• These data suggest that crosstalk mechanisms exist between the 15-LOX-2 gene and PPARgamma to counterbalance expression and help explain the inverse relationship of these genes in normal versus cancer cells. (labome.org)
  • In the present study, we investigated the effect of CS on the expression of progesterone production-related genes in KGN cells, derived from human granulosa-like tumor. (nii.ac.jp)
  • AQPs 1, 3, 4, 5, 8 and 9 were screened in the NSCLC cell line H1299, and the present results showed that AQP5 mRNA was upregulated compared with the other AQP genes. (spandidos-publications.com)
  • Moreover, we studied the transcriptional targets in these cells in response to cisplatin, particularly the expression profiles of genes associated with DNA damage response. (uio.no)
  • The genes of mammalian target of rapamycin (mTOR), RICTOR, and RAPTOR survival pathways, which are often overexpressed in majority of the cancers, were significantly downregulated within few hours of the treatment of SKOV3 cells with C1q and globular head modules. (nih.gov)
  • In vivo genomic footprinting of thyroid hormone-responsive genes in pituitary tumor cell lines. (asm.org)
  • Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3 variants can occur through protein kinase C-dependent and -independent pathways. (asm.org)
  • We isolated a group of genes that are rapidly and transiently induced in 3T3 cells by tetradecanoyl phorbol acetate (TPA). (asm.org)
  • For this purpose, the introduction of genes that confer tumors with bioluminescent properties has been a critical advance for oncologic studies in rodents. (bio-protocol.org)
  • Methods of introducing bioluminescent genes, such as firefly luciferase, by viral transduction has allowed for the production of tumor cell lines that can be followed in vivo longitudinally over long periods of time. (bio-protocol.org)
  • Lower methylation of CpNpG sequences characteristic of all transformed cells could result from the disturbance of one of several plant DNA methyltransferase genes following its homologous recombination with the M·EcoRII gene. (deepdyve.com)
  • Activation of tumor suppressor genes in nontumorigenic revertants of the HeLa cervical carcinoma cell line -- Boylan et al. (aacrjournals.org)
  • Cell fusion experiments indicated that the revertant phenotypes of HA and HF cells resulted from mutations in cellular genes that activate one or more tumor suppressor genes. (aacrjournals.org)
  • MicroRNAs (miRNAs) regulate cell proliferation, differentiation, and apoptosis functioning as tumor suppressor genes but their role in NET proliferation and metastasis has not been fully evaluated. (enets.org)
  • Aberrant promoter methylation of tumor suppressor genes has not been fully investigated in pediatric tumors. (nih.gov)
  • Therefore, we examined the methylation status of nine genes (p16(INK4A), MGMT, GSTP1, RASSF1A, APC, DAPK, RARbeta, CDH1 and CDH13) in 175 primary pediatric tumors and 23 tumor cell lines using methylation-specific PCR. (nih.gov)
  • High rates of loss of heterozygosity commonly affect multiple chromosomes in individual tumor types, yet the number of known tumor suppressor genes (TSGs) systematically mutated in the corresponding tumors is usually low. (pasteur.fr)
  • We have identified patterns of gene expression that may further reveal aspects of breast carcinogenesis, and a robust method for examining changes in clinically important genes using archival biopsies and across stroma-tumour boundaries. (edu.au)
  • These leukemias are active when cells are transferred to other mice When the virus genome is inserted inside the host genome it is then able to transcribe its own viral genes. (wikipedia.org)
  • We hypothesized that a minimum inhibitory sequence (MIS) peptide of p16 (p16-MIS) may play a role in the anti-tumor effect in p16-deficient bladder tumor cell lines using the Wr-T system. (spandidos-publications.com)
  • Therefore, the aim of the present systematic review was to summarize the available literature on the in vitro anti‑tumor effects of metformin on head and neck squamous cell carcinoma (HNSCC). (spandidos-publications.com)
  • mTOR inhibitors are therefore considered effective anti-tumor reagents but they may also induce an activation of PI3K/Akt and MAPK pathways as a compensatory action and reduce their own anti-tumor activities. (enets.org)
  • Collectively, these results demonstrate that DAMPs released from chemically stressed cancer cells can activate DCs via TLR4 and enhance the induction of an anti-tumor T-cell immune response, delineating a clinically relevant immuno-adjuvant pathway triggered by DAMPs. (nature.com)
