• As it is in much of life, the aging process isn't kind to an important type of stem cell that has great therapeutic promise. (sciencedaily.com)
  • Unfortunately stem cell therapeutics don't have high success rates partly because the cells are not mature and fully functional. (medgadget.com)
  • Induced pluripotent stem cell-derived cardiomyocytes beating in substrate. (medgadget.com)
  • Hematopoietic stem cell transplantation (HSCT) involves the transfer of HSPCs from a donor to patients with both benign and malignant diseases. (phys.org)
  • Hans Keirstead and his colleagues in the Reeve-Irvine Research Center at UC Irvine have found that a human embryonic stem cell-derived treatment they developed was successful in restoring the insulation tissue for neurons in rats treated seven days after the initial injury, which led to a recovery of motor skills. (sci-info-pages.com)
  • The findings point to the potential of using stem cell-derived therapies for treatment of spinal cord damage in humans during the very early stages of the injury. (sci-info-pages.com)
  • It is anticipated that the stem cell treatment in humans will occur during spinal stabilization at the acute phase, when rods and ties are placed in the spinal column to restabilize it after injury. (sci-info-pages.com)
  • Hematopoietic stem cell transplantation (HSCT) is a broad term that covers the transplantation of blood progenitor/stem cells from any source. (drugdiscoverynews.com)
  • The consumption of alcohol is always a controversial topic and a Reuter's article explored how drinking can damage stem cell DNA. (mercola.com)
  • Harvard Stem Cell Institute (HSCI) scientists have found a way to both make more energy-burning human brown fat cells and make the cells themselves more active, a discovery that could have therapeutic potential for diabetes, obesity, and other metabolic diseases. (scitechdaily.com)
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)
  • More specifically, they are looking at the lungs - according to Signe Kjelstrup, who is heading the team, making fuel cells in the shape of lungs could cut down on the amount of expensive catalysts needed, such as platinum, while increasing efficiency. (inhabitat.com)
  • But what makes the shape of the lung benefical to the efficiency of fuel cells? (inhabitat.com)
  • The X-BACS Technology provides a highly-purified preparation of target cells, with a high recovery efficiency and cell viability. (corning.com)
  • In partnership with AESP: The increasing roles of DERs, connected technology and Big Data are driving rapid change in energy efficiency. (energycentral.com)
  • But improved energy efficiency may also have a positive impact on the transition from fossil fuel to renewable energy. (energycentral.com)
  • One property this structure gives solar cells is excellent electron richness, which in this case allows electrons to move more easily from the perovskite layer to subsequent layers, improving the resiliency and efficiency of converting solar energy to electricity. (energycentral.com)
  • Developing more efficient solar arrays increases their energy efficiency. (energycentral.com)
  • Design rules for minimizing voltage losses in high-efficiency organic solar cells. (nature.com)
  • Non-fullerene acceptors with branched side chains and improved molecular packing to exceed 18% efficiency in organic solar cells. (nature.com)
  • Tandem organic solar cell with 20.2% efficiency. (nature.com)
  • Organic and solution-processed tandem solar cells with 17.3% efficiency. (nature.com)
  • Mitsubishi Electric Corp., a global manufacturer of electrical and electronic equipment, has achieved a record photoelectric conversion efficiency rate of 18% in a 150-mm square practical-use multi-crystalline silicon solar cell. (solarindustrymag.com)
  • Solar cells made with low-cost, nontoxic copper-based quantum dots can achieve unprecedented longevity and efficiency, according to a study by Los Alamos National Laboratory and Sharp Corporation. (phys.org)
  • The new solar cells were certified by the National Renewable Energy Laboratory (NREL) and demonstrated a record power-conversion efficiency for this type of devices," according to Victor Klimov of Los Alamos, director of the Center for Advanced Solar Photophysics (CASP), a DOE Energy Frontier Research Centers (EFRC). (phys.org)
  • The researchers found that an exposure of 24 hours led to sustained improvements in cell fitness and transplantation efficiency after ex vivo culture, with improved rates of blood cell function in mouse models. (phys.org)
  • While numerous advances have been made over past decades to improve safety and efficiency of HSPC transplantation and ex vivo gene therapy, constraints in cell quantity and graft success continue to limit outcomes," said senior author Peter Kurre, MD, Director of the Pediatric Comprehensive Bone Marrow Failure Center at CHOP. (phys.org)
  • Now the researchers have enhanced the perovskite crystallization process and developed highly transparent window layers, resulting in tandem solar cells with an efficiency of 29.2% on a surface of 1 cm 2 . (epfl.ch)
  • The cell viability and apoptosis were determined by CCK-8 assay and acridine orange/ethidium bromide (AO/EB) fluorescence staining assay. (greenmedinfo.com)
  • Due to their reduced cell density, dead cells can be removed to optimize viability before delivery. (labmanager.com)
  • Now, scientists at the University of Tsukuba have engineered graphene-based membranes that block this fuel crossover while still allowing high proton conductivity, marking a leap forward for carbon-neutral fuel cell viability. (nanowerk.com)
  • The results showed that increasing concentrations of MGO led to glycation , the accumulation of advanced glycation end-products, and decreasing cell viability in all cell lines . (bvsalud.org)
  • Cite this: Ethnicity Increases Impact of Common Dementia Risk Factors - Medscape - Oct 24, 2023. (medscape.com)
  • Cells;12(9)2023 04 23. (bvsalud.org)
  • Researchers who looked at the effect of aging on induced pluripotent stem cells (iPSCs) found that genetic mutations increased with the age of the donor who provided the source cells, according to study results. (sciencedaily.com)
  • Researchers at the Scripps Translational Science Institute (STSI) and The Scripps Research Institute (TSRI) who looked at the effect of aging on induced pluripotent stem cells (iPSCs) found that genetic mutations increased with the age of the donor who provided the source cells, according to study results published by the journal Nature Biotechnology . (sciencedaily.com)
  • Researchers found that iPSCs made from donors in their late 80s had twice as many mutations among protein-encoding genes as stem cells made from donors in their early 20s. (sciencedaily.com)
  • Unexpectedly, iPSCs made from blood cells donated by people over 90 years old actually contained fewer mutations than what researchers had expected. (sciencedaily.com)
  • Researchers said the reason for this could be tied to the fact that blood stem cells remaining in elderly people have been protected from mutations over their lifetime by dividing less frequently. (sciencedaily.com)
  • In order to bring this ground-breaking treatments to many patients as quickly as possible, researchers and manufacturers need to improve on manual, time-consuming processes. (corning.com)
