• The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies on the biochemistry and function of cells in situ are especially encouraged . (wiley.com)
  • Neuregulin1α, which drives mucus cell differentiation in vitro, was expressed in normal airway submucosal glands and in lungs from patients with IPF. (bmj.com)
  • Expansion of MSCs was shown to be limited to a few passages of in vitro culture and the cells underwent replicative senescence [ 11 ]. (hindawi.com)
  • Changes in the differentiation potential of MSCs after in vitro expansion were noted and chondrogenic clones especially disappeared early on [ 12 ]. (hindawi.com)
  • Therefore, available in vitro protocols for expansion of MSCs do not yield true stem cells. (hindawi.com)
  • Dr. Goswami, principal scientist at the Indian Council of Agricultural Research, is studying in vitro differentiation of carp embryonic, myogenic, and adipogenic stem cells in collaboration with the Ovissipour Lab at Virginia Tech. (gfi.org)
  • Finally, the GM-I and Cedars-Sinai research team has developed a technology development strategy that translates the gamma microscope technology, useful for in vitro and in vivo mouse imaging, into future clinical applications involving the monitoring of stem cells and their progeny as well as the biological processes associated with the differentiation stages. (ca.gov)
  • Hematopoietic Stem Cell and Leukaemic Stem Cell environmental stress responses (In vitro biomimicry of hypoxia, normoxia, hypothermia, hyperthermia, hypoglycemia and hyperglycemia): Effect on cellular growth, cell cycle distribution, apoptosis and cellular metabolism. (imperial.ac.uk)
  • This work will develop new cell lines for cultivated seafood production, provide insights into the relative merits of embryonic and adult stem cells as starting materials, and improve our ability to control the myogenic and adipogenic differentiation processes. (gfi.org)
  • We show that oMAP4 is expressed upon muscle cell differentiation and is the only MAP4 isoform essential for normal progression of the myogenic differentiation programme. (elifesciences.org)
  • This project aims to develop continuous cell lines from carp and characterize their adipogenic and myogenic differentiation. (gfi.org)
  • Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
  • Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)
  • To understand how the genome and epigenome regulates cellular function, development of high-throughput sequencing methods, known as next-generation sequencing, are beginning to unravel genome-wide correlations between the genome, epigenome and transcriptome within a large population of cells or tissues. (confex.com)
  • Thus, my research interests are to develop novel single-cell genomics methods to better understand how changes in the epigenetic landscape during normal development regulates cellular differentiation, information that is critical towards realizing the full potential of regenerative medicine. (confex.com)
  • In this Review, we briefly outline the roles that follicle-stimulating hormone (FSH) and testosterone play in regulating spermatogenesis and describe our current understanding of how vitamin A regulates germ cell differentiation and how it may lead to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave. (jci.org)
  • It produces 2 hormones: vasopressin, which causes blood pressure to rise and regulates the amount of water in the body's cells, and oxytocin, which causes the uterus to contract during childbirth and lactation to begin. (medscape.com)
  • Functional profiling reveals critical role for miRNA in differentiation of human mesenchymal stem cells. (ac.ir)
  • Mesenchymal stem/stromal cells (MSC) are the ideal source to study fat formation as they are the progenitors of adipocytes. (mdpi.com)
  • Osteoblast mainly originates from mesenchymal stem cells (MSCs), and it is involved in bone formation, remodeling, and reconstruction via the formation of a bone matrix and regulation of bone resorption ( 6 ). (frontiersin.org)
  • However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
  • Radioactive labeling of cells is an established technique and our research group demonstrated the ability to image 111In labeled mesenchymal stem cells for up to 10 days. (ca.gov)
  • Fig. 3: Single-cell transcriptomics of dorsal and ventral MiSTR tissues. (nature.com)
  • More specifically, regenerative medicine has recently emerged as a promising therapeutic strategy for treating degenerating tissues using different types of stem cells. (confex.com)
  • However, the full promise of regenerative medicine has been difficult to achieve so far, partly due to our incomplete understanding of the genetic and epigenetic mechanisms regulating differentiation of stem cells to specific lineages and tissues. (confex.com)