  • Efficiently killing tumor cells with chemical drugs while enhancing induction of the anti-tumor immune response is becoming increasingly important. (nature.com)
  • DCs have a strong ability to activate CD8 + cytotoxic T lymphocytes and CD4 + Th1 immunity and therefore play an essential role in the anti-tumor immune response. (nature.com)
  • Rapid reconstitution of anti-tumor recognition and enhanced tumor infiltration of treated NK cells was monitored by 24 h co-incubation of HNSCC tumor spheroids with cetuximab (1 μg/ml) and was characterized by increased IFN-γ and TNFα secretion. (frontiersin.org)
  • Pharmacologic targeting of the unique metabolism of solid tumors could alter the tumor microenvironment to provide more favorable conditions for anti-tumor therapy. (pnas.org)
  • However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cells. (hep.com.cn)
  • Cell lines derived from human tumors for vaccine manufacture have been approved by FDA for trials although it is certainly not convincing (to me at least) that these vaccines will not induce tumors in the recipients, nor that the vaccines will be free from advantageous agents from the substrates. (sanevax.org)
  • In wild-type (wt) p53 tumors, prolonged suppression of MGMT with O 6 -benzylguanine and concomitant activation of p53/p21 pathway to induce a G 1 -S arrest results not only in elevated killing due to an increase of BAX to BCL2 ratio but also in an enhancement of the efficacy of mismatch repair via the up-regulation of mismatch repair components. (aacrjournals.org)
  • We show that C1q and the recombinant globular head modules induce apoptosis in SKOV3 cells in a time-dependent manner. (nih.gov)
  • The study demonstrated that CCRF-CEM cells failed to induce synergistic response with any of the investigated chemotherapies, but importantly no inhibition was observed either. (omicsonline.org)
  • 100-fold reduced cloning efficiencies in semisolid medium relative to HeLa cells and failed to induce s.c. tumors when injected into nude mice. (aacrjournals.org)
  • However, the supernatants of chemically stressed CRC cells failed to induce phenotypic maturation and cytokine production in TLR4-deficient DCs, indicating an essential role of TLR4 in DAMP-induced DC maturation and activation. (nature.com)
  • Furthermore, pulsing with the supernatants of chemically stressed CRC cells did not efficiently induce an IFN-γ-producing Th1 response in TLR4-deficient DCs. (nature.com)
  • Through experiments performed in vivo and in vitro , DAMPs induced by chemical drugs have been demonstrated to stimulate dendritic cells (DCs) to induce an anti-cancer immune response. (nature.com)
  • Tumors can induce generation and accumulation of the immunosuppressive cells such as regulatory T cells in the tumor microenvironment, contributing to tumor escape from immunological attack. (jimmunol.org)
  • It has been shown that imDC can induce T cell anergy, generate regulatory T (Treg) cells, and promote alloantigen-specific tolerance ( 6 , 7 ). (jimmunol.org)
  • Essential to these studies is the ability to both track tumor development and quantify tumor burden in vivo . (bio-protocol.org)
  • Paramount to tracking cells in vivo is the ability to detect them externally by minimally invasive methods. (bio-protocol.org)
  • Enzymatic bioluminescence using luciferase derived from the firefly ( Photinus pyralis ) is a widely used method for image-based cell tracking in vivo . (bio-protocol.org)
  • 2) Each metastatic cell grew significantly larger than parental AZ521 in vivo. (nii.ac.jp)
  • Vaccines composed of DCs pulsed with the supernatants of chemically stressed CRC cells induced a more significant IFN-γ-producing Th1 response both in vitro and in vivo . (nature.com)
  • No viable tumor cells were evident four hours after injection by ex vivo culture. (plos.org)
  • Loss of vascular integrity following treatment was demonstrated by an increased permeability of endothelial cell monolayers in vitro and by CD31 immunostaining of treated tumors in vivo . (plos.org)
  • These findings predict that inhibition of HIF1 or PDK1 in vivo could alter tumor metabolism and increase oxygen consumption, which would lead to decreased overall tumor oxygenation. (pnas.org)
  • Also, in vivo delivery of Ag to nonactivated or resident DCs, which phenotypically resemble imDCs, results in the induction of tolerance of CD8 + T cells ( 8 ). (jimmunol.org)
