Cell enlargement and tissue differentiation. Medical search. Frequent questions

Histologically, a monoclonal proliferation of smooth muscle cells occurs. (medscape.com)
Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. (cusabio.com)
WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
The researchers were able to show that stromal cells surrounding the gland base continually inhibit the BMP signaling pathway, thereby stimulating the proliferation of nearby stem cells. (charite.de)
In contrast, stromal cells at the gland surface were found to activate the signaling pathway, thereby suppressing cell proliferation. (charite.de)
This inflammatory cytokine interferes with the BMP signaling axis, resulting in less BMP signaling activity and stimulating gland stem cell proliferation. (charite.de)
Prostate cancer can develop through the malignant degeneration and proliferation of prostate cells. (spitalmaennedorf.ch)
Long non-coding RNAs (lncRNAs) and miRNAs belong to a class of non-coding RNAs (ncRNAs) that play important roles and functions in the regulation of the expression of genes in main biological processes, such as cell proliferation, apoptosis, and differentiation. (ac.ir)
Regeneration can occur in some simple glands by proliferation and differentiation of ductal cells. (iastate.edu)

In this study, we aimed to examine whether TBS can inhibit high-fat diet (HFD)-induced adipogenesis in the liver and epididymal adipose tissue of obese mice. (biomedcentral.com)
Oral administration of TBS significantly reduced body weight and decreased epididymal and visceral white adipose tissue (WAT) weight. (biomedcentral.com)
Obesity is characterized by excessive growth in adipose tissue mass and is rapidly becoming a public health problem that affects millions of people worldwide [ 1 ]. (biomedcentral.com)
Due to an imbalance between energy intake and expenditure, obesity gives rise to excessive growth and expansion of adipose tissue [ 3 ]. (biomedcentral.com)
Thus, the inhibition of adipose tissue enlargement can be an important target in order to prevent and treat obesity. (biomedcentral.com)
White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in regulating energy homeostasis and insulin sensitivity. (springer.com)
Conversely, brown adipose tissue (BAT) and browning of WAT represent potential therapeutic approaches, since dysfunctional white adipocyte-induced lipid overspill can be halted by BAT/browning-mediated oxidative anti-lipotoxic effects. (springer.com)
Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities. (springer.com)
White adipose tissue (WAT) plays a key homeostatic role, not only by ensuring efficient energy storage but also by its quick mobilisation (lipids) to ensure peripheral demands. (springer.com)
The 'adipose tissue expandability model' identifies the limited capacity and dysfunctionality of WAT, preventing its expansion and accommodation of surplus of energy, as key determinants for the onset and progression of obesity-associated metabolopathologies as a result of ectopic deposition of toxic lipid species in metabolic organs (i.e. muscle or liver [also known as lipotoxic insult]) [ 7 ]. (springer.com)
There is also evidence that the deleterious effects mediated by dysfunctional white adipocyte-induced lipid overspill can be halted by the pro-oxidative anti-lipotoxic effects mediated by brown adipose tissue (BAT) activation. (springer.com)
Fat cells in adipose tissue only contain growth hormone receptors. (nwac-hq.org)
The end result is loss of adipose tissue that leads to the desired slimming effect and more definition of muscle gains. (nwac-hq.org)
We want to understand how obesity-induced changes to fat tissue (white adipose tissue) lead to comorbidities such as cancer and diabetes. (utah.edu)
In response to excess calories, white adipose tissue has to expand, and this requires the coordinated enlargement of existing fat cells as well as the generation of additional fat cells. (utah.edu)
Adipose tissue becomes dysfunctional when excess calories exceed the capacity of fat stem cells to generate enough new fat cells, resulting in over-enlargement of existing fat cells and consequently tissue fibrosis, inflammation, and insulin insensitivity. (utah.edu)
Strikingly, loss of cilia on fat stem cells prevents their differentiation and the proper expansion of white adipose tissue. (utah.edu)
We want to understand the localized, reciprocal signaling network between cancer cells and the cells in white adipose tissue. (utah.edu)
We are particularly interested how signals secreted by breast cancer cells change the composition and function of the surrounding white adipose tissue, and how signals secreted by obese white adipose tissue promote breast cancer growth. (utah.edu)
By focusing on intercellular signaling networks connecting cancer cells and white adipose tissue, we can uncover novel targetable modulators of tumorigenesis in general and obesity-accelerated breast cancer in particular. (utah.edu)
HO-1 also serves as the mediator of cross-talk between adipose tissue and the vasculature. (nymc.edu)