  • Because tissues are composed of several cell-types and even cells within the same cell-type have been shown to display dramatic cell-to-cell variability in gene expression, bulk measurements obscure quantification of how genetic or epigenetic features directly influence the function of individual cells. (confex.com)
  • In this work, pathways governing mucus cell differentiation were investigated in lung tissues from patients with IPF and other chronic pulmonary disorders. (bmj.com)
  • Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)
  • Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
  • Alkaline phosphatase (ALP), osteocalcin (OCN), osteopontin (OPN), and runt-related transcription factor 2 (Runx2) are commonly used to evaluate differentiation and maturation of osteoblasts. (frontiersin.org)
  • Specifically, the protein controls the activity of genes that regulate cell growth and division (proliferation), cell maturation and specialization (differentiation), cell movement (migration), and cell survival. (medlineplus.gov)
  • Recently, miRNA-messenger RNA (mRNA) regulatory relationships have been confirmed during biological processes, including osteogenic differentiation. (frontiersin.org)
  • Apoptosis is essential for many fundamental processes, such as embryogenesis and tissue homeostasis. (nature.com)
  • Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
  • Fig. 1: Design of the MiSTR cell culture system and establishment of a WNT signaling gradient in hESC-derived tissue. (nature.com)
  • Cell Biochemistry & Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease . (wiley.com)
  • breathing, tissue settling, muscular motion, GM-I is developing correction techniques that follow the motions in real time and compensate for motion blurring of the cells under study. (ca.gov)
  • Both miRNAs and siRNAs need to be delivered into the target tissue or cell in order to activate the desired therapeutic effect," Muthiah Manoharan, Ph.D., senior vp, drug discovery, Alnylam Pharmaceuticals, explained. (genengnews.com)
  • Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
  • Further, while cell-to-cell heterogeneity in gene expression has been shown to drive dramatic phenotypic variations, the upstream epigenetic mechanisms regulating this heterogeneity remain largely unknown 8 . (confex.com)
  • The authors sought to identify mechanisms driving the differentiation of mucus cells during the bronchiolisation process. (bmj.com)
  • To test the relevance of ADF/cofilin activity for apoptotic processes, we here employed a genetically well-defined system of mouse embryonic fibroblasts (MEFs) devoid of any ADF/cofilin activity and challenged these cells with well-characterized apoptosis inducers. (nature.com)
  • The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. (wikipedia.org)
  • Per usual in non-apoptotic growing cells caspase activated dnase is held in check inactivated in the cytoplasm thanks to the association with its inhibitor, inhibitor of caspase-activated DNase (ICAD) also known as DNA fragmentation factor 45 kDa (DFF45). (wikipedia.org)
  • Caspase-3 is activated in the apoptotic cell. (wikipedia.org)
  • The ultrastructural study of the cellular modifications (during the life cycle reversion of T. nutricula) showed the presence of both degenerative and apoptotic processes. (researchgate.net)
  • The significant presence of degenerative and apoptotic processes could be related to the occurrence of a sort of metamorphosis when an adult medusa transforms itself into a polyp. (researchgate.net)
  • nutricula ) showed the presence of both degenerative and apoptotic processes. (researchgate.net)
  • Human neuronal stem cell and induced pluripotent stem cell, iPSC, cultures are of high scientific and practical interest in drug discovery, toxicology and for future therapeutic applications. (neuroproof.com)
  • To understand the differentiation process of these stem cell cultures into neurons is an important and complex task and an essential prerequisite for the functional characterization of test compounds in a human cellular background.These iPSC cultures can be differentiated to different neuron cell type cultures as glutamatergic, gabaergic, dopaminergic or motoneurons and others for further information see also on our stem cells technology page. (neuroproof.com)
  • We compare stem cell-derived neuronal network activity patterns with primary cell recordings. (neuroproof.com)
  • MPP+ disturbs the developmental differentiation process of these stem cell derived cultures, which can be rescued by GDNF in this stem cell based assay. (neuroproof.com)
  • GDNF rescues MPP+ effects in human stem cell cultures and primary ventral midbrain cultures from mouse. (neuroproof.com)
  • The approach, named microfluidic-controlled stem cell regionalization (MiSTR), exposes pluripotent stem cells to signaling gradients that mimic developmental patterning. (nature.com)
  • Stem Cell Rep. 3 , 987-999 (2014). (nature.com)
