Cell differentiation granulocyte precursor cells. Medical search. Frequent questions

In contrast to authentic osteoclasts, MNC reacted with a monoclonal antibody (Mo1) which identifies an antigen present on myeloblasts, monocytes, granulocytes, and null cells from human peripheral blood and bone marrow. (elsevierpure.com)
However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and neutrophils. (frontiersin.org)
Myeloid innate immune cells, such as granulocytes, monocytes, macrophages and dendritic cells (DCs), play an important role in cancer-cell recognition, initiation of inflammation and antitumor responses ( 2 ). (frontiersin.org)
Cells within the hematopoietic islets in the bone marrow contain red blood cells, granulocytes ( neutrophils , eosinophils , basophils ), monocytes and macrophages , lymphocytes , platelets , and their precursors. (wikilectures.eu)
CFU-E for red blood cells and CFU-GM for cells that form granulocytes and monocytes). (wikilectures.eu)

Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. (uchicago.edu)
Macrophages, which are functional plasticity cells, have the ability to phagocytize and digest foreign substances and acquire pro-(M1-like) or anti-inflammatory (M2-like) phenotypes according to their microenvironment. (frontiersin.org)
The large number of macrophages in the intestinal tract, play a significant role in maintaining the homeostasis of microorganisms on the surface of the intestinal mucosa and in the continuous renewal of intestinal epithelial cells. (frontiersin.org)
In addition, the effects of macrophages in the occurrence and development of inflammatory bowel disease (IBD), and their role in inducing fibrosis, activating T cells, reducing colitis, and treating intestinal inflammation were also reviewed in this paper. (frontiersin.org)
On the other hand, phagosomes are formed when the pathogen is engulfed by macrophages and fuse with lysosomes to release enzymes and toxic substances, resulting in killing or having cytotoxic effects on bacteria and tumor cells. (frontiersin.org)
The lamina propria of the small intestine is the main site of the intestinal immune system, which contains a large number of macrophages, CD4 T cells, and dendritic cells. (frontiersin.org)
Granulocyte/macrophage - Colony-stimulating factor (GM-CSF) is a hematopoietic factor that is produced by activated T-cells, B-cells, mast cells, macrophages, fibroblasts, and endothelial cells. (neobiotechnologies.com)
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (neobiotechnologies.com)
The microenvironment, consisting of lymphocytes, macrophages, fibroblasts, endothelial elements, and stroma in which hematopoietic cells reside, creates a regulatory niche that determines the local area network. (medscape.com)
The innate immune system mainly comprises innate immune cells (macrophages: neutrophils, dendritic cells) and complement factors. (biomedcentral.com)
When dendritic cells are activated by inflammatory cytokines such as LPSs and inflammatory cytokines produced by macrophages, they present fragments of pathogens digested intracellularly to T cells and induce the activation of antigen-specific T cells. (biomedcentral.com)
G-CSF is a glycoprotein produced by variety of cells including macrophages and endothelium, which is typically associated with the presence of infection or tissue damage. (businesssinc.com)
It induces cells such as macrophages to produce more G-CSF, which in turn triggers production of more granulocytes. (businesssinc.com)
Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)
In co-cultures of either the murine pre-B cell line J13, fetal liver cells, or adult peritoneal or bone marrow cells with ST2 mouse bone marrow stromal cells in the presence of granulocyte/macrophage colony-stimulating factor (GM-CSF), the development of CD5+ macrophages was demonstrated by immunohistochemical staining and flow cytometry. (jax.org)
Although CD5+ macrophages were not present in the peritoneal cavities of normal mice, approximately 30% of the peritoneal macrophages in viable motheaten (mev/mev) mice, deficient in SHP-1 protein tyrosine phosphatase, expressed cell surface CD5 and B220, markers for B cells. (jax.org)
These results indicate that GM-CSF, in combination with M-CSF, induces the development and differentiation of CD5+ macrophages in the peritoneal cavity, particularly in the omental milky spots of mice. (jax.org)
In the peritoneal cavity of GM-CSF-treated mice, the percentages of hematopoietic progenitor cells doubly positive for CD5 and CD34 or c-kit and of macrophage precursor cells doubly positive for CD5 and ER-MP58 or ER-MP20 were increased significantly during the development of CD5+ macrophages and CD5 B cells, suggesting that CD5+ macrophages and B cells may share a bipotential progenitor in vivo. (jax.org)
Takahashi K, Miyakawa K, Wynn AA, Nakayama KI, Myint YY, Naito M, Shultz LD, Tominaga A, Takatsu K. Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)

