Cell differentiation adult stem cells are multipotent. Medical search. Frequent questions

Previously published data have demonstrated that TBT exposure promotes differentiation of mesenchymal stem cells (MSCs) into adipogenesis, and also increases their lipid content, representing both numerical and qualitative effects on adipocytes. (nih.gov)
MSCs can differentiate into a number of lineages, including muscle, bone, cartilage and fibrocystic cells. (nih.gov)
Objectives: Human mesenchymal stem cells (MSCs) exposed to DDT were used to evaluate the impact on stem cell biology. (nih.gov)
Methods: We assessed DDT-treated MSCs for self-renewal, proliferation, and differentiation potential. (nih.gov)
Expression of factors in DDT-treated cells was similar to that in estrogen-treated MSCs, suggesting that DDT may function via the estrogen receptor (ER)-mediated pathway. (nih.gov)
Mesenchymal stem cells (MSCs) are highly abundant in the amniotic fluid and several techniques have been described for their isolation. (wikipedia.org)
Human leukocyte antigen testing has been utilised to confirm that the MSCs stem from the fetus and not from the mother. (wikipedia.org)
Originally it was proposed that the MSCs were discarded from the embryo at the end of their life cycle but since the cells remained viable in the amniotic fluid and were able to proliferate in culture this hypothesis was overturned. (wikipedia.org)
However, the cultured amniotic fluid-derived MSCs have a similar phenotype to both adult bone-marrow-derived MSCs and MSCs originating from second trimester fetal tissue. (wikipedia.org)
In this study we demonstrate that adult bone marrow- derived mesenchymal stem cells (MSCs) undergo neoplastic transformation induced by the human polyomavirus JCV, early protein, T-antigen, and are tumorigenic when transplanted into the flanks of Nude mice as compared to non-transformed MSCs. (nih.gov)
They are characterized as totipotent (can generate all types of cells including germ cells (ESCs), pluripotent (can generate all types of cells except cells of the embryonic membrane), multipotent (can differentiate into more than one mature cell (MSC)), self-renewable (can divide without differentiation and create everlasting supply), and malleable stem cells (MSCs have plasticity and can undergo differentiation. (axonmedchem.com)
The caveolin-1 null mouse also has increased bone mass and an increased bone formation rate, and its bone marrow-derived mesenchymal stem cells (MSCs) have enhanced osteogenic potential. (nih.gov)
Expression of caveolin-1 increases in MSCs induced to undergo osteogenic differentiation, and siRNA-mediated knockdown of caveolin-1 expression enhances MSC proliferation and osteogenic differentiation. (nih.gov)
Taken together, these findings suggest that caveolin-1 normally acts to regulate the differentiation and renewal of MSCs, and increased caveolin-1 expression during MSC osteogenesis likely acts as a negative feedback to stabilize the cell phenotype. (nih.gov)
Intramyocardial transplantation of mesenchymal stem cells (MSCs) has emerged as a leading contender in the pursuit of clinical intervention and therapy. (springer.com)
MSCs are capable of secreting a large array of soluble factors, which have had demonstrated effects on pathogenic cardiac remolding, fibrosis, immune activation, and cardiac stem cell proliferation within the damaged heart. (springer.com)
MSCs are also capable of differentiation into cardiomyocytes, endothelial cells, and vascular smooth muscle cells, although the relative contribution of trilineage differentiation and paracrine effectors on cardiac repair remains the subject of active investigation. (springer.com)
While there is some overlap, the most common categories of adult stem cells are mesenchymal stem cells (MSCs) and hematopoietic stem cells which are both defined based upon specific stem cell surface markers [ 3 ]. (hindawi.com)
In view of ethical concerns and current regulatory issues associated with embryonic or perinatal stem cells, orthopaedic stem cell research has predominantly focused upon MSCs. (hindawi.com)
MSCs (also referred to as mesenchymal stromal cells) are defined by their ability to self-renew and their multipotentiality [ 6 ]. (hindawi.com)
MSCs are defined by three characteristics: (i) an ability to adhere to plastic, (ii) presentation of stem cell specific antigens, and (iii) the potential to form multipotent mesenchymal cells which can differentiate into a number of cell lines interesting to musculoskeletal medicine such as osteocytes, chondrocytes, and adipocytes [ 7 - 9 ]. (hindawi.com)
Induction of MSCs into specific cell lineages such as tenocytes is determined by culturing processes as well as growth and media conditions (Figure 1 ). (hindawi.com)
Bone marrow is the traditional source of human multipotent mesenchymal stem cells (MSCs), but placenta appears to be an alternative and more readily available source. (stemcellthailand.org)
Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)
Mesenchymal adult stem cells ( MSCs ) are stromal cells with anti-inflammatory , immunomodulatory , self-renewal , cell-division , signaling , and multilineage differentiation properties. (plexusnc.com)
The multipotent nature of MSCs make them the ideal choice for treating a variety of neurological disorders. (plexusnc.com)
The differentiation of MSCs may be affected by growth factors, hormones, source of the MSCs, presence of other cells in the microenvironment (laboratory conditions), etc. (plexusnc.com)
MSCs have the potential to differentiate into different types of specialized cells. (plexusnc.com)
MSCs promote tissue regeneration by secreting cytokines and growth factors that can bring new cells/tissues to the site of injury or damage. (plexusnc.com)
It has been shown that mesenchymal stem cells (MSCs) obtained from umbilical cords, dental pulp and adipose tissue, which are all biological discards, are able to differentiate into muscle, fat, bone and cartilage cell lineages. (biomedcentral.com)
The aim of this study was to isolate, expand, characterize and assess the differentiation potential of MSCs from human fallopian tubes (hFTs). (biomedcentral.com)
Mesenchymal stem cells (MSCs) are promising candidates for cellular therapies ranging from tissue repair in regenerative medicine to immunomodulation in graft versus host disease after allogeneic transplantation or in autoimmune diseases. (biomedcentral.com)
Mesenchymal stem or stromal cells (MSCs) are multipotent adult stem cells capable of differentiating into cells of mesodermal origin such as bone, cartilage, muscle, connective tissue, and fat. (biomedcentral.com)
Due to their diverse differentiation potentials, the relative ease of their isolation from multiple tissues, the fact that they can be expanded and multiplied in vitro , and their immunomodulatory properties, MSCs are regarded as a promising tool for clinical applications. (biomedcentral.com)
MSCs are notoriously heterogeneous, comprising cell subpopulations that might have unexpected effects or adverse side effects on the recipient [ 10 ]. (biomedcentral.com)
Therefore, there is an urgent need to establish robust high-throughput approaches to define primary human MSCs from different donors and tissues as well as distinguish them from closely related cell types, such as fibroblasts. (biomedcentral.com)
Functional fingerprinting based on cell viability might complement current MSC characterization methods, such as surface marker expression and differentiation assays, to increase the repertoire for a better definition of MSCs. (biomedcentral.com)
Bone marrow: Bone marrow is a rich source of two important adult stem cell lineages: Hematopoietic Stem Cells (HSCs) and Mesenchymal Stem Cells (MSCs). (ijbiotech.com)
Mesenchymal Stem Cells (MSCs): There are different sources of MSCs and their isolation is relatively easy. (ijbiotech.com)
So far several cell types have been differentiated from MSCs. (ijbiotech.com)
Mesenchymal stem cells (MSCs) are multipotent stem cells that have the ability to self renew and exhibit multilineage differentiation. (alphacelle.com)
In the context of diabetes, MSCs are able to regenerate pancreatic islet beta cells, protect endogenous pancreatic islet beta cells from apoptosis, and ameliorate insulin resistance of peripheral tissues. (alphacelle.com)
Mesenchymal stem cells (MSCs) have unique biological properties due to their stem cell nature. (biomedcentral.com)
The significant capability of MSCs to proliferate in vitro and differentiate into different cells introduces these cells as therapeutic agents for regenerating necrotic cells or for connective tissue apoptosis. (biomedcentral.com)
Other investigations have indicated that most injected MSCs are commonly trapped in the liver, spleen, and lungs and that a small number of these cells reach the damaged site. (biomedcentral.com)
Neural stem cells (NSCs), embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), and induced pluripotent stem cells (iPSCs) are all promising candidates for the treatment of SNHL. (genesispub.org)
Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
In this mini review, we will discuss point by point possible pitfalls in the production of human MSCs for cell therapies, without consideration of material-based applications. (frontiersin.org)
Only a careful consideration and standardization of all pretreatment processes/methods for the different applications of MSCs will ensure robust and reproducible performance of these cell populations in the different experimental and clinical settings. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
MSCs are often utilized for cell transplantation directly into tissues, or seeded in biomaterial scaffolds to repair tissues, such as bone or cartilage defects. (nih.gov)
This session will discuss the current state of the science in stem cell research, including the biology of ESCs, iPSCs, and ASCs (with the emphasis on MSCs), their potential applications, as well as advantages and disadvantages, and opportunities for future NIAMS-funded research. (nih.gov)