EETs upregulate HO-1-adiponectin-AKT signaling and play essential roles in the regulation of adipocyte differentiation, indicating the existence of a crosstalk between HO-1 and EETs. (nymc.edu)

Leiomyomas of the uterus (or uterine fibroids) are benign tumors that arise from the overgrowth of smooth muscle and connective tissue in the uterus. (medscape.com)
Ovotestes are usually compartmentalized, with connective tissue separating the ovarian components from the testicular components. (medscape.com)
Fibrotic tissues shows increased amount of connective tissue. (bvsalud.org)
It is characterized by densely arranged collagen bundles, numerous fibroblasts, and connective tissue which is avascular along with well structured epithelium with elongated and thin papillae inserted in fibrous connective tissueeeee 2 . (bvsalud.org)
Hepatic Fibrosis Hepatic fibrosis is overly exuberant wound healing in which excessive connective tissue builds up in the liver. (msdmanuals.com)

Auxins helps in establishing contact between vascular tissues of the callus and that of the bud and makes it possible for the bud to grow properly in callus. (agrilearner.com)
He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
EET/HO acts as a molecular "switch" to genetically reprogram adipocyte stem cells and, subsequently, vascular endothelium through activation of a unique signaling cascade that results in the amplification of protective circuits and provides resistance to vascular dysfunction. (nymc.edu)
We believe that the effect of anti-diabetic drugs alone, or in combination with antioxidant genes, have a differential impact on stem cell function and vascular disease. (nymc.edu)
Meristematic tissues include Stem and root apices, vascular cambium and cork cambium. (neetexambooster.in)
Vascular tissues in flowering plants develop from Plerome. (neetexambooster.in)
Ground tissue includes All tissue except epidermis and vascular bundle. (neetexambooster.in)

The least differentiated of these tumors, embryonal rhabdomyosarcoma, is composed of small, round cells and in the past may be mistaken histopathologically for lymphoma, melanoma, and fibrosarcoma, among others. (radiologykey.com)
Ovarian tumors include luteoma of pregnancy, arrhenoblastoma, hilar-cell tumor, masculinizing ovarian stromal cell tumor, and Krukenberg tumor. (health.am)
Poromas are often grouped within the greater classification of acrospiroma, which includes dermal duct tumors, hidroacanthoma simplex, and nodular, clear-cell, and poroid hidradenomas. (clinicaladvisor.com)

Thenceforth, our bodies develop down one of the two reproductive pathways - a female pathway, characterised typically by 46 XX karyotype, which influences sexual differentiation to support production of eggs, and a male pathway, characterised typically by 46 XY karyotype, which influences sexual differentiation to support production of sperm. (can-sg.org)
Male sexual differentiation relies on the presence of Anti-Müllerian Hormone (AMH), produced by the testes. (can-sg.org)
Other drugs, like danazol, which are also used in pregnancy, have been associated with abnormalities of sexual differentiation. (health.am)
Detection of mutations in this gene has confirmed the fundamental role of aromatase for the fetal-placental unit and for sexual differentiation of the female fetus. (health.am)

His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
Thereafter, I led a productive research that further characterized the biochemistry of heme oxygenase and the implication of its activity to heme and iron homeostasis and the function of hematopoietic stem cells. (nymc.edu)

There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
There his work focused on transcriptional control of hematopoietic stem cell maturation and cell fate. (ubc.ca)
In a longitudinal section of a root, starting from the tip upward, the four zones occur in the following order Root cap, cell division, cell enlargement, cell maturation. (neetexambooster.in)