  • Small cell lung cancer (SCLC) is distinguished by early dissemination and excessive numbers of CTCs, which allowed for the ex vivo expansion of six permanent CTC lines taken from relapsed patients. (jcmtjournal.com)
  • Lymphotoxin-alpha (LT-alpha) and lymphotoxin-beta (LT-beta), two related cytokines produced by lymphocytes that are cytotoxic for a wide range of tumor cells in vitro and in vivo. (wikipedia.org)
  • We have evidence to suggest that one cell line, COH-BR-5 (ER-negative), lacked hgpx1 gene expression prior to culture. (unboundmedicine.com)
  • A tumor suppressor gene DIRAS1 was upregulated after SB treatment, displaying its anti-cancer potential at molecular level. (springer.com)
  • For example, gastrointestinal stromal tumors (GIST) that harbor activating mutations in the c-KIT gene are sensitive to treatment with imatinib mesylate, a tyrosine kinase inhibitor, whereas those without c-KIT mutations are less sensitive ( 1 ). (aacrjournals.org)
  • DMS and DNase I footprinting identified protected G residues in the Pit-1, Sp1, and Zn-15 binding sites of the GH gene in GC, but not in 235-1, cells. (asm.org)
  • We conclude that the GH gene is accessible to specific nuclear proteins in GC, but not in 235-1, cells and that T3 enhances this interaction, although there is no evidence of TR binding to the low-affinity rat GH TRE. (asm.org)
  • The Effect of the Gene Encoding EcoRII DNA Methyltransferase on the Phenotype of Transgenic Tumor. (deepdyve.com)
  • 2004-10-10 00:00:00 Several tumor cell lines were obtained by transforming Nicotiana tabacumplants with the recombinant Ti plasmid comprising the gene encoding EcoRII DNA methyltransferase (M·EcoRII) and subjected to analysis. (deepdyve.com)
  • Southern blot-hybridization showed that the M·EcoRII gene was present in the cells of all transformed lines. (deepdyve.com)
  • Correlation of Ataxia-Telangiectasia-Mutated (ATM) gene loss with outcome in head and neck squamous cell carcinoma. (semanticscholar.org)
  • Expression of an exogenous tumor-necrosis-factor (TNF) gene in TNF-sensitive cell-lines confers resistance to TNF-mediated cell-lysis. (ugent.be)
  • Together with its functional properties and chromosomal localization, these findings substantiate ZAC as a good candidate for the tumor suppressor gene on 6q24-q25. (cnrs.fr)
  • In all lines, the int-1 gene was identically rearranged due to insertion of proviral DNA of the Mouse Mammary Tumor Virus, but the expression of int-1 varied with the state of differentiation of the cells. (stanford.edu)
  • Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines. (nih.gov)
  • The most frequently methylated gene in both primary tumors and cell lines was RASSF1A (40, 86%, respectively). (nih.gov)
  • All the cell lines presented the normal alleles for the BAX gene while only in one of the tumor samples a heterozygous frameshift mutation was found. (oup.com)
  • The results indicate that frameshift mutations in the BAX gene, possibly arising as a consequence of microsatellite instability (detectable in these tumors), is detectable in human ovarian cancer although quantitatively it does not appear to be a major determinant of the low apoptotic response to chemotherapy observed in ovarian cancer cells. (oup.com)
  • We integrate gene expression profiles of cancer cell lines from two E2F1-driven highly aggressive bladder and breast tumors, and use network analysis methods to identify the tumor type-specific core of the network. (nature.com)
  • By combining logic-based network modeling, in vitro experimentation, and gene expression profiles from patient cohorts displaying tumor aggressiveness, we identify and experimentally validate distinctive, tumor type-specific signatures of receptor proteins associated to epithelial-mesenchymal transition in bladder and breast cancer. (nature.com)
  • Here, we describe a strategy in which the mitochondrial metabolism of tumor cells is increased by pharmacologic inhibition of hypoxia-inducible factor 1 (HIF1) or its target gene pyruvate dehydrogenase kinase 1 (PDK1). (pnas.org)
  • In addition to these stable genetic alterations, the hypoxic microenvironment of solid tumors stimulates epigenetic changes in gene expression through the hypoxia-inducible factor 1 (HIF1) transcription factor that also contribute to the metabolic state of tumor cells ( 12 - 16 ). (pnas.org)
  • We first examined the effect of the HIF inhibitor echinomycin on the hypoxic expression of the HIF target gene PDK1 by immunoblot in RKO and Su.86 human tumor cells exposed to hypoxia. (pnas.org)
