Cell matrix junctions. Medical search. Frequent questions

Its primary function is to give the cell its shape and mechanical resistance to deformation, and through association with extracellular connective tissue and other cells it stabilizes entire tissues. (wikipedia.org)
Moreover, it is involved in many cell signaling pathways and in the uptake of extracellular material (endocytosis), the segregation of chromosomes during cellular division, the cytokinesis stage of cell division, as scaffolding to organize the contents of the cell in space and in intracellular transport (for example, the movement of vesicles and organelles within the cell) and can be a template for the construction of a cell wall. (wikipedia.org)
Disruption of cell-cell junctions and digestion of extracellular matrix in tissues requires tissue-specific mechanical and chemical dissociation protocols. (olin.edu)
They interact through their extracellular domains to hold theadjacent plasma membranes together.The importance of desmosome junctions is demonstrated by some forms of thepotentially fatal skin disease pemphigus. (ostatic.com)
This results in a severe blistering of the skin, withleakage of body fluids into the loosened epithelium.Anchoring Junctions Formed by Integrins Bind Cells to theExtracellular Matrix: Focal Adhesions andHemidesmosomesSome anchoring junctions bind cells to the extracellular matrix rather than toother cells. (ostatic.com)
The transmembrane adhesion proteins in these cell-matrixjunctions are integrins a large family of proteins distinct from the cadherins.Focal adhesions enable cells to get a hold on the extracellular matrix through integrins that link intracellularly to actin filaments. (ostatic.com)
Connective tissue consists of cells, mainly fibroblasts , and an extracellular matrix ( ECM ). (amboss.com)
Connective tissue consists of specialized cells that are embedded in the extracellular matrix ( ECM ). (amboss.com)
The extracellular matrix ( ECM ) is composed of various macromolecules arranged in a three-dimensional structure. (amboss.com)
Differences in architecture and cell-surface morphology were observed in biofilms formed by the M1- and M41-wild-type strains, accompanied by varying amounts of deposited extracellular matrix and differences in cell-to-cell junctions within each biofilm. (cdc.gov)
dystrophin: Anchors the extracellular matrix to the cytoskeleton via F-actin. (assaygenie.com)
PDAC is characterized by extensive desmoplastic reaction, resulting in approximately 50% of tumor's volume consisting of non-tumor cells and extracellular matrix (ECM) stroma. (tau.ac.il)
Epithelial-mesenchymal transition (EMT) is a key cellular process in which immotile epithelial cells transform into mesenchymal cells through cell polarity loss, cell-cell junction disassembly, and extracellular matrix (ECM) alteration. (bmbreports.org)
MCTS mimic many of the features that tumors exhibit in the human body, including extracellular matrix (ECM) deposition between cells, gradients in nutrient concentration, and strong cell-cell junctions. (corning.com)
A complete bunk of technologies to study newly-formed cell junctions, extracellular matrix characteristics and fibroblasts activity. (bio-meca.com)
Extracellular matrix (ECM) rigidity serves as a crucial mechanical cue impacting diverse biological processes. (bvsalud.org)
Cells interact with the extracellular matrix (ECM) via cell-ECM adhesions. (bvsalud.org)
Single cell mesenchymal-type movement is characterized by an elongated cellular shape and again requires extracellular proteolysis and integrin engagement. (biomedcentral.com)
2 EndMT is a process by which endothelial cells lose a portion of their cellular features and obtain the mesenchymal phenotype, including the loss of tight junctions and increased production of extracellular matrix. (dovepress.com)
Several elements define the niche and regulate stem cell characteristics, such as stromal support cells, gap junctions, soluble factors, extracellular matrix proteins, blood vessels and neural inputs. (biostemtechnologies.com)
These miRNAs were predicted to reduce cell proliferation and extracellular matrix remodeling, endocytosis, Wnt signaling, ubiquitin-mediated proteolysis, and adherens junction function. (arvojournals.org)
1 - 3 The physiologic regulation of IOP is determined by aqueous humor outflow resistance, to which the endothelium of Schlemm's canal and extracellular matrix (ECM) within the trabecular meshwork (TM) make significant contributions. (arvojournals.org)
The cells of the heart muscle are equipped with three different types of extracellular cells intersections intermittently "point" desmosomes and "sheet" desmosomes (or adjacent fascia) - located in a specialized part of the plasma membrane, the intercalated disk. (mormonwoman.org)
This protein is found in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells. (medlineplus.gov)
Specifically, it is found in part of the extracellular matrix called the basement membrane, which is a thin, sheet-like structure that separates and supports cells in many tissues. (medlineplus.gov)