Fgf18 has been reported to have anabolic effects on chondrocytes in other cartilaginous tissues like auricular cartilage, bronchial cartilage, and costal cartilage in animal models. (cusabio.com)
The close resemblance between terminal differentiation in OA cartilage and EO shows that fresh OA therapeutic focuses on can potentially become determined from EO biology. (exposed-skin-care.net)
The Wnt signaling pathway can be well established to be always a crucial regulator in EO [13,14], an activity through which bone tissue and articular cartilage are shaped. (exposed-skin-care.net)

Here, the resistors R e and R i represent the extracellular and intracellular space, respectively, and the capacitance C m represents the blocking behavior of the cell membrane. (uni-stuttgart.de)
Flow cytometric detection of intracellular antigens has become a standard method in establishing proper leukemic cell lineage affiliation. (ijpmonline.org)
Detection of intracellular antigens by flow cytometry (FCM) requires effective fixation and permeabilization of the cell membrane. (ijpmonline.org)
BK channels are activated by both cell membrane depolarization and increases in intracellular calcium, allowing them to function as coincidence detectors that integrate intracellular calcium levels and membrane voltage. (health-e-nc.org)
The intracellular virus causes marked enlargement and destruction of many infected cells but persists and is tolerated by other cells. (iastate.edu)
I-FABP) and bovine heart fatty acid-binding pro- tissues and in intracellular as well as extracellular tein (H-FABP). (lu.se)

HIFU is a noninvasive treatment whereby uterine fibroids are thermally ablated by concentrating ultrasound energy on a small area, resulting in coagulation necrosis and destruction of selected tissue. (medscape.com)
The clinical picture comprises a painful cellulitis with minimal or imperceptible port of entry, deep abscesses, and tissue necrosis. (cdc.gov)
One month later, there was continued enlargement of the lung nodule and mediastinal adenopathy with necrosis. (cdc.gov)
Endothelial cell damage and necrosis is believed to be responsible for the petechial hemorrhages and edema that accompany IBR. (iastate.edu)

Histologically a circumscribed tumor with lakes of mucin, neoplastic cells arranged in strands and nests, and apocrine secretion is frequently observed ( Fig-1 ) [4]. (asploro.com)
Increased HO-1 expression and HO-1 activity is associated with an increase in adiponectin secretion that prevent differentiation and enlargement of adipocytes resulting in the stimulation of nitric oxide (NO) bioavailability and improved endothelial function and glucose tolerance. (nymc.edu)
Although the histological features of apocrine and eccrine poromas are nearly identical, the presence of homogenous eosinophilic intraluminal secretion, lining cells with intensely eosinophilic cytoplasm, and small clusters of sebaceous cells surrounded by poroid cells is suggestive of apocrine lineage. (clinicaladvisor.com)

By focusing on signaling pathways that are mediated by the primary cilium, we can (a) leverage advances in human genetics associated with ciliopathies to drive new hypotheses, (b) exploit the specific localization of ciliary receptors to mechanistically interrogate these signaling pathways, and (c) begin to understand how the primary cilium integrates signals for binary cell fate decisions. (utah.edu)
Due to the mutual relationships among lncRNA, miRNA, and mRNA, our results provided a novel perspective on lncRNAs for future research and experimental studies on ectodermal differentiation pathways and molecular mechanisms. (ac.ir)
In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)

In multiple organs, including the lungs, age-related tissue and organ dysfunction interferes with tissue regeneration, which requires functional stem cells. (karger.com)
Stem cells of all organs - including the lung, which harbors distinct stem cells for each separate tissue that makes up the lung as a whole - reside in niches described as a microenvironment that supports and maintains the 'stemness' of cells as a critical reservoir for maintaining tissue homeostasis and responding to injury [ 3 ]. (karger.com)
The protein is active in the neural crest, which is a group of cells in the early embryo that give rise to many tissues and organs. (medlineplus.gov)
Lymphatic tissue or circulating lymphocytes may also be located in other regions of the body, such as the skin, small intestine, liver, and other organs. (rarediseases.org)
Caused by damage to brain cells rather than deficits in speech or hearing organs. (brainline.org)