The hope is that, when exposed to the optimal microenvironment, stem cells will differentiate in a manner appropriate to the local brain region, and integrate seamlessly with the existing circuits of the host. (nih.gov)
In the diseased retina, precursor cells differentiate into new neurons that appear to incorporate into local circuitry. (nih.gov)
Together, these results demonstrate the ability of stem cells to differentiate and integrate appropriately into the damaged or diseased CNS. (nih.gov)
In 2007, it was confirmed that the amniotic fluid contains a heterogeneous mixture of multipotent cells after it was demonstrated that they were able to differentiate into cells from all three germ layers but they could not form teratomas following implantation into immunodeficient mice. (wikipedia.org)
Although those cells which expressed the markers were able to differentiate into muscle, adipogenic, osteogenic, nephrogenic, neural and endothelial cells, this did not necessarily occur from a homogenous population of undifferentiated cells. (wikipedia.org)
Stem cells, by definition, are cells able to self-renew, with a single cell able to differentiate into multiple, functional cell types. (medscape.com)
[ 2 , 3 ] HSCs, for instance, have been reported to differentiate into muscle fibers able to reconstitute dystrophin expression in models of muscular dystrophy, and into other cell types of mesodermic origin, such as bone and endothelium. (medscape.com)
Approximately 500-600 studies are now reporting observations of this kind, with HSCs induced to differentiate into a variety of nonblood cells. (medscape.com)
The resulting iPSCs resemble embryonic stem cells (ESCs) in their properties and potential to differentiate into a variety of adult cell types. (nature.com)
Taken together, this thesis reveals improved ways to propagate and differentiate hESCs in culture, and has uncovered common differentiation factors present in both human neuroblasts and NPs. (5dok.org)
Multipotent cells isolated from human term placenta (placenta-derived multipotent cells [PDMCs]) have been known to be able to differentiate into mesodermal lineage cells, including adipocytes and osteoclasts. (stemcellthailand.org)
Stem cells (SCs) are undifferentiated cells with self-renewal ability and capacity to differentiate into specialized cell types. (bvsalud.org)
Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
The ability to self-renew and differentiate into different types of specialized cells has made stem cells become a preferred choice for treating neurological disorders like Parkinson's, Spinocerebellar Ataxia, motor neuron diseases like ALS, and others. (plexusnc.com)
Stem cells are immature cells that can differentiate into specific cells such as blood cells to replace damaged ones and ensure proper body function. (uclmed.tech)
This occurs naturally in humans, for example, olfactory stem cells in the olfactory epithelium are induced to differentiate into olfactory sensory neurones, which are responsible for the processing of smell. (uclmed.tech)
On the other hand, pluripotent stem cells are present in the blastocyst's inner cell mass and can differentiate into any type of cell in the human body (apart from placental cells). (uclmed.tech)
Stem cells are undifferentiated biological cells that can differentiate into distinct specialized cells and divide to produce more stem cells through the process of mitosis. (electronichealthreporter.com)
Adult stem cells - They are multipotent stem cells, this means that they can differentiate into a range of other cell types. (electronichealthreporter.com)
At this stage, any of the cells can differentiate to form any tissue in the body. (electronichealthreporter.com)
The functions of stem cells are numerous judging from their ability to repair other cells and differentiate into new cells. (electronichealthreporter.com)
In developing embryos, stem cells have the ability to differentiate into all the specialized cells. (electronichealthreporter.com)
Stem cells are cells that are capable of dividing repeatedly and have the ability to differentiate into any other type of cell in the human body (e.g. muscle, skeletal, neural, etc. (orthopedia.gr)
ESCs are pluripotent, meaning they can differentiate into any cell type in the body. (falconediting.com)
Neural stem cells (NSCs) are able to differentiate into neurons and astroglia. (biomedcentral.com)
Appropriate induction medium was used to differentiate these cells into adipocytes, osteocytes, and chondrocytes. (molvis.org)
Early passaged cells when induced were able to differentiate into adipocytes, osteocytes and chondrocytes. (molvis.org)
Synovial sarcoma is derived from multipotent stem cells, which can differentiate into mesenchyma and epithelial structures. (thieme-connect.com)
For example, neural stem cells derived from ectoderm can differentiate into ectoderm, mesoderm, and endoderm. (ijbiotech.com)
The HSCs with self-renewal capacity can differentiate into different types of blood cells, including those involved in the human immune system. (ijbiotech.com)
These cells can regenerate themselves and differentiate into multiple cells [ 1 ]. (biomedcentral.com)
They have the potential to be induced to differentiate into sensory hair cells and spiral ganglion neurons (SGNs) in damaged cochleae. (genesispub.org)
Stem cells have the marked ability of self-renewal as well as the capacity to differentiate into mature cells of a particular tissue [6]. (genesispub.org)
Cells derived from the inner cell mass (ICM) of the blastocyst are considered to be pluripotent, and these are able to differentiate into nearly all cells arising from the three embryonic germ layers. (genesispub.org)
These cells feature many of the same properties as adult stem cells, particularly in that they have the capacity to differentiate into a specific type of cell. (nih.gov)
Stem cells are characterized by both the ability to renew themselves, as well as to generate progeny that differentiate into more specialized cells. (nih.gov)

In the central nervous system (CNS), cell-replacement strategies are of particular interest because, unlike other tissues, the mature brain and spinal cord have little capacity for self-repair. (nih.gov)
Another promising area of research lies in exploring the extent to which precursor cells derived from non-neural tissues, or from different stages of development, can generate specific classes of neurons and glia that can be used to repair particular neural circuits. (nih.gov)
Stem cell isolation and expansion for peripheral nerve repair (PNR) can be achieved using a wide diversity of prenatal and adult tissues, such as bone marrow or brain tissues. (wjgnet.com)
If these mechanisms can be harnessed to obtain cells specifically required for therapy, diagnosis or drug discovery, it may be possible to restore function to tissues and organ systems that have been compromised by congenital disorders, developmental malfunction, age, injury, disease or drug exposure. (nih.gov)
Although animal studies demonstrate that stem or progenitor cells can be derived from a variety of tissues and from hosts of different ages, the requirements and potential for differentiation of each type of pluripotent cell appear to be unique. (nih.gov)
Particularly, the identification of a rare population of adult stem cells in the most tissues/organs in human has emerged as an attractive source of multipotent stem/progenitor cells for cell replacement-based therapies and tissue engineering in regenerative medicine. (nih.gov)
In addition, the genetically-modified adult stem/progenitor cells could also be used as delivery system for expressing the therapeutic molecules in specific damaged areas of different tissues. (nih.gov)
In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)
Frequently the beneficial effects of MSC persist long after their disappearance from host tissues, suggesting that MSC interact with intermediate cells in the host that relay or amplify their effects. (biomedcentral.com)
Human mesenchymal stem/progenitor cells (MSC) from bone marrow, adipose tissues, placenta, umbilical cord and other tissues are currently being administered to large numbers of patients. (biomedcentral.com)
They are adult stem cells that can divide and develop into many specialized cell types in specific organs and/or tissues, and are considered to be ideal for organ transplantation procedures. (plexusnc.com)
The mesoderm alone gives rise to different types of connective cells/tissues like cartilage, muscle, bone, and fat. (plexusnc.com)
Ethical restrictions on the use of unborn children's tissues are also a factor in preventing treatment using embryonic stem cells. (electronichealthreporter.com)
Their main function is the repairing and replenishing of adult body tissues. (electronichealthreporter.com)
Stem cells, in general, also function to maintain a normal overturning of regenerative tissues such as blood, skin or intestinal tissue. (electronichealthreporter.com)
This is based on the ability of scientists to isolate and culture stem cells from bone marrow, adipose tissues and other sites. (electronichealthreporter.com)
Adult stem cells found in certain tissues of a fully developed human being are restricted to producing only certain types of specialized cells. (orthopedia.gr)
Adult stem cells were discovered 40 years ago when the researchers observed that the cells in the bone marrow were capable of promoting the formation of various tissues. (orthopedia.gr)
The search for sources to obtain multipotent stem cells from discarded tissues or through non-invasive procedures is of great interest. (biomedcentral.com)
These progenitor cells which constitute a reservoir found within the connective tissue of most organs are involved in the maintenance and repair of tissues throughout the postnatal life of an individual. (biomedcentral.com)
Adult stem cells, also known as somatic or tissue-specific stem cells, exist in various tissues throughout the body, such as bone marrow, skin, and fat. (falconediting.com)
Adult Stem Cells "are undifferentiated cells found living within specific differentiated tissues in our bodies that can renew themselves or generate new cells that can replenish dead or damaged tissue. (kinesiologyshop.com)
Most epithelial tissues self-renew throughout adult life due to the presence of multi-potent stem cells and/or unipotent progenitor cells. (kinesiologyshop.com)
Oxidative stress is a phenomenon caused by an imbalance between production and accumulation of oxygen reactive species (ROS) in cells and tissues and the ability of a biological system to detoxify these reactive products. (kinesiologyshop.com)
Few subjects in biomedical science have captured the imagination of both the scientific community and the public as has the use of stem cells for the repair of damaged tissues. (jci.org)
At HSC/MPP level, this is functionally imparted by a subset of phenotypic CD71 + HSC/MPPs, exclusively producing erythrocytes and megakaryocytes, highly abundant in PB but rare in other adult tissues. (kumamoto-u.ac.jp)
This drastically increases the supply of cells and tissues available for transplant into patients. (ed.ac.uk)
We conclude that CR positively affects the pool of VSELs in adult tissues and explains the positive effect of CR on longevity. (biomedcentral.com)
Senescence in adult tissues can be classified in two main subcategories, based on the underlying molecular mechanism: replicative (or intrinsic), caused by telomere shortening, and stress-induced, in response to reactive oxygen species (ROS) and/or oncogenes [ 7 - 9 ]. (hindawi.com)
Release of proinflammatory cytokines from activated host tissues increases HLA expression on host cells and enhances their antigen-presenting ability. (basicmedicalkey.com)
Finally, activated immune cells mediate the destruction of host tissues and result in multiple organ GVHD. (basicmedicalkey.com)
These reservoir cells play a major role in development and growth of the tissues and organs. (ijbiotech.com)
Bone marrow, embryo and cord blood are the major stem cell sources which are believed to act systemically for regeneration of tissues and organs in an organism. (ijbiotech.com)
In addition to embryonic and adult stem cells, there are other sources such as skin, which is a good source of adult stem cells involved in local repair and regeneration of epidermal and dermal tissues (1). (ijbiotech.com)
The diversity of the stem cells present in different tissues implies that the body reserves all the cell types with stemness properties to guarantee important physiological processes and regeneration of organs. (ijbiotech.com)
Adult stem cells: The pluripotency of adult stem cells isolated from different tissues was approved by showing their differentiation potential into cell types from different germ layers. (ijbiotech.com)
An organoid is a miniature, self-organized, three-dimensional (3D) structure composed of tissues derived from various sources including tissues and stem cells. (j-organoid.org)
In a clinical trial on patients with cirrhosis, it was shown that mesenchymal stem cells were trapped in the lungs in the early hours after injection into peripheral blood and that they left the lungs after 48 h, migrated to the liver and spleen, and remained in these tissues for several days [ 18 ]. (biomedcentral.com)
Progenitor cells have the potential to develop into several different types of tissues and have been considered as a candidate cell type to treat injuries by means of tissue engineering and regenerative medicine. (nih.gov)
In adult tissues, somatic stem cells are essential for normal homeostasis and tissue repair. (nih.gov)
The NIAMS has made a significant investment in stem cell research, as it pertains to NIAMS relevant tissues. (nih.gov)
The unique value of nuclear transplantation technology is that the embryonic stem cells and the differentiated cells and tissues they yield have the same genetic makeup as the individual that donated the nucleus. (nih.gov)
Consequently, they can be used to repair or replace damaged or diseased tissues without invoking the immune rejection that would occur with unmatched cells. (nih.gov)
Both Congressman Weldon and Senator Brownback have accepted the assurances of their advisors that adult-derived tissue- specific stem cells, that is specialized stem cells that already exist in many of our tissues, are sufficient for meeting the clinical needs of repairing damaged or diseased tissue. (nih.gov)

