Cell malignant. Medical search. Frequent questions

In melanoma, the malignant black skin cancer, such T-cell receptor transgenic T cells have already been shown to prolong the lives of some patients. (dkfz.de)
Healthy humans develop spontaneous CD8+ T cell responses to melanoma associated antigens (MA) expressed by normal melanocytes. (mdpi.com)
5 ). Data from case reports, case series, cohort studies, in Cutavirus in Malignant vitro work, and animal studies indicate that the infectious Melanoma period for sexual transmission of Zika virus is consider- ably shorter than the period during which viral RNA can be detected in semen. (cdc.gov)
Malignant melanoma is the most aggressive type of skin cancer, which initiates in the pigment-producing cells called melanocytes. (lu.se)
Therefore, it is of importance to identify the molecular mechansims that drive metastasis of melanoma cells. (lu.se)
High expression of wingless-type MMTV integration site family 5A (WNT5A) has been reported in melanoma and correlates with increased migration and invasion of melanoma cells. (lu.se)
In this thesis, we investigate that WNT5A and interleukin-6 (IL-6) form a positive feedback loop, which accelerates the invasive property of melanoma cells. (lu.se)
In addition, we demonstrate that combined targeting of IL-6 signaling and WNT5A expression, using an anti-IL-6 antibody and a WNT5A antagonist peptide (Box5), respectively, more effectively reduces melanoma cell dissemination, as compared to each factor alone. (lu.se)
Moreover, we show that the RNA-binding protein human antigen R (HuR) drives melanoma cell motility, and targeting HuR with a specific HuR inhibitor, MS-444, significantly reduces melanoma cell migration. (lu.se)
Further analyses revealed that simultaneously targeting HuR, with MS-444, and WNT5A signaling, with Box5, reduces melanoma cell migration and invasion via two different and partially overlapping signaling pathways, which are PKC and PI3K-AKT. (lu.se)
Our results also show that acquired BRAF-inhibitor (BRAFi) resistance leads to increased expression of HuR and WNT5A in malignant melanoma cells, and simultaneous therapeutic inhibition of HuR function and WNT5A signaling could be an efficient treatment strategy to impair the invasive migration of BRAFi-resistant melanomas. (lu.se)
Taken together, our results extend our knowledge about WNT5A regulation in melanoma and highlight the importance of HuR and WNT5A in melanoma cell migration and invasion. (lu.se)
Malignant melanoma (MM) is one of the high degree of malignancy and early prone to blood and lymph node metastasis. (biomedcentral.com)
We tested the effects of Tan II A on melanoma A375, MV3, M14, and other human cell lines including Hacat and HUVEC cells in cell culture model. (biomedcentral.com)
Cell migration ability melanoma A375 was monitored by using cell scratch assay. (biomedcentral.com)
Transwell chamber experimental was performed to assess the effect of Tan II A on A375 melanoma cell invasion ability. (biomedcentral.com)
We found that Tan IIA inhibited melanoma A375, MV3, and M14 cell proliferation in dose and time dependent manner. (biomedcentral.com)
Patients with oral malignant melanoma often recall having an existing oral pigmentation months to years before diagnosis, and the condition may even have elicited prior comment from examining physicians and dentists (or healthcare providers, when considering the auxiliaries). (medscape.com)
Deletion of the proximal enhancer decreases CCL5 expression and augments the cytotoxic activity of tissue-resident T and NK cells, which coincides with reduced melanoma metastasis in mouse models. (nature.com)
A history of prior squamous cell carcinoma , malignant melanoma , or malignant fibrous histiocytoma suggests intraglandular metastasis or metastasis to parotid lymph nodes. (medscape.com)

Herein we investigated the effects of parsley root extract (PCE) on DNA synthesis performance, metabolic activity and cytotoxicity in malignant and benign breast cells. (iiarjournals.org)
Melanomas can be either malignant or benign. (akc.org)
While benign melanomas are more common, malignant melanomas are a serious concern, as they grow quickly and have a high risk of metastasis (spreading to other organs). (akc.org)
Cellular phone use and risk of benign and malignant parotid gland tumors--a nationwide case-control study. (greenmedinfo.com)
The study included 402 benign and 58 malignant incident cases of PGTs diagnosed in Israel at age 18 years or more, in 2001-2003, and 1,266 population individually matched controls. (greenmedinfo.com)
Women with benign (non-cancerous) germ cell tumors such as mature teratomas (dermoid cysts) are cured by removing the part of the ovary that has the tumor (ovarian cystectomy) or by removing the entire ovary. (cancer.org)
Benign clear cell adenofibroma of the ovary. (nih.gov)
Benign, of low malignant potential, and associated with invasive clear cell carcinoma. (nih.gov)
Primary brain tumors, which are tumors that originate in the brain, can be either benign or malignant. (northshore.org)
Of patients with malignant parotid tumors, 7-20% present with facial nerve weakness or paralysis, which almost never accompanies benign lesions and indicates a poor prognosis. (medscape.com)
Bone tumors may be cancerous (malignant) or noncancerous (benign). (msdmanuals.com)

