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  • asymmetric cell div
  • The article "Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus" is by Genetics, Bioinformatics, and Computational Biology graduate student Shenghua Li, research scientist Paul Brazhnik, Professor and Director of VBI's Cyberinfrastructure Group Bruno Sobral, and University Distinguished Professor of Biological Sciences John Tyson. (eurekalert.org)
  • Caulobacter
  • The mathematical model described in the paper allows researchers to study and analyze the systems-level dynamics of the Caulobacter cell cycle, test hypotheses and suggest crucial new experiments. (eurekalert.org)
  • Caulobacter normally undergoes a cell cycle that produces two different types of offspring: a motile "swarmer cell" with a flagellum, a slender thread-like structure that allows the bacterium to swim, and an immobile "sessile stalked cell" that lacks a flagellum. (eurekalert.org)
  • However, prokaryotic cells like Caulobacter have been somewhat neglected as information systems in studies by scientists. (eurekalert.org)
  • mutations
  • Taking this one step further, they were also able to simulate the impact of specific known mutations on cell function. (eurekalert.org)
  • precise
  • While computers are precise, digital processors, cells are analog systems that operate for the most part in sloppy, watery environments. (eurekalert.org)
  • proteins
  • The new math model allows scientists to investigate how these proteins vary with time and their link to physiological events in both stalked and swarmer cells. (eurekalert.org)
  • They were able to show in simulations that the model accurately describes how the different proteins change in quantity during the cell division cycle. (eurekalert.org)
  • sequence
  • With the model in place, the researchers confirmed that it correctly represents the sequence of physiological events that take place during cell division. (eurekalert.org)