• Phosphorylation of Syk Activation Loop Tyrosines Is Essential for Syk Function. (crossref.org)
  • Phosphorylation of these residues provides docking sites necessary for downstream protein-protein interactions between BLNK and the SH2 domain-containing proteins Grb2, PLCG2, Btk, the Vav protein family, and Nck. (wikipedia.org)
  • Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. (wikipedia.org)
  • Moreover, mitogen-activated protein kinase, c-Jun N-terminal kinase, and p38 modulate Smad signals directly via Smad linker phosphorylation or indirectly via pathway crosstalk. (nih.gov)
  • Upon cytokine stimulation, STAT5 tyrosine phosphorylation (pYSTAT5) is transient, while in diverse neoplastic cells persistent overexpression and enhanced pYSTAT5 are frequently found. (nature.com)
  • We found that O-GlcNAcylation and tyrosine phosphorylation act together to trigger pYSTAT5 levels and oncogenic transcription in neoplastic cells. (nature.com)
  • Cytokine binding to the cell surface leads to phosphorylation of the receptor complex by receptor associated Janus kinases (JAKs) at tyrosine residues. (nature.com)
  • 7 The JAKs also trigger the activation and tyrosine phosphorylation of STAT5, causing parallel dimerization, nuclear translocation and tetramerization of STAT5. (nature.com)
  • Close Of course, we used p53 / p53 / and HCT116 wild-type cells.63 two roscovitine and CR8 were foreign Mcl a down-regulation sen, Also in theTat further stimulates the phosphorylation of RNA Pol II hyperphosphorylated. (micrornalibrary.com)
  • Antagonists such as FGF and EGF, and cellular Ren stress signals act through mitogen-activated protein kinases, phosphorylation of a region that induce DNA binding and Smad transcription bridged. (micrornalibrary.com)
  • The linker Smad-dependent cyclin is Independent kinases may need during the G1 cell cycle and MAPK phosphorylation by GSK3 action completed. (micrornalibrary.com)
  • The phosphorylation of Smad linker leads to the base line to their cytoplasmic retention and focused ligase, proteasome degradation with an accompanying reduction of the cellular Ren response to BMP and TGF-signals. (micrornalibrary.com)
  • Type I IFNs initiate their biological effects by binding to their transmembrane interferon receptors and initiating the phosphorylation and activation of tyrosine kinases TYK2 and JAK1, which promote phosphorylation and activation of STAT molecules. (scientificarchives.com)
  • Type I IFN-activated JAK1/TYK2 also induces rapid phosphorylation and activation of insulin receptor substrate 1 (IRS1) and 2 (IRS2), which subsequently bind to the catalytic p85 subunit of PI3K, which is required for the activation of the regulatory p110 subunit of PI3K [ 20 ]. (scientificarchives.com)
  • We demonstrate that TGF-β1 activates TGF-β1 receptors TGFBR1 and TGFBR2 resulting in ALK5-mediated phosphorylation of SMAD2. (springer.com)
  • TGF-β1 acts predominantly through phosphorylation of the C-terminal MH2 domains of SMAD2 and SMAD3 via activin receptor-like kinase 5 (ALK5), of which activity is located at the C-terminal part of TGFBR1. (springer.com)
  • Upon phosphorylation, R-SMADs recruit the co-SMAD SMAD-4 to form protein complexes that translocate into the nucleus and exhibit transcriptional activity. (springer.com)
  • tightly you dissipate your download, contribute the nursing of it, and bind in with your triphosphatase endocytosis promoter and bilayer pore( the activation Early occurs to the endocytic 4 products of your source phosphorylation). (evakoch.com)
  • While Akt Ser 473 phosphorylation was readily detectable in AND-34 +/+ lens epithelial cells, it was markedly reduced in the AND-34 −/− lens epithelium. (molvis.org)
  • These findings suggest that parasite proteins are able to inhibit erythroid cell growth by down-regulation of ezrin phosphorylation, leading to ineffective erythropoiesis ultimately resulting in severe malarial anaemia. (biomedcentral.com)
  • Many molecular pathways in eukaryotic cells are modulated by specific signaling proteins that are controlled, by phosphorylation and dephosphorylation, through the activity of kinase and phosphatase enzymes. (biomedcentral.com)
  • The level of protein phosphorylation at specific sites varies from less than 1% to greater than 90%, depending on conditions [ 26 ]. (biomedcentral.com)
  • supplied by OMIM] Evidence also suggests that BLNK may have tumor suppressive activity through its interaction with Bruton's tyrosine kinase (Btk) and regulation of the pre-B cell checkpoint. (wikipedia.org)
  • Evidence suggests that BLNK is phosphorylated by the tyrosine-protein kinase Syk after B cell receptor activation. (wikipedia.org)
  • Upon TGF binding to the respective TGF receptor, Smads2/3 are phosphorylated by the receptor kinase at the C-terminus, form a complex with Smad4 and translocate to the nucleus for activation of TGFbeta gene targets. (nih.gov)
  • GP (glycoprotein) VI activation of Magt1-/y platelets resulted in hyperphosphorylation of Syk (spleen tyrosine kinase), LAT (linker for activation of T cells), and PLC (phospholipase C) γ2, whereas the inhibitory loop regulated by PKC (protein kinase C) was impaired. (bvsalud.org)
  • In view of the importance that the checkpoint G1 / S in the viral replication plays, it is not surprising that HIV-1 proteins, Indeed, as has been shown that the activity t of G1 / S Our own studies, we observed the activity cyclin E/CDK2 kinase complexes, the t in HIV-infected cells of a fa erh ht Is latent because of the loss of natural CDK inhibitor p21/waf1. (micrornalibrary.com)
  • Non-canonical or alternative type I IFN signaling can activate additional pathways such as Crk-like protein (CrkL), the phosphatidyl-inositol 3-kinase (PI3K) pathway, and the mitogen-activated protein kinase (MAPK) pathway [ 15 ]. (scientificarchives.com)
  • Conversely, inhibition of PVA neuronal activity using DREADDs (designer receptors exclusively activated by designer drugs) or inactivation of PVA extracellular signal-regulated kinase at the critical time window blunted mechanical hyperalgesia in chronic pain models. (iasp-pain.org)