  • Undifferentiated spermatogonia divide mitotically to both repopulate the testicular stem cell population and provide progenitor cells that undergo spermatogenesis. (jci.org)
  • Overview of studies published regarding MSCs using the term "stem cell" or "stromal cell" in the last 20 years accessed by a web search in July 2015 (Google Scholar). (hindawi.com)
  • It seems that the term "stem cell" became more popular although the "stemness" was only shown in a more strict sense for MSCs involved in osteogenesis and bone repair. (hindawi.com)
  • When the biological properties of MSCs were explored in more detail, questions arose whether these cells met the criterion of a true stem cell [ 8 ]. (hindawi.com)
  • To qualify as a stem cell, these cells must be able to self-renew, most likely by symmetric cell division to produce two daughter cells with the same stem cell qualities. (hindawi.com)
  • Overview on self-renewal or differentiation of stem cells in their respective stem cell niche. (hindawi.com)
  • MSCs were also investigated for stem cell qualities in vivo. (hindawi.com)
  • and 3) imaging of stem cell differentiation. (ca.gov)
  • The imaging of stem cell differentiation is possible by linking promoters - in this case a bone-forming promoter known as human Osteocalcin (hOc) - with the expression of hNIS. (ca.gov)
  • Cedars' research group successfully demonstrated the expression of the reporter hNIS in MSCs that had differentiated into bone-forming cells - demonstrating the ability to image stem cell differentiation long after the transfection of the reporter gene into the original MSC population. (ca.gov)
  • Stem cell scaffold bioprocessing. (imperial.ac.uk)
  • Three dimensional stem cell culture systems. (imperial.ac.uk)
  • Mathematical modeling of Hematopoietic Stem Cell and Leukaemic Stem Cell culture systems. (imperial.ac.uk)
  • The main stages of animal embryonic development are as follows: The zygote undergoes a series of cell divisions (called cleavage) to form a structure called a morula. (wikipedia.org)
  • Caspase-3 activation is a cell requirement during early stages of the skeletal myoblast differentiation. (wikipedia.org)
  • The aim of the present study was to investigate the expression of this miRNA, called SPTBN4-miR1 , in the process of differentiation of human embryonal carcinoma cell line NT2 and also the overexpression effect of this miRNA on the differentiation of these cells. (ac.ir)
  • This study aimed to find out more candidate miRNA-mRNA pairs involved in the osteogenic differentiation of MC3T3-E1 cells. (frontiersin.org)
  • There were 7 overlapped miRNA-mRNA pairs identified during osteogenic differentiation of MC3T3-E1 cells, including mmu-miR-204-5p-Arhgap11a, mmu-miR-211-5p-Arhgap11a, mmu-miR-24-3p-H2afx, mmu-miR-3470b-Chek2, mmu-miR-3470b-Dlgap5, mmu-miR-466b-3p-Chek1, and mmu-miR-466c-3p-Chek1. (frontiersin.org)
  • The expression of miRNA is deregulated in several pathological processes, including cancer. (bvsalud.org)
  • Depending on the context and the cell is type they are expressed, one can view miRNA oncogenic or tumor suppressor activity. (bvsalud.org)
  • Thus, the function of miRNA may ultimately depend on the specific microenvironment of a particular cell type, which can provide different repertoire of target genes. (bvsalud.org)
  • This feature occurs because a shortage of the ALX4 transcription factor caused by deletion of the gene disrupts several cellular processes and impairs proper bone formation (ossification). (medlineplus.gov)
  • Depletion of oMAP4 impairs cell elongation and cell-cell fusion. (elifesciences.org)
  • The SPTBN4 gene, a part of the spectrin protein family, plays important roles in various cellular processes, including cell cycle, nerve cell development, and so on. (ac.ir)
  • Caspase 3 is responsible for cellular differentiation, although it is unclear how this kind of protein can promote the cell apoptosis. (wikipedia.org)
  • This protein is also involved in the formation of skin layers, but its role in this process is poorly understood. (medlineplus.gov)
  • As a result, the protein cannot bind to DNA and regulate gene function, which leads to poorly controlled cell proliferation and migration during development. (medlineplus.gov)
  • Spider silk is classified as keratin, [9] although production of the protein may have evolved independently of the process in vertebrates. (wikipedia.org)
  • The microtubules in cells that make smaller amounts of this protein were more disorganised, and these cells were unable to fuse with each other to form muscle cells. (elifesciences.org)
  • These observations support the hypothesis that axonal influences affect oligodendrocyte survival, differentiation, and expression of proteolipid protein gene products. (rupress.org)
