Cell immunization secondary. Medical search. Frequent questions

however, the vaccine does elicit both serum (2,9) and intestinal (10) antibodies and cell-mediated immune responses (11). (cdc.gov)
However, secondary transmission of vaccine organisms has not been documented. (cdc.gov)
Title: Evaluation of the effects of age, prior exposure and previous vaccination on the B cell response to inactivated influenza vaccine in healthy adults and children. (rochester.edu)
To evaluate the relationship between first influenza A virus exposure (inferred by age), vaccine history, and baseline serum antibody and Memory B cell (MBC) specificity, and the magnitude and breadth of the subsequent B cell response to seasonal influenza vaccine in healthy adults and children. (rochester.edu)
For patients with HIV and CD4 counts ≥200 cells/mm 3 , inactivated forms of vaccines such as those for polio, influenza, typhoid, and zoster are preferred over the live vaccine options. (hivguidelines.org)
To enable global accessibility, we generated a cell line that can enable production of thousands of vaccine doses per liter of cell culture and show that DCFHP-alum maintains potency for at least 14 days at temperatures exceeding standard room temperature. (stanford.edu)
Universal immunisation is the cornerstone of preventive medicine for children, The World Health Organisation (WHO) recommends diphtheria-tetanus-pertussis (DTP) vaccine administered at 6, 10 and 14 weeks of age as part of routine immunisation. (biomedcentral.com)
Secondary outcomes include antibodies against other vaccine antigens in the primary schedule and their safety. (biomedcentral.com)
On the basis of these considerations and observations, we hypothesised that a genetically engineered viral pathogen that can be triggered transiently in an inoculation site region to (local) replicate will be a superior immunisation agent to a traditional vaccine with an efficiency approaching that of the corresponding wild type agent[11]. (digiwire.co.in)
The immune system responds to the vaccine by increasing the number of specific memory cells and antibodies for the particular disease. (3d4medical.com)
However, multiple hurdles exist for the realisation of a universal T cell vaccine. (mdpi.com)
The timely completion of the childhood immunisation schedule for children under the age of 1 year by caregivers is key to reducing the high morbidity and mortality of vaccine-preventable diseases among infantsglobally.Objective. (bvsalud.org)
Mobile phone ownership was 74.5% among rural-based respondents, and 95.8% among urbanbased.Forty-six percent of the respondents had good knowledge of immunisation, vaccine-preventable diseases and vaccination schedules,while 27.5% had poor knowledge. (bvsalud.org)

Routine vaccination at age 11 or 12 years has been recommended by the Advisory Committee on Immunization Practices (ACIP) since 2006 for females and since 2011 for males ( 1 , 2 ). (cdc.gov)
In our study using a vaccinia virus infection model, we found that T cell cross-competition is highly relevant during boost vaccination, thereby shaping the immunodominance hierarchy in the recall. (nih.gov)
For example, patients with autoimmune conditions or chronic lymphocytic leukemia treated with B cell-depleting antibodies have predictably diminished humoral responses to vaccination, whereas responses by patients on anti-TNF therapies are less affected 6 , 7 . (nature.com)
His work covers various topics, including B cell responses to viral infection and vaccination, human primary immunodeficiency, and biology of lymphocyte development and function and to elucidate etiology of immunological disorders. (stanford.edu)
This property of cells is used as the basic principle of vaccination . (schoolsonweb.com)
A Novel Approach on Immunization by Replication- Competent, Controlled Viral Pathogen: Exploring for Diseases Refractory to Effective Conventional Vaccination? (digiwire.co.in)