Previous studies revealed that inhibition of miR-744-3p could restore PTEN expression, and then suppressed laryngeal squamous cell carcinoma progression [ 20 ], suggesting that upregulation of PTEN could contribute to cancer development. (hindawi.com)
Squamous cell carcinoma is by far the most common malignancy of the tongue, typically having 3 gross morphologic growth patterns: exophytic, ulcerative, and infiltrative. (medscape.com)
Clinical appearance of a lateral tongue squamous cell carcinoma in an 80-year-old man with a previous history of smoking and regular alcoholic beverage consumption. (medscape.com)
Indications are that the incidence of squamous cell carcinoma of the mobile tongue has been rising among younger women in industrialized nations. (medscape.com)
The report found that the incidence of primary mobile tongue squamous cell carcinoma has significantly risen in persons under age 45 years within the populations of Australia and Singapore, with the rate of increase being significantly higher in females. (medscape.com)
A study by Joseph et al found that the incidence of squamous cell carcinoma of the oral tongue has risen among white females in the United States while at the same time decreasing among African American women. (medscape.com)
The report also found the estimated 1-, 5-, and 10-year relative survival rates for squamous cell carcinoma of the oral tongue to be greater in white women than in African American females, but following multivariable analysis, the investigators attributed the higher survival rate not to race but to such factors as lower stage, younger age, married status, and receipt of surgical treatment. (medscape.com)

In this study, the human bronchial epithelial cells (16HBE) were treated five times with 1 ?M benzo(a)pyrene (BaP), followed by 2 passages culture, and thein vitroBaP-induced malignant transformation of 16HBE cells was established. (eurekamag.com)
As with epithelial ovarian cancers, it is a good idea to consult with a gynecologic oncologist for treating malignant germ cell tumors, especially because these are so uncommon. (cancer.org)
In general, all women with malignant germ cell tumors will have the same staging surgery that is done for epithelial ovarian cancer. (cancer.org)
A malignant neoplasm of the ovary with an invasive epithelial component and a fibrotic stroma. (nih.gov)
The epithelial component is characterized by the presence of malignant epithelial cells with clear cytoplasm. (nih.gov)
Smears that contained alveolar macrophages and bronchial epithelial cells were deemed sufficient. (ganeshdiagnostic.com)

Topotecan is a novel topoisomerase I inhibitor that may have a role in the adjuvant chemotherapy of several solid tumors, including malignant glioma. (aspetjournals.org)

MiR-29a-3p was enriched in hBMSC-derived Exo, and the Exo from miR-29a-3p mimics transfected hBMSCs could inhibit laryngocarcinoma cell malignant phenotypes in vitro and prevent tumor progression in vivo . (hindawi.com)
DNAJB7-specific T cells were capable of killing colorectal tumor lines in vitro, and the IFN-gamma+ response was markedly magnified by control of immunosuppression with cyclophosphamide in cancer patients. (cardiff.ac.uk)
Functional experiments showed that PHKB knockdown significantly promoted cell proliferation both in vitro and in vivo , whereas PHKB overexpression resulted in opposing effects. (ijbs.com)
Additionally, in vitro assays revealed that the over (or high) expression of PHKB greatly hindered HCC cell invasion and increased apoptosis rates. (ijbs.com)

CD95 ligand (CD95L)-induced apoptosis was synergistically enhanced by short-term/high concentration but not long-term/low concentration exposure to topotecan, suggesting that topotecan sensitizes human malignant glioma cells to CD95L-induced apoptosis via inhibition of RNA synthesis. (aspetjournals.org)

Call for an appointment with your provider if you have symptoms of malignant mesothelioma. (medlineplus.gov)

Results: Studies to date have shown that human T-cells engineered to express cMet CARs can destroy mesothelioma tumour cell monolayers, accompanied by T-cell proliferation and cytokine production. (aacrjournals.org)
Conclusions: These findings demonstrate proof of concept for the utility of CAR engineered T-cells to recognise and destroy cMet-expressing MPM tumour cells. (aacrjournals.org)
Malignant tumour seems to occur more likely on the left side according to an analysis of cancer data from Australia and other developing countries. (medindia.net)

