Cell lines malignant cloning clone cells. Medical search. Frequent questions

Human BeWo cell line has been used to study the effects of Δ-9-tetrahydrocannabinol (Δ9-THC) on the proliferation and gene transcription in the BeWo trophoblast cell line. (sigmaaldrich.com)
Overexpression of SLAMF1 or SLAMF7 in IGHV mutated CLL cell models resulted in reduced proliferation and impaired responses to BCR ligation, whereas the knockout of both receptors showed opposing effects and increased sensitivity toward inhibition of components of the BCR pathway. (nature.com)
B cell receptor (BCR) signaling plays a critical role in driving proliferation and survival of the malignant clone in chronic lymphocytic leukemia (CLL), supported by the clinical activity of inhibitors targeted toward BCR-associated kinases [ 1 ]. (nature.com)
Six diatom species displayed specific anti-inflammatory, anticancer (blocking human melanoma cell proliferation), and anti-biofilm (against the bacteria Staphylococcus epidermidis ) activities whereas, none of the other microalgae were bioactive against the conditions tested for. (frontiersin.org)
Of interest, MM-derived MVs were enriched with the biologically active form of CD147, a transmembrane molecule previously shown by us to be crucial for MM cell proliferation. (oncotarget.com)
In summary, this study demonstrates the significance of MV shedding and MV-mediated intercellular communication on malignant plasma cell proliferation, and identifies the role of MV-enriched CD147 in this process. (oncotarget.com)
miRNA-149 was underexpressed in gastric cancer tissues and cells, while overexpression of miRNA-149 promoted cell apoptosis, retarded cell cycle, and inhibited proliferation and migration in AGS and MKN28 cells. (hindawi.com)
It possesses a unique forkhead domain combined with a fragment of the target gene to initiate transcription [ 10 ] and regulates various biological processes such as tumor cell differentiation, cell proliferation, and migration [ 11 ]. (hindawi.com)

These are independent clonal derivatives of a spontaneous malignant melanoma tumour in the mouse. (biologists.com)
Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells within the bone marrow. (oncotarget.com)
Using the clonal density Ca++ shift assay, transformation frequencies have been calculated relative to clonogenic cells plated. (grantome.com)

Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
The spontaneous immortalization of primary malignant cells is frequently assigned to their genetic instability during in vitro culturing. (biomedcentral.com)
The in vitro culture was established with cells isolated from ascites of a 60-year-old female patient with recurrent ovarian cancer. (biomedcentral.com)
The problem we have been concerned with is to find an in vitro correlate with tumorigenicity in a system of cell hybrids in the mouse. (biologists.com)
This study demonstrates in vitro that certain cell types from pleomorphic adenoma are able to clone and survive over a long term and develop subcutaneous tumors in nude mice. (biomedcentral.com)
In this report the role of versican was examined in adhesion of EOC spheroids and cells to peritoneal mesothelial cell monolayers in vitro as well as in formation of peritoneal tumors using an in vivo xenograft mouse model. (biomedcentral.com)

It is still poorly understood how and which benign pleomorphic adenoma cells transform into its malignant form, carcinoma ex pleomorphic adenoma. (biomedcentral.com)
We have established five cell systems from a benign pleomorphic adenoma of the parotid gland of a 61-year-old woman. (biomedcentral.com)
We established and characterized five cell systems (designated as SM-AP1 to SM-AP5) from a benign pleomorphic adenoma of the parotid gland. (biomedcentral.com)
The histological features of squamous cell carcinoma from the transplanted cell systems in nude mice might suggest a secondary onset of malignancy from a pre-existing benign adenoma. (biomedcentral.com)
We investigated cells and conditioned media of the three human keratinocyte cell lines HaCaT (non-tumorigenic), A5 (benign, tumorigenic) and II-4RT (malignant, tumorigenic) with regard to production and secretion of the collagenases-1 to -3 (MMP-1, MMP-8 and MMP-13) and TIMP-1 using semi-nested RT-PCR, Western blots, ELISA, immunocytochemistry and casein zymography. (uni-bielefeld.de)