  • ATCC offers isogenic cell lines created using gene editing tools such as CRISPR/Cas9 that are ideal for identifying novel, personalized treatment regimens. (atcc.org)
  • These cells either constitutively or inducibly express a reporter gene (such as GFP or luciferase). (atcc.org)
  • ATCC has created gene mutation lists based on the ATCC tumor cell line collection and known mutation information maintained in the Sanger Institute COSMIC database. (atcc.org)
  • It provides a feasible mechanism of early tumour vascular supply which can co-exist and incorporate with later angiogenic mechanisms. (biomedsearch.com)
  • Studies of multidrug resistance mechanisms have relied on the analysis of cancer cell lines that have been selected and present cross-reactivity to a broad range of anticancer agents. (scielo.br)
  • Cell culture models of normal urothelial cells are important for studying differentiation, disease mechanisms and anticancer drug development. (iospress.com)
  • To investigate the molecular mechanisms by which carcinoma cells metastasize, we have established liver metastatic models. (nii.ac.jp)
  • In summary, our results suggest the existence among cells of the same cell line of discrete mechanisms for acquisition of resistance to TNF-mediated cell lysis. (elsevier.com)
  • Such cell lines have been used as models in studies of resistance to redox cycling anticancer drugs. (unboundmedicine.com)
  • This work characterises a multidrug resistant cell line, originally selected for resistance to the Vinca alkaloid vincristine and derived from the human erythroleukaemia cell K562. (scielo.br)
  • This cell line, named Lucena 1, overexpresses P-glycoprotein and have its resistance reversed by the chemosensitisers verapamil, trifluoperazine and cyclosporins A, D and G. Furthermore, we demonstrated that methylene blue was capable of partially reversing the resistance in this cell line. (scielo.br)
  • Metallothionein expression and resistance to cisplatin in a human germ cell tumor cell line. (aspetjournals.org)
  • Expression of intracellular metallothionein (MT) has been linked to cis-diamminedichloroplatinum (cDDP) resistance in human germ cell tumor cell lines. (aspetjournals.org)
  • To determine whether exposure to cDDP would select for cells with increased MT expression, the MT content of the human teratocarcinoma cell line T7800 was measured after development of resistance to cDDP by exposure to progressively higher drug concentrations (6.25-25 microM). (aspetjournals.org)
  • cDDP resistance in a variety of other human tumor cell lines correlated with MT content, with no significant difference in glutathione level. (aspetjournals.org)
  • These data indicate that selection in vitro for cDDP resistance in human germ cell tumors coselects for cells with enhanced MT content. (aspetjournals.org)
  • These results suggest that increased MT expression is concomitant with increased cDDP resistance in a variety of human tumor cell lines. (aspetjournals.org)
  • However, measured differences in MT levels may not accurately reflect the degree of cDDP resistance differences among those cells. (aspetjournals.org)
  • Research in this laboratory ( 9 ) has identified that the two prominent factors in the resistance of pancreatic neoplasms to alkylating chemotherapeutic agents are ( a ) the high level of O 6 -methylguanine-DNA methyltransferase (MGMT) in the tumor and ( b ) the widespread mutation of p53 that prevents p53-mediated cell cycle arrest in response to DNA damage ( 10 ). (aacrjournals.org)
  • Selection of nitrogen mustard resistance in a rat tumor cell line results in loss of guanine-O6-alkyl transferase activity. (aspetjournals.org)
  • Acute and chronic exposition of colon cancer cell lines to CT/CTE PEDF-derived peptides decreased drug-resistance to conventional colorectal cancer treatments, such as oxaliplatin or irinotecan. (oncotarget.com)
  • For this reason tumour stem cells display some same general characteristics as healthy stem cells (SCs) such as quiescence, self-renewal, asymmetric cell division, cell regulation via Wnt, Notch, Sonic Hedgehog signaling (Shh), and resistance to toxic substances and drugs. (oncotarget.com)
  • Apoptosis resistance occurs in various tumors. (biomedcentral.com)
  • Enforced E2F1 expression in advanced tumors and metastases of different kinds of cancers correlates with pronounced resistance towards therapy and poor patient prognosis 14 , 15 . (nature.com)