Focal adhesions are integrin-mediated cell matrix junctions connecting the ECM to the actin cytoskeleton. (rupress.org)
This model system reinforced the relevance of proteins associated with cell junctions, adhesions, and matrix in the cyst mechanism. (umaryland.edu)
It binds to ß-catenin/N-cadherin complexes in apical adherens junctions (AJs), which maintain cell-to-cell adhesions, and to talin/integrins in the focal adhesions (FAs) that attach cells to the basal membrane. (bvsalud.org)
Although cell-ECM interactions have been studied extensively, it is not completely understood how immature (nascent) adhesions develop into mature (focal) adhesions and how mechanical forces influence this process. (bvsalud.org)
TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells. (harvard.edu)

These properties imply an important role for cell-ECM interaction, making cell-matrix adhesion molecules, such as integrins, of special interest as possible candidate targets for future anti-PDAC therapies. (tau.ac.il)

The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including those of bacteria and archaea. (wikipedia.org)
The cytoskeleton can also contract, thereby deforming the cell and the cell's environment and allowing cells to migrate. (wikipedia.org)
The structure, function and dynamic behavior of the cytoskeleton can be very different, depending on organism and cell type. (wikipedia.org)
Even within one cell, the cytoskeleton can change through association with other proteins and the previous history of the network. (wikipedia.org)
In 1903, Nikolai K. Koltsov proposed that the shape of cells was determined by a network of tubules that he termed the cytoskeleton. (wikipedia.org)
The cytoskeleton provides the cell with structure and shape, and by excluding macromolecules from some of the cytosol, it adds to the level of macromolecular crowding in this compartment. (wikipedia.org)
Suppression of vinculin slows down the basal-to-apical part of interkinetic nuclear migration (BAINM), arrests neural stem cells (NSCs) in the G2 phase of the cell cycle, and ultimately dismantles the apical actin cytoskeleton. (bvsalud.org)
Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. (biomedcentral.com)
A common theme of these processes is a dynamic reorganization of actin cytoskeleton which has now emerged as a major switch control mainly carried out by Rho and Rac GTPase subfamilies, playing an acknowledged role in adaptation of cell motility to the microenvironment. (biomedcentral.com)
They are endowed with GTP hydrolytic activity, mainly involved in cytoskeleton rearrangements and cell motility, but also involved in cell proliferation, transformation and differentiation [ 2 ]. (biomedcentral.com)
9,10 It may be that RKI Y-27632 increases outflow facility by relaxing the cytoskeleton and disrupting the connectivity between inner wall endothelial cells and between JCT cells, which in turn may decrease resistance to aqueous by redistributing outflow patterns through looser regions in the JCT and the inner wall. (reviewofoptometry.com)

Likewise,when cultured fibroblasts migrate on an artificial substratum coated withextracellular matrix molecules, they also grip the substratum at focaladhesions, where bundles of actin filaments terminate. (ostatic.com)
At the ultrastructural level, gap junctions between the cytoplasmic processes of interfollicular fibroblasts constituted a novel observation. (nih.gov)
The main constituent of the human thyroid stromal tissue was a CD34 positive reticular network involving fibroblasts, mononuclear cells and nerve terminals. (nih.gov)
Cardiac fibroblasts are generally the primary effector cells of fibrosis and have been reported to be partly derived from cardiac endothelial cells through the endothelial to mesenchymal transition (EndMT) process. (dovepress.com)
The LMA is set into action by the paracrine factors released by human amniotic mesenchymal stem cells (MSCs) and their ability to accelerate the wound-healing process by stimulating proliferation and migration of dermal fibroblasts. (biostemtechnologies.com)

