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  • inhibits
  • This covalent modification of the molecular structure of Cdc2 inhibits the enzymatic activity of Cdc2 and prevents cell division. (wikipedia.org)
  • The protein kinase Cdr2 (which negatively regulates Wee1) and the Cdr2-related kinase Cdr1 (which directly phosphorylates and inhibits Wee1 in vitro ) are localized to a band of cortical nodes in the middle of interphase cells. (wikipedia.org)
  • Thus, SAMe inhibits the mitogenic effect of growth factors such as hepatocyte growth factor and, following partial hepatectomy, a fall in SAMe level is required for the liver to regenerate. (nih.gov)
  • These findings will guide future research at Dr. Wurtele's laboratory to determine how this new class of drugs inhibits the growth of cancer cells. (medindia.net)
  • bacteria
  • Bio- Respirometer to measure cell culture or bacteria growth New Respirometer can also be used to measure respiration of algae, fungi, oxidation of food products, bacterial response to antibiotics and toxins, respiration of soil, compost etc. (bio.net)
  • They discovered that as bacteria grow the cell populations naturally form striking and unexpected branching patterns called fractals. (cam.ac.uk)
  • chemotherapy
  • About 30% of breast cancer patients have Her-2/neu receptors (Human Epidermal Growth factor Receptor type 2), which are severe kind of breast cancer that are more aggressive and the activation of the receptors makes the cancer cells to grow and these patients do not respond effectively as negative receptors to chemotherapy and/or anti-estrogen therapy such as tamoxifen. (medindia.net)
  • The research team had earlier found that gamma linolenic acid enhanced the action of tamoxifen and chemotherapy drugs against cancer cell. (medindia.net)
  • Professor Menendez said, " Since over-expression of Her-2/neu generally confers resistance to chemotherapy and endocrine therapies, our current findings can explain why GLA increases the efficacy of breast cancer treatments and it has been found that an inexpensive herbal medicine can regulate breast cancer cell growth and help control cancer spread. (medindia.net)
  • The experiments demonstrate that Class III HDACs, which influence various cellular processes involved in carcinogenesis and response to chemotherapy agents, strongly block cell proliferation by preventing the normal functioning of various factors involved in the response to DNA damage spontaneously generated by cellular metabolism. (medindia.net)
  • therapies
  • Acceptance of this core patent gives tremendous strength to Histogen's technology and products, and establishes them as unique from any other cell-derived therapies in development today," said Dr. Gail Naughton, CEO and Chairman of the Board for Histogen. (prweb.com)
  • Stem cells are increasingly being used as cell therapies for a range of diseases that cannot be reliably treated by conventional medicine including skeletal tissue injuries, heart attacks, degenerative diseases and organ failure," Dr Yeo explained. (eurekalert.org)
  • Unfortunately, a lack of supply is hindering widespread use of such cell therapies. (eurekalert.org)
  • Such technologies can help significantly lower the currently prohibitive cost of many cell therapies. (eurekalert.org)
  • gene
  • It also influences the pattern of gene expression of the cells in which it is in contact. (corning.com)
  • UCLA geneticists have discovered a gene involved in cell growth. (emaxhealth.com)
  • Interestingly, the mutation causing the syndrome occurs on the same gene that causes Beckwith-Wiedemann syndrome, which makes cells grow too fast, resulting in unusually large children. (emaxhealth.com)
  • This protein is central to cell division and survival, and mutations in the gene that codes for Ras are a common cause of human malignancies. (eurekalert.org)
  • Undergraduate and graduate students in Bezanilla's plant biology classes at UMass Amherst, including the many underrepresented minority students who attend summer institutes, will benefit from taking part in these studies because they will learn about gene transcription and translation among other topics, and receive training in RNA-induced gene silencing, fluorescent protein labeling, using DNA to transform cells, molecular cloning, microscopy and other laboratory techniques. (umass.edu)
  • molecules
  • The multipotent cells secrete a variety of soluble and insoluble molecules associated with stem cell niches in the body, as well as rapid tissue regeneration and scarless healing. (prweb.com)
