Cell division cycle arrest the cell cycle. Medical search. Frequent questions

In mouse embryonic stem cells (ESCs), Cdc7 is needed for proliferation. (wikipedia.org)
JAM3 knockdown additionally inhibited trophoblast proliferation and increased the number of trophoblasts in the sub-G1 and G2/M phases, indicating cell-cycle disturbance and apoptosis. (bioone.org)
Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells. (nih.gov)
These results bear on the control of cell proliferation. (ebi.ac.uk)
Thus, unlike other tumor suppressors, RPL5/RPL11 play an essential role in normal cell proliferation, a function cells have evolved to rely on in lieu of a cell cycle checkpoint. (nih.gov)
A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
1] 'Multiforme,' which refers to a heterogenous histologic appearance and proliferation of multiple cell types, was abandoned from the revised nomenclature in the 2007 World Health Organization Classification of Tumors of the Central Nervous System, and is now simply called 'glioblastoma. (cancernetwork.com)
2] Glioblastoma is histologically defined by neoplastic cells with astrocytic characteristics and the presence of either endothelial proliferation-often in a glomeruloid morphology-and/or necrosis, which may resemble a pseudopalisading pattern (a false fence of neoplastic cells surrounding an area of necrotic tissue). (cancernetwork.com)
During the natural developmental process of Drosophila, the developing eye shows a remarkable, tight coordination between cell proliferation and the steps for cell specialisation. (europa.eu)
Cell proliferation includes a series of events that is tightly regulated by several checkpoints and layers of control mechanisms. (frontiersin.org)
In conclusion, we provide useful experimental approaches and bioinformatics to identify informative and predictive genes at the single-cell level, which opens up new means to describe and understand cell proliferation and subpopulation dynamics. (frontiersin.org)
However, most of our knowledge about cell proliferation comes from studies that average data from large and mixed cell populations. (frontiersin.org)
One factor supposed to be involved in self-renewal is the rapid proliferation rate of ES cells, which is coupled to an unusual cell cycle distribution with the majority of cells in S-phase and a very short G1-phase. (uni-muenchen.de)
Generally, cells have to closely coordinate growth and cell cycle progression during proliferation to prevent premature division. (uni-muenchen.de)
Moreover, a putative crosstalk between ribosome biogenesis and proliferation of ES cells was assessed. (uni-muenchen.de)
Further, impaired proliferation of ES cells was observed. (uni-muenchen.de)
Thus, the PeBoW-complex seems to be an essential factor for the rapid proliferation of ES cells and might therefore also be involved in self-renewal. (uni-muenchen.de)
Overall, the results suggest that ES cells use different mechanisms as mature cells to coordinate their proliferation rate with ribosome biogenesis. (uni-muenchen.de)
During cell growth and proliferation, ubiquitin plays an outsized role in promoting progression through the cell cycle. (intechopen.com)
Notably, the G1/S boundary represents a major barrier to cell proliferation and is universally dysfunctional in cancer cells, allowing for the unbridled proliferation observed in malignancy. (intechopen.com)
Numerous E3 ubiquitin ligases, which facilitate the ubiquitination of specific substrates, have been shown to control G1/S. In this chapter, we will discuss components in the ubiquitin proteasome system that are implicated in G1/S control, how these enzymes are interconnected, gaps in our current knowledge, and the potential role of these pathways in the cancer cycle and disease proliferation. (intechopen.com)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-test was used to observe the proliferation of human breast cancer MCF-7 and MDA-MB-231 cells induced on VALD-3. (researchsquare.com)
Fenbendazole may prevent carcinogenesis by reducing the proliferation of normal and cancer cells, decreasing the formation of related cancer oncogenes, and blocking the binding of cancer promoters to DNA.Fenbendazole is a safe and effective anticancer drug that has the ability to reduce cancer cells in humans. (fenbenmed.com)
Among the proteins identified was Yph1p, a homologue of zebrafish pescadillo, mutations in which lead to cell proliferation defects. (rupress.org)
Results and Conclusions: The adaptation process was characterized by initial cell population growth arrest, and after that extensive cell death, followed by proliferation and long-term survival of clonal cultures. (lu.se)
Proliferation and cell cycle progression of the serum-free cultures closely mimicked that of serum-dependent cells. (lu.se)