the former leads to stem cell exhaustion, and the latter leads to breaches of mesodermal tissue integrity. (nature.com)
Might it be that adult stem cells (ASCs) hold the same clinical potential of embryonal stem cells (ESCs), thus allowing researchers to bypass most of the ethical and practical issues related to the preparation and use of ESCs for cell and tissue replacement? (medscape.com)
Stem cells also fulfill a second requirement: They can functionally reconstitute a given tissue in vivo. (medscape.com)
[ 2 ] Tissue-specific stem cells of hematopoietic, keratinocytic, or neural origin fulfill this definition, although it is not quite well understood how neural stem cells do it, and some uncertainty still surrounds the potency of keratinocytic stem cells. (medscape.com)
Analysis of the cells used in these studies has become more sophisticated over time, with a wider application of Y chromosome detection by fluorescence in situ hybridization (FISH), the determination of tissue-specific expression of the beta-galactosidase or green fluorescent protein markers, and finally adoption of the Cre/lox system that allow more accurate cell tracking. (medscape.com)
In order to be useful for stem cell research, these cells cannot have differentiated into specific types of tissue, such as bone, cardiac, skin, or nerve. (wheelchairkamikaze.com)
The component technologies being brought together include induced pluripotent stem cells (iPSCs), 3D cell culture (which is beginning to involve vascularization), tissue-chip bioreactors that enable the recreation to tissue-like microenvironments, and the hardware required to operate coupled microphysiological systems in a manner that recapitulates human physiology and its response to drugs and toxins. (selectbiosciences.com)
Cell-biology-related research on preadipocyte (adiposal-mesenchymal cell) differentiation laid the foundation for discoveries of adipose-derived cells (both in stromal vascular fraction, or SVF, and adipose-derived stromal/stem cells, or ASCs), which had become an increasing interest to both stem cell biologists and clinicians because of their potential for angiogenesis and suppression of inflammation for tissue engineering and treatments. (scirp.org)
Ensuing specialists later determined that this multifunctional organ contained a number of valuable resident cells, other worthy non-indigenous cellular populations and a quantity of distinct structural elements, which possessed the potential to optimize fat graft survival and eventually further tissue engineering applications in regenerative medicine. (scirp.org)
Recent progress on tissue-resident adult stem cell biology and their therapeutic implications. (nih.gov)
The tissue-resident adult stem/progenitor cells offer the possibility to stimulate their in vivo differentiation or to use their ex vivo expanded progenies for cell replacement-based therapies with multiple applications in human. (nih.gov)
Stem cells are defined as a population of cells that can self-renew through symmetrical mitotic division, form daughter cell lines, and generate a broad range of tissue lineages through terminal differentiation [ 1 , 2 ]. (hindawi.com)
These categories include embryonic, peri-natal (obtained from the umbilical cord or from amniotic tissue), somatic adult, or induced pluripotent stem cells (iPSCs). (hindawi.com)
The low infection rate and young age of placenta compared with other tissue origins of adult stem cells make theses cells attractive target for cell-based therapy. (stemcellthailand.org)
The use of ASCs in regenerative medicine and tissue engineering research has important advantages in comparison with ESCs, since there are no ethical complications and the process of differentiation of these cells is better controlled. (bvsalud.org)
In explant method, the dental tissue is placed on a plastic surface and the cells migrate out from the tissue fragment adhering to culture flasks or dishes ( Figure 1 ). (bvsalud.org)
Tissue engineering and regenerative medicine research seeks better treatment alternatives through the application of adult renal stem cells. (biomedcentral.com)
Multipotent stem cells have a more limited regeneration capacity, and their differentiation range is dependent on their tissue of origin. (uclmed.tech)
These adult stem cells can be found in a few locations in the body such as bone marrow, adipose tissue or gonads. (electronichealthreporter.com)
Upon severe injury, these adult tissue stem cells are activated and go on to reconstitute all of the cellular constituents of this sensory epithelium. (nih.gov)
Our studies provide a model for understanding the mechanisms regulating neural stem cells and lay the groundwork for the future development of treatments and therapeutics to ameliorate tissue damage and degeneration in the nervous system. (nih.gov)
Adult stem cells under appropriate conditions are capable of growing into other types of cells with the ability to aid tissue regeneration. (orthopedia.gr)
Currently, stem cells are used in degenerative diseases of the shoulder, knee, hip and spine as well as in soft tissue injuries (muscles, tendons and ligaments) and bone related injuries. (orthopedia.gr)
In the body, each organ and tissue is made of cells that are highly specialized to a particular function. (brighthub.com)
Stem cells that are derived from a developed tissue, such as the umbilical cord, bone marrow, or skin, are called adult stem cells. (brighthub.com)
Unlike ESCs, these cells are multipotent, which means they have a more limited differentiation potential, typically restricted to the tissue from which they originate. (falconediting.com)
The adult bone marrow has been generally considered to be composed of hematopoietic tissue and the associated supporting stroma. (kinesiologyshop.com)
The skin's elixir for maintaining tissue homeostasis, regenerating hair, and repairing the epidermis after injury is its stem cells, which reside in the adult hair follicle, sebaceous gland, and epidermis. (kinesiologyshop.com)
Therefore, transplantation of embryonic stem cell (ESC)-derived NSCs has been promulgated as a new potential therapeutic approach for several neurodegenerative disorders and psychiatric disorders including Alzheimer's disease, Parkinson's disease, spinal cord injuries and Huntington's disease [ 4 ], highlighting a potential prospection in developing strategy for neural replacement and regeneration in tissue engineering. (biomedcentral.com)
Tissue stem cells - These cells are found in your body and provide new cells to your organs. (ed.ac.uk)
They can usually only make a limited number of different cell types which are specific to the organ or tissue that they are found in. (ed.ac.uk)
However, VSELS have the potential to become specified into more-differentiated tissue-committed stem cells (TCSCs) after reversing expression of imprinted genes to the somatic type [ 5 ]. (biomedcentral.com)
Pathologies, as atherosclerosis, cardiac fibrosis, and cardiomyopathy, are often linked to the failure of cardiovascular tissue cells to reenter the cell cycle, namely, senescence, due to endogenous or exogenous causes. (hindawi.com)
Tissue damage caused by donor T cells creates a cytotoxic environment and leads to recruitment of additional effector cells including NK cells and neutrophils, which leads to additional damage and immune cell recruitment, creating a cycle that is difficult to break. (basicmedicalkey.com)
Cytotoxic T cells and NK cells respond and stimulate monocytes to produce IL-1 and TNF-α, directly resulting in tissue damage. (basicmedicalkey.com)
T cells express the ligand for Fas on their surface and when they enter the liver they bind the Fas receptors (3), initiating the apoptosis pathway that leads to tissue scarring (4). (the-scientist.com)
These cells have been isolated from human and mouse tissue as well as from cell lines originated from the mammary gland that can give rise to both the luminal and myoepithelial cell types of the gland. (ijbiotech.com)
Neural stem cells: The presence of stem cells in the mature animal brain tissue indicates that during the neurogenesis process generation of new neurons continues into adulthood. (ijbiotech.com)
Since organoid technology has become an independent field of research, a precise understanding of organogenesis in a dish will be a significant factor for the research and use of tissue or stem cell-derived organoids [ 3 ]. (j-organoid.org)
This finding became the spark for further developments in organoid research, leading to successful application in cultures of other tissue types such as stomach, pancreas, liver, colon, brain, lung, and heart from human tissue or pluripotent stem cells (PSCs) [ 6 ]. (j-organoid.org)
In the meantime, exosomes derived from mesenchymal stem cells have attracted the attention of many researchers and physicians due to their unique ability to modulate the immune system, repair tissue and reduce inflammation. (biomedcentral.com)
MSC migrate to the inflammation site through adhesion molecules and integrins such as VCAM-1 and VLA-4, affecting the damaged tissue through cell-cell contact and secretion of various trophic factors [ 17 ]. (biomedcentral.com)
Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
NIAMS scientists have discovered that tissue removed from traumatic wounds, traditionally considered medical waste, can be a source of progenitor cells. (nih.gov)
Researchers are currently studying ways to use progenitor cells to improve healing at the site of an injury, and traumatized tissue may provide an alternative source of cells for these therapies. (nih.gov)
The researchers collected the debrided tissue and isolated mesenchymal progenitor cells, a type of cell that has the potential to develop into bone, fat, or cartilage cells. (nih.gov)
The researchers plan to continue their research to find better and faster isolation techniques, with the hope that the cells could be used quickly and effectively in the clinical setting to treat patients soon after injury for the purpose of tissue regeneration. (nih.gov)
Differentiation Potential of Multipotent Progenitor Cells Derived from War-Traumatized Muscle Tissue. (nih.gov)
A session at the 2006 NIAMS Scientific Retreat focused on the biology of stem cells in muscle and skin, with an emphasis on identification and characterization of the stem cell populations, regulation of stem cell maintenance within the stem cell niche, control of differentiation of stem cell progeny to more mature cell types, and the roles that the stem cells play in tissue homeostasis and the repair of tissue injury. (nih.gov)
There is currently considerable enthusiasm for the potential use of stem cells for tissue engineering and regenerative medicine. (nih.gov)
In theory, pluripotent embryonic stem cells (ESCs) might have scientific advantages for tissue engineering and regenerative medicine applications. (nih.gov)