The differential diagnosis is made with the benign forms of infantile fibromatoses rich in cells and other infantile sarcomas particularly the congenital rhabdomyosarcoma more aggressive [2, 3]. (jortho.org)
Often, other causes such as benign prostate enlargement can also be behind it. (spitalmaennedorf.ch)
Differentiation from other even benign orbital lesions on the basis of this study is impossible. (radiologykey.com)
Hereditary gingival fibromatosis is a rare disease (1 in 750,000) and belongs to a group of benign disorders characterized by firm, enlarged gingival tissues that cover most of the anatomic crowns. (bvsalud.org)

This report demonstrates the limitations of currently used histopathological and immunohistochemical differentiation in metastatic mucinous carcinoma. (asploro.com)
Given these results, the authors discuss the difficulty in diagnosing differentiation from a primary or metastatic neoplasm of the scalp, with the resources currently available, until the conclusion that it was a primary carcinoma of the sweat gland. (bvsalud.org)

In the case of breast cancer, approaches already exist for classifying healthy and malignant tissue using neural networks or linear discriminant analysis. (uni-stuttgart.de)
7. Gerrard L, Rodgers L, Cui W. Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signaling. (ac.ir)
Neural crest cells migrate to form parts of the autonomic nervous system, many tissues in the face and skull, and other tissue and cell types. (medlineplus.gov)

Auxins facilitate cell division and root differentiation. (agromaster-eg.com)
Auxins induce cell division, cell elongation, and formation of callus in cultures. (agromaster-eg.com)

The tissue is fibrotic (feels like bone on palpation) and displays a nodular or minutely pebbled surface. (bvsalud.org)
Cirrhosis is characterized by regenerative nodules surrounded by dense fibrotic tissue. (msdmanuals.com)

apoptosis - cell death that occurs naturally as part of normal development, maintenance, and renewal of tissues within an organism. (brainline.org)

1 - 4 Immunohistochemical studies have, however, eliminated most of the ambiguity in the diagnosis of "small round cell" and "spindle cell" lesions. (radiologykey.com)

Extreme enlargement of the uterus resulting from fibroids may be seen as a nonspecific soft-tissue mass of the pelvis that possibly displaces loops of bowel. (medscape.com)
An unusual skin and soft tissue infection of the lower limbs has been observed in immigrants from sub-Saharan Africa who cross the Atlantic Ocean crowded on small fishing boats ( pateras ). (cdc.gov)
Among the varied medical problems affecting these young, previously healthy immigrants are unexpectedly high numbers of severe skin and soft tissue infections (SSTIs), especially those involving the feet and legs. (cdc.gov)
The congenital fibrosarcoma is a malignant tumour of the soft tissue. (jortho.org)
The X ray of the hand showed a swelling of the soft tissue with associated cortical thickening of carpal, metacarpal and phalangeal bones. (jortho.org)
Standard X ray of the left hand noted soft tissue swelling [Figure 1] and cortical thickening of carpal, metacarpal and phalangeal bones. (jortho.org)
The tumour elective sites are the distal part of the arms, more on the lower than the upper [1].The tumour developed initially in the soft tissue. (jortho.org)
The diagnosis is sometimes made base on a fast growing soft tissue swelling. (jortho.org)
The standard X ray showed an important soft tissue swelling. (jortho.org)
In children, it is the most common soft tissue malignancy of the head and neck occurring predominantly in patients between 2 and 12 years of age. (radiologykey.com)

There was no myoblastic differentiation in the cytoplasm. (jortho.org)

Hyperplasia is the formation of new muscle cells through cellular reproduction, while hypertrophy is increase in the size of preexisting muscle cells. (nwac-hq.org)
This results in hyperplasia, a precancerous lesion characterized by tissue enlargement. (charite.de)
Leydig cell hyperplasia may also occur with aging. (medscape.com)

