Cell differentiation and bone growth differentiation factor 2. Medical search. Frequent questions

The signaling network in the niche establishes the baseline for self-renewal, fate determination, proliferation, and differentiation of intestinal stem cells. (wjgnet.com)
The self-renewal capacity, the balance of proliferation and differentiation are tightly controlled in the process of epithelial repair and regeneration. (wjgnet.com)
Promotes proliferation and differentiation of osteoprogenitor cells. (orthobullets.com)
Dysfunction in a myriad of overlapping signalling pathways can promote endothelial cell (EC) proliferation and differentiation, smooth muscle cell (SMC) proliferation, migration and vasoconstriction, pericyte proliferation, migration and differentiation, endothelial-to-mesenchymal transition, immune cell infiltration and extracellular matrix (ECM) remodelling in the pulmonary artery. (ersjournals.com)
Several growth factors such as fibroblast growth factor (FGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF), promote cell proliferation and differentiation. (medscape.com)
Redox homeostasis is crucial for dental pulp stem cell (DPSC) differentiation and mineralized matrix deposition, and interleukin-6 (IL-6) was found to be involved not only in immunomodulation but also in cell proliferation and differentiation. (uni-regensburg.de)
We will consider signalling mechanisms that integrate the complex and interdependent responsiveness to physiological mediators of osteoblast proliferation and differentiation. (umassmed.edu)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)

After differentiation, BMP4 and FGF2 treated cells generally produces higher amounts of osteogenic and chondrogenic differentiation than untreated stem cells. (wikipedia.org)
To enhance the osteogenic potential of stem cell sheet, we fabricated bone morphogenetic protein 2 ( BMP-2 ) gene-engineered cell sheet using a complex of polyethylenimine-alginate (PEI-al) nanocomposites plus human BMP-2 complementary(c)DNA plasmid, and studied its osteogenesis in vitro and in vivo. (dovepress.com)
The expression of osteogenesis-related gene was increased, which demonstrated that released BMP-2 could effectively induce the cell sheet osteogenic differentiation in vitro. (dovepress.com)
To further test the osteogenic potential of the cell sheet in vivo, enhanced green fluorescent protein or BMP-2-producing cell sheets were treated on the cranial bone defects. (dovepress.com)
Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
In their previous study, the researchers found that epimedin C could induce endothelial-like (but not osteogenic) differentiation of C3H/10T1/2 cells in vitro. (naturalnews.com)
Unique fibroblast growth factor receptor 2 ( FGFR2 ) mutations lead to an increase in the number of precursor cells that enter the osteogenic pathway. (medscape.com)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro, while inhibition of miR-103-3p showed the opposite results in NOR-MSCs. (techscience.com)
The miR-103-3p mimics may boost MDS-MSCs osteogenic differentiation while weakening lipid differentiation, thereby providing possible target for the treatment of MDS pathogenesis. (techscience.com)
In addition, their osteogenic differentiation potential was increased, and genes involved in cell adhesion, FGF-2 signalling, cell cycle, stemness, cell differentiation, and cell proliferation were upregulated, compared to that of the MSCs cultured on uncoated plates. (hindawi.com)
In this study, we found that BMP-13 inhibited the osteogenic differentiation of human bone marrow multipotent mesenchymal stromal cells (BM MSCs) in vitro. (ijbs.com)
In conclusion, BMP-13 inhibited osteogenic differentiation of MSCs, implying that functional mutations or deficiency of BMP-13 may allow excess bone formation. (ijbs.com)
The function of BMPs in bone remodelling and fracture repair is associated with the recruitment of stem cells from surrounding tissues and with effects on the osteogenic lineage commitment of these cells. (ijbs.com)
In addition to interacting with certain humoral factors that regulate bone homeostasis, VEGF can interact synergistically with osteogenic proteins, such as BMP-2, to promote bone formation and bone healing by enhancing cell recruitment, prolonging cell survival, and increasing angiogenesis. (springeropen.com)
Vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) are two key regulators of angiogenesis and osteogenesis and promote the endothelial and osteogenic differentiation of stem cells respectively. (springeropen.com)

In vitro methods for producing antibodies are amenable to large-scale production, meaning antibody availability is unlikely to become a limiting factor. (cellsignal.com)
To date, various studies have reported that cells isolated from the dental pulp of various animals can be induced to differentiate into cells of the odontoblastic phenotype by means of various chemicals, growth factors and signaling molecules both in vitro and in vivo ( reviewed in Nakashima and Akamine, 2005). (ispub.com)
2003). A previous in-vitro study on the role of GDF-5 in periodontal ligament cells has shown that exogenous GDF-5 promotes cell proliferation while suppressing the activity of alkaline phosphatase (ALP), which is closely related to tissue calcification and which is secreted during the formation of tissue calcifications. (ispub.com)
In vitro cultured OPCs showed more differentiation after incubation with BMSC-CM. Hes1 expression was found to be significantly increased by HD and decreased by BMSC or BMSC-CM. The change of Hes1 was found, however, independent of Notch1 activation, but dependent on TNFα/RelB signaling. (biomedcentral.com)
However, MSCs need to be expanded in vitro in order to obtain sufficient cells for clinical trials since they are extremely rare in various tissues. (hindawi.com)
Unlike embryonic stem cells, adult stem cells (MSCs) have a limited lifespan and stop proliferating during in vitro culture due to replicative senescence [ 8 ]. (hindawi.com)
In vitro differentiation induction of normal human periodontal ligament fibroblasts, HpdLF, into an osteoblast lineage was attempted and the changes in gene expression were examined. (jarde.jp)
These polymeric materials organise fibronectin (FN), an important protein of the extracellular matrix, and sequester rhBMP-2 in synergy with the integrin binding region to direct stem cell differentiation in vitro. (interface-online.org.uk)
The silk-fibroin-induced pacemaker cells exhibited functional and morphological features of genuine sinoatrial-node cardiomyocytes in vitro, and pacemaker cells generated via the injection of silk fibroin in the left ventricles of rats functioned as a surrogate in situ sinoatrial node. (biomed.news)
Thus, tissue loading in vivo resulted in increased TNFa, which increased PLF, which then induced anabolic bone formation, the latter results confirmed in vitro. (cdc.gov)