Primary sensory neurons in the olfactory epithelium are continuously regenerated throughout adult life via the proliferation and differentiation of multipotent neural progenitor cells. (nih.gov)
For example, we use conditional genetic knockouts to investigate the roles of certain transcription factors and intracellular signaling pathways in promoting stem-cell self-renewal, proliferation, and differentiation. (nih.gov)
miRNAs have been demonstrated to be involved in NSC self-renewal, proliferation and differentiation. (biomedcentral.com)
Furthermore, enforced expression of DLL4 partially reversed the effects of miR-124 on NSCs proliferation and differentiation. (biomedcentral.com)
miR-124 promoted proliferation and differentiation of NSCs through inactivating Notch pathway. (biomedcentral.com)
However, the molecular mechanisms of miR-124 associated with proliferation and differentiation of NSCs are still unknown. (biomedcentral.com)
Transplanted donor T cells are activated upon interaction with host antigen resulting in proliferation and differentiation. (basicmedicalkey.com)

TBT has major adipogenic effects when exposed in utero or in adult multipotent stem cells. (nih.gov)
DDT enhanced both adipogenic and osteogenic differentiation, which was confirmed by increased mRNA expression of glucose transporter type 4 ( GLUT4 ), lipoprotein lipase ( LpL ), peroxisome proliferator-activated receptor gamma ( PPAR γ), leptin, osteonectin, core binding factor 1 ( CBFA1 ), and FBJ murine osteosarcoma viral oncogene homolog ( c-Fos ). (nih.gov)
Recent advances in adipogenesis had provided insights into understanding of the complex cues for influencing the cytoarchitecture, epigenomic remodeling, signaling pathways and transcription regulators on gene actions for both white and brown adipogenic progression from mesenchymal stem cells to matured committed adipocytes. (scirp.org)
2012 . Bisphenol A diglycidyl ether induces adipogenic differentiation of multipotent stromal stem cells through a peroxisome proliferator-activated receptor gamma-independent mechanism. (nih.gov)
Lineages of hFTs were expanded, had their karyotype analyzed, were characterized by flow cytometry and underwent in vitro adipogenic, chondrogenic, osteogenic, and myogenic differentiation. (biomedcentral.com)

Physiological aging is associated with a progressive loss of function and a decline in the self-renewal and regenerative capacities of CNS stem cells. (frontiersin.org)
Conclusion: stem cells from dental origin are an interesting alternative for research and application in regenerative therapies in Dentistry. (bvsalud.org)
8,9 Because dental stem cells (DSCs) are easy to obtain and present a great potential of differentiation, there has been a growing interest in their use in regenerative medicine for treatment of various human diseases. (bvsalud.org)
Researchers are working on ways to enhance these cells' regenerative properties in response to injury and ageing, in which cases the number of available stem cells decreases, implying that the natural process of regeneration is insufficient. (uclmed.tech)
The regenerative capacity of the olfactory epithelium therefore presents a powerful and experimentally accessible paradigm for elucidating the mechanisms regulating neural stem-cell function. (nih.gov)
The possibility of using stem cells for regenerative medicine has opened a new field of investigation. (biomedcentral.com)
In the realm of regenerative medicine, stem cells offer hope for individuals suffering from debilitating conditions. (falconediting.com)
As scientists continue to unravel the complexities of stem cells and navigate ethical considerations, the future of regenerative medicine shines brightly, offering new possibilities for improving human health and well-being. (falconediting.com)
Human embryonic stem cells offer the promise of a new regenerative medicine in which damaged adult cells can be replaced with new cells. (jci.org)
5. Human embryonic stem cells: culture, differentiation, and genetic modification for regenerative medicine applications. (nih.gov)
For lots more information and resources about stem cells and regenerative medicine, including information about using stem cells in the clinic and clinical trials of stem cell therapies, visit the EuroStemCell website. (ed.ac.uk)
It has revolutionised the fields of stem cell research and regenerative medicine. (ed.ac.uk)
This review will focus on the cardiovascular pathologies correlated to senescence, the effect of aging on the cardiac endogenous resources of stem cells, and the potential strategies of regenerative medicine to be applied to maintain the heart younger and healthier. (hindawi.com)
This review article discusses the biogenesis and sources of exosomes, MSC-derived exosomes, the use of these exosomes in regenerative medicine, and treatments based on exosomes derived from stem cells in respiratory diseases. (biomedcentral.com)
The reason for the lack of regenerative capacity in the cochlea could be that the differentiated cell types that contribute to the structure of the organ of Corti lose their regenerative and proliferative ability during post-natal maturation [5]. (genesispub.org)

In rodent models of Parkinson's Disease, precursor cells induce functional recovery, if differentiated into dopaminergic neurons before transplantation into the striatum. (nih.gov)
Do the cell-manipulation and transplantation techniques affect the results obtained in different sets of experiments? (medscape.com)
Menasche P (2003) Myoblast-based cell transplantation. (springer.com)
In this book, world-renowned experts in the field of hematopoietic cell transplantation examine a range of issues and controversies relating to apheresis, with the aim of identifying current trends and best practices. (nshealth.ca)
This book, featuring numerous helpful tables, algorithms, and figures, will be of high practical value for residents, fellows, faculty members and other healthcare personnel involved in hematopoietic cell transplantation. (nshealth.ca)
13. Extracorporeal Photopheresis in Hematopoietic Cell Transplantation -- 14. (nshealth.ca)
Nevertheless, great advancements have been made in this field, such as the use of haematopoietic stem cell transplantation to treat blood disorders and the development in the understanding of using neural stem cells to treat neurodegenerative diseases. (uclmed.tech)
An example is haematopoietic stem cell transplantation, also known as bone marrow transplantation. (uclmed.tech)
10. Differentiation of encapsulated embryonic stem cells after transplantation. (nih.gov)
After transplantation, donor T cells enter the inflammatory environment and recognize alloantigens presented by APCs. (basicmedicalkey.com)
The transplantation of oligodendrocytes derived from human ES cells into spinal cord-injured individuals was the world's first human ES cell human trial approved by FDA. (ijbiotech.com)
Previous clinical trials of muscle progenitor cell transplantation for the treatment of muscular dystrophy were not successful, due to the poor survival of the transplanted cells. (nih.gov)

Even more difficult to understand has been the observation of differentiation into neurons and astrocytes of HSCs grafted from bone marrow. (medscape.com)
Applications of apheresis devices in the processing of bone marrow grafts are discussed, and detailed attention is devoted to the indications and rationale for therapeutic apheresis procedures, with individual chapters focusing on therapeutic plasma exchange and immunoadsorption, red cell exchange, and extracorporeal photopheresis. (nshealth.ca)
This study comprehensively compared human placenta-derived MSC (hpMSC) and human bone marrow-derived MSC (hbmMSC) in terms of cell characteristics, optimal growth conditions and in vivo safety specifically to determine if hpMSC could represent a source of human MSC for clinical trial. (stemcellthailand.org)
These cells have been studied for the treatment of periodontitis, bone repair, regeneration of the pulp after necrosis as well as the development of new teeth. (bvsalud.org)
These stem cells are obtained from a compatible donor or the patient's bone marrow and then infused into the patient's bloodstream. (uclmed.tech)
Once engrafted, these stem cells repopulate the bone marrow, replacing the damaged or cancerous cells with healthy ones (Khaddour, Hana and Mewawalla, 2023). (uclmed.tech)
This procedure uses autologous adult stem cells from the patient's own bone marrow. (orthopedia.gr)
They are capable of developing into any of several types of cell, such as blood cells, bone cells, nerve cells, skin cells, etc. (brighthub.com)
There are many kinds of blood cell, and a multipotent blood stem cell (hematopoietic cell) can become any kind of blood cell, but not another kind of cell such as a bone cell. (brighthub.com)
Rare hematopoietic stem and progenitor cell (HSPC) pools outside the bone marrow (BM) contribute to blood production in stress and disease but remain ill-defined. (kumamoto-u.ac.jp)
These animals have very low levels of circulating insulin-like growth factor 1 (IGF-1) in peripheral blood (PB), maintain higher numbers of hematopoietic stem cells (HSPCs) in bone marrow (BM), and display prolonged fecundity compared with wild type littermates. (biomedcentral.com)
They might play a role as a major cellular component of the bone marrow niche for hematopoietic stem cells [ 1 ]. (biomedcentral.com)
IRF8 regulates development of myeloid lineage cells: It is expressed in a series of myeloid progenitors in bone marrow that are derived from hematopoietic stem cells. (nih.gov)
Currently, the most common way to retrieve these cells is through surgery to remove them from the person's bone marrow or fat. (nih.gov)
Much of the NIAMS investment in stem cells has focused on the biology and application of adult stem cells, including bone marrow derived mesenchymal stem cells (MSC), stem cells and satellite cells obtained from skeletal muscle, and keratinocyte and other multipotent stem cells obtained from skin. (nih.gov)

