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  • ligands
  • We investigated the ability of MRGPRX2 ligands to induce degranulation in rat basophilic leukemia-2H3 cells individually expressing these naturally occurring MRGPRX2 missense variants. (jimmunol.org)
  • Therefore, these findings, which may be relevant to clinical bone marrow transplantation, suggest that neither exposure to MHC class I ligands during NK development in the BM nor endogenous MHC class I expression by NK cells themselves is absolutely required for licensing. (rupress.org)
  • inhibit
  • Interestingly, our TCRP results showed that a Stat3 inhibitor JSI124 did not inhibit degranulation like other Stat3 inhibitors, such as Stattic, clearly inhibited degranulation. (sigmaaldrich.com)
  • Overexpression of cystathionine-γ-lyase increased endogenous H(2)S production and suppressed isoproterenol-induced renin release, suggesting that endogenous H(2)S may also inhibit renin release from As4.1 cells. (biomedsearch.com)
  • Asthma
  • In mouse models of allergic airway inflammation, the increase in lung mast cells in asthma can be mimicked and is mainly caused by the recruitment of mast cell progenitors to the lung. (diva-portal.org)
  • inhibitory
  • Functional reconstitution assays revealed that the inhibitory effect of Coro1a on MC degranulation strictly correlates with cortical localization of Coro1a, requires its filamentous actin-binding activity, and is regulated by phosphorylation of Ser2 of Coro1a. (rupress.org)
  • Recent nutraceutical formulations containing the natural anti-inflammatory and mast cell inhibitory flavonoid quercetin hold promise since they can be used together with other treatment modalities. (mastcelldisease.com)
  • Hence, NK cells use inhibitory receptors to assess the surface of self-tissues for MHC class I expression, providing a line of defense against pathogens and abnormal cell growth. (rupress.org)
  • Thus, self-MHC class I engagement by NK cell inhibitory receptors appears to be a fundamental element in acquisition of NK cell effector function. (rupress.org)
  • Conclusions
  • Conclusions Our study provides evidence of a self‐reactive, antigen‐specific CD 8+ T‐cell population in apoE −/− mice. (ahajournals.org)
  • membrane
  • Our results demonstrate a nonredundant function for the p101 and p84 PI3Kγ adaptor proteins and show that distinct pools of PtdIns(3,4,5)P 3 at the plasma membrane can elicit specific cell responses. (sciencemag.org)
  • It is known that mast cell degranulation depends upon membrane anchored SNAREs (soluble N-ethylmaleidimide-sensitive factor attachment protein receptors) and accessory proteins that form the trans-SNARE complex, a 4 helical bundle central to exocytic fusion. (usm.edu)
  • To investigate the properties of the degranulation related trans-SNARE complex, we decided to create a C-terminal truncation mutant of SNAP-23, which would arrest membrane fusion after the formation of the 4-helical bundle. (usm.edu)
  • neuronal cells
  • Therefore, this study was conducted to investigate the effect of CPT-11 on the enteric glial and neuronal cells, as well as to study the role of mast cells in the CPT-11-induced intestinal mucositis. (nih.gov)
  • indirect
  • Unlike conventional chemotherapies and targeted anticancer agents, which act directly on malignant cells or proximal stromal cells, immunotherapies have an indirect mechanism of action ( 7 ). (frontiersin.org)
  • role
  • However, its role in mast cell degranulation, which leads to hypersensitivity reactions in response to environmental factors, is not fully understood. (frontiersin.org)
  • Mast cells play an essential role in initiating allergic diseases. (sigmaaldrich.com)
  • It has not been explored whether CPT-11 is able to alter the enteric glial and neuronal cell, and the role of mast cells in this effect. (nih.gov)
  • Therefore, MCs might act as early sensors of amyloid peptide and recruit other cells to the neuroinflammatory response, thus playing a critical role in the onset and progression of AD. (jneurosci.org)
  • Our findings suggest that H(2)S plays a critical role in regulation of renin degranulation in As4.1 and rat renin-rich kidney cells. (biomedsearch.com)
  • Background T cells are found in atherosclerotic plaques, with evidence supporting a potential role for CD 8+ T cells in atherogenesis. (ahajournals.org)
  • extracellular
  • It was found that isoproterenol elevated intracellular cAMP level and extracellular renin activity but decreased renin protein level in the renin-rich kidney cells. (biomedsearch.com)
  • murine
  • Here, using a murine model of influenza A virus infection, this type of virus was demonstrated to trigger an extensive recruitment of mast cell progenitors to the lung, most likely through the induction of VCAM-1 expression in the lung endothelium. (diva-portal.org)
  • responses
  • While T cell- and Antibody (Ab)-mediated rejection mechanisms have been known for long as the prime actors ( 3 ), new evidences show that tissue inflammatory responses as well as the immunological environment including NK cells, dendritic cells, monocytes/macrophages, neutrophils, and eosinophils can importantly impact allograft acceptance and/or destabilize an established tolerant state ( 4 - 7 ). (frontiersin.org)
  • 4 , 11 , 12 , 13 , 14 , 15 These studies used various immunization techniques with the intent of inducing CD4+ T‐cell responses and antibody production. (ahajournals.org)
  • Antibody
  • CRC-NK cells also exhibited altered antibody-dependent cellular cytotoxicity function responding poorly to cetuximab. (frontiersin.org)
  • basophilic
  • Using stable and transient transfections, we found that all variants express in rat basophilic leukemia cells. (jimmunol.org)
  • Smears and conjunctival scrapings should be examined microscopically and stained with Gram stain to identify bacteria and stained with Giemsa stain to identify the characteristic epithelial cell basophilic cytoplasmic inclusion bodies of chlamydial conjunctivitis. (merckmanuals.com)