In addition, lung metastasis was observed in nude mice in T-16HBE-C1, 3 and 4 groups.In vitrocell migration assay results indicated that T-16HBE-C2?5 cells showed much lower migration capabilities than 16HBE cells. (eurekamag.com)
Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells. (nii.ac.jp)
Previous studies had confirmed that Lasp1 was significantly overexpressed in multiple malignant tumors including non-small-cell lung cancer (NSCLC) and enhanced tumor proliferation, invasion and metastasis [ 7 - 13 ]. (oncotarget.com)
Firstly, the transcriptome landscape of heterogeneous cell types in LUAD was analyzed and memory T cells, NK cells, and helper T cells were revealed to be the common immune cells in tumor, normal, and metastasis tissue, respectively. (aging-us.com)
Next, the results of cell-cell communication analysis suggested that pericytes interact with broad immune cells via MDK-NCL pathways in metastasis samples, MIF-(CD74+CXCR4) and MIF-(CD74+CC44) interaction especially occurred between different cell types in tumor and normal samples. (aging-us.com)
In this study, we collected single-cell sequencing datasets of LUAD and applied an integrated bioinformatic method to depict the transcriptome characteristic of LUAD in normal, tumoral, and metastasis condition. (aging-us.com)
In recent years, although significant progress has been made in the diagnosis and treatment of malignant tumors, breast cancer remains the leading cause of cancer-related deaths in women, largely due to its high rate of relapse, metastasis, and drug resistance [2-5]. (researchsquare.com)

Lukas Bunse, a scientist at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and a physician at the University Medical Center Mannheim, relies on the comparatively new concept of "T cell receptor transgenic cells" in his current study: To this end, brain tumor patients were first inoculated with an antigenic fragment of the protein NLGN4X (Neuroligin4X). (dkfz.de)
Clinical studies show that new drugs that target malignant cells of HER2-positive breast cancer, such as Pertuzumab and Trastuzumab Emtansine (T-DM1), increase life expectancy in patients with advanced breast cancer. (news-medical.net)
High micromolar concentrations of topotecan, which are unlikely to be achieved in plasma in human patients in vivo , were cytotoxic within 48 hr, induced DNA fragmentation, did not induce major cell cycle changes, failed to consistently alter BCL-2 or BAX protein levels but inhibited RNA synthesis and induced cleavable DNA/topoisomerase I complex formation. (aspetjournals.org)
Patients are in need of new treatments that can improve survival outcomes, and these positive results support the potential of KEYTRUDA in combination with chemotherapy as a first-line treatment for patients with the most common form of malignant mesothelioma. (merck.com)
There have been few treatment advances for patients with malignant pleural mesothelioma, which can be challenging to treat through surgery and radiation alone," said Dr. Quincy Chu, CCTG's study chair of the IND.227 trial/KEYNOTE-483 trial. (merck.com)
The trial evaluated KEYTRUDA in combination with chemotherapy for the treatment of patients with unresected advanced malignant pleural mesothelioma. (merck.com)
Serial MR imaging was performed in 18 consecutive patients with recurrent malignant gliomas receiving both thalidomide and carboplatin for 12-month periods. (ajnr.org)
With advances in adjuvant chemotherapy, patients with malignant gliomas are living longer and there is a need for more sophisticated imaging surveillance of tumor progression. (ajnr.org)
MR imaging studies were performed in 18 consecutive patients with recurrent malignant gliomas who were enrolled in a trial to investigate treatment with thalidomide and carboplatin (9) . (ajnr.org)
Six patients (three men and three women, 27-64 years old, mean age, 46 years) undergoing high-dose carboplatin therapy without thalidomide for recurrent malignant gliomas served as a control group. (ajnr.org)
Determine the concentration of interleukin-13 PE38QQR immunotoxin that produces histologic evidence of toxicity to tumor and the corresponding toxic effects of this drug when administered via continuous intratumoral infusion prior to second resection in patients with recurrent resectable supratentorial malignant glioma. (knowcancer.com)
Resection (all patients): Patients undergo maximal resection (en bloc, if feasible) followed by placement of 2-3 peritumoral catheters (4 days after completion of pre-resection infusion for the initial cohorts of patients and at study entry for subsequent cohorts of patients). (knowcancer.com)
La présente étude a estimé les fréquences relatives du cancer de la cavité buccale et du pharynx chez des patients yéménites atteints de cancers enregistrés en 2007 et 2008. (who.int)

Bunse's team then demonstrated that the NLGN4X-specific T cells are able to kill brain tumor cells in the culture dish. (dkfz.de)
Brain tumor-bearing mice treated with transgenic NLGN4X-specific human T cells had a greater than 40 percent response to treatment. (dkfz.de)
After these initial studies had yielded such promising results, Lukas Bunse expects that vaccine-induced T-cell receptors targeting brain tumor antigens could be a promising approach to develop new immunotherapies against glioblastoma. (dkfz.de)
Glioblastoma multiforme (malignant brain tumor) cells. (mayoclinic.org)