  • Collectively, analysis of tumor samples from multiple independent patient cohorts revealed that MET was amplified in tumors from 9 of 43 (21%) patients with acquired resistance but in only two tumors from 62 untreated patients (3%) ( P = 0.007, Fisher's Exact test). (pnas.org)
  • [ 9 ] However, an advantage of the analysis of ctDNA in liquid biopsy is the detection of molecular changes which are occurring within the tumors in real time, especially during development of drug resistance to targeted agents. (jcmtjournal.com)
  • These results suggest that AtT-20/D16v cells produce gamma MSH-LIs with molecular weights of 31K, 21-23K, 16-17K, 13-14K, and 3.8K, and they are secreted concomitantly with ACTH-LI and beta-EP-LI. (eurekamag.com)
  • CRC cells treated with OXA and 5-Fu may release danger-associated molecular patterns (DAMPs), which play important roles in immunogenic tumor cell death. (nature.com)
  • Using several molecular and cellular techniques, we verified the aCGH findings and then extended our studies to additional EGFR mutant tumors. (pnas.org)
  • Our increasing understanding of these molecular pathways provides opportunities to specifically target tumor metabolism to overcome physiologic barriers and improve therapy. (pnas.org)
  • This adaptive response to low oxygen conditions may allow cells to spare molecular oxygen when it becomes scarce, making it available for other critical cellular processes ( 19 ). (pnas.org)
  • HBLAK may be valuable for evaluating the tumor specificity of novel cancer drugs, but may also be applied as an urothelial in vitro carcinogenesis model. (iospress.com)
  • hMLH1 and hMSH2 expression and BAX frameshift mutations in ovarian cancer cell lines and tumors. (oup.com)
  • One such hypothesis is based on the high susceptibility of stem cells to accumulate mutations, together with the existence of epigenetic changes that are essential for the initiation and development of tumourgenic behaviour. (oncotarget.com)
  • Multiple prospective trials have demonstrated an ≈75% response rate for patients whose tumors harbor these mutations ( 5 ). (pnas.org)
  • ATCC Tumor Cell Panels combine authenticated, well-characterized cell lines with mutation data from the Sanger Institute Catalogue of Somatic Mutations in Cancer (COSMIC) to create powerful tools for cancer research and drug discovery. (atcc.org)
  • We have established proliferating pure tumor cell cultures from cancer samples, followed by further expansion for patient-specific therapeutic purposes. (springer.com)
  • In this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines currently undergoing preclinical and clinical trials of several kinds of tumors are reviewed. (hep.com.cn)
  • By contrast, in metastatic tumors, the treatment of chemorefractory cases and maintenance therapy for chemosensitive cases are important issues in the development of a new therapeutic approach, which may be a different procedure from chemotherapeutic agents. (spandidos-publications.com)
  • It's easier to create mature cell populations for research or therapeutic use. (medica-tradefair.com)
  • This method provides a very convenient way to examine the effect of therapeutic drugs on the neuroendocrine tumor cells. (jove.com)
  • Oxaliplatin (OXA)- and 5-fluorouracil (5-Fu)-based FOLFOX chemotherapy is the first-line therapeutic regimen in the treatment of patients with advanced CRC. (nature.com)
  • An alternative approach to the problem of hypoxia is to exploit this unique situation by developing therapeutic strategies that rely on the presence of hypoxia to achieve tumor specificity ( 7 , 8 ). (pnas.org)
  • Full characterization of these lines is expected to provide the markers to find the relevant CTCs among the highly heterogeneous population observable in the context of tumor recurrence. (jcmtjournal.com)
  • Gliomas represent the most common primary brain tumor and are among the most aggressive of cancers. (hindawi.com)
  • Metastatic HNSCC cells lines were found to have vasculogenic properties similar to HUVEC cell lines when compared to cell lines from their corresponding primary tumour. (biomedsearch.com)
  • These results indicate that primary medulloblastomas express significant levels of TP73 isoforms, and suggest that they can modulate the survival and genotoxic responsiveness of medulloblastomas cells. (labome.org)
  • Skeletal metastatic disease is a deleterious consequence of dissemination of tumor cells from numerous primary sites, such as prostate, lung and breast. (diva-portal.org)