  • The zygote undergoes mitotic divisions with no significant growth (a process known as cleavage) and cellular differentiation, leading to development of a multicellular embryo after passing through an organizational checkpoint during mid-embryogenesis. (wikipedia.org)
  • The microtubule cytoskeleton is critical for muscle cell differentiation and undergoes reorganisation into an array of paraxial microtubules, which serves as template for contractile sarcomere formation. (elifesciences.org)
  • Runx2 belongs to the Run family and is an essential upstream transcription factor during osteoblast differentiation. (frontiersin.org)
  • Thus, we conclude that ADF/cofilin activity is not generally required for induction or progression of apoptosis in mammalian cells. (nature.com)
  • In summary, our work demonstrates that in mammalian cells ADF/cofilin activity is not generally required for efficient induction of apoptosis. (nature.com)
  • Apoptosis is a cell self-destruct process that removes toxic and/or useless cells during mammalian development and other life processes. (wikipedia.org)
  • Then, after overexpressing the SPTBN4-miR1 precursor in NT2 cells and retinoic acid treatment, the expression of pluripotent and differentiation revealed the role of SPTBN4-miR1-5p and SPTBN4-miR1-3p in promoting differentiation and exclusion from the pluripotent state. (ac.ir)
  • Glutamatergic and dopaminergic hIPSC derived neural cultures develop synchron activity patterns over time comaparable to primary neuronal cell cultures. (neuroproof.com)
  • Here, we model early human neural tube development using human embryonic stem cells cultured in a microfluidic device. (nature.com)
  • Single-cell transcriptomics revealed that rostro-caudal organization was already established at 24 h of differentiation, and that the first markers of a neural-specific transcription program emerged in the rostral cells at 48 h. (nature.com)
  • Thus, MiSTR will facilitate research on the factors and processes underlying rostro-caudal neural tube patterning. (nature.com)
  • 3D reconstitution of the patterned neural tube from embryonic stem cells. (nature.com)
  • RT-qPCR results indicate that SPTBN4-miR1-5p and SPTBN4-miR1-3p show a significant increase in expression in the process of neural differentiation from day three until the 8th and 14th day of differentiation. (ac.ir)
  • MicroRNAs (miRNAs) are master regulators involved in multiple physiological and pathological processes. (genengnews.com)
  • The results show that lysophosphatidic acid signalling pathways influence retraction of processes in oligodendrocyte precursors but that this effect changes as oligodendrocytes differentiate. (nih.gov)
  • Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
  • In animals, the process involves a sperm fusing with an ovum, which eventually leads to the development of an embryo. (wikipedia.org)
  • Our study characterizes miR-211-5p targeting Arhgap11a promotes the osteogenic differentiation of MC3T3-E1 cells, which provides novel targets to promote the osteogenesis process during bone repair. (frontiersin.org)
  • Specifically, cells in the skull that are involved in bone formation (ossification) cannot function normally, leading to a lack of bone in areas of the skull and resulting in enlarged parietal foramina. (medlineplus.gov)
  • Today, more than 50 years after the first successful bone marrow transplantation, clinical application of hematopoietic stem cells is a routine procedure, saving the lives of many every day. (hindawi.com)
  • The MSCs have been described for the first time as colony forming fibroblasts (CFU-F), a rare population of cells residing in the bone marrow of guinea-pigs or mice [ 1 , 2 ]. (hindawi.com)
  • Cancer cells, particularly those arising from the bone marrow or lymphatic system, may have a short generation time, and there usually are a smaller percentage of cells in G0 (resting phase). (msdmanuals.com)
  • Importantly, the mitochondrial association of n-cofilin and ADF had no impact on apoptosis signaling because ablation of either n-cofilin, ADF, or both proteins together did not change cell death progression. (nature.com)
  • Keratin also protects epithelial cells from damage or stress. (wikipedia.org)
  • They are also present in epithelial cells in general. (wikipedia.org)
  • For example, mouse thymic epithelial cells react with antibodies for keratin 5, keratin 8, and keratin 14. (wikipedia.org)
  • These antibodies are used as fluorescent markers to distinguish subsets of mouse thymic epithelial cells in genetic studies of the thymus . (wikipedia.org)
  • NRG1α was detected in serous cells within normal submucosal glands and in epithelial cells lining honeycombing areas in IPF, and was not detected in other patients. (bmj.com)
  • Conclusion Expression of SOX2 and MUC5B and lack of SPDEF in atypically differentiated cells of bronchiolised distal airspaces are consistent with abnormal programming of airway epithelial cells in IPF. (bmj.com)