Promotes differentiation of mesenchymal cells into chondrocytes and osteoblasts. (orthobullets.com)
Promotes differentiation of osteoprogenitors into osteoblasts, influences skeletal pattern formation. (orthobullets.com)
Mitogenic for mesenchymal cells, chondrocytes, and osteoblasts. (orthobullets.com)
The AttraX surface technology, through its carefully defined and tightly controlled features at the submicron scale, drives the differentiation of mesenchymal stem cells into bone-forming osteoblasts without added growth factors. (nuvasive.com)
It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
Here we show that bone marrow endosteal SSCs are defined by fibroblast growth factor receptor 3 ( Fgfr3 ) and osteoblast-chondrocyte transitional (OCT) identities with some characteristics of bone osteoblasts and chondrocytes. (nature.com)
Therefore, Fgfr3 + endosteal SSCs are abundant in young bone marrow and provide a robust source of osteoblasts, contributing to both normal and aberrant osteogenesis. (nature.com)
Of note, we define OCT identities as a state with some characteristics of both osteoblasts and chondrocytes, instead of cell-type plasticity between osteoblasts and chondrocytes. (nature.com)
BMP2 is a cytokine and growth factor that stimulates the differentiation of myoblasts to osteoblasts. (naturalnews.com)
4) Are alterations in gene expression and cell phenotypic properties in transformed osteoblasts and osteosarcoma cells reflected by modifications in nuclear matrix proteins? (umassmed.edu)
Indeed, BMP-13 expression was absent from osteoblasts or newly formed osteocytes, rather BMP-13 was strongly detected in chondrocytes in a human osteophyte (bone spur) study [ 13 ]. (ijbs.com)
They regulate cell proliferation, differentiation, motility and survival from the embryonic phase until the adult phase and especially promote differentiation of myoblasts into osteoblasts and their maturation. (researchensemble.com)
The SMOC-1 protein also likely promotes the maturation (differentiation) of cells that build bones, called osteoblasts . (medlineplus.gov)

Bach, E.A. JAK/STAT signaling in stem cells and regeneration: From drosophila to vertebrates. (benthamscience.com)
The expression of Prx1 has been used as a marker to define the skeletal stem cells (SSCs) populations found within the bone marrow and periosteum that contribute to bone regeneration. (researchgate.net)
The use of osseous graft materials and guided bone regeneration have demonstrated enhancement of socket healing by potentially modifying the resorption process. (allenpress.com)
Regeneration of large bone defects is a common clinical problem. (dovepress.com)
Our results suggested that PEI-al nanocomposites efficiently deliver the BMP-2 gene to bone marrow mesenchymal stem cells and that BMP-2 gene-engineered cell sheet is an effective way for promoting bone regeneration. (dovepress.com)
Regeneration of bone remains an important clinical challenge because the regeneration potential of human bone appears to be limited. (dovepress.com)
It plays a dominant role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration (1, 2). (novusbio.com)
Yet it remains poorly understood how these factors can induce the various types of cells in the dental pulp to engage in a harmonized and coordinated process of dentin regeneration. (ispub.com)
Stem cell biology is an important study field to understand tissue regeneration and the implementation of regenerative medicine 11 . (bvsalud.org)
They found that this bioactive plant component is a good promoter of vascularization and may have potential applications in bone regeneration. (naturalnews.com)
BMPs were originally identified because of their ability to induce endochondral bone formation and are important regulators of key events in the process of bone formation during embryogenesis, postnatal growth, remodelling and regeneration of the skeleton [ 1 , 2 , 3 ]. (ijbs.com)
Following injury or disease, an organism undergoes a variety of (natural or induced) processes to direct cells, tissues and cellular processes towards healing and eventually regeneration. (interface-online.org.uk)
In the future, modulation of TrkA signaling may represent a potent means to prevent the trauma-induced heterotopic bone formation and improve tissue regeneration. (nih.gov)
Herein, the self-activating implants modified with hydroxyapatite (HA)/MoS2 coating are designed to prevent Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) infections and accelerate bone regeneration simultaneously. (biomed.news)
Bone repair or regeneration, like bone development, requires the concerted activity of several different cellular pathways. (springeropen.com)
The incorporation of osteoinductive factors into scaffolds is usually required to promote sufficient bone regeneration (Egri & Eczacioglu, 2017 ). (springeropen.com)
Specific growth factors play important roles in the regeneration process of different tissues. (springeropen.com)
These two factors synergistically enhance bone regeneration (Tatullo et al. (springeropen.com)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)

Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. (wikipedia.org)
BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. (wikipedia.org)
Conclusion: For the protection of stem cells against apoptosis, different pathways, namely Phosphoinositide 3-Kinase (PI3K/AKT), Hypoxia-Inducible Factor (HIF1), Mitogen-Activated Protein Kinases (MAPK) and Hippo, are discussed. (benthamscience.com)
Aifantis, I. Regulation of stem cell function by protein ubiquitylation. (benthamscience.com)
Prior studies of acute phosphate restriction during the endochondral phase of fracture healing showed delayed chondrocyte differentiation was mechanistically linked to decreased bone morphogenetic protein signaling. (researchgate.net)
Recombinant human bone morphogenetic protein 2 (rh. (researchgate.net)
Recombinant human bone morphogenetic protein 2 (rhBMP2) is a. (researchgate.net)
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. (novusbio.com)
Growth/differentiation factor-5 (GDF-5) belongs to the bone morphogenetic protein (BMP) family, which is expressed in dental pulp tissues. (ispub.com)
Growth/differentiation factor-5 (GDF-5) is a member of the bone morphogenetic protein (BMP) family, which is a subgroup of the transforming growth factor- (TGF-) superfamily. (ispub.com)
Along with other BMPs, including BMP-2, -4 and -7, which are well known as potent osteoinductive growth factors, GDF-5 plays important roles in the development of bones, cartilage and tendons, as evidenced by the tendency for the gene and protein expression levels of GDF-5 to increase over time in these tissues. (ispub.com)
Since the researchers already knew that vasculogenesis plays a pivotal role in bone formation, they used a bone morphogenetic protein 2 (BMP2)-induced ectopic bone formation model and mice 4T1 breast cancer cells co-implanted with luciferase-labeled C3H/10T1/2 cells (4T1 + C3H/10T1/2-Luc) model for their study. (naturalnews.com)
Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase . (wikidoc.org)
BMPR2 is expressed on both human and animal granulosa cells, and is a crucial receptor for bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF 9). (wikidoc.org)
[3] However, BMPR2 can't bind BMP15 and GDF9 without the assistance of bone morphogenetic protein receptor 1B (BMPR1B) and transforming growth factor β receptor 1 (TGFβR1) respectively. (wikidoc.org)
Prostaglandin-2 (PGE2) and IL-6 secretion was monitored by ELISA assays, and protein expression levels were quantified by Western blotting. (uni-regensburg.de)
They began by examining populations of seemingly identical blood stem cells, and found that a cell marker of "stemness," a protein called Sca-1, was actually present in highly variable amounts from cell to cell -- in fact, they found a 1,000-fold range. (sciencedaily.com)
The expression of bone differentiation markers such as alkaline phosphatase, type 1 collagen, insulin-like growth factor (IGF) 1, IGF2, bone morphogenic protein 2 (BMP2) and osteocalcin at 3 weeks after induction were increased compared with pre-induction. (jarde.jp)
Bone morphogenetic protein-13 (BMP-13) plays an important role in skeletal development. (ijbs.com)
BMP-13, also known as growth differentiation factor 6 (GDF6) and cartilage-derived morphogenetic protein-2 (CDMP-2), was first identified and isolated as a component of bovine cartilage [ 5 ]. (ijbs.com)
The full length protein consists of four modulesModule I shares partial identity with the N-terminal part of the Insulin-like Growth Factor Binding Proteins (IGFBPs). (neuromics.com)
Module IV resembles the CT domain of several extracellular protein including, Von Willebrand's factor and mucins. (neuromics.com)
WNT, fibroblast growth factor (FGF), Notch, Hedgehog, and transforming growth factor β/bone morphogenetic protein signaling network are implicated in the maintenance of tissue homeostasis by regulating self-renewal of normal stem cells as well as proliferation or differentiation of progenitor (transit-amplifying) cells. (aacrjournals.org)
Herein, we investigated the effect of dovitinib on human recombinant bone morphogenetic protein (BMP)-2-induced osteoblast differentiation in a cell culture model. (molcells.org)
Dovitinib also stimulated the translocation of phosphorylated Smad1/5/8 into the nucleus and phosphorylation of mitogen-activated protein kinases, including ERK1/2 and p38. (molcells.org)
Thermoresponsive coatings of poly( em N /em -isopropylacrylamide- em co /em -DMAEMA)/cellulose sulfate (PNIPAM-DMAEMA/CS) complexes are reported eluting bone-morphogenetic-protein-2 (BMP-2) on demand relevant for implant assisted local bone healing. (researchensemble.com)
Finally, the PNIPAM-DMAEMA/CS coatings were loaded with BMP-2 and model protein papain (PAP). (researchensemble.com)
Time dependent FTIR spectroscopic measurements showed, that for T = 37 C there was a relative protein release of 30% for PAP and 10% for BMP-2 after 24 h, which did not increase further. (researchensemble.com)
Heating to T = 42 C for PAP and to 47 C for BMP-2 further secondary protein release of PSI-7977 supplier 20% after 24 h was found, respectively, interesting for clinical applications. (researchensemble.com)
strong class="kwd-title" Keywords: bone healing, protein delivery, polyelectrolyte complex, thermoresponsive polymers, bone morphogenetic protein 2 1. (researchensemble.com)
The molecular structure of BMPs like BMP-2 is known from protein crystallography [7]. (researchensemble.com)
BMP-2 has a molecular weight around 30.000 g/mol, possesses a high content of -helix/-sheet and an isoelectric point of IEP = 8.5, classifying it as a basic cationic protein at the physiological pH = 7.0. (researchensemble.com)
Three topics are focused in this report, which are colloidal properties and VPT behavior of PNIPAM-DMAEMA/CS in the bulk dispersion (i), interfacial properties and VPT behavior of the PNIPAM-DMAEMA/CS coating (ii) and thermoinducable release of model protein papain and biomedically relevant BMP-2 out of this coating (iii). (researchensemble.com)
The bone morphogenetic protein (BMP-2) family of growth factors plays critical roles in bone formation. (springeropen.com)
Although VEGF can control hypertrophic cartilage structure and vascularity within the developing growth plate (Gittens & Uludage, 2001 ), BMP-2 pro-protein contains four glycosylation sites. (springeropen.com)
IL-5 is a homodimeric, disulphide-linked protein produced by T-cells. (biolegend.com)
This protein is found in basement membranes, which are thin, sheet-like structures that support cells in many tissues and help anchor cells to one another during embryonic development. (medlineplus.gov)
The SMOC-1 protein attaches (binds) to many different proteins and is thought to regulate molecules called growth factors that stimulate the growth and development of tissues throughout the body. (medlineplus.gov)
10%. In the remaining 10% of children with lecular weight protein found on the surface nephrotic syndrome, it is largely mediated of all nucleated cells which synthesize it. (who.int)