  • transiting of such constituent c receptor type VIa regions in kinase during activation. (evakoch.com)
  • Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)
  • Physiologically, the N-terminal domain of p126 binds the Src-homology 3 (SH3) domain of c-Abl, leading to activation of the MAPK/ERK2 kinase. (molcells.org)
  • In the 2D3, the precise TCR functional avidity of transduced TCRs is easily evaluable by the expression of green fluorescent protein (GFP) reporter gene driven by nuclear factor of activated T cells (NFAT) activation via TCR signaling. (oncotarget.com)
  • Four different TCRs of HLA-A * 24:02-restricted Wilms' tumor gene 1 (WT1)-specific CD8 + cytotoxic T lymphocytes (CTLs) were transduced into 2D3 cells and the functional avidities of these four TCRs were evaluated. (oncotarget.com)
  • These preclinical and clinical evidences encourage us to develop T-cell adoptive immunotherapy using genetically engineered T cells that are transduced with a T-cell receptor (TCR) gene specific for TAA. (oncotarget.com)
  • Figure 1: Summary of estrogen receptor and RNA PolII binding sites and correlation with nucleotide and gene number. (nature.com)
  • Figure 3: Estrogen receptor and RNA PolII binding relative to specific gene targets. (nature.com)
  • In the version of this article initially published online, the estrogen receptor and RNA PolII binding data were aligned incorrectly in the top panel of Figure 3, which represents estrogen receptor binding at the ESR1 gene region. (nature.com)
  • An estimated 90% of patients with early-onset agammaglobulinemia and absence of B cells have abnormalities in the Btk gene (ie, Bruton agammaglobulinemia or XLA). (medscape.com)
  • Activated STAT1 and STAT2 monomers dimerize and interact with IRF9 (IFN-regulatory factor 9) in the cytoplasm, which is known as the ISGF3 (IFN-stimulated gene (ISG) factor 3) complex [ 1 , 7 ]. (scientificarchives.com)
  • B) Luciferase reporter gene detection in ZR75-1 and MDA-MB-231 breast cancer cells co-transfected with expression in ZR75-1 and MDA-MB-231 cells, which were transfected with ZKSCAN5 shRNA, control shRNA, or ZKSCAN5 shRNA plus shRNA-resistant ZKSCAN5 (ZKSCAN5-R). The representative Western blot further showed the expression of ZKSCAN5. (bms-911543.com)
  • The defect of µ heavy-chain gene on chromosome 14 is the most frequent abnormality in patients with agammaglobulinemia and decreased B cells but no defect in Btk. (medscape.com)
  • Smac (Second mitochondria-derived activator of caspase) protein, also known as DIABLO (Direct Inhibitor of Apoptosis-Binding protein with LOw pI), is codified by a nuclear gene. (biomedcentral.com)
  • In a microarray approach, we found the suppression of tumorigenicity 5 (ST5) gene is upregulated by receptor activator of nuclear factor-κB ligand (RANKL), the OC differentiation factor. (molcells.org)
  • 2005 This possibility was supported by a recent study using lineage-specific conditional deletion of gene expression which identified presentation by different types of antigen-presenting cells (APCs) as a major factor underlying the cytokine biasing properties of different αGC variants (Bai et?al. (biotech-angels.com)
  • immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
  • The evaluated functional avidity of these TCRs positively correlated with cell proliferation, cytokine production, and WT1-specific cytotoxicity of the TCR-transduced CD8 + T cells in response to WT1 antigen. (oncotarget.com)
  • The signal transducer and activator of transcription 5 (STAT5) regulates differentiation, survival, proliferation and transformation of hematopoietic cells. (nature.com)
  • Antineoplastic agents inhibit cell growth and proliferation. (medscape.com)
  • Platinum compounds inhibit cell growth and proliferation. (medscape.com)
  • The interaction of TNFRSF9 and its ligand, TNFSF9, leads to the activation of cytotoxic T cells, reactivation of anergic T lymphocytes, and induces T-cell proliferation. (biolegend.com)
  • The type I IFN-induced CrkL pathway is critical for the proliferation of both hematopoietic and non-hematopoietic cells. (scientificarchives.com)
  • It is believed that TGF-β1 signalling is involved in controlling epithelial cell proliferation, to drive epithelial-mesenchymal transition (EMT) and it plays a major role in lung fibrosis and emphysema. (springer.com)
  • Cancer cells demand high energy production to sustain their pathological increase in proliferation rate. (hindawi.com)
  • ZKSCAN5-Regulated VEGFC Promotes the Proliferation, Migration, and Tube Formation of HLECs Cancer cell-secreted VEGFC markedly enhanced the proliferation and migration of lymphocyte endothelial cells. (bms-911543.com)
  • Because ZKSCAN5 improved the secretion of VEGFC by breast cancer cells, the effects of the conditioned medium on HLEC proliferation and migration were investigated in ZKSCAN5 knockdown stable cell lines. (bms-911543.com)
  • The ZKSCAN5 knockdown ZR75-1 or MDA-MB-231 cell-conditioned medium decreased HLEC proliferation. (bms-911543.com)
  • The conditioned medium from these cells re-expressing ZKSCAN5 could rescue these effects ( Figures?2A, B ). A similar tendency was also detected in HLEC migration analysis ( Figures?2C, D ). Open in a separate window Figure?2 VEGFC secreted by cancer cells, under the influence of ZKSCAN5, regulates HLEC proliferation, migration, and tube formation. (bms-911543.com)
  • A, B) Cell proliferation and colony formation assays in HLECs cultured in conditioned medium come from ZR75-1 or MDA-MB-231 cells stably infected with lentivirus carrying ZKSCAN5 shRNA or ZKSCAN5 shRNA plus ZKSCAN5-R. The representative Western blot displays the expression of ZKSCAN5. (bms-911543.com)
  • T cells stimulate B cells to undergo further proliferation and Ig class switching, leading to the expression of the various isotypes IgG, IgA, or immunoglobulin E (IgE). (medscape.com)
  • In previously reports , Plasmodium vivax was found to be able to directly inhibited erythroid cell proliferation and differentiation. (biomedcentral.com)
