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  • cancer
  • The results of the present study demonstrated that 20/26 HUB genes were associated with the metabolic processes that control human circadian rhythms, which supports the hypothesis that a number of cancer types are dependent from circadian cycles. (spandidos-publications.com)
  • Prior studies have demonstrated the association between circadian rhythm alterations and the development of breast ( 15 ) and prostate cancer ( 16 ), B-cell lymphoma ( 17 ), non-small cell lung ( 18 ), testicular ( 19 ) and ovarian cancer ( 20 ). (spandidos-publications.com)
  • Previous studies have demonstrated that liver cancer initiation may be due to alterations in circadian rhythmic genes, including PER3 ( 23 ) and CRY genes, and casein kinases ( 24 ). (spandidos-publications.com)
  • Furthermore, the presence of hepatitis viral infection, which is a cause of liver cancer, has been revealed to cause dysregulation of the expression of circadian genes ( 26 ). (spandidos-publications.com)
  • However, the status of MAD1L1 expression in small-cell lung cancer (SCLC) remains unknown. (cancerindex.org)
  • This fact is supported by the finding that most HPV-positive cancer cells maintain the expression of E6 and E7 ( 4 , 52 ). (asm.org)
  • Studies of the viral life cycle are important for understanding the process of HPV-induced cancer formation. (asm.org)
  • DelSal G, Loda M and Pagano M (1996) Cell cycle and cancer: critical events at the G1 restriction point. (els.net)
  • This research is important because it identifies genes that may be important in this rare cancer," said Dr. Linghua Wang , assistant professor of molecular and human genetics at Baylor and lead author of the study. (bcm.edu)
  • There is an increasing understanding that the interrelationship between BRCA gene cluster and Fanconi anemia (FA), mismatch repair (MMR) and DNA repair gene status plays a key role in the pathogenesis of cancer predisposition syndromes. (spandidos-publications.com)
  • We aimed to assess whether CHEK2 was subject to DAE in lymphoblastoid cell lines (LCLs) from high-risk breast cancer patients for whom no mutation in BRCA1 or BRCA2 had been identified. (biomedcentral.com)
  • As part of an international breast cancer genetics study aiming to investigate candidate genes conferring an intermediate-risk of breast cancer, we mutation screened the coding exons and the adjacent proximal introns of CHEK2 in 1415 cases and 1204 controls. (biomedcentral.com)
  • The normal forms of these genes are called proto-oncogenes, while the mutated, cancer-causing forms are called oncogenes. (studymode.com)
  • Therefore, only one copy of the gene needs to be mutated in order to promote cancer. (studymode.com)
  • Overall, the present study identified multiple key genes in UCEC and clinically relevant small molecule agents, thereby improving our understanding of UCEC and expanding perspectives on targeted therapy for this type of cancer. (spandidos-publications.com)
  • Stages Cancer is a term for disease in which abnormal cell division without control and invade the near by tissue What goes wrong in the cell cycle a. (coursehero.com)
  • Dead cells remain and form a growth known as a tumor Metastasize: The spread of cancer to the new part of the bod. (coursehero.com)
  • Biclustering identified tightly co-expressed gene sets in the tumours of restricted subgroups of breast cancer patients. (biomedcentral.com)
  • The co-expressed genes in these biclusters were significantly enriched for particular biological annotations and gene regulatory modules associated with breast cancer biology. (biomedcentral.com)
  • 16. The method of claim 13 or 14, wherein said cell proliferative disorder is cancer. (patentsencyclopedia.com)
  • viral
  • In our previous study, a network analysis was performed on dysregulated genes in HepG2 cells, a hepatoblastoma cell line that lacks the viral infection, compared with normal hepatocytes, identifying the presence of 26 HUB genes. (spandidos-publications.com)
  • The cell type-dependent different EBV latent gene expression patterns appear to be determined by the cellular epigenetic machinery and similarly viral oncoproteins recruit epigenetic regulators in order to deregulate the cellular gene expression profile resulting in several human cancers. (mdpi.com)
  • However, it is likely that additional viral genes also contribute to the establishment of hyperproliferative potentially precancerous lesions caused by high-risk HPVs. (asm.org)
  • This tight association between viral replication and the host cell differentiation program is a prominent feature of the HPV life cycle. (asm.org)
  • The E4 open reading frame is located in the region of early viral genes, such as E1 and E2, even though other studies have suggested that its expression pattern is more characteristic of a late gene. (asm.org)
  • Regulation
  • Following the initial observation of DNA methylation as one of the most critical aspects for the stable maintenance of gene expression pattern, today epigenetic regulation has earned a notable place in scientific research on cellular and physiological response mechanism towards multiple external stimuli, particularly in disease biology. (mdpi.com)
  • Cole MD and McMahon SB (1999) The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation. (els.net)
