• Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. (uchicago.edu)
  • Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor-initiating stem cells. (uchicago.edu)
  • Decreasing RT activity in cancer cells, by either LINE-1-specific RNA interference, or by RT inhibitory drugs, was previously found to reduce proliferation and promote differentiation and to antagonize tumor growth in animal models. (unife.it)
  • Remarkably, hybrid molecules fail to form in tumor cells treated with EFV under the same conditions that repress proliferation and induce the reprogramming of expression profiles of coding genes, microRNAs (miRNAs) and ultraconserved regions (UCRs). (unife.it)
  • Thus, the retrotransposon-encoded RT drives a previously unrecognized mechanism crucial to the transformed state in tumor cells. (unife.it)
  • We investigated the potential of lymphoblastoid cell lines (LCL) and Burkitt lymphoma (BL) cell lines to produce and respond to the cytotoxins, tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin (LT). Transformation in vitro of peripheral blood B cells by EBV from seven different donors resulted in spontaneous production of both LT (11,542 pg/ml +/- 7546, mean +/- SD) and, to a lesser extent, TNF-alpha (197 pg/ml +/- 174). (ox.ac.uk)
  • Large libraries of cancer cell lines - collections of cells that represent tumor types seen in cancer patients - can yield profound insights into tumors' unique genetic features and their sensitivities to current and potential treatments. (broadinstitute.org)
  • TNF-α binding to surface receptors elicits a wide array of biologic activities including: cytolysis and cytostasis of many tumor cell lines in vitro , hemorrhagic necrosis of tumors in vivo , increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils. (biolegend.com)
  • Soluble Axl (sAxl) is present in cell-conditioned medium of CUDC-305 (DEBIO-0932 ) tumor cells growing in vivo and in vitro and in the sera of humans mice and rats (23 50 However the identities of the sAxl-generating protease(s) and the mechanism(s) that account for this process remain unknown. (exposed-skin-care.net)
  • The growing interest in developing methods for personalized medicine, in which tumor cells from individual patients are tested for sensitivity to a panel of drugs 4 , has led to a need for more relevant, time-sensitive studies. (moleculardevices.com)
  • As marker of the viral gene expression SV40 was selected as its T- antigen ( viral tumor antigen ) gene expression can be clearly measured and distinguished from the host cell gene expression . (emf-portal.org)
  • Línea celular eucariótica obtenida en una fase estacionaria o de quiescencia que experimenta, en cultivo, una transformación hacia un estado de crecimiento descontrolado semejante a un tumor in vitro. (bvsalud.org)
  • This project is based on the hypothesis that LINE-1 elements constitute critical entities in glioma initiation and progression, by acting as a source of regulatory elements and coopted functional RNAs in tumor cells. (lu.se)
  • We will then use CRISPR approaches to silence/activateLINE-1 elements in glioma cell lines and interrogate the consequences of LINE-1 modulation on tumor physiology. (lu.se)
  • The aim of this study was to analyze the effects of gga-miR-155 on the proliferation, apoptosis and invasiveness of an MDV-transformed lymphocyte line MSB1 and elucidate the underlying mechanisms. (biomedcentral.com)
  • While overexpression of gga-miR-155 increased proliferation, decreased the proportion of G1 phase cells relative to that in S and G2 phases, reduced apoptosis rates and increased invasiveness. (biomedcentral.com)
  • The gga-miR-155 promotes the proliferation and invasiveness of the MDV-transformed lymphocyte line MSB1 and inhibits apoptosis by targeting the RORA gene. (biomedcentral.com)
  • To this end, we overexpressed and inhibited gga-miR-155 in an MDV-transformed cell line using mimics and inhibitors respectively, and analyzed their growth, proliferation, apoptosis and invasiveness to explore the possible role of gga-miR-155 in MDV-mediated tumorigenesis. (biomedcentral.com)
  • Furthermore, we predicted and demonstrated that Retinoid Acid Receptor-Related Orphan Receptor Alpha (RORA) is one of the targets of gga-miR-155, and the gga-miR-155 regulated the proliferation, cell cycle, apoptosis and invasiveness of MSB1 cells by targeting RORA. (biomedcentral.com)
  • A critical event in B cell immortalization by Epstein-Barr virus (EBV) is the establishment of an autocrine loop where cells produce a growth factor which supports their own proliferation. (ox.ac.uk)
  • Proliferation of an LCL and a 'group III' BL cell line in vitro was via an autocrine loop since inhibition of LT reduced proliferation. (ox.ac.uk)
  • In contrast to these observations with p55 TNF-R antibodies, two out of six of the 'group III' BL lines (Jijoye and Oba) only expressed the p75 TNF-R and proliferation of these cells could only be blocked by the antagonistic anti-p75 TNF-R antibody UTR-1. (ox.ac.uk)