The aim of this study was to find out the characteristic morphology of malignant atypical cells which were missed on routine cytology of urine. (cytojournal.com)
In this retrospective study, we examined detailed cytomorphology of 18 cases of atypical urinary cytology which were missed on routine examination and were further proved on histopathology as transitional cell carcinoma (TCC) of bladder. (cytojournal.com)
Necrosis in the background and necrosed papillae were mostly seen in malignant atypical cells. (cytojournal.com)
The comet cells and cells with India ink nuclei (single cells with deep black structure-less nuclei) were only observed in malignant atypical cells. (cytojournal.com)
The present study emphasizes that nuclear features such as high N/C ratio, hyperchromasia and chromatin abnormalities are particularly useful for assessing the malignant atypical cells. (cytojournal.com)
Atypical cells" in urine have been recognized and studied time and again 2 3]. (cytojournal.com)
The accurate interpretation of the character of "Atypical cell" in urine is a major challenge for cytopathologists. (cytojournal.com)
In this present paper we analyzed the characteristic morphology of malignant atypical cells which were missed on routine cytology of urine. (cytojournal.com)
A total of 58 urine samples reported as positive for atypical cells were initially selected. (cytojournal.com)
Histopathological changes in the tumors indicated nests growth, high nuclear-cytoplasmic ratios, coarse and clumped chromatin, numerous and distinctly atypical mitoses, cell necrosis and surrounding normal adipose, muscle and connective tissue immersed. (eurekamag.com)
However, with the addition of the clot preparation, the number of cases in which atypical/malignant cells were seen increased from 42 to 85 (19.4%), with a P (bvsalud.org)
The excellent adequate tory smears were divided into four categories: inflammatory, suspicious/atypical favouring neoplasia, and positive for malignant cells. (ganeshdiagnostic.com)

It is found in large quantities in glioblastoma cells, but is virtually undetectable in healthy brain tissue. (dkfz.de)
Bunse's team then isolated from the blood of the vaccinated individuals those T cells that had been activated by NLGN4X and consequently carried a T cell receptor that specifically "recognizes" this glioblastoma-associated antigen. (dkfz.de)

Malignant mesothelioma is an uncommon cancerous tumor . (medlineplus.gov)
Some tumors are cancerous, or malignant. (cdc.gov)
This condition rarely becomes cancerous (malignant). (msdmanuals.com)

Much more advanced in clinical development than T-cell receptor transgenic cells are cellular therapies using so-called CAR-T (chimeric antigen receptor) cells, which have already been approved for the treatment of various leukemias and lymphomas. (dkfz.de)
Background A synergistic effect resulting from a combination of BCL2 and MYC or MYC and CCND1 has been implicated in human B-cell lymphomas. (haematologica.org)
Genetic alterations of BCL2 (B-cell CLL/lymphoma 2), MYC [v-myc myelocytomatosis viral oncogene homolog (avian)] and CCND1 (cyclin D1) are the most frequently found alterations in human B-cell lymphomas. (haematologica.org)
7 Importantly, it is believed that other hitherto unknown genes also play important roles in lymphomagenesis in addition to the synergistic effects of the aforementioned two oncogenes since human B-cell lymphomas often show a variety of genes subject to alterations and/or deregulated expression. (haematologica.org)
Her research interest is in Zika virus infection and cell lymphomas (CTCL) ( 1 , 2 ). (cdc.gov)
Significant differences in survival were revealed when comparison was made with developing countries, for people with cancers that can be successfully treated by chemotherapy (malignant lymphomas, leukaemia, testicular tumours) and modest differences for neoplasms that can be cured by early detection and surgical intervention. (who.int)

Our results demonstrated that BaP could induce the malignant transformation of 16HBE cells, and p53 and p-Akt (Ser473) might play crucial roles in BaP-induced carcinogenesis. (eurekamag.com)
In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. (nii.ac.jp)
Oral blue nevi are not reported to undergo malignant transformation. (medscape.com)

Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary. (nih.gov)
The cytological methods currently available for examining the pathology of the lung include exfoliative (induced sputum), abrasive (bronchoalveolar lavage [BAL], bronchial brushing [BB], bronchial washing, and percutaneous/endobronchial fine-needle aspiration cytology), and percutaneous/endobronchial cytology.BBs have a higher cell yield than aspirates and washing. (ganeshdiagnostic.com)

Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas. (stembook.org)
The purpose of our study was to compare postcontrast T1-weighted imaging with dynamic, contrast-enhanced T2*-weighted echo-planar imaging in the evaluation of the response of recurrent malignant gliomas to thalidomide and carboplatin. (ajnr.org)
Tumor progression was evaluated clinically using established criteria for malignant gliomas. (ajnr.org)

This drug that attaches to the antibody called emtansine, enters the interior of the cell and releases chemotherapy molecules, thereby directly attacks the HER2 positive tumor cells, increasing life expectancy and causing fewer side effects. (news-medical.net)
Most types and stages of germ cell cancers of the ovary are treated the same way, with surgery and chemotherapy (chemo). (cancer.org)

Background: Malignant pleural mesothelioma (MPM) is an incurable cancer predominantly induced by asbestos exposure. (aacrjournals.org)
Malignant pleural mesothelioma is a rapidly progressing cancer that develops in the lining of the lungs and has a poor prognosis," said Dr. Eliav Barr, senior vice president, head of global clinical development and chief medical officer, Merck Research Laboratories. (merck.com)
Pleural mesothelioma, which develops in the lining of the lungs, is the most common form of malignant mesothelioma, accounting for about 75% of all cases. (merck.com)

Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
Although several studies revealed the important role of immune cells and related marker genes impact on LUAD prognosis and process, a comprehensive understanding of TIME malignant and metastatic change in LUAD is still limited. (aging-us.com)

In susceptible individuals, the medications induce the release of stored calcium ions within muscle cells. (wikipedia.org)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

The researchers have ruled out the possibility that the greater occurrence of the malignant tumours on the left side of the body was because one arm is exposed to the sun while driving or due to uneven sun-block application. (medindia.net)

Clear cell carcinoma of the ovary: is there a role of histology-specific treatment? (nih.gov)

MiRNAs can also control the self-renewal or proliferation of stem cells [9]. (researchsquare.com)

Mesenchymal tumors include structures arising from mesodermal-derived precursor cells that develop into cartilage, bone, or other connective tissues. (newhopemedicalcenter.com)
The miR-29a-3p level was decreased, and PTEN level was elevated in laryngocarcinoma tissues and the cancer cell lines. (hindawi.com)
In the somatic tissues, the stem cells expressed telomerase-associated RNA, but no proliferation activity. (nih.gov)
The study of tissues and cells under a microscope. (cdc.gov)
Cells from malignant tumors can invade nearby tissues. (cdc.gov)

MiR-125b participates in the oncogenic role of lncRNA MALAT1 in the phenotypes including cell proliferative and invasive rates in laryngocarcinoma [ 6 ]. (hindawi.com)
Yang W, Zhang C, Li Y, Jin A, Sun Y, Yang X, Wang B, Guo W. Phosphorylase Kinase β Represents a Novel Prognostic Biomarker and Inhibits Malignant Phenotypes of Liver Cancer Cell. (ijbs.com)

Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD. (lu.se)
Here, making use of a newly generated Pdgfd knockout mouse, we reveal a functionally important malignant cell heterogeneity modulated by PDGF-DD signaling in pancreatic neuroendocrine tumors (PanNET). (lu.se)

Worldwide, it is estimated there were more than 30,000 new cases of malignant mesothelioma diagnosed and more than 26,000 deaths from the disease in 2020. (merck.com)
Although incidence of malignant mesothelioma has gradually declined in the United States, continued use of and exposure to asbestos around the world has resulted in increasing global rates of this aggressive disease. (merck.com)
Autophagy plays an important role in cell growth, development and disease suppression. (biomedcentral.com)

