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  • Inhibition
  • There was evidence that Cdc42 inhibition by AZA197 treatment suppresses proliferative and pro-survival signaling pathways via PAK1-ERK signaling and reduces colon cancer cell migration and invasion. (wikipedia.org)
  • yeast
  • CDC34 was originally discovered by work in baker's yeast as a gene that has a role in the cell division cycle. (wikipedia.org)
  • E. coli, B. subtilis, yeast, CHO- or human cell lines Bioprocess development and optimization e.g. optimization of product yields Simulation of oncological clinical trials exploiting grid computing infrastructures, such as the European Grid Infrastructure, for improving the performance and effectiveness of the simulations. (wikipedia.org)
  • CDC16
  • We report gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 and APC8/CDC23 (zeige CDC23 Antikörper ) which are known to be key function elements. (antikoerper-online.de)
  • Cdc25C
  • Xanthatin functions as a DNA-damaging agent in non-small cell lung carcinomas by activating Chk1-mediated DDR and lysosome-mediated degradation of Cdc25C. (nih.gov)
  • activates
  • Activated Cdc42 activates by conformational changes p21-activated kinases PAK1 and PAK2, which in turn initiate actin reorganization and regulate cell adhesion, migration, and invasion. (wikipedia.org)
  • CDC25A
  • CDC25A plays a novel role in regulating the malignant behavior of glioma stem cells as a part of Linc00152/miR-103a-3p/FEZF1/CDC25A axis. (nih.gov)
  • CDC25A is specifically degraded in reaction to DNA damage, which inhibits cells with chromosomal abnormalities from progressing in the course of cell division. (prospecbio.com)
  • cellular
  • All organisms (single and multi-cellular) rely upon reiteration of growth and division of existing cells under favorable conditions. (antibodies-online.com)
  • More work can be found that focus on modeling a particular cellular process such as the growth cycle of Caulobacter crescentus. (wikipedia.org)
  • cyclin
  • Accordingly, specific cyclin-CDK complexes persist in an active form for a very short period of time after translation, and are then degraded or inactivated by the time that particular phase of the cell cycle completes. (antibodies-online.com)
  • Activation of specific cyclin-CDK complexes are characteristic for the different cell cycle phases, and drive production of specific molecules associated with, and necessary for that phase of division. (antibodies-online.com)
  • Biology
  • Nature Cell Biology. (wikipedia.org)
  • Limitations in the understanding of molecular dynamics and cell biology as well as the absence of available computer processing power force large simplifying assumptions that constrain the usefulness of present in silico cell models. (wikipedia.org)