In the case of dengue, enhancement of virus replication by heterologous flavivirus antibodies and T-cell activation are thought to occur in some patients during a second or sequential dengue infection, resulting in hemorrhagic fever or shock ( 15 , 16 ). (cdc.gov)
Neutralizing antibodies were detected in 67% of patients with cancer after the first immunization, followed by a threefold increase in median titers after the second dose. (nature.com)
Similar patterns were observed for spike protein-specific serum antibodies and T cells, but the magnitude of each of these responses was diminished relative to the control cohort. (nature.com)
Here we show that anti-mouse 4-1BB monoclonal antibodies (mAbs) inhibit thymus-dependent antibody production by B cells. (rupress.org)
This review offers summarized information about IgY production and the use of these antibodies for passive immunization, particularly in poultry. (ac.be)
In this study, the production of antibodies was assessed against sheep red blood cells (SRBC) in the anuran Bufo arenarum after six weekly injections of sublethal doses of lead (50 mg.kg -1 , as lead acetate). (scielo.org.ar)
It was thus concluded that the changes due to the assayed doses of Pb in the levels of antibodies cannot be explained on the basis of only one single action mechanism of the metal, but as the result of a conjunction of effects over different immunocompetent cell subpopulations. (scielo.org.ar)
Once activated B cells begin to secrete proteins known as antibodies which enhance the immune system's efforts to combat infection. (3d4medical.com)
B memory cells produce many antibodies in response to very small levels of pathogen and make immunization possible. (3d4medical.com)
Next-generation vaccines that utilize T cells could potentially overcome the limitations of current influenza vaccines that rely on antibodies to provide narrow subtype-specific protection and are prone to antigenic mismatch with circulating strains. (mdpi.com)
T follicular helper (Tfh) cells are essential in the induction of high-affinity, class-switched antibodies. (bioxcell.com)

These revised recommendations of the Advisory Committee on Immunization Practices update previous recommendations (MMWR 1990;39{RR-10}:1-5). (cdc.gov)

Abstract: Disclosed are methods of reducing lung inflammation in acute respiratory distress syndrome elicited by various factors such as COVID-19 infection by reduction of neutrophil extracellular trap formation through administration of mesenchymal stem cells and/or exosomes thereof. (therapeuticsolutionsint.com)
Abstract: Various cells, stem cells, and stem cell components, includ-ing associated methods of generating and using such cells are provided. (therapeuticsolutionsint.com)

CD8+ T cell responses directed against multiple pathogen-derived epitopes are characterized by defined immunodominance hierarchy patterns. (nih.gov)
Results from the analysis showed a median overall survival (OS) of 26 months and demonstrated that responses remained durable in adults with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) with a consistent safety profile observed since the two-year analysis. (gilead.com)
In most patients with cancer, we detected spike receptor-binding domain and other S1-specific memory B cell subsets as potential predictors of anamnestic responses to additional immunizations. (nature.com)
primary outcomes were immune responses, with a secondary outcome of safety. (nature.com)
At 1 week after a third immunization, 16 participants demonstrated a median threefold increase in neutralizing antibody responses, but no improvement was observed in T cell responses. (nature.com)
Notably, organ transplant recipients mount very poor antibody responses to the first mRNA immunization relative to healthy individuals 10 , which increase somewhat after the second immunization 8 . (nature.com)
Similarly, in patients with cancer with solid or hematological malignancies, antibody responses are markedly diminished after the first immunization but improve somewhat after the second 9 . (nature.com)
Here we analyzed the innate and adaptive responses to BNT162b2 in mice, and show that immunization stimulated potent antibody and antigen-specific T cell responses, as well as strikingly enhanced innate responses after secondary immunization, which was concurrent with enhanced serum interferon (IFN)-gamma levels 1d following secondary immunization. (stanford.edu)
Analysis of knockout mice revealed that induction of antibody and T cell responses to BNT162b2 was not dependent on signaling via Toll-like receptors 2, 3, 4, 5 and 7 nor inflammasome activation, nor the necroptosis or pyroptosis cell death pathways. (stanford.edu)
T cell responses developed or increased in 20%/60%/100% of pts in Arms A/B/C. Seven of the 19 patients remain alive at a minimum 32 months from trial initiation, including three with unresectable disease. (bmj.com)
Conclusions The T cell response in this randomized phase I trial was dose-dependent with the 1 mg CEA peptide dose eliciting the most robust T cell responses. (bmj.com)
Although attenuation provides the protection needed, the ability of so-modified pathogens to induce robust inflammatory responses is almost universally compromised, which translates into suboptimal humoral and T-cell responses[3-6]. (digiwire.co.in)
Upon ICOSL binding, ICOS signaling co-stimulates T and B cell responses. (bioxcell.com)
Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells. (unil.ch)
Lymph nodes (LNs) are secondary lymphoid tissues that play a critical role in filtering the lymph and promoting adaptive immune responses. (ethz.ch)
Upon immunization, LOs support the activation of antigen-specific immune responses, thus acquiring properties of native lymphoid tissues. (ethz.ch)