For the developer, cell differentiation is the key to cancer therapy. (cancer.gov)
Antineoplastons are the surveillance system that directs cancer cells into normal channels of differentiation . (cancer.gov)
The notion of controlling tumor growth through a naturally occurring biochemical mechanism in the body that directs cancer cells into normal channels of differentiation is one of the theoretical foundations of antineoplaston therapy. (cancer.gov)
The proposed components in the body that correct the differentiation problems of abnormal cells and send them into normal pathways have been given the name "antineoplastons" by the developer. (cancer.gov)
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. (cancerindex.org)
The hallmark of embryonic stem (ES) cells is their ability for self-renewal (capability of unlimited cell division without the loss of pluripotency) as well as for differentiation into all cell types of the adult organism. (uni-muenchen.de)
A high expression of Pes1, Bop1 and WDR12 was observed in ES cells, which strongly decreased during in vitro differentiation. (uni-muenchen.de)
A major limitation in approaching this problem has been the lack of suitable cell lines that exhibit normal, terminal, and synchronous differentiation in the absence of endogenous oncoproteins and in response to physiologic cytokines, and whose differentiation can be arrested by ectopically expressed human oncoproteins. (nih.gov)
Differentiation was normal and terminal as evidenced by morphology, cell surface markers, gene expression, and functional assays. (nih.gov)
The differentiation of the cells could be arrested by heterologous oncoproteins including AML1/ETO, PML/RARalpha, PLZF/RARalpha, Nup98/HoxA9, and other Hox proteins. (nih.gov)
These myeloid cell lines provide tools for examining the biochemical and genetic pathways that accompany normal differentiation as well as a system in which to dissect how other leukemic oncoproteins interfere with these pathways. (nih.gov)
[1] is the differentiation of the ovum (egg cell) into a cell competent to further develop when fertilized. (wikipedia.org)
Here we suggest that obligate multicellular organisms adopt a very similar strategy, in which reproductive cells actively induce cell-cycle arrest and differentiation by cells dedicated to safety against the environment. (groundwater-2011.net)
Therefore, gene activity is an important mechanism in embryonic development and adult stem cell differentiation. (edu.au)

It has been suggested that the protein is essential for initiation of DNA replication and that it plays a role in regulating cell cycle progression. (wikipedia.org)

This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer. (researchsquare.com)
Most changes were subtle, but frequently the genes with altered expression were involved in basal cellular functions such as cell division, cell cycle regulation, apoptosis and cell signalling. (lu.se)

Through this process, a single mother cell divides to generate two genetically identical daughter cells. (europa.eu)
The diverse cell types are genetically identical, but differ in their form and function due to differences in gene expression. (edu.au)
During this phase the cell copies its DNA in preparation for mitosis, when they divide to produce cells genetically identical to themselves. (concordia.ca)

Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. (kegg.jp)
Studies suggest that some ribosomal proteins may have other functions, such as participating in chemical signaling pathways within the cell, regulating cell division, and controlling the self-destruction of cells (apoptosis). (medlineplus.gov)

It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
Preclinical evidence supports synergistic anti-tumor effects when downstream RAS/MAPK pathway inhibition is combined with cell cycle inhibition in CRC and PDAC," he said. (pharmalive.com)
This inhibition is intended to result in prolonged cell cycle arrest, ultimately leading to cell death, or apoptosis. (pharmamanufacturing.com)
Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. (lsbio.com)
The mechanism of vincristine is the inhibition of microtubule dynamics that would cause mitotic arrest and eventual cell death. (smpdb.ca)

Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway. (nih.gov)
VALD-3 also regulated the Wnt/β-catenin signaling pathway in breast cancer cells, inhibiting the activation of downstream molecules. (researchsquare.com)

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and accounts for approximately 60% to 70% of all renal tumors [ 1 ]. (hindawi.com)
This drug is also used to treat alveolar hydatid disease, cystic Echinococcosis, uterine papillary carcinoma, liver metastasis from colorectal or pancreatic carcinoma, and other tumors that are resistant to chemotherapy.Fenbendazole helps to reduce breast cancer cells, so you should take this before surgery. (fenbenmed.com)
This scheme is straightforward and essentially divides the vasoformative tumors into 2 broad groups: hemangiomas and vascular malformations (see Table 1 below). (medscape.com)

Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. (kegg.jp)

Nuclear division e. karyokinesis occurs in 4 phases - prophase, metaphase, anaphase and telophase. (studyinnovations.com)
Progression from metaphase to anaphase is blocked and cells enter a state of mitotic arrest. (smpdb.ca)
The bright cell with lots of orange on the right is in metaphase and the cell with lots of green on the left is in anaphase. (concordia.ca)
The drug we are developing stops cancer cells from continuing to divide and arrests cells in metaphase. (concordia.ca)

During this work, the function of the proteins Pes1, Bop1 and WDR12, which were shown previously to be involved in ribosome biogenesis of mature cell lines, was investigated in mouse ES cells. (uni-muenchen.de)
Yph1p was also found in complex with a variety of other proteins, including those involved in ribosome biogenesis, cell cycle regulation, and checkpoint control. (rupress.org)

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. (wikipedia.org)
The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. (wikipedia.org)
this means that most eukaryotic cells have the Cdc7 kinase protein. (wikipedia.org)
The product encoded by this gene is predominantly localized in the nucleus and is a cell division cycle protein with kinase activity. (wikipedia.org)
Although expression levels of the protein appear to be constant throughout the cell cycle, the protein kinase activity appears to increase during S phase. (wikipedia.org)
The gene, CDC7, is involved in the regulation of cell cycle because of the gene product Cdc7 kinase. (wikipedia.org)
Cell-cycle arrest was associated with the engagement of checkpoint kinase 2-cell division cycle 25C-cyclin-dependent kinase 1/cyclin B1 signaling. (bioone.org)
Oscillations occur when the balance of kinase and phosphatase rates in each cycle is in a range bounded by two critical values. (ebi.ac.uk)
This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
Volasertib is an investigational inhibitor of polo-like kinase, an enzyme in the Plk family that regulates cell division. (pharmamanufacturing.com)
Primary mouse embryo fibroblasts lacking Cip1 and Kip1 genes encoding inhibitors of cyclin-dependent kinase-2 were used to further explore the effects of oncogenic Ras on arrest of the cell division cycle. (ku.dk)
Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. (lsbio.com)
The p21 protein binds and inactivates a cell division kinase which results in cell cycle arrest. (giladhirschberger.com)
The drug blocks an enzyme called tyrosine kinase, which is essential to the survival of cancer cells. (fenbenmed.com)

As loss of RPL5/RPL11 abrogates ribosome biogenesis and protein synthesis to the same extent as loss of other essential 60S RPs, we reasoned the loss of RPL5 and RPL11 would induce a p53-independent cell cycle checkpoint. (nih.gov)
Unexpectedly, we found that their depletion in primary human lung fibroblasts failed to induce cell cycle arrest but strongly suppressed cell cycle progression. (nih.gov)
Although early passage primary fibroblast strains that lack both p21(Cip1) and p27(Kip1) fail to assemble cyclin D-dependent kinases, oncogenic Ras retained its ability to induce p19(ARF), but not p16(INK4a), protecting Cip/Kip-null cells from proliferating and undergoing transformation. (ku.dk)
Under these conditions, Ras did not induce G(1) phase arrest but instead triggered DNA synthesis, abnormal nuclear divisions, failure of cytokinesis, and emergence of polyploid cells. (ku.dk)

We consider a minimal cascade model previously proposed for the mitotic oscillator driving the embryonic cell division cycle. (ebi.ac.uk)
We are currently investigating the function of chromatin modifiers during embryonic development, in adult stem cell populations and in cancer, and modelling chromatin-based intellectual disability to discover ameliorating treatments. (edu.au)

8 Astrocytes interact with blood vessels, pericytes, and epithelial cells to organize CNS flow and modulate the blood-brain barrier (BBB). (news-medical.net)
Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotube s elicit genotoxicity in human lung epithelial cells. (cdc.gov)
Our aim was to measure the genotoxicity of MWCNT-7 compared to these two physicochemically-altered MWCNTs in human lung epithelial cells (BEAS-2B & SAEC). (cdc.gov)