It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. (uchicago.edu)
Human Granulocyte-Colony-Stimulating Factor (G-CSF), a 20 kDa glycoprotein containing internal disulfide bonds, induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. (sydlabs.com)
G-CSF R is expressed in mature neutrophils, neutrophilic precursors, myeloid leukemia cells, and placenta. (rndsystems.com)
Granulocytes include basophils, eosinophils, and neutrophils. (orthopedicshealth.com)
Filgrastim is one of a class of colony-stimulating factors that does, indeed, stimulate the proliferation and differentiation of neutrophils. (orthopedicshealth.com)
It stimulates the survival, proliferation, differentiation and function of neutrophil granulocyte progenitor cells and mature neutrophils. (allindianpatents.com)
describes a novel colony stimulating factor (CSF) that has the ability to promote the differentiation and proliferation of human bone marrow cells to neutrophils, and a method to produce the same from a novel cell line which has been established from tumor cells in patients with oral cancer, The most published studies have used filgrastim as it was the first form of G-CSF to be approved. (allindianpatents.com)

The proliferation and differentiation of pluripotent stem cells give rise to progeny that can populate the entire immunologic and hematopoietic systems through committed progenitors of both the lymphoid and myeloid lineages. (medscape.com)
G-CSF is a glycoprotein that induces the proliferation and differentiation of neutrophil granulocytes. (businesssinc.com)
The regulation of haematopoiesis is dependent on glycoprotein growth factors which drive the proliferation and differentiation of progenitor cells. (sysmex.es)

We found a significantly lower expression of key autophagy- (ATG-) related genes in primary AML as compared to healthy granulocytes, an increased autophagic activity during all- trans retinoic acid- (ATRA-) induced neutrophil differentiation, and an impaired AML differentiation upon inhibition of ATG3, ATG4D, and ATG5. (hindawi.com)
These mutations typically led to a truncation in the cytoplasmic domain of the G-CSF R leading to maturation arrest of neutrophil precursors in the bone marrow and neutropenia in peripheral blood (2). (rndsystems.com)
Treatment with granulocyte colony-stimulating factor is used to stimulate neutrophil production and prevent bacterial infections after cancer chemotherapy and with severe chronic neutropenia. (msdmanuals.com)

Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia. (uchicago.edu)
The etiology of bone marrow failure (BMF) includes defective stem/progenitor cells and/or stroma/accessory cells/growth factors, as well as deficient nonspecific nutrients or, as in the case of acquired aplastic anemia, immune-mediated abnormalities. (medscape.com)
Inherited bone marrow failure syndromes (IBMFS) are usually the result of intrinsic stem cell/progenitor defects. (medscape.com)
In human acute myeloid leukemia (AML), current models suggest transformation creates leukemic stem cell (LSC) populations arrested at a progenitor-like stage expressing cell surface CD34. (ox.ac.uk)
This suggests a new refined model of the relationship between LSCs and normal hemopoiesis in which the nature of genetic/epigenetic changes determines the disordered transcriptional program, resulting in LSC differentiation arrest at stages that are most like either progenitor or precursor stages of hemopoiesis. (ox.ac.uk)
In addition to TAMs, solid tumors are also infiltrated by immunosuppressive, immature myeloid progenitor cells, commonly referred to as monocytic or polymorphonuclear myeloid-derived suppressor cells (M/PMN-MDSC) ( 11 - 13 ). (frontiersin.org)
Hematopoietic cells differentiate from progenitor cells under the influence of hematopoietic growth factors (HGFs). (wikilectures.eu)
CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
A pluripotent stem cell can generate more stem cells (self-renewal) or differentiate into lymphoid or myeloid stem cells, becoming committed progenitor cells/unipotent stem cells. (wikilectures.eu)
Interleukin-3, which promotes the proliferation of both pluripotent stem cells and unipotent progenitor cells. (wikilectures.eu)
There are other growth factors that only induce specific committed progenitor cells. (wikilectures.eu)
The progenitor cells progressively lose their ability to divide and finally become terminally-differentiated blood cells. (wikilectures.eu)
Using a fresh optical approach, our interactive haematopoiesis graphic illustrates this development from the pluripotent stem cell via progenitor and precursor cells in bone marrow, lymph nodes and thymus to the mature blood cells circulating in peripheral blood. (sysmex.es)
Immature haematopoietic precursors can be identified and quantified by fluorescence flow cytometry employed by the XN-Series and partly XN-L Series analysers and are expressed in the following parameters: nucleated red blood cells (NRBC), immature granulocytes (IG), reticulocytes, immature platelets (IPF) and haematopoietic progenitor cells (HPC). (sysmex.es)