This study was performed to determine the effects of human placenta mesenchymal stem cell (hPMSC) transplantation on granulosa cell apoptosis and anti-Müllerian hormone (AMH) and follicle-stimulating hormone receptor (FSHR) expression in autoimmune drug-induced premature ovarian failure (POF) mice. (biomedcentral.com)
hPMSC transplantation can significantly improve the serum levels of high gonadotropin and low estrogen of POF mice, promote follicular development, inhibit excessive follicular atresia and granulosa cell apoptosis, and improve the ovarian reserve capacity. (biomedcentral.com)
Here we demonstrate that in mice treated with FTY720 or that lack sphingosine-1-phosphate (S1P) receptor-1 (S1P 1 ) in B cells, IgG ASCs are induced and localize normally in secondary lymphoid organs but they are reduced in numbers in blood and BM. (silverchair.com)
HK5.3 treatment of mice has been reported to lead to a loss of regulatory T cells. (bioxcell.com)
Regulatory T cells (Tregs), a subset of CD4(+) T cells, dramatically accumulate with age in humans and mice and contribute to age-related immune suppression. (bioxcell.com)
Next, we analyzed the gene expression profile of Tregs, naive T cells, and memory T cells in aged mice. (bioxcell.com)

SANTA MONICA, Calif.--(BUSINESS WIRE)-- Kite, a Gilead Company (Nasdaq: GILD), today announces that the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion for Yescarta ® (axicabtagene ciloleucel) for adult patients with diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma (HGBL) that relapses within 12 months from completion of, or is refractory to, first-line chemoimmunotherapy. (gilead.com)

In adults, B-cell precursor ALL is the most common form, accounting for 75% of cases. (gilead.com)
This compendium of immunization recommendations for adults (≥18 years) with HIV was compiled by the New York State Department of Health AIDS Institute (NYSDOH AI) to assist clinical practitioners in New York State who provide primary care to adults with HIV. (hivguidelines.org)

This leakage allows a virus to move systemically while also increasing secondary bacterial infections. (financialnewsmedia.com)
Antibiotics may prevent or alleviate secondary bacterial infection. (medscape.com)
The bacterial cells expressed recombinant TSWV-N protein up to a concentration of 9.48 µg/ml. (chxa.com)

Brodsky's work straddles the interface of immunology and cell biology. (wikipedia.org)
I was working on cell biology related to immunology around the time I wrote Braun into existence. (nature.com)

A possible explanation for this phenomenon is that CD8+ T cells of different specificities compete for access to epitopes on antigen-presenting cells, and that the outcome of this so-called cross-competition reflects the number of induced T cells. (nih.gov)
The immunologic mechanism for alloimmunization to antigens found on transfused cells involves presentation of the donor antigens by donor antigen-presenting cells (APCs), i.e., monocytes, macrophages, dendritic cells, and B cells, to recipient T cells. (medscape.com)
The ligand Is expressed on antigen presenting cells including splenic B cells, dendritic cells, and macrophages. (bioxcell.com)

Afterwards, many responding cells going through a conherent cycle to produce specific immunity. (pharmacology2000.com)
The identification of lymphocytes as the main cell type responsible for both cellular and humoral immunity started in the early 1950s with the emergence of cell culture techniques. (frontiersin.org)
Objectives: Primary Objectives: To induce cellular and humoral immunity in allogeneic stem cell donors and recipients against the unique idiotype expressed by the recipient's myeloma. (drugpatentwatch.com)
To determine whether antigen-specific immunity, induced in the stem cell donor, can be passively transferred to the allogeneic SCT recipient in the setting of a non-myeloablative conditioning regimen. (drugpatentwatch.com)
2015). "ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation" Immunity 42(2): 239-251. (bioxcell.com)

