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  • Developmental
  • 1996 ) Developmental control of cell cycle regulators: a fly's perspective. (biologists.org)
  • Minutes are a class of dominant mutants that are characterized by their recessive lethality, increased developmental time, smaller body with short fine bristles in the heterozygotes and with varying degrees of reduced survival and fertility (Lindsley et al. (springer.com)
  • These studies have demonstrated that they play critical roles in regulating the signaling activities of Wnt, Hh, TGF-β and To whom correspondence should be addressed: Xinhua Lin, PhD, Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet avenue, Cincinnati, OH 45229, USA. (sciencedocbox.com)
  • Much of the research in the Pringle laboratory exploits the power of yeast as an experimentally tractable model eukaryote to investigate fundamental problems in cell and developmental biology such as the mechanisms of cell polarization and cytokinesis. (stanford.edu)
  • Organisms, tissues and cells are genetically programmed to grow to a specific largely pre-set size and shape within the appropriate developmental timing. (biomedcentral.com)
  • The cell cycle machinery responds to external signals such as hormones, sucrose, and light, which are integrated with developmental, positional, and epigenetic signals. (plantcell.org)
  • defective
  • The isolation of non-cell-autonomous larval growth-defective mutants suggests that specialized organs coordinate growth throughout the animal and provides new tools for studies of organismal growth regulation. (biologists.org)
  • RIC-8 was discovered during a genetic screen of Caenorhabditis elegans that was designed to uncover mutants with defective neurotransmitter release ( 3 ). (sciencemag.org)
  • Animal cells achieve asymmetrical divisions by translating polarizing cues into an asymmetric distribution of polarity regulators like the partitioning defective complex ( Gönczy, 2008 ). (plantcell.org)
  • 1997
  • 1997 ) Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila . (biologists.org)
  • cytokinesis
  • Cytokinesis is the postmitotic event that physically separates the cytoplasms of the daughter cells. (rupress.org)
  • In both fungal and animal cells, cytokinesis is performed in two steps, cleavage-furrow formation and abscission. (rupress.org)
  • Complementation assays showed that the Arabidopsis α group Aurora kinases are functionally divergent from the single β group member AUR3 and that AUR1 functions in division plane orientation prior to cytokinesis. (plantcell.org)
  • 2015) . Exocyst-dependent membrane addition is required for anaphase cell elongation and cytokinesis in Drosophila . (sdbonline.org)
  • Additionally, it was observed that the increase in cell surface area in wild type peaks a few minutes into cytokinesis, and that onr and fun mutant cells have a greatly reduced rate of surface area growth specifically during cell division. (sdbonline.org)
  • homozygous
  • Somatic clones of the eyes, consisting of homozygous tissue in otherwise heterozygous organisms that develop within a standard timeframe, signify that more severe phenotypes are masked by an extension in the time of development of homozygous mutants. (biomedcentral.com)
  • centrosomes
  • Asymmetric stem cell division is often accompanied by stereotypical inheritance of the mother and daughter centrosomes. (elifesciences.org)
  • Plk1 is found in several locations throughout most of the cell cycle and its main functions start in G2, during which it localizes to centrosomes. (eu.org)
  • Moreover, the centrosomes of mutant primary spermatocytes do not migrate from the cell cortex to the nuclear envelope, establishing a new role for NudE. (biologists.org)
  • organisms
  • Thus, organs and organisms grow until they reach their characteristic size and shape and then they stop - they can even compensate for experimental manipulations that change, over several fold, cell number or average cell size. (biologists.org)
  • The cell is the basic structural unit of all living organisms. (biomedcentral.com)
  • In developing organisms, divergence from the canonical cell division cycle is often necessary to ensure the proper growth, differentiation, and physiological function of a variety of tissues. (sdbonline.org)
  • Molecular
  • Although many tools are available to facilitate genetic, molecular biological, biochemical, and cell biological studies in Chlamydomonas, expression of unselected transgenes of interest (GOIs) has been challenging. (stanford.edu)