  • Researchers at Michigan Tech and Harvard Medical School have developed a new way to create cardiomyocytes from induced pluripotent stem cells (iPSCs), for improved cardiac cell therapy. (medgadget.com)
  • iPSCs show significant potential for cardiac regenerative medicine, as researchers can use biochemical cues to "program" them into a cardiomyocyte-like cell, which shows regenerative efficacy in damaged cardiac muscle. (medgadget.com)
  • Rather than focusing on biochemical cues, these researchers looked at modifying the 3D environment of the cells, with a view to creating an environment more like that found in the heart. (medgadget.com)
  • The researchers plan to test the cells in an animal model of cardiac disease, and also investigate the potential of enhancing electrical conductivity between the cells, to facilitate the cell-cell communication that occurs in the heart. (medgadget.com)
  • A team of researchers led by the University of California San Diego has created a device that measures how 'sticky' cancer cells are, which could improve prognostic evaluation of patient tumors. (news-medical.net)
  • Researchers found that weakly adherent cells migrated and invaded other tissues more than the strongly adherent cells from the same tumor. (news-medical.net)
  • Researchers from the University of Newcastle found raised levels of specific immune cells in asymptomatic people with Covid, in a study published in the journal Nature Medicine . (nursinginpractice.com)
  • The researchers sequenced over 800,000 immune cells in blood analysed from 130 people in the UK who were infected with Covid-19. (nursinginpractice.com)
  • In people with no symptoms, the researchers found increased levels of immune cells such as B cells and helper T cells. (nursinginpractice.com)
  • The researchers also found increased numbers of cells that cause inflammation, such as monocytes and killer T cells. (nursinginpractice.com)
  • That's is the conclusion of first-of-a-kind study by researchers at the Mayo Clinic, which found that mice lived about 25 percent longer on average if so-called "senescent" cells were cleared out from their bodies. (technologyreview.com)
  • Imperial researchers have found a new cell mechanism that could be used to target tumours in the future. (imperial.ac.uk)
  • Conducting studies in mice with atherosclerosis, the researchers showed that loss of a candidate gene at this locus leads to impaired "efferocytosis" - from the Latin for "take to the grave" - the process by which dead or necrotic cells are removed. (stanford.edu)
  • Stanford Medicine researchers showed that five minutes a day of breathing exercises can reduce overall anxiety and improve mood. (stanford.edu)
  • A readily available, inexpensive, small molecule drug can improve the fitness of hematopoietic stem and progenitor cells (HSPCs) that are modified outside the body, potentially improving the success of procedures such as ex vivo gene therapy, according to a new study by researchers at Children's Hospital of Philadelphia (CHOP). (phys.org)
  • For this reason, researchers have sought to better understand HSPC programming and signaling so that every attempt could be made to maintain cell health ahead of transplant. (phys.org)
  • Additionally, the researchers found that blocking nSMase2 in human CD34+ cells leveled disparities in how well the cells of varying HLA types performed after transplantation into mice. (phys.org)
  • Drilling down on the mechanisms behind these phenomena, the researchers determined that blocking nSMase2 activates an integrated stress response, effectively putting the cells into a state of quiescence, where they are protected from external stressors. (phys.org)
  • Researchers should continue to explore the potential of this small molecule drug in improving ex vivo HSPC culture and transplantation. (phys.org)
  • The researchers injected these cells into rats that had experienced a partial injury to the spinal cord that impairs walking ability - one group seven days after injury and another 10 months after injury. (sci-info-pages.com)
  • Nanowerk News ) Researchers have made significant progress in developing advanced fuel cell membranes that could enable greener technologies like direct methanol and direct formic acid fuel cells. (nanowerk.com)
  • The researchers suggest that specialized fuel cell membranes integrating functionalized graphene could also be applied to other chemical fuels like ammonia and hydrogen peroxide. (nanowerk.com)
  • A team of researchers has discovered a way to increase energy-burning human brown fat cells and to make them more active, a discovery that could have therapeutic potential for diabetes, obesity, and other metabolic diseases. (scitechdaily.com)
  • The researchers determined that a whole suite of genes help determine how much UCP1 a brown fat cell will produce once it has matured, and those genes control UCP1 production in different ways. (scitechdaily.com)
  • Researchers at EPFL have identified the cause of degradation and developed a technique to improve stability, bringing us closer to widespread adoption of these cost-effective and efficient solar cells. (epfl.ch)
  • Based on their properties, researchers have also been exploring CNTs potential for biological and biomedical applications as drug delivery systems, substrate for cells growth in tissue regeneration, therapeutic agents, or as vectors for gene transfection. (cdc.gov)
  • An abnormal increase in blood glucose may be due to a defect in insulin self-secretion caused by the immune system (type 1 diabetes mellitus, T1DM), or resistance to the cellular effects of insulin, as well as insufficient insulin secretion (type 2 diabetes mellitus, T2DM) [ 1 ]. (hindawi.com)
  • This guidance, together with the guidance on allogeneic pancreatic islet cell transplantation for type 1 diabetes mellitus (IPG257) replaces the previous interventional procedures guidance on pancreatic islet cell transplantation (IPG13). (nice.org.uk)
  • Their analysis led the team to another critical finding: weakly adherent cells have a unique genetic signature that identifies them and enables them to migrate and invade faster. (news-medical.net)
  • To prove that, the team relied on genetic engineering, creating breeds of mice in which they could tag, and selectively destroy, any cell expressing a biomarker of senescence. (technologyreview.com)
  • Although the genetic method would be hard to use in people, drugs could be developed to kill senescent cells. (technologyreview.com)
  • Due to a genetic defect, the body's ability to dispose of its daily tonnage of dead cells gets damaged, and as a result the body's garbage - in the form of old cells and debris - starts to build up in the walls of its blood vessels. (stanford.edu)
  • Mice with this genetic variation showed an increase in buildup of these dead cells, further advancing their atherosclerosis as opposed to those that did not have the genetic variation. (stanford.edu)
  • When enough cells are available for modification, this strategy has proven to be a powerful platform for treating genetic blood disorders, including sickle cell disease and beta thalassemia. (phys.org)
  • Our lab aims to dissect the complex tumour-microbe-immune interactions in order to identify ways to improve BCT with further genetic modifications or co-therapies. (york.ac.uk)