BMP4 stimulates differentiation of overlying ectodermal tissue. (wikipedia.org)
citation needed] BMP4 also limits the extent to which neural differentiation in Xenopus embryos occurs by inducing epidermis formation rather than neural tissue. (wikipedia.org)
BMP4 also plays important roles in adipose tissue: it is essential for white adipogenesis, and promotes adipocyte differentiation. (wikipedia.org)
Background: Stem cells are of two types: embryonic and adult stem cells and they act as a repair system by replenishing body tissue. (benthamscience.com)
Discussion: Activation of the PI3K/AKT pathway decreases the concentration of apoptotic factors, while the HIF pathway protects stem cells against the micro-environment of tissue (hypoxia). (benthamscience.com)
Ramalingam, M. Surface functionalization of nanobiomaterials for application in stem cell culture, tissue engineering, and regenerative medicine. (benthamscience.com)
Where polyclonal antibodies are purified directly from the serum of the immunized host, and monoclonals are purified from either hybridoma-derived tissue culture supernatant or ascites, recombinant antibodies are instead purified from the tissue culture supernatants of transfected host cell lines. (cellsignal.com)
Recently, stem cell sheet has been an emerging strategy in bone tissue engineering. (dovepress.com)
2 , 3 Bone tissue engineering (BTE) attempts to solve the referred problems mentioned. (dovepress.com)
These results indicate that, although GDF-5 may have no effect on cell proliferation in isolated dental pulp tissue, it could promote odontoblast differentiation. (ispub.com)
In the body, vascularization is important for the efficient delivery of oxygen and nutrients to support tissue healing and bone formation. (naturalnews.com)
Finally, the researchers reported that the mRNA levels of endothelial markers - namely, the platelet endothelial adhesive factor-1 (CD31), the endothelial cell-specific molecule-1 (ESM-1), and the vascular von Willebrand factor (vWF) in mouse 4T1 mammary tumor tissue - significantly increased after epimedin C treatment. (naturalnews.com)
The principal theme of this prospect will be the contribution of nuclear structure to the regulation of gene expression as functionally related to development and maintenance of the osteoblast phenotype during establishment of bone tissue-like organization. (umassmed.edu)
There is a striking representation of nuclear matrix proteins unique to cells, tissues as well as developmental stages of differentiation, and tissue organization. (umassmed.edu)
It is realistic to consider the utilization of nuclear matrix proteins for targeting regions of cell nuclei and specific genomic domains on the basis of developmental phenotypic properties or tissue pathology. (umassmed.edu)
MSCs can easily be obtained from various human tissue sources such as the bone marrow, cord blood, placenta, and adipose [ 2 - 5 ]. (hindawi.com)
The clinical application of MSCs to tissue engineering has been introduced due to their numerous advantages including high expansion potential and extensive differentiation potential [ 6 , 7 ]. (hindawi.com)
Connective Tissue Growth Factor belongs to the CCN family of proteins. (neuromics.com)
The CCN family presently consists of six members in human also known as: Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), Nov (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). (neuromics.com)
WNT signals are transduced to the canonical pathway for cell fate determination, and to the noncanonical pathway for control of cell movement and tissue polarity. (aacrjournals.org)
In to the previously listed EDAC/PNIPAM-AA coatings, the reduced molecular anionic medication zoledronate (ZOL) for bone tissue healing was packed and an elevated ZOL elution with an increase of temperature was proven [1]. (researchensemble.com)
This locating is pertinent for the functionalization of bone tissue substituting components (BSM) with medication delivery systems working on-demand, i.e., induced by an exterior stimulus, which is pertinent for implant aided local bone tissue healing. (researchensemble.com)
rhBMP-2 is a powerful growth factor that is essential in tissue morphogenesis and is utilised to promote bone growth in trauma, spine and maxillofacial clinical applications. (interface-online.org.uk)
Recently, we observed that NGF (Nerve growth factor)-responsive TrkA (Tropomyosin receptor kinase A)-expressing nerves invade sites of soft-tissue trauma, and this is a necessary feature for heterotopic bone formation at sites of injury. (nih.gov)
Within the body, cells of the skin, gut, and blood, among others come to maturation, function for a time and then expire to be replaced by a continuous stream of cells which renew the tissue. (case.edu)
In every tissue in which this rejuvenation process occurs, a source exists which gives rise to these differentiated cells. (case.edu)
Bone is a highly vascularized tissue in which blood vessels and bone cells interact to maintain skeletal integrity (Gemini et al. (springeropen.com)
In this study, we investigated the relationship between inflammatory cytokines and matricellular proteins (Periostin-like-factor, PLF, and connective tissue growth factor, CTGF) using our model. (cdc.gov)

Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. (wikipedia.org)
It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. (wikipedia.org)
Bone morphogenetic proteins are known to stimulate bone formation in adult animals. (wikipedia.org)
Transforming growth factor family proteins like TGFß1 can oppose these effects. (medscape.com)
It binds Bone morphogenetic proteins , members of the TGF beta superfamily of ligands, which are involved in paracrine signalling . (wikidoc.org)
Huang and Chang then looked at the proteins GATA1 and PU.1, transcription factors that normally favor differentiation into red and white blood cells, respectively. (sciencedaily.com)
Findings are presented which are consistent with involvement of nuclear structure in gene regulatory mechanisms which support osteoblast differentiation by addressing four principal questions: 1) Does the representation of nuclear matrix proteins reflect the developmental stage-specific requirements for modifications in transcription during osteoblast differentiation? (umassmed.edu)
2) Are developmental stage-specific transcription factors components of nuclear matrix proteins? (umassmed.edu)
Together with selective association of regulatory molecules with the nuclear matrix in a growth and differentiation-specific manner, there is a potential for application of nuclear matrix proteins in tumor diagnosis, assessment of tumor progression, and prognosis of therapies where properties of the transformed state of cells is modified. (umassmed.edu)
This kit contains the following optimized proteins and reagents to drive the efficient differentiation of mouse monocytes into dendritic cells. (rndsystems.com)
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily, which includes the families of TGF-βs, BMPs, activins and inhibins. (ijbs.com)
The CCN genes encode secreted proteins associated with the Extracellular Matrix (ECM) and cell membrane. (neuromics.com)
CCN proteins are matricellular proteins which are involved in the regulation of various cellular functions including: proliferation, differentiation, survival, adhesion and migration. (neuromics.com)
Herein we wish to visit further and extend this development from charged low molecular drugs to higher molecular functional proteins used for bone healing. (researchensemble.com)
Among those proteins certain growth factors like bone morphogenetic proteins (BMP) have drawn considerable interest [5]. (researchensemble.com)
Expression of particular growth factors such as vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMPs) during the healing suggests a possible role for these secreted factors in bone repair. (springeropen.com)

10 MPa) stimulates chondrogenic differentiation of mesenchymal stem cells, but mechanotransduction mechanisms are not well understood. (openorthopaedicsjournal.com)

Although dovitinib can bind several kinases at nanomolar concentrations, there are no reports relating to osteoporosis or osteoblast differentiation. (molcells.org)
Dovitinib enhanced the BMP-2-induced alkaline phosphatase (ALP) induction, which is a representative marker of osteoblast differentiation. (molcells.org)
Our results suggest that dovitinib has a potent stimulating effect on BMP-2-induced osteoblast differentiation and this existing drug has potential for repositioning in the treatment of bone-related disorders. (molcells.org)

The efficiency of transplanted stem cells reduces due to conditions like hypoxia, inflammation, nutrient deprivation, immunogenicity, extracellular matrix loss on delivery and mechanical stress. (benthamscience.com)
Both exogenous (inflammation, chemoradiotherapy, and diet) and endogenous factors (mitochondrial dysfunction, extracellular matrix, and enteric nervous system) have vital effects on stem cell fate modulation. (wjgnet.com)
It is a complex and dynamic process to form a continuous construct via the cells' adhesion, proliferation, differentiation, and extracellular matrix (ECM) deposition on a scaffold. (dovepress.com)
WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
The extracellular matrix (ECM) provides structural and biochemical support to the surrounding cells, and it has been used as a coating substrate for cell culture. (hindawi.com)