  • Reducing IRS-4 expression using small interfering RNA (siRNA) in established Ad5E1A-expressing cell lines decreases the activation of Akt and cellular proliferation. (ox.ac.uk)
  • Cell proliferation was assessed by CCK-8 assay. (medscimonit.com)
  • Results showed that puerarin promoted the apoptosis and inhibited the proliferation of HLF1 cells. (medscimonit.com)
  • Puerarin regulated the proliferation and apoptosis of pulmonary fibrosis cells, and affected the secretion of inflammatory cytokines. (medscimonit.com)
  • Receptor tyrosine kinases (RTKs) play fundamental tasks in varied cell functions including proliferation differentiation survival migration and rate of metabolism (16). (exposed-skin-care.net)
  • Spanish and Italian researchers have proven that when honey from strawberry trees, a product typical of Mediterranean areas, is added to colon cancer cells grown in the laboratory, cell proliferation is stopped. (agenciasinc.es)
  • The results, published in the Journal of Functional Foods, show that strawberry tree honey is capable of inhibiting the proliferation of tumour cells cultivated in laboratory plates - more specifically, those of a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo), widely used to investigate this type of tumour. (agenciasinc.es)
  • It also suppresses the receptor of the epidermal growth factor called EGFR/HER2 and its signalling pathways, which could be an attractive target in cancer therapies because of their important role in the processes of cell survival and proliferation, as well as in those of apoptosis and metastasis. (agenciasinc.es)
  • Strawberry tree honey is capable of inhibiting the proliferation of tumour cells on a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo). (agenciasinc.es)
  • Cell apoptosis was measured by flow cytometry, TUNEL assay, and detection of caspase 3 and Bcl-2. (medscimonit.com)
  • found that FWGE can promote apoptosis in different types of cancer cell lines such as SNU-5, MKN-45, SNU-620, SNU-1, and SNU-16. (hindawi.com)
  • FWGE has significant antiproliferative effects and kills tumour cells by the induction of apoptosis via the caspase-poly (ADP-ribose) polymerase pathway [ 9 ]. (hindawi.com)
  • it inhibits cell migration, reduces the ability to form colonies and induces apoptosis or programmed cell death through the modulation of other key genes (p53, caspase-3, c-PARP) and various apoptotic factors," says Maurizio Battino, coordinator of the research. (agenciasinc.es)
  • 40 pg/ml LT) which had maintained the original BL biopsy cell phenotype in vitro. (ox.ac.uk)
  • These data suggest that LT is an autocrine growth factor for lymphoblastoid cells, and BL cell lines which display an LCL phenotype. (ox.ac.uk)
  • We conclude that the association and altered regulation of IRS proteins by Ad5E1A contribute to the adenovirus-transformed phenotype and modulates viral infection in an Akt-dependent manner. (ox.ac.uk)
  • The paper, titled "Hypoxic Induction of Exosome Uptake through Proteoglycan-Dependent Endocytosis Fuels the Lipid Droplet Phenotype in Glioma" and published at Molecular Cancer Research, shows that exosome-like extracellular vesicles (EVs) may serve anabolic functions by transforming hypoxic, patient-derived human glioblastoma cell lines into a lipid loaded phenotype. (lu.se)
  • In this study, evidence shows that EVs can fuel hypoxic glioma cells to acquire a lipid droplet (LD+) phenotype and such effect is associated with increased EV internalization through a hypoxia-sensitive mechanism dependent on heparan sulfate proteoglycan (HSPG) receptor and lipid raft-mediated endocytosis. (lu.se)
  • Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. (nih.gov)
  • Combined treatment of FWGE and 5-fluorouracil or dacarbazine resulted in a synergistic effect in the HCR-25 human cancer cell line and B16 murine melanoma cell line [ 6 ]. (hindawi.com)
  • The human lung fibroblasts cell line HLF1 was treated with different concentrations of puerarin in different groups for various times. (medscimonit.com)
  • Additionally, the introduction of a SV40 origin of DNA replication defective mutant in human fibroblasts (so called HAL cells ) is known to increase the lifespan up to immortality . (emf-portal.org)
  • The exposure of SV40 - transformed human fibroblasts to an electromagnetic field showed increased levels of virally derived mRNA and protein of the T- antigen . (emf-portal.org)
  • that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
  • The PRMT5 inhibitor EPZ015666 is effective against HTLV-1-transformed T-cell lines in vitro and in vivo . (bvsalud.org)
  • Differential response of dendritic cells to human metapneumovirus and respiratory syncytial virus. (microbiologyresearch.org)
  • constitutively released by murine main cells such as dendritic and transformed cell lines. (exposed-skin-care.net)
  • Wutz, A. Haploid mouse embryonic stem cells: rapid genetic screening and germline transmission. (nature.com)