This means that the current flows around the cells at low frequencies (path via R e ) and can only penetrate the cell membrane above a certain threshold value. (uni-stuttgart.de)
Nevertheless, when Wnt ligands bind to cell membrane receptors, signaling through the frizzled receptors inhibits this degradation procedure, thereby raising the degrees of free of charge cytoplasmic -catenin. (exposed-skin-care.net)
When Wnt ligands bind with their cognate cell membrane receptors, indicators are released to inhibit this degradation procedure, leading to -catenin build up and nuclear translocation controlled by Rac1, DKK1 and FRZB, which are antagonists of canonical Wnt signaling. (exposed-skin-care.net)
the tegmen is a transparent membrane tissue. (atikaschool.org)

By recreating the microenvironment for endocrine cell development in the lab, we may be able to achieve a long-standing goal in diabetes research - to efficiently produce fully functional glucose-responsive endocrine cells from a patient's stem cells. (cshlpress.com)
This strategy enabled them to study the effects of various signals on stem cells which are found inside the gastric glands (and which are capable of differentiating into many different cell types). (charite.de)
We want to understand what physiological signals activate fat stem cells, how these signals trigger the differentiation of fat stem cells, and why not enough fat stem cells are activated in disease. (utah.edu)
We discovered that fat stem cells (like most stem cells) have an antenna-like cellular protrusion called a primary cilium. (utah.edu)
We want to identify what receptors localize to the primary cilium of fat stem cells, what physiological signals they sense, and how they regulate the activation and differentiation of fat stem cells. (utah.edu)
Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging. (utah.edu)
In this study, mRNA, miRNA, and lncRNA gene networks were predicted by web-based programs for three ectodermal pathway markers (BMP4, NOG, FGF8) in the mouse embryonic stem cells. (ac.ir)
Stem cells. (ac.ir)
Stem cells are characterized by their ability to undergo self-renewal to maintain stem cell reserves, and, when required, to produce new, terminally differentiated cells. (karger.com)
During aging, a decline in organ function can be traced to a loss of stem cell function due to increased cell turnover, depletion of stem cells, and alterations to the stem cell niche. (karger.com)

Other small-cell, so-called squamous or mucinous carcinomas are very rare. (spitalmaennedorf.ch)

Delay in abscision and differentiation of xylem elements. (agrilearner.com)
The balloon shaped structures called tyloses are extensions of xylem parenchyma cells into vessels. (neetexambooster.in)

In this project, the differentiation of healthy and malignant tissue based on impedance spectroscopy will be investigated and further developed. (uni-stuttgart.de)
MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
Rapid enlargement, ulceration, spontaneous bleeding, and pain are signs that the lesion may be developing into its malignant counterpart, porocarcinoma. (clinicaladvisor.com)

These effects seem to be because of the direct action on mature chondrocytes rather than on the progenitor cells. (cusabio.com)
Regular articular chondrocytes located in the ends of lengthy bones usually do not become the hypertrophic condition, thus staying away from terminal differentiation. (exposed-skin-care.net)

The expansion of WAT is a complex process that involves the enlargement of existing adipocytes and an increased number of adipocytes through adipogenesis ( 4 ). (diabetesjournals.org)

Cytokinins promote RNA synthesis and stimulate protein and enzyme activities in tissues. (agromaster-eg.com)

Cytokinins induce cell division and differentiation. (agromaster-eg.com)

Indole3acetic acid (IAA) is the main auxin in plants, controlling many important physiological processes including cell enlargement and division, tissue differentiation, and responses to light and gravity (45). (nacchemical.com)
GA exerts its physiological effect on altering the Auxin status of tissue. (agrilearner.com)

These substances include 'bone morphogenetic proteins' (BMPs), which play an important role in tissue development. (charite.de)
Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
Launch Graft-versus-host disease (GVHD) continues to be an important problem after allogeneic bone tissue marrow transplantation (BMT). (biopaqc.com)

