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  • regulate
  • This is because BMPs regulate additional genes such as Id2 that counteract the effect of p21 on cell growth. (openthesis.org)
  • Based on overexpression studies and target gene analyses, the transcription factor DNA replication-related element factor (DREF) has been proposed to regulate growth and replication in Drosophila melanogaster. (nih.gov)
  • The groups of specialized cells that make up the various human tissues depend on an intricate communication network to regulate gene expression that in turn mediates growth, cell-type specific function, division, and programmed cell death. (wiley.com)
  • epithelial cells
  • Dogs can develop carcinomas of epithelial cells and organs, sarcomas of connective tissues and bones, and lymphomas or leukemias of the circulatory system. (wikipedia.org)
  • vitro
  • Plumbagin suppresses the migration and invasion of glioma cells via downregulation of MMP-2/9 expression and inaction of PI3K/Akt signaling pathway in vitro. (semanticscholar.org)
  • Furthermore
  • Furthermore, TAM67 reduced growth of established xenograft tumours from these cells in nude mice. (nih.gov)
  • Furthermore, Cln3 levels differ between mother and daughter cells, a difference that explains the asymmetry in cell cycle behavior between these two cell types. (wikipedia.org)
  • Furthermore, as one allele is already mutated in all other somatic cells, the future incidence of cancers in these individuals is observed with linear kinetics. (wikipedia.org)
  • CDK1
  • In fission yeast Schizosaccharomyces pombe (S. Pombe), cells divide at a defined, reproducible size during mitosis because of the regulated activity of Cdk1. (wikipedia.org)
  • inhibit
  • Moreover, 2-ME augmented COX-2 expression, suggesting that it may also inhibit SMC growth via prostaglandin formation. (ahajournals.org)
  • transcription
  • cJun, a major constituent of AP-1 transcription factor transducing multiple mitogen growth signals, is frequently overexpressed in non-small cell lung cancers (NSCLCs). (nih.gov)
  • When the appropriate signals have been received, cells commit to a new round of cell division by initiating transcription of G1 cyclins. (grantome.com)
  • replication
  • Cytokinesis M G 1 G 2 S Daughter cell START Bud emergence DNA replication Nuclear migration nuclear division Figure by MIT OCW. (coursehero.com)
  • The B period occurs between the completion of cell division and the beginning of DNA replication. (wikipedia.org)
  • The D period refers to the stage between the conclusion of DNA replication and the end of cell division. (wikipedia.org)
  • At the fastest growth rates, replication begins before the previous round of replication has completed, resulting in multiple replication forks along the DNA and overlapping cell cycles. (wikipedia.org)
  • When used in the context of cell development, the term refers to increase in cytoplasmic and organelle volume (G1 phase), as well as increase in genetic material (G2 phase) following the replication during S phase. (wikipedia.org)
  • During the G1 phase of the cell cycle, Cdc6 and Cdt1 recruit and load MCM2-7 to origins of replication (marked by the binding of Orc1-6) to form a stable and inactive complex called the pre-replication complex (pre-RC). (wikipedia.org)
  • The replication licensing system acts to ensure that the no section of the genome is replicated more than once in a single cell cycle. (wikipedia.org)
  • apoptotic
  • MGC-803 cells which were incubated with morphine also had a higher apoptotic rate than control cells. (biomedsearch.com)
  • These results suggest, for the first time, that AdRSVp16-mediated tumor suppression results from a combination of p16's multiple anti-tumor functions including p16's well-known anti-proliferation/cell division function, apoptotic and senescence induction function, and its lesser-known/under-investigated anti-angiogenesis function. (jcancer.org)
  • signals
  • The mechanisms that integrate external signals, cell growth, cell size and entry into cell cycle are poorly understood and represent a fundamental unsolved problem in cell biology. (grantome.com)
  • This network consists of extracellular signals interacting with the receptors of individual cells and determining the fate of each. (wiley.com)
  • Biology
  • How cells achieve the astonishing feat of appropriately sensing and responding to their environment has been a major question in biology. (merlot.org)
  • Marc W. Kirschner (born February 28, 1945) is an American cell biologist and biochemist and the founding chair of the Department of Systems Biology at Harvard Medical School. (wikipedia.org)
  • In 1993, he moved to Harvard Medical School, where he served as the chair of the new Department of Cell Biology for a decade. (wikipedia.org)
  • inhibitory effects
  • 2-Methoxyestradiol (2-ME), an endogenous metabolite of estradiol with no affinity for estrogen receptors, is a potent anticarcinogenic agent (in phase II clinical trials) and mediates the inhibitory effects of estradiol on smooth muscle cell (SMC) growth. (ahajournals.org)
  • This hypothesis is strengthened by our recent findings that 2-ME is a potent inhibitor of SMC proliferation and migration and extracellular matrix production 1 and that sequential metabolism of estradiol to methoxyestradiols, such as 2-ME, plays a major role in mediating the inhibitory effects of estradiol on SMC growth. (ahajournals.org)
  • These growth inhibitory effects of dehydrocostus lactone on BON-1 were found to be time and concentration-dependent. (termedia.pl)
  • Induction
  • B) Effects of the induction of TAM67 on cell cycle. (nih.gov)
  • The induction of TAM67 by doxycycline significantly reduced the percentage of cells in S phase, and increased that in G0/G1 phase in TAM67 #8, while the induction of GFP did not show such effects in GFP #3 (Figure 5B). (nih.gov)
  • Despite that, we demonstrated that p21 induction by other members of the superfamily, such as BMPs, is not sufficient for growth suppression. (openthesis.org)
  • regulatory
  • Cell Cycle and Growth Control, Second Edition offers both an introduction to important concepts and detailed discussion of regulatory mechanisms at the cellular, biochemical, genetic, and molecular levels. (wiley.com)
  • blockade
  • The purpose of this study is to determine the effects of AP-1 blockade on the growth of NSCLC cells using a cJun dominant-negative mutant, TAM67. (nih.gov)
  • Signaling
  • We further found that Rts1 is regulated by the yeast equivalent of the vertebrate PDK1/Akt signaling pathway, which plays conserved roles in the control of cell growth and entry into the cell cycle. (grantome.com)
  • An important focus of our work is the yeast equivalent of the vertebrate PDK1/Akt signaling pathway, which plays conserved roles in controlling cell growth and cell division. (grantome.com)
  • Phosphorylated forms of phosphatidylinositol (PI) are called phosphoinositides and play important roles in lipid signaling, cell signaling and membrane trafficking. (wikipedia.org)
  • human
  • The aim of this study was to determine the effects of nobiletin on the human U87 and Hs683 glioma cell lines. (semanticscholar.org)
  • Cells, regardless of whether they are in an organ in the human body or a component of a bacterial colony, can sense the chemical composition of the environment, the presence of neighboring cells, and even the types of their neighboring cells. (merlot.org)
  • Plant cells are much larger than animal cells, and protists such as Paramecium can be 330 μm long, while a typical human cell might be 10 μm. (wikipedia.org)