factor kappa-B ligand (RANKL) released from the ameloblastoma, as in bone metastases of cancer cells. (elsevierpure.com)
The demineralization activity of AM-1 was only 1.7% of osteoclasts demineralization activity, and the growth rate was 20% of human normal skin keratinocytes and HSC-3 cells. (elsevierpure.com)

Epithelial type II cells from adult rat lungs were exposed to halothane concentrations of 1, 2, and 4% from 0.5-4 h. (asahq.org)
The decrease in sodium, potassium-adenosine triphosphatase activity was maximal for 30 min of exposure and reached 50, 42, and 56% for halothane concentrations of 1, 2, and 4%, respectively, and did not change for longer exposure times. (asahq.org)

Adenyl Cyclase - A membrane-bound enzyme that converts adenosine monophosphate to cyclic adenosine monophosphate (cAMP), an intracellular second messenger. (poisonfluoride.com)

We find that the method works only if cholesterol is added to the high melting lipids in the small unilamellar vesicles (SUVs) of different populations in order to bring the vesicle membrane into the fluid phase prior to electroswelling and not otherwise. (researchsquare.com)

Common channels for water and protons at apical and basolateral cell membranes of frog skin and urinary bladder epithelia. (silverchair.com)
We have combined electrophysiological, imaging, and biochemical techniques to reveal the physiological mechanisms conferring higher sensitivity of apical root cells to salinity in barley (Hordeum vulgare). (uab.cat)

Exposure of epithelial type II cells to halothane reduced the activity of sodium, potassium-adenosine triphosphatase, and amiloride-sensitive Na channels, whereas Na cotransporters were unchanged. (asahq.org)

Bovine granulosa cells from 3-7 mm follicles were cultured without anchorage in soft agar/methylcellulose solution for 14 days, with or without 50 ng/ml basic fibroblast growth factor. (shengsci.com)

In the 1870s it was shown that there is a difference in the concentration of sodium and potassium inside and outside the cell. (iupac.org)

Thus, granulosa cells in anchorage-independent cultures have a follicular cell morphology and secrete two distinct extracellular matrices, one similar to the follicular basal lamina. (shengsci.com)

They discovered that changes in blood pressure, or alterations in Angiotensin II, provoke rapid trafficking of renal sodium transporters between membrane domains, associated with phosphorylation and pool size regulation. (usc.edu)

T. chebula has been reported to exhibit a variety of biological activity, including anticancer (Saleem et al . (scialert.net)

NKA activity and density in the active GUVs are measured using standard biochemical methods [15-17]. (researchsquare.com)

Starting from here, he went deeply into the research field of cancer cell membrane. (wikipedia.org)
He has published dozens of articles for research on cancer cell membranes in English on the scientific subjected journals of Germany, Japan, and Poland. (wikipedia.org)

The activity was localized in a population of small cytoplasmic particles which also contained an acid phosphatase. (docksci.com)

Muscles allow dogs to perform activity, and muscle fibers are generally classified as type I (slow twitch) or type II (fast twitch). (todaysveterinarypractice.com)
Mature muscle cells are termed muscle fibers or myofibers and they are often simply referred to as fibers . (medscape.com)

Na enters the cells through amiloride-sensitive Na channels or Na cotransporters and is extruded by a Na pump. (asahq.org)
But in l939, it was shown that the muscle membrane was permeable to sodium, and it was suggested that there are pumps in the membrane that pump sodium out (i.e., the distribution of sodium is not an equilibrium distribution but a steady state distribution that requires energy). (iupac.org)
By then the existence of the ion pump in the cell membrane had been accepted, but it was not known what the nature of the pump was. (iupac.org)

[1,2] Recently, however, halothane was shown to inhibit Na/calcium (Ca) exchanger and Ca channels in heart cells [3] and to decrease ion transport in canine tracheal epithelium, an effect that may contribute to decreased mucous clearance in the perioperative period. (asahq.org)

Another is that stimulating the first responders-gamma delta T cells, neutrophils and macrophages, could be effective. (illinois.edu)

Ultrastructure of the nongranulated cells and morphology of the extracellular spaces in the pars distalis of adult and pouch-young tammar wallabies (Macropus eugenii). (shengsci.com)

However, the clinical features of ameloblastoma, including its growth rate and patterns of invasion, are quite different from those of bone metastasis of cancer cells, suggesting that different underlying mechanisms are involved. (elsevierpure.com)

In June, 1976, he returned to Poland, with Professor Kaviac studied of experimental cancer - malignant cell line nodes in mice. (wikipedia.org)

Downregulated number of p53 and Ki67 positive cells were observed in the tissues after Er: YAG laser assisted PDT. (bvsalud.org)
In addition, increased CD8+ positive cells infiltrated around the tissues and increased natural killer (NK) cells level were detected in the peripheral blood. (bvsalud.org)

2002). However, during aging an oxidant challenge exceeds the capacity of the cell s defense system, membrane damage may occur. (scialert.net)
The opposing cell fates of daughter cells, i.e., to live or die, offer a compelling experimental system for investigating how epigenetic inheritance determines life versus death decisions during ACD. (elifesciences.org)
Taken together, our results show that PilC is an essential inner membrane component of the T4P system, controlling both pilus assembly and disassembly. (mcmaster.ca)

The causal link between the observed changes in the root metabolic profile and the regulation of transporter activity is discussed. (uab.cat)

Halothane alters surfactant biosynthesis and metabolism of alveolar type II cells. (asahq.org)
In addition to synthesizing surfactant, alveolar type II cells actively transport sodium (Na) from the alveolar space to the interstitium. (asahq.org)
Sodium, potassium-adenosine triphosphatase, and amiloride-sensitive Na channel activities are impaired by halothane in alveolar type II cells in vitro. (asahq.org)
The cells produced collagen type IV and the cellular form of fibronectin. (shengsci.com)
While the importance of cell type specificity in plant adaptive responses is widely accepted, only a limited number of studies have addressed this issue at the functional level. (uab.cat)

Anatomy23

Organisms8

Chemicals and Drugs92

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes21

Disciplines and Occupations1

Technology, Industry, Agriculture4

Information Science2

Health Care1

ATPase28

Proteins10

Vacuolar1

Triphosphate2

ATPases3

Permeability4

20161

Contraction2

Inner mitochon1

Outer membrane2

Adhesion1

Inhibition4

Physiology1

Mitochondrial1

Complex3

Inhibitor1

Erythrocyte membrane3

Ions3

Cytosolic2

Protein8

Osteoclasts2

Concentrations2

Enzyme1

Lipids1

Apical2

Exposure1

Bovine1

Sodium and potassium1

Basal1

Phosphorylation1

Biological activity1

Density1

Research2

Particles1

Muscle fibers2

Pump3

Calcium1

Macrophages1

Extracellular1

Growth1

Malignant1

Tissues2

System3

Regulation1

Type5