  • Directly derived from patient tumors without any genetic manipulation, these new products provide the assurance of primary cells with long-term reproducibility and scalability. (technologynetworks.com)
  • AMSBIO also offers a range of high quality cell culture media including Renaissance Essential Tumor Medium (RETM) and WIT culture media for the primary normal cell culture. (technologynetworks.com)
  • Our data showed that Salmonella species can upregulate TNF-α in primary monocytes, as well as in human promonocytic cells, through a released polypeptide(s). (asm.org)
  • A germ layer is a primary layer of cells that form during embryogenesis. (medica-tradefair.com)
  • Beyond primary cultures with their limitations in lifespan, interindividual heterogeneity and supply, few conditionally immortalized cell lines with limited applicability due to partial transformation or impaired differentiation capacity are available. (iospress.com)
  • We describe characteristics of the new spontaneously immortalized cell line HBLAK derived from a primary culture of uroepithelial cells. (iospress.com)
  • Primary cultures of urothelial cells, usually established from healthy ureters removed during tumor nephrectomy, provide one valuable model [ 1 ]. (iospress.com)
  • Treatment of three of these cell lines with the methylation-interfering agent 5-azacytidine induced ZAC re-expression, In addition, Northern blot and RNase protection assay analysis of ZAC expression in 23 unselected primary breast tumors showed a reduced expression in several samples. (cnrs.fr)
  • unfortunately, explanted primary prostate cells survive only short-term in culture, and rarely immortalize spontaneously. (elsevier.com)
  • Accordingly, cetuximab restored killing activity of sMICA-inhibited patient NK cells against cetuximab-coated primary HNSCC cells via ADCC in a dose-dependent manner. (frontiersin.org)
  • The ATCC Primary Cell collection includes quality primary cells, along with the media, reagents, and relevant information needed to support the successful culture of primary cells. (atcc.org)
  • [ 2 - 4 ] CTCs are described as cells, shed by primary or secondary tumors into vasculature, that keep circulating in the bloodstream of cancer patients. (jcmtjournal.com)
  • Current standard drug therapies involve the intravesical instillation of a chemotherapeutic agent or bacillus Calmette-Guérin (BCG) for non-muscle-invasive bladder tumors ( 6 ) and cisplatin-based systemic chemotherapy for locally advanced and metastatic bladder tumors. (spandidos-publications.com)
  • Must have received at least one dose of cycle 1 of a first-line platinum-based chemotherapy regimen for stage IV disease. (mainlinehealth.org)
  • Circulating tumor cell counts could be used to help clinicians choose between first-line hormone therapy (the recommendation option) or chemotherapy for patients with ER-positive, HER2-negative metastatic breast cancer. (ascopost.com)
  • In patients with discordant treatment recommendations between the clinician estimate and the circulating tumor cell count, front-line chemotherapy was associated with a significant (35%) decrease in the risk of death. (ascopost.com)
  • A phase III study by Bidard et al investigated whether circulating tumor cells could help physicians choose between hormone therapy or chemotherapy as front-line therapy for patients with estrogen receptor (ER)-positive, HER2-negative metastatic breast cancer. (ascopost.com)
  • In this phase III study, the researchers randomly assigned 761 patients to either a clinically driven treatment arm of hormone therapy or chemotherapy as decided by a physician based on clinical factors, or a circulating tumor cell-driven treatment arm. (ascopost.com)
  • In the latter patients, hormone therapy was administered if 7.5 mL of blood had less than 5 circulating tumor cells, and chemotherapy was administered if 7.5 mL of blood had 5 or more circulating tumor cells. (ascopost.com)
  • the remaining 33.3% were switched to chemotherapy based on a high circulating tumor cell count. (ascopost.com)
  • Among patients likely to receive chemotherapy by clinically driven choice, this treatment option was confirmed by a high circulating tumor cell count in 48.1% of the patients. (ascopost.com)
  • Overall survival rates at 24 months were 82.9% in patients treated with chemotherapy (and eventually followed by maintenance hormone therapy) vs 74.7% in patients treated with front-line hormone therapy. (ascopost.com)