In addition to supporting colony formation of granulocyte/macrophage progenitors, GM-CSF is a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. (neobiotechnologies.com)
CD34(-) LSCs have disordered global transcription profiles, but these profiles are enriched for transcriptional signatures of normal CD34(-) mature granulocyte-macrophage precursors, downstream of progenitors. (ox.ac.uk)
Granulocyte colony stimulating factor (G-CSF) is a 20 kDa glycoprotein cytokine that stimulates growth and development of granulocyte progenitors in the bone marrow (Nagata et al. (allindianpatents.com)

Effects of granulocyte/macrophage colony-stimulating factor on the de" by K Takahashi, K Miyakawa et al. (jax.org)

Although tumor-promoting functions have been attributed to other granulocytes, like eosinophils ( 17 ), basophils ( 18 ) and mast cells ( 19 ), further research is required to fully elucidate their role in cancer, as antitumoral roles have also been described ( 20 , 21 ). (frontiersin.org)
function of proliferative responses provoked in the induction cell products favor immediate type hypersensitivity reactions, phase of contact allergy, the murine local lymph node assay serving as growth and differentiation factors for mast cells and (LLNA), has been accepted as a stand-alone method for skin eosinophils, the cellular effectors of the clinical manifestations of sensitization testing (NIH, 1999). (cdc.gov)

We demonstrate that the inhibitory receptor LILRB1 (ILT2, LIR1, CD85j) is selectively up-regulated during DC differentiation from monocyte precursors in culture. (ashpublications.org)

Granulocyte Colony Stimulating Factor (G-CSF) is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. (rndsystems.com)

At the beginning of hematopoietic cell differentiation is the pluripotent stem cell , which differentiates into lymphoid, erythroid and myeloid precursor cells . (wikilectures.eu)
The pluripotent stem cell can develop into all types of blood cells by going through several steps to ultimately become a red blood cell, platelet, or white blood cell. (sysmex.es)

When overexpressed by transfection, NME3 suppressed granulocyte differentiation and induced apoptosis of myeloid precursor cells. (wikipedia.org)
Accelerated hematopoietic cell apoptosis has been demonstrated in virtually all IBMFS. (medscape.com)
Yet another group of genes associated with cancer formation regulates programmed cell death, or apoptosis. (the-scientist.com)
The importance of apoptosis is exemplified by the vertebrate adaptive immune system, in which B lymphocytes, as they differentiate from their precursor cells, rearrange the DNA of immunoglobulin genes to generate a vast number of potential antibodies. (the-scientist.com)
Flow cytometry was performed to evaluate the cell apoptosis levels. (biomedcentral.com)
Compared with using ATO alone, the combination of G-CSF with ATO induced the cell apoptosis more dramatically. (biomedcentral.com)
In an ex vivo model KNK437 was used as an inhibition model assay of HSP70, showed dose-dependent inhibition of cell growth and burst formation unit erythroid (BFU-E) in PV and ET, increased apoptosis in the erythroid lineage, and decreased pJAK2 signaling, as well as a specific siRNA for HSP70. (biomedcentral.com)
Overexpression of HSP70 can provide a selective survival advantage to tumor cells in part due to its ability to inhibit multiple pathways of cell death, including both intrinsic and extrinsic apoptosis. (biomedcentral.com)
Second, the rapid proliferation of these cells, along with a reduction in their ability to undergo programmed cell death (apoptosis), results in their accumulation in the bone marrow, the blood, and, frequently, the spleen and liver. (medscape.com)