  • Moreover, in vitro cultures of erythroid cells derived from haematopoietic stem cells has demonstrated that P. vivax is able to directly inhibit erythroid cell proliferation and differentiation [ 22 ]. (biomedcentral.com)
  • Second, T cell receptor (TCR)-mediated intracellular signals are sufficient to induce ezrin relocalization, indicating that this protein is an effector of TCR signaling. (ox.ac.uk)
  • Thus, activated, type I subunits recruit and phosphorylate receptor SMADs (R-smad), which are the first intracellular mediators of TGF-β signalling. (springer.com)
  • 2011 In contrast glycolipids that induce responses that are biased toward Th1 cell cytokines are more hydrophobic and require intracellular loading onto CD1d for presentation (Arora et?al. (biotech-angels.com)
  • To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Smads2/3 are key signaling molecules downstream of cell surface receptors for TGFbeta or activin. (nih.gov)
  • 15 The dynamic addition and removal of O-GlcNAc has been described for multiple cytoplasmic and nuclear proteins and it affects the function of various signaling molecules and transcription factors. (nature.com)
  • Gimferrer I, Farnós M, Calvo M, Mittelbrunn M, Enrich C, Sánchez-Madrid F, Vives J, Lozano F. The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells. (hcdm.org)
  • HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)
  • Our platform provides a range of small molecules , antibodies , and proteins . (enzolifesciences.com)
  • It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). (embl.de)
  • 2011 A unifying feature of αGC analogs that induce predominantly Th2 cell-associated cytokines is that they are more polar than KRN7000 and can load directly onto CD1d molecules on the cell surface (Im et?al. (biotech-angels.com)
  • 2012 However other studies yielded different conclusions identifying pharmacokinetic properties of the glycolipids or localization of CD1d molecules containing bound glycolipids to different membrane microdomains as major determinants of cytokine skewing in the response to iNKT cell activation (Im et?al. (biotech-angels.com)
  • Interaction of CD8α+ dendritic cells (DCs) with iNKT cells during presentation of Th1 cell-biasing versus Th2 cell-biasing glycolipid antigens led to markedly different changes in expression of costimulatory and coinhibitory molecules on these. (biotech-angels.com)
  • Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. (hcdm.org)
  • Ligand strand is a next activation in NOTCH3, which is the damaged response in the synaptogenic potential of NOTCH3. (evakoch.com)
  • Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism. (neurotree.org)
  • Adoptive T-cell therapy with T cell receptor (TCR) -engineered T cells is an attractive strategy for cancer treatment and the success in this therapy is dependent on the functional avidity of the transduced TCRs against targeted tumor antigens. (oncotarget.com)
  • Adoptive immunotherapy using tumor-associated antigen (TAA)-specific CD8 + cytotoxic T lymphocytes (CTLs) and/or CD4 + helper T (Th) cells can induce the regression of large established tumor in not only mouse models but also cancer patients [ 1 - 3 ]. (oncotarget.com)
  • 5-FU inhibits tumor cell growth through at least 3 different mechanisms that ultimately disrupt DNA synthesis or cellular viability. (medscape.com)
  • TNFRSF9, also known as 4-1BB and CD137, is a member of the tumor necrosis factor receptor superfamily (TNFRSF). (biolegend.com)
  • OA onset results in the upregulation of several inflammatory cytokines including interleukin 1 (IL-1) and tumor necrosis factor-alpha (TNF-α) which in turn upregulate the expression of proteolytic enzymes that break down the cartilage matrix [ 3 , 4 ]. (biomedcentral.com)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • Tumor cells are subjected to stressful internal and external environments, but nevertheless are resistant to apoptosis. (biomedcentral.com)
  • Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. (wikipedia.org)
  • 2012 Studies of the prototypical glycolipid antigen of iNKT cells an α-galactosylceramide (αGC) known as KRN7000 show the potential for iNKT cells to KM 11060 activate a range of immune effector functions in?vivo. (biotech-angels.com)
  • BLNK is essential for normal B-cell development as part of the B cell receptor signaling pathway. (wikipedia.org)
  • These ATG proteins also perform an important parallel role in 'noncanonical' autophagy, a lysosome-associated signaling pathway with key functions in immunity, inflammation, cancer, and neurodegeneration. (babraham.ac.uk)
  • Here, we review the diverse, and still expanding, collection of stimuli and processes now known to harness the noncanonical autophagy pathway, including engulfment processes, drug treatments, TRPML1 and STING signaling, viral infection, and other pathogenic factors. (babraham.ac.uk)
  • Apoptosis can be activated through two pathways: The extrinsic pathway (mediated by death receptors) or the intrinsic pathway (mediated by mitochondria). (biomedcentral.com)
  • The intrinsic pathway is induced by several different stimuli like antineoplastic drugs, hypoxia, irradiation, growth factor withdrawal and heat shock. (biomedcentral.com)
  • However, whether hinokitiol can restore normal iron physiology in FPN1-deficient animals or primary cells from patients and the mechanisms underlying such targeted activities remain unknown. (bvsalud.org)
  • Structures of Ric-8B in complex with Galpha protein folding clients reveal isoform specificity mechanisms. (stanford.edu)
  • The group is dedicated to research in Immunology, with special emphasis on the development of chimeric antigen receptors (CAR) for cellular immunotherapy and on the study of early signaling mechanisms and the mechanisms involved in the induction of immunological tolerance. (inibica.es)
  • The maintenance of the steady-state equilibrium between ROS generation and elimination is crucial for cell survival, while its loss causes cell death by different mechanisms triggered by oxidative damage. (hindawi.com)
  • Angiogenesis depends on both cell adhesion and proteolytic mechanisms. (embl.de)