  • We also investigate whether immune tolerance treatment with GAD-alum affects T-cells in nondiabetic children at increased genetic risk of T1D prospectively followed in longitudinal studies. (lu.se)
  • Cell based immunotherapy research continues to advance and novel ideas for developing cancer therapies, such as chimeric antigen receptor (CAR-T) therapies are now a reality. (corning.com)
  • Still, developing and manufacturing high-quality clinical-grade cell therapies for large scale patient use remains a challenge. (corning.com)
  • The Corning X-SERIES Cell Separation Platform provides a comprehensive and commercially viable, semi-automated manufacturing and controlled solution for the development of cell therapies. (corning.com)
  • Harness the full potential of evolving immune cell therapies, accelerate your research pipeline, and improve patient access to life-changing treatments. (corning.com)
  • Other groups are also working on cell therapies for the treatment of poor graft function after HSCT. (drugdiscoverynews.com)
  • Many gene therapies and viral vaccines rely on recombinant adeno-associated virus (rAAV) to deliver DNA to cells. (pharmtech.com)
  • This achievement was made possible by combining a perovskite solar cell with a textured silicon solar cell. (epfl.ch)
  • The current treatment for incomplete hematopoietic recovery includes administration of factors stimulating white and red blood cell growth, such as granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin. (drugdiscoverynews.com)
  • PLX-R18 cells, derived from mesenchymal-like cells collected from donated placentas, are designed to release a combination of therapeutic proteins to jumpstart the regeneration of a poorly functioning hematopoietic system. (drugdiscoverynews.com)
  • Immunofluorescence and immunohistochemical staining were used to detect the expression of P-gp in DLBCL cells and tissues. (greenmedinfo.com)
  • Autophagy as a self-protective mechanism of cells has been widely studied and has particular physiological effects in different tissues or cells. (hindawi.com)
  • Under the right conditions, such as certain gene activation or lowered immune system, cancer cells can migrate or ' metastasise ' and invade other tissues, which spreads the cancer. (imperial.ac.uk)
  • Dr Hernández and colleagues from the University of Tampere , Finland, studied talin's response to movement in fibroblasts - cells that help to heal wounds and repair damaged tissues. (imperial.ac.uk)
  • This correlated with increased muscle strength and decreased muscle degeneration, according to a Children's-led study published online Aug. 27, 2018, in Molecular Therapy . (childrensnational.org)
  • The study of biomimicry has already resulted in generations of aerodynamic cars designed to look like water drops and solar cells designed to mimic the structure of honeycomb. (inhabitat.com)
  • Perovskite solar cells are cheaper than silicon. (energycentral.com)
  • A little bit of excessive weather disables perovskite solar cells. (energycentral.com)
  • Scientists at Imperial College London solved this problem by injecting ferrocenes into perovskite solar cells. (energycentral.com)
  • The perovskite solar cells should cost less than alternatives. (energycentral.com)
  • Developing stronger, less costly solar cells is a step in that direction. (energycentral.com)
  • Embracing Perovskite solar cells enhanced with ferrocenes may help lower them, but a lot of work remains for that possibility to become a reality. (energycentral.com)
  • Efficient and stable organic solar cells via full coating are highly desirable. (nature.com)
  • Scalable, ambient atmosphere roll-to-roll manufacture of encapsulated large area, flexible organic tandem solar cell modules. (nature.com)
  • ITO-free and fully solution-processed semitransparent organic solar cells with high Fill factors. (nature.com)
  • Overcoming the scaling lag for polymer solar cells. (nature.com)
  • According to Mitsubishi, because of the lack of silicon supply, the company has researched ways to make silicon wafers for solar panels thinner and more efficient, while increasing electrical output. (solarindustrymag.com)
  • Schematic of the quantum dot sensitized solar cell (QDSSC) architecture (CISeS QDs are red triangles, the contacts are omitted). (phys.org)
  • This device design avoids QD-to-QD carrier transport completely (limits other QD solar cells), and benefits from more complete light absorption and a modular design. (phys.org)
  • For the first time, we have certified the performance of a quantum dot sensitized solar cell at greater than 5 percent, which is among the highest reported for any quantum dot solar cell," said Hunter McDaniel, a Los Alamos postdoctoral researcher and the lead author on a paper appearing in Nature Communications this week. (phys.org)
  • The reported solar cells are based on a new generation of nontoxic quantum dots (not containing either lead or cadmium as do most quantum dots used in solar cells). (phys.org)
  • The paper, "An integrated approach to realizing high-performance liquid-junction quantum dot sensitized solar cells" is scheduled for online publication in Nature Communications on Dec. 10, 2013. (phys.org)
  • Solar cells made of silicon are used widely but have limited power-conversion yields. (epfl.ch)
  • However, these limitations can be overcome by combining silicon with a complementary solar cell that absorbs the blue-green part of the solar spectrum and employs it more efficiently, forming what's called a "tandem. (epfl.ch)
  • A big challenge will be developing solar cells that can remain stable on our rooftops for more than 25 years. (epfl.ch)
  • Despite their huge potential, the way perovskite solar cells respond to external stimuli - such as heat or moisture - has a considerable impact on their stability. (epfl.ch)
  • Perovskite solar cells (PSCs) can be made with low-cost materials, are highly efficient, can surpass traditional silicon solar cells, and have the potential to revolutionize renewable energy. (epfl.ch)
  • Unveiling facet-dependent degradation and facet engineering for stable perovskite solar cells. (epfl.ch)
  • In this study, we investigated the role of autophagy in glibenclamide-induced insulin secretion in pancreatic β cells. (hindawi.com)
  • Thus, SUs can close the K ATP channel in pancreatic β cells, followed by membrane depolarization and open the voltage-dependent Ca 2+ channels (VDCCs) to increase intracellular calcium (Ca 2+ ), resulting in insulin secretion and decreasing blood glucose [ 4 - 6 ]. (hindawi.com)
  • Also, vitamin D reduced the incidence of T1DM, enhanced insulin secretion, and relieved pancreatic inflammation in STZ-treated mice via enhancing autophagy in pancreatic β cells [ 10 ]. (hindawi.com)
  • To determine alveolar and airways nitric oxide (NO) levels in children with sickle cell disease (SCD). (nih.gov)
  • The healthcare system can promote tailored strategies to reduce barriers and increase TCD screening and hydroxyurea use among children with sickle cell anemia. (cdc.gov)
  • In a head-to-head trial between the conventional glucocorticoid, prednisolone, and a modified glucocorticoid, vamorolone, in experimental models of LGMD2B, vamorolone improved dysferlin-deficient muscle cell membrane stability and repair. (childrensnational.org)
  • Now, scientists at EPFL and Sungkyunkwan University in South Korea have found a way to improve the stability of PSCs. (epfl.ch)