The majority of the working cells of the kidneys are epithelial cells that form the walls of the renal tubules, and their task is to move water and a large array of substances between the lumens of the tubules and the nearby network of blood vessels. (mhmedical.com)
The assembly of tight junctions between epithelial cells seems to require theprior formation of adherens junctions. (ostatic.com)
These antibodies bindto and disrupt the desmosomes that hold their skin epithelial cells(keratinocytes) together. (ostatic.com)
Therefore, a new in vitro tubuloid model was designed to investigate the proximate cellular changes in renal epithelial cells following inactivation of Pkd2, the gene that encodes for polycystin-2. (umaryland.edu)
Seeking connection between the junctions and disrupted apical compartment led to investigation of ezrin, a master scaffold in the apical compartment in renal epithelial cells. (umaryland.edu)
Understanding the relationship of ezrin, with PC2 in renal epithelial cells will help elucidate the mechanism of ADPKD cystogenesis and define important downstream pathways necessary for epithelial functions. (umaryland.edu)
Compared with follicular epithelial cells, there are a few morphological studies on the stroma of human thyroid gland. (nih.gov)
This study provides a detailed ultrastructural comparison of epithelial cells in the anterior chamber and the papillate region with focus on cuticle ultrastructure, apical and basal plasma membrane labyrinths, and cell junctions. (pensoft.net)
Na + /K + -ATPase activity in the hindgut epithelial cells was demonstrated by cytochemical localisation. (pensoft.net)
Basal parts of the epithelial cells are supported by a basal lamina and are exposed to haemolymph. (pensoft.net)
Herein we elaborated effects of TGF-β1 on TJs of primary human bronchial epithelial cells. (springer.com)
Lung epithelial cells form a barrier that lines airway and alveolar surfaces and constitute an air-liquid interface. (springer.com)

During fetal development, the subependymal germinal matrix is a site of neuronal proliferation as neuroblasts divide and migrate into the cerebral parenchyma. (medscape.com)
however, glial cell proliferation is still ongoing. (medscape.com)
The model is based on a novel assumption of elastic deformation of the cell layer and incorporates the following effects: i), mobility promoting force due to lamellipod formation, ii), mobility impeding adhesion to the cell matrix, and iii), enterocyte proliferation. (usuhs.edu)
In this report, we identified that KPNA3 was significantly upregulated in cancer cells, particularly in triple-negative breast cancer, and its knockdown resulted in the suppression of cell proliferation and metastasis. (bmbreports.org)
The ECM a researcher chooses has a significant effect on cancer cell proliferation, initiation, invasion, and metastasis, and it alters how the tumor model responds to drug therapy. (corning.com)
Glucagon-like peptide-1 (GLP-1) is an important endogenous incretin hormone, which stimulates glucose-dependent insulin secretion from the pancreatic islet cells and supports glucose homeostasis [ 7 ], as well as stimulating β -cell proliferation and inhibiting β -cell apoptosis, increasing insulin sensitivity, and inhibiting glucagon secretion and gastrointestinal motility [ 7 - 10 ]. (hindawi.com)
It is believed that TGF-β1 signalling is involved in controlling epithelial cell proliferation, to drive epithelial-mesenchymal transition (EMT) and it plays a major role in lung fibrosis and emphysema. (springer.com)
Cell proliferation in proper axillary and renal nodes, as well as in the spleen was also assessed. (cdc.gov)
It is concluded that dermal application of a contact allergen, as exemplified by OX and HCA, may induce cell proliferation in the neighboring lymph nodes and spleen indicative of hapten and/or haptenated proteins diffusing through the skin to periph- eral nodes and the blood to produce systemic sensitization. (cdc.gov)

In eukaryotes, it extends from the cell nucleus to the cell membrane and is composed of similar proteins in the various organisms. (wikipedia.org)
This study describes the identification of the unc-112 gene product, a novel, membrane-associated, intracellular protein that colocalizes with integrin at cell-matrix adhesion complexes. (illinois.edu)
We also have determined that UNC-112 is required to organize PAT-3/β-integrin after it is integrated into the basal cell membrane, but is not required to organize UNC-52/perlecan in the basement membrane, nor for DEB-1/vinculin to localize with PAT-3/β-integrin. (illinois.edu)
Furthermore, UNC-112 requires the presence of UNC-52/perlecan and PAT-3/β- integrin, but not DEB-1/vinculin to become localized to the muscle cell membrane. (illinois.edu)
TMPyP4 increased the percentage of cells with membrane damage associated with cell death and decreased the frequency of cells in the S-phase. (bvsalud.org)
Cell Membrane Structures" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Structures which are part of the CELL MEMBRANE or have cell membrane as a major part of their structure. (harvard.edu)
This graph shows the total number of publications written about "Cell Membrane Structures" by people in Harvard Catalyst Profiles by year, and whether "Cell Membrane Structures" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Cell Membrane Structures" by people in Profiles. (harvard.edu)
Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. (harvard.edu)
For example the inner membrane of mitochondria cells shields the inside matrix from the outside but shows - in contrast to old textbook illustrations - a lot of of handle-like junctions and therefore represents a higher genus surface. (mpg.de)