  • Like all adaptor proteins, BLNK has no known intrinsic enzymatic activity. (wikipedia.org)
  • SLP-76 7 , T cell-specific adaptor protein 8 , TCR/CD3 complex 9 and Syntenin-1. (hcdm.org)
  • Hem CD, Ekornhol M, Granum S, Sundvold-Gjerstad V, Spurkland A. CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein. (hcdm.org)
  • AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. (molvis.org)
  • 3 STAT5 regulated signaling controls important functions of innate and acquired immunity, hematopoiesis, and also growth and survival of many cell types in different organs responding to extracellular cytokines. (nature.com)
  • Adhesion G-protein-coupled receptors (aGPCRs) are characterized by the presence of auto-proteolysing extracellular regions that are involved in cell-cell and cell-extracellular matrix interactions1. (stanford.edu)
  • Low-resolution maps of the receptors in their N-terminal fragment-bound state indicate that the GAIN domain projects flexibly towards the extracellular space, keeping the encrypted TA peptide away from the seven-transmembrane domain. (stanford.edu)
  • High-resolution structures of GPR56 and LPHN3 in their active, G-protein-coupled states, reveal that after dissociation of the extracellular region, the decrypted TA peptides engage the seven-transmembrane domain core with a notable conservation of interactions that also involve extracellular loop 2. (stanford.edu)
  • 1 Its extracellular region contains 3 scavenger receptor cysteine-rich domains. (hcdm.org)
  • MiRNAs are abundant in many mammalian cell types and as extracellular circulating miRNAs. (micrornalibrary.com)
  • The leucine zipper motif allows BLNK to localize to the plasma membrane, presumably by coiled-coil interactions with a membrane protein. (wikipedia.org)
  • Recruitment of BLNK to the plasma membrane is also achieved by binding of the SH2 domain of BLNK to a non-ITAM phospho-tyrosine on the cytoplasmic domain of CD79A, which is a part of Igα and the B cell receptor complex. (wikipedia.org)
  • The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation. (ox.ac.uk)
  • Dynamic interactions between membrane and cytoskeleton components are crucial for T cell antigen recognition and subsequent cellular activation. (ox.ac.uk)
  • We report here that the membrane-microfilament linker ezrin plays an important role in these processes. (ox.ac.uk)
  • First, ezrin relocalizes to the contact area between T cells and stimulatory antigen-presenting cells (APCs), accumulating in F-actin-rich membrane protrusions at the periphery of the immunological synapse. (ox.ac.uk)
  • Third, overexpression of the membrane binding domain of ezrin perturbs T cell receptor clustering in the T cell-APC contact area and inhibits the activation of nuclear factor for activated T cells (NF-AT). (ox.ac.uk)
  • Cryogenic electron microscopy (cryo-EM) has widened the field of structure-based drug discovery by allowing for routine determination of membrane protein structures previously intractable. (stanford.edu)
  • Despite representing one of the largest classes of therapeutic targets, most inactive-state G protein-coupled receptors (GPCRs) have remained inaccessible for cryo-EM because their small size and membrane-embedded nature impedes projection alignment for high-resolution map reconstructions. (stanford.edu)
  • Recent work published in The EMBO Journal and EMBO Reports reveals a novel role for the protein TECPR1 as a sensor for stressed membranes and regulator of lysosomal membrane repair. (babraham.ac.uk)
  • However, the Atg8 family of proteins are not found solely attached to double-membrane autophagosomes. (babraham.ac.uk)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • Fundamentally based on the development of Chimeric Antigen Receptors (CAR), with application in oncological and inflammatory diseases (cardiovascular, digestive, neurological, etc.) and in rejection of transplanted organs. (inibica.es)
  • Oxidative stress produces DNA damage and also induces responses, which could help the cell to restore the initial equilibrium. (hindawi.com)
  • This in turn induces the recruitment of adapter proteins (FADD, TRADD o RAIDD) to form the so-called death-inducing signal complex (DISC), which activates caspase-8. (biomedcentral.com)
  • 2005 On the other hand replacing the O-glycosidic linkage of αGC with a nonhydrolyzable carbon linker gives a C-glycoside variant that induces cytokine responses biased toward cytokines characteristic of T helper 1 (Th1) cells along with enhanced transactivation of NK cells and their secretion of interferon-γ (IFN-γ) (Schmieg et?al. (biotech-angels.com)
  • Deficiencies of the transmembrane iron-transporting protein ferroportin (FPN1) cause the iron misdistribution that underlies ferroportin disease, anemia of inflammation, and several other human diseases and conditions. (bvsalud.org)
  • A small molecule natural product, hinokitiol, was recently shown to serve as a surrogate transmembrane iron transporter that can restore hemoglobinization in zebrafish deficient in other iron transporting proteins and can increase gut iron absorption in FPN1-deficient flatiron mice. (bvsalud.org)
  • TA binding stabilizes breaks in the middle of transmembrane helices 6 and 7 that facilitate aGPCR coupling and activation of heterotrimeric G proteins. (stanford.edu)
  • CD6 is a type 1 transmembrane glycoprotein belonging to the scavenger receptor cysteine-rich family. (hcdm.org)
  • Studies have shown that all type I IFNs exclusively bind to and signal through ubiquitously expressed heterodimeric transmembrane (TM) receptors composed of two subunits-IFNAR1 and IFNAR2 [ 3 ], which are constitutively associated with tyrosine kinases TYK2 and JAK1/STAT2 (signal transducer and activator of transcription 2), respectively, under normal physiological conditions [ 4 , 5 ]. (scientificarchives.com)
  • Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2. (cdc.gov)
  • Arsenic activates nuclear factor erythroid 2-related factor 2 (Nrf2) to induce phase II and antioxidative genes. (cdc.gov)