Planned Granulocyte Colony-Stimulating Factor Adversely Impacts Survival after Allogeneic Hematopoietic Cell Transplantation Performed with Thymoglobulin for Myeloid Malignancy. (uchicago.edu)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase. (umbc.edu)

The future direction of the study of hematopoietic stem cells will probably make use of pluripotent stem cells to yield specific immune cell lineages and eventual clinical applications. (biomedcentral.com)

Interleukin-17 induces the secretion of G-CSF in epithelial, endothelial, and fibroblastic cells. (sydlabs.com)
IL-3 induces the differentiation of hematopoietic stem cells into myeloid precursor cells, such as erythrocyte, megakaryocyte, granulocyte, monocyte, and dendritic cells. (cellgs.com)

Interleukin-3 (IL-3) is a cytokine that is produced by activated T cells and mast cells. (cellgs.com)
The myeloid precursor cell differentiates into megakaryoblast (→ megakaryocyte → thrombocyte), myeloblast (→ promyelocyte → myelocyte → metamyelocyte → rod → segment), monoblast (→ monocyte → macrophage), eosinophiloblast (→ eosinophil), mast cells (mast cells), and basophilic granulocytes. (wikilectures.eu)

Dendritic cells (DCs) link innate and adaptive immunity, initiating and regulating effector cell responses. (ashpublications.org)
Dendritic cells (DCs) play pivotal roles in the initiation, regulation, and maintenance of immune responses. (ashpublications.org)
This role is fulfilled by specialized cells called dendritic cells. (biomedcentral.com)
OBJECTIVE: The role of plasmacytoid dendritic cells (PDCs) and type I interferons (IFNs) in rheumatoid arthritis (RA) remains a subject of controversy. (cnrs.fr)

The symptoms of this disorder come about as the result of interference in the production of granulocytes in the bone marrow. (orthopedicshealth.com)

These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)

Erythroid precursor cells differentiate into erythroblasts (→ reticulocyte → erythrocyte). (wikilectures.eu)
Erythroid precursor cell (proerythroblast) → erythroblast → reticulocyte → erythrocyte. (wikilectures.eu)

Non-metastatic cells 4, protein expressed in, also known as NME4, is a protein which in humans is encoded by the NME4 gene. (wikipedia.org)
The structure of the recombinant human G-CSF protein expressed in E. coli, such as filgrastim, differs slightly from those of the natural glycoprotein and the recombinant human G-CSF protein expressed in mammalian cells such as CHO cells. (sydlabs.com)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
What started as a series of microscopic observations in different animal model systems has since evolved into studies of gene expression and regulation, and subsequent protein-protein interactions, cell surface protein expression profiling, and functional mapping of cell fates. (biomedcentral.com)
The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. (dimabio.com)
GA-binding protein and p300 are essential components of a retinoic acid-induced enhanceosome in myeloid cells. (umassmed.edu)
Granulate Colony Stimulation Factor (G-CSF), also known as Colony Stimulating Factor 3 or CSF3 protein, is a granulocyte colony-stimulating factor that plays an essential role in the production of certain white blood cells commonly referred to as granulocytes. (businesssinc.com)
BDNF protein encourages the growth and maturation (differentiation) of new neurons and synapses. (businesssinc.com)
The term "What is BDNF" refers to the protein that promotes the growth and differentiation of new neurons in the hippocampus, cortex and basal forebrain. (businesssinc.com)
Different from the APL cells, most non-APL AML cells express low levels of the ATO transporter Aquaporin-9 (AQP9) protein, making them less sensitive to ATO treatment. (biomedcentral.com)
Biologic drugs are made by transferring the gene for a therapeutic protein into a bacterial or mammalian cell. (biotechprimer.com)
That production cell makes the protein that corresponds to the transferred gene. (biotechprimer.com)
The precise manufacturing conditions are considered proprietary because the process of growing cells influences the final structure of the protein. (biotechprimer.com)
Cell activation by G-CSF is mediated by a type I membrane protein belonging to the cytokine receptor superfamily. (rndsystems.com)
The present invention relates to a chimeric protein of recombinant human granulocyte colony stimulating factor comprising of hG-CSF fused to an affinity fusion tag at its amino terminus. (allindianpatents.com)
Through 2D-DIGE and mass spectrometry of granulocyte protein from 20 MPN samples, showed differential expression of HSP70 in PV and ET besides other 60 proteins. (biomedcentral.com)