Our work uncovers important characteristics of the birthplace of endocrine cells, and shows that enlargement of this microenvironment induces generation of more endocrine cells. (cshlpress.com)
With the help of tissue samples, the aggressiveness of the disease can be assessed on the basis of differentiation characteristics of the tissue (Gleason score, ISUP grading, Ki-67). (spitalmaennedorf.ch)
A diagnosis of OT-DSD is based solely on the presence of ovarian and testicular tissue in the gonad and not on the characteristics of the internal and external genitalia, even if ambiguous. (medscape.com)
Apocrine skin carcinoma has characteristics similar to those of cutaneous breast carcinoma metastases when it presents a tubule-lobular, or cordonal differentiation. (bvsalud.org)

Degeneration and hyalinization of the seminiferous tubules with poor germ cell development is frequently observed. (medscape.com)
In all documented biopsied cases, there is a significant decline in germ cell development and an increase in tubular sclerosis by puberty. (medscape.com)
Because we all develop from a single cell following fertilisation, many structures in our bodies start from one of three common precursor tissues (germ layers), which are then acted upon by different genes and enzymes to signal in which direction development, including sex development, will take place. (can-sg.org)

An inflammation of the stomach, however, deactivates this mechanism, enabling cells to grow in an uncontrolled manner. (charite.de)

We searched PubMed, Google Scholar, Elsevier, and UpToDate databases in this review, and focused on the pathogenesis of IR in women with PCOS and the pathophysiology of IR in various tissues. (biomedcentral.com)
Lately, more and more research possess implicated chondrocyte terminal differentiation (hypertrophy-like adjustments) in the pathogenesis of OA. (exposed-skin-care.net)
Because IL-21 augments Th17 cell differentiation, indirect proof for the function of IL-21 in GVHD pathogenesis could be produced from such GVHD research. (biopaqc.com)
Whereas IL-17 and Th17 cells reduce GVHD mediated by CD4+ and CD8+ donor T cells, 11 Th17 cells accelerated GVHD mediated exclusively by CD4+ T cells.12 Naive CD4+ T cells skewed toward a Th17 phenotype in vitro have been used to demonstrate that Th17 cells contribute to GVHD pathogenesis, especially involving the skin and lung. (biopaqc.com)

Build up of cytoplasmic -catenin leads to its translocation towards the nucleus, where it binds to transcription elements such as for example lymphoid enhancing element (LEF)/T cell element (TCF) to create a transcriptionally energetic complicated that focuses on genes such as for example those encoding MYC, cyclin D1, MMP3 and Compact disc44 [17]. (exposed-skin-care.net)

He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. (ubc.ca)
Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)
Both human and animal models of diabetes and obesity were utilized to examine the use of stem cell intervention and gene therapy to amplify HO-1 levels. (nymc.edu)
PHOX2B gene mutations that cause CCHS are believed to interfere with the PHOX2B protein's role in supporting neuron formation and differentiation, especially in the autonomic nervous system. (medlineplus.gov)
This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. (medlineplus.gov)

Together, this forms a signaling gradient that guides stem cell turnover and differentiation, and serves as the basis for the gland's structural stability. (charite.de)

Enlargement of the maxillary sinus It plays an important role in the growth of the body of the maxilla. (glassbox.tv)
In fact, endogenous Fgf18 is known to play an important role in skeletal growth and development because mice lacking Fgf18 exhibit several malformations such as delayed closure of the calvarial sutures, enlargement of the growth plate, and impairment of osteogenic differentiation. (cusabio.com)
Pituitary growth hormone also known as somatotropin is a peptide hormone produced and stored by somatotrophic cells in the pituitary gland of the brain. (nwac-hq.org)
It is the most potent hormone produced in the body and virtually acts on every cell leading to cellular growth, differentiation and reproduction. (nwac-hq.org)
The growth hormone does this through a direct action mediated through growth hormone receptors on target cells and through an indirect action. (nwac-hq.org)
The growth hormone therefore has both direct and indirect actions on muscles but with overall enlargement and strength. (nwac-hq.org)
The growth of the cells is subject to the influence of the male sex hormone testosterone, therefore the medicinal lowering of the hormone can sometimes be part of the therapy. (spitalmaennedorf.ch)
Growth Hormones can also be defined as substances synthesized in particular cells and are transferred to other cells where in extremely small quantities influence development process. (agrilearner.com)
SOS-1 is a guanine nucleotide-exchange factor that functions in the transduction of signals that control cell growth and differentiation 9,10 . (bvsalud.org)