ASCs have been thought for a long time to be far less potent in terms of renewal and differentiation potential than ESCs. (medscape.com)
Reconstitution of lost cell types, as in patients with Parkinson's disease, might be accomplished, along these lines, simply with an autologous transplant (without any histoincompatibility issue) completely bypassing all the difficulties associated with the preparation and use of ESCs. (medscape.com)
Based on their origin, stem cells are categorized either as embryonic stem cells (ESCs) or as postnatal stem cells/somatic stem cells/adult stem cells (ASCs). (axonmedchem.com)
However, directed differentiation of human iPSCs (hiPSCs) or ESCs into folliculogenic EpSCs has not been successful to date and remains an important challenge that needs to be addressed. (nature.com)
1,2 Regarding the origin, they can be classified as embryonic stem cells (ESCs) and adult stem cells (ASCs). (bvsalud.org)
3 Embrionic stem cells (ESCs) are derived from the inner cell mass of the blastocyst and form all cell types, derived from the three germ layers, and are therefore pluripotent. (bvsalud.org)
To induce differentiation toward hematopoietic stem cells (HSCs) in vitro, ESCs were cultured in methylcellulose with stem cell factor, interleukin (IL)-3, and IL-6. (rupress.org)

Therefore, combining both aging research and appropriate interrogation of animal disease models towards the understanding of the disease and age-related stem cell failure is imperative to the discovery of new therapies. (frontiersin.org)
However, the cancer cell therapy space has become very crowded and drug developers are currently seeking to expand the field into autoimmunity, with biotech and pharmaceutical companies employing a variety of strategies to develop differentiated cellular therapies against autoimmune diseases that present a huge unmet need. (alacrita.com)
Newer, more targeted therapies aim to neutralize key proinflammatory cytokines, interfere with and inhibit the activation of lymphocytes, or enhance the pathways that suppress these cells. (alacrita.com)
Among the human diseases that could be treated by the stem cell-based therapies, there are hematopoietic and immune disorders, multiple degenerative disorders, such as Parkinson's and Alzheimer's diseases, type 1 or 2 diabetes mellitus as well as eye, liver, lung, skin and cardiovascular disorders and aggressive and metastatic cancers. (nih.gov)
Recent advances in cancer stem/progenitor cell research also offer the possibility to targeting these undifferentiated and malignant cells that provide critical functions in cancer initiation and progression and disease relapse for treating the patients diagnosed with the advanced and metastatic cancers which remain incurable in the clinics with the current therapies. (nih.gov)
Stem cells are an attractive option in developing cell-based therapies to improve tendon healing. (hindawi.com)
Stem cells sourced from the adult kidney have the potential benefits of improved renal engraftment and differentiation and can be utilized in autologous therapies. (biomedcentral.com)
Many in the international scientific community believe that the promise of stem cell-based studies or therapies will be realized only if we can derive new human embryonic stem cell (hESC) lines. (jci.org)
Therefore, focusing on cell-free therapies is of high importance [ 19 ]. (biomedcentral.com)
In most cases, clinically relevant cell numbers for MSC-based therapies can be only obtained by in vitro expansion of isolated cells. (frontiersin.org)
Patient-specific iPS cell lines have now been reported for several diseases, providing the tools for studies of disease pathogenesis, for screening of drugs, and for the combined gene and cell-based therapies for genetic defects. (nih.gov)
The NIAMS investment in human iPSCs is currently limited to a very small number of projects studying the reprogramming process, creating safer and more efficient ways to generate patient-specific iPSCs for gene and cell-based therapies, investigating disease pathogenesis and studying differentiation of stem cell progeny. (nih.gov)
Research and demonstrations of clinical efficacy are the only means for validating whether stem cell- mediated therapies will materialize. (nih.gov)

The presence of multipotent human limbal stromal cells resembling mesenchymal stromal cells (MSC) provides new insights to the characteristic of these cells and its therapeutic potential. (molvis.org)
We studied the expression of SSEA-4 surface protein and the various ESC and MSC markers in the ex vivo cultured limbal stromal cells. (molvis.org)
Limbal stromal cells were derived from corneoscleral rims. (molvis.org)
The SSEA-4 + and SSEA-4 - limbal stromal cells were sorted by fluorescence-activated cells sorting (FACS). (molvis.org)
Expanded limbal stromal cells expressed the majority of mesenchymal markers. (molvis.org)
The expanded limbal stromal cells showed features of multipotent MSC. (molvis.org)
Our study confirmed the expression of SSEA-4 by a subpopulation of cultured limbal stromal cells. (molvis.org)

Thus, the generation of ergodic expression fluctuations may be a generic way in which cell populations maintain robust multilineage differentiation potential under environmental uncertainty. (soton.ac.uk)

Pathway of mesenchymal stem cell differentiation into tenocytes. (hindawi.com)
And what is autologous mesenchymal stem cell therapy? (plexusnc.com)
Depending on the type of disease, mesenchymal stem cell therapy can help restore function of damaged cells, replace dead cells, and slow down the rate of further deterioration of cells. (plexusnc.com)

Recent reports of multipotent cells that are able to generate cells with neuronal properties have raised expectations that such cells might be used to replace lost neurons and glia, repair defective circuits, and restore functions compromised by age, physical damage or disease. (nih.gov)
Cell-fusion events, between an ESC and a blood cell or between an ESC and a neuronal precursor (with the formation of tetraploid precursors), have also misled some investigators. (medscape.com)
In animal studies, multipotent progenitor cells from many different sources have been reported to generate cells with neuronal or glial properties, raising expectations that they could be used to replace lost neurons and glia, repair defective circuits, and restore functions compromised by abnormal development, age, physical damage, disease or drug addiction. (nih.gov)
Studying the differentiation of hESCs on permissive substrates has also been a focus and is of importance because of the relevance to the developing and adult human brain, where a complex extracellular matrix exists as scaffolding for neuronal development. (5dok.org)
The regulatory programs governing this process remain incompletely characterized, however, in part because of the difficulty in studying neuronal progenitor cells in their native environments. (nih.gov)
Therefore, it is crucial to explore ways to improve the proliferation and neuronal differentiation of endogenous NSCs, and identify the underlying molecular mechanisms. (biomedcentral.com)
17. Neuronal differentiation of cryopreserved neural progenitor cells derived from mouse embryonic stem cells. (nih.gov)

Histologically, the tumors are heterogeneous with mesenchymal and neural crest characteristics as evidenced by expression of the neural crest markers p75, SOX-10, and S-100, with populations of tumor cells exhibiting characteristics of primitive neuroectodermal cells. (nih.gov)
Of high priority are studies to develop methods for identifying, isolating and characterizing specific precursor populations at intermediate stages of differentiation into neurons and glia, and their relationship to tumor- generating cells. (nih.gov)
Here,we describe a gene expression analysis of laser capture microdissection purified gastric cell populations that identified the bHLH transcription factor Mist1 as a potential ZC regulatory factor. (biologists.com)
There is a growing body of evidence to suggest that stem cell populations from both the embryo and the adult are heterogeneous in their gene expression patterns. (soton.ac.uk)
This thesis explores cell-to-cell variability in both multipotent and pluripotent stem cell populations using mathematical models to provide a theoretical framework to understand the collective dynamics of stem cell populations. (soton.ac.uk)
In the second part of this thesis we consider the dynamics of populations of multipotent adult hematopoietic stem cells (HSCs). (soton.ac.uk)
Organ complexity and low turnover of renal cells has made stem cell identification difficult and lead to the investigation of multiple possible populations. (biomedcentral.com)
The methods used to locate potential stem cell populations can vary widely, but even within the relatively standard practice of BrdU labeling of slowly dividing cells, there are significant differences in protocols and results. (biomedcentral.com)
But even without firmly defined populations, the application of renal stem cells holds tantalizing potential. (biomedcentral.com)
Populations of highly proliferative, multipotent cells of renal origin show the ability to engraft in injured kidneys, mitigate functional loss and occasionally show the ability to generate nephrons de novo . (biomedcentral.com)
In each case, potential renal stem cells populations are evaluated on criteria often used to define and characterize adult stem cell populations, namely self-renewal, colony forming ability, molecular marker profiles and multipotency [ 6 ]. (biomedcentral.com)
Flow cytometry was used to evaluate the immune cell populations, while cytokine/chemokine production was measured by real-time polymerase chain reaction and enzyme-linked immunosorbent assay. (biomedcentral.com)
The different types of stem cell populations can be illustrated by considering the earliest stages of embryogenesis (Figure 1 ). (jci.org)

Induced pluripotent stem cells (iPSCs) have been generated from somatic cells by transduction of reprogramming transcription factors, such as cMYC , SOX2 , KLF4 and OCT4 . (nature.com)
Reprogramming of somatic cells into iPSCs has tremendous potential for clinical application. (nature.com)
However, there remain challenges in differentiating iPSCs into certain cell types. (nature.com)
iPSCs are not adult stem cells in origin but mature adult cells that are modified resulting in cell pluripotency and the characteristics of embryonic cells [ 4 , 5 ]. (hindawi.com)
Induced pluripotent stem cells (iPSCs) also exhibit pluripotency but they are artificially generated from adult cells, which bypasses ethical concerns associated with embryonic stem cells. (uclmed.tech)
However, the creation of iPSCs is still a very inefficient process, and considerable international effort is underway to find more efficient and safer ways to generate these cells. (nih.gov)