What is Cell Motility? (corning.com)
DermoMeca® provides solutions to investigate actives or skin care products effect on cell-cell junction robustness and cell motility. (bio-meca.com)
Collective motility leads to movement of cohorts of cells which maintain the adherens junctions and move by photolytic degradation of matrix barriers. (biomedcentral.com)
These two modes of cell movement are interconvertible and several moving cells, including tumor cells, show an high degree of plasticity in motility styles shifting ad hoc between mesenchymal or amoeboid movements. (biomedcentral.com)
This review will focus on the role of Rac and Rho small GTPases in cell motility and in the complex relationship driving the reciprocal control between Rac and Rho granting for the opportunistic motile behaviour of aggressive cancer cells. (biomedcentral.com)
Among other members, we will focus our attention on the Rac and Rho subfamilies, as they are the main effectors of cell motility. (biomedcentral.com)

These structures include-in order of the outflow of aqueous humor-the juxtacanalicular connective tissue [JCT], the inner wall of Schlemm's canal and, lastly, the lumen of Schlemm's canal. (reviewofoptometry.com)

The article, Electric-field facilitated rapid and efficient dissociation of tissues Into viable single cells shares the science behind the researcher's U.S. patent, wherein they invent and characterize a novel method and device to dissociate tissues with electric fields. (olin.edu)
Here, a new approach for dissociating tissues into constituent cells is described. (olin.edu)
Placing a tissue biopsy core within a liquid-filled cavity and applying an electric field between two parallel plate electrodes facilitates rapid dissociation of complex tissues into single cells. (olin.edu)
NIR can not cause ionization however have been shown to produce other biological effects, for instance by heating, altering chemical reactions or inducing electrical currents in tissues and cells. (intechopen.com)
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. (edu.au)
Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. (edu.au)
During host colonization GAS-cell aggregates or microcolonies are observed in tissues. (cdc.gov)
Enthesis development has historically been studied with lineage tracing of individual genes selected a priori, which does not allow for the determination of single-cell landscapes yielding mature cell types and tissues. (elifesciences.org)
Vascular endothelial cells (ECs) form a critical interface between blood and tissues that maintains whole-body homeostasis. (bvsalud.org)
Adjacent junctions (or contiguous zonula, indirect junction, or "strip desmosome") are protein complexes that occur in cell-cell junctions, cell-matrix junctions in epithelial and endothelial tissues usually more basic than tight connections. (mormonwoman.org)
Slotted nodes they are found in virtually all tissues of the body with the exception of adult, fully developed skeletal muscle and mobile cell types such as sperm or erythrocytes. (mormonwoman.org)

CypD knockdown (KD) significantly inhibited the binding of NOX 4 to Poldip 2, and mitochondrial ROS generation in human umbilical vein endothelial cells (HUVECs). (bvsalud.org)
In vitro, studies in human umbilical vein endothelial cells (HUVECs) and in silico network pharmacology analyses were performed to reveal the underlying mechanisms of GQP and determine the main components, targets, and pathways of GQP, respectively. (bvsalud.org)
An in vitro model of EndMT was developed using human umbilical vein endothelial cells (HUVECs) via treatment with transforming growth factor-β (TGF-β) at 10 ng/mL for 24 h. (dovepress.com)
Experimental manipulation of DNA methylation in engineered human umbilical vein endothelial cells indicated that the identified differentially methylated probes located at TRIM6 , TLN2, and FLRT2 genes may play a role in endothelial cell adhesion and atherosclerosis. (biomedcentral.com)
The potential functional role of DMPs was verified in a CRISPR/dCas9-Dnmt3a model in human umbilical vein endothelial cells (HUVECs). (biomedcentral.com)

Intercalated disks represent wavy double membranes in which two cells are tightly bound together by desmosomes and connected by gap junctions, allowing electrical impulses to pass from cell to cell . (mormonwoman.org)
Perlecan has multiple functions, including cell signaling and the normal maintenance of basement membranes and cartilage. (medlineplus.gov)