  • Previous studies have indicated that newly formed oligodendrocytes are dynamic cells whose production, survival, and differentiation depend upon axonal influences. (rupress.org)
  • The Arhgap11a, H2afx, Chek2, Dlgap5, and Chek1 were hub genes downregulated in MC3T3-E1 cells after osteogenic differentiation, verified by RT-qPCR results. (frontiersin.org)
  • This abnormal cell growth and movement leads to malformations in the middle of the face, particularly affecting the nose, which leads to openings (clefts) in the nose. (medlineplus.gov)
  • Abnormal differentiation of the respiratory epithelium is a feature of idiopathic pulmonary fibrosis (IPF). (bmj.com)
  • Mucus cells lining abnormal airways from patients with IPF expressed MUC5B and SOX2 but lacked SAM pointed domain containing ETS transcription factor (SPDEF) and forkhead box A3(FOXA3). (bmj.com)
  • Activation of abnormal respiratory epithelial differentiation programs may contribute to the expression of MUC5B and bronchiolisation of the distal lung, a salient feature of IPF. (bmj.com)
  • We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies. (hindawi.com)
  • Primary neuronal cell cultures from mouse and iPSC derived neuronal cultures show similar activity development over time. (neuroproof.com)
  • Embryonic development starts with the fertilization of an egg cell (ovum) by a sperm cell, (spermatozoon). (wikipedia.org)
  • Quantitative Biology of Development & Stem Cells, Hubrecht Institute, The Netherlands. (confex.com)
  • Similarly, in specific cases, such as cancers, viral infections and in certain cell-types during normal development, mutations and other structural variations within the genome also influences cellular functions. (confex.com)
  • The molecular study of fat cell development in the human body is essential for our understanding of obesity and related diseases. (mdpi.com)
  • The regulation of these functions ensures that cells start and stop growing at specific times and that they are positioned correctly during development. (medlineplus.gov)
  • Dr. Goswami has a strong background in molecular biology and experience in the development and characterization of fish cell lines. (gfi.org)
  • Dr. Duscher's research focuses on optimizing cost-effective and efficient fish cell culture for the development of cultivated seafood. (gfi.org)
  • and 2) development of new imaging hardware, a gamma microscope, to visualize the individual stem cells in vivo. (ca.gov)
  • The endocrine system-the other communication system in the body-is made up of endocrine glands that produce hormones, chemical substances released into the bloodstream to guide processes such as metabolism, growth, and sexual development. (medscape.com)
  • A cancer may release cells into the circulation at a very early stage of development. (msdmanuals.com)
  • Skeletal muscle fibre formation requires a coordinated programme of morphological and biochemical changes in the differentiating cells. (elifesciences.org)
  • Katholieke Universiteit Leuven, Faculty of Engineering, Department of Chemical Engineering, Chemical and Biochemical Process Technology and Control Laboratory: PhD candidate. (imperial.ac.uk)
  • From an engineering perspective, gene expression regulation can be viewed as the output of a network of complex chemical and physical processes, and understanding how these processes interact and integrate to govern cellular phenotypes has been a major focus of my graduate and postdoctoral research. (confex.com)
  • An MC3T3-E1-based microarray dataset (accessioned as GSE46400) downloaded from the Gene Expression Omnibus included MC3T3-E1 cells with or without 14-day osteoblast differentiation osteoblast induction. (frontiersin.org)
  • This "reporter gene" imaging technique works not only with the originally engineered cells but also with the progeny cells that result from splitting and differentiation of the stem cells. (ca.gov)
  • This is a dramatic improvement in the ability to visualize stem cells the hNIS gene stays with the descendents of the originally transfected cells and they will temporarily "shine" or become visible when 99mTc is injected into the body as a contrast tracer. (ca.gov)
  • CAD leads to the initiation of the DNA strand breakage, which occurs during terminal differentiation of some cell, such as skeletal muscle cell. (wikipedia.org)
  • C ) Expansion of both the undifferentiated (A spermatogonia) and differentiated (A1 spermatogonia) spermatogonial populations occurs by mitosis of these cell types, regulated in part by FSH. (jci.org)
  • Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)
  • We demonstrate here that lysophosphatidic acid induces process retraction in central glia-4 cells and oligodendrocyte precursors. (nih.gov)
  • Transcription and processing of human microRNA precursors. (ac.ir)
  • The cell diversity is originated by cell differentiation, which has been attributed to the activation of specific transcription factors. (wikipedia.org)