The process of a cell becoming specialized is called differentiation. (brighthub.com)

Human iPSC-derived CD200 + /ITGA6 + cells are capable of generating all hair follicle lineages including the hair shaft, and the inner and outer root sheaths in skin reconstitution assays. (nature.com)
Negative stem cell markers indicate other cell lineages such as hematopoietic and endothelial cells and include CD 14, 31, 34, and 45 [ 14 - 17 ]. (hindawi.com)
The generation of cellular diversity in the nervous system requires the specification and differentiation of a multitude of cell lineages from multipotent progenitor cells. (nih.gov)
These cells can be differentiated into various cell lineages and considering their rapid proliferation, multipotency and immunomodulatory properties they are widely used for treatment of various diseases. (ijbiotech.com)

For this to occur, the stem or progenitor cell should respond to proliferative and/or guidance cues that are either induced by the injury or degeneration, or supplied exogenously, but subsequently turn off these programs once normal cell numbers and circuitry have been attained. (nih.gov)
The adult central nervous system (CNS) contains resident stem cells within specific niches that maintain a self-renewal and proliferative capacity to generate new neurons, astrocytes, and oligodendrocytes throughout adulthood. (frontiersin.org)
Specific properties, such as proliferative and differentiation potential, are slightly different among DSCs. (bvsalud.org)
Our molecular and ultrastructural analysis of proliferation, migration and differentiation of the gastric unit in Mist1 -/- and control mice supports a model whereby wild-type ZC progenitors arise as neck cells in the proliferative (isthmal) zone of the gastric unit and become transitional cells(TCs) with molecular and ultrastructural characteristics of both enzyme-secreting ZCs and mucus-secreting neck cells as they migrate to the neck-base zone interface. (biologists.com)
This cell contains a different set of genetic instructions (resulting in an alternative pattern of gene expression) and is characterized by a reduced proliferative capacity and more restricted developmental potential than its parent. (jci.org)
Mixed lymphocyte culture assays demonstrated T cell tolerance to both recipient and donor but intact third party proliferative responses and interferon γ production. (rupress.org)

RESEARCH OBJECTIVES Background One of the most exciting frontiers in medicine is the potential use of stem cells for treating congenital or degenerative disorders. (nih.gov)
The cells also have potential medical applications, especially in organ regeneration. (wikipedia.org)
At around the same time, it was determined that stem cells from the amniotic membrane also have multipotent potential. (wikipedia.org)
There is some debate whether c-Kit is a suitable marker to distinguish amniotic stem cells from other cell types because cells lacking c-Kit also display differentiation potential. (wikipedia.org)
Furthermore, in an age where cloning has become an everyday reality, any living cell holds within it the potential of becoming a fully formed life. (wheelchairkamikaze.com)
Most serious research scientists, though, say that embryonic stem cells hold by far the greater potential to do good. (wheelchairkamikaze.com)
RESEARCH OBJECTIVES Background Stem cell research offers enormous potential for treating a host of congenital, developmental, psychiatric or degenerative diseases for which there are no cures. (nih.gov)
Additional diversity exists in cell marker profiles and apparent differentiation potential seen in potential stem cell sources. (biomedcentral.com)
Because of this, we will discuss potential stem cell sources based on anatomical origin, namely from the Bowman's capsule, the renal papilla and the nephron tubules. (biomedcentral.com)
Early embryos contain totipotent stem cells, which have the remarkable potential to develop into any type of cell. (uclmed.tech)
Based on their potency and potential for self-renewal, stem cells can be used to treat a number of diseases. (electronichealthreporter.com)
Now, you have been given a broader view of stem cells and their potential, let us dive into the meat of the matter. (electronichealthreporter.com)
Embryonic stem cells, which can be obtained at a very early stage of human development, have the potential to produce all types of cells of the human body. (orthopedia.gr)
Stem cell research has emerged as a groundbreaking field with immense potential to revolutionize medicine, offering hope for treating a wide array of diseases and injuries. (falconediting.com)
This article delves into the world of stem cell research, exploring its potential, controversies, and the delicate balance between scientific advancement and ethical considerations. (falconediting.com)
By generating insulin-producing cells from stem cells, scientists aim to offer a potential cure for diabetes or more effective management options, reducing the burden on patients and healthcare systems. (falconediting.com)
Furthermore, stem cells have the potential to address a wide range of conditions, from degenerative eye diseases like macular degeneration to autoimmune disorders like multiple sclerosis. (falconediting.com)
Stem cells are a diverse group of cells with varying properties and capabilities, each offering unique potential and ethical considerations. (falconediting.com)
Each potential use of stem cells promises revolutionary advances. (jci.org)
The phenotypes and multipotent differentiation potential of these cells were also evaluated. (molvis.org)
18. Derivation and characterization of canine embryonic stem cell lines with in vitro and in vivo differentiation potential. (nih.gov)
Stem cells from different sources with different potential (plasticity) may be used to obtain ideal cell lineage with a defined function. (ijbiotech.com)
What is the Therapeutic Potential of Mesenchymal Stem Cells for Diabetes? (alphacelle.com)

Montserrat N, Jopling C, Izpisua Belmonte JC (2010) Understanding the molecular basis for cardiomyocyte cell cycle regulation: new insights in cardiac regeneration after injury? (springer.com)
Beltrami AP, Barlucchi L, Torella D et al (2003) Adult cardiac stem cells are multipotent and support myocardial regeneration. (springer.com)
Continuous regeneration of digestive enzyme (zymogen)-secreting chief cells is a normal aspect of stomach function that is disrupted in precancerous lesions (e.g. metaplasias, chronic atrophy). (biologists.com)
The field has aquired a good general base of knowledge, but scrutiny of the techniques and outcomes will be necessary to move toward a unified explanation of renal regeneration and the role of organ-specific stem cells in the kidney. (biomedcentral.com)
As a complementary approach, we also apply single-cell transcriptomic and single-cell epigenomic analyses to identify the genetic and epigenetic programs that both define and regulate olfactory neurogenesis during regeneration. (nih.gov)
They have the capacity to undergo dynamic endocrine-induced changes during the menstrual cycle, including cell growth and regeneration, in order to provide the unique environment required for the maintenance of male and female gamete viability, fertilization, and early embryo development as well as transport to the uterus [ 24 ]. (biomedcentral.com)
In mature mammalian cochleae, virtually no mechanosensitive hair cell regeneration is detectable. (genesispub.org)

They are also referred to as somatic stem cells -- "the term "somatic" refers to non-reproductive cells in the body (eggs or sperm). (kinesiologyshop.com)

When called into action following an injury, a stem cell self-renews - undergoes cell division and gives rise to one daughter stem cell and one progenitor cell. (axonmedchem.com)
A progenitor cell is an intermediate cell type formed before it achieves a fully differentiated state. (axonmedchem.com)
Donor Evaluation for Hematopoietic Stem and Progenitor Cell Collection -- 5. (nshealth.ca)
Concepts and Rationale for Using Predictive Algorithms for Hematopoietic Progenitor Cell Apheresis Collection -- 10. (nshealth.ca)

Epithelial stem cells (EpSCs) in the hair follicle bulge are required for hair follicle growth and cycling. (nature.com)
In the skin, epithelial stem cells (EpSCs) in the hair follicle contribute not only to the generation of a new hair follicle with each hair cycle but also to the repair of the epidermis during wound healing 3 , 4 . (nature.com)

The cell therapy field has been predominantly active in the oncology space and is enjoying bench-to-bedside clinical success. (alacrita.com)
The burgeoning preclinical and clinical experience with human adult adipose-derived cells appears to be promising but interpretation of the current literature with in vitro studies, translational research and FDA-registered investigations emphasizes the need for standardized methods to advance basic science knowledge and beneficial safe clinical outcomes. (scirp.org)
Since the specialty of Plastic Surgery with its position statement on stem cells and fat grafting is committed to advancing evidence-base preclinical and clinical studies in compliance with FDA-regulations, an updated review of cell biology provides insights to achieve these goals. (scirp.org)
This multidisciplinary book provides up-to-date information on clinical approaches that combine stem or progenitor cells, biomaterials and scaffolds, growth factors, and other bioactive agents in order to offer improved treatment of urologic disorders including lower urinary tract dysfunction, urinary incontinence, neurogenic bladder, and erectile dysfunction. (nshealth.ca)
The purpose of this paper is to outline the current research on developing a clinical stem cell therapy for the augmentation of tendon healing. (hindawi.com)
Stem cell treatments and clinical trials have been going on for over 40 years, however we are still in the early stages of stem cell therapy being utilized as an effective alternative treatment method to traditional pharmaceutical based treatments. (stemcellthailand.org)
Much of the early work in stem cell clinical trials focused on the overall effectiveness and safety of the procedures involved. (stemcellthailand.org)
Here are some resources for clinical trials using stem cells around the world. (stemcellthailand.org)
Australian Clinical Trials - Therapy for Peripheral Vascular Disease - Double blind, randomized safety and feasibility evaluation of intra-arterial CD34+ cell delivery for severe peripheral arterial disease - This trial in Australia aims to compare the effect of the patient's own peripheral blood stem in treating patients with severe peripheral arterial disease. (stemcellthailand.org)
Research into renal stem cells may help elucidate mechanisms of renal homeostasis and healing, but the ultimate goal is to utilize those stem cells for clinical treatments. (biomedcentral.com)
In essentially all the clinical trials, and in most experiments in animal models, the cells were administered by intravenous (IV) injection. (biomedcentral.com)
In recent years, there have been many clinical trials investigating the use of stem cells, one of the latest publications describes a Phase I trial using allogenic stem cell-based therapy in people with progressive multiple sclerosis this year which marks an important milestone in the search for a suitable therapy (Fossati, Peruzzobtti-Jametti and Pluchino, 2023). (uclmed.tech)
2017 produced a review that describes 11 clinical trials with a total of 647 patients and claimed these stem cells significantly improved heart function and reduced incidence of major adverse cardiovascular events. (uclmed.tech)
Laboratory and clinical studies have proven that mature stem cells can be used in a number of degenerative diseases. (orthopedia.gr)
From 2 wk to 6 mo after injection, the peripheral blood demonstrated increasing ESC-derived mononuclear cells that included donor-derived T and B lymphocytes, monocytes, and granulocytes without clinical or histologic evidence of graft-versus-host disease (GVHD). (rupress.org)
However, despite the utility of experimental animals, limitations in the accuracy of animal testing and associated ethical issues have given rise to the development of non-clinical tests using human cell sources. (j-organoid.org)
The accomplishments have sparked renewed interest in exploring cell therapy clinical trials for the dystrophies. (nih.gov)

