• Different viruses have been implicated in the pathogenesis of LGL leukemia like: Human T-cell leukemia - lymphoma virus-I-II (HTLV I-II), Epstein-Barr virus ( EBV ), Human immunodeficiency virus ( HIV ) and Human Herpes virus type-8 (HHV8). (doctorslounge.com)
  • JAK inhibitors, currently used in the treatment of rheumatoid arthritis and some other hematological diseases, could potentially improve the treatment of various NK-cell malignancies," says MD/PhD student Olli Dufva who is the first author in the publication. (helsinki.fi)
  • CD4CAR is a novel development for the treatment of CD4+ T-cell malignancies. (stonybrook.edu)
  • These malignant entities are significantly more difficult to treat in comparison to B-cell malignancies. (stonybrook.edu)
  • Furthermore, T-cell malignancies almost exclusively have poorer outcomes with few exceptions, lower response rates, shorter times of disease control and survival. (stonybrook.edu)
  • As a result, the standard of care for T-cell malignancies is not well-established and the only potential curative approach is allogeneic blood and marrow transplant (BMT) for which patients need to achieve complete disease control and to have suitable marrow donors. (stonybrook.edu)
  • The WHO modification of the REAL classification of NHL is based on morphology and cell lineage. (medscape.com)
  • Leukemic cells are invariably present in samples of peripheral blood to a variable extent. (wikipedia.org)
  • Circulating leukemic NK cells can range from few percent to more than 80% of all leukocytes. (ispub.com)
  • Once these cells are infused back into a patient's body through an IV, they multiply and attack tumor cells efficiently throughout the body. (stonybrook.edu)
  • By creating an antibody that recognizes CD19 and then connecting that antibody to T cells, the researchers created in CTL019 cells a sort of guided missile that locks in on and kills B cells, thereby attacking B-cell leukemia. (technologynetworks.com)
  • The immunomodulating drugs did not interfere with the CTL019 therapy's anti-leukemia benefits, which persisted for 6 months after the infusion of cell therapy. (oncologynurseadvisor.com)
  • However, cancer cells fly under the radar of immune surveillance, evading detection by T cells. (technologynetworks.com)
  • The new approach custom-designs T cells to "see" and attack the cancer cells. (technologynetworks.com)
  • This persistence is essential, because the engineered T cells remain in the patient's body to protect against a recurrence of the cancer. (oncologynurseadvisor.com)
  • Precision Cancer Medicine Precision medicine enables cancer specialists to identify and target cancer cells. (osu.edu)
  • As described in the journal Cancer Cell this month the UCSF te. (bio-medicine.org)
  • As described in the journal Cancer Cell this month, the UCSF team found that the pool of cells from which oligodendroglioma tumors emerge normally divide "asymmetrically" by splitting into two unequal parts like giving birth to fraternal twins who look different and have distinct fates. (bio-medicine.org)
  • When these normal cells transform into cancer cells, they switch gears and begin dividing symmetrically, essentially giving birth to identical twins instead. (bio-medicine.org)
  • Childhood cancer arises from the primitive cells, thus the types of cancer found in children is significantly different than cancer in adults. (dmoztools.net)
  • Brain tumor specimens taken from neurosurgery cases at the University of California, San Francisco (UCSF) Medical Center has given scientists a new window on the transformation that occurs as healthy brain cells begin to form tumors. (bio-medicine.org)