The majority of cell cycle regulators, including APC/C, as well as the genes regulating cells' responses to external cues, are very similar between Drosophila and mammals, although the genetic circuit in Drosophila is relatively simple and less complex compared to mammals. (europa.eu)
Here, we used quantitative real-time PCR, profiling the expression of 93 genes in single-cells from three different cell lines. (frontiersin.org)
We found that the total transcript level per cell and the expression of most individual genes correlated with progression through the cell cycle, but not with cell size. (frontiersin.org)
Detailed analysis of cell cycle predictive genes allowed us to define subpopulations with distinct gene expression profiles and to calculate a cell cycle index that illustrates the transition of cells between cell cycle phases. (frontiersin.org)
Here, we employed single-cell gene expression profiling to describe the dynamic transition between cell proliferative states in three different cell lines using a panel consisting of 93 marker genes. (frontiersin.org)
Therefore, in the absence of p16(INK4a), p21(Cip1), and p27(Kip1), oncogenic Ras affects the functions of genes required for completion of the cell cycle. (ku.dk)
Genes are segments of deoxyribonucleic acid (DNA) that contain the code for a specific protein that functions in one or more types of cells in the body. (easierwithpractice.com)
Chromosomes are structures within cells that contain a person's genes. (easierwithpractice.com)
Genes are contained in chromosomes, which are in the cell nucleus. (easierwithpractice.com)
Type I genes tend to be involved in immune response or sensory receptors while type III genes are involved in cell to cell signalling and type II genes are a complex mix of all three types. (easierwithpractice.com)
Mutations in genes can cause cancer by accelerating cell division rates or inhibiting normal controls on the system, such as cell cycle arrest or programmed cell death. (easierwithpractice.com)
Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. (lsbio.com)
Transcriptional activity is regulated by DNA binding transcription factors, but these typically act in more than one cell lineage activating different subsets of target genes in each. (edu.au)
Some alterations were restored when the cells were transferred back to serum-containing medium, indicating that expression of these genes was controlled by components in serum. (lu.se)

This is linked to the lack of a functional G1/S-phase checkpoint, which allows the cells to enter the S-phase almost directly after mitosis. (uni-muenchen.de)
In mature cells, disruptions in ribosome biogenesis are directly linked to the cell cycle machinery by a p53-dependent activation of the G1/S-phase checkpoint, leading to an arrest of cells in G1-phase. (uni-muenchen.de)
Impaired ribosome biogenesis is known to activate a p53-dependent checkpoint in mature cell lines, which leads to an arrest of cells in G1-phase. (uni-muenchen.de)
Treatment of mouse NIH3T3 cells with 5FU, a potent inhibitor of rRNA maturation, confirmed an activation of this checkpoint, leading to weak induction of the tumor suppressor p53, induction of the Cdk-inhibitor p21, an increase in active, hypo-phosphorylated Rb, and to accumulation of cells in the G1- and S-phase with an increase of cells in G1-phase. (uni-muenchen.de)
Hence, ribosomal stress does not lead to checkpoint activation via the p53-p21-Rb pathway in ES cells. (uni-muenchen.de)

Asymmetric cell divisions, in which cellular components, such as existing adherens junctions, are distributed unequally to daughter cells can result in one daughter cell leaving the epithelium. (elifesciences.org)
In contrast, symmetric divisions in epithelia divide cellular components equally, and usually results in both daughter cells remaining in the tissue. (elifesciences.org)
When their function is blocked, the cellular cycle that is required for a cell to divide and multiply is arrested, causing the cell to die. (lymphomainfo.net)
The Incucyte ® Live-Cell Analysis System delivers flexible kinetic quantification of biological phenotypes to monitor growth, motility, morphology, and cellular function. (news-medical.net)
the adaptive nature of individual cellular aging/death programs can only be appreciated when these cellular programs are interpreted within the context of functioning of the whole community of cells. (atlasofscience.org)