  • The title "Cross-Talk between Cell Division Cycle and Development in Plants" was chosen for a workshop hosted by the Instituto Juan March de Estudios e Investigaciones in Madrid (Spain) from November 12 to 14, 2001, and cosponsored by the Institute of Molecular Agrobiology, Singapore, to address the age-old question of whether cells make plants or plants make cells. (plantcell.org)
  • mechanisms
  • Despite recent progress in understanding growth control within the cell unit, the mechanisms that coordinate growth at the organismal level are still poorly understood. (biologists.org)
  • Our results indicate that larval growth and endoreplication are coupled processes that, although linked to cell cycle control mechanisms, are regulated by dMyc and dMnt. (biologists.org)
  • However, mechanisms underlying switches in division plane orientation remain elusive. (plantcell.org)
  • mechanisms driving formative division plane establishment in plant cells remain elusive. (plantcell.org)
  • Even slight disruption of this homeostasis can lead to disease, thus it is critical to understand the complex mechanisms that control cell growth. (biomedcentral.com)
  • ribonucleoprotein
  • This study shows that SmD1 , a core component of the Drosophila small nuclear ribonucleoprotein particle (snRNP) implicated in splicing, is required for miRNA biogenesis and function. (sdbonline.org)
  • Greider and Blackburn, "The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity," Cell 51:887-898 (1987). (freepatentsonline.com)
  • hedgehog
  • We have also shown that HEDGEHOG‐GLI (HH‐GLI) signalling is required for GBM growth, stem cell expansion and the expression of this (ES)‐like stemness signature. (embopress.org)
  • spindles
  • We find NudE on kinetochores, spindles and the nuclear envelope at various stages in the cell cycle or in various cell types. (biologists.org)
  • discs
  • Drosophila imaginal discs originate as small invaginations of the embryonic ectoderm and proliferate to form epithelial sacs that differentiate adult cuticular structures during pupal metamorphosis ( Cohen, 1993 ). (biologists.org)
  • We found that induction of h14-3-3 gamma resulted in the abnormal appearance of replicating cells in the differentiating proneural photoreceptor cells of eye imaginal discs where h14-3-3 gamma was driven by the heat shock promoter. (biomedcentral.com)
  • Similarly, we found that driving h14-3-3 gamma expression specifically in developing eye discs with the GMR-Gal4 driver resulted in increased numbers of replicative cells following the morphogenetic furrow. (biomedcentral.com)
  • nuclear
  • Overexpression of dMyc in endoreplicating cells results in dramatic increases in nuclear DNA content and cell and nucleolar size, whereas dMnt overexpression has the opposite effect. (biologists.org)
  • pathway
  • In this review, we discuss the recent findings on how the Greatwall-Endosulfine pathway may provide a connection between cell growth and the cell cycle machinery. (mdpi.com)
  • cycle
  • These cells then differentiate as photoreceptors and themselves express hh , allowing the cycle to propagate toward the anterior of the disc. (biologists.org)
  • The dynamic localization of Plk1 to various subcellular structures during successive stages of cell cycle is mainly attributed to its PBD-dependent interaction with specific phosphoepitopes present in different subcellular locations. (eu.org)
  • Aurora kinases participate in multiple processes during the mammalian cell cycle ( Carmena and Earnshaw, 2003 ). (biologists.org)
  • Conversely, overexpression of Mad family members leads to arrest of the cell cycle in G1 (reviewed by Zhou and Hurlin, 2001 ). (biologists.org)
  • The cell cycle is widely known to be regulated by networks of phosphorylation and ubiquitin-directed proteolysis. (rupress.org)
  • The mainstream ideas that emerged indicated that the activity of key cell cycle regulators (controlling cell cycle transitions) also can have profound effects on development. (plantcell.org)
  • The major checkpoints of the cell cycle are the G1/S and G2/M transitions. (plantcell.org)
  • The arrows represent the complex interconnections not only between the core of the cell cycle machinery and the different stimuli but also between expansion and differentiation or expansion and development. (plantcell.org)