  • In an article appearing in Science (4 September issue), H.-J. Song and colleagues report that they are able to manipulate growth cones into eliciting either attraction or repulsion to each other, depending on the amount of two signalling molecules, cAMP and cGMP, present in the cells. (alzforum.org)
  • AMHERST, Mass. - Plant cell biologist Magdalena Bezanilla at the University of Massachusetts Amherst has received a four-year, $600,000 grant from the National Science Foundation to further her award-winning research on fundamental processes of plant growth, in particular how molecules secreted by cells help to determine their outer shapes and patterns. (umass.edu)
  • substrates
  • In a Nature Materials paper in 2010, Mei and Saha reported inducing significant increases in cell growth by using synthetic polymer substrates with high content of hydrocarbon and ester groups. (medindia.net)
  • Cell culture investigation demonstrates that the hydroxyapatite substrate is able to provide favourable cell attachment and collagen matrix production, as compared to the commonly used cell culture control substrates. (hindawi.com)
  • support stem
  • The last paper is trying to figure out what is the correct, optimum surface chemistry to support stem cells," says Mei, a research associate in the labs of Robert Langer and Daniel Anderson in MIT''s chemical engineering department. (medindia.net)
  • cellular
  • Cancer cells exhibit altered cellular functions compared to the normal functioning, non-malignant cells from which they are derived. (corning.com)
  • Precisely manufactured to conform to the automation-friendly ANSI/SBS format, BactiGrowth plates are available in plate formats from 24- to 384-well, and well volumes from 300 µL to 10 mL-suitable for most cellular growth applications. (genengnews.com)
  • biological
  • The term cell growth is used in the contexts of biological cell development and cell division (reproduction). (wikipedia.org)
  • They used cell biological, genetic and biochemical techniques to show how a specific part of the toxin, an effector domain called DUF5Vv, targets and cleaves Ras. (eurekalert.org)
  • chromatin
  • Cells can chemically modify histones so as to change chromatin structure and thereby control the various functions of DNA. (medindia.net)
  • keratinocytes
  • One year later, a Chesebrough-Ponds patent 6 disclosing cosmetic compositions containing phytovitamin D 3 contained a discussion of keratinocytes, which constitute 75-80% of the total number of cells in the human epidermis. (cosmeticsandtoiletries.com)
  • isolate
  • They have developed a technique to routinely isolate and propagate these stem cells in an artificial environment. (tinnitusformula.com)
  • We don't need to isolate specialized cell groups, so it is easier to study this in plants," the biologist notes. (umass.edu)
  • genetic
  • Hair cell loss is caused by exposure to excessive noise, aging, genetic mutations, autoimmune disease, and ototoxic medications such as aminoglycoside antibiotics. (tinnitusformula.com)
  • In mammals, attempts to regenerate damaged inner ear hair cells by genetic means have previously resulted in limited success. (tinnitusformula.com)
  • When used in the context of cell development, the term refers to increase in cytoplasmic and organelle volume ( G1 phase ), as well as increase in genetic material ( G2 phase ) following the replication during S phase . (wikipedia.org)
  • This number tells you what percentage of cells in the sample are in the process of copying their genetic information, or DNA. (breastcancer.org)
  • While mechanisms governing plant cell growth are known to exist, the genetic origins of such mechanisms have remained unclear. (innovations-report.com)
  • The premature entry of a cell into the S phase is a potential cause of genetic instability, which in turn can propel a cell into uncontrolled proliferation, resulting in cancer. (scienceblog.com)
  • rapidly
  • Published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS), co-authors Dr Giselle Yeo and Professor Anthony Weiss - from the University of Sydney's Charles Perkins Centre, School of Life and Environmental Sciences and Bosch Institute - said the study describes a new and cost-effective method of growing and recruiting mesenchymal stem cells rapidly and efficiently. (eurekalert.org)
  • These cells are large columnar, rapidly proliferating cells. (cosmeticsandtoiletries.com)
  • divisions
  • If the nutrient supply is restricted (after time t = 2 in the diagram, below), and the rate of increase in cell size is slowed, the time period between cell divisions is increased. (wikipedia.org)