  • Leeb, M. & Wutz, A. Derivation of haploid embryonic stem cells from mouse embryos. (nature.com)
  • Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. (nature.com)
  • Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. (nature.com)
  • Androgenetic haploid embryonic stem cells produce live transgenic mice. (nature.com)
  • Genetic modification and screening in rat using haploid embryonic stem cells. (nature.com)
  • Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes. (nature.com)
  • Derivation and differentiation of haploid human embryonic stem cells. (nature.com)
  • Multimeric alpha-lactalbumin killed all transformed, embryonic, and lymphoid cells tested but spared mature epithelial elements. (lu.se)
  • Clinical research had demonstrated the therapeutic benefits of interventions using adult stem cells rather than embryonic cells, a direction that guaranteed respect for human dignity, even at the embryonic stage. (who.int)
  • hPSC-enriched essential genes mainly encode transcription factors and proteins related to cell-cycle and DNA-repair, revealing that a quarter of the nuclear factors are essential for normal growth. (nature.com)
  • In this video, Prof. Erwin Schoof, Associate Professor, Cell Diversity Lab, Technical University of Denmark, explains how the Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer is revolutionizing single-cell proteomics, enabling the Cell Diversity Lab to characterize low abundant proteins such as transcription factors, kinases, and epigenetic regulators which were previously undetectable by mass spectrometry. (selectscience.net)
  • Several studies shown that Axl could mediate cell adhesion and aggregation through homotypic ectodomain associations (9 23 Both CUDC-305 (DEBIO-0932 ) murine and human being Axl proteins undergo proteolytic processing to yield a soluble form of this molecule. (exposed-skin-care.net)
  • To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
  • The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
  • We also illustrate a novel assay that can identify B cells destined to undergo transformation as early as three days after infection. (jove.com)
  • Cell transformation and gene expression induced by metal working fluid in BALB/c-3T3 cells. (cdc.gov)
  • These results indicate that MWF is capable of inducing morphological transformation in BALB/c-3T3 cells and that alteration in c-jun and c-fos expression in associated with MWF-induced transformation. (cdc.gov)
  • Cellular transformation/tumorigenicity assays using cultures of cells in semi-solid media (soft agar or Matrigel) has been well established for cancer research 1,2,5 . (moleculardevices.com)
  • Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs. (uchicago.edu)
  • Partial transcription of murine type-C viral genomes in BALB/c cell lines. (microbiologyresearch.org)
  • This study was performed in order to examine the effects of an extremely low frequency magnetic field on viral gene expression in human host cells . (emf-portal.org)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
  • Endogenous virus-specific RNA in uninfected BALB/c cell line JLS-V9. (microbiologyresearch.org)
  • To study the transforming potential of MWF, BALB/c-3T3 cells were exposed to MWF at varying concentrations for 24 hours. (cdc.gov)
  • A distinct class of inducible murine-type-C viruses that replicates in the rabbit SIRC cell line. (microbiologyresearch.org)
  • [ 22 ] resulting in a positive feedback loop of T-cell activation and inflammatory cytokine release, a murine model study has suggested that the cytokines and factors that mediate the severity of CRS, IL-6, IL-1, and nitric oxide are not produced by the CAR-T cells but by recipient macrophages, and can be reversed by IL-1 blockade. (medscape.com)
  • Finally, we will use novel biochemical methods to explore the mechanisms underpinning howLINE-1 RNAs control transcriptional and post-transcriptional programs in glioma cells. (lu.se)
  • The methods can include a variety of mass spectrometry tools, cell culture, tissue sectioning, mathematical mass balance modelling, and isotope geochemistry. (lu.se)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • Using our recently established haploid human pluripotent stem cells (hPSCs), we generated a genome-wide loss-of-function library targeting 18,166 protein-coding genes to define the essential genes in hPSCs. (nature.com)
  • Fig. 2: Analysis of cell-essential genes. (nature.com)
  • None of the genes studied were amplified in these transformed cells. (cdc.gov)
  • Treatment with honey stops the tumour cells cycle by regulating some genes (cyclin D1, CDK2, p27Kip. (agenciasinc.es)
  • Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
  • Polymorphisms in transforming growth factor-beta-related genes ALK1 and ENG are associated with sporadic brain arteriovenous malformations. (medlineplus.gov)
  • Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines. (hsanmartino.it)