  • by identifying the most stable facets and finding ways to encourage their growth, it may be possible to improve the overall stability of PSCs and accelerate their entry into the market as a reliable and cost-effective source of renewable energy. (epfl.ch)
  • The Corning X-SERIES Cell Separation Platform is now available to simplify your cancer cell therapy workflow by offering a series of systems and technologies that can automate many of the necessary steps involved in cell processing. (corning.com)
  • Solutions for manufacturing cell therapy products must be designed for safety, process flexibility, and scale-up from research through commercial manufacturing. (labmanager.com)
  • Download this resource guide to learn how a closed cell-processing system for cell therapy manufacturing can seamlessly scale with your process from research through commercial manufacturing. (labmanager.com)
  • The multipurpose Gibco™ Cell Therapy Systems (CTS™) Rotea™ Counterflow Centrifugation System offers unparalleled flexibility. (labmanager.com)
  • The CTS Rotea Counterflow Centrifugation System is a highly versatile tool that is suitable for cell separation, as well as buffer exchange and cell concentration between cell therapy processing steps. (labmanager.com)
  • Ultimately, this serendipitous finding could enhance the quality of transplant products used in treatments like ex vivo gene therapy, improving patient outcomes . (phys.org)
  • Tseng believes cell therapy would be "much safer and much less invasive. (scitechdaily.com)
  • BUSINESS WIRE )--Positive results from the pivotal TROPION-Lung01 Phase III trial showed that datopotamab deruxtecan (Dato-DXd) demonstrated a statistically significant improvement for the primary endpoint of progression-free survival (PFS) compared to docetaxel, the current standard of care, in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) treated with at least one prior line of therapy. (businesswire.com)
  • Human brown fat progenitor cells express the calorie-burning, UCP1 proteins (green) as the cell differentiates. (scitechdaily.com)
  • We could take fat samples from patients undergoing liposuction and we could purify this specific population of progenitor cells," keeping only those that would eventually make highly active brown fat cells, "and let them differentiate into brown cells, and then get them back into the individual," Tseng said. (scitechdaily.com)
  • For example, cells made from iPSCs for a bone marrow transplant would be potentially dangerous if they contained a TET2 gene mutation linked to blood cancer, which surfaced during the study. (sciencedaily.com)
  • Professor Schneider, British Heart Foundation Professor at Imperial College London, said "Recent clinical trials using stem cells to treat heart damage have been successful in terms of safety but unfortunately the bone marrow stem cells used tend to give only a small improvement in how well the heart is pumping. (scienceblog.com)
  • We really want to use stem cells from the patients themselves that we know can give rise to beating heart cells and these are not found in bone marrow. (scienceblog.com)
  • Around 1000 patients have been treated in approximately 20 trials worldwide, mostly using bone marrow stem cells or derivatives of bone marrow cells to repair damage caused by heart attack. (scienceblog.com)
  • White blood cells are made in your bone marrow. (medlineplus.gov)
  • Herein, we showed that glibenclamide promoted insulin release and further activated autophagy through the adenosine 5′-monophosphate (AMP) activated protein kinase (AMPK) pathway in MIN-6 cells. (hindawi.com)
  • In normal ovaries, the unleashed PI3K targets a protein called Foxo3, which is then removed from the nucleus of follicle cells. (nationalgeographic.com)
  • and they don't yet have any of the full characteristics of heart muscle or blood vessel cells such as producing cardiac myosin - an important protein in heart muscle cells. (scienceblog.com)
  • WASHINGTON -Healthy muscle cells rely on the protein dysferlin to properly repair the sarcolemmal membrane, a thin specialized membrane that serves a vital role in ensuring that muscle fibers are strong enough and have the necessary resources to contract. (childrensnational.org)
  • The talin protein attaches to the cell membrane and creates a bridge between the outside and inside of the cell. (imperial.ac.uk)
  • Tezacaftor helps the CFTR protein onto the cell surface and ivacaftor then helps the CFTR ion channel to remain open for longer periods. (outsourcing-pharma.com)
  • Unlike energy-storing white, or "bad," fat cells, "good" brown fat cells make a protein called UCP1 that converts energy stored in glucose and fatty acids into heat to keep the body warm. (scitechdaily.com)
  • Some, Tseng said, act like on/off switches: When the gene is on, a brown fat cell can make the energy-burning protein, and when it is turned off, it doesn't. (scitechdaily.com)
  • In the body, these toxins inhibit protein synthesis leading to cell death. (cdc.gov)
  • This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
  • Sickle cell anemia, which primarily affects Black people, can shorten life expectancy by more than 20 years. (cdc.gov)
  • Only 2 in 5 children 2-9 years used recommended medication that can prevent sickle cell anemia complications in 2019. (cdc.gov)
  • Sickle cell anemia is the most severe form of sickle cell disease , a group of inherited red blood cell disorders causing unusually shaped, hard, and sticky red blood cells. (cdc.gov)
  • Sickle cell anemia, which primarily affects Black or African American people, is associated with a shorter life span and life-threatening complications that can affect all parts of the body. (cdc.gov)
  • Sickle cell anemia is a common cause of childhood stroke . (cdc.gov)
  • There are screenings and treatments available to ease children's suffering from sickle cell anemia. (cdc.gov)
  • Managing sickle cell anemia in children is complex. (cdc.gov)
  • Everyone can help improve care for people with sickle cell anemia by taking steps to address racism and prejudice. (cdc.gov)
  • Glibenclamide is known to promote insulin secretion by targeting β cells. (hindawi.com)
  • Previous studies have shown that glibenclamide can improve insulin secretion at low-normal glucose, which may increase the risk of hypoglycemia when attempting to maintain tight glucose control [ 8 ]. (hindawi.com)
  • β cells are the targets of glibenclamide and the only highly differentiated insulin-secreting cell in the human body, which secrete a certain amount of insulin to maintain glucose homeostasis [ 9 ]. (hindawi.com)
  • In insulin-producing β cells, excess autophagy degrades insulin granules, resulting in decreased insulin contents and systemic glucose intolerance, whereas in insulin-responsive cells, activating autophagy decreases endoplasmic reticulum (ER) stress and improves insulin sensitivity [ 17 , 18 ]. (hindawi.com)
  • This involves removing parts of the pancreas (islet cells) after the pancreas has been removed and inserting them into the liver to restart insulin production. (nice.org.uk)
  • Increased red blood cell counts and hemoglobin, hematocrit, and MCH were associated with increased fasting insulin. (lu.se)
  • The decrease in HbA1c associated with the appearance of IA-2A may be a consequence of aggressive autoimmune destruction of beta-cells leading to insulin leakage into the bloodstream. (lu.se)