In this study, we report a novel population of SSCs with osteoblast-chondrocyte transitional (OCT) identities in the bone marrow endosteal space, which highly expresses Fgfr3 and contributes to both normal and aberrant osteogenesis. (nature.com)
Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)
The researchers found that epimedin C treatment significantly increased the bone weight and blood perfusion of mice in the BMP2-induced ectopic osteogenesis model. (naturalnews.com)
BMPs are involved in a host of cellular functions including osteogenesis , cell growth and cell differentiation . (wikidoc.org)
Osteogenesis and angiogenesis are two closely correlated processes during bone growth, development, remodeling, and repair. (springeropen.com)

Tooth formation relies on BMP4 expression, which induces Msx 1 and 2. (wikipedia.org)
Recombinant human/mouse/rat BMP-2 (355-BM) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. (novusbio.com)
BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth, and bone and cartilage repair (6, 7). (novusbio.com)
Studies have demonstrated that severe oligohydramnios decreased lung cell size, alters cell shape and may also negatively affect Type I cell differentiation which ultimately induces pulmonary hypoplasia. (medscape.com)
BMP2 also induces the formation of cartilage and bones. (naturalnews.com)
IL-6 constitutes a major growth factor for myeloma and plasma cells, induces immunoglobulin production, and is an active factor in B-cell differentiation ( 4 , 5 ). (cdc.gov)
Specifically, oxidative stress by reactive oxygen species (ROS) is the main extrinsic factor that induces senescence [ 12 ]. (hindawi.com)
In the presence of testosterone , FSH stimulates the Sertoli cells and induces spermatogenesis. (msdmanuals.com)

stimulates production of Type II collagen and proteoglycans by mesenchymal cells. (orthobullets.com)
Conversely, when stem cells were exposed to granulocyte--macrophage colony-stimulating factor, which stimulates white blood cell formation, those that were highest in Sca-1 were the most likely to become white cells. (sciencedaily.com)

These Fgfr3-creER -marked endosteal stromal cells contribute to a stem cell fraction in young stages, which is later replaced by Lepr-cre -marked stromal cells in adult stages. (nature.com)
These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)

Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. (novusbio.com)
The up-regulation of IGF1 or IGF2 may be due to activation of pathways for the induction of alkaline phosphatase and type 1 collagen, and the differentiation of HpdLF into an osteoblast lineage. (jarde.jp)

the products of the GH-IGF-1 system induce proliferation without maturation of the growth plate and thus induce linear skeletal growth. (orthobullets.com)
To date, various studies have reported that BMP-family growth factors can induce cells isolated from dental pulp tissues to differentiate into odontoblasts. (ispub.com)
Kit-derived Mature Mouse Dendritic Cells Induce Proliferation of Allogeneic T Cells. (rndsystems.com)
The abnormal bone structure and location induce pain and loss of mobility. (nih.gov)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)

The conventional view of how stem cells differentiate assumes that cells are "instructed" to progress along prescribed signaling pathways. (sciencedaily.com)
A new study suggests that the conventional view, which assumes that cells are "instructed" to progress along prescribed signaling pathways, is too simplistic. (sciencedaily.com)
These processes generally involve growth factors (GFs), substances that control cell function through the activation of specific signalling pathways and that are capable of stimulating cellular growth, proliferation, and cellular differentiation. (interface-online.org.uk)
Following isolation and by mitotically expanding their numbers in culture, we can drive these cells down specific and different developmental pathways with emphasis on cartilage and bone. (case.edu)
A committee of experts, initially sponsored by the World Health Organization (WHO), meets every 2 years with the goal to classify the group of primary immunodeficiency diseases according to current understanding of the pathways that become defective in the immune system. (medscape.com)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

This review provides a brief history of mesenchymal stem cell (MSCs) and provides an updated view of the many stem/progenitor cell populations contributing to fracture repair. (researchgate.net)
Heterotopic ossification (HO) is a dynamic, complex pathologic process that often occurs after severe polytrauma trauma, resulting in an abnormal mesenchymal stem cell differentiation leading to ectopic bone growth in soft-tissues including tendons, ligaments, and muscles. (nih.gov)
The emphasis of our studies is to develop and refine the technology necessary to isolate one of these rare stem cells, the mesenchymal stem cell (MSC). (case.edu)

Based on these results, the researchers concluded that epimedin C effectively promotes vascularization both in the BMP2-dependent bone formation model and in the 4T1 mammary tumor-bearing model by inducing the endothelial-like differentiation of C3H/10T1/2 in vivo. (naturalnews.com)
Blood stem cells with low levels of Sca-1 differentiated into red blood cell progenitors seven times more often than cells high in Sca-1 when exposed to erythropoietin, a growth factor that promotes red blood cell production. (sciencedaily.com)
Meanwhile, this coating promotes the osteoblastic differentiation of mesenchymal stem cells by altering the potentials of cell membrane and mitochondrial membrane. (biomed.news)

the action of the thyroid hormone axis is via an active metabolite that enters target cells and signals a nuclear receptor to stimulate both proliferation and maturation of the growth plate. (orthobullets.com)
Comparisons with other BMPs known for their ability to stimulate bone growth have suggested that BMP-13 is not strongly osteo-inductive [ 9 , 10 , 11 , 12 ]. (ijbs.com)
In fact, VEGF has been shown to stimulate bone healing in animal models. (springeropen.com)
IL-5 has been shown to promote the growth of immature hematopoietic BFU-E progenitors, stimulate the activation and differentiation of eosinophils, and promote the generation of cytotoxic lymphocytes. (biolegend.com)

Led by Sui Huang, MD, PhD, a Visiting Associate Professor in the Children's Hospital Boston Vascular Biology Program (now also on the faculty of the University of Calgary), and Hannah Chang, an MD/PhD student in Children's Vascular Biology Program, the researchers examined how blood stem cells "decide" to become white blood cell progenitors or red blood cell progenitors. (sciencedaily.com)
During adulthood, they are implicated in wound healing, bone fracture repair, and pathologies such as: fibrosis, vascular ailments and tumorigenesis. (neuromics.com)
In summary, these studies further link injury site hyper-innervation with increased vascular ingrowth and ultimately heterotopic bone after trauma. (nih.gov)
Here we show that the exposure of rat quiescent ventricular cardiomyocytes to a silk-fibroin hydrogel activates the direct conversion of the quiescent cardiomyocytes to pacemaker cardiomyocytes by inducing the ectopic expression of the vascular endothelial cell-adhesion glycoprotein cadherin. (biomed.news)
Vascular endothelial growth factor (VEGF) is an essential mediator during the process of angiogenesis. (springeropen.com)
One such pathway, angiogenesis mediated by vascular endothelial growth factor (VEGF), is important for the coupling of cartilage resorption and mineralized bone formation during endochondral ossification in bone development (Huang et al. (springeropen.com)