Hematopoietic stem cells (HSCs), for example, undergo senescence with telomere shortening. (medscape.com)
Second, stem cells can, on cue, undergo an asymmetric division to produce two dissimilar daughter cells. (jci.org)
Mitotic cells might undergo senescence by failing to replicate. (hindawi.com)

The alveolar cells fuse to endothelial cells by their basal membranes to form the gas exchange barrier. (stemcell.com)
Vodyanik MA, Yu J, Zhang X et al (2010) A mesoderm-derived precursor for mesenchymal stem and endothelial cells. (springer.com)
It consists primarily of three layers: an outer layer of epithelium, a middle stromal layer of collagen-rich extracellular matrix (ECM) interspersed with keratocytes and an inner layer of endothelial cells. (molvis.org)

The stem cells are usually extracted from the amniotic sac by amniocentesis which occurs without harming the embryos. (wikipedia.org)
The use of amniotic fluid stem cells is therefore generally considered to lack the ethical problems associated with the use of cells from embryos. (wikipedia.org)
But the embryos in question here are zygotes, clumps of at most a few dozen cells. (wheelchairkamikaze.com)
These stem cells are derived from embryos, typically during the blastocyst stage, which occurs within the first few days after fertilization. (falconediting.com)
At the present time, the production of new cell lines involves destruction of preimplantation embryos at the 100-200 cell (blastocyst) stage. (jci.org)
3. Derivation of embryonic stem cell line from frozen human embryos and neural differentiation. (nih.gov)
12. Human embryonic germ cells isolation from early stages of post-implantation embryos. (nih.gov)
Embryos which are a few days old, known as blastocysts, are used to make ES cells in the lab. (ed.ac.uk)
iPS cells are also seen as a more ethically acceptable type of stem cell than embryonic stem cells, as no embryos are destroyed in the production of iPS cells. (ed.ac.uk)

Dysregulation of miRNA has been demonstrated to be linked with many diseases via regulating various biological functions such as cell differentiation, proliferation, apoptosis, migration and metastasis, providing a perspective on achieving safe and targeted delivery of miRNA therapeutics [ 7 ]. (biomedcentral.com)
We also investigated how cytotoxic T cells activate programmed cell death (apoptosis) in virally infected cells. (the-scientist.com)

Stem cells are unspecialized cells with an extraordinary ability to self-renew, capable of differentiating into one or more specialized cell types. (axonmedchem.com)
Stem cells can also self-renew, which means that they can replace themselves so that your supply of stem cells doesn't run out. (ed.ac.uk)

However, the role of caveolin-1 in human MSC osteogenic differentiation remains unexplored. (nih.gov)

The cell biology of adipocytes has led to a number of promising concepts in the last century, especially in the areas of obesity and associated diseases, lipid homeostasis and endocrine functions. (scirp.org)

However, it remains unclear whether the cells originate from the fetus itself, the placenta or possibly the inner cell mass of the blastocyst. (wikipedia.org)
In vitro differentiation of human placenta-derived multipotent cells into hepatocyte-like cells. (stemcellthailand.org)
3,4 The zygote and cells derived from the first two cellular divisions constitute the most primitive cells (totipotent cells) that are capable of forming the embryo and the embryonic annexes (e.g. placenta, amniotic membranes etc). (bvsalud.org)
the trophectoderm, shown in red in this image, which surrounds the blastocyst and goes on to form the placenta, and the inner cell mass, shown in green, which is found inside the blastocyst. (ed.ac.uk)
Placental stem cells: The placenta has become useful source of stem cells that offer advantages in terms of proliferation and plasticity when compared with adult cells (3). (ijbiotech.com)
The epithelia, haematopoietic and mesenchymal stem cells are major stem cells isolated from the placenta. (ijbiotech.com)
The first type of stem cell is totipotent, which derive from the zygote and are able to form the embryo and trophoblasts of the placenta. (genesispub.org)

Within the latter compartment, a subset of cells with multipotent differentiation capacity exists, usually referred to as mesenchymal stem cells. (kinesiologyshop.com)

The pluripotency of these embryonic-like stem cells remains to be fully established. (wikipedia.org)
Unlike specialized cells, which have limited functions, stem cells possess pluripotency or multipotency, meaning they can become a wide array of cell types. (falconediting.com)
Pluripotency distinguishes ES cells from adult stem cells which are multipotent cells with the capacity to produce limited number of cell types (2). (ijbiotech.com)

11. Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst. (nih.gov)

The tremendous plasticity exhibited by stem and progenitor cells raises the possibility that they can be used to replace components and restore function to parts of the brain that have been compromised by congenital disorders, developmental malfunction, injury or disease. (nih.gov)
CHARACTERIZATION, BEHAVIOR AND PLASTICITY OF PLURIPOTENT STEM CELLS RELEASE DATE: May 4, 2004 PA NUMBER: PA-04-101 The R01 portion of this funding opportunity has been replaced by PA-07-201 , which now uses the electronic SF424 (R&R) application for February 5, 2007 submission dates and beyond. (nih.gov)

Human embryonic stem cells (hESCs) and hESC-derived neural progenitors (NPs) may provide a number of new ways for studying and treating diseases and injuries in the brain. (5dok.org)
Second, extramedullary stem cells/multipotent progenitors (HSC/MPPs) from spleen, PB and mPB share a common transcriptional signature and increased abundance of lineage-primed subsets compared to BM. (kumamoto-u.ac.jp)

Importantly, there is a pressing need for therapeutic drugs that specifically target pathogenic cells whilst leaving the remainder of the immune system functioning normally. (alacrita.com)
The Transendocardial Autologous Cells (hMSC or hBMC) in Ischemic Heart Failure Trial (TAC-HFT) - The technique of transplanting progenitor cells into a region of damaged myocardium, termed cellular cardiomyoplasty, is a potentially new therapeutic modality designed to replace or repair necrotic, scarred, or dysfunctional myocardium. (stemcellthailand.org)
In fact, some adult stem cells are used for therapeutic purposes today. (orthopedia.gr)
Regardless of the differences in differentiation capacity of embryonic and adult stem cells, both the cells are rich sources of stem cells with therapeutic application. (ijbiotech.com)
These natural nanoparticles have therapeutic effects in various diseases and exhibit a behavior similar to the cell from which they originated. (biomedcentral.com)
At present, significant advances have been made in stem cell technology with good therapeutic prospects for treating different diseases such as respiratory diseases [ 12 ]. (biomedcentral.com)
Stem cells for therapeutic use can be categorized as embryonic stem cells (ESC), adult (and fetal or neonatal)-derived stem cells (ASC), or induced pluripotent stem cells (iPSC). (nih.gov)
But in contrast to Senator Brownback's proposed legislation, your bill takes a more enlightened position in permitting the somatic cell nuclear transplant procedure for research and therapeutic purposes. (nih.gov)

Here, we identify adult stem cell deficits that drive ENT3-related abnormalities in mice. (nature.com)
Genetic, pharmacologic and stem cell interventions ameliorate ENT3-disease pathologies and extend the lifespan of ENT3-deficient mice. (nature.com)
identified a tendon progenitor stem cell (TPSC) population in both mice and humans [ 14 ]. (hindawi.com)
Our previous work demonstrated a positive correlation between life span and the number of very small embryonic-like stem cells (VSELs) in long living Laron dwarf mice. (biomedcentral.com)

Mobilization Strategies: HPC(A) Collections for Autologous Hematopoietic Cell Transplants -- 6. (nshealth.ca)
At Plexus, we use autologous mesenchymal stem cells to treat a plethora of neurological disorders. (plexusnc.com)
Autologous Adult Stem cells have been used to treat many chronic degenerative diseases of the musculoskeletal system, such as osteoarthritis, tendonitis and tendon rupture. (orthopedia.gr)

An understanding of environmental cues, age-dependent processes and genetic factors that govern the activities of these cells is crucial in order to develop safe and effective cell-replacement treatments. (nih.gov)
An understanding of intrinsic and extrinsic signals, especially those involved in the stem cell niche, age-dependent processes and genetic factors that govern the activities of pluripotent cells is crucial in order to utilize them to develop safe and effective treatments for the restoration of function, or to prevent their transformation into tumor-generating cells. (nih.gov)
The cellular and genetic pathways that underlie zymogenic cell (ZC) differentiation are poorly understood. (biologists.com)
The functions aren't limited to that, because advances in stem cell research are developing ways to correct a lot of genetic and mutational abnormalities. (electronichealthreporter.com)
Usually the daughter cells are identical to the parent cell, but in the case of a stem cell undergoing differentiation, the daughter cells are more specialized than their parent cell because of genetic signals. (brighthub.com)
It also means that cells which are a close genetic match to the patient can be selected. (ed.ac.uk)
High-throughput genetic screening approaches are broadly applied in model organisms and cells to delineate cellular pathways and identify components of cellular networks. (biomedcentral.com)
Activation of the cellular senescence genetic program prompts a series of molecular changes, mostly affecting cell cycle, extracellular matrix (ECM), secretion of growth factors, and inflammatory mediators. (hindawi.com)
The G/M phases of the cell cycle comprise a series of regulatory biochemical steps and coordinated cellular events that ensure the faithful partitioning of genetic and cytoplasmic components. (nih.gov)