  • For the study, the UCI team used a novel technique they created to entice human embryonic stem cells to differentiate into early-stage oligodendrocyte cells. (sci-info-pages.com)
  • Accurate fluid pressure in the fetal lung is critical for its development, especially at the beginning of the saccular stage when alveolar epithelial type 1 (AT1) and type 2 (AT2) cells differentiate from the epithelial progenitors. (lu.se)
  • I will discuss recent work from the lab where we uncover the mechanisms of STm targeting stem (stem-like) cells within tumours as well as the mechanism behind T cell suppression in BCT and how we can reverse this. (york.ac.uk)
  • His thesis, 'Computational modelling in systems biology: from rewriting cell fates to detecting tumours', looks at the fate of cells and how machine learning could enable surgeons to remove tumour cells with greater precision. (lu.se)
  • Professor Schneider continued: "Using heart-derived stem cells to treat heart attack and cardiomyopathy has some advantages over embryonic and induced pluripotent cells as they are potentially safer. (scienceblog.com)
  • These fuel cells can convert carbon dioxide into useful fuels using renewable electricity, potentially revolutionizing sustainable energy systems. (nanowerk.com)
  • This could potentially allow the brown fat cells to remove the high numbers of circulating glucose associated with type 2 diabetes and circulating fatty acids and triglycerides that are the hallmark of metabolic syndrome. (scitechdaily.com)
  • Among the conditions HSCT can treat are: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, myeloproliferative disorders, myelodysplastic syndromes, multiple myeloma, non-Hodgkin lymphoma, Hodgkin disease, aplastic anemia and pure red-cell aplasia-but this list is not exhaustive. (drugdiscoverynews.com)
  • Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
  • The list of diseases for which HSCT is being used is rapidly increasing, and currently numbers more than 70. (medscape.com)
  • The best proven approaches to creating new beating heart cells are using embryonic stem cells, induced pluripotent cells and heart-derived stem cells. (scienceblog.com)
  • A treatment derived from human embryonic stem cells improves mobility in rats with spinal cord injuries, providing the first physical evidence that the therapeutic use of these cells can help restore motor skills lost from acute spinal cord tissue damage. (sci-info-pages.com)
  • Keirstead and his colleagues are currently working on other approaches using human embryonic stem cells to treat chronic injuries and other disorders of the central nervous system. (sci-info-pages.com)
  • In this study we show that contactin coimmunoprecipitates with Na v 1.3 from postnatal day 0 rat brain where this channel is abundant, and from human embryonic kidney (HEK) 293 cells stably transfected with Na v 1.3 (HEK-Na v 1.3). (jneurosci.org)
  • The expression of contactin and Na v 1.3 in the HEK-Na v 1.3 stable cell line significantly increases the current density. (jneurosci.org)
  • Nonetheless, results from both cell lines suggest that the Omicron variant is more stable than the ancestral strain. (cdc.gov)
  • The increase in villus length expands the surface area of the gut and increases nutrient absorption and adiposity in mice that are fed a high-fat diet. (nature.com)
  • They first developed the method in mice and although the identifying markers are quite different in human cells, they have been able to successfully map their knowledge from mice onto humans. (scienceblog.com)
  • This study isn't the first to make mice live longer, although it does appear to be the first time the effect was achieved by targeting senescent cells. (technologyreview.com)
  • What wasn't known until today's result was whether eliminating senescent cells would also delay aging in normal mice. (technologyreview.com)
  • When the mice were 12 months old, equivalent to around 45 in human years, they were injected with a drug that cleared away the marked cells. (technologyreview.com)
  • Van Deursen says the treated mice had an improved "health span": they remained healthy for longer and seemed to develop cancer more slowly. (technologyreview.com)
  • In older HIV-positive people with or at risk of cardiovascular disease, 24 weeks of low-dose methotrexate (LDMTX) reduced CD8-cell numbers and activation but did not quell other markers of inflammation or improve endothelial function [1]. (natap.org)
  • They hypothesized (1) that LDMTX would cause no more than a 15% increase in probability of "safety events" (including drops in CD4 count and virologic failure) compared with the background rate, and (2) that reducing inflammation would improve endothelial function assessed by flow-mediated vasodilation of the brachial artery. (natap.org)
  • To study the migration of microglia across the BBB, we developed an in vitro co-culture system of mouse brain endothelial cells (MBECs) and Ra2 microglia using Transwell inserts. (portlandpress.com)
  • The addition of microglia or ATP led to the disruption of the MBEC monolayer and significantly decreased barrier function as measured by trans-endothelial electrical resistance (TEER) and electric cell-substrate impedance sensing (ECIS). (portlandpress.com)
  • In conclusion, we offer evidence that microglia migration across the brain endothelial cell monolayer is increased in the presence of ATP in a manner that involves MMP secretion. (portlandpress.com)
  • Melatonin significantly enhanced the epirubicin-induced cell proliferation suppression, epirubicin-induced apoptosis, and reduced the IC50 value of epirubicin. (greenmedinfo.com)
  • Levels of CD8 cells, an inflammation indicator, fell significantly more with LDMTX than with placebo at weeks 8, 12, and 24 (-103 versus -2 cells, P = 0.001). (natap.org)
  • Compared with people taking placebo, those taking LDMTX had significantly decreased CD8-cell activation (CD8+ CD38+ HLA-DR+) at weeks 4, 12, and 24 (all P (natap.org)
  • Using nanoindentation, it is observed that the exposed cells have significantly higher stiffness when compared to controls, especially at the nuclear region, and significant increases in surface area. (cdc.gov)
  • Epirubicin is a first-line chemotherapeutic drug for the clinical treatment of diffuse large B cell lymphoma (DLBCL), but the overexpression of multidrug resistance (MDR) transporter proteins, especially P-glycoprotein (P-gp), renders epirubicin ineffective. (greenmedinfo.com)
  • Autophagy is a self-protective pathway of cell catabolism that allows cells to degrade misfolded proteins or damaged organelles, providing energy for cells and maintaining their homeostasis [ 10 , 11 ]. (hindawi.com)
  • Both proteins control whether or not cancer cells spread to other parts of the body, but the exact mechanisms have remained unclear. (imperial.ac.uk)
  • Purified GST fusion proteins of the N and C termini of Na v 1.3 pull down contactin from lysates of transfected HEK 293 cells. (jneurosci.org)
  • Further, melatonin synergized with epirubicin to promote the activation of the mitochondria-mediated apoptosis pathway and increased the accumulation of epirubicin in DLBCL cells by inhibiting the expression and function of P-gp. (greenmedinfo.com)