  • Alteration in gene expression regulation provides a potential mechanism for generating disease susceptibility. (biomedcentral.com)
  • Interestingly, up-regulation of mitotic checkpoint components is as common, and in some cases more common, than down-regulation ( 1 ). (pnas.org)
  • malignant
  • We also compared the gene expression profile (no RA treatment) between non-malignant melan-a mouse melanocytes and B16 melanoma cells. (biomedcentral.com)
  • When the scientists analyzed two T-cell receptors (Vβ and Vα) and how they are expressed, they found that they were rearranged when the malignant T-cell clone expanded in one-third of patients. (bcm.edu)
  • epithelial
  • By contrast, we report here that loss of CARM1 results in hyperproliferation of pulmonary epithelial cells during embryonic development. (biologists.org)
  • Human papillomaviruses (HPVs) infect epithelial cells, causing hyperproliferative lesions such as warts and condylomas. (asm.org)
  • MAD1
  • Overexpression of Mad1 causes aneuploidy and chromosomal instability through weakening mitotic checkpoint signaling caused by mislocalization of the Mad1 binding partner Mad2. (pnas.org)
  • Cells overexpressing Mad1 are resistant to microtubule poisons, including currently used chemotherapeutic agents. (pnas.org)
  • Reduction of individual components of the mitotic checkpoint, including Mad1, Mad2, Bub1, BubR1, Bub3, CENP-E, and Mps1, leads to aneuploidy and CIN in multiple systems ( 7 ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ - 20 ). (pnas.org)
  • processes
  • Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. (nih.gov)
  • circadian
  • The present study aimed to identify whether these previously identified HUB genes participate in the network that controls the human circadian rhythms. (spandidos-publications.com)
  • Finally, the results of the present study identified the microRNAs involved in the network formed by the overlapping of HepG2 and circadian genes. (spandidos-publications.com)
  • Circadian rhythms control the 24 h cycle of specific metabolic functions required by living beings, ensuring an efficient metabolic homeostasis ( 1 , 2 ). (spandidos-publications.com)
  • The molecular clock of transcription involves a translational feedback mechanism of genes, including clock circadian regulator (CLOCK), period circadian clock (PER), aryl hydrocarbon receptor nuclear translocator like (BMAL1) and cryptochrome circadian clock (CRY), able to regulate a number of physiological properties, including body temperature, melatonin secretion, hormone secretion, blood pressure and the sleep-wake cycle ( 3 ). (spandidos-publications.com)
  • The circadian clock mechanism involves transcription-translation feedback loops comprised of a set of core clock genes. (nih.gov)
  • In mammals, the circadian clock is composed of a primary negative feedback loop involving the genes, Clock/Npas2, Bmal1, Period1 (Per1), Per2, Cryptochrome1 (Cry1) and Cry2 . (nih.gov)
  • cancers
  • We reasoned that biclustering may be able to identify clinically-significant gene expression modules that stratify breast cancers according to inter-tumour heterogeneity. (biomedcentral.com)
  • However, extensive analysis has revealed that mitotic checkpoint genes are only rarely mutated in human cancers. (pnas.org)
  • clinically relevant
  • Many of these studies use clustering techniques [ 18 - 23 ] to group tumours with similar gene expression patterns, and thus to identify clinically relevant molecular biomarkers for tumour classification. (biomedcentral.com)
  • tumour
  • Many studies have revealed correlations between breast tumour phenotypes, variations in gene expression, and patient survival outcomes. (biomedcentral.com)
  • To overcome this limitation, biclustering algorithms group genes and tumour samples simultaneously, to identify subsets of genes with similar expression patterns over subsets of tumour samples. (biomedcentral.com)
  • mutation
  • 13. A method of identifying a subject at risk for developing a cell proliferative disease, comprising detecting a mutation in the 3' untranslated region (UTR) of RAS in a patient sample wherein the presence of a mutation indicates greater risk of developing a cell proliferative disease. (patentsencyclopedia.com)
  • alteration
  • This review elucidates the epigenetic consequences of EBV-host interactions during development of multiple EBV-induced B-cell lymphomas, which may lead to the discovery of novel therapeutic interventions against EBV-associated B-cell lymphomas by alteration of reversible patho-epigenetic markings. (mdpi.com)
  • cyclins
  • The B-type cyclins remain active throughout M-phase, but their activity immediately ceases once cell division is complete and the two daughter cells once again enter G1. (studymode.com)
  • melanoma
  • In an analysis of sequential global gene expression changes during a 4-48 h RA treatment of B16 mouse melanoma cells, we found that RA increased the expression of 757 genes and decreased the expression of 737 genes. (biomedcentral.com)
  • tightly
  • These events are tightly regulated and certain checkpoints must be passed in order for the cell cycle to be completed. (antibodies-online.com)
  • Tightly associated with it, Grk will be secreted to the adjacent follicle cells (gray grid), which will acquire a dorsal fate and later synthesize the dorsal appendages of the chorion (not shown). (genetics.org)