  • Osterix (OSX) is a transcription factor in the SP family, which is essential for osteoblast differentiation, and its expression is closely related to Runx2 ( 9 ). (frontiersin.org)
  • Singularly, SPDEF, a transcription factor associated with mucus metaplasia, was rarely detected in mucus cells in IPF. (bmj.com)
  • At the same time, by asymmetric cell division or after specific activation, stem cells must be able to generate more mature progenitor cells or differentiated effector cells (Figure 1 ). (hindawi.com)
  • The genome within all cell-types of a multicellular organism is identical, yet different cell-types display varied functions within an organism due to differences in other factors, collectively termed as the epigenome. (confex.com)
  • Having more than five years of experience with hiPSC neuron recordings, we optimize your culture protocols based on functional activity readouts and compare their activity with commercially available reference cell lines. (neuroproof.com)
  • Cell division with no significant growth, producing a cluster of cells that is the same size as the original zygote, is called cleavage. (wikipedia.org)
  • Cell Death Differ, 2023 May. (nih.gov)
  • Hosseini F, Mohamad Soltani B, Baharvand H, Hosseinkhani S. Investigation of the Expression and the Effect of SPTBN4-miR1 in Process of Nerve Differentiation of NT2 Cells. (ac.ir)
  • MiR-211-5p upregulation by its mimic increased Arhgap11a expression in MC3T3-E1 cells. (frontiersin.org)
  • To overcome this limitation, recent advances in molecular biology have enabled genome-wide single-cell measurements of the transcriptome, genome or certain epigenetic marks that capture this cell-to-cell heterogeneity. (confex.com)
  • and negative regulation of cell population proliferation. (nih.gov)
  • The structure, regulation, and cell types of the mouse testis. (jci.org)
  • These hormones regulate the body's growth, and are involved in cell to cell communication, control metabolic activity, sleep-wake homeostasis, and altered regulation or dysregulation of adaptive response in various physiologic and pathophysiologic states. (medscape.com)
  • The egg cell is generally asymmetric, having an animal pole (future ectoderm). (wikipedia.org)
  • A Novel SPECT microscopy system for 3D imaging of single stem cells in vivo Individual stem cells can be visualized within the body - "in vivo" by genetically engineering the cells to absorb a contrast agent when the agent is present within the body. (ca.gov)
  • Project: Developing novel single-cell genomics methods to quantify cell-to-cell heterogeneity in cancers and stem cells. (confex.com)
  • We have developed and established protocols for human iPSC neurons on microelectrode arrays, MEAs, together with our commercial partners who offer iPSC-neurons and neuronal progenitor cells, NPC's. (neuroproof.com)
  • Human iPSC derived neuronal cell cultures cultivated on microelectrode arrays. (neuroproof.com)
  • Consequently, several human diseases, including cancer and neurodegenerative disorders, are caused by defects in this highly regulated form of cell death. (nature.com)
  • The human oviduct, also known as the fallopian tube, is an essential component of the normal reproductive process. (medscape.com)
  • In order to test the microscope, a miniature pattern of cell-sized reservoirs in a microfluidic slides is being developed. (ca.gov)
  • Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
  • 200 cells/mm3 or a clinical stage 3 or 4 event. (cdc.gov)
  • 100 cells/mm3 or WHO clinical stage 3 or 4. (cdc.gov)
  • In amniotes, the cells of the morula are at first closely aggregated, but soon they become arranged into an outer or peripheral layer, the trophoblast, which does not contribute to the formation of the embryo proper, and an inner cell mass, from which the embryo is developed. (wikipedia.org)
  • It is inhibited by pre-treatment of cells with C3 exoenzyme, a specific inhibitor of Rho, or with Y-27632, a specific inhibitor of ROCK, a downstream kinase of Rho. (nih.gov)
  • Cell Biochemistry and Function currently does not publish research in specific areas that are better served by specialist journals. (wiley.com)
  • Cell Biochemistry & Function also discourages submission of research based exclusively on analysis of publically available transcriptomic and proteomic datasets, although the acceptability of specific manuscripts in this particular area can be discussed with the Editor-in-Chief. (wiley.com)
  • The endocrine system consists of endocrine glands that produce and secrete hormones into the blood stream to reach and act on target cells of specific organs. (medscape.com)
  • Some drugs work only during a specific phase of the cell cycle, requiring prolonged administration to catch dividing cells during the phase of maximal sensitivity. (msdmanuals.com)