  • Using iPSCs for treatment has already been initiated in Japan in a woman with age-related macular degeneration," said paper co-author and STSI Director Eric Topol, M.D. "Accordingly, it's vital that we fully understand the effects of aging on these cells being cultivated to treat patients in the future. (sciencedaily.com)
  • When we proposed this study, we weren't sure whether it would even be possible to grow iPSCs from the blood of the participants in the Wellderly Study, since others have reported difficulty in making these stem cells from aged patients," Baldwin said. (sciencedaily.com)
  • Also, the genes that identify these weakly adherent cells make patients' tumors five times more likely to reoccur within five years. (news-medical.net)
  • Patients with few of these aggressive cells lying dormant in their surrounding tissue may be less likely to see a tumor reoccur 5, 10, or 20 years later. (news-medical.net)
  • Patients with severe Covid-19 infections were found to have raised levels of platelet producing cells, which help the blood to clot. (nursinginpractice.com)
  • This matches experience in the clinic as patients with LGMD2B experienced increased muscle weakness after being prescribed conventional glucocorticoids, such as prednisolone. (childrensnational.org)
  • Three different doses of vamorolone were tested on cells derived from patients with LGMD2B with higher cell membrane repair efficacy seen with rising treatment dose. (childrensnational.org)
  • However, maintaining the fitness of these cells outside of the body poses a challenge, and any loss of fitness introduces the risk that the cells will not properly restore the blood and immune cell system in patients. (phys.org)
  • Pluristem Therapeutics, based in Haifa, Israel, is currently recruiting patients in the United States and Israel for its Phase 1 trial of PLX-R18 cells in this unmet need. (drugdiscoverynews.com)
  • Symkevi combines active agents tezacaftor with ivacaftor, also known by the brand name Kalydeco - when combined they help improve the performance of the CFTR channel in CF patients. (outsourcing-pharma.com)
  • For patients with advanced non-small cell lung cancer, current standard of care second-line docetaxel is associated with limited benefit and substantial toxicity. (businesswire.com)
  • The improvement in progression-free survival observed with datopotamab deruxtecan, particularly in patients with non-squamous tumors, and the improved tolerability of this antibody drug conjugate compared to docetaxel, represent a meaningful advance for patients with lung cancer. (businesswire.com)
  • The TROPION-Lung01 results demonstrate for the first time that an antibody drug conjugate can delay disease progression or death for longer than conventional chemotherapy in patients with advanced non-small cell lung cancer. (businesswire.com)
  • The benefit seen in patients with non-squamous tumors is particularly impressive and, coupled with the data from TROPION-Lung05, provides promising evidence that datopotamab deruxtecan may play an important role in treating patients with non-small cell lung cancer who currently have limited effective options following initial treatment. (businesswire.com)
  • Nous avons génotypé les deux polymorphismes mononucléotidiques du gène ADIPOQ chez 140 patients atteints de DNID sans lien de parenté et 66 témoins non diabétiques en recourant à l'analyse du polymorphisme de longueur des fragments de restriction par réaction en chaîne de polymérase. (who.int)
  • Conn Hastings received a PhD from the Royal College of Surgeons in Ireland for his work in drug delivery, investigating the potential of injectable hydrogels to deliver cells, drugs and nanoparticles in the treatment of cancer and cardiovascular diseases. (medgadget.com)
  • Their work addresses a longstanding problem in the field of cancer research: it has been difficult to find biological markers to universally identify and select the most aggressive cells in tumors. (news-medical.net)
  • Cancer cells are placed in the chamber and after they adhere, a fluid is pushed through to detach cells. (news-medical.net)
  • If our mouse model shows that these cells indeed reduce cancer-free survival times, it will pave the way for substantial prognostic studies in humans with these types of solid tumors,' said first author Pranjali Beri, a bioengineering Ph.D. student in Engler's lab. (news-medical.net)
  • None of the cells ever developed into a tumour, which is a real concern since one of PTEN's role is to keep cancer at bay. (nationalgeographic.com)
  • These wrinkly rodents, already known for being resistant to cancer, produce egg cells their whole lives-an extremely rare trait in mammals. (nationalgeographic.com)
  • Because removing senescent cells could treat a range of ailments, Unity will attempt to raise and spend large sums of money to advance drugs into studies, says Robert Nelsen, the managing director of Arch, who has played a leading role in some recent high-profile startups including Juno Therapeutics as well as Grail, a $100 million effort to develop cancer blood tests announced this year. (technologyreview.com)
  • Cells' inner structures, known as cytoskeletons, produce the forces that lead to cell migration in cancer cells. (imperial.ac.uk)
  • This increases the risk of cancer and puts the dangers of even moderate drinking into perspective. (mercola.com)
  • Datopotamab deruxtecan is central to the future we envision where antibody drug conjugates improve upon and ultimately displace entrenched standards of care, like chemotherapy, in multiple cancer types. (businesswire.com)
  • The switch to aerobic glycolysis , known as the Warburg effect, in cancer cells leads to an increased production of methylglyoxal (MGO), a potent glycation agent with pro-tumorigenic characteristics. (bvsalud.org)
  • The analysis showed that multiple types of immune cells are involved in the body's response to the virus. (nursinginpractice.com)
  • The B cells produce antibodies against Covid-19 and are found in mucus membranes such as the nasal passage, which may be one of the body's first line of defence against the virus. (nursinginpractice.com)
  • Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway. (greenmedinfo.com)
  • Epirubicin was subsequently discovered to upregulate the expression of P-gp by activating the NF-κB pathway in the DLBCL cells. (greenmedinfo.com)
  • Our results demonstrated that melatonin inactivates the NF-κB pathway and downregulates the expression of P-gp, ultimately sensitizing DLBCL cells to the epirubicin that suppresses their growth. (greenmedinfo.com)
  • Of the 336 different mutations that were identified in the iPSCs generated for the study, 24 were in genes that could impair cell function or trigger tumor growth if they malfunctioned. (sciencedaily.com)
  • This study may provide a much-needed physical marker that identifies highly metastatic cells within a heterogeneous tumor cell population. (news-medical.net)
  • Beri also noted that nearly any solid tumor should exhibit this physical marker, and the team has so far tested cells from breast, prostate, and lung tumors. (news-medical.net)
  • By further understanding how adipose cells become thermogenically active, meaning they use energy to produce heat and thus burn calories, we may discover novel therapeutics for the treatment of obesity and metabolic disease," said Chad Cowan, an HSCI principal faculty member who, among other things, also studies the therapeutic potential of brown fat cells. (scitechdaily.com)