This attachment initiates the differentiation and maturation of the stem cell so it can graduate to become a WBC. (biotechprimer.com)

A variety of drugs can cause acquired agranulocytosis and neutropenia by destroying special cells in the bone marrow that later mature and become granulocytes (precursors). (orthopedicshealth.com)
Patients with prolonged neutropenia after hematopoietic stem cell transplantation or chemotherapy and patients receiving broad-spectrum antibiotics and high doses of corticosteroids are predisposed to fungal infections. (msdmanuals.com)
First, the production of normal blood cells markedly decreases, which results in varying degrees of anemia , thrombocytopenia , and neutropenia . (medscape.com)

1 Activation of DCs through toll-like receptors (TLRs) for "infectious nonself" or other "danger" signals normally initiates a process of cellular differentiation resulting in "mature" DCs capable of stimulating T-cell and natural killer (NK)-cell responses. (ashpublications.org)
Recent studies have suggested a role for human leukocyte Ig-like receptors (LILRs, also known as ILT, LIR, or CD85) in regulating the function of myeloid cells, potentially implicating these molecules in the control of immune responses. (ashpublications.org)
Similar to bone-derived osteoclasts, MNC formed in long-term human bone marrow culture expressed osteoclast-specific antigens (detected by monoclonal antibodies 13c2 and 23c6) and did not express Fc receptors, T cell specific antigens, most myeloid antigens or mature macrophage antigens. (elsevierpure.com)
Granulate Colony Stimulation Factor molecules bind with their receptors on various types of blood cell precursors, promoting their development into mature granulocytes and stem cells. (businesssinc.com)
G-CSF beefs up the immune system when it binds to receptors on the precursor to WBCs, known as hematopoietic stem cells. (biotechprimer.com)

The first morphologically identifiable precursors are the proerythroblast (giving rise to the erythroblast), myeloblast, monoblast, lymphoblast and megakaryoblast (precursor of the megakaryocyte). (wikilectures.eu)

The lymphoid precursor cell differentiates into pre-T-lymphocytes (→ T-lymphocytes) and pre-B-lymphocytes (→ B-lymphocytes → plasmocytes). (wikilectures.eu)
3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
Lymphocytes, B and T cells, can respond selectively to thousands of non-self materials. (lu.se)

Hck also acts as a negative regulator of granulocyte colony-stimulating factor (G-CSF)-induced proliferation of granulocytic precursors, suggesting a possible role in the development of acute myeloid leukemia (AML). (umbc.edu)
Our data clearly suggest that granulocytic AML differentiation relies on noncanonical autophagy pathways and that restoring autophagic activity might be beneficial in differentiation therapies. (hindawi.com)
Each of these infectious diseases is designated by the major target cell: human monocytic ehrlichiosis is caused by Ehrlichia chaffeensis, and human granulocytic ehrlichiosis by an E. equi -like organism. (cdc.gov)

Septilin stimulates phagocytosis by macrophage activation, increases the polymorphonuclear cells and helps overcome infection. (generic-meds-store.com)
It stimulates the bone marrow to produce granulocytes and stem cells to release them into the bloodstream. (businesssinc.com)
Granulate Colony Stimulation Factor (G-CSF or GCSF) is a glycoprotein and member of the colony-stimulating factor superfamily that stimulates the bone marrow to produce granulocytes, stem cells, and other blood cells. (businesssinc.com)

Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. (umbc.edu)

EPO-secreting tumors EPO-secreting tumors Polycythemia Vera , such as renal cell carcinoma Renal cell carcinoma Renal cell carcinoma (RCC) is a tumor that arises from the lining of the renal tubular system within the renal cortex. (lecturio.com)
A definitive diagnosis was obtained after a needle biopsy of the liver metastases, showing poorly differentiated carcinoma with large-scale necrosis and strong positivity of immunostaining for HCG in tumor cells. (bvsalud.org)
Our understanding of the perturbation of normal cellular differentiation hierarchies to create tumor-propagating stem cell populations is incomplete. (ox.ac.uk)
Abnormal cell division is a hallmark of tumor cells. (the-scientist.com)
Despite the arsenal of defense strategies against foreign invaders, myeloid cells succumb to the instructions of an established tumor. (frontiersin.org)
In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression. (frontiersin.org)
Another myeloid population in the tumor microenvironment (TME) are DCs, that originate from different precursors and display various phenotypes, ranging from immunosuppressive monocyte-derived DCs (Mo-DCs) to immunocompetent cDC1 and cDC2 subsets ( 22 ). (frontiersin.org)
Nevertheless, the majority of scientific discoveries points toward a more tumor-supporting role for myeloid cells in the TME. (frontiersin.org)

However, it is unclear if these cells express similar surface antigens as expressed by authentic osteoclasts, since they form on plastic surfaces in the absence of bone. (elsevierpure.com)

Continuous ligation of LILRB1 modulated cellular differentiation, conferred a unique phenotype upon the resultant cells, induced a profound resistance to CD95-mediated cell death, and inhibited secretion of cytokines IL-10, IL-12p70, and TGF-β. (ashpublications.org)
Markers of myeloid cells are useful in the identification of different levels of cellular differentiation. (gemini-genomics.com)

Blood cell formation is the process in which stem cells differentiate into the red or white blood cells. (wikilectures.eu)
Haematopoiesis is the process by which uncommitted haematopoietic stem cells proliferate and differentiate into all the cellular components of the blood. (sysmex.es)

Description: Recognizes an unidentified antigen in the cytoplasm of mature granulocytes. (gemini-genomics.com)
Description: This antibody recognizes an unidentified antigen in the cytoplasm of mature granulocytes and can be used as a granulocyte marker in normal tissues or inflammatory processes. (gemini-genomics.com)

But unlike mature precursors, LSCs express multiple normal stem cell transcriptional regulators previously implicated in LSC function. (ox.ac.uk)

For example, normal stroma, the connective material that supports the cells of a tissue, appears to inhibit cancer growth. (the-scientist.com)
Other drugs that interfere with, or inhibit, granulocyte colony formation may induce agranulocytosis. (orthopedicshealth.com)

This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. (dimabio.com)

The normal function of the proteins expressed by these genes is to recognize superfluous, damaged, aged, or aberrant cells that must be eliminated. (the-scientist.com)
Differentiation is stimulated by proteins called differentiation inducers . (wikilectures.eu)

Acute myeloid leukemia is an aggressive malignancy characterized by uncontrolled proliferation and accumulation of immature myeloid precursor cells in the bone marrow [ 1 ]. (biomedcentral.com)

Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage. (ox.ac.uk)
98% of cells are CD34(-), there are multiple, nonhierarchically arranged CD34(+) and CD34(-) LSC populations. (ox.ac.uk)
4 CD34 expression is historically related to hematopoietic cells and it is considered as the marker of HSCs. (bdbiosciences.com)
An accurate measurement of CD34 is critical for dose requirement protocols in stem cell transplantation. (bdbiosciences.com)
6 Fluorochrome-conjugated monoclonal antibodies directed against CD34 molecule can be used to identify CD34+ cells by flow cytometry. (bdbiosciences.com)

HGFs include erythropoietin , thrombopoietin , G-CSF (granulocyte colony-stimulating factor), GM-CSF (granulocyte-monocyte colony-stimulating factor). (wikilectures.eu)