  • however, nuclear accumulations of pSMAD2-C and CLDN3 redistribution were observed with similar time course in ciliated and non-ciliated cells. (springer.com)
  • D) Cytoplasmic and nuclear ZKSCAN5 protein levels in two types of breast cancer cell lines, ZR75-1 and MDA-MB-231. (bms-911543.com)
  • Tubulin was used as the cytoplasmic control, and lamin A/C was used as the nuclear protein-loading control. (bms-911543.com)
  • Finally, these signaling pathways induce expression of the nuclear factor of activated T cells c1 (NFATc1), which is a key transcription factor for osteoclastogenesis. (molcells.org)
  • Calcium signaling is known to play a role in NFATc1 activation by promoting its nuclear translocation. (molcells.org)
  • O-GlcNAcylation of STAT5 could be required for nutrient sensing and metabolism of cancer cells. (nature.com)
  • 16 Cancer cells exhibit elevated levels of O-GlcNAc, possibly to adjust to stringent metabolic demands and O-GlcNAcylation is a key metabolic regulator of glucose metabolism. (nature.com)
  • Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
  • Treatment with a single dose of CPC-IGF-1 effectively suppressed IL-1α-induced GAG loss and nitrite release and rescued cell metabolism and viability throughout the 16-day culture period, while free IGF at the equivalent dose was not effective. (biomedcentral.com)
  • Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. (neurotree.org)
  • We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. (nature.com)
  • Early stages of B-cell differentiation can be identified by the status of the immunoglobulin genes and by the cell surface markers CD34, CD19, and surface immunoglobulin (sIg). (medscape.com)
  • Genes required for B cell development. (medscape.com)
  • These cells develop into late pro-B cells in which rearrangement of the heavy chain genes occurs. (medscape.com)
  • This rearrangement process requires the recombination activating genes RAG1 and RAG2, which are controlled by IL-7 and perhaps other factors. (medscape.com)
  • Progression from this late pro-B-cell to the pre-B-cell stage involves the rearrangement and joining of the various segments of the heavy chain genes. (medscape.com)
  • This ISGF3 complex translocates to the nucleus, binds IFN-stimulated response elements (ISREs) in DNA, and initiates the activation of several hundred interferon stimulated genes (ISGs) [ 8 , 9 ]. (scientificarchives.com)
  • Type I IFN- activated STAT1 can also form a homodimer known as IFNγ-Activated Factor (GAF), which migrates into the nucleus, and binds to IFNγ-Activated Sequences (GAS), to induce proinflammatory genes [ 10 , 11 ]. (scientificarchives.com)
  • Using a method of genetic amplification involving the poly- merase enzyme, they multiplied the number of genes of the alpha-subunits of several G-proteins, notably gustducin, which is uniquely expressed in such papillary cells. (forexsignalx.com)
  • A) Luciferase reporter genes were determined in ZR75-1 and MDA-MB-231 breast cancer cells co-transfected with Glutaminase-IN-1 different concentrations of reporter and myc-ZKSCAN5. (bms-911543.com)
  • Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
  • Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. (nature.com)
  • CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. (hcdm.org)
  • However, factors associated with non-canonical ATG16L1 recruitment and CASM induction remain unknown. (babraham.ac.uk)
  • The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment. (babraham.ac.uk)
  • We have shown that this process is triggered by recruitment of ATG16L1 by the vacuolar-type H-translocating ATPase (V-ATPase) proton pump, suggesting a role for pH sensing in recruitment of Atg8-family proteins to single membranes. (babraham.ac.uk)
  • Consequently, the recruitment of immune cells during chronic inflammation increases oxidative stress (OS) in the microenvironment [ 2 ]. (hindawi.com)
  • The platinum complex also can bind to nucleus and cytoplasmic protein. (medscape.com)
  • Transforming growth factor beta (TGFbeta), a multifunctional growth factor, is one of the most important ligands involved in the regulation of cell behavior in ocular tissues in physiological or pathological processes of development or tissue repair, although various other growth factors are also involved. (nih.gov)
  • on-resin cyclization of peptide ligands of the vascular endothelial growth factor receptor 1, etc. (genengnews.com)
  • The former is activated in response to the engagement of ligands such as CD95 or TNF-α with their receptors. (biomedcentral.com)
  • Here we analyzed arsenic - Kelch-like ECH-associated protein 1 (Keap1) cysteine thiol interaction in Nrf2 activation. (cdc.gov)
  • In vivo studies with TNFSF9 knockout mice and with the agonistic anti-TNFRSF9 monoclonal antibody showed that TNFRSF9/TNFSF9 interaction keeps optimal CD8 T-cell mediated immune response against viral infections and tumors. (biolegend.com)
  • This occurs through specific modulation of regulatory proteins during the host-pathogen interaction, especially proteins with roles in pathogenesis [ 27 ]. (biomedcentral.com)
  • cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)
  • Graphical Abstract Introduction Natural killer T?cells with invariant T?cell receptor α chains (iNKT cells) are a conserved population that recognizes KM 11060 glycolipid antigens bound to CD1d a lipid antigen-presenting molecule with structural similarities to major histocompatibility complex (MHC) class I proteins (Brennan et?al. (biotech-angels.com)
  • Aruffo A, Melnick MB, Linsley PS, Seed B. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. (hcdm.org)
  • Martínez-Florensa M, Consuegra-Fernández M, Martínez VG, Cañadas O, Armiger-Borràs N, Bonet-Roselló L, Farrán A, Vila J, Casals C, Lozano F. Targeting of key pathogenic factors from gram-positive bacteria by the soluble ectodomain of the scavenger-like lymphocyte receptor CD6. (hcdm.org)
  • lymphocyte cytosolic protein 2 (SH2 domain. (wikigenes.org)
  • B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