In this way, they succeeded in producing large numbers of T cells with identical specificity, all of which recognize the cancer antigen NLGN4X. (dkfz.de)
According to the scientist, it is also conceivable to generate T cell receptor transgenic cell therapies against patient-individual cancer antigens. (dkfz.de)
Such is the case of Trastuzumab and Pertuzumab Emtansine (T-DM1) monoclonal antibodies, which are directed to the HER2 gene that promotes the growth of cancer cells. (news-medical.net)
According to data from the Mexican Institute of Geography and Statistics (INEGI) in 2012, from every hundred women over the age of 20 who died of malignant tumors, 15 were from breast cancer. (news-medical.net)
The goal of our alternative treatments for granular cell tumors is to stimulate the spontaneous regression of cancer cells and ultimately light your path toward remission. (newhopemedicalcenter.com)
As a common malignant tumor in the upper respiratory tract, laryngocarcinoma accounts for approximately 25 to 30% of cancer cases worldwide [ 1 , 2 ]. (hindawi.com)
In the malignant tumor, deregulation of telomerase is thought to facilitate tumorigenesis and cellular immortality by providing cancer cells unlimited proliferation capacity. (nih.gov)
Is the Subject Area "Non-small cell lung cancer" applicable to this article? (plos.org)
As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. (nii.ac.jp)
In this treatment, we identified that CD44 is up-regulated under the hypoxia and this molecule supports stemness of cancer stem cells and induces drug resistance of cancer cells. (nii.ac.jp)
Journal Article] DNA damage enhanced by the attenuation of SLD5 delays cell cycle restoration in normal cells but not in cancer cells. (nii.ac.jp)
Lasp1 (LIM and SH3 domain protein 1) promotes tumor proliferation and invasion in multiple cancer entities including non-small cell lung cancer (NSCLC). (oncotarget.com)
Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer and accounts for approximately 40% of all lung cancer cases. (aging-us.com)
Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
Malignant mesothelioma is a type of cancer that starts in the linings of certain parts of the body, including the chest, abdomen, heart and testicles. (merck.com)
The miRNA profile between breast cancer stem cells(BCSCs, CD44+CD24-/low) and control MCF-7 breast cancer cells was obtained in a previous study. (researchsquare.com)
Then, agomir-20b-5p and antagomir-20b-5p were transfected into MCF-7 and T47D breast cancer cells to detect cell migration, wound healing and proliferation, and lentivirus vectors silencing or overexpressing miR-20b-5p were transfected into T47D-CSCs to detect proliferation and apoptosis. (researchsquare.com)
Oncogenic miR-20b-5p was confirmed to promote the malignant behaviors of breast cancer cells and BCSCs. (researchsquare.com)
Previous studies have confirmed that miRNAs play an important role in gene regulation in CD44 + CD24 -/low breast cancer stem cells (BCSCs). (researchsquare.com)
In our previous research, we performed miRNA profiling between sorted CD44 + CD24 -/low BCSCs and the control MCF-7 breast cancer cells [8]. (researchsquare.com)
Malignant mesothelioma is a difficult cancer to treat. (medlineplus.gov)
Mast cell tumors are the most common types of skin cancer tumors. (akc.org)
Mast cell tumors are cancer of these cells, and they can grow anywhere on your dog's skin, as well as in internal organs. (akc.org)
A new study has found that an intense form of ultrasound that shakes a tumor until its cells start to leak can launch an attack on cancer. (medindia.net)
There is not cured for MM. Tan II A has been reported to reduce cancer cell proliferation. (biomedcentral.com)
In esophageal cancer, radiation therapy was found inducing autophagy in cancer cells, promoting cancer cell proliferation and causing treatment resistance [ 10 ]. (biomedcentral.com)
Other reports suggested that autophage suppressed cancer development in early stage and promoted cancer cell proliferation in later stage [ 4 ]. (biomedcentral.com)
Most women with germ cell cancer will need to be treated with combination chemo for at least 3 cycles. (cancer.org)
Because of the estimated large volume, many cancer registries do not register basal cell skin cancer except for selected sites, such as skin of the external genital organs (for example, vulva, penis, scrotum). (cdc.gov)
An early cancer that is present only in the layer of cells in which it began. (cdc.gov)
B7-H4 is Inversely Correlated With T-Cell Infiltration in Clear Cell but Not Serous or Endometrioid Ovarian Cancer. (nih.gov)
For example, certain mutations associated with non small cell lung cancer are associated with beter outcomes. (northshore.org)
Cancer begins in your cells when the genetic material, or DNA, is damaged or changed. (cdc.gov)
In addition to its roles in the regulation of inflammatory diseases and the maintenance of local immune cells, CCL5 expressed by cancer cells plays diverse roles in shaping cancer microenvironments toward their own survival. (nature.com)
Other studies reported that some cancer cells could repress their own CCL5 expression to hinder migration of anticancer immune cells toward cancer sites 15 , 16 . (nature.com)
Therefore, host CCL5 can obviously work as an anticancer molecule to mount relevant immune responses against some cancer cells. (nature.com)
Therefore, it might be safe to say that host CCL5 plays important roles in controlling cancer development but might create either pro- or anticancer environments according to the given situation, such as the type of cells that produce CCL5 and the type of cancers. (nature.com)
RÉSUMÉ Des études en milieu hospitalier ont révélé des fréquences relatives très élevées du cancer oropharyngé au Yémen. (who.int)
Later, a different test found that the lump was a kind of cancer called a malignant peripheral nerve sheath tumor (MPNST), specifically a malignant triton tumor. (cdc.gov)