  • In our study," Dr. Bidard continued, "not only have we demonstrated that basing the decision on [circulating tumor cell] count alone does not harm patients in the overall study population, but subgroup analyses show that in the 292 patients with discordant treatment recommendations, front-line chemotherapy was associated with a significant 35% decrease in the risk of death. (ascopost.com)
  • In non-small cell lung cancers with a programmed death-ligand 1 (PD-L1) tumor proportion score (TPS) of ≥50%, first-line treatment with the PD-1 inhibitor pembrolizumab improves survival compared to platinum-doublet chemotherapy. (asco.org)
  • Relapse after chemotherapy treatment depends on the cancer initiating cells (CICs). (oncotarget.com)
  • Especially in tumor types showing a high frequency of systemic disease, such as small cell lung cancer (SCLC), a small needle biopsy is procured first to confirm the diagnosis, and chemotherapy is started without any further invasive procedure. (jcmtjournal.com)
  • [ 1 ] Thus, the opportunity to obtain essential information from blood samples, as so-called liquid biopsies, would offer significant advantages.Non-invasive detection and monitoring of patient tumors, employing cell-free circulating tumor DNA (ctDNA) or circulating tumor cells (CTCs), have been employed for investigations into multiple tumor types. (jcmtjournal.com)
  • Abramova MV, Pospelova TV, Nikulenkov FP, Hollander CM, Fornace AJ Jr, Pospelov VA (2006) G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin. (springer.com)
  • AhR expression and function in the presence or absence of galangin, a second AhR inhibitor, α-naphthoflavone (α-NF), an AhR agonist, indole-3-carbinol, and a transfected AhR repressor-encoding plasmid ( FhAhRR ) were studied in Hs578T cells by western blotting for nuclear (for instance, constitutively activated) AhR and by transfection of an AhR-driven reporter construct, pGudLuc . (biomedcentral.com)
  • Here, we report a detailed homozygous deletion (HD) profiling for 246 critical loci on a panel of 89 tumor cell lines containing significant subsets of lung, ovarian and head and neck squamous cell carcinomas. (pasteur.fr)
  • Glioma cell line U87MG was obtained from the American Type Culture Collection (ATCC) (Manassas, VA), and glioma cell line 1321N1 was obtained from the European Collection of Cell Culture (ECACC) (Salisbury, Wiltshire, UK). (hindawi.com)
  • All cell lines used in this protocol can be obtained from the American Type Culture Collection (ATCC). (currentprotocols.com)
  • ATCC was entrusted with its first cell line in 1962 and has consistently attained the highest standards and used the most reliable procedures to verify every cell line since. (atcc.org)
  • The ATCC Cell Biology Collection is one of the largest bioresources in the world, and offers a complex array of human, animal, insect, fish and stem cell lines from which to choose. (atcc.org)
  • ATCC provides investigators with a comprehensive selection of animal cell lines from over 150 different species. (atcc.org)
  • ATCC maintains nearly 4,000 cell lines that are invaluable for public health research, including cancer models such as HeLa, OVCAR-3 and LNCaP. (atcc.org)
  • ATCC offers Tumor/Normal matched cell line pairs derived from the same donor, allowing researchers to compare the experimental results from tumor cell lines to that of their normal counterparts. (atcc.org)
  • METHODS: Two ovarian adenocarcinoma cell lines were used for the study: the first, OC-117-VGH, was deficient in estrogen receptors (ER)α and ERβ, and the second, OVCAR3, was positive for ERα and ERβ. (biomedsearch.com)
  • In fact, TNF receptors could not be demonstrated on L929rl cells, not even after low pH treatment and/or incubation with antiserum to TNF. (elsevier.com)
  • The number and binding affinity of TNF receptors were not consistently different between L929s and L929r2 cells. (elsevier.com)
  • These data suggest that IL-15 has an important role in activating an NK cell-mediated pathway that leads to the elimination of intracellular protozoans from the intestines, which is a previously unrecognized feature of NK cell function. (labome.org)
  • Results of previous studies demonstrated that phosphoinositide 3-kinase (PI3K)/Akt/mTOR signaling pathway may be activated in the great majority of NET cells. (enets.org)
  • In MM cells the anti-myeloma activity of pomalidomide may be mediated by the regulation of the mTOR pathway. (impactjournals.com)
  • A single injection of EBC-46 caused rapid inflammation and influx of blood, followed by eschar formation and rapid tumor ablation in a range of syngeneic and xenograft models. (plos.org)