  • Therefore, it is not surprising that GI disorders are common manifestations, and often the initial presenting symptom, in patients with dysfunction in humoral immunity or cell-mediated immunity ( Table 1 ). (medscape.com)
  • Type I interferons (IFNs) produced in response to infections with either bacterial, viral or fungal pathogens are critical to induce antimicrobial defenses in infected and adjacent cells to reduce the spread of microbes, initiate communication between innate and adaptive immunity, and to promote the survival of the host [ 1 ]. (scientificarchives.com)
  • 1 Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan. (jci.org)
  • Mammalian Ric-8 proteins act as chaperones to regulate the cellular abundance of heterotrimeric G protein alpha subunits. (stanford.edu)
  • This triggered an increase in paracellular permeability via cellular redistribution of claudin 3 (CLDN3) from TJs into cell nuclei followed by disruption of epithelial integrity and formation of epithelial lesions. (springer.com)
  • These are as follows: sustained proliferative signalling, cell death resistance, replicative immortality, genome instability and increased mutations, tumour-promoted inflammation, insensibility to growth repressors, deregulation of cellular energetics, evasion of immune destruction, induction of metastasis, and promotion of angiogenesis. (hindawi.com)
  • All of the disease-causing ACTN4 mutations identified to date are located within the actin-binding domain of the encoded protein, increasing its binding affinity to F-actin and leading to abnormal actin rich cellular aggregates. (biomedcentral.com)
  • This protein family is comprised by X-linked inhibitor of apoptosis (XIAP), cellular IAP-1 (c-IAP1), cellular IAP-2 (c-IAP2), Testis specific IAP (Ts-IAP), survivin, livin and BRUCE/Apollon [ 8 ]. (biomedcentral.com)
  • These proteins display interactions and are involved in the regulation of the cellular cytoskeleton. (biomedcentral.com)
  • B-cell linker (BLNK) protein is expressed in B cells and macrophages and plays a large role in B cell receptor signaling. (wikipedia.org)
  • Its function is to temporally and spatially coordinate and regulate downstream signaling effectors in B cell receptor (BCR) signaling, which is important in B cell development. (wikipedia.org)
  • This leucine zipper motif distinguishes BLNK from lymphoctye cytosolic protein 2, also known as LCP-2 or SLP-76, which plays a similar role in T cell receptor signaling. (wikipedia.org)
  • Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. (upm.edu.my)
  • Furthermore, this resource has allowed the identification of cis -regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer. (nature.com)
  • Although activated TYK2 and JAK1 phosphorylate and activate STAT2, which is a critical early step for STAT1 activation by type I IFN in canonical signaling [ 6 ], the mechanism of STAT2-dependent STAT1 activation after stimulation of type I IFN is poorly understood. (scientificarchives.com)
  • Prior data link AND-34 expression to the activation of Akt signaling. (molvis.org)
  • These results demonstrate the loss of AND-34 dysregulates focal adhesion complex signaling in lens epithelial cells and suggest that AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens. (molvis.org)
  • These studies have served to highlight the role of AND-34/BCAR3 and p130Cas in cell adhesion and migration signaling pathways. (molvis.org)
  • Identification of the first marine-derived opioid receptor "balanced" agonist with a signaling profile that resembles the endorphins. (neurotree.org)
  • Goldsmith JR, Perez-Chanona E, Yadav PN , Whistler J , Roth B , Jobin C. Intestinal epithelial cell-derived μ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling. (neurotree.org)
  • Our outcomes claim that activation of Erk1/2, p38, and JNK pathways is one of the signaling cascades that mediate the upregulation of COX-2 appearance and PGE2 creation in individual chondrocytes subjected to proinflammatory cytokine IL-1 .05. (californiaehealth.org)
  • Studies from our laboratory have shown that an HIV-infected T-cells of F Latent expression of p21/waf1 is not to breach the host cell They induce. (micrornalibrary.com)
  • Direct activation of PVA neurons using optogenetics and pharmacological approaches were sufficient to induce persistent mechanical hyperalgesia in naive animals. (iasp-pain.org)
  • As a result, activation of right central nucleus of amygdala with blue light was enough to induce persistent mechanical hyperalgesia. (iasp-pain.org)
  • Commonly used radio- and chemotherapies are prooxidant strategies that alter cancer cells through ROS modulation and induce cell death [ 5 , 6 ]. (hindawi.com)
  • 2008 Multiple studies show that this transactivation is influenced by the precise structure of glycolipid antigens which has enabled manipulation of immune responses with structural analogs of αGC (Venkataswamy and Porcelli 2010 For example derivatives of αGC containing truncated or unsaturated N-acyl chains induce responses in which cytokines typically associated with T helper-2 (Th2) cells predominate KM 11060 and transactivation of NK cells is limited (Yu et?al. (biotech-angels.com)
  • Supplementation of MgCl2 or pharmacological blockade of TRPC6 (transient receptor potential cation channel, subfamily C, member 6) channel, but not inhibition of store-operated calcium entry, normalized the aggregation responses of Magt1-/y platelets to the control level. (bvsalud.org)
  • The library is ideal for screening or identifying recombinant orphan G protein-coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. (enzolifesciences.com)
  • Pharmacological and genetic manipulations at the µ-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice. (neurotree.org)
  • Pharmacological traits of delta opioid receptors: pitfalls or opportunities? (neurotree.org)
  • DT40 cells had interrupted B cell development: there was no calcium mobilization response in the B cell, impaired activation of the mitogen-activated protein (MAP) kinases p38, JNK, and somewhat inhibited ERK activation upon (BCR) activation as compared to wild type DT40 cells. (wikipedia.org)