The unc-52 (perlecan), pat-2 α-integrin), and pat-3 (β-integrin) genes encode ECM or transmembrane proteins found at the cell - matrix adhesion sites of both dense bodies and M-lines. (illinois.edu)
The particular type of intermediate filaments attached tothe desmosomes depends on the cell type: they are keratin filaments in mostepithelial cells, for example, and desmin filaments in heart muscle cells.The junction hasa dense cytoplasmic plaque composed of a complex of intracellular anchorproteins (plakoglobin and desmoplakin) that are responsible for connecting thecytoskeleton to the transmembrane adhesion proteins. (ostatic.com)
These adhesion proteins(desmoglein and desmocollin), like those at an adherens junction, belong to thecadherin family. (ostatic.com)

TGRL Lipolysis Products Induce Stress Protein ATF3 via the TGF-β Receptor Pathway in Human Aortic Endothelial Cells. (ucdavis.edu)
The ROCK signaling pathway promotes cell contractility and adhesion of fibroblast cells (e.g. (reviewofoptometry.com)

Figure 2: Postulated G-protein-mediated signal transduction process in normal and regenerating endothelial cells. (nature.com)
Collagen is the most abundant fibrous protein found in mammals' ECMs, and it plays a critical role in tumor growth and metastasis because it promotes cell adhesion and migration. (corning.com)
Here, polymerase-interacting protein 2 (Poldip 2) was found in the endothelial mitochondrial matrix and no effects on Poldip 2 and NADPH oxidase 4 (NOX 4) expression treated by Ang II. (bvsalud.org)
Ceramide sets off many pathways that creates endothelial cell loss of life, including activation of caspases, or PP2A2 or PP1,55, and raising mitochondrial permeability by developing ceramide-enriched platforms with the capacity of translocating protein. (moonphase2018.com)

Collagen type I hydrogels have been used to grow MCTS from osteosarcomas, breast cancer cells, human colorectal cancer cells, prostate cancer cell lines, and primary cancer cells from colorectal cancer patients, according to the Science Advances study. (corning.com)

Bogataj U, Praznik M, Mrak P, Štrus J, Tušek-Žnidarič M, Žnidaršič N (2018) Comparative ultrastructure of cells and cuticle in the anterior chamber and papillate region of Porcellio scaber (Crustacea, Isopoda) hindgut. (pensoft.net)

Such development pattern shares an overlapping biological behavior with the growth plate, which is a process of mesenchymal stem cells differentiating into chondrogenic cells and then sequentially into fibrocartilage cells ( Killian, 2022 ). (elifesciences.org)

Immunohistochemistry using a monoclonal antibody against Cx43 confirmed the distribution of gap junctions between stromal fibroblastic cells, which was compatible with the ultrastructural findings. (nih.gov)

Biochemical and molecular aspects of cellular function, interactions and communication including cell cycle, apoptosis, cancer, neuronal transmission and the signal transduction pathways that integrate them. (sfu.ca)
In vitro study showed that exendin-4 (the active ingredient of exenatide) attenuated HUVECs injury induced by high glucose, with improving cell viability and attenuating cell apoptosis. (hindawi.com)

As it projects a long dorsally directed cellular extension, the cap cell reorients the dendrite of the v'ch1 neuron and tows its cell body dorsally. (biologists.com)
This triggered an increase in paracellular permeability via cellular redistribution of claudin 3 (CLDN3) from TJs into cell nuclei followed by disruption of epithelial integrity and formation of epithelial lesions. (springer.com)
In quick succession, the preimplantational mouse embryo undergoes a series of cellular divisions involving two critical cell fate decisions. (zeiss.com)
To determine which cells are expressing specific cellular markers and how these cells are organized relative to each other requires volumetric imaging of the pre-implantation embryos by confocal microscopy. (zeiss.com)

Live imaging identifies dynamic and transient F-actin-based structures, such as filopodia, contractile ring and cell cortex, and more persistent F-actin-based structures, such as cell junctions. (biologists.com)
Heart cells are special among muscle types because they are connected to each other by intercalated disks - structures that are it only occurs in the heart Muscle cells. (mormonwoman.org)
At the heart, the heart muscle cells (myocytes) are connected end-to-end by structures known as intercalated disks. (mormonwoman.org)