  • Despite bacterial colonies always forming circular shapes as they grow, their cells form internal divisions which are highly asymmetrical and branched. (cam.ac.uk)
  • Bone
  • A drug used to treat the bone-thinning disease osteoporosis appears to help block the growth of breast cancer cells. (netdoctor.co.uk)
  • Although unrelated, the boys both had similar growth problems: minimal fetal development, stunted bone growth, sluggish adrenal glands, and undersized organs. (emaxhealth.com)
  • Although having low porosity, the hydroxyapatite scaffold was found to be capable of sustaining cell growth and thus assisting bone ingrowth. (hindawi.com)
  • In animals, secretion of extracellular matrix may lead to the formation of bone or an outer shell, for example, but because only a subset of cell types build these complex structures in a single organism, it can be difficult to study these processes in animals. (umass.edu)
  • Thus
  • Thus, each generation of cells should be twice as numerous as the previous generation. (wikipedia.org)
  • When cells have reached sufficient size during G2, the phosphatase Cdc25 removes the inhibitory phosphorylation, and thus activates Cdc2 to allow mitotic entry. (wikipedia.org)
  • This knowledge may be used in the future to down-regulate (decrease the activity of) Skp2 in cancers, and thus to arrest the growth of these cancers. (scienceblog.com)
  • increases
  • Understanding how plant cells grow and develop is essential to achieving increases in the size and yield of crops, one of the fundamental goals of plant science research. (innovations-report.com)
  • grow and divide
  • This is repeated as the cells continue to grow and divide, leading to the formation of rafts of aligned cells arranged in self-similar branching patterns, or fractals. (cam.ac.uk)
  • Assay
  • The growth of the 22Rv1 and PC‑3 cell lines, as assessed with a trypan blue exclusion assay, was markedly inhibited by OBZ treatment in vitro, with half‑maximal inhibitory concentration values of 0.25 and 0.64 µM, respectively. (spandidos-publications.com)
  • human
  • Plant cells are much larger than animal cells, and protists such as Paramecium can be 330 μm long, while a typical human cell might be 10 μm. (wikipedia.org)
  • This study evaluates the effectiveness of Corning Synthemax surface to culture human iPS cells. (corning.com)
  • A new surface created by Whitehead Institute and MIT scientists is capable of tripling the growth of human embryonic stem (ES) and induced pluripotent stem (iPS) cells in culture by current methods. (medindia.net)
  • By growing cells under proprietary conditions that simulate the embryonic environment, particularly hypoxia, it has been shown that normal human fibroblast cells become multipotent, and express key stem cell markers including Oct4, Sox2 and Nanog. (prweb.com)
  • In addition, the human multipotent cell conditioned media produced through Histogen's technology process can be found in the ReGenica line of skincare products by Suneva Medical. (prweb.com)
  • In the present study, the capability of OBZ to repress the growth of PCa cells was assessed in human androgen‑independent PCa 22Rv1 and PC‑3 cell lines. (spandidos-publications.com)
  • migrate
  • The hallmark of metastatic cells is their ability to invade through the basement membrane and migrate to other parts of the body. (corning.com)
  • study
  • By harnessing this ability, scientists can use ES and iPS cells to create cell lines that model difficult-to-study diseases, such as Parkinson''s and Alzheimer''s, and screen for potential drugs for these diseases. (medindia.net)
  • The study by Dr. Wurtele's research team and collaborators used yeast as a model system to understand, at a molecular level, the mechanisms that influence cell growth in the presence of a particular class of HDACs. (medindia.net)
  • These fractal (self-similar) patterns are due to the physical forces and local instabilities that are a natural part of bacterial cell growth, a new study reveals. (cam.ac.uk)
  • A tumor cell lacks the ability to limit its own growth," says Michele Pagano, M.D., Associate Professor of Pathology, who led the new study published in the March 11 issue of Nature. (scienceblog.com)
  • This is a very important and exciting study," says Avram Hershko, M.D., Ph.D., Distinguished Professor at Technion-Israel Institute of Technology in Haifa, who has made seminal contributions to understanding protein degradation and the cell cycle, the sequence of events a cell undergoes to make a copy of itself by dividing into two. (scienceblog.com)