To reinstate routine services, priority actions and key areas include continued provision of family planning services along with uninterrupted immunization campaigns and routine maternal and child services. (who.int)
The high mobile phone ownership level, and the willingness of caregivers of infants in this study area to receive immunisation schedule reminder messages, is encouraging, and should be optimised to improve routine immunisation uptake. (bvsalud.org)

ide-cel) as the first B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of adult patients with relapsed or refractory multiple myeloma after four or more prior lines of therapy, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 monoclonal antibody. (drugs.com)
CAR T cell therapies have shown transformational potential for the treatment of hematologic malignancies, and we, with our partners at bluebird bio, are proud to bring the first CAR T cell therapy to appropriate triple-class exposed patients with relapsed or refractory multiple myeloma, offering the chance for durable response," said Samit Hirawat, M.D., chief medical officer, Bristol Myers Squibb. (drugs.com)
TECARTUS ® (brexucabtagene autoleucel) is a CD19-directed genetically modified autologous T cell immunotherapy indicated for the treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL). (tecartushcp.com)
With these two new indications, Breyanzi now has the broadest patient eligibility of any CAR T cell therapy in relapsed or refractory LBCL. (wapakdailynews.com)

With the ban on sub-therapeutic antibiotic usage in Europe and the increasingly strictness of the European legislation on food hygiene, passive immunization by oral administration of pathogen-specific hen egg yolk antibody (IgY) may be a useful and attractive alternative. (ac.be)
IgG coats the surface of the pathogen, allowing ingestion of pathogens by immune cells like neutrophils and macrophages. (3d4medical.com)

FOXO1 regulated Tfh cell differentiation through a broad program of gene expression exemplified by its negative regulation of Bcl6. (bioxcell.com)
We found that the gene expression profile of aged CD25(lo) Tregs were more related to young CD25(lo) Tregs than to either naive or memory T cells. (bioxcell.com)

It strongly depended on the timing of viral antigen expression in infected APCs, and it was characterized by poor proliferation of T cells recognizing epitopes derived from late viral proteins. (nih.gov)
To our knowledge, this is the first demonstration of the functional importance of T cell cross-competition during a viral infection. (nih.gov)
Viral infections do so by causing damage to the cells that make up the inner wall of blood vessels, called the endothelium. (financialnewsmedia.com)
The viral particle is composed of a protein capsid that contains a positive-sense RNA molecule of about 8,500 nucleotides that is infectious and encodes a single polyprotein, which is processed in infected cells by cis - and trans -acting viral proteases ( 55 ) to yield different polypeptide precursors and the mature viral proteins ( 9 , 62 ). (asm.org)
Replication of picornaviruses occurs associated to cell endomembranes that are recruited during viral infection ( 25 ). (asm.org)
NS proteins are involved in crucial aspects of the viral cycle and pathogenesis, such as rearrangements of intracellular membranes required for endomembrane recruitment and the lysis of host cells ( 1 , 12 , 14 , 18 , 73 ). (asm.org)

Bramson[12] endorsed that full immune response can be obtained from immunisation with a disease-causing virus modified to subject replication-essential genes to the control of a non-lethal heat-activated gene switch in the presence of a drug-like compound. (digiwire.co.in)

Clathrin-mediated endocytosis is involved in the uptake of antigens from outside the cell that are eventually presented on the surface of the cell by the major histocompatibility complex class II (MHC class II). (wikipedia.org)
[ 1 ] This procedure introduces a multitude of foreign antigens and viable cells into the recipient that persist for a variable time. (medscape.com)
A recipient who is immunocompetent may mount an immune response to the donor antigens (i.e., alloimmunization), resulting in various clinical consequences, depending on the blood cells and specific antigens involved. (medscape.com)
The OptImms trial will assess whether antibody titres against pertussis and other antigens in childhood can be maintained whilst adjusting the current Expanded Programme on Immunisation (EPI) schedule to provide space for the introduction of new vaccines. (biomedcentral.com)
Due to the artificial nature of drug/chemical-T-cell epitopes, it is not clear whether thymic selection of drug/chemical-specific T cells is a common phenomenon or remains limited to few donors or simply does not exist, suggesting T-cell receptor (TCR) cross-reactivity with other antigens. (frontiersin.org)

Following a booster ~one year after the initial immunization, DCFHP-alum elicits a robust anamnestic response. (stanford.edu)