Specifically, the type of stem cell, the amount of cells, and the proper combination of growth factors or mechanical stimuli to induce differentiation all remain to be seen. (hindawi.com)

15. Derivation of three clones from human embryonic stem cell lines by FACS sorting and their characterization. (nih.gov)

Here we comprehensively delineate human extramedullary HSPC compartments comparing spleen, PB and mobilized PB (mPB) to BM using single-cell RNA-seq and/or functional assays. (kumamoto-u.ac.jp)

Following on recent advances in understanding single cell behavior (Carrera & Covert, Trends in Cell Biology, 2015), and in developing simple, proof-of-concept biological machines (Raman et al. (selectbiosciences.com)
To engage in this debate, it is important to have an overview of stem cell biology. (jci.org)
As part of my medical training in hematology and oncology, I began a postdoc at MIT in the lab of Herman Eisen in the early eighties when molecular biology was just coming into its own: The T-cell receptor had just been discovered (work to which the Eisen lab contributed), and HIV was about to be identified as the cause of AIDS. (the-scientist.com)
There have been rapid advances in the biology and understanding of stem cells in the last three years. (nih.gov)
am also Chairman of the American Society of Cell Biology Public Policy Committee. (nih.gov)

The higher numbers of BM-residing VSELs in these animals also correlated with higher numbers of hematopoietic stem progenitor cells (HSPCs) in BM. (biomedcentral.com)

Quite simply, stem cell therapy offers my best, and, quite possibly, last hope at beating back this fracking disease. (wheelchairkamikaze.com)
The ability to obtain stem cells for cell-based therapy (CBT) is limited due to donor site morbidity and the invasive nature of the harvesting process. (wjgnet.com)
Stem cell therapy - Hype or hope? (axonmedchem.com)
Stem cell therapy has become the go-to method for managing the symptoms and delaying the progression of several medical conditions. (plexusnc.com)
In medical science, few advancements have held as much more promise as stem cell therapy. (uclmed.tech)
In Parkinson's disease (PD), there have been significant advancements in therapy by using dopaminergic neurones derived from stem cells to restore motor functions in animal models. (uclmed.tech)
Stem cell therapy can be described as the use of stem cells to treat, prevent and mollify the effects of a particular disease condition. (electronichealthreporter.com)
Current stem cell research and stem cell news are providing outlets for growing stem cell therapy rapidly. (electronichealthreporter.com)
Compared to a heavily invasive procedure like surgery, people who opt for stem cell therapy will experience less pain, recover faster, and have a greater quality of life overall. (electronichealthreporter.com)
More groundbreaking research is being done on stem cell therapy and more advantages are forthcoming. (electronichealthreporter.com)
Even though there is a great public interest in the use of stem cells among stem cell scientists including the International Society For Stem Cell Research , one of the largest academic organizations of scientists and advocates for stem cell research in the world, stem cell therapy is still under development. (electronichealthreporter.com)
In order to determine whether or not the patient is a suitable candidate for stem cell therapy, the physician must obtain a detailed history of the injury and then perform a detailed physical examination, x-rays and possibly recommend magnetic resonance imaging. (orthopedia.gr)
Stem cell therapy is not indicated for all musculoskeletal disorders, but for a limited number and under appropriate conditions. (orthopedia.gr)
Each patient is different, and the success of stem cell therapy depends on the severity of the disease and the body's response to the treatment itself. (orthopedia.gr)
Stem cell therapy aims to replace these damaged neurons with healthy, functional ones, potentially restoring motor function and improving patients' quality of life. (falconediting.com)
I decided that my new lab would work on understanding the T-cell response to HIV and why these cells fail to control the infection, with an eye towards developing immune-based therapy. (the-scientist.com)

This review article will highlight the main intrinsic and extrinsic regulators of neural stem cell (NSC) aging and discuss how these factors impact normal homeostatic functions within the adult brain. (frontiersin.org)

This Monday, President Obama will lift the nearly 8-year-old ban on federal funding for embryonic stem cell research. (wheelchairkamikaze.com)
I realize many people are morally opposed to embryonic stem cell research because they believe the destruction of a human embryo is tantamount to the taking of a human life. (wheelchairkamikaze.com)
The ruling banned such research being done at any facility that received federal funding for any purposes whatsoever, and virtually no facility sophisticated enough to conduct responsible embryonic stem cell research was completely free of products, equipment, or personnel that hadn't been procured with federal funds. (wheelchairkamikaze.com)
This has led to an intense debate that threatens to limit embryonic stem cell research. (jci.org)

In 2009, the first US amniotic stem cell bank was opened in Medford, MA, by Biocell Center, an international company specializing in the cryopreservation and private banking of amniotic fluid stem cells. (wikipedia.org)

Lastly, unipotent stem cells only give rise to one specific cell type but have the power to renew which distinguishes them from non-stem cells. (uclmed.tech)

The presence of embryonic and foetal cells from all germ layers in the amniotic fluid was gradually determined since the 1980s. (wikipedia.org)
ES cells are readily differentiated into primary germ layers, viz. (ijbiotech.com)

This Program Announcement encourages applications for support of ground-breaking research on non-human stem cells that address these issues. (nih.gov)
ENT3 is unique as the only intracellular nucleoside transporter in the family with putative localization in late endosomes, lysosomes, and mitochondria (other human ENTs (hENTs) primarily function at the cell surface) 19 , 20 . (nature.com)
But I also hold the highest regard for human life and believe that a human embyro (some call it just a cluster of cells) is sacred and believe the intentional destruction of human life is wrong. (wheelchairkamikaze.com)
Projects that address comparisons between different classes of human stem cells and between human and non-human stem cells would also be directly relevant to this PA. (nih.gov)
Recent progress in the field of the stem cell research has given new hopes to treat and even cure diverse degenerative disorders and incurable diseases in human. (nih.gov)
The hiPSC-derived CD200 + /ITGA6 + cells show a similar gene expression signature as EpSCs directly isolated from human hair follicles. (nature.com)
hiPSC clones exhibiting characteristic human embryonic stem cell (hESC) morphology were isolated ~45 days after transduction ( Supplementary Fig. 1a ). (nature.com)
the only long distance cell migration system in the human brain) and that of hESC-derived NPs. (5dok.org)
Finally, we studied the adult human brain for the presence of progenitor cells with migratory characteristics. (5dok.org)
Further, we discovered a number of differentiation factors expressed (Pax6, NCAM, DCX, βIII-tubulin) in common between the human RMS neuroblasts and hESC-derived NPs. (5dok.org)
Neural stem cells (NSCs) are present in the human adult brain. (kinesiologyshop.com)
The limbus of the eye, located at the junction of the cornea and conjunctiva of the ocular surface, represents a unique stem cell niche in human body. (molvis.org)
2. Expansion of pluripotent human embryonic stem cells on human feeders. (nih.gov)
4. Comparative characteristics of three human embryonic stem cell lines. (nih.gov)
7. Basic fibroblast growth factor supports undifferentiated human embryonic stem cell growth without conditioned medium. (nih.gov)
8. Autogeneic feeders for the culture of undifferentiated human embryonic stem cells in feeder and feeder-free conditions. (nih.gov)
9. Establishment of a human embryonic germ cell line and comparison with mouse and human embryonic stem cells. (nih.gov)
13. Derivation of human embryonic stem cell lines in serum replacement medium using postnatal human fibroblasts as feeder cells. (nih.gov)
Network analysis showed a kinome fingerprint that differs from human primary fibroblasts as well as fibroblast cell lines. (biomedcentral.com)
Mesenchymal Progenitor Cells Derived from Traumatized Human Muscle. (nih.gov)
For example, keratinocyte stem cells can be expanded in culture and used to create human skin equivalents to treat burn patients. (nih.gov)
Similar regulation occurs in human cells, where down-regulation of Wee1 by Plk1 is critical for entry into mitosis. (nih.gov)

Totipotent cells, found only in the embryo within a few days of fertilization, can become any kind of cell in the body. (brighthub.com)

Anatomy70

Organisms15

Diseases7

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes55

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science3

MSCs52

Differentiate36

Tissues44

Tissue51

Proliferation and differentiation7

Adipogenic5

Regenerative15

Transplantation12

Bone15

ESCs7

Therapies13

Stromal cells7

Multilineage differentiation1

Mesenchymal stem3

Neuronal7

Populations13

IPSCs6

Specialized is called differentiation1

Lineages4

Proliferative6

Potential23

Regeneration7

Somatic stem cells1

Progenitor cell4

Epithelial stem cells2

Clinical17

Undergo3

Endothelial3

Embryos9

Apoptosis2

Self-renew2

Osteogenic differentiation1

Adipocytes1

Placenta7

Referred to as mesenchymal1

Pluripotency3

Vitro differentiation1

Plasticity2

Progenitors2

Therapeutic8

Mice4

Autologous3

Genetic9

Induce differentiation1

Characterization1

Assays1

Biology5

Hematopoietic Stem1

Therapy16

Neural stem1

Embryonic stem cel4

Amniotic fluid stem cells1

Unipotent stem1

Germ layers2

Human22

Totipotent1