Development Growth and Differentiation. (elsevierpure.com)
There are also growth factors for stem cells themselves, SCF (stem cell factor = c-kit-ligand) and FL (flt 3-ligand). (wikilectures.eu)
3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
The stem cells are stimulated to proliferate by growth factors e.g. (wikilectures.eu)

The BD ® Stem Cell Enumeration (SCE) Assay enumerates total viable CD34+ and CD45+ cells as a percentage of total viable leukocytes. (bdbiosciences.com)
7 Enumeration of the cell populations in this assay is obtained using either an automated or a manual method for gating and analysis. (bdbiosciences.com)

Granulocyte Colony-Stimulating Factor Use after Autologous Peripheral Blood Stem Cell Transplantation: Comparison of Two Practices. (uchicago.edu)
Haematopoietic stem cells, unlike embryonic stem cells, can be collected from the peripheral blood by apheresis after mobilisation. (sysmex.es)

Zarzio is similar to Amgen's (Thousand Oaks, CA) Neupogen and both of these medications are recombinant versions of the "go to" stimulator for white blood cell production-known as granulocyte-colony stimulating factor (G-CSF). (biotechprimer.com)
Another form of recombinant human G-CSF called lenograstim is synthesised in Chinese hamster ovary (CHO) cells. (allindianpatents.com)

Innate immune cells are also called phagocytes because they phagocytose when they recognize foreign substances such as lipopolysaccharides (LPSs). (biomedcentral.com)

3-5 LILRs are encoded by a set of genes within the leukocyte receptor cluster on chromosome 19q13.4, adjacent to the killer Ig-like receptor ( KIR ) genes that are responsible for controlling NK- and CD8 T-cell survival and effector functions. (ashpublications.org)
Autophagy is an intracellular degradation system that ensures a dynamic recycling of a variety of building blocks required for self-renewal, homeostasis, and cell survival under stress. (hindawi.com)
Basal macroautophagy (thereafter referred to as autophagy), a catabolic recycling system in cells, is key to maintaining cellular homeostasis and survival. (hindawi.com)
Furthermore, activation of autophagy allows to extend cell survival when exposed to different types of stressors such as starvation or cytotoxic drugs. (hindawi.com)
While the importance of autophagy for cell homeostasis and survival has long been appreciated, its role in tumorigenesis and cancer progression is still developing [ 10 , 11 ]. (hindawi.com)

SPM250 Ab reacts with early precursor and mature forms of human myeloid cells. (gemini-genomics.com)
Clone BM-2 mAb reacts with early precursor and mature forms of human myeloid cells. (gemini-genomics.com)

MNC also reacted with the monoclonal antibody My11, which is present on CFU-GM, the granulocyte-macrophage colony-forming cell, the probable precursor for MNC. (elsevierpure.com)
Septilin augments granulocyte-macrophage differentiation, natural killer cell activity and antibody-dependent cytotoxicity. (generic-meds-store.com)
Septilin's stimulatory effect on the humoral immunity increases the antibody-forming cells, thereby enhancing the secretion of antibodies into the circulation. (generic-meds-store.com)
The granulocyte marker antibody shows no reactivity with any other cell type in human tissues. (gemini-genomics.com)
It builds up resistance to disease and helps prevent reinfection, augments granulocyte-macrophage differentiation, natural killer cell activity and antibody-dependent cell cytotoxicity. (1001pills.com)
Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. (frontiersin.org)
1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)
3) T cell deficiencies result usually in combined immunodeficiencies (CIDs), where both T cells and antibody production are defective. (lu.se)

Myelodysplastic syndrome and acute myeloid leukemia after receipt of granulocyte colony-stimulating factors in older patients with non-Hodgkin lymphoma. (uchicago.edu)
3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
Symptoms may vary from chronic symptoms like retinopathy, CKD, hematopoietic ulcers to severe acute complaints like "Sickle Cell Crisis" triggered by dehydration, infections, acidosis and other obscure reasons. (atomictherapy.org)
We used primary acute myeloid leukemia (AML) samples and human AML cell lines to investigate the regulatory mechanisms of autophagy and its role in AML differentiation. (hindawi.com)
In rare cases of acute acquired agranulocytosis, destructive action of certain white blood cell antibodies (leukocyte isoantibodies) may be induced by certain drugs such as phenylbutazone, gold salts, sulfapyridine, aminopyrine, meralluride, and dipyrine. (orthopedicshealth.com)
Acute myelogenous leukemia (AML) is a malignant disease of the bone marrow in which hematopoietic precursors are arrested in an early stage of development. (medscape.com)