We discovered that 'stromal cells' - a type of cell surrounding the gastric glands - are not only responsible for mechanical stability of the glands, as previously thought. (charite.de)
Various cell lineages such as the epithelial glandular cells and the stromal spindle cells are involved. (ijpmonline.org)

Current knowledge about the identity and function of these stem cell compartments has been largely drawn from a variety of transgenic and spontaneously mutated mouse models that are characterized by rapid rates of aging or have been used to examine regeneration from injury in the context of natural or accelerated aging. (karger.com)
In this review, we will present current data on lung aging and lung regeneration, with specific attention paid to stem cell-driven regeneration within the context of aging. (karger.com)

Pancreatic endocrine cells were known to emerge along pancreatic tubes, but since these tubes are spread throughout the organ, the exact location of endocrine cell emergence was difficult to pinpoint. (cshlpress.com)
In order to minimize the need for animal models, they also developed special organ-like tissue microstructures known as organoids. (charite.de)

Previous research has pinpointed this network as the location where an endocrine progenitor cell (stem cell) arises during development. (cshlpress.com)
Ciliary control of adipocyte progenitor cell fate regulates energy storage. (utah.edu)

While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
She serves on NIH study sections and as reviewer for journals in her area of expertise, manages an active laboratory, supervises students in pulmonary biology and epithelial cell research and has received awards recognizing both teaching and original research accomplishments. (rochester.edu)

The virus localizes in epithelial and endothelial cells at many sites as well as within macrophages and reticuloendothelial cells. (iastate.edu)

He continues: "In fact, our team has now discovered that the infection disrupts complex interactions between different cell types and signals which are responsible for tissue stability. (charite.de)
If fetal tissues were to receive erroneous signals at an early stage, or fail to receive appropriate ones, reproductive development could halt, or attempt to proceed down the opposite sex pathway. (can-sg.org)

This process causes white adipocyte tissue (WAT) expansion and, ultimately, obesity ( 3 ). (diabetesjournals.org)

Our group showed that the generation of pancreatic endocrine cells, including the beta cells responsible for producing insulin in our bodies, is promoted by a specialized microenvironment within the embryonic pancreas. (cshlpress.com)
These cells then could be transplanted back into the patient, and there produce insulin normally. (cshlpress.com)

The work of Neufeld et al from the late 1960s demonstrated that mucopolysaccharide accumulation in fibroblasts from patients with Hurler and Hunter syndromes could be corrected by co-culturing them with fibroblasts or tissue extracts from patients with a different MPS. (medscape.com)

Destruction of their cells results in a marked rhinitis and conjunctivitis. (iastate.edu)

Some cell wall polysaccharide synthesis and cytoskeleton formation-related proteins were up-regulated by JA to promote tuber cell expansion. (biomedcentral.com)

and acquisition of cultures from the affected area by syringe (if abscess), skin punch (if cellulitis only), or deep infected tissue (if surgical debridement). (cdc.gov)
Tissues obtained through subsequent surgical debridements of lung, pleural, diaphragmatic, and subpulmonic abscesses, left lower lobe segmentectomy, and decortication all grew a mold morphologically consistent with A. fumigatus . (cdc.gov)
The pathology laboratory received a 0.3 cm surgical skin sample, which was microscopically described as a dermis fragment infiltrated by neoplasia consisting of small cells, hyperchromatic nuclei, grouped into small nodules, cords or outlining structures ring, dissecting the entire dermis and with preserved epidermis. (bvsalud.org)

The clinical examination noticed a hand tumour involving the palmar and dorsal side with associated homolateral cervical lymph nodes enlargement. (jortho.org)
There were multiple homolateral axillary lymph nodes enlargement, the biggest of 1 .5cm in diameter. (jortho.org)
Two years later neck node enlargement was suspicious for lymph node metastasis during ultrasound examination and conservative neck dissection was performed. (asploro.com)
Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. (rarediseases.org)
Lymphocytes are stored within lymph nodes and may also be found in other lymphatic tissues. (rarediseases.org)