Chimeric antigen receptors (CAR) are fusion molecules that couple the HLA- independent binding of a selected cell surface target antigen to the delivery of a tailored T-cell activating signal. (aacrjournals.org)
These molecules are delivered to patient T-cells using retroviral gene-transfer, thereby stably re-directing their specificity for antigen. (aacrjournals.org)
Conclusion: This study highlights how prior methods that sequence whole tumor fractions (i.e. inclusive of alive/dead stromal cells) for antigen identification may have limitations. (cardiff.ac.uk)

Body cavity fluids (n = 600) received in our laboratory were processed according to a pre-designed protocol for the study as follows Day1 on receipt of the specimen, smears were made and a cell block was prepared from the sediment. (bvsalud.org)

Following our previous description of the serotonin transporter (SERT) acting as a conduit to 5-hydroxytryptamine (5-HT)-mediated apoptosis, specifically in Burkitt's lymphoma, we now detail its expression among a broad spectrum of B cell malignancy, while exploring additional SERT substrates for potential therapeutic activity. (erowid.org)

Other cytological features such as comet cells and cells with India ink nuclei are also helpful for diagnosis but have limited value because they are less frequently seen. (cytojournal.com)
Clot preparation from body cavity fluids on the second day can be used as an adjunct to smear and routine cell block preparation to improve the accuracy and yield of the cytological diagnosis and may also be of great help for special studies such as IHC staining . (bvsalud.org)

For example, miR-552 promotes cell proliferative rate of laryngocarcinoma cells by modulating p53 signaling [ 5 ]. (hindawi.com)
Journal Article] Cell-sheet Therapy With Omentopexy Promotes Arteriogenesis and Improves Coronary Circulation Physiology in Failing Heart. (nii.ac.jp)

instead, we found that PDGF-DD stimulated bulk tumor cell proliferation by induction of paracrine mitogenic signaling between heterogeneous malignant cell clones, some of which expressed PDGFRβ. (lu.se)

SERT was readily detected in derived B cell lines with origins as diverse as B cell precursor acute lymphoblastic leukemia, mantle cell lymphoma, diffuse large B cell lymphoma, and multiple myeloma. (erowid.org)
About 4% of cases of diffuse large B-cell cell lymphoma possess BCL2/MYC double translocations, suggesting a synergistic effect of BCL2 and MYC in lymphoma development. (haematologica.org)
8 - 12 Cases of CCND1/MYC double translocation are relatively frequent in mantle cell lymphoma. (haematologica.org)
Importantly, human B-cell lymphoma cases with concurrent multiple translocations including BCL2 , MYC and CCND1 have been reported. (haematologica.org)

To assess this phenomenon, we established tumor myofibroblasts cell line and analyzed the up-regulating genes in myofibroblasts upon exposure with hypoxia and/or serum starvation. (nii.ac.jp)
citation needed] There is mounting evidence that some individuals with malignant hyperthermia susceptibility may develop MH with exercise and/or on exposure to hot environments. (wikipedia.org)

MiR mimics could inhibit proliferative, invasive migratory rates while promoting apoptotic rates of M4E and Hep2 cells. (hindawi.com)
Recently, few studies revealed that miR-29a-3p could suppress the proliferative and invasive rates in laryngocarcinoma cells [ 10 , 11 ]. (hindawi.com)
Tan II A reduced CXCL12-induced A375 cell invasive ability and migration in a dose dependent manner. (biomedcentral.com)

According to the BrdU proliferation assay analysis, PCE demonstrated significant DNA synthesis inhibition of up to 80% at concentrations of 10, 50, 100 and 500 μg/ml in both cell lines. (iiarjournals.org)
PANX1 channel inhibition using probenecid (PBN) or carbenoxolone (CBX) reduced the proliferation of our panel of high-risk NB cell lines. (jcancer.org)

Napsin A is a specific marker for ovarian clear cell adenocarcinoma. (nih.gov)

Histologically, the tumor was composed of polygonal cells exhibiting diffuse hemorrhage, multifocal necroses, and vascular invasion. (nih.gov)

Due to the critical significance of early and accurate detection in improving the survival rate of a patient with a malignant granular cell tumor, an oncologist will order a number of diagnostic tests to produce rapid correct findings. (newhopemedicalcenter.com)

Recently, next-generation sequencing, especially single-cell RNA sequencing is a possible option for the analysis of detailed cell population subtypes of LUAD from bulk tissue samples at single cell level [ 10 , 11 ]. (aging-us.com)
The ability to rapidly and accurately discriminate between healthy and malignant tissue offers surgeons a tool for in vivo analysis that would potentially reduce operating time, facilitate quicker recovery, and improve patient outcomes. (mdpi.com)
Recent studies using neutralizing anti-CCL5 antibodies have suggested that the constitutive expression of CCL5 plays a regulatory role in maintaining tissue-resident memory (Trm) T cells in the human vaginal tract 9 and mouse skin 10 , suggesting that constitutive CCL5 expression in noninflamed conditions, hereafter referred to as homeostatic CCL5 expression, might be important for homeostasis of tissue-resident lymphocytes. (nature.com)