  • Upon binding of type I IFNs to IFNAR1 and IFNAR2, the proximal receptor complex is assembled and the tyrosine kinases TYK2 and JAK1 are activated by reciprocal transphosphorylation. (scientificarchives.com)
  • With previously results using major articular chondrocytes [17 Regularly, 18], our outcomes present that IL-1 em /em causes an instant activation of JNK, p38, and Erk1/2 MAP kinases in immortalized Loganic acid individual T/C28a2 chondrocytes. (californiaehealth.org)
  • The structural and functional basis of cytokine receptor acti- vation: Lessons from the common beta subunit of the granulocyte-macrophage-colony-stimulating factor, interleukin-3 and interleukin-5 receptors. (forexsignalx.com)
  • By visualizing glycolipid antigen presentation directly with monoclonal antibodies specific for complexes of αGC bound to CD1d we showed that the CD8α+DEC-205+ subset of dendritic cells was the major APC in the spleen for a range of αGC analogs irrespective of their chemical structures and cytokine biasing activities. (biotech-angels.com)
  • The mucosal immune system is uniquely regulated to manage its constant exposure to viruses, parasites, and bacterial antigens, all of which are in close proximity to a large reservoir of lymphocytes, macrophages, and dendritic cells. (medscape.com)
  • CD6 is expressed in T cells 1 , medullary thymocytes 1 , a subset of NK cells 2 , some hematopoietic progenitors 3 and a small group of B lymphocytes. (hcdm.org)
  • GM-CSF down-regulates inhibited by factors( T-lymphocytes, mouse heterotrimers, necessary phosphatidylinositol, p46 acids) estimated at acids of intrinsic tissues. (evakoch.com)
  • The tethered peptide activation mechanism of adhesion GPCRs. (stanford.edu)
  • All members of transforming growth factor superfamily are synthesized as pre-pro-peptides that consist of a short N-terminal signalling peptide, a latency-associated protein (LAP) domain and the mature TGF domain [ 42 ]. (springer.com)
  • Human adiponectin (aa 16-244) is fused at the N-terminus to a linker peptide (14 aa) and a FLAG ® -tag. (enzolifesciences.com)
  • Metabolically active cells, neutrophils, and macrophages from the immune system produce high levels of ROS. (hindawi.com)
  • 2021) Functional diversification gave rise to allelic specialization in a rice NLR immune receptor pair. (oeaw.ac.at)
  • This type of cell death is fundamental for the maintenance of tissue homeostasis and immune system development [ 2 ]. (biomedcentral.com)
  • A more recent mass spectrometry study of BLNK in DT40 cells found that at least 41 unique serine, threonine, and tyrosine residues are phosphorylated on BLNK. (wikipedia.org)
  • OGT transfers O-GlcNAc moieties from UDP-GlcNAc to serine and threonine residues of proteins and O-GlcNAcase (OGA) catalyzes the opposite reaction to remove O-GlcNAc. (nature.com)
  • These gamma-secretase proteins have interference end-joining Formation, module topology and domain. (evakoch.com)
  • VEGF-D (E, F) Tube formation assays for HLECs cultured in the conditioned medium from ZR75-1 or MDA-MB-231 cells, which were stably infected as in (A). All values shown are the mean SD of triplicate measurements and were repeated three times with analogous. (bms-911543.com)
  • Osteoclastogenesis is a multi-step process including commitment of OC precursor cells to mononucleated preosteoclasts (pOCs), fusion for formation of multinucleated OCs, and maturation of OCs for bone resorption activity. (molcells.org)
  • Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor dependence. (molvis.org)
  • Levels of PEX in these vascularized tissues suggest that it interacts with endothelial cell alphavbeta3 where it serves as a natural inhibitor of MMP-2 activity, thereby regulating the invasive behavior of new blood vessels. (embl.de)
  • In the cytosol, Smac/DIABLO interacts and antagonizes inhibitors of apoptosis proteins (IAPs), thus allowing the activation of caspases and apoptosis. (biomedcentral.com)
  • A particle according to claim 1 or 2, wherein the heterologous polypeptide has specific binding affinity for a cognate receptor on die surface of an eukaryotic cell, binding to which does not allow infection of the cell by the viral particle. (sumobrain.com)
  • A particle according to claim 1 or 2, wherein the heterologous polypeptide has no specific binding affinity for a eukaryotic cell surface component. (sumobrain.com)
  • A particle according to any one of the preceding claims, wherein the heterologous polypeptide sterically hinders binding of d e viral glycoprotein to its cognate receptor on the eukaryotic cell. (sumobrain.com)
  • A particle according to any one of the preceding claims, wherein heterologous polypeptide sterically hinders fusion of an enveloped viral particle with an eukaryotic cell to which it is bound. (sumobrain.com)
  • A particle according to any one of the preceding claims, wherein the protease cleavage site is accessible to the relevant protease (i.e. that which recognises the cleavage site) before the viral particle becomes bound to an eukaryotic cell. (sumobrain.com)
  • A particle according to any one of claims 1 to 9, wherein the protease cleavage site becomes accessible to die relevant protease only after the viral particle has become bound to an eukaryotic cell. (sumobrain.com)
  • A particle acording to claim 11 , wherein the protease cleavage site becomes accessible after the heterologous polypeptide has bound to its cognate receptor on the eukaryotic cell. (sumobrain.com)
  • The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. (nature.com)
  • 2021) Principles of mRNA targeting and regulation via the Arabidopsis m6A-binding proteins ECT2 and ECT3. (oeaw.ac.at)
  • 2021) Cdc4 phospho-degrons allow differential regulation of Ame1CENP-U protein stability across the cell cycle. (oeaw.ac.at)
  • In this study, a phosphoproteomic approach was performed to dissect the molecular mechanism of phosphoprotein regulation, which is involved in the inhibitory effect of parasites on erythroid cell development. (biomedcentral.com)
  • This result suggests that phospho-ezrin is important for actin cytoskeleton regulation during erythroid cell growth and division. (biomedcentral.com)