Ionizing radiations are extremely high frequency electromagnetic waves (X-rays and gamma rays), which have enough photon energy to produce ionization by breaking the atomic bonds that hold molecules in cells together. (intechopen.com)
However, endothelium that has regenerated after percutaneous coronary intervention is incompetent in terms of its integrity and function, with poorly formed cell junctions, reduced expression of antithrombotic molecules, and decreased nitric oxide production. (nature.com)
A reduced amount of functional perlecan at the neuromuscular junction likely alters the balance of other molecules that signal when muscles should contract and when they should relax. (medlineplus.gov)

The attachment site of the rotator cuff (RC) is a classic fibrocartilaginous enthesis, which is the junction between bone and tendon with typical characteristics of a fibrocartilage transition zone. (elifesciences.org)
Skeletal muscle tissue cells define four characteristics: they are voluntary, striated, unbranched and multi-nuclear. (mormonwoman.org)

During contraction of a muscle, within each muscle cell, myosin molecular motors collectively exert forces on parallel actin filaments. (wikipedia.org)
Myosin and actin are not organized into sarcomeres in the body wall muscle cells of these mutants, and dense body and M-line components fail to assemble. (illinois.edu)
Adherens Junctions Connect Bundles of Actin Filaments from Cell to Cell. (ostatic.com)
Actin filaments are instrumental in driving processes such as migration, cytokinesis and endocytosis and provide cells with mechanical support. (biologists.com)
During angiogenesis, actin-rich filopodia protrusions have been proposed to drive endothelial tip cell functions by translating guidance cues into directional migration and mediating new contacts during anastomosis. (biologists.com)
To investigate the structural organisation, dynamics and functional importance of F-actin in endothelial cells (ECs) during angiogenesis in vivo , we generated a transgenic zebrafish line expressing Lifeact-EGFP in ECs. (biologists.com)

TMPyP4 reduced cell adhesion ability and modified the pattern of focal adhesion. (bvsalud.org)

Component of the dystrophin- associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. (assaygenie.com)

Upon the introduction of cracks, the composite-reinforced cells exhibit virtually zero loss in short-circuit current density, while retaining a spatially contiguous electroluminescence," stated Osazda. (pv-magazine.com)

As the cap cell maintains a close physical connection with the tip of the dendrite, the latter is dragged into an abnormal position and orientation, and the neuron fails to undergo its normal dorsal migration. (biologists.com)
Cells exhibit three distinct modes of migration when invading the 3 D environment. (biomedcentral.com)
In addition, TMZ effectively inhibited EndMT in ISO-treated rat hearts and TGF-β-treated HUVECs, as manifested by increased CD31 expression, decreased α-SMA expression, and suppressed cell migration. (dovepress.com)

Crossing the tubular epithelium can occur either through the cells or around the cells. (mhmedical.com)
Adherens junctions occur in various forms. (ostatic.com)

Do myocardial cells have gap junctions? (mormonwoman.org)

According to the developers, composite-reinforced cells offer better performance than multi-junction devices produced with traditional metallization processes, even when the cell is intentionally cracked. (pv-magazine.com)
Thus, the present results showed that TMPyP4 and TQ, although acting as telomerase inhibitors, had a broader effect on other signaling pathways and processes in cells, differing from each other. (bvsalud.org)
Moreover, increasing number of studies have highlighted the fact that a multifaceted approach from various domains of science such as biomechanics, cell biology, bioengineering, biophysics, biomaterials, computational modelling, endocrinology, and orthopaedics is essential to further our understanding of the intricate processes involved in bone remodelling and the central role of osteocytes in maintaining bone mass and architecture. (pharmaceuticalintelligence.com)

Through desmosomes, the intermediatefilaments of adjacent cells are linked into a net that extends throughout themany cells of a tissue. (ostatic.com)
The Assay Genie Human Dystrophin ELISA is a highly sensitive assay for the quantitative measurement of Dystrophin in serum, blood, plasma, cell culture supernatant and tissue samples. (assaygenie.com)
Do your tissue allografts have live cells? (biostemtechnologies.com)
TGF-β1 is a major mediator of airway tissue remodelling during atopic asthma and affects tight junctions (TJs) of airway epithelia. (springer.com)
The conducting system of the heart consists of cardiac muscle cells and conducting fibers (not nervous tissue) that are specialized for initiating impulses and conducting them rapidly through the heart (see the image below). (medscape.com)
The sinoatrial (SA) node is a spindle-shaped structure composed of a fibrous tissue matrix with closely packed cells. (medscape.com)