Transplanted cells in nude mice formed subcutaneous tumors, which had histological features of squamous cell carcinoma with apparent keratinizing tendencies. (biomedcentral.com)
Such tumor-specific T RM cells are recognized as both necessary and sufficient for long-lived protection against tumors in peripheral tissue locations. (frontiersin.org)
Cancer can be considered a disease of immune dysfunction, with a failure of immune recognition leading to the outgrowth of malignant cells as tumors ( 1 ). (frontiersin.org)
Following effective priming in lymph nodes, T cells traffic to tumors and other peripheral tissues. (frontiersin.org)
In a growing number of cases, CD8 T cells have been shown to mediate the regression of large bulky tumors, resulting in durable long-term disease remissions ( 5 ). (frontiersin.org)
Importantly, both spheroids and cells with reduced expression of versican demonstrated significantly impaired ability to generate peritoneal tumors when injected intraperitoneally into athymic nude mice. (biomedcentral.com)
It is reported that FOXC1 plays an important role in the occurrence, development, and migration of malignant tumors [ 12 ]. (hindawi.com)

The use of human telomerase reverse transcriptase-immortalized bone marrow mesenchymal stromal cells (hTERT-BMSCs) as vehicles to deliver antinociceptive galanin (GAL) molecules into pain-processing centers represents a novel cell therapy strategy for pain management. (hindawi.com)
Over the last decade, significant investigation in the MM field has demonstrated that the interaction of malignant PCs with BM stromal cells within the microenvironment is essential for survival of the PC clone [ 5 , 6 ]. (oncotarget.com)

Its lethality is a consequence of the lack of symptoms or biomarkers enabling the early diagnosis of disease, and the propensity of malignant cells to seed the peritoneal cavity. (biomedcentral.com)
Mesothelial cells are specialized cells that outline the entire surface of the peritoneal cavity. (biomedcentral.com)

Although pathologists in their daily services of surgical pathology had recognized such singular atypical cells in pleomorphic adenomas, these atypical cells were not always regarded as evidence or the source for malignant transformation [ 4 - 6 ]. (biomedcentral.com)
The effect of 3 retinoid derivatives in transformation frequency and malignent potential in vivo is being quantitated. (grantome.com)
The normal and carcinogen altered mouse epidermal clones are being examined for Ca++ dependent changes in potein synthesis in an effort to define molecular markers of normal """"""""differentiation"""""""" and of transformation on these cells. (grantome.com)
Such markers are of particular importance, since reliable markers of transformation in lining epithelial cell have not yet been defined. (grantome.com)
This study revealed the malignant transformation of EBV-infected cells in CAEBV. (yusukeokuno.com)
The lytic reactivation caused by the deletions is suggested to drive the malignant transformation of infected cells. (yusukeokuno.com)

The relationship between the 'spontaneous' frequency of sister-chromatid exchanges (SCE) and tumorigenicity was studied in a series of hybrids between a C57BL melanoma cell line and diploid cells, but no correlation was found between the 2 variables. (biologists.com)

Bone marrow stem cells, including the pluripotent hematopoietic stem cells (HSCs) and bone mesenchymal stem cells (BMSCs), are being considered as potential targets for cell and gene therapy-based approaches against a variety of different diseases. (hindawi.com)

J Cell Sci (1980) 42 (1): 117-126. (biologists.com)

The observation of this intercellular communication and that MM cells modify the microenvironment is highly suggestive that one of the first biologically relevant changes necessary for progression of MGUS or SMM to MM is for a member(s) of the clone to evolve and acquire the molecular changes needed to reprogram its immediate microenvironment into a supportive, growth-promoting microenvironment. (oncotarget.com)
Molecular cloning data suggest 87% amino acid identity between mouse and human L1 molecules. (bdbiosciences.com)