  • Voltage-gated sodium channels mediate a rapid and transient increase in Na + permeability in response to membrane depolarization, thereby contributing to the generation and conduction of action potentials. (jneurosci.org)
  • This flexible multi-system platform provides a streamlined solution with speed and performance gains in purifying mononuclear cells, washing contaminants from cell fractions, selecting specific cell populations and concentrating cellular suspensions. (corning.com)
  • The Dallas Cowboys are the latest National Football League franchise to add new antennas to their stadium in an effort to improve cellular connectivity and data speeds. (nbcchicago.com)
  • This triggered an increase in paracellular permeability via cellular redistribution of claudin 3 (CLDN3) from TJs into cell nuclei followed by disruption of epithelial integrity and formation of epithelial lesions. (springer.com)
  • While the incidence of children suffering from autoimmune type 1 diabetes (T1D) is increasing in Sweden and worldwide, the underlying etiology and cellular mechanisms behind this remain unknown. (lu.se)
  • This study aims to identify peripheral blood biomarkers to predict and explain cellular autoimmune processes leading to beta-cell loss before and after seroconversion. (lu.se)
  • 2020) Cell adhesiveness serves as a biophysical marker for metastatic potential. (news-medical.net)
  • The predisposition of the high-risk HLA DR-DQ genotype and as yet unknown environmental triggers lead to autoimmunity and the onset of T1D, which is preceded by islet beta-cell autoantibodies acting as markers for ongoing autoimmunity. (lu.se)
  • Children participating in the Swedish TEDDY cohort with or without islet beta-cell autoantibodies were studied. (lu.se)
  • Reductions in neutrophil levels, red blood cells, and red blood cell parameters and increased levels of HbA1c are all associated with multiple autoantibodies, reflecting a prominent islet autoimmune burden. (lu.se)
  • In summary, we demonstrate a role of motile cilia in TGF-β1 sensing and showed that TGF-β1 disturbs TJ permeability of conductive airway epithelia by redistributing CLDN3 from TJs into cell nuclei. (springer.com)
  • The increase in complexity of N-linked oligosaccharides is considered to be brought about by the increased levels of intracellular uridine diphosphate-GlcNAc/GalNAc. (nih.gov)
  • Studies have shown that autophagy plays an important role in many organs, especially metabolic organs, which not only maintain the basic homeostasis of cells but also regulate cells' function [ 14 ]. (hindawi.com)
  • One trial is testing whether MSCs with or without peripheral blood stem cells could treat poor graft function and delayed platelet engraftment. (drugdiscoverynews.com)
  • In another trial, this group is evaluating whether peripheral blood stem cells combined with MSCs can treat poor graft function. (drugdiscoverynews.com)
  • Peripheral blood biomarkers of cell-specific autoimmunity. (lu.se)
  • Controlling the genes might allow scientists to make mediocre brown fat cells work better. (scitechdaily.com)
  • The body has about 10 trillion cells of 200 different types, and it is the switching on and off of genes in the cells' DNA that determines what kind of cell it is. (lu.se)
  • Incomplete engraftment (poor graft function) requires the patient to undergo more transfusions of red cells or platelets. (drugdiscoverynews.com)
  • There are complications of serial transfusions of either of these cell types, and a patient needs intense prophylactic treatments to protect from infections if his or her white counts are low. (drugdiscoverynews.com)
  • Separate, wash, and reduce the volume of cells or cell cultures to a customized volume for tailored downstream applications. (corning.com)
  • Enzymatic removal of contactin from the cell surface of cotransfected cells does not reduce the elevated levels of the Na v 1.3 current. (jneurosci.org)
  • While plain graphene sheets can reduce fuel crossover, they also inhibit proton conductivity, which is critical for fuel cell performance. (nanowerk.com)
  • By providing a simple method to balance proton conduction versus fuel crossover, this advance removes a major roadblock for fuel cell systems that can utilize renewable resources and reduce dependence on fossil fuels. (nanowerk.com)
  • When active, brown fat cells can also use energy stored by white fat cells, and as a result reduce the size of nearby white fat cells. (scitechdaily.com)
  • Any time a cell divides, there is a risk of a mutation occurring. (sciencedaily.com)
  • Our study highlights that increased risk of mutations in iPSCs made from older donors of source cells. (sciencedaily.com)
  • A counterflow centrifugation system designed for closed manufacturing reduces the risk of errors associated with manual cell processing to create a safer product. (labmanager.com)
  • Transcranial doppler (TCD) ultrasound screening, which identifies children with increased risk for stroke. (cdc.gov)
  • All risk factors were associated with increased dementia risk in the total cohort. (medscape.com)
  • This makes it harder for your body to make new white blood cells that can fight infection and increases your infection risk. (medlineplus.gov)
  • There is also a risk that the body will reject cells transplanted from another person. (lu.se)
  • Studies in children at increased risk for type 1 diabetes. (lu.se)
  • Increased HbA1c was associated with an increased risk of T1D regardless of the number and type of autoantibodies. (lu.se)
  • It cannot be excluded that abacavir might be associated with an increased risk of heart attack. (who.int)
  • Tell your health care provider if you have heart problems, if you smoke, or if you have other illnesses that may increase your risk of heart disease, such as high blood pressure or diabetes. (who.int)
  • We initially embarked on this project to better understand the role of these vesicles, assuming-wrongly, as it turns out-that blocking their function would have detrimental effects on the cells," said first author Stephanie Hurwitz, MD, Ph.D., a research fellow in the Kurre Lab at CHOP and Hematopathologist at the University of Pennsylvania. (phys.org)
  • One process that we now learn contributes to cell equilibrium is the secretion of EVs, which are important for delivering messages from cell to cell and maintaining proper cell function. (phys.org)
  • The reduction in different complete blood counts with increasing numbers of beta-cell autoantibodies may suggest an unknown effect of impaired beta-cell function on hematopoiesis. (lu.se)
  • The human body is arguably one of the finest machines ever created by nature, and now a team from Norway's Academy of Science and Letters in Oslo are looking to it for inspiration as they design the next generation of hydrogen fuel cells. (inhabitat.com)
  • It's also notable that of these three cell types, it's only heart-derived cells that are in current human clinical trials for this sort of treatment. (scienceblog.com)
  • Dr Sarah Teichmann, senior author and co-chair of the Human Cell Atlas Organising Committee, added: 'This information can be used to better understand why different people react to coronavirus in different ways. (nursinginpractice.com)