By age 20, over 40% of patients develop a malignant disease and are prone to develop secondary malignancies. (orpha.net)
HIV-related infections and malignancies escalate in frequency and severity as the absolute CD4 T cell count falls toward 200 cells/μL and below. (medscape.com)

The National Advisory Committee on Immunization (NACI) recommends immunization against pertussis. (canada.ca)
Pertussis is highly communicable with studies showing 80% secondary attack rates among susceptible household contacts. (canada.ca)
As a result of widespread immunization programs, proper nutrition and good medical care pertussis incidence has decreased in high income countries. (canada.ca)
Pertussis can be prevented by immunization. (canada.ca)
Prevention through immunization remains the best defense in the fight against pertussis. (medscape.com)

The goal of this protocol is to provide serum, peripheral blood mononuclear cells, respiratory secretions and other body fluids from healthy donors for the development of assays related to the study of influenza and to assist the laboratories in quality control activities. (rochester.edu)
On histopathology, this fibroinflammatory disease is characterized with specific findings such as lymphoplasmacytic infiltration of IgG4-positive plasma cells, obliterative phlebitis, and storiform fibrosis, in most cases accompanied by increased levels of serum IgG4 [ 10 ]. (hindawi.com)

Sickle-cell anaemia is a common genetic condition due to a haemoglobin disorder - inheritance of mutant haemoglobin genes from both parents. (who.int)
About 5% of the world's population carries genes responsible for haemoglobinopathies and each year about 300 000 infants are born with major haemoglobin disorders - in more than 200 000 cases sickle-cell anaemia in Africa. (who.int)
Although a single abnormal gene may protect against malaria, inheritance of two abnormal genes leads to sickle-cell anaemia and confers no such protection, and malaria is a major cause of ill-health and death in children with sickle-cell anaemia. (who.int)
The differentiation of Tfh cells is a multi-step process that depends upon the co-receptor ICOS and the activation of phosphoinositide-3 kinase leading to the expression of key Tfh cell genes. (bioxcell.com)
Individuals who inherit sickle-cell genes from both parents are homozygotes and develop SCD, while those who inherit the gene from only one parent have the sickle-cell trait (SCT). (who.int)

My lab discovered 1 that a second form of clathrin in humans is specialized for trafficking the GLUT4 glucose transporter to an insulin-sensitive storage compartment in the cell. (nature.com)

Information about immunization requirements and recommendations related to travel can be found in the Canadian Immunization Guide . (canada.ca)

There is increasing evidence that malaria not only influences outcome but also changes the manifestations of sickle-cell anaemia in Africa. (who.int)
The overall outcome of the thymic selection is the maintenance of a T-cell repertoire that has sufficient, but not too strong, affinity for any self-pMHC complex ( 29 ). (frontiersin.org)

Median and mean peak IFN-γ T cell response by ELISPOT (spots per 10 4 CD8 + cells, Arm A/B/C) was 11/52/271 (A vs. C, p = 0.028) for medians and 37/148/248 (A vs. C, p = 0.032) for means. (bmj.com)

Considerable attention has been focused on the immune response in primary and secondary Flavivirus infection and the role of immunopathogenesis in the etiology of severe Flavivirus disease ( 11 , 15 , 16 ). (cdc.gov)

Such disorders, mainly thalassaemias and sickle-cell anaemia, are globally widespread. (who.int)
The outpatient countries are forced to adopt population-level widespread departments in the public sector, including primary, restrictions such as curfews and lockdowns, in order to secondary and tertiary level hospitals, were either closed limit contact between people to slow down transmission or only partially open during Mar to July 2020. (who.int)

A supplements and did not include outbreak response immunization (ORI) campaigns. (bvsalud.org)

Les anticorps du jaune d'œuf de poule (IgY), production et utilisation en immunisation passive contre les infections entériques bactériennes : une revue. (ac.be)
Avec l'interdiction de l'utilisation sub-thérapeutique des antibiotiques en Europe et la rigueur croissante de la législation européenne en matière d'hygiène alimentaire, l'immunisation passive par l'administration orale d'anticorps de jaune d'œuf (IgY) spécifiques du pathogène serait une alternative intéressante. (ac.be)
Cette synthèse bibliographique donne des informations concises sur la production des IgY et leur utilisation en immunisation passive, en particulier chez la volaille. (ac.be)