Although human HSCs as vehicles to treat metachromatic leukodystrophy (MLD) has been used to treat patients with early onset MLD in a phase I/II trial, the HSCs give rise to all different blood cell lineages, such as the myeloid and lymphoid cell lineages [ 11 ]. (hindawi.com)

Predominance of BoCD8-positive T lymphocytes in vascular lesions in a 1-year-old cow with concurrent malignant catarrhal fever and bovine viral diarrhea virus infection. (microbiologyresearch.org)
Characterized by cell-surface molecules including CD103, CD69, and CD49a, T RM -like tumor-infiltrating lymphocytes (TILs) can be found in a wide range of human cancers, where they portend improved prognosis. (frontiersin.org)
Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. (lookformedical.com)
The N-terminal part of gp41 is thought to be involved in CELL FUSION with the CD4 ANTIGENS of T4 LYMPHOCYTES, leading to syncytial formation. (lookformedical.com)

Studies have increasingly focused on the potential therapeutic effects of stem cell transplantation for neurological diseases [ 10 ]. (hindawi.com)

A previous study demonstrated that SLAMF1, SLAMF2, and SLAMF7 receptors are rather downregulated on CLL cells as compared to their normal B cell counterpart [ 12 ], suggesting that high expression of these molecules may have detrimental (e.g., antiproliferative) effects in the CLL context. (nature.com)
The use of cell lines as "biological minipumps" to chronically deliver antinociceptive molecules into the pain-processing centers of the spinal cord represents a newly developed technique for the treatment of pain [ 3 ]. (hindawi.com)
The CAISMOV24 line was assessed for cell growth, production of soluble biomarkers, expression of surface molecules and screened for typical mutations found in serous ovarian carcinoma. (biomedcentral.com)
The cell surface molecules EpCAM, PVR and CD73 are overexpressed on CAISMOV24 cells compared to the primary malignant cells. (biomedcentral.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
These cells, among other functions, provide a protective barrier against invading pathogens and secrete surfactant molecules to provide a non-adhesive surface. (biomedcentral.com)

In this study, the new epithelial ovarian cancer cell line CAISMOV24 was described and compared with its original low-grade serous ovarian carcinoma. (biomedcentral.com)
Additionally, CAISMOV24 cell line was characterized as a low-grade serous ovarian carcinoma, which still resembles its primary malignant cells. (biomedcentral.com)

Resident memory (T RM ) cells are a distinct tissue-localized T cell lineage that is crucial for protective immunity in peripheral tissues. (frontiersin.org)
whereas T EM cells were shown to recirculate predominantly through blood, and peripheral tissues ( 10 ). (frontiersin.org)
In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
Successful colonization of the abdomen by EOC cells and spheroids to a large extent depends on their ability to attach to mesothelial surfaces of the peritoneal organs and tissues. (biomedcentral.com)
qRT-PCR was used to detect the expression of miRNA-149 and FOXC1 in gastric cancer tissues and cells. (hindawi.com)

Classical definitions of memory T cells derive from the belief that T cells localize and recirculate predominantly throughout the blood and secondary lymphoid organs ( 7 , 8 ). (frontiersin.org)

However, cell lines are known for their susceptibility to genetic and metabolic alterations, which can alter their characteristics in relation to the primary malignant cells. (biomedcentral.com)
In addition, they had ductal arrangements or plasmacytoid appearances of tumor cells and myxoid or hyaline stromata, indicating some characteristics of pleomorphic adenoma. (biomedcentral.com)
Characteristics of the herpesvirus of malignant catarrhal fever isolated from captive wildebeest calves. (microbiologyresearch.org)
Fluorescence histograms were derived from gated events with the side and forward light scatter characteristics of viable M21 cells. (bdbiosciences.com)
The 5G3 antibody was developed against a human neuroblastoma cell line to use as a probe for the elucidating the biological characteristics of neuroblastoma. (bdbiosciences.com)

The recent success of T cell immune checkpoint inhibitor (ICI) therapies for cancer has revealed CD8 T cells as potent mediators of immunity against advanced cancers ( 4 , 5 ). (frontiersin.org)