Depletion of TMED3 arrested the development of MM in vitro and in vivo. (bvsalud.org)
This was done in vitro as well as in vivo by establishing a xenograft model from a Kir6.2/SUR2 positive high grade serous ovarian cancer cell line. (survivornet.com)
Rat primary astrocytes were isolated from different brain regions (cortex, cerebellum, and hippocampus) and grown in vitro to demonstrate the utilization of live-cell analysis for monitoring and comparing the diversity of cultured astroglia phenotypes. (news-medical.net)
Objective: Serum is usually added to growth media when mammalian cells are cultured in vitro to supply the cells with growth factors, hormones, nutrients and trace elements. (lu.se)
Because in vitro genotoxicity is correlated with in vivo genotoxic response, these studies in primary human lung cells may predict the genotoxic potency in exposed human populations. (cdc.gov)

What this means is that Velcade inhibits-or blocks-the function of a set of proteins inside the cell, specifically a protein group known as the 26S proteasome. (lymphomainfo.net)
One of the critical factors for the control of the protein levels during the cell cycle is the Anaphase Promoting Complex/Cyclosome (APC/C). This complex recognises proteins with specific signatures (or degrons) and targets them for degradation via the protein destruction machinery called the proteasome. (europa.eu)
Localization of the proteins was predominantly nucleolar and the formation of a stable complex (PeBoW-complex), including all three proteins, was experimentally validated in mature mouse cells as well as in mouse ES cells. (uni-muenchen.de)
Initially the arrest is due to lack of sufficient cell cycle proteins to allow meiotic progression. (wikipedia.org)
However, as the oocyte grows, these proteins are synthesized, and meiotic arrest becomes dependent on cyclic AMP . (wikipedia.org)
[7] The cells that comprise the follicle, known as granulosa cells, are connected to each other by proteins known as gap junctions, that allow small molecules to pass between the cells. (wikipedia.org)
The expression of pro-apoptotic proteins and anti-apoptotic proteins in MCF-7 and MDA-MB-231 cells was investigated by Western blotting. (researchsquare.com)
Cancer cells also make too many proteins called proteases that destroy DNA. (fenbenmed.com)

Progression through the cell cycle is driven by the oscillating activity of Cyclin Dependent Kinases (CDKs). (intechopen.com)

In unicellular organisms, cell division is the means of reproduction by which the mother cell produces two or more new cells. (studyinnovations.com)

In this study, we investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms. (researchsquare.com)
Increased intracellular calcium disrupts mechanisms of cell division by arresting the cell cycle in G2/M phase and this is associated with alteration of the oxidative state, disruption of the mitochondria and activation of the caspase-3-independent cell death pathway. (survivornet.com)

lt;div class="textblock">Oncogenic Ras induces two products of the INK4a/ARF tumor suppressor locus (p16(INK4a) and p19(ARF)) in primary human and rodent fibroblasts, ultimately leading to a permanent state of cell cycle arrest resembling replicative senescence. (ku.dk)

Junctional adhesion molecule 3 (JAM3) is involved in epithelial cell junction, cell polarity, and motility. (bioone.org)
On the contrary, elevating CDCA8 augmented cell viability and motility and even reversed the inhibitory effects of TMED3 knockdown on MM development. (bvsalud.org)
This article discusses how a combination of live-cell analysis methods deliver the required flexibility to allow these highly dynamic astrocytic models to be characterized, via quantification of their growth, motility, morphology, and functional analysis. (news-medical.net)

Oncogenic Ras induces p19ARF and growth arrest in mouse embryo fibroblasts lacking p21Cip1 and p27Kip1 without activating cyclin D-dependent kinases. (ku.dk)
induces growth arrest or apoptosis depending on the physiological circumstances and cell type. (lsbio.com)

In a complex organism like the body, cells are continuously differentiating. (cancer.gov)
The body must have a mechanism for dealing with these abnormal cells, or the organism will not live very long. (cancer.gov)
In this project, I aimed to understand how the APC/C coordinates the cell cycle with the cell specialisation process using the fruit fly, Drosophila melanogaster, as a model organism. (europa.eu)
Even the growth and development of every living organism depends on the growth and multiplication of its cells. (studyinnovations.com)
In multicellular organism also, new individual develop from a single cell. (studyinnovations.com)
As an analogy, we can compare an ecosystem to a super organism with species as analogs of cells in a multicellular animal. (atlasofscience.org)
Cell division is crucial for the proper development of any organism. (concordia.ca)

Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma. (nih.gov)
However, the biological function and prognostic value of TRPVs in clear cell renal cell carcinoma (ccRCC) are still largely unknown. (bvsalud.org)