Malignant melanomas are most commonly found on the lips, mouth, and nail beds. (akc.org)
Malignant melanomas look like raised lumps, often ulcerated, and can also look like gray or pink lumps in the mouth. (akc.org)
Nail bed malignant melanomas, on the other hand, show up as toe swelling and possibly even loss of the toenail itself and destruction of underlying bone. (akc.org)

Smeere thought inadequate were those that had deteriorated or poorly preserved cell morphology, as well as extensive haemorrhage that obscured cellular features. (ganeshdiagnostic.com)

Design and Methods Growth in culture, colony formation and oncogenicity in vivo were assessed in mouse primary B cells exogenously expressing various combinations of Bcl2 , Myc and Ccnd1 . (haematologica.org)

Telomerase, an enzyme associated with cellular immortality, is expressed by malignant tumor and stem cells, especially germ cells. (nih.gov)
When the cell's DNA and protein damaged, the cells maintained its cellular homeostasis through autophagy. (biomedcentral.com)

While macrophages were reported to act as one of the cells in LUAD, enrichment analysis of macrophage marker genes revealed the important role of macrophages in the activation of neutrophils. (aging-us.com)

However, two conditions-synovial chondromatosis and tenosynovial giant cell tumors-occur in the lining (synovium) of joints. (msdmanuals.com)
Tenosynovial giant cell tumor (also known as pigmented villonodular synovitis [PVNS]) causes the lining of the joint to become swollen and grow. (msdmanuals.com)
Tenosynovial giant cell tumor usually affects one joint. (msdmanuals.com)

In fact, malignant hyperthermia susceptibility (MHS), predisposed by mutations in the skeletal muscle calcium release channel (RYR1), is one of the most severe heat-related illnesses. (wikipedia.org)
More than 25 different mutations in this gene are linked with malignant hyperthermia. (wikipedia.org)

We sought to explore the possible mechanism by which Tan II A regulated cell proliferation through autophagy signaling pathway in A375 cells. (biomedcentral.com)

These data suggest that topotecan needs to be administered in high concentrations, such as an intratumoral polymer, to limit glioma cell growth in synergy with CD95L in vivo . (aspetjournals.org)
The effect of miR-20b-5p on xenograft growth was investigated in vivo by transfection of a lentivirus-overexpression vector into T47D cells. (researchsquare.com)

Urine cytology for screening of transitional cell carcinoma (TCC) has been used for long time. (cytojournal.com)

The exosomes (Exo) from human bone marrow mesenchymal stem cells (hBMSCs) after the transfection of miR mimics/inhibitor/si-PTEN were isolated and used to stimulate M4E and Hep2 cells. (hindawi.com)

Malignant mesothelioma treatment (adult) (PDQ) -- Health professional version. (medlineplus.gov)

It is rare that malignant brain tumors occur in families. (northshore.org)
Any one of a group of diseases that occur when cells in the body become abnormal and grow or multiply out of control. (cdc.gov)

About 2-3% of all ovarian cancers are germ cell tumors. (cancer.org)
Germ cell cancers can raise blood levels of the tumor markers human chorionic gonadotropin (HCG), alpha-fetoprotein (AFP), and/or lactate dehydrogenase (LDH). (cancer.org)

Diseases4

Chemicals and Drugs2

Information Science1

Melanoma20

Benign11

Squamous7

Epithelial6

Including malignant glioma1

Vitro4

Glioma cells1

Symptoms of malignant1

Tumour3

Metastasis7

Patients13

Brain tumor4

Atypical12

Glioblastoma2

Cancerous3

Lymphomas6

Transformation3

Pathology2

Gliomas3

Chemotherapy2

Pleural3

Metastatic2

Induce1

Pathways1

Tumours1

Ovary1

Proliferation of stem cells1

Tissues5

Phenotypes2

Heterogeneity2

Disease3

Cancer39

Antigen3

Smears1

Apoptosis1

Diagnosis2

Promotes2

Clones1

Lymphoma4

Exposure2

Invasive3

Inhibition2

Adenocarcinoma1

Histologically1

Oncologist1

Tissue3

Melanomas3

Morphology1

Methods1

Cellular2

Enrichment1

Tenosynovial3

Mutations2

Regulated cell proliferation1

Vivo2

Cytology1

PTEN1

Mesothelioma1

Occur2

Cancers2