Cellular differentiation of this stem cell type occurs when hormonal precursors are added to the medium. (sigmaaldrich.com)
SM-AP1-3 cells were immunopositive for keratin only, indicating their duct-epithelial or squamous cell differentiation, while SM-AP4/5 cells were positive for both keratin and S-100 protein, indicating their myoepithelial cell differentiation. (biomedcentral.com)
It is proposed to use a newly derived mouse epidermal clone 291, selected both for high efficiency and maintenance of terminal differentiation response to Ca++ in an assay designed to more precisely quantitate chemical carcinogen effects in terminally differentiating epithelial cells, Alteration of the response to calcium is quantitated by counts of colonies which proliferate in 1.4 mM Ca++ relative to differentiation and sloughing of normal colonies inder these conditions. (grantome.com)

therefore, antibody preparations containing this preservative agent must not be used in cell cultures nor injected into animals. (bdbiosciences.com)
Sodium azide may be removed by washing stained cells or plate-bound antibody or dialyzing soluble antibody in sodium azide-free buffer. (bdbiosciences.com)

CAISMOV24 cell line harbored KRAS mutation with wild type TP53 , therefore it is characterized as low-grade serous carcinoma. (biomedcentral.com)
At the time of progression, the clone with BCORL1 disappeared and the second clone acquired either additional PD-L1 3′ -UTR structural variations or a DDX3X p.R528C mutation. (yusukeokuno.com)
At the onset of blastic crisis, the clones with the additional PD-L1 3′-UTR structural variations acquired a DDX3X p.R528H mutation or a deletion affecting the DDX3X 3′ -UTR. (yusukeokuno.com)

Chronic active EBV infection (CAEBV) is an intractable disease characterized by persistent and active EBV infection in T and/or NK cells. (yusukeokuno.com)

These findings suggest that cell fusion might have induced epigenetic SCE frequency changes possibly in the same way as modulation of SCE frequencies is known to occur in the human leukocyte series. (biologists.com)

Indeed, our experiments showed significantly decreased degranulation capacity of primary NK cells from CLL patients expressing low levels of SLAMF1 and SLAMF7. (nature.com)
The conditioned media of the malignant II-4RT cells contain significantly more MMP-1 and MMP-8 than those of HaCaT or A5 as evidenced by immunoblotting and ELISA. (uni-bielefeld.de)

This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
Allogeneic-donor-derived cells can be genetically modified to eliminate expression of HLA-A. (ashpublications.org)
HLA-A disruption from donor cells is a step toward generating allogeneic cells as an off-the-shelf therapeutic. (ashpublications.org)
Long-term engraftment of allogeneic cells necessitates eluding immune-mediated rejection, which is currently achieved by matching for human leukocyte antigen (HLA) expression, immunosuppression, and/or delivery of donor-derived cells to sanctuary sites. (ashpublications.org)

The first human, trophoblastic endocrine cell type to be maintained in continuous culture. (sigmaaldrich.com)
Furthermore, none of the 6 diatom species tested were toxic on normal human cells. (frontiersin.org)
this limitation has been overcome via ectopic expression of human telomerase reverse transcriptase (hTERT), the catalytic component of telomerase, to produce large quantities of these cells as an attractive source for cellular transplantation [ 16 - 18 ]. (hindawi.com)
Herein we present clear evidence that not only do both patient MM cells and human MM cell lines (HMCLs) release MVs, but that these MVs stimulate MM cell growth. (oncotarget.com)
Flow cytometric analysis of CD171 expression on human melanoma cells. (bdbiosciences.com)
M21 human melanoma cells were stained with either Purified Mouse IgG2a, κ Isotype Control (Cat. (bdbiosciences.com)
grey line histogram) or Purified Mouse Anti-Human CD171 (Cat. (bdbiosciences.com)
Human gastric cancer cell lines AGS and MKN28 were cultured and transfected with miR-149 overexpression plasmid and its control or FOXC1 siRNA and its control. (hindawi.com)
The human gastric epithelial permanent cell line (GES-1), human gastric cancer cell lines (AGS, BGC-823, MKN45, and SGC-7901), and HEK293 cells were provided by the Biomedical Experiment Center of Xi'an Jiaotong University. (hindawi.com)

Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)

Failure of spheroids lacking versican to disaggregate as efficiently as controls could be attributed to a reduced cell migration that was observed in the absence of versican expression. (biomedcentral.com)

TIMP-1 was found only in extracts of all three cell lines, predominantly in A5. (uni-bielefeld.de)

In our previous study, we proposed a concept of focal carcinomas in pleomorphic adenoma which is an advanced stage of accumulated atypical cells with P53 over-expressions as an initial stage or a latent form of apparent carcinomas secondarily arising in pleomorphic adenoma [ 3 ]. (biomedcentral.com)

The lack of targeted immunotherapeutic approaches for T cell malignancies results in part from potential risks associated with targeting broadly expressed T cell markers, namely T cell depletion and clinically significant immune compromise. (mdpi.com)
Indeed a wealth of studies from humans and mouse models establishes a particularly potent role for CD8 T cells in controlling the outgrowth of malignancies ( 3 ). (frontiersin.org)

CD8 + CTL clones recognizing minor H antigens were isolated from five patients studied. (aacrjournals.org)
Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)

Taken together these data suggest that versican regulates the development of peritoneal metastasis originating from cells and spheroids. (biomedcentral.com)

In this study, these difficulties were overcome by cloning the entire AlHV-1 genome as a stable, infectious and pathogenic bacterial artificial chromosome (BAC). (microbiologyresearch.org)
The loxP -flanked BAC cassette was excised from the genome of reconstituted virions by growing them in permissive cells stably expressing Cre recombinase. (microbiologyresearch.org)
Cloning and mutagenesis of the murine gammaherpesvirus 68 genome as an infectious bacterial artificial chromosome. (microbiologyresearch.org)
Each grey line indicates an EBV genome from a patient. (yusukeokuno.com)
Large deletions of the viral genome were frequent across three diseases (CAEBV, extranodal NK/T-cell lymphoma, diffuse large B-cell lymphoma). (yusukeokuno.com)

While a great deal of effort has focused on defining their role in immunity to infections, studies now reveal T RM cells as a vital component of the host immune response to cancer. (frontiersin.org)
Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
This review will recount the path to discovering the importance of resident memory CD8 T cells as they pertain to cancer immunity. (frontiersin.org)
As the field of cancer immunotherapy advances rapidly, it is now crucial to understand how the dissemination and maintenance of tumor-specific T cells can be optimally achieved. (frontiersin.org)
These early classifications of T cell memory were quickly brought to bear on the question of what T cell subset provides the best immunity against cancer. (frontiersin.org)
In this study, we investigated the inhibitory effects of miR-149 on the biological functions of gastric cancer cells by targeting FOXC1. (hindawi.com)

This insertion allowed the production of an AlHV-1 BAC clone stably maintained in bacteria and able to regenerate virions when transfected into permissive cells. (microbiologyresearch.org)

Individual cells and multicellular aggregates, or spheroids, seed these metastases, both commonly found in ascites. (biomedcentral.com)

Indeed, the potent pathotropic migratory properties of BMSCs and ability to circumvent both the complications associated with immune rejection of allogenic cells and many of the moral reasons associated with embryonic stem cell use suggest that BMSCs are most promising stem cells as a potential target for the clinical use of genetically engineered stem cells [ 14 , 15 ]. (hindawi.com)

However, obtaining primary neuronal cells from adult tissue is difficult and faces major ethical issues in clinical practice. (hindawi.com)
The rows contain clinical information, data on EBV-infected cells, and the somatic and germline mutations found. (yusukeokuno.com)

The malignant clone secretes increased amounts of distinct collagenases compared to the non-tumorigenic cell line, thereby verifying a correlation between biological behaviour and the amount of collagenases. (uni-bielefeld.de)