  • They underscore the great potential that stem cells have for treating human disease and injury," Keirstead said. (sci-info-pages.com)
  • Herein we elaborated effects of TGF-β1 on TJs of primary human bronchial epithelial cells. (springer.com)
  • In this study, we investigated the impact of MGO on the LN229 and U251 ( WHO grade IV, GBM) cell lines and the U343 ( WHO grade III) glioma cell line , along with primary human astrocytes (hA). (bvsalud.org)
  • While human embryos contain stem cells that can develop into any type of cell, there are ethical dilemmas about using cells from embryos for medical purposes. (lu.se)
  • 1987. The effect of electrically generated silver ions on human cells. (cdc.gov)
  • Such broad applications of CNTs have led to an increased production level and thus increased concerns regarding human and environmental exposure. (cdc.gov)
  • The biggest challenge is to make an ideal product for transplant, which would be either a mixture of heart muscle- and blood vessel-forming cells or a pure population of some sort of precursor that could give rise to both muscle and blood vessel cells. (scienceblog.com)
  • But when this process breaks down and garbage in the form of necrotic cells starts building up in the walls of blood vessels, it's not a good thing. (stanford.edu)
  • The study, published in the journal Blood , showed that targeting components in the cells called extracellular vesicles (EVs) relieves the stress on cells when outside of the body, improving their performance when they are transplanted back inside. (phys.org)
  • These cells clump together, blocking blood flow carrying oxygen through the body. (cdc.gov)
  • Your health care provider will check your white blood cell count during your treatment. (medlineplus.gov)
  • When levels of certain white blood cells drop too low, it is called neutropenia . (medlineplus.gov)
  • A reduction in neutrophil counts primarily in boys and children with the HLA-DR3-DQ2/DR4-DQ8 genotype, and a reduction of red blood cell counts, hemoglobin, and hematocrit primarily in girls and in children with HLA-DR3-DQ2/DR4-DQ8 were inversely associated with autoimmunity and the number of beta-cell autoantibodies. (lu.se)
  • A reduction in red blood cell indices (MCH and MCV) was associated with increased HbA1c, by increased number of beta-cell autoantibodies. (lu.se)
  • Reduction in red blood cell count, hemoglobin, and hematocrit levels were associated with increased fasting blood glucose. (lu.se)
  • It is believed that TGF-β1 signalling is involved in controlling epithelial cell proliferation, to drive epithelial-mesenchymal transition (EMT) and it plays a major role in lung fibrosis and emphysema. (springer.com)
  • Lung epithelial cells form a barrier that lines airway and alveolar surfaces and constitute an air-liquid interface. (springer.com)
  • Our findings show that balanced ROCK-Yap/Taz signaling is essential to regulate AT1 differentiation in response to mechanical stretching of the fetal lung, which might be helpful in improving lung development and regeneration. (lu.se)
  • EU-funded scientists working on the project MCFC-CONTEX are optimising exploitation of molten-carbonate fuel cells (MCFCs) for this purpose. (europa.eu)
  • Now, a team of Chinese, Japanese and American scientists, led by Jing Li from Stanford University, have found a way to activate these dormant cells at will. (nationalgeographic.com)
  • The research team, made up of scientists at Harvard University and at Harvard-affiliated Joslin Diabetes Center and led by HSCI principal faculty member Yu-Hua Tseng, determined that the amount of energy burned varies from person to person and from cell to cell. (scitechdaily.com)
  • Biomedical engineers at Johns Hopkins performed a study on heart cell cultures and found that the cause of these dangerous arrhythmias may be a result of multiarm spirals. (mddionline.com)
  • When the team tested the molds, they found that the cells matured more quickly and showed enhanced functionality, compared with traditional 2D culture. (medgadget.com)
  • In people with severe Covid-19 symptoms, the immune cells found in asymptomatic people were missing. (nursinginpractice.com)
  • What he found was that if cells were blocked from entering a state of senescence, the early symptoms of old age were mostly avoided. (technologyreview.com)
  • This placebo-controlled AIDS Clinical Trials Group (ACTG) study found high adverse event rates in both study arms, although less than 15% increase in probability of key safety events. (natap.org)
  • This kind of system can already be found in all commercially available crystalline silicon cells. (epfl.ch)
  • Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
  • Although the total number of NPL sites evaluated for this substance is not known, the possibility exists that the number of sites at which vanadium is found may increase in the future as more sites are evaluated. (cdc.gov)
  • The ability of fructose to promote cell survival through an allosteric metabolite thus provides additional insights into the excess adiposity generated by a Western diet, and a compelling explanation for the promotion of tumour growth by high-fructose corn syrup. (nature.com)
  • Emil Andersson uses computational models to investigate cell reprogramming and how tumour cells can be better recognised using machine learning. (lu.se)
  • And what if machine learning allowed surgeons to precisely remove tumour cells on the operating table? (lu.se)
  • In the presence of 15 mM exogenously added NH4Cl, a significant and reproducible increase in tri- and tetraantennary oligosaccharides (45% of total) was detected in the secretion product. (nih.gov)
  • How troublesome these mutations could be depends on how well the stem cells are screened to filter out the defects and how they are used therapeutically, Torkamani said. (sciencedaily.com)
  • This sulfanilic-functionalized holey graphene allowed proton conductivity comparable to standard fuel cell membranes while reducing methanol and formic acid crossover by around 80% and 60%, respectively. (nanowerk.com)
  • Rapidly isolate mononuclear cells from various sources with this semi-automated, functionally closed system. (corning.com)
  • The effect of different ammonium concentrations and glucosamine on baby hamster kidney (BHK)-21 cell cultures grown in continuously perfused double membrane bioreactors was investigated with respect to the final carbohydrate structures of a secretory recombinant glycoprotein. (nih.gov)
  • Professor Muzlifah Haniffa, a senior author of the study and professor of dermatology and immunology from the University of Newcastle, said: 'The immune system is made up of lots of different groups of cells, similar to the way an orchestra is made up of different groups of instruments, and in order to understand the coordinated immune response, you have to look at these immune cells together. (nursinginpractice.com)
  • The mechanical properties of substrates play an important role in the cell behavior because the mechanical cues that cells sense in the actual (heart) environment is unique," said Abadi. (medgadget.com)
  • Like a skeleton controlled by outside mechanical forces, cells contract and move in response to outside forces. (imperial.ac.uk)
  • Increased mechanical tension showed to improve alveolar maturation and differentiation toward AT1. (lu.se)