Oogenesis in Eukaryotic Cells. (wikipedia.org)

Howard and Pelc (1953) first time described The sequence of events which occur during cell growth and cell division are collectively called cell cycle. (studyinnovations.com)

The right balance between these two fates of cells is essential not only for forming proper shapes of organs and tissues but also for maintaining their functions throughout the life of the organisms. (europa.eu)
Alternatively, all the cells may become specialised and stop producing new cells, which accelerates the degeneration of tissues or the ageing process. (europa.eu)
Radiation therapy works through the transfer of energy from ionizing radiation to molecules within tumor cells and related tissues. (medscape.com)
The scope of the special issue is to summarize and enlarge the knowledge in signalling processes and networks in diverse cells and tissues. (mdpi.com)

Many more investigations have been made on cells, sorted according to size, or artificially arrested at various cell cycle checkpoints. (frontiersin.org)

This report describes clonal, granulocyte-macrophage colony-stimulating factor-dependent myeloid cell lines that exhibit these properties. (nih.gov)

can arise if non-reproductive somatic cells protect their reproductive parents from environmental lethality. (groundwater-2011.net)
We suggest that the ability to arrest the cell cycle of child cells and redirect their source utilization from division to environmental danger amelioration is the important advancement of obligate multicellular eukaryotes, the nervous system developed to exercise this control over long distances, and that cancer is an escape by somatic cells from your control of reproductive cells. (groundwater-2011.net)

Radiation may also directly cause rapid cell death from mitotic arrest, point mutations in deoxyribonucleic acid (DNA), and cell membrane damage. (medscape.com)

Most studies have been performed on large cell populations, but detailed understanding of cell dynamics and heterogeneity requires single-cell analysis. (frontiersin.org)
This new field of study is called mitochondrial dynamics and it reveals how abnormalities in the life cycle of mitochondria (including the ways mitochondria divide (fission), join together (fusion) and are eliminated) result in disease causing changes in cell growth and survival. (queensu.ca)

We show that the effects on cell cycle progression stemmed from reduced ribosome content and translational capacity, which suppressed the accumulation of cyclins at the translational level. (nih.gov)
One important factor for cell growth is ribosome biogenesis. (uni-muenchen.de)
Mutation of the mouse ERB1 orthologue leads to G1 arrest and alters ribosome biosynthesis. (rupress.org)

Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. (kegg.jp)

Disrupting Pins polarity via overexpression of a myristoylated version of Pins caused randomized division angles. (elifesciences.org)

At the molecular level, abnormal cells that are potential cancer cells need to be "switched" to normal mode. (cancer.gov)
Groups of abnormal cells can arise under the influence of carcinogenic factors from outside or inside the body. (cancer.gov)
Queen's University professor Stephen Archer's (Department of Medicine) research has revealed that in serious human diseases (such as pulmonary hypertension, lung cancer, cardiac arrest and neurologic disease) the cell's power source, known as mitochondria, displays an abnormal structure. (queensu.ca)
Abnormal regulation of cell division or inappropriate triggering of apoptosis may contribute to the other health problems and unusual physical features that affect some people with Diamond-Blackfan anemia. (medlineplus.gov)

Mammalian oocytes are maintained in meiotic prophase arrest for a very long time-months in mice, years in humans. (wikipedia.org)
Maintenance of meiotic arrest also depends on the presence of a multilayered complex of cells, known as a follicle, that surrounds the oocyte. (wikipedia.org)
In the oocyte, cyclic GMP prevents the breakdown of cyclic AMP by the phosphodiesterase PDE3, and thus maintains meiotic arrest. (wikipedia.org)

and regulation of cell cycle process. (nih.gov)

To our knowledge, this is the first in vivo example where mechanical force has been shown to polarize Pins to mediate division orientation. (elifesciences.org)
Methods One week after immunization with peptide-pulsed dendritic cells, NKG2D signaling was transiently blocked in vivo with a single injection of neutralizing antibodies. (bmj.com)

Their cell lineage-specific effects are governed by chromatin structure. (edu.au)

These increased levels of p53 may initiate cell death. (wikipedia.org)
Newly synthesized Yph1p was required for cells to exit G 0 and initiate cell division. (rupress.org)