Mammalian cell lines are most commonly used for recombinant antibody production, although cell lines of bacterial, yeast, or insect origin are also suitable. (cellsignal.com)
In this study, we assayed the effect of exogenous mouse recombinant GDF-5 on cell proliferation of dental pulp cells and determined the expression levels of odontoblast differentiation marker genes in the cells of isolated mouse dental pulp tissues in the presence of GDF-5. (ispub.com)
Opened or reconstituted Mouse Dendritic Cell Base Media, Recombinant Mouse GM-CSF, Recombinant Mouse IL-4, or Recombinant Human TNF-alpha should be stored at 2-8 ° C under sterile conditions for up to 30 days or at -20 ° C to -70 ° C in a manual defrost freezer for up to 3 months. (rndsystems.com)
Recombinant human BMP-2 and BMP-7 are used clinically to augment bone formation in spinal fusion and many other applications in which bone induction is desired [ 4 ]. (ijbs.com)

1 The obstacles of current bone substitutes include the limited amounts of donor bone, the bone resorption of autografts, the risk of disease transmission and graft rejection of allografts, and the shortage of osteoinductive property for synthetic grafts. (dovepress.com)
Traditional BTE involves three-dimensional biodegradable scaffolds, stem cells, and osteoinductive growth factors. (dovepress.com)
Osteoinductive ceramics as a synthetic alternative to autologous bone grafting. (nuvasive.com)
Since around 1970 BMPs, which belong to the TGF- class, have been identified as essential molecules for the de-novo formation of animal bones [6] and as the strongest known osteoinductive factor. (researchensemble.com)

This particular family member plays an important role in the onset of endochondral bone formation in humans. (wikipedia.org)

Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)

Somites are required for the development of cartilage, bone, dermis on the dorsal side of the body, thoracic muscles and muscles within limbs. (wikipedia.org)
BMP4 is important for bone and cartilage metabolism. (wikipedia.org)
In addition, development and genetic studies have shown that GDF-5 null mutation or transgenic mice exhibit abnormal growth patterns or overgrowth of limbs, long bones, cartilage, joints and digits (Storm et al. (ispub.com)
They are expressed in derivatives of the three embryonic sheets and are implicated in the development of kidney, nervous system, muscle, bone marrow, cartilage and bone. (neuromics.com)
Next, TrkA agonism led to injury site hyper-innervation, more brisk expression of cartilage antigens within the injured tendon, and a shift from FGF to TGFβ signaling activity among injury site cells. (nih.gov)
The MSC gives rise to bone-forming cells, cartilage-forming cells and cells of tendon, ligament fat, and dermis, as well as various connective tissues including the stroma of marrow. (case.edu)
These effects of VEGF lead to enhanced cartilage formation, accelerated resorption, and improved bone formation (Hu & Olsen, 2016 ). (springeropen.com)

Since the transcriptome is a representation of the phenome, we hypothesized that both sex and sex specific temporal, transcriptomic differences in bone tissues over an 18‐month period would be informative to the underlying molecular proce. (researchgate.net)
Nevertheless, the effect of GDF-5 on odontoblast differentiation from dental pulp tissues remains unknown. (ispub.com)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
We have previously developed a voluntary rat model of highly repetitive reaching that provides an opportunity to study effects of non-weight bearing muscular loads on bone and mechanisms of naturally occurring inflammation on upper limb tissues in vivo. (cdc.gov)

BMP4, in conjunction with FGF2, promote differentiation of stem cells to mesodermal lineages. (wikipedia.org)
C3H/10T1/2 is a clonal mouse embryo line used in the developmental determination of vertebrate stem cell lineages and their subsequent differentiation. (naturalnews.com)
C3H/10T1/2 cells can be induced to differentiate into multiple stem cell lineages. (naturalnews.com)
The findings also help explain why the process of differentiating stem cells into specific lineages in the laboratory has been highly inefficient. (sciencedaily.com)
The differentiation of mesenchymal stem cells (MSCs) into multiple cell lineages can be exploited as an attractive strategy for cell-based therapy and regenerative medicine [ 1 ]. (hindawi.com)

The discovery of this new class of SSCs is based on the conjunction of evidence from unbiased single-cell molecular profiling and functional dissection of the BMSC lineage hierarchy using in vivo cell lineage analysis. (nature.com)
Why Differentiate Dendritic Cells ex vivo ? (rndsystems.com)
We demonstrate that the system allows for mitochondria-specific, correlated imaging of ATP and GSH in living cells and in vivo. (biomed.news)

While both processes result in new blood vessel formation, vasculogenesis occurs mainly during embryonic development and is facilitated by EPCs, while angiogenesis takes place via "sprouting" of endothelial cells , which allows new blood vessels to take shape from already existing blood vessels. (naturalnews.com)
It functions by promoting the survival of pulmonary arterial endothelial cells, therefore preventing arterial damage and adverse inflammatory responses. (wikidoc.org)
It also inhibits pulmonary arterial proliferation in response to growth factors, which prevents the closing of arteries by proliferating endothelial cells. (wikidoc.org)
An elevated expression of CCN2 has also been detected by Northern blotting in human invasive mammary ductal carcinomas, dermatofibromas, pyogenic granuloma, endothelial cells of angiolipomas and angioleiomyomas, and in pancreatic tumors. (neuromics.com)
In agreement with CCN2 playing a role in brain tumor angiogenesis, immunocytochemistry studies indicated that both glioblastoma tumor cells and proliferating endothelial cells stained positive for CCN2. (neuromics.com)

It has been shown to be involved in muscle development, bone mineralization, and ureteric bud development. (wikipedia.org)

It has been postulated that the Rho-ROCK pathway can affect the growth of the lung epithelium. (medscape.com)
Such a stem cell divides to produce like stem cells, some of which enter into a pathway of development and differentiation resulting in an end-phenotype which produces highly specialized molecules and/or functions and then, after a time, expires. (case.edu)