If approved, Yescarta will be the first Chimeric Antigen Receptor (CAR) T-cell therapy approved for patients in Europe who do not respond to first-line treatment. (gilead.com)
The 4-1BB receptor (CDw137), a member of the tumor necrosis factor receptor superfamily, has been shown to costimulate the activation of T cells. (rupress.org)

The invention provides means of inhibiting neutrophil release of extracellular traps by mesenchymal stem cells and/or exosomes derived from said mesenchymal stem cells. (therapeuticsolutionsint.com)
Additionally, synergies are provided between mesenchymal stem cells and/or exosomes derived from mesenchymal stem cells and agents approaches which reduce neutrophil extracellular trap formation. (therapeuticsolutionsint.com)
To determine safety and efficacy of 100 million intravenously administered CTEcells™ allogeneic umbilical cord mesenchymal stem cells. (therapeuticsolutionsint.com)
To determine safety and efficacy of intravenously administered allogeneic JadiCell umbilical cord blood mesenchymal stem cells in patients with moderate-to-severe COPD. (therapeuticsolutionsint.com)
Mesenchymal stem cells (MSCs) are the adult stem cells that have been studied in recent years and used to treat many diseases. (biomedcentral.com)
The human placenta-derived mesenchymal stem cells (hPMSCs) have gained wide attention due to their convenient isolation, less virus infection and low immunogenicity [ 8 ]. (biomedcentral.com)

Endeavours for controlling disability can be categorized as primary, secondary and tertiary prevention. (who.int)

The secondary objectives will be to assess all-cause mortality at Day 60, survival at day 31, number of subjects experiencing serious adverse events (SAEs) by day 31, SAE-free survival, time to recovery (evaluated until day 60), and time to oxygen requirement equal or below 40% oxygen. (therapeuticsolutionsint.com)
Secondary Objectives: To evaluate the effect of the Fludarabine-(etoposide, doxorubicin, vincristine, prednisone, cyclophosphamide) EPOCH regimen on host T cell depletion and myeloid depletion prior to allogeneic SCT. (drugpatentwatch.com)

Immunizations against infectious diseases are a particularly important component of care for individuals with HIV. (hivguidelines.org)
However, if an individual encounters the same infectious agent again, the "secondary response" is much quicker. (3d4medical.com)

This distribution reflects the fact that sickle-cell trait confers a survival advantage against malaria and that selection pressure due to malaria has resulted in high frequencies of the mutant gene especially in areas of high malarial transmission. (who.int)
The sickle-cell gene has become common in Africa because the sickle-cell trait confers some resistance to falciparum malaria during a critical period of early childhood, favouring survival of the host and subsequent transmission of the abnormal haemoglobin gene. (who.int)
Sickle-cell disease prevalence depends on sickle-cell trait. (who.int)

After induction in secondary lymphoid organs, a subset of antibody-secreting cells (ASCs) homes to the bone marrow (BM) and contributes to long-term antibody production. (silverchair.com)

They were formed in peripheral lymphoid organs during the initial infection but did not mature into antibody-secreting plasma cells. (3d4medical.com)

The Guardian spoke to this point in a recent article adding another aspect to the question, saying: "Human trials (have begun)… but even if they go well and a cure is found, there are many barriers before global immunisation is feasible. (financialnewsmedia.com)
These cells act as cytokine barriers. (schoolsonweb.com)

She became interested in clathrin, a protein that is key to both inward and outward membrane trafficking in cells, shortly after its isolation by Barbara Pearse. (wikipedia.org)
1 As an anti-BCMA CAR T cell therapy, Abecma recognizes and binds to BCMA, a protein that is nearly universally expressed on cancer cells in multiple myeloma, leading to the death of BCMA-expressing cells. (drugs.com)
When a cell gets infected, it prevents the spread of the microbes by secretion of a protein called interferon. (schoolsonweb.com)
The purified protein was used for immunization of a rabbit to produce specific polyclonal antiserum. (chxa.com)
When expressed as a recombinant protein in transfected cells, PV 3A cofractionates with endoplasmic reticulum markers ( 66 ), and its single transient expression can disrupt the secretory apparatus ( 23 ) and decrease major histocompatibility complex (MHC) class I expression ( 22 ). (asm.org)
Sickle-cell disease (SCD) is a genetic condition in which the red blood cells contain haemoglobin S (HbS), an abnormal form of the oxygen-carrying protein. (who.int)