In human studies, though, the morphological changes in the JCT/inner wall region differed from the animal studies, and therefore warrant further investigation. (reviewofoptometry.com)

In skeletal muscle cells, T-tubules are three to four times narrower than in cardiac cells, and are 20 to 40 nm in diameter. (mormonwoman.org)

The germinal matrix supports the division of glioblasts and differentiation of glial elements until approximately 32 weeks' gestation, at which time regression is nearly complete. (medscape.com)

The study's results confirmed previous findings that a treatment protocol of cisplatin and radiation was superior to radiation alone and confirmed the feasibility of using primary tumor cells for spheroid formation, which could yield MCTS that more closely mimic in vivo tumor behavior. (corning.com)
Spheroids have also been used to study transcoelomic metastasis in ovarian cancer, in which primary tumor cells seep into the abdominal cavity, where they form spheroids and then travel through fluids to secondary sites. (corning.com)

Journal of Cell Biology , 150 (1), 253-264. (illinois.edu)
Molecular Biology of the Cell , 7th edition. (sfu.ca)

J Cell Biol (2007) 176 (1): 43-49. (rupress.org)
Nat Cell Biol. (harvard.edu)
Mol Cell Biol. (harvard.edu)

Smooth muscle cells they are spindle-shaped, have a single, centrally located nucleus and no striations. (mormonwoman.org)

The chief advancement among these was the breakthrough of FTY720 (fingolimod), a sphingosine analogue that alters immune system cell trafficking and has already been being found in the medical clinic for the treating multiple sclerosis4. (moonphase2018.com)

Triglyceride-rich lipoprotein lipolysis products increase blood-brain barrier transfer coefficient and induce astrocyte lipid droplets and cell stress. (ucdavis.edu)

Conversely, in amoeboid movement cells have a rounded morphology, the movement is independent from proteases but requires high Rho GTPase to drive elevated levels of actomyosin contractility. (biomedcentral.com)

Thus, ceramides control essential endothelial cell features that are usually in charge of the pathogenesis connected with vascular dysfunctions, including emphysema, sepsis and severe respiratory distress symptoms. (moonphase2018.com)
and (4) functional validation of top hits in an endothelial cell model via the CRISPR/dCas9-Dnmt3a system. (biomedcentral.com)

this suggests that the novel independent signaling pathways KPNA3-TGF-β-GATA3-HAS2/E-cadherin and KPNA3-AKT-HAS2/E-cadherin are involved in the EMT-mediated progress of TNBC MDA-MB-231 cells. (bmbreports.org)
In this study, it was found that KPNA3 regulates numerous EMT-related genes and induces the EMT process via at least two independent signaling pathways in the highly invasive triple-negative breast cancer (TNBC) cell line MDA-MB-231. (bmbreports.org)
Osteocytes are the most abundant cell type in bone and are responsible for sensing mechanical strain and signaling bone (re)modeling, making them the primary mechanosensors within the bone. (pharmaceuticalintelligence.com)

These physical interactions are transduced into biochemical signals inside the cell which influence cell behaviour. (bvsalud.org)

And, we furtherly performed single-cell spatial transcriptomic sequencing on postnatal day 1 mouse enthesis, in order to deconvolute bone-tendon junction (BTJ) chondrocytes onto spatial spots. (elifesciences.org)
Bone marrow failure-Functional role of Bone marrow stromal cells. (nii.ac.jp)
95% of bone cells . (pharmaceuticalintelligence.com)

One of the main role of these cells is to regulate epidermis permeability. (bio-meca.com)

Cells of the germinal matrix are rich in mitochondria and, therefore, are quite sensitive to ischemia. (medscape.com)

Cells specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. (edu.au)
We also demonstrated that ECM rigidity positively regulates the pN force of T cell receptor-ligand bond and T cell receptor mechanical sampling frequency, promoting T cell activation. (bvsalud.org)

This paper represents a valuable single-cell level analysis of tendon enthesis development. (elifesciences.org)

STUDY DESIGN: We tested our hypothesis in a carrageenan-induced thrombosis mouse model in vivo and lipopolysaccharide (LPS)-induced human endothelial cells (HUVECs) in vitro. (bvsalud.org)

Cyst yield was optimal (70%) when a density of 5 X 10(5) cells/ml was employed for the inoculum. (typeset.io)

Anatomy51

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