An extreme short squama and orbital part of the frontal bone together with the posterior convexity of the coronal bone condensation line suggest that growth inhibition in the sphenofrontal and coronal suture area has its onset very early in fetal life. (medscape.com)
In the cell death assay, the cell populations were similar in each cell type after treatment with FA, indicating that growth inhibition by FA was not related to the induction of apoptosis. (bvsalud.org)
It was also shown that inhibition of the p16 tumour suppressor gene delays growth arrest and therefore senescence of MSC [ 16 ]. (hindawi.com)

This is thought that inducing osteoblastic commitment and differentiation of stem cells such as mesenchymal stem cells. (wikipedia.org)
In vertebrates, the balance between osteoblastic bone formation and osteoclastic bone resorption controls bone homeostasis. (molcells.org)

The ECM provides structural and biochemical support to the cells and has various other functions including cell adhesion, cell to cell communication, and differentiation [ 17 , 18 ]. (hindawi.com)
Module III contains sequences sharing identity with the Thrombospondin type 1 repeat (TSP1) (WSXCSXXCG), which is thought to be implicated in the binding of sulfated glycoconjugates and to be important for cell adhesion. (neuromics.com)
Increased PLF also promoted cell adhesion in MC3T3-E1 osteoblast-like cell cultures. (cdc.gov)

We are excited to announce the U.S. launch of AttraX® Scaffold, an absorbent ceramic-collagen bone graft with an optimized microarchitecture and the new AttraX Scaffold Demo Kit! (nuvasive.com)
The disposable kit features a 2cc sample of AttraX Scaffold with a syringe of artificial bone marrow aspirate to demonstrate its absorbent and moldable handling to your surgeon customers. (nuvasive.com)
Unlike traditional ceramic materials that do not by themselves generate bone formation when implanted in an intramuscular site, AttraX Scaffold has unique microstructure and microporosity that are optimized for bone formation in this environment. (nuvasive.com)
After experiencing AttraX Scaffold firsthand, I am very pleased to offer this scientifically advanced ceramic bone graft to my spinal fusion patients. (nuvasive.com)
This study attempted to assess VEGF and BMP-2 reflecting the effect of hybrid bio-composite scaffold on bone healing in dogs and evaluate the quality of the healing process radiologically. (springeropen.com)

Therefore, providing maintenance of the crestal bone and limiting bone width and height resorption during healing leads to improved socket preservation. (allenpress.com)
Many studies have investigated methods for balance recovery between bone formation and resorption. (molcells.org)

It is involved in the regulation of blood calcium and phosphate levels, bone growth and maintenance, cell differentiation, and gene expression 1 . (dsm.com)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

VEGF has the potential to enhance BMPs-induced bone formation. (springeropen.com)

ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)

Wang Z, Qu YJ, Cui M. Modulation of stem cell fate in intestinal homeostasis, injury and repair. (wjgnet.com)
Currently, there is no consensus whether there is a single or multiple postnatal stem cell population(s) that contribute to skeletal homeostasis and postnatal bone formation. (researchgate.net)
Impairment of the capability of the kidney to produce and reuptake enough calcitriol and therefore maintain vitamin D, phosphate, and calcium homeostasis is one of the principal pathophysiological components of metabolic bone disease in CKD. (karger.com)

Melton, D.A. "Stemness": Transcriptional profiling of embryonic and adult stem cells. (benthamscience.com)
We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)

Thus, the expression of miR-103-3p decreases in MDS BM plasma and MDS-MSCs, significantly impacting MDS-MSCs differentiation. (techscience.com)
Mesenchymal stem cells (MSCs) possess great therapeutic potential. (hindawi.com)
MSCs on PLL-coated plates exhibited a faster growth rate with increased S-phase and upregulated expression of the stemness markers. (hindawi.com)
Additionally, Abedin and King showed that FGF-2 suppresses the cellular senescence of human MSCs [ 17 ]. (hindawi.com)

66(2): 100-106, 2023 Mar. (bvsalud.org)

Cytokines produced by DCs can also promote the differentiation of CD4 + T helper cells as part of immune activation. (rndsystems.com)
We also examined the relationship between inflammatory cytokines, PLF and bone formation processes. (cdc.gov)
We then examined the effect of training or task performance with or without treatment with a rat specific TNFa antibody on inflammatory cytokines, osteocalcin (a bone formation marker), PLF, CTGF, and behavioral indicators of pain or discomfort. (cdc.gov)
fects are so similar that these 2 cytokines are almost interchangeable [ 6 ]. (who.int)

The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
Involvement of bone in lung cancer metastases is a major source of morbidity and mortality arising from skeletal related events (SREs) [ 10 ]. (hindawi.com)
These skeletal malformations are often described as acromelic, meaning that they occur in the bones that are away from the center of the body. (medlineplus.gov)

Above the stem cell zone is the lineage-committed progenitor cells, also known as the transit amplifying zone, divided to fuel the rapid epithelial cell turnover. (wjgnet.com)
Moreover, calcified nodules were detected and osteocalcin expression was confirmed at 3 weeks after induction, suggesting that the differentiation was progressing toward an osteoblast lineage. (jarde.jp)
Differentiate human pluripotent stem cells (hPSCs) to cells of the endoderm lineage with our specialized cell culture media. (stemcell.com)
The experimental approaches use the classical information of both morphogenesis and organogenesis coupled with the new information of the control of developmental lineage progression as controlled by potent growth factors. (case.edu)
The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)
This requirement strongly limits the number of solutions or entiation and lineage-specification, programmed cell death, and ``states'' for the system. (lu.se)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)

These two enzymes ensure that cells acquire maximum protection against oxidative stress. (naturalnews.com)
The variation of the molecular axis Nrf2 (nuclear factor erythroid 2-related factor 2)/PGE2/IL-6 suggests a tight intracellular balance between oxidative stress responses and DPSC differentiation in the presence of Alg/HAp scaffolds. (uni-regensburg.de)

WNT, R-spondin, epidermal growth factor, and mammalian target of rapamycin are secreted by Paneth cells or mesenchymal cells. (wjgnet.com)

However, in human granulosa-like tumor cell line (KGN), treatment with FSH increased BMPR2 expression. (wikidoc.org)
We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. (hindawi.com)
Although there are currently some available palliative treatment options for patients with bone metastases from any solid tumor origin such as radiation therapy and bone targeted/bone strengthening treatments (bisphosphonates and denosumab) that are used in clinical practice, none of them is specific for lung cancer metastases and they do not affect the poor survival outcome of this disease. (hindawi.com)