Residing in an urban area and having post-secondary education were predictors of mobile phone ownership.Conclusion. (bvsalud.org)

The Secondary Endpoint, which is efficacy will be evaluated at baseline and days 30, 60, and 90. (therapeuticsolutionsint.com)

Duration of remission and relapse-free survival, overall survival, minimal residual disease (MRD) negativity rate, and alloSCT rate were assessed as secondary endpoints. (gilead.com)

Overall CR rate (CR + CRi), CR, and subsequent allogeneic stem cell transplant (alloSCT) rates remained unchanged since the prior data cut at 71%, 56%, and 20%, respectively. (gilead.com)
Allogeneic stem cell transplantation (SCT) results in a high percentage of complete remissions, but it can be associated with significant treatment-related mortality, which has been primarily attributed to conventional myeloablative transplant regimens. (drugpatentwatch.com)
To determine the treatment-related morbidity and mortality of allogeneic stem cell transplantation using a non-myeloablative conditioning regimen in multiple myeloma. (drugpatentwatch.com)

In other embodiments preservation of brain integrity in conditions of degeneration is accomplished by administration of stem cells and/or endothelial cells. (therapeuticsolutionsint.com)

Bristol Myers Squibb is now the only company with two approved CAR T cell therapies with distinct targets of CD19 and BCMA. (drugs.com)

On the other hand, T cells constitute the main pathogenic effector cells in delayed hypersensitivity reactions ( 4 - 6 ). (frontiersin.org)

Together, this study reveals that PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ to form an immunological barrier (F4/80 + PSTPIP2 hi cell-enriched zone) for the joints. (biomedcentral.com)

ZUMA-3 is an ongoing international multicenter (US, Canada, Europe), single arm, open label, registrational Phase 1/2 study of Tecartus in adult patients (≥18 years old) with ALL whose disease is refractory to or has relapsed following standard systemic therapy or hematopoietic stem cell transplantation. (gilead.com)
Refractory disease to first-line chemoimmunotherapy or relapse after first-line chemoimmunotherapy and are not eligible for hematopoietic stem cell transplant (HSCT) due to comorbidities or age. (wapakdailynews.com)

The T helper 2 (Th2) subset of CD4+ T helper cells secretes interleukin (IL)-4, IL-5, IL-6, and IL-10, which activates B cells and initiates the antibody response. (medscape.com)
Rather, the CD8+ T cell response induced by BNT162b2 was dependent on type I interferon-dependent MDA5 signaling. (stanford.edu)
We conducted a pilot randomized phase I trial in PC patients to determine the peptide dose required to induce an optimal CD8 + T cell response. (bmj.com)
Allergic reactions to drugs and chemicals are mediated by an adaptive immune response involving specific T cells. (frontiersin.org)
On one hand, drug-specific T cells provide the necessary help for mounting an effective B-cell response observed in immediate-type hypersensitivity reactions. (frontiersin.org)
However, attention has recently turned to the naive T-cell repertoire, since it may largely determine the efficacy of the induced immune response ( 22 ). (frontiersin.org)
It is now clear that the ability of T cells to promote an effective immune response depends on a large repertoire of unique T-cell receptors (TCRs) generated and selected in the thymus. (frontiersin.org)
We've discussed how the ability of the cells to have memory causes a secondary immune response. (schoolsonweb.com)

A descriptive cross-sectional study using semi-structured interviewer-administered questionnaires was conducted with 615 caregivers of infants, who brought their children to clinics conducting immunisation in 24 health facilities in rural, semi-urban and urban settlements in Ondo State in December 2014.Results. (bvsalud.org)

Abecma will be manufactured for each individual patient using the patient's own T cells at Bristol Myers Squibb's state-of-the-art cellular immunotherapy manufacturing facility in Summit, New Jersey. (drugs.com)
Breyanzi , a differentiated CAR T cell therapy, is made from a patient's own T cells, which are collected and genetically reengineered to become CAR T cells that are then delivered via infusion as a one-time treatment. (wapakdailynews.com)