  • SP600125 didn't downregulate IL-1-induced COX-2 mRNA appearance when assessed 2?h after addition of IL-1but suppressed mRNA amounts in the afterwards period factors suggesting post-transcriptional regulation. (californiaehealth.org)
  • But if this is not possible, oxidative stress finally activates signals that will lead to cell death. (hindawi.com)
  • As part of its charge, the committee was asked to prepare a subreport evaluating methods for detecting potential unintended compositional changes across the spectrum of messenger ribonucleic acid (mRNA), proteins, metabolites and nutrients that may occur in food derived from cloned animals that have not been genetically modified via genetic engineering methods. (nationalacademies.org)
  • 2021) The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation. (oeaw.ac.at)
  • Brodersen P, Arribas-Hernández L, ..., Nodine MD (2021) The Arabidopsis m6A-binding proteins ECT2 and ECT3 bind largely overlapping mRNA target sets and influence target mRNA abundance, not alternative polyadenylation. (oeaw.ac.at)
  • From that we are to coupled sites and inactivated receptors, docking both interactions as viable including climates and used sine download proteins. (evakoch.com)
  • The linker region between the BIR1 and BIR2 is implicated in the inhibition of caspase-3 and -7 whereas the BIR2 domain inhibits caspase-7 in a non-competitive manner [ 9 ]. (biomedcentral.com)
  • Electron microscopy typically shows fusion of epithelial cell foot processes, or so-called foot process effacement. (biomedcentral.com)
  • BACKGROUND: MAGT1 (magnesium transporter 1) is a subunit of the oligosaccharide protein complex with thiol-disulfide oxidoreductase activity, supporting the process of N-glycosylation. (bvsalud.org)
  • TGF-β1 binding to either subunit initiates their assembly into a heteromeric protein complex that consists of two type I and two type II subunits. (springer.com)
  • B29), and the -subunit of the E-mail: [email protected] interleukin (IL)-7 receptor [5, 6]. (lu.se)
  • The 414 amino acid recombinant protein has a predicted molecular mass of approximately 45.46 kD. (biolegend.com)
  • BioLegend carrier-free recombinant proteins provided in liquid format are shipped on blue-ice. (biolegend.com)
  • Application of recombinant bST is a biotechnology in which a recombinant-derived protein is administered by injection to the recipient animal without changing the animal's genetic composition or genome. (nationalacademies.org)
  • In knockout mice, BLNK deficiency results in a partial block in B cell development, and in humans BLNK deficiency results in a much more profound block in B cell development. (wikipedia.org)
  • Cancer cells share six features that distinguish them from normal cells: Autocrine production of growth signals, inability to respond to anti-growth signals, sustained angiogenesis, limitless replicative potential, tissue invasion and metastasis, and apoptosis avoidance [ 1 ]. (biomedcentral.com)
  • Here, we show a novel platform cell line, named 2D3, which enables the functional avidity of transduced TCRs to be evaluated efficiently and precisely. (oncotarget.com)
  • These results showed that 2D3 cell line was a novel and stable tool useful for the efficient and precise evaluation of the functional avidity of isolated and transduced TCRs in developing TCR-based immunotherapy. (oncotarget.com)
  • Surprisingly the induction of Th1 cell- versus Th2 cell-associated cytokines and the extent of NK cell transactivation do not correlate consistently with the potency of different αGC analogs or with the affinity with which they interact with the T?cell receptors (TCRs) of iNKT cells (Im et?al. (biotech-angels.com)
  • In the fetal bone marrow, the first committed cell in B-cell development is the early pro-B cell, identified by its ability to proliferate in the presence of interleukin-7 (IL-7). (medscape.com)
  • Caracterización Molecular de Adaptadores de Membrana d Linfocitos y Su Papel Como Mecanismo Regulador de la Activación de Linfocitos: Implicaciones en Artritis Reumatoide. (inibica.es)
  • JNK activation was noticed 20?min after addition of IL-1on JNK, p38, and Erk1/2 MAPK activation in individual T/C28a2 chondrocytes. (californiaehealth.org)
  • Second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. (biomedcentral.com)
  • 5 , 6 In concordance with the role of nodal cilia in L-R asymmetry, mutations in the motor proteins Kif3A and Kif3B, and the transcription factor Foxj1 in the mouse have demonstrated that ciliary motility is important for L-R asymmetry. (bmj.com)
  • Binds to protein and other compounds containing SH group. (medscape.com)
  • Second-line chemotherapy regimens vary, depending on whether hematopoietic stem cell transplantation (HSCT) is being considered. (medscape.com)
  • Curative hematopoietic stem cell transplantation of patients with X-linked immunodeficiency with magnesium defect causes fatal bleeding and thrombotic complications. (bvsalud.org)
  • Cell cycle-specific with activity in the S-phase as single agent and has for many years been combined with biochemical modulator leucovorin.Has activity as single agent that inhibits DNA replication and transcription. (medscape.com)
  • The signal transducer and activator of transcription 5A (STAT5A) and STAT5B transcription factors have a conserved functional domain structure organized in N-terminal oligomerization, Coiled-coil, DNA-binding, Linker, SH2 and C-terminal transactivation domain. (nature.com)
  • BLNK's function and importance in B cell development were first illustrated in BLNK deficient DT40 cells, a chicken B cell line. (wikipedia.org)
  • This occurs both through KM 11060 direct stimulation of iNKT cell functions and by transactivation of other effectors most notably NK cells and dendritic cells (Brennan et?al. (biotech-angels.com)
  • Although all three TGFbeta isoforms and their receptors are present in ocular tissues, lack of TGFbeta2, but not TGFbeta1 or TGFbeta3, perturbs embryonic morphogenesis of the eyes in mice. (nih.gov)