Meanwhile, Ibrance is a cell cycle inhibitor that targets CDK4 and CDK6, both important enzymes involved in cell division. (pharmalive.com)

Radiation interacts with intracellular water and produces free radicals that interfere with DNA synthesis, resulting in cell death. (medscape.com)

Two dividing cells in different phases of mitosis surrounded by interphase cells. (concordia.ca)
Controlled cell division, or mitosis, is crucial to the development of all living organisms. (concordia.ca)

Therefore, understanding how the division of the cells, i.e. the cell cycle, is coordinated with their responses to the external clues is key to understanding the causes of the formation and progression of tumours as well as the pathology of degenerative disorders, which will ultimately help develop new therapeutic strategies to these diseases. (europa.eu)
As the cell ages, cell cycles become more infrequent and ultimately division ceases. (atlasofscience.org)

Matches all models having model elements that were annotated with Gene Ontology term cell growth. (ebi.ac.uk)

CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. (kegg.jp)
Peak sensitivity to radiation is at the M and G2 phases of the cell reproductive cycle. (medscape.com)

The majority of glioblastomas are IDH wild-type and correspond to the longstanding clinical description of primary glioblastomas, which arise rapidly from non-neoplastic brain cells and progress quickly. (cancernetwork.com)
Cells that divide rapidly are most susceptible to radiation injury. (medscape.com)
Vaccination and T cell-based immunotherapy rely on one important feature of the adaptive immune system: the ability to form long-lasting memory cells able to rapidly respond to a second exposure with the same antigen [ 1 - 3 ]. (bmj.com)
This rapidly evolving discipline has already identified several new targets for therapy for diseases ranging from Parkinsonism and pulmonary hypertension to cardiac arrest. (queensu.ca)

Furthermore, directional ablations that separated mesoderm from mitotic domains disrupted spindle orientation, suggesting that forces transmitted from mesoderm to mitotic domains can polarize Pins and orient division during gastrulation. (elifesciences.org)
The finding that gastrulation-induced forces are required for asymmetric localization of an important and evolutionarily conserved spindle orientation factor, Pins, will be of broad interest to cell and developmental biologists. (elifesciences.org)
In Drosophila neuroblasts, asymmetric division and spindle orientation is dependent on Pins/LGN recruitment to the apical cortex. (elifesciences.org)
In symmetric epithelial cell divisions, spindle orientation also depends on Pins, which is recruited to the lateral cortex by the lateral domain protein, Discs large (Dlg). (elifesciences.org)
Oocyte meiosis, important to all animal life cycles yet unlike all other instances of animal cell division, occurs completely without the aid of spindle -coordinating centrosomes . (wikipedia.org)

The molecular processes behind cell cycle progression have been dissected by numerous morphological studies on live or fixed single cells using a plethora of techniques to visualize components and processes during cell division. (frontiersin.org)
We propose that for the immune system to populate the memory compartment with the best-suited CD8 T cells it utilizes a process of certification or molecular accreditation mediated through Natural Killer Group 2D (NKG2D). (bmj.com)

By constructing stability diagrams showing domains of periodic behavior as a function of the maximum rates of the kinases and phosphatases involved in the two cycles of the cascade, we investigate the role of these converter enzymes in the oscillatory mechanism. (ebi.ac.uk)
The results suggest ways to arrest the mitotic oscillator by altering the maximum rates of the converter enzymes. (ebi.ac.uk)

Moreover, alkaline phosphatase activity was equally detectable after depletion of Pes1 or Bop1 and no morphological changes within the ES cell colonies were observed. (uni-muenchen.de)
Immortalized rodent fibroblast cell lines that lack INK4a/ARF function, ARF alone, or p53 are resistant to the growth inhibitory effects of oncogenic Ras and instead continue to proliferate and undergo morphological transformation. (ku.dk)
Astrocytes are a heterogeneous population of cells with distinguishing functional and morphological characteristics and are specialized to their different brain regions and locations. (news-medical.net)

Once in this cell cycle arrested state, the cell undergoes lysis. (atlasofscience.org)

This explosion in the understanding of the once secret lives of mitochondria will almost certainly advance our understanding of an important mechanism for cell death and cell growth," says Dr. Archer. (queensu.ca)