  • In Dr. Pagano's latest study, his group demonstrated that cells with high levels of a mutated form of Skp2 promoted the degradation of p27. (scienceblog.com)
  • Genetics
  • Dr Haseloff added: "This is an experimental system that can capture the physics, cellularity and genetics of growth in a simple system - and which allows a new type of 'emergence in a test-tube' approach. (cam.ac.uk)
  • types of cells
  • Stem cells are unique types of cells that have the ability to renew themselves over long periods of time. (tinnitusformula.com)
  • Our discovery - that tropoelastin dramatically promotes stem cell expansion and recruitment, and reliably preserves their ability to develop into different types of cells - points to new ways of cost-effectively and efficiently growing these stem cells to address the increasing global demand. (eurekalert.org)
  • they are made of many different types of cells that reproduce very quickly and receive a significant blood supply. (medicalnewstoday.com)
  • microscopy
  • Led by electrical and computer engineering professor Gabriel Popescu, the research team developed a new imaging method called spatial light interference microscopy (SLIM) that can measure cell mass using two beams of light. (innovations-report.com)
  • Unlike most other cell-imaging techniques, SLIM - a combination of phase-contrast microscopy and holography - does not need staining or any other special preparation. (innovations-report.com)
  • It uses white light and can be combined with more traditional microscopy techniques, such as fluorescence, to monitor cells as they grow. (innovations-report.com)
  • patients
  • If you were one day to inject these cells into patients, you wouldn''t have to worry about as many safety risks as if you had co-cultured them with animal cells. (medindia.net)
  • feeder
  • For example, Matrigel matrix , coupled with a variety of culture media, has been widely accepted as an alternative substrate to feeder-dependent culture of hESCs, and it has been used to culture induced pluripotent stem (iPS) cells. (corning.com)
  • Use of this novel surface also eliminates the need for layers of mouse "feeder cells" to support ES- and iPS-cell growth. (medindia.net)
  • Polystyrene is the most common cell culture surface used in labs, and to be able to do a simple treatment and get something that works better than the mouse feeder layers is great and potentially has a lot of utility," says Daniel Anderson, Associate Professor in the Harvard-MIT Division of Health Sciences & Technology. (medindia.net)
  • Saha and Mei found that a mere 2.5 minutes of UV irradiation produced the impressive growth rates in the absence of feeder cells. (medindia.net)
  • ECGS often fully substitutes for feeder layers in culture of fastidious cells. (fishersci.com)
  • culture
  • Growth factors were then withdrawn and the culture was continued in a defined medium. (tinnitusformula.com)
  • From cell culture reagents such as Matrigel high concentration to membrane insert systems, like Falcon® permeable supports , discover how Corning cell culture products can help you gain greater insights into tumor cell growth, morphology, and migration. (corning.com)
  • Although successful, that process is less practical for large-scale production because the required polymers are difficult to synthesize in various cell culture formats. (medindia.net)
  • scientists
  • Some scientists estimate that such techniques would require millions or even billions of cells, but current cell cultivation methods thwart efficient production of such mass quantities. (medindia.net)
  • developmental
  • Unlike earlier studies, the teams focused on later stages in the trichome developmental process, which are accompanied by rapid cell growth and branching. (innovations-report.com)
  • Co-authors on the paper include graduate students Zhuo Wang, Zhen Shen and Michael Bednarz, along with electrical and computer engineering professor Rashid Bashir, physics professor Ido Golding and cell and developmental biology professor Supriya G. Prasanth. (innovations-report.com)
  • survive
  • However, the number of generations only gives a maximum figure as not all cells survive in each generation. (wikipedia.org)
  • Understanding
  • This basic research allows for a better understanding of the overall effects of HDAC inhibitors on cells and can eventually lead to an optimization of their clinical use," said Dr. Wurtele. (medindia.net)