The CellXVivo ™ Mouse Dendritic Cell Differentiation Kit contains the media and cytokine components to generate immature and mature dendritic cells from mouse bone marrow. (rndsystems.com)

BMP4 secretion helps cause differentiation of the ureteric bud into the ureter. (wikipedia.org)
[ 5 ] Cohen and colleagues have found that in-utero overexpression of the cystic fibrosis transmembrane conductance regulator (CFTR) increased liquid secretion into the lung, accelerating lung growth in a rat model. (medscape.com)

However, Prx1 expressing SSCs (Prx1-SSCs) are not restricted to the bone compartments, but are also located within the muscle and able to contribute to ectopic bone f. (researchgate.net)

The stem cells are commonly subdivided into totipotent, pluripotent, and multipotent according to their plasticity 14 ( table I ). (bvsalud.org)

Stem cells differentiate into different types of cells, such as neural, hematopoietic, adipose, etc. and are used for the treatment of various conditions like myocardial infarction, spinal cord injury, Parkinson's disease and diabetes. (benthamscience.com)
The crypts generate a constant stream of new cells that differentiate and migrate upward into the villi. (wjgnet.com)
It reveals an elegant yet simple system that maintains cells in a stable state, yet enables them to differentiate under the right conditions. (sciencedaily.com)
Instead, it supports the idea that cells differentiate through the collective behavior of multiple genes in a network that ultimately leads to just a few endpoints -- just as a marble on a hilltop can travel a nearly infinite number of downward paths, only to arrive in the same valley. (sciencedaily.com)
But most important, the differences in Sca-1, GATA1 and PU.1 levels across the three cell groups became less pronounced over time, as did the variability in the cells' propensity to differentiate, suggesting that the differences are transient. (sciencedaily.com)
Together, the findings make the case that a slow fluctuation or cycling of gene activity tends to maintain cells in a stable state, while also priming them to differentiate when conditions are right. (sciencedaily.com)
To directly differentiate to pancreatic cells, use our pancreatic progenitor kit to generate functional PDX1 + /NKX6.1 + cells that can be matured into insulin-producing beta cells. (stemcell.com)

Kidney Blood Press Res (2021) 46 (2): 152-161. (karger.com)
5(2)2021 03 05. (bvsalud.org)

Zhang, Y. Integrin β1 increases stem cell survival and cardiac function after myocardial infarction. (benthamscience.com)
Bone metastases can cause a wide range of symptoms that could impair quality of life of lung cancer patients and shorten their survival. (hindawi.com)
For instance, the five-year survival rate for patients with (stage IA) after surgical resection is close to 70% but the five-year survival rate for patients with stage IV (metastatic disease) is as low as 2% [ 4 ]. (hindawi.com)
SCLC is characterized by many features that connote more aggressive nature than NSCLC with fast growth rates and early hematogenous spread with associated 5-year survival rate of 5-10% [ 5 ]. (hindawi.com)
Bone metastasis is a major determinant of treatment outcome, quality of life, and survival for lung cancer patients [ 12 - 14 ]. (hindawi.com)
Certainly, the presence of bone metastasis usually leads to worse outcome and shorter median survival [ 11 , 15 , 16 ]. (hindawi.com)
SCID is considered a pediatric emergency because survival depends on expeditious stem cell reconstitution, usually by bone marrow transplantation (BMT). (medscape.com)

The regenerative medicine is the combination of cells, material engineering, and biochemical factors to improve or replace the biological functions attempting to promote the medicine advancement. (bvsalud.org)

Here, we investigated the effect of GDF-5 on the proliferation of dental pulp cells and their differentiation into odontoblasts by assaying the expression levels of odontoblast marker genes. (ispub.com)
Thyroid transcription factor 1 (TTF-1) is thought to be the earliest embryologic marker associated with cells committed to pulmonary development. (medscape.com)

Angiogenesis is more associated with cancer growth and spreading. (naturalnews.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)

The expressional changes of Hes1, a transcription factor negatively regulating OPC-differentiation, were studied. (biomedcentral.com)

It is produced by Idiopathic nephrotic syndrome (INS) a variety of cells, including monocytes and accounts for 90% of nephrosis in child- mesangial cells in the kidney [ 9 ]. (who.int)

Various grafting materials have been used in oral and periodontal surgeries to augment and rebuild bone intraorally. (allenpress.com)
Bone loss caused by congenital defects, traumatic injury, cancer, reconstructive surgery, or periodontal disease has aroused widespread concern all over the world. (dovepress.com)
2002). It has also been reported that the GDF-5 gene is expressed in dental sac, periodontal ligament, dental pulp cells, and odontoblasts during tooth development (Morotome et al. (ispub.com)

At day 28, bony ankylosis showed increased biological process related to new bone formation, while fibrous ankylosis was characterized by a prolonged immune and inflammatory reaction. (medscimonit.com)
Dendritic cells (DCs) are key mediators of both innate and adaptive immune responses. (rndsystems.com)
2) T cell deficiencies affect the function in killing infected cells or helping other immune cells. (lu.se)

Anatomy62

Organisms12

Diseases10

Chemicals and Drugs90

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology1

Phenomena and Processes49

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Proliferation and differentiation8

Osteogenic16

Vitro10

Osteoblasts13

Regeneration20

Protein40

Tissue28

Proteins16

Chondrogenic differentiation1

Osteoblast differentiation3

Extracellular5

Osteogenesis5

Induces8

Stimulates2

Stromal cells3

Alkaline phosphatase2

Induce5

Pathways6

Mesenchymal stem3

Promotes3

Stimulate4

Vascular6

Recombinant4

Osteoinductive4

Endochondral bone formation1

Progenitor cell2

Cartilage7

Tissues4

Lineages5

Vivo3

Endothelial cells5

Mineralization1

Pathway2

Inhibition3

Osteoblastic2

Adhesion3

Scaffold5

Resorption2

Gene expression2

BMPs1

Abstract1

Homeostasis3

Embryonic2

MSCs4

20231

Cytokines4

Skeletal3

Lineage7

Oxidative stress2

Epidermal growth1

Tumor3

Cytokine1

Secretion2

Ectopic1

Pluripotent1

Differentiate7

20212

Survival7

Promote1

Marker2

Angiogenesis2

Negatively1

Monocytes1

Periodontal3

Immune3