Aging/death programs such as senescence, apoptosis and autophagy are not adaptive to the affected cells, but these cells, while aging, give directions to nearby cells and thereby modify their behavior. (atlasofscience.org)
In essence within the context of the whole animal, the aging and death of individual cells makes possible essential whole animal functions i.e. the aging/death of individual cells is beneficial to the functioning of the whole animal. (atlasofscience.org)
Another possibility is cell death during mitotic arrest. (smpdb.ca)
Alternatively, mitotic catastrophe may occur and cause cell death. (smpdb.ca)

Interleukin-15 (IL-15) is one the most well described factors needed for survival and homeostasis of memory and memory precursor cells, as blocking IL-15 signaling strongly reduces the number of memory CD8 T cells [ 4 , 5 ]. (bmj.com)

Period of synthesis and duplication of various components of cell). (studyinnovations.com)

Mature cell divides into two cells). (studyinnovations.com)

It is a type of targeted cancer treatment, meaning that instead of indiscriminately killing cells the way that chemotherapy does, Velcade is designed to seek out cancer cells in the body and kill them. (lymphomainfo.net)
Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. (researchsquare.com)
By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. (researchsquare.com)
Previous studies in our laboratory have described increased and preferential radiosensitization of mismatch repair-deficient (MMR − ) HCT116 colon cancer cells with 5-iododeoxyuridine (IUdR). (aacrjournals.org)
This can be used as a new weapon to fight against cancer cells by completely eradicating them.It blocks harmful chemicals that are released by cancer cells, and these chemicals cause damage to healthy cells. (fenbenmed.com)
Fenbendazole is best for reducing cancer cells in humans. (fenbenmed.com)
Medical studies have shown that fenbendazole reduced the number of cancer cells in patients who were suffering from cancer.Fenbendazole is one of the most frequently prescribed drugs for human Echinococcosis. (fenbenmed.com)
Fenbendazole works by slowing or stopping the growth of cancer cells and responding to cell damage. (fenbenmed.com)
The cause of this type of cancer is unknown.Some studies have also found that Fenbendazole may help prevent the spread of cancer cells . (fenbenmed.com)
A drug called Fenbendazole is effective against cancer cells and has been used for many years in medicine. (fenbenmed.com)
Fenbendazole is an anticancer drug that is effective in killing cancer cells. (fenbenmed.com)
When this enzyme is blocked, cancer cells cannot grow and multiply by dividing into two new cells.The researchers found that Fenbendazole could kill lung cancer cells, prostate cancer cells, breast cancer cells, and melanoma cells with equal effectiveness. (fenbenmed.com)
The dream is to develop an anti-cancer drug that targets and stops unregulated cell division caused by cancer cells. (concordia.ca)
However, cancer cells hijack the machinery controlling division. (concordia.ca)
The mechanism it targets appears to be selective to highly progressive cancer cells. (concordia.ca)

Anatomy30

Organisms17

Diseases3

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes83

Disciplines and Occupations1

Information Science4

Health Care1

Proliferation26

Differentiation14

Regulating cell cycle progression1

Apoptosis and cell2

Genetically identical3

Pathways2

Inhibition5

Signaling pathway2

Tumors3

Mitotic cell cycle1

Metaphase4

Involved in ribosome biogenesis2

Kinase14

Induce4

Embryonic2

Epithelial cells3

Genes14

Checkpoint5

Cellular5

Vitro5

Proteins8

Progression through the cell cycle1

Unicellular organisms1

Mechanisms2

Replicative1

Motility3

Growth arrest2

Organism7

Renal cell carc2

Eukaryotic cells1

Collectively called1

Tissues4

Checkpoints1

Myeloid cell1

Somatic cells2

Mutations1

Dynamics2

Ribosome3

Cyclin1

Polarity1

Abnormal4

Meiotic3

Regulation of cell cycle1

Vivo2

Lineage1

Initiate cell2

Inhibitor1

Intracellular1

Mitosis2

Ultimately2

Gene Ontology1

Phases of the cell2

Rapidly4

Spindle5

Molecular2

Enzymes2

Morphological3

Undergoes1

Mitochondria1

Death4

Strongly1

Synthesis1

Mature1

Cancer cells15