Lung failure due to aging can be traced to loss of lung stem cell regenerative capacity within the distinctive stem cell niches found within each compartment of the lung. (karger.com)

Müllerian duct structures typically develop on the gonadal side not containing testicular tissue. (medscape.com)
Wolffian duct structures tend to be observed on the gonadal side containing functioning testicular tissue. (medscape.com)
8 A highly vascularized stroma, dispersed duct-like structures, and sharp demarcation between poroid cells and surrounding keratinocytes is seen. (clinicaladvisor.com)

Endocrine cells exist in clusters called "islets of Langerhans. (cshlpress.com)
We discovered that these cells depend on the architecture of their microenvironment and that the weblike network of pancreatic tubes serves as a functional microenvironment for the production of endocrine cells. (cshlpress.com)
This alteration revealed that increasing the overall volume of these tubes during pancreatic development resulted in an increased mass of endocrine cells, suggesting that these tubes act as a promoter of endocrine cell development. (cshlpress.com)
Pancreatic endocrine cell development has been a major research subject for many years and it has informed studies aimed at generating replacement beta cells, which are the cells that become nonfunctional in diabetes. (cshlpress.com)
Many key steps of endocrine cell differentiation have been well-characterized, but whether the architecture of the microenvironment containing the progenitors is important for proper endocrine development has remained in question. (cshlpress.com)
Our work shows that developing pancreatic tubes organize into a weblike network (as opposed to a branching tree of tubes found in the mature pancreas) and create a home that promotes endocrine cell generation. (cshlpress.com)
Formation of more of these tubes results in more endocrine cells. (cshlpress.com)
Endocrine cell deficiency leads to diabetes, which can theoretically be cured by providing functional endocrine cells to patients. (cshlpress.com)
Recent advances in stem cell biology have enabled us to make endocrine-like cells in the lab. (cshlpress.com)
These findings suggest that lab-made endocrine cells could be improved by developing these cells in a microenvironment that resembles their birthplace. (cshlpress.com)
This suggestion is supported by a recent boost in endocrine cell generation when the cells were grown in a 3-dimensional matrix, demonstrating that tissue conformation is influential to proper endocrine expansion and differentiation. (cshlpress.com)
For decades, researchers in the pancreas development and diabetes fields have been trying to understand how endocrine cells are made. (cshlpress.com)

Cells are grouped in homogenous tracts arranged in nodules. (jortho.org)

Plant cells behave qualitatively similar to biological tissue. (uni-stuttgart.de)
Biological tissue behaves capacitively in an alternating electric field and exhibits frequency-dependent changes. (uni-stuttgart.de)

Rhabdomyosarcoma is the most common lesion of striated muscle cell origin arising in the head and neck region. (radiologykey.com)

Anatomy30

Organisms4

Diseases2

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes34

Disciplines and Occupations1

Information Science3

Proliferation9

Adipose tissue21

Adipocyte differentiation1

Connective tissue5

Vascular7

Tumors3

Sexual differentiation4

Hematopoietic stem2

Maturation3

Cartilage3

Intracellular6

Necrosis4

Secretion3

Pathways3

Organs5

Benign4

Metastatic2

Neural3

Auxins2

Fibrotic2

Apoptosis1

Immunohistochemical1

Soft-tissue10

Cytoplasm1

Hyperplasia3

Membrane4

Stem cells10

Mucinous1

Xylem2

Malignant3

Chondrocytes2

Adipocytes1

Protein1

Induce1

Physiological2

Bone3

Characteristics4

Germ3

Inflammation1

Pathogenesis4

Genes1

Gene5

Turnover1

Growth9

Stromal2

Regeneration2

Organ2

Progenitor cell2

Epithelial cell2

Endothelial cells1

Signals2

Obesity1

Insulin2

Fibroblasts1

Destruction1

Synthesis1

Surgical3

Lymph5

Regenerative1

Structures3

Endocrine12

Homogenous1

Biological2

Lesion1