Signaling Lymphocytic Activation Molecule Family (SLAMF) receptors are a group of nine type I transmembrane receptors that are mainly expressed on a variety of immune cells. (nature.com)
Tumor development has been said to occur in three distinct steps: inefficient elimination of early transformed cells, development of a state of equilibrium between tumor cells and immune cells, and tumor escape from immune pressure ( 2 ). (frontiersin.org)
While innate immune cells are important for early tumor immune surveillance, T cells are fundamentally recognized for their crucial role in the antigen-specific recognition and elimination of malignantly transformed cells ( 2 ). (frontiersin.org)

Since SLAMF receptors play a role in NK cell biology, we reasoned that these receptors may impact NK cell-mediated CLL immunity. (nature.com)
In addition to highlighting key studies that directly implicate T RM cells in anti-tumor immunity, we will highlight earlier work that implicitly suggested their importance. (frontiersin.org)

It has been suggested that sister-chromatid exchange (SCE) might reflect a pathway by which cells can repair certain forms of chromosome damage( Latt & Juergens, 1977 ). (biologists.com)

the silencing of FOXC1 inhibited the biological function of AGS and MKN28 cells. (hindawi.com)

Neurite adhesion molecule L1 has been implicated in neuron-neuron and neuron-Schwann cell adhesion in vertebrates. (bdbiosciences.com)
The data demonstrate that versican is instrumental in facilitating cell and spheroid adhesion to the mesothelial cell monolayers, as its reduction with specific shRNAs led to decreased adhesion. (biomedcentral.com)

They are known to be involved in the regulation of NK and T cell responses, mostly by homotypic interactions except for SLAMF2 (CD48) and SLAMF4 that interact with each other [ 10 ]. (nature.com)
Informed by studies in infectious disease models, and instructed by a clear role for T RM cells in autoimmunity, we will discuss strategies for therapeutically promoting T RM responses in settings where they don't naturally occur. (frontiersin.org)
The persistence of such responses is fundamentally thought to be based on the ability of T cells to act as potent effectors and, subsequently, generate long-lived memory ( 6 ). (frontiersin.org)

It has also been used to study placental transfer of highly purified non-dioxin-like polychlorinated biphenyls in BeWo cells. (sigmaaldrich.com)
In this study, our goals were to determine if MM cells release MVs, and if so, begin to characterize their biologic activity. (oncotarget.com)

In B cells, this class of receptors has been shown to be expressed in distinct patterns associated with development and activation [ 11 ]. (nature.com)

Studies in infectious disease models have provided a wealth of information regarding memory CD8 T cell generation and localization. (frontiersin.org)

Hybrids in which malignancy was suppressed and malignant segregants derived from them showed virtually identical SCE frequencies. (biologists.com)

A great many noxious agents capable of inducing SCE in tissue culture cells are carcinogenic (see, for example, Wolff, 1977 ). (biologists.com)

Additionally, comparative genomic hybridization was employed to compare genomic alterations between the CAISMOV24 cell line and its primary malignant cells. (biomedcentral.com)
Although the cell line had developed alongside the accumulation of genomic alterations (28 CNV in primary cells and 37 CNV in CAISMOV24), most of them were related to CNVs already present in primary malignant cells. (biomedcentral.com)
Ideally, the more a cell line resembles the primary malignant cells, the more useful it will be for scientific research. (biomedcentral.com)

Cell lines from various tumor types have been developed for use as a tumor model for controlled laboratory studies. (biomedcentral.com)

The construction of this cell line is the first promising step in the regulation of GAL secretion from hTERT-immortalized BMSCs, and the potential application of this system may provide a stem cell-based research platform for pain. (hindawi.com)

Analysis of possible markers is being performed by polyacrylamide gel electrophoresis of metabolically labell proteins, obtained from transformed vs non transformed subclones of line 291 which have been incubated in culture medium containing a range of Ca++ concentrations. (grantome.com)

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