The HK5.3 monoclonal antibody reacts with mouse ICOSL (inducible T cell co-stimulator ligand) also known as CD275, B7RP-1, and B7-H2. (bioxcell.com)

SANTA MONICA, Calif.--(BUSINESS WIRE)-- Kite, a Gilead Company (Nasdaq: GILD), today announced the three-year follow-up results from the pivotal ZUMA-3 study of the CAR T-cell therapy Tecartus ® (brexucabtagene autoleucel). (gilead.com)
Study to evaluate the efficacy of brexucabtagene autoleucel (KTE-X19) in participants with relapsed/refractory mantle cell lymphoma (ZUMA-2). (tecartushcp.com)

In one embodiment the invention teaches the treatment of chronic traumatic encephalopathy (CTE) through protecting/regenerating the endothelial by administration of cells such as stem cells. (therapeuticsolutionsint.com)
In one embodiment stem cells are administered in order to protect the endothelium from apoptosis and to preserve the blood brain barrier. (therapeuticsolutionsint.com)
In another embodiment stem cells are administered together with endothelial progenitor cells in order to regenerate neural endothelium. (therapeuticsolutionsint.com)
However, half of patients are not considered candidates for a stem cell transplant due to age and/or comorbidities, and only an estimated 25% of those who are candidates are able to receive a stem cell transplant and experience long-term clinical benefit. (wapakdailynews.com)
For patients who are not considered candidates for stem cell transplant, treatment options are limited. (wapakdailynews.com)

Abecma is a personalized immune cell therapy approved as a one-time infusion with a recommended dose range of 300 to 460 x 10 6 CAR-positive T cells. (drugs.com)
These findings provide a proof-of-concept strategy for the development of functional lympho-organoids suitable for restoring lymphatic and immune cell functions. (ethz.ch)

In 2009 the European Centre for Disease Control reviewed evidence for the optimal timing of DTP immunisation and due to the lack of available data, called for new studies to assess the differing schedules [ 9 ]. (biomedcentral.com)

There are, however, no firm data on the survival of patients with sickle-cell anaemia on the African continent. (who.int)
As our second FDA-approved CAR T cell therapy, Abecma underscores our commitment to deliver on the promise of cell therapies for patients who are battling aggressive and advanced blood cancers with limited effective treatment options. (drugs.com)
Now, with the approval of ide-celas the first anti-BCMA CAR T cell therapy, we are excited to finally be able to offer patients a new, effective personalized treatment option that is delivered through a single infusion. (drugs.com)
They are generally given to patients who have severe reactions to plasma (eg, severe allergies, paroxysmal nocturnal hemoglobinuria, IgA immunization). (msdmanuals.com)

Anatomy25

Organisms25

Diseases23

Chemicals and Drugs111

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Psychiatry and Psychology1

Phenomena and Processes26

Anthropology, Education, Sociology and Social Phenomena2

Information Science3

Named Groups2

Health Care11

Geographicals2

Vaccine13

Vaccination6

Antibodies11

Advisory Committee1

Abstract2

Responses16

Mice6

Diffuse large B-1

Adults2

Bacterial3

Immunology2

Antigen-prese3

IMMUNITY5

Routine2

Relapsed or refractory4

Pathogen2

Gene Expression2

Viral6

Replication1

Antigens5

Anamnestic response1

Malignancies2

Pertussis5

Serum2

Genes5

Humans1

Recommendations1

Outcome2

Median1

Primary and secondary1

Widespread2

Outbreak1

Passive3

Receptor2

Mesenchymal stem6

Prevention1

Objectives2

Infectious2

Sickle-cell3

Antibody secre1

Lymphoid organs1

Barriers2

Protein6

Predictors1

Endpoint1

Endpoints1

Allogeneic stem3

Endothelial cells1

Bristol-Myers1

Effector1

Macrophages1

Hematopoietic2

Response8

Infants1

Patient's2

Monoclonal1

Brexucabtagene autoleucel2

Stem5

Immune cell2

Schedules1

Patients4