White blood cells, also called leukocytes, are any of the various colorless cells of the immune system that circulate mainly in the blood and lymph. (biotechprimer.com)
B-cells and selected T-cells migrate to the secondary lymphoid organs (lymph nodes, spleen, Mucosa-Associated Lymphoid Tissue, etc). (wikilectures.eu)

Hck is present in myeloid and lymphoid cells that play a role in the development of cancer. (umbc.edu)

Granulate Colony Stimulation Factor (G-CSF or GSCF) binds to GCSF receptor on bone marrow cells, triggering a cascade that releases granulocytes and stem cells into the bloodstream. (businesssinc.com)
G-CSF can be used to increase the numbers of circulating haemopoietic precursor cells which are then harvested by leucapheresis and used either as a supplement to or a substitute for aspirated bone marrow cells in autologous haemopoietic cell transplants. (allindianpatents.com)
The underlying pathophysiology in AML consists of a maturational arrest of bone marrow cells in the earliest stages of development. (medscape.com)

Patients with AML present with symptoms resulting from bone marrow failure, symptoms resulting from organ infiltration with leukemic cells, or both. (medscape.com)

Besides, the dominant types of infiltrating immune cells were macrophage and CD4+ T cells. (bvsalud.org)
Immune cells abundantly infiltrate tumors, creating a complex environment mediated by repetitive cycles of antitumor responses and immune evasion ( 1 ). (frontiersin.org)
2) T cell deficiencies affect the function in killing infected cells or helping other immune cells. (lu.se)

The first nm23 gene, nm23-H1 (NME1), was isolated based on its reduced expression in a highly metastatic murine melanoma cell line and was proposed to be a metastasis suppressing gene. (wikipedia.org)

Another characteristic is that senescent cells that accumulate in body tissues over time cause chronic inflammation through the secretion of proinflammatory cytokines, termed senescence-associated secretory phenotype. (biomedcentral.com)
Deficiencies are highly variable with regard to symptoms, phenotype, genotype, severity, etc, because many cells and molecules are required for both natural and adaptive immunity . (lu.se)

IL-3 also functions in the nervous system and is important during the B-1 cell regulation of chronic inflammatory diseases. (cellgs.com)
Hence, myeloid cells play a dual role in cancer as they can initiate antitumor responses and communicate with cells of the adaptive immune system, but also promote local inflammation leading to chronic cancer-associated inflammation ( 5 , 6 ). (frontiersin.org)

Anatomy23

Organisms3

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes27

Disciplines and Occupations1

Information Science3

Monocytes5

Macrophages19

Neutrophils7

Proliferation and differentiation3

Neutrophil3

Progenitor19

Progenitors3

Macrophage - Colo1

Eosinophils2

Monocyte precursors1

Neutrophilic granulocyte1

Pluripotent stem2

Apoptosis9

Hematopoietic cell3

Lineages1

Induces2

Mast cells2

Dendritic4

Production of granulocytes1

Endothelial2

Erythroid2

Protein16

Maturation1

Neutropenia3

Receptors5

Megakaryocyte1

Lymphocytes3

Granulocytic3

Stimulates3

Cytokine1

Tumor8

Antigens1

Cellular differentiation2

Differentiate2

Antigen2

Stem cell transcriptional1

Inhibit2

Modulates1

Proteins2

Immature myeloid1

CD345

Erythropoietin1

Growth4

Assay2

Peripheral blood2

Recombinant2

Innate immune cells1

Survival5

Mature2

Antibody8

Acute7

Lymph2

Lymphoid1

Bone marro3

Leukemic1

Immune cells3

Murine1

Phenotype2

Chronic2