  • A multi-center research team has now greatly augmented this cancer research resource by incorporating new cell lines and adding new data spanning the molecular spectrum from sequence to expression to protein. (broadinstitute.org)
  • This research will transform our understanding of the underlying molecular mechanisms driving glioma initiation and progression and thereby generate much-needed new hypotheses on pathological processes in this devastating disease. (lu.se)
  • Exposure of simian virus-40-transformed human cells to magnetic fields results in increased levels of T-antigen mRNA and protein med. (emf-portal.org)
  • immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
  • To prepare spheroid cultures in semi-solid media, human colon carcinoma HCT116 cells were pre-mixed with a solution of 4.25 mg/mL cold Matrigel (Corning) diluted in growth media and plated into 96-well half-area plates (Greiner) at a density of \~500 cells/well for a total volume of 25 μL. (moleculardevices.com)
  • The cytotoxicity and anti-tumour effects of strawberry tree honey in relation to colon cancer lines increased with the amount and time of treatment. (agenciasinc.es)
  • None of these effects was observed when honey was applied to healthy cell lines," the authors point out, noting the anticarcinogenic potential of this natural product, but insisting on the need for new studies with colon cancer in vivo models to confirm its chemopreventive effects. (agenciasinc.es)
  • We therefore chose to study CysLT1 in colon cancer specimens and in non-transformed and colon cancer cell lines. (lu.se)
  • A common heterophilic ligand for these RTK family members is definitely Gas6 a vitamin K-dependent protein that is widely secreted by most cells including the lungs intestine Serping1 and vascular endothelium (43). (exposed-skin-care.net)
  • The development of atherosclerosis is complicated, but the primary event seems to be repeated, subtle injury to the artery's inner lining (endothelium), through various mechanisms. (msdmanuals.com)
  • Cell Line, Transformed" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • This led to other relevant results, such as the reduction of some transcription factors, the inhibition of the activity of certain enzymes and the decrease of mitochondrial respiration and glycolysis of tumour cells. (agenciasinc.es)
  • The second is PRISM , a system that uses genetically-barcoded versions of the CCLE cell lines to identify biomarkers that could be used to predict tumors' responses to different drug compounds. (broadinstitute.org)
  • Lymphotoxin acts as an autocrine growth factor for Epstein-Barr virus-transformed B cells and differentiated Burkitt lymphoma cell lines. (ox.ac.uk)
  • Furthermore, although both TNF-R are increased on the surface of these cells, this autocrine growth signal is mediated principally through binding to the p55 TNF-R. (ox.ac.uk)
  • Transforming growth factor-β (TGF-β) is an important pro-fibrotic growth factor implicated in airway remodeling and pulmonary fibrosis ( 6-9 ). (atsjournals.org)
  • The transforming growth factor-β (TGF-β) signaling pathway has been frequently implicated in breast cancer. (aacrjournals.org)
  • Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. (jci.org)
  • Compared with adherent cells grown in 2D monolayers, 3D growth conditions are believed to more accurately reflect the natural environment of cancer cells and span the gap between 2D cultures and animal studies 3,5 . (moleculardevices.com)
  • In this study, we describe a method compatible with highthroughput screening, in which compound effects on cell growth in semi-solid media were measured and quantitated using high-content imaging and 3D analysis. (moleculardevices.com)
  • Hereditary hemorrhagic telangiectasia: an update on transforming growth factor beta signaling in vasculogenesis and angiogenesis. (medlineplus.gov)
  • Prolonged expression of Ad5E1A13S is required for the observed dramatic increase in the levels of IRS-4 mRNA and protein in Ad5E1-transformed human cell lines. (ox.ac.uk)
  • However, both the mRNA and the protein it produces have been changed from the original version in the virus with the intent to increase rate of production of the protein in an infected cell and the durability of both the mRNA and the spike protein it codes for. (theepochtimes.com)
  • In this study, we found that NS1 protein inhibits IRF-3-dependent gene transcription in constitutively active IRF-3 overexpressing cells, demonstrating that NS1 directly targets IRF-3. (microbiologyresearch.org)
  • This information has transformed how cancer scientists characterize drug targets and measure drug activity. (broadinstitute.org)
  • Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)
  • For these short fibers, which can be fully engulfed by lung cells and do not dissolve in airway fluids in less than a few weeks, their clearance will be similar to other mineral and vitreous particles. (cdc.gov)
  • While investigating the effect of human milk on bacterial adherence to a human lung cancer cell line, we were surprised to discover that the milk killed the cells. (lu.se)
  • In 2012, the CCLE collaborators took a deep dive into the genomic features and drug sensitivities of these cells, cataloging gene expression, chromosomal copy number, and targeted gene sequencing data from all 947 lines and a number of drug-response profiles. (broadinstitute.org)
  • Cell Stem Cell 19 , 569-572 (2016). (nature.com)
  • Cell Stem Cell 9 , 563-574 (2011). (nature.com)
  • Cell Stem Cell 14 , 404-414 (2014). (nature.com)
  • The apple stem cell moisturizer not only smells great, but it also protects, prevents, and repairs aging skin cells by replacing damaged cells with new, healthy ones. (planetbeach.com)
  • Plant stem cells have age fighting and skin renewing properties that'll gradually make your skin softer and youthful. (planetbeach.com)
  • Moisturize with the apple stem cell moisturizer to protect your skin from aging. (planetbeach.com)
  • The terms cytokine storm and CRS have both been used to describe similar syndromes of systemic inflammation that are associated with a variety of diseases and treatments, such as graft versus host disease (GVHD) after allogeneic stem cell transplant, macrophage activation syndrome (MAS)/hemophagocytic lymphohistiocytosis (HLH), idiopathic multicentric Castleman disease (iMCD), COVID-19, and as an adverse event associated with several monoclonal antibody infusions. (medscape.com)
  • The WT cells are from a cell line generated (for this study) from hBcl-2 transgenic mice (Strasser et al. (nih.gov)
  • CD44 has functional roles in cell migration, lymphocyte homing and adhesion during hematopoiesis and lymphocyte activation. (bdbiosciences.com)
  • Pearson's research led to a collaboration with a fellow postdoc, Georges Kohler, and supervisor César Milstein to develop monoclonal antibodies specific for cell surface antigens. (wikipedia.org)
  • The expression level of gga-miR-155 was manipulated in MSB1 cells using specific mimics and inhibitors. (biomedcentral.com)
  • Furthermore, gga-miR-155 directly targeted the RORA gene and downregulated its expression in the MSB1 cells. (biomedcentral.com)
  • Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway. (ox.ac.uk)
  • B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
  • These results suggest that the oral administration of antigens generates antigen specific TGF-beta1 secreting Th3 cells of presumed mucosal origin that represent a distinct lineage of T cells. (jci.org)
  • Since antigen-specific TGF-beta1 secreting cells localize to the target organ and then suppress inflammation in the local microenvironment, oral tolerization with self antigens may provide a therapeutic approach for the treatment of cell-mediated autoimmune disease which does not depend upon knowledge of the antigen specificity of the original T cell clone triggering the autoimmune cascade. (jci.org)
  • cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)
  • Blood Cells Mol Dis 2010(3): 246-65 [ PubMed abstract ]. (lu.se)
  • Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain. (medlineplus.gov)
  • Cells were lysed and chromatin was digested with HindIII as described previously (Lieberman-Aiden et al. (nih.gov)
  • Can we apply strategies used by extremophiles to improve mammalian cell and tissue storage? (researchgate.net)
  • Dr CHAUHAN (India)1 welcomed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation. (who.int)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • The assay requires cells to grow in an anchorage independent manner, which is a hallmark of cancer cells. (moleculardevices.com)
  • In an alternative assay, cells were fixed for 1 hour using a 4% formaldehyde solution, washed 3x with PBS by removing half of the volume each time. (moleculardevices.com)
  • In animals with experimental autoimmune disease, a major mechanism of oral tolerance triggered by oral administration of antigen involves the induction of regulatory T cells that mediate active suppression by secreting the cytokine TGF-beta 1. (jci.org)
  • Cytokine release syndrome (CRS) is a potentially life-threatening condition that results from the pathologic over-activation of T cells, leading to hypersecretion of cytokines by T cells and other immune cell types. (medscape.com)
  • Mild CRS after CAR-T cell infusion often resolves without anti-cytokine intervention and patients are supported with antipyretics and intravenous fluids as needed. (medscape.com)
  • The gga-miR-155 is downregulated in the MDV-infected chicken tissues or lymphocyte lines, although its exact role in tumorigenesis remains unclear. (biomedcentral.com)
  • ATP-citrate lyase is essential for high glucose-induced histone hyperacetylation and fibrogenic gene upregulation in mesangial cells. (uchicago.edu)
  • Chronic bronchitis is another chronic obstructive disease of the airways in which inflammation is a continuous process probably commencing with an increase in inflammatory cells ( 4 ) and followed by airway remodeling with extracellular matrix deposition on the